BGC0000529: microbisporicin A2 biosynthetic gene cluster from Microbispora corallina
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Location: 1,656 - 23,062 nt. (total: 21,407 nt).
This entry is originally from NCBI GenBank HM536998.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000529
Short description microbisporicin A2 biosynthetic gene cluster from Microbispora corallina
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
HM536998.1
1656 - 23062
via Knock-out studies, Heterologous expression
Compounds
  • microbisporicin A2
Species Microbispora corallina [taxonomy]
References
Chemical products information
microbisporicin A2 [synonyms: microbisporicin, NAI-107 A2] Evidence:
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C94H127Cl1N26O26S5
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADK32546.1
  • mibJ
 1656 - 2294 (+) MibJ, hypothetical membrane protein
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    • ADK32547.1
    • mibY
    		 2291 - 3067 (+) putative ABC permease
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      • ADK32548.1
      • mibZ
      		 3064 - 3966 (+) putative ABC transporter ATP-binding protein
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        • ADK32549.1
        • mibO
        		 3963 - 5207 (+) cytochrome P450
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          • ADK32550.1
          • mibQ
          		 5240 - 5629 (+) putative lipoprotein signal peptide-containing protein
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            • ADK32551.1
            • mibR
            		 5938 - 6720 (+) putative DNA-binding protein, transcriptional activator
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              • ADK32552.1
              • mibW
              		 7066 - 7833 (-) putative anti-sigma factor
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                • ADK32553.1
                • mibX
                		 7823 - 8485 (-) RNA polymerase, sigma-24 subunit, ECF subfamily
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                  • ADK32554.1
                  • mibA
                  		 8616 - 8789 (+) microbisporicin structural preproprotein
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                    • ADK32555.1
                    • mibB
                    		 8907 - 12254 (+) lantibiotic dehydratase
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                      • ADK32556.1
                      • mibC
                      		 12251 - 13708 (+) lantibiotic cyclase
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                        • ADK32557.1
                        • mibD
                        		 13737 - 14420 (+) flavoprotein decarboxylase
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                          • ADK32558.1
                          • mibT
                          		 14417 - 15367 (+) ABC transporter ATP-binding domain
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                            • ADK32559.1
                            • mibU
                            		 15345 - 16217 (+) ABC-type multidrug transport system permease component
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                              • ADK32560.1
                              • mibV
                              		 16225 - 17229 (+) hypothetical protein
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                                • ADK32561.1
                                • mibE
                                		 18028 - 18777 (+) putative lantibiotic ABC transporter permease protein
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                                  • ADK32562.1
                                  • mibF
                                  		 18779 - 19489 (+) putative lantibiotic ABC transporter ATP-binding protein
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                                    • ADK32563.1
                                    • mibH
                                    		 19522 - 21228 (+) tryptophan-5-halogenase
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                                      • ADK32564.1
                                      • mibS
                                      		 21225 - 21761 (+) flavin reductase
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                                        • ADK32565.1
                                        • mibN
                                        		 21758 - 23062 (+) integral membrane ion antiporter
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                                          Biosynthesis information
                                          Annotation changelog

                                          Entry version: next

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2024-07-23
                                          MIBiG v4 annotathon
                                          • (ID: C62OJVVH7XOTOTFZSJT727YU)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 4

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-10-07
                                          Update chemical activity to schema version 2.11
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 3

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-09-15
                                          Cleaned up synonym list
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 2

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2019-10-16
                                          Migrated from v1.4
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 1

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2015-06-12
                                          Submitted
                                          • (ID: 5PRHUX76567WU3QJH6GJRK4W)
                                          • (ID: LOOLDPJUN4VZBEJ3W5R2EHIG)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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