BGC0000529: microbisporicin A2 biosynthetic gene cluster from Microbispora corallina
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Location: 1,656 - 23,062 nt. (total: 21,407 nt).
This entry is originally from NCBI GenBank HM536998.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
RiPP
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000529
Short description microbisporicin A2 biosynthetic gene cluster from Microbispora corallina
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • RiPP (Lanthipeptide)
Loci NCBI GenBank: HM536998.1
Compounds
  • microbisporicin A2
Species Microbispora corallina [taxonomy]
References
Chemical products information
microbisporicin A2 [synonyms: microbisporicin, antibiotic 107891, NAI-107 A2]
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C94H127Cl1N26O26S5
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADK32546.1
  • mibJ
1656 - 2294 (+) MibJ, hypothetical membrane protein
  • Unknown
Sequence-based prediction
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  • ADK32547.1
  • mibY
2291 - 3067 (+) putative ABC permease
  • Transport
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  • ADK32548.1
  • mibZ
3064 - 3966 (+) putative ABC transporter ATP-binding protein
  • Transport
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  • ADK32549.1
  • mibO
3963 - 5207 (+) cytochrome P450
  • Tailoring (Hydroxylation)
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  • ADK32550.1
  • mibQ
5240 - 5629 (+) putative lipoprotein signal peptide-containing protein
  • Resistance/immunity
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  • ADK32551.1
  • mibR
5938 - 6720 (+) putative DNA-binding protein, transcriptional activator
  • Regulation
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  • ADK32552.1
  • mibW
7066 - 7833 (-) putative anti-sigma factor
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  • ADK32553.1
  • mibX
7823 - 8485 (-) RNA polymerase, sigma-24 subunit, ECF subfamily
  • Regulation
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  • ADK32554.1
  • mibA
8616 - 8789 (+) microbisporicin structural preproprotein
  • Scaffold biosynthesis
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  • ADK32555.1
  • mibB
8907 - 12254 (+) lantibiotic dehydratase
  • Scaffold biosynthesis
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  • ADK32556.1
  • mibC
12251 - 13708 (+) lantibiotic cyclase
  • Scaffold biosynthesis
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  • ADK32557.1
  • mibD
13737 - 14420 (+) flavoprotein decarboxylase
  • Scaffold biosynthesis
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  • ADK32558.1
  • mibT
14417 - 15367 (+) ABC transporter ATP-binding domain
  • Transport
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  • ADK32559.1
  • mibU
15345 - 16217 (+) ABC-type multidrug transport system permease component
  • Transport
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  • ADK32560.1
  • mibV
16225 - 17229 (+) hypothetical protein
  • Unknown
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  • ADK32561.1
  • mibE
18028 - 18777 (+) putative lantibiotic ABC transporter permease protein
  • Transport
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  • ADK32562.1
  • mibF
18779 - 19489 (+) putative lantibiotic ABC transporter ATP-binding protein
  • Transport
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  • ADK32563.1
  • mibH
19522 - 21228 (+) tryptophan-5-halogenase
  • Tailoring (Halogenation)
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  • ADK32564.1
  • mibS
21225 - 21761 (+) flavin reductase
  • Tailoring (FADH2 supply for chlorination)
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  • ADK32565.1
  • mibN
21758 - 23062 (+) integral membrane ion antiporter
  • Other enzymatic
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RiPP-specific information
Subclass Lanthipeptide
Cyclic? no
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 5PRHUX76567WU3QJH6GJRK4W, no GDPR consent given).
  • Hidden contributor (ID: LOOLDPJUN4VZBEJ3W5R2EHIG, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
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