BGC0000529: microbisporicin A2 biosynthetic gene cluster from Microbispora corallina
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1,656 - 23,062 nt. (total: 21,407 nt).
This entry is originally from NCBI GenBank HM536998.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
RiPP
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000529
Short description microbisporicin A2 biosynthetic gene cluster from Microbispora corallina
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • RiPP (Lanthipeptide)
Loci NCBI GenBank: HM536998.1
Compounds
  • microbisporicin A2
Species Microbispora corallina [taxonomy]
References
Chemical products information
microbisporicin A2 [synonyms: microbisporicin, NAI-107 A2]
Copy SMILES
C94H127Cl1N26O26S5
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADK32546.1
  • mibJ
 1656 - 2294 (+) MibJ, hypothetical membrane protein
  • Unknown
Sequence-based prediction
copy AA seq
copy Nt seq
  • ADK32547.1
  • mibY
 2291 - 3067 (+) putative ABC permease
  • Transport
Sequence-based prediction
copy AA seq
copy Nt seq
  • ADK32548.1
  • mibZ
 3064 - 3966 (+) putative ABC transporter ATP-binding protein
  • Transport
Sequence-based prediction
copy AA seq
copy Nt seq
  • ADK32549.1
  • mibO
 3963 - 5207 (+) cytochrome P450
  • Tailoring (Hydroxylation)
Sequence-based prediction
copy AA seq
copy Nt seq
  • ADK32550.1
  • mibQ
 5240 - 5629 (+) putative lipoprotein signal peptide-containing protein
  • Resistance/immunity
Sequence-based prediction
copy AA seq
copy Nt seq
  • ADK32551.1
  • mibR
 5938 - 6720 (+) putative DNA-binding protein, transcriptional activator
  • Regulation
Knock-out
Sequence-based prediction
copy AA seq
copy Nt seq
  • ADK32552.1
  • mibW
 7066 - 7833 (-) putative anti-sigma factor
copy AA seq
copy Nt seq
  • ADK32553.1
  • mibX
 7823 - 8485 (-) RNA polymerase, sigma-24 subunit, ECF subfamily
  • Regulation
Knock-out
copy AA seq
copy Nt seq
  • ADK32554.1
  • mibA
 8616 - 8789 (+) microbisporicin structural preproprotein
  • Scaffold biosynthesis
Knock-out
copy AA seq
copy Nt seq
  • ADK32555.1
  • mibB
 8907 - 12254 (+) lantibiotic dehydratase
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • ADK32556.1
  • mibC
 12251 - 13708 (+) lantibiotic cyclase
  • Scaffold biosynthesis
Sequence-based prediction
copy AA seq
copy Nt seq
  • ADK32557.1
  • mibD
 13737 - 14420 (+) flavoprotein decarboxylase
  • Scaffold biosynthesis
Knock-out
Sequence-based prediction
copy AA seq
copy Nt seq
  • ADK32558.1
  • mibT
 14417 - 15367 (+) ABC transporter ATP-binding domain
  • Transport
Sequence-based prediction
copy AA seq
copy Nt seq
  • ADK32559.1
  • mibU
 15345 - 16217 (+) ABC-type multidrug transport system permease component
  • Transport
Sequence-based prediction
copy AA seq
copy Nt seq
  • ADK32560.1
  • mibV
 16225 - 17229 (+) hypothetical protein
  • Unknown
Knock-out
Sequence-based prediction
copy AA seq
copy Nt seq
  • ADK32561.1
  • mibE
 18028 - 18777 (+) putative lantibiotic ABC transporter permease protein
  • Transport
Knock-out
Sequence-based prediction
copy AA seq
copy Nt seq
  • ADK32562.1
  • mibF
 18779 - 19489 (+) putative lantibiotic ABC transporter ATP-binding protein
  • Transport
Knock-out
Sequence-based prediction
copy AA seq
copy Nt seq
  • ADK32563.1
  • mibH
 19522 - 21228 (+) tryptophan-5-halogenase
  • Tailoring (Halogenation)
Knock-out
copy AA seq
copy Nt seq
  • ADK32564.1
  • mibS
 21225 - 21761 (+) flavin reductase
  • Tailoring (FADH2 supply for chlorination)
Sequence-based prediction
copy AA seq
copy Nt seq
  • ADK32565.1
  • mibN
 21758 - 23062 (+) integral membrane ion antiporter
  • Other enzymatic
Knock-out
copy AA seq
copy Nt seq
RiPP-specific information
Subclass Lanthipeptide
Cyclic? no
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 5PRHUX76567WU3QJH6GJRK4W, no GDPR consent given).
  • Hidden contributor (ID: LOOLDPJUN4VZBEJ3W5R2EHIG, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Cleaned up synonym list
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.