Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000532.1:
Cluster 1RiPP13480

BGC0000532, mutacin II biosynthetic gene cluster from Streptococcus mutans. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: mutacin II

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
Lanthipeptide

Gene cluster description

mutacin II (BGC0000532). Gene Cluster 1. Biosynthetic class = RiPP. GenBank U40620. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Detailed annotation

mutA leader / core peptide, putative Class II
MNKLNSNAVVSLNEVSDSELDTILGG - NRWWQGVVPDhbVDhaYECRMNDhaWQHVFDhbCC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Literature references

1. Novak J et al. (1994) Isolation and biochemical characterization of a novel lantibiotic mutacin from Streptococcus mutans. J Bacteriol 176(14):4316-20.
2. Chikindas ML et al. (1995) Mutacin II, a bactericidal antibiotic from Streptococcus mutans. Antimicrob Agents Chemother 39(12):2656-60.
3. Woodruff WA et al. (1998) Sequence analysis of mutA and mutM genes involved in the biosynthesis of the lantibiotic mutacin II in Streptococcus mutans. Gene 206(1):37-43.