BGC0000535: nisin A biosynthetic gene cluster from Lactococcus lactis subsp. lactis
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Location: 1 - 15,016 nt. (total: 15,016 nt).
This entry is originally from NCBI GenBank HM219853.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
RiPP
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000535
Short description nisin A biosynthetic gene cluster from Lactococcus lactis subsp. lactis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • RiPP (Lanthipeptide)
Loci NCBI GenBank: HM219853.1
Compounds
  • nisin A
Species Lactococcus lactis subsp. lactis [taxonomy]
References
Chemical products information
nisin A [synonyms: nisin]
Copy SMILES
C143H230N42O37S7
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADJ56352.1
  • nisA
828 - 1001 (+) NisA
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  • ADJ56353.1
  • nisB
1109 - 4090 (+) NisB
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  • ADJ56354.1
  • nisT
4101 - 5903 (+) NisT
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  • ADJ56355.1
  • nisC
5896 - 7140 (+) NisC
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  • ADJ56356.1
  • nisI
7137 - 7874 (+) NisI
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  • ADJ56357.1
  • nisP
7876 - 9924 (+) NisP
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  • ADJ56358.1
  • nisR
9993 - 10679 (+) NisR
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  • ADJ56359.1
  • nisK
10672 - 12015 (+) NisK
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  • ADJ56360.1
  • nisF
12114 - 12791 (+) NisF
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  • ADJ56361.1
  • nisE
12793 - 13521 (+) NisE
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  • ADJ56362.1
  • nisG
13508 - 14152 (+) NisG
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  • nisB
(external)
  • Tailoring (Dehydration)
Activity assay
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Sequence-based prediction
  • nisG
(external)
  • Resistance/immunity
Activity assay
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Sequence-based prediction
  • nisE
(external)
  • Resistance/immunity
Activity assay
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Sequence-based prediction
  • nisF
(external)
  • Resistance/immunity
Activity assay
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Sequence-based prediction
  • nisK
(external)
  • Regulation
Activity assay
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Sequence-based prediction
  • nisR
(external)
  • Regulation
Activity assay
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Sequence-based prediction
  • nisI
(external)
  • Resistance/immunity
Activity assay
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Sequence-based prediction
  • nisC
(external)
  • Tailoring (Unknown)
Activity assay
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Sequence-based prediction
  • nisA
(external)
  • Precursor biosynthesis
Activity assay
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Sequence-based prediction
  • nisT
(external)
  • Transport
Activity assay
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Sequence-based prediction
RiPP-specific information
Subclass Lanthipeptide
Cyclic? yes
Peptidases
  • ADJ56357.1
Precursor genes
>ADJ56352.1
Leader sequence: MSTKDFNLDLVSVSKKDSGASPR
Core sequences:
  • ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK
Crosslinks:
  • 3x7 (Thioether)
  • 13x19 (Thioether)
  • 23x26 (Thioether)
  • 8x11 (Thioether)
  • 25x28 (Thioether)
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AFPZZIRFJ6UKQGITNCDTFELO, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
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