Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000538.1:
Cluster 1RiPP17610

BGC0000538, nisin Z biosynthetic gene cluster from Lactococcus lactis. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: nisin Z

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
Lanthipeptide

Gene cluster description

nisin Z (BGC0000538). Gene Cluster 1. Biosynthetic class = RiPP. GenBank Z18947. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Detailed annotation

nisin leader / core peptide, putative Class I
MSTKDFNLDLVSVSKKDSGASPR - IDhbDhaIDhaLCDhbPGCKDhbGALMGCNMKDhbADhbCNCDhaIHVDhaK

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Homologous known gene clusters

Literature references

1. Engelke G et al. (1992) Biosynthesis of the lantibiotic nisin: genomic organization and membrane localization of the NisB protein. Appl Environ Microbiol 58(11):3730-43.
2. Immonen T et al. (1995 TI) The codon usage of the nisZ operon in Lactococcus lactis N8 suggests a non-lactococcal origin of the conjugative nisin-sucrose transposon. DNA Seq 5(4):203-18.