LOCUS       BGC0000539             11740 bp    DNA     linear   BCT 25-JUL-2016
DEFINITION  Staphylococcus warneri genes for putative response regulator, NukA,
            NukM, NukT, NukF, NukE, NukG, NukH, putative plasmid
            replication-associated protein, putative plasmid
            replication-associated protein, replication protein, partial and
            complete cds.
ACCESSION   BGC0000539
VERSION     BGC0000539
KEYWORDS    .
SOURCE      Staphylococcus warneri
  ORGANISM  Staphylococcus warneri
            Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
COMMENT     On Mar 9, 2010 this sequence version replaced AB121757.2.
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 19:48:26
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11740
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..11740
                     /db_xref="taxon:1292"
                     /mol_type="genomic DNA"
                     /organism="Staphylococcus warneri"
     protocluster    1..11740
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1900:4654]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1901..4654
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..11740
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..11740
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000539"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..11740
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /subregion_numbers="1"
                     /tool="antismash"
     regulatory      complement(43..70)
                     /regulatory_class="terminator"
     CDS             complement(156..899)
                     /codon_start=1
                     /function="unknown"
                     /note="ORF1"
                     /product="putative response regulator"
                     /protein_id="BAC98758.1"
                     /transl_table=11
                     /translation="MKKINAIIIDDNASTREDLKVNLSYFSFVSCKGTFSEYIEAKNTL
                     DKKDIDLIFLKINTNNNKFIDIANNINSIHKHIQIVFLSSDSKHAHKSFEAHPFDYLIQ
                     PVEPIKLEKCLLHFKNRCRKKFDLNNLKNRKIAIKKGKSLYFLEIDKITTAECCGRKII
                     ITLDDKETVSYNGSLKYLEKKLYSYGFILVSRSLLIPLKSIKNIIFDKHSKCYILKSIK
                     NNTVKITPEKYKKVKQTLSEFNWII"
     regulatory      complement(910..913)
                     /regulatory_class="ribosome_binding_site"
     regulatory      complement(1196..1229)
                     /regulatory_class="terminator"
     gene            complement(1326..1499)
                     /gene="nukA"
     CDS             complement(1326..1499)
                     /codon_start=1
                     /gene="nukA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /note="prepronukacin ISK-1"
                     /product="NukA"
                     /protein_id="BAC98759.1"
                     /sec_met_domain="L_biotic_A (E-value: 4.1e-29, bitscore:
                     89.9, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENSKVMKDIEVANLLEEVQEDELNEVLGAKKKSGVIPTVSHDCH
                     MNSFQFVFTCCS"
     CDS_motif       complement(1410..1499)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MENSKVMKDIEVANLLEEVQEDELNEVLGA"
                     /locus_tag="nukA_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(1326..1409)
                     /prepeptide="core"
                     /locus_tag="nukA_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="3.80"
                     /molecular_weight="2923.4"
                     /monoisotopic_mass="2921.4"
                     /core_sequence="KKKSGVIPTVSHDCHMNSFQFVFTCCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MENSKVMKDIEVANLLEEVQEDELNEVLGA"
                     /leader_location="[1409:1499](-)"
                     /alternative_weights="2941.4"
                     /alternative_weights="2959.4"
                     /alternative_weights="2977.5"
     regulatory      complement(1509..1512)
                     /regulatory_class="ribosome_binding_site"
     regulatory      complement(1538..1543)
                     /regulatory_class="minus_10_signal"
     regulatory      complement(1561..1566)
                     /regulatory_class="minus_35_signal"
     regulatory      1845..1850
                     /regulatory_class="minus_35_signal"
     regulatory      1868..1873
                     /regulatory_class="minus_10_signal"
     regulatory      1885..1888
                     /regulatory_class="ribosome_binding_site"
     gene            1901..4654
                     /gene="nukM"
     CDS             1901..4654
                     /codon_start=1
                     /function="posttranslational modifications of prepronukacin
                     ISK-1"
                     /gene="nukM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     711.6; E-value: 2.7e-215)"
                     /gene_kind="biosynthetic"
                     /product="NukM"
                     /protein_id="BAC98760.2"
                     /sec_met_domain="LANC_like (E-value: 1.7e-78, bitscore:
                     253.3, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="DUF4135 (E-value: 1.3e-92, bitscore:
                     300.4, seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNIKVEQFRGFSNFILKKYSKQELNTLIDWNYLRSIILDICGKS
                     LIVLINEKRLNKKLNGNTPEERYKYFDEELCEKGIIYEELNKSYPSIINDLEQTLNSYF
                     SFLKEIENKFNQEKKKLLEANLIKTEKETICHISILGDLHGGKAVTKVTTDKSQLLYKP
                     RSLENDSFFLEFLEFMYSFQKNEISTYYKYKFIDYKDHGWMEYIEKQPTSKNKINMYYK
                     RLGYLLSIGYLLNISDLHFENILCSSNFPILIDLETIFHTSIYESKFRNLATKNIEDKA
                     ANSVFATGMLPISKKDKKYGGDISGILGGVFNKHERTISNPNRDDIKFEKRLVRVKRND
                     HIPFYMENDKKRRFSPEVFIEDIQEGFKYGYELFLNNRKEILHYIKKTSSEVEVRILPR
                     STIEYSVLIQAAKSPLYANKRKSLFNKLEEYGENLLSDKLINSEIKQIETLSVPYFYTK
                     VQSVSVKDIKNNTVHHLLKNPLNVFLEKTQRYSLKDLLFQCKLIKFSLESQNKLFIDGN
                     GFINYEYEIVNSDNIDDAIDNLVSIIINNAVIDEKDGSVNWMNLGISKEEEIIFESLSD
                     DLYKGLSGIGIALLKYYEINKNLKDMSRLKKILSSIYSSILSNINTNSSKEKDLSFFNG
                     EIGKIAFLYKYQIEFKENCDSSKNYMKHILGIILSSEFEMNDIIAGLPGIISYLYNQEI
                     FSKELVIMGDRLLKDLDNNPTMASYAHGKSGVMVSLLYLYDLTKDKKYLVKFHQEWKKE
                     NTLKLEIGWKDVRQNEETYSVSWCNGVTGQLISRLVALEIHDKVKIFDAVNKKLMQKEI
                     EELLYLLKEEGLEQNNFCLCHGVMGNLLVLNYYQKKFENTNIHLANKIDSHFYSVANFG
                     LNKGWICGLGNNFYSFSIMTGISGILYAFLKYKTKDTELGILLPNI"
     regulatory      4658..4661
                     /regulatory_class="ribosome_binding_site"
     gene            <4676..6760
                     /gene="nukT"
     CDS             <4676..6760
                     /codon_start=1
                     /function="protease; ABC transporter; cleavage of the
                     leader peptide and export of mature nukacin ISK-1"
                     /gene="nukT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 153.1; E-value:
                     1.8e-46)"
                     /gene_kind="transport"
                     /note="The nukT gene is presumably translated from TTG as a
                     start codon."
                     /product="NukT"
                     /protein_id="BAC98761.2"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.8e-38, bitscore:
                     119.9, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LKIALQNSDQDCLLACYSMILSYFGKNVSINSLYKREMIPPDGLS
                     ISYLKELNIKYELNMKVYRIKDKEKTFRVISKIKKPIIVHWDLNHFVIVKNVKKKHIEI
                     VNPEIGKVKISKEMFLEHFSNVLLMFDPKSDFTKDKEKIEFFDDLKSVLMNKNIILFSF
                     SVMLAQIVALIFSIVVRDIINQKYTYLISLSMLLMMIIIQIFSLVFKQKAQIKENKIYE
                     KIISYNMFEGLFNKPLLYFRNSTIGTLMEKINIKTTIRDNILLKILPSFLNFFSVTVLF
                     IYLLTVSLLLSLLLLGMSIIYLLISVFIYIKKNQLNIEYMQRTIQFSSLAQESLSQIDQ
                     IKAQAQESSTINNWKEKSWNIVNSYNSILKIEGLSYTFNQIFNYSSIILLMIFGIHLTK
                     YGNITIADLILFQSGMSIFSSSVSQLQDITFEISKIKVSGEKINDLFLKNNTKRKVIEQ
                     KSNNALSLKNVTFGFDEKAPILKNITFQVKKGEKVAIVGDSGSGKSTMLNVLLGLYTCD
                     GEVVYGYRDFRKITGVVLQNMTLSKQSIYNNLVDEGNDSNMQKLNQILYDVNIINLINS
                     LPNKIYSSVFQNGKNLSGGQIQRLLIAKSLFNKKLIFWDEAFSSLDNYNRINIYRNVLK
                     NSQYSDKTIVLISHHLDVLSYVDKVMFIENGNAFFGTHNELIKNNKNYRRFLDTANTNN
                     "
     regulatory      6761..6764
                     /regulatory_class="ribosome_binding_site"
     gene            6773..7648
                     /gene="nukF"
     CDS             6773..7648
                     /codon_start=1
                     /function="immunity to the lantibiotic nukacin ISK-1"
                     /gene="nukF"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 171.6; E-value:
                     3.7e-52)"
                     /gene_kind="transport"
                     /note="ABC transporter (ATP-binding domain)"
                     /product="NukF"
                     /protein_id="BAC98762.1"
                     /transl_table=11
                     /translation="MINNIVQTQNLTKKFSDSYSVDNLSLNIGSKEIYGFLGPNGAGKS
                     TTMKMLLGLMQPTKGNIKIFNQDISKNRDEILMHVGALIEEPSYYKNLTGLENLQVIQR
                     LLNLPSKNVKEALKIVRLTEHKDKLVKNYSLGMKQRLGIALAIVKFPKLLILDEPTNGL
                     DPSGIQEIRELIKSFPKTYGMTVLISSHLLSEIEHMANTVGIINRGKLLFEGKLTELEE
                     QNKILINTNNNSESINLLQSKGYNLENNEKPLLLDTTQKDISTAVKLLVNNKFEIYQVQ
                     SVQKSLEENL"
     regulatory      7668..7671
                     /regulatory_class="ribosome_binding_site"
     gene            7681..8433
                     /gene="nukE"
     CDS             7681..8433
                     /codon_start=1
                     /function="immunity to the lantibiotic nukacin ISK-1"
                     /gene="nukE"
                     /note="ABC transporter (transmembrane domain)"
                     /product="NukE"
                     /protein_id="BAC98763.1"
                     /transl_table=11
                     /translation="MLKAINLEFFKMRRRKFILPILLITFVGILWFCAIAIKELNITDT
                     KYGIYMLISNILTIDSMIYPILIGILCSRLADIEHQGKTFQLLNTSKQSVFNLFTSKVG
                     VSLIILFVIDIIQLTTILLIANSHNISLKLEIISKFMLSFIIASFFLILIHMALSFFFE
                     KQSVSIVSALVGSFLGLVTGGMLPSYIKIFLPWQYYSLLNPVHKKMVHKGYEYSNNDYY
                     FIYIFISILVIVILFFIIKALIKRRDLN"
     regulatory      8417..8420
                     /gene="nukE"
                     /regulatory_class="ribosome_binding_site"
     gene            <8430..9167
                     /gene="nukG"
     CDS             <8430..9167
                     /codon_start=1
                     /function="immunity to the lantibiotic nukacin ISK-1"
                     /gene="nukG"
                     /note="ABC transporter (transmembrane domain); The nukG
                     gene is presumably translated from TTG as a start codon."
                     /product="NukG"
                     /protein_id="BAC98764.1"
                     /transl_table=11
                     /translation="LISLLSIELRKLQNNYILIFLLVFNILSVSIGSMIFYFNQSAFPN
                     SNNRDLILWGQETLYTSQLFFPILIGVLCSISWQFEESNNNWMRMKTIPLKESKIVLSK
                     FLSLFLLTLLNQIIFFVLFCISASIVNVSLEGLLKFLYWDFIGWIGTASIVAIQLYLSV
                     ATRNFTFSILISTIGGVLGLLTLFISNFIFKIFPYSQITVGVRARSLMNFTFSEMLLFL
                     IINVAYITVFLTLTTLKLKKREG"
     regulatory      9159..9162
                     /gene="nukG"
                     /regulatory_class="ribosome_binding_site"
     gene            9174..9452
                     /gene="nukH"
     CDS             9174..9452
                     /codon_start=1
                     /function="immunity to the lantibiotic nukacin ISK-1"
                     /gene="nukH"
                     /note="accessory protein associated with NukFEG complex"
                     /product="NukH"
                     /protein_id="BAC98765.2"
                     /transl_table=11
                     /translation="MKRKDYLFFVIALLPLISLLLQLMKISLIHNYQSFFSIVNIICIL
                     FTIAYSIILVINSKKKNNLQKTILILSIIYILTLIFISFGVIINMFN"
     regulatory      9494..9527
                     /regulatory_class="terminator"
     CDS             complement(9561..9761)
                     /codon_start=1
                     /function="unknown"
                     /note="ORF8"
                     /product="putative plasmid replication-associated protein"
                     /protein_id="BAC98766.1"
                     /transl_table=11
                     /translation="MAGFLDDIDTSSVKYTENYKPISKSTTMRVDTNLKKRLSQMALDQ
                     DTSIKAIVDNVLNEFLEKKGY"
     CDS             complement(9767..10417)
                     /codon_start=1
                     /function="unknown"
                     /gene_functions="other (smcogs) SMCOG1157:hypothetical
                     protein (Score: 123.3; E-value: 2.1e-37)"
                     /gene_kind="other"
                     /note="ORF9"
                     /product="putative plasmid replication-associated protein"
                     /protein_id="BAC98767.1"
                     /transl_table=11
                     /translation="MKRTYVEAPEENESFIDMLRTGNLENSMIRLSSKLSLLPADSSLA
                     NLSDIISKTDILKKRYILKNVVEKIREMYDFDHIFIDVPPTINSDFTNNAVYASDYILM
                     VFQTQQSAYESSLSFVNFLRDRKNESNLPFELIGAVPVLIKRSGKVDEKILNMSKTAFS
                     QALFENQIYQRERIKKFGAEGIRNKDMHDKKVIHMFNKVYIELVDRIQVIESE"
     gene            11192..>11740
                     /gene="rep"
     CDS             11192..>11740
                     /codon_start=1
                     /function="plasmid replication"
                     /gene="rep"
                     /note="truncated"
                     /product="replication protein"
                     /protein_id="BAC98768.1"
                     /transl_table=11
                     /translation="MTKQRFTKLYKFLFEDSTFNKLSIKAKLLYALLTERQNLSKLSAK
                     QHGIQSQFIDDNGRLFSIYTNKELMNIINISEPTVINLKKQLIAFGLLEEIRLGKNKPN
                     RLYPKKPYDEYFYVHDVDEFYRLPHSLFSNPKYKNLKAETIVAYAVYLSRYEYSVYKNH
                     FSDKSGEIYCHFSNEKMAEF"
ORIGIN
        1 aagctttatc tttaaacttt gaacaaaaaa tcaaatgttc cccccccatc tcttgtaaag
       61 gagatggggg aactagatta taagttgttt tcaaaataca atataacgtt atatctgaat
      121 tttctaaaac tttaattttt tgtaatagaa ccagattaaa taatccagtt gaattcactt
      181 aatgtttgct ttactttttt atacttttct ggagtgattt taaccgtatt attcttaatc
      241 gatttcaaaa tatagcattt actatgctta tcgaatatta tatttttaat actttttaaa
      301 ggaataagta atgacctact tactaaaata aatccataag aatagagttt tttttctaaa
      361 tattttaagg agccattata agaaactgtt tctttgtcat ccaaagtgat aattattttt
      421 ctaccgcaac attctgctgt tgtaatttta tcaatttcta aaaaatataa agatttcccc
      481 tttttaatgg cgatttttct gtttttaaga ttgttaagat cgaatttttt tctgcatcta
      541 tttttgaaat gaagtaagca cttctccaat ttaataggct ctactggttg tattaaatag
      601 tcaaaaggat gagcttcaaa acttttatgt gcgtgtttgg aatcagaaga tagaaaaact
      661 atttgaatat gtttatgtat agaattgata ttattggcta tatctataaa cttgttgtta
      721 tttgtattta tttttaaaaa tattaagtct atatctttct tatctagggt atttttggct
      781 tcaatatatt cactaaatgt acctttacat gaaacaaatg agaagtaaga tagatttact
      841 tttaaatcct ctctagtact tgcattatcg tctataataa tagcatttat ttttttcata
      901 aaatcaattt tcccattcct ttatcaataa aaaattaaaa ccaaccttac ttcattaata
      961 tatcacaatt atttttttaa atcattatta ttaaatgaac tttaaaattt ttttaaattg
     1021 atagattgta agattatttt gtaaagtata tctgctagac ttcaagtaat tgttgccaat
     1081 aaattgcctt cgatgaagtt atcttaataa aagctggaaa gaacaaaata ttaaggtttc
     1141 aatactctcc aaaatacaat aactaaagac actatatatg ttttacggtt cataaaaaat
     1201 ccgtagttct tttcaaaact acggattttc gccatgccat aatattagta tcatgttaat
     1261 caataaaaaa actaaagtaa gtatcactta aagttatttt tactgatttt acaacattcc
     1321 cctttttatg aacaacaagt aaatacaaat tggaaagaat tcatatggca atcgtgtgac
     1381 acagttggga ttactcctga ctttttctta gctcctaaga cttcattcaa ttcatcttct
     1441 tgaacctctt ctaataaatt tgctacttca atgtccttca taactttaga attttccatg
     1501 tttgttacct cctaaattta atatttgtta caagtttaat atcacatgat atttacaaag
     1561 tgtaaaattg tataaaccac ttatttatat aattaaaatt tatatttaga gtgataaagt
     1621 ggttttctat atgaataaaa taaaaatttg aaacttacaa ttttgttagt tttaggtttt
     1681 tccgtttctg ctgcaaaatt tatcttgtag tatgaggtta gattaccaat attagaagta
     1741 aagcgaaatt gtagcaagct agttattttt ataacactgt aaaagaggaa tgttcataca
     1801 catcaaaact aatttcaaac gtcgaaaaga tatgttaaag caaatttata taatgcgtta
     1861 tatgaattat gatagttaat aataggagat gatattaact atgaacaaca ttaaagttga
     1921 acaatttaga ggattttcaa attttatttt aaaaaaatac tctaaacaag aacttaacac
     1981 attaattgat tggaactact taagatctat tattctagat atttgtggaa aatcattgat
     2041 tgttttaatt aatgaaaaaa gattaaacaa aaaactcaat ggaaatactc ctgaagaacg
     2101 ctataaatat tttgatgaag aattatgtga aaaagggatt atatatgaag agttaaataa
     2161 aagttatcca tcaataataa atgatttaga gcaaacttta aactcatatt tttcgttttt
     2221 gaaagaaatc gaaaataaat tcaatcaaga aaaaaagaaa cttttagaag ccaatttaat
     2281 aaaaactgaa aaagaaacga tttgtcatat cagtatttta ggagatttac atggaggtaa
     2341 agcggtgact aaagtaacca ctgataaatc tcaattatta tataaaccta ggtcattaga
     2401 aaatgatagt ttctttttag aattcttaga atttatgtac agttttcaaa aaaatgaaat
     2461 atcaacatac tataagtata aattcataga ttataaagac cacggttgga tggaatatat
     2521 agaaaagcaa cctacctcta aaaataaaat aaatatgtat tacaaaagat tgggatattt
     2581 attgtctata ggatatttat taaatataag tgatttacat ttcgaaaata tactgtgttc
     2641 cagtaatttt ccaatattaa ttgatttaga aactatattt catacgtcca tatatgaatc
     2701 aaaatttcgt aatttagcta caaagaatat agaagataaa gctgctaatt ctgtattcgc
     2761 taccggaatg ttaccgatat ccaaaaaaga caaaaaatac ggtggagata taagtggaat
     2821 attaggtgga gtatttaata aacacgaaag aactataagt aatcctaata gagatgatat
     2881 aaaattcgaa aagagattag taagagttaa aagaaatgat catatcccat tttatatgga
     2941 aaatgataaa aaaaggagat tttctcccga agtatttata gaagatattc aagaaggctt
     3001 taaatatggt tacgaattat ttcttaacaa tagaaaagaa atactacatt atataaagaa
     3061 aacgtcatca gaagtagaag tgagaatttt accaagaagt acaattgagt actcagtatt
     3121 aatacaagct gctaaatcac ctctttatgc aaataagcga aagagcttgt ttaacaaact
     3181 agaagagtac ggtgaaaatt tattaagtga taagttaata aattcagaaa taaaacaaat
     3241 agaaactctt tcagtaccct atttttatac taaggtccaa agtgtttcgg taaaagatat
     3301 taaaaataat acggtacatc acttattgaa aaacccactc aatgtatttt tagaaaaaac
     3361 gcaaagatat tctttgaaag atttgttgtt tcaatgtaaa ctaataaaat tttcattaga
     3421 aagtcaaaat aaattattta ttgatggtaa tggatttata aattatgaat atgaaatagt
     3481 aaattcagac aatattgacg atgcaatcga caatttagta agcattataa ttaataatgc
     3541 agtcatagat gaaaaagatg gttctgtaaa ttggatgaat ttaggcatat caaaagaaga
     3601 agaaataata tttgaaagct tgtcagatga cttatataaa ggattgtcag gaataggaat
     3661 agctttatta aaatattatg aaattaacaa aaacttaaaa gatatgagta gactaaaaaa
     3721 aatactaagc agtatttatt cttctatatt aagtaatata aatactaatt ctagtaaaga
     3781 aaaggattta tcttttttta atggtgaaat aggtaaaatc gcatttttat ataaatacca
     3841 gattgaattt aaagaaaatt gcgacagcag taaaaattat atgaaacata ttttagggat
     3901 cattttatct agtgaatttg aaatgaatga cattatagcc ggattaccag gaattatttc
     3961 atatttatat aatcaagaaa tattttctaa agaacttgta ataatgggag atagactatt
     4021 aaaagactta gacaataatc caactatggc tagctacgct cacggtaaaa gtggggtaat
     4081 ggtttcatta ttatatttat atgatttaac taaagacaaa aagtatctag ttaaattcca
     4141 tcaggaatgg aaaaaagaaa acacattaaa attggaaata ggatggaaag atgtaagaca
     4201 aaatgaagaa acctactctg tatcatggtg taacggagtt acaggacagt taataagtag
     4261 actagttgct ttagaaattc atgataaagt aaaaatattt gatgctgtaa ataaaaagtt
     4321 aatgcaaaaa gaaattgaag aattacttta tttattgaaa gaagaaggat tagaacaaaa
     4381 taatttttgc ctatgtcatg gcgtcatggg aaatttactg gttttaaatt actatcaaaa
     4441 aaaatttgaa aatacaaaca ttcatttagc caataaaata gacagtcatt tttattcagt
     4501 agctaatttt ggtttaaata aaggatggat atgtggctta ggaaataact tttactcttt
     4561 tagcattatg acaggaatat caggtatttt atatgctttt ttaaagtata aaactaagga
     4621 tactgaatta ggtatattgt taccaaacat ttagtttgga agaaggtgat gacaattgaa
     4681 aatcgcatta caaaatagtg accaagactg tctattagcg tgttattcaa tgattttgag
     4741 ttattttggt aaaaatgtat ctataaatag tctttacaaa agagagatga taccacctga
     4801 tggtctatca atatcttatt tgaaagaatt aaatattaag tacgaactta atatgaaagt
     4861 atatagaatt aaagataaag aaaaaacatt ccgagtaata agtaaaataa agaaaccaat
     4921 aattgttcat tgggatttaa atcattttgt catagtaaaa aacgttaaaa aaaaacatat
     4981 agaaatagtc aacccagaga taggaaaagt aaaaatttca aaagagatgt ttttggaaca
     5041 tttttcaaat gttctattaa tgtttgatcc taagagcgat tttacaaaag ataaagaaaa
     5101 aattgagttc tttgacgatt taaaaagtgt tttaatgaat aaaaacataa ttcttttttc
     5161 attttcagtg atgttagctc aaattgtagc tctaattttt tcaatagttg ttagagatat
     5221 aataaatcaa aaatatacat acctaatatc attatcaatg ctattaatga tgattattat
     5281 tcaaatattt tctttagttt ttaagcaaaa agctcaaatt aaagagaata aaatatatga
     5341 aaaaatcatt tcctataaca tgtttgaagg attatttaac aagcccttat tatactttag
     5401 aaatagcaca ataggtactt tgatggaaaa gataaatata aagactacta taagggacaa
     5461 catactgctt aaaatattgc catcattctt aaacttcttt tccgttacgg tattgtttat
     5521 atatttgtta actgtatcac tgctattatc attattactt ttaggtatgt ccattatata
     5581 tttgttaatc agtgtgttta tatatataaa gaaaaatcaa ttgaatattg agtatatgca
     5641 gagaactata caatttagtt ctttagctca agaatcatta agtcaaattg atcaaattaa
     5701 ggcccaagct caagaatcat caacaataaa taactggaaa gaaaaaagtt ggaatatagt
     5761 taactcttat aattcaattt tgaaaattga aggattatca tatactttta atcaaatttt
     5821 caattacagt agcataatac ttttaatgat ttttggtatt catcttacaa aatacggaaa
     5881 tataaccata gcagatttaa tcttatttca atccggtatg tctatattta gttcatctgt
     5941 ttcacaacta caagacatta cgtttgaaat atcaaaaatt aaagtgtccg gcgagaaaat
     6001 caatgactta tttttaaaaa ataatactaa aagaaaagta atcgagcaga aatctaataa
     6061 tgctttatca cttaagaatg ttacttttgg ttttgatgaa aaagccccta tattgaaaaa
     6121 cattactttc caagtaaaaa aaggtgaaaa agtagctata gtaggagact ccggatcagg
     6181 taaaagtact atgttaaatg ttctgttagg tctctataca tgtgatggtg aagtagttta
     6241 cggttataga gattttagga aaataacagg ggtcgtctta cagaatatga cgttaagtaa
     6301 acaatctatt tataataatt tggtggatga aggaaatgat agcaatatgc aaaaattaaa
     6361 ccaaatacta tacgatgtta atattataaa cttgataaat tctttaccta ataaaatata
     6421 ttctagtgta tttcaaaatg gaaaaaatct atctggtggt caaattcaaa ggctattaat
     6481 tgctaaatct ctatttaata aaaaattaat tttttgggat gaagctttta gcagtttgga
     6541 caattacaat cgtataaata tatatagaaa tgttttgaaa aatagtcaat atagcgataa
     6601 aactatagta ctcataagtc accatctaga tgttttatca tatgtcgaca aagtaatgtt
     6661 tattgaaaac ggaaacgctt tttttggaac acataatgaa ttaattaaaa ataataaaaa
     6721 ttatagaaga ttcttagata ctgccaatac taataattaa ggagattcaa ttatgattaa
     6781 caatattgta caaacccaaa atttaacaaa aaagttttca gatagttatt cagtagacaa
     6841 tctatcacta aatattggtt cgaaagaaat atatggattt ttaggtccaa atggtgctgg
     6901 taaaagtact acaatgaaaa tgttactagg tctcatgcaa ccaactaaag gtaatattaa
     6961 aatattcaat caagatattt caaaaaatag agatgagata ttaatgcatg taggggcatt
     7021 aattgaagaa ccttcttatt ataaaaattt aactggttta gaaaatttgc aagttattca
     7081 aagattacta aacttacctt ctaaaaatgt taaagaagct ctgaaaattg tacgtttaac
     7141 tgaacacaag gataaattag tcaaaaatta ttcattaggt atgaaacaaa ggttaggtat
     7201 tgctttagct atagtaaaat ttccaaaact attgatatta gatgaaccta ctaacggctt
     7261 agatccttct ggtatacaag aaattagaga attaataaaa tcttttccaa aaacttatgg
     7321 aatgactgta cttatatcta gtcatttatt atctgaaatt gaacatatgg ctaatacagt
     7381 aggtatcatc aatagaggga aactattgtt tgaaggaaag ttaacagaat tagaagaaca
     7441 gaacaaaata ttgataaata ctaacaataa cagtgagagt ataaacttgc ttcaatcaaa
     7501 aggatataat ctagaaaata atgaaaaacc tctcctatta gatacaactc aaaaagatat
     7561 atctacagcc gttaaattgt tagttaataa taagttcgaa atttaccaag tacaatcagt
     7621 tcagaaaagt ttagaagaaa atttatagaa ataactaatg atggaaagga atatttataa
     7681 atgttaaaag ctataaattt agaatttttc aaaatgcgga gaagaaaatt tatccttcca
     7741 atactactga ttacctttgt tggtatattg tggttttgtg ctatagcaat taaagagtta
     7801 aatattactg atacaaagta tggtatttat atgctcattt ctaatattct aactatcgac
     7861 agcatgattt atccaatatt aataggtatt ttatgctcaa gacttgcaga tatagaacat
     7921 caaggaaaaa cctttcagtt attaaatact agtaaacaaa gtgttttcaa tttgtttact
     7981 agtaaagttg gtgtttcgct tattatttta tttgtaattg acattataca attaacgacc
     8041 atcttactaa ttgctaattc acataatatc agtttgaaac tagaaatcat ttcaaaattc
     8101 atgctaagtt ttataattgc tagtttcttc ttaatattaa ttcatatggc actttctttc
     8161 ttttttgaaa aacaatcagt tagcattgta tcagcattag taggaagttt tttaggatta
     8221 gtaacaggag ggatgttgcc ttcatatatt aaaatatttt tgccttggca atattattca
     8281 ttactaaatc cagttcataa aaagatggtt cacaaaggat atgaatattc aaataatgac
     8341 tattatttta tttacatttt tatttctatt ctagtaatag taattctttt ctttattatt
     8401 aaagccttaa taaaaaggag ggatttaaat tgatttcttt attaagcata gaattacgca
     8461 aactacaaaa taattatatt ttaatcttct tattagtttt taatatatta agcgtatcta
     8521 taggaagtat gatattttat tttaatcaaa gcgcttttcc taattcaaat aatagagatt
     8581 taatattgtg ggggcaagaa actttatata cttcacaact tttctttccc atactgatag
     8641 gtgttttatg ttcaataagt tggcaatttg aggagtctaa taataattgg atgagaatga
     8701 aaactatacc tttaaaagaa agtaagatag ttttatcaaa atttttatct cttttcttac
     8761 ttactttact aaatcaaatt atattttttg tattattttg tatctcagcc tcaatagtaa
     8821 atgtatcctt ggaaggatta cttaaatttc tatactggga ctttataggt tggataggta
     8881 cagcatctat tgttgctata caattatatt tgtcagttgc gactagaaat ttcactttct
     8941 caattttaat atcaactatt ggtggtgtac taggtcttct aacattgttt attagcaatt
     9001 ttatttttaa aatatttcca tattcacaaa ttacagttgg tgtgagagcc agatctttga
     9061 tgaacttcac tttttcagaa atgttacttt ttcttataat aaatgtagct tatataacag
     9121 tttttttgac acttactact ttaaagctta aaaaaagaga gggttaattt aaaatgaaaa
     9181 gaaaagacta cttatttttt gtaattgcac ttttaccttt aattagtttg ttattacagt
     9241 taatgaaaat ttcacttatc cataattatc aaagtttttt ctctatagtt aatatcatct
     9301 gcatactttt tactattgct tattcaatta ttttagttat taatagcaag aaaaagaata
     9361 atttgcagaa aacaattctt attttgtcta ttatctatat attaacttta atttttatct
     9421 cttttggagt aataattaat atgtttaatt aaaataattt taatagcaaa atactatcaa
     9481 aaattttccc acataaaaag tcacgataaa tttatcgtga ctttttaatt gctattcatt
     9541 tttacggata ctatgccagt tcaataacct tttttttcta aaaactcatt taaaacatta
     9601 tcaacaatcg ctttaataga tgtatcttga tctaatgcca tttgacttaa acgttttttt
     9661 aaatttgtat ccacacgcat cgtagtactt ttagaaatag gtttataatt ttcagtatat
     9721 ttaactgacg aagtatctat atcatctaaa aatcctgcca ttattttcac tcactttcaa
     9781 tcacttgtat tctatctacc aattctatat aaactttatt aaacatgtgt attacttttt
     9841 tatcatgcat atctttattt cttataccct cagcaccaaa ttttttaatt ctttctcttt
     9901 gataaatttg attttcaaat agagcttgtg aaaatgcagt tttagacata tttaatattt
     9961 tctcatccac ttttccactt cgtttaatca aaactgggac agctccaatc aattcaaaag
    10021 gcaaattcga ttcatttttt ctatctctta aaaagtttac aaaagacaag ctactttcat
    10081 aagctgattg ttgtgtttga aataccataa gaatataatc gcttgcatat acagcattat
    10141 tagtaaaatc agagttaata gtcggtggta catcaataaa aatatggtca aaatcataca
    10201 tttccctaat cttttctact acatttttta aaatatatct tttcttcaaa atatctgttt
    10261 tagaaattat atcagacaaa ttagctaatg aagagtcagc tggtaacaat gataatttag
    10321 acgataaccg aatcatacta ttttctaaat ttccggttct aagcatatct ataaacgatt
    10381 cattttcctc tggcgcttcg acatatgtcc gtttcataat ttgcgtagcg ttcccctgcg
    10441 gatcaaaatc tataagtaat actttcttac catactgctc tgatgctata taagaaagta
    10501 ttgttgctac tgttgtttta cctactccgc ctttaaaatt tccaactgtt attacactca
    10561 aataaaaacc ccctatgtta catgtaacat gttactaatg tttattcttt ctgtctaatt
    10621 taaatcaatt tgctataaat caaaaaagaa ttacttatat atcctatgtt acatgtaaca
    10681 tgttactaat gtttattctt tctgtctagt ttaaatcaat ttgctataaa ttaaaaaaga
    10741 attacttata tatcctatgt tacatgtaac atgttactaa tgtttattct ttctgtctag
    10801 tttaaatcaa tttgctataa attaaaaaag aattacttat atatcccatg ttacatgtaa
    10861 catgttactt aagggaaagt tacaatattc tttgttaatt tttcttaaat ttgttactat
    10921 gaacttaacg ttcattaata tatttaaaaa gcacttaatc gttggggcga ttaagcgctt
    10981 taggtaataa acactatact aacattcact actaaacatt aagaaaagtg ctatctatat
    11041 acatttatat attctggatg ctcaaatttc aatccatttt gtagaatcaa ttgtataata
    11101 taagtaatat caattcaaga aagatatctt aatttaatta gtattgtgat ttattacctc
    11161 aaccctaaat ttatgtgaag aggtatttac tatgactaaa caacgattta caaaactata
    11221 taaattctta ttcgaagatt ccacatttaa caaactatca ataaaagcta aattgcttta
    11281 tgcattatta accgaacgtc aaaacttatc taagttaagt gccaaacaac atggtattca
    11341 atcacaattt attgatgata acggacgttt attctcaatt tatactaata aagaacttat
    11401 gaatataatt aatatatctg aacctactgt tattaaccta aaaaagcaac tcattgcatt
    11461 tggcttatta gaagaaatac gccttggaaa aaataaaccg aatcgcttat atcctaaaaa
    11521 accttatgat gaatatttct atgttcatga tgttgatgaa ttttatcggt taccacattc
    11581 attattttct aatcctaaat ataagaatct taaagctgag acaattgtcg cttacgctgt
    11641 ttacctaagc cgttatgaat atagtgtata caaaaatcat ttttcggata aaagtggtga
    11701 aatatattgc catttttcta atgagaaaat ggctgaattc
//
