Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000539.1:
Cluster 1RiPP111740

BGC0000539, nukacin ISK-1 biosynthetic gene cluster from Staphylococcus warneri. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: nukacin ISK-1

Class-specific details

Biosynthetic class(es):
RiPP subclass:

Gene cluster description

nukacin ISK-1 (BGC0000539). Gene Cluster 1. Biosynthetic class = RiPP. GenBank AB121757. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Detailed annotation

nukA leader / core peptide, putative Class II


Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Homologous known gene clusters

Literature references

1. Sashihara T et al. (2000) A novel lantibiotic, nukacin ISK-1, of Staphylococcus warneri ISK-1: cloning of the structural gene and identification of the structure. Biosci Biotechnol Biochem 64(11):2420-8. doi: 10.1271/bbb.64.2420.
2. Aso Y et al. (2004 TI) Heterologous expression and functional analysis of the gene cluster for the biosynthesis of and immunity to the lantibiotic, nukacin ISK-1. J Biosci Bioeng 98(6):429-36. doi: 10.1016/S1389-1723(05)00308-7.
3. Aso Y et al. (2004) Characterization of a gene cluster of Staphylococcus warneri ISK-1 encoding the biosynthesis of and immunity to the lantibiotic, nukacin ISK-1. Biosci Biotechnol Biochem 68(8):1663-71. doi: 10.1271/bbb.68.1663.