LOCUS       BGC0000546              7976 bp    DNA     linear   CON 11-MAR-2022
DEFINITION  Streptomyces albidoflavus strain J1074 supercont3.1, whole genome
            shotgun sequence.
ACCESSION   BGC0000546
VERSION     BGC0000546
KEYWORDS    .
SOURCE      Streptomyces albidoflavus
  ORGANISM  Streptomyces albidoflavus
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces; Streptomyces albidoflavus group.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            DS999645.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            The organism was changed from 'Streptomyces albus J1074' to
            'Streptomyces albidoflavus' in October 2018.
            Genome Coverage: 14.3X (13.5X Q>20)
            Annotation was added to the scaffolds in March 2010.
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 19:49:35
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 4112716
            Orig. end    :: 4120692
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..2712
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 79.4;
                     E-value: 5.4e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="SSHG_03588"
                     /product="serine/threonine protein kinase"
                     /sec_met_domain="LANC_like (E-value: 1.2e-07, bitscore:
                     20.0, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 2.8e-15, bitscore: 45.6,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="micKC (E-value: 1.8e-226, bitscore: 743.1,
                     seeds: 18, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MYFPQLAYDKRYLPAPPGHGQCGTRHRRTAQHGTARERRRRGGPV
                     NPEYALYSGTDRWFYDTPRRAGRAADGSGNGSDGHRYALARRPAPEGWESAERGDWFSL
                     APAGRQLPAQGWKIHVSATPDNAEEVLETVAGICQERATAFKFLAGPALLLHRNTKYAD
                     RAGSGKFVTVYPATTAACGELAAELADALKGSAGPVVLSDLRWGEGPVHVRYGAFAPRF
                     TRAADGSLVPAVADPAGRLVPDTRGPAFRLPDWVELPDFLRPHAEARAAQGTTDLPYTV
                     ERALHFSNGGGVYAGSHRETGEAVVLKEGRPHAGLAADGADAVTRLQREYAALRALEGL
                     ACVPRVHGLHTVGEHRFLAMEFIPGTPLNTVFARRFPLSAAEPAAEALAEHTAWALRTH
                     QLVTEAVEALHARGIAFGDLHMNNIMVAPDQLSVTLLDFEAATPAAERRPQIVANPAFV
                     APPHLRGTEVDRYALACLRLALFVPLTTLLPLDRDKAAHLAGLAADRYGIDRALFDEAV
                     TELAGPARPEAGPSRGRPPVSATDWPAARDSMVAALLASATPGRDDRYFPGDIAQFATP
                     AGGQSYGYGAAGVLHALHAVGARCEEAEEWLIRTTRRPASGTPTGFYDGLTGIAWTLDR
                     LGHREEALRLAHLVAAEPLDALGPGLHSGAPGVALALRDLADAADDPALGQAADRAEAA
                     ALRPAAPGGKAGLLHGPAGTALLCLRRHARTGEPALLDTAATALREELGRCVPGPDGSL
                     VVSEARRTMPYLGSGSAGIAMVLDDYLAHRPDPAFEEAQTALLRATGSAFYIQPGLFRG
                     VAGLLLHLARTTTPGDRAARTALLTRQTALLDWHALTYQGHLAHPGEQLTRLSMDLSTG
                     TAGVLLALAATHGEPAAHLPFLPPLRRPTDRP"
     subregion       1..7976
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="RiPP"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..7976
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            133..2712
                     /gene="lanKC"
                     /locus_tag="SSHG_RS17985"
                     /old_locus_tag="SSHG_03588"
     CDS             133..2712
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0004672 - protein kinase activity [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]; GO:0006468 - protein phosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 79.5;
                     E-value: 4.9e-24)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015507351.1"
                     /locus_tag="SSHG_RS17985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSHG_03588"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_037629851.1"
                     /sec_met_domain="LANC_like (E-value: 1.1e-07, bitscore:
                     20.1, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 2.6e-15, bitscore: 45.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="micKC (E-value: 7.2e-227, bitscore: 744.5,
                     seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPEYALYSGTDRWFYDTPRRAGRAADGSGNGSDGHRYALARRPA
                     PEGWESAERGDWFSLAPAGRQLPAQGWKIHVSATPDNAEEVLETVAGICQERATAFKFL
                     AGPALLLHRNTKYADRAGSGKFVTVYPATTAACGELAAELADALKGSAGPVVLSDLRWG
                     EGPVHVRYGAFAPRFTRAADGSLVPAVADPAGRLVPDTRGPAFRLPDWVELPDFLRPHA
                     EARAAQGTTDLPYTVERALHFSNGGGVYAGSHRETGEAVVLKEGRPHAGLAADGADAVT
                     RLQREYAALRALEGLACVPRVHGLHTVGEHRFLAMEFIPGTPLNTVFARRFPLSAAEPA
                     AEALAEHTAWALRTHQLVTEAVEALHARGIAFGDLHMNNIMVAPDQLSVTLLDFEAATP
                     AAERRPQIVANPAFVAPPHLRGTEVDRYALACLRLALFVPLTTLLPLDRDKAAHLAGLA
                     ADRYGIDRALFDEAVTELAGPARPEAGPSRGRPPVSATDWPAARDSMVAALLASATPGR
                     DDRYFPGDIAQFATPAGGQSYGYGAAGVLHALHAVGARCEEAEEWLIRTTRRPASGTPT
                     GFYDGLTGIAWTLDRLGHREEALRLAHLVAAEPLDALGPGLHSGAPGVALALRDLADAA
                     DDPALGQAADRAEAAALRPAAPGGKAGLLHGPAGTALLCLRRHARTGEPALLDTAATAL
                     REELGRCVPGPDGSLVVSEARRTMPYLGSGSAGIAMVLDDYLAHRPDPAFEEAQTALLR
                     ATGSAFYIQPGLFRGVAGLLLHLARTTTPGDRAARTALLTRQTALLDWHALTYQGHLAH
                     PGEQLTRLSMDLSTGTAGVLLALAATHGEPAAHLPFLPPLRRPTDRP"
     CDS             2763..2933
                     /locus_tag="SSHG_03589"
                     /product="predicted protein"
                     /transl_table=1
                     /translation="VAVVRPLDTKEYVMALLDLQAMDTPQEEAVGDLATGSQISLLICE
                     YSSLSVTLCTP"
     gene            2802..2933
                     /locus_tag="SSHG_RS17990"
                     /old_locus_tag="SSHG_03589"
     CDS             2802..2933
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611153.1"
                     /locus_tag="SSHG_RS17990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSHG_03589"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_008415578.1"
                     /transl_table=11
                     /translation="MALLDLQAMDTPQEEAVGDLATGSQISLLICEYSSLSVTLCTP"
     CDS             3164..4987
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 273.6; E-value:
                     5.6e-83)"
                     /gene_kind="transport"
                     /locus_tag="SSHG_03590"
                     /product="ABC transporter ATP-binding protein"
                     /transl_table=1
                     /translation="LREAVRRGRGPAALVLAATALGAAAAVTLPLALGRAVDLLIARAD
                     AGSWVLLCTALIATEVATDALVARTGGRTGAATTAWLRRRALAGFLAAPPAATTGTGLP
                     TRLTANALDAGTAPVAAATAAAAGLAPLGGLAGLFLVDPWAGAAFVCGVPLLLLILRAL
                     LRDGRAALTTYQEEQGRMARLLTGALSGAATIAAAGTVRAEERRVLAPLAGMRAAGERT
                     WRVQGRAAGLSGALMPLLVAAVLAVGGVRLVAGHLTPGDLLALSRYAVLAAGAGALAGA
                     VNGWVRAKAGTARVETVTALPPTPHGTRDLPPHGDGTLALHGVHVTRDGVPLLDSVTLT
                     LPGGTTTALVGPSGSGKSLLAAVAGRLTDPDQGTVLLDGTDLRTLSADTLRHAVAYAFE
                     RPALYGATIADAVACGPLPEPDLRRALRRAAADTFTDRLPQGPRTPLPEAPLSGGELQR
                     LGLARAFSRPTRLLILDDATSSLDTVTAHLVARALTDTPGTRLTITHRLTTAAQSDQVV
                     WLDGGRIRGTGPHSVLWRDPAYRAVFGAGAGGDAGAGADTVTDTEARRRSDVRTDVTGD
                     VRTELPTDMRTDLHTGIRTDPRVDTGTGAAE"
     gene            3248..4987
                     /locus_tag="SSHG_RS17995"
                     /old_locus_tag="SSHG_03590"
     CDS             3248..4987
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 266.6; E-value:
                     7.8e-81)"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.2"
                     /locus_tag="SSHG_RS17995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSHG_03590"
                     /product="ABC transporter ATP-binding protein/permease"
                     /protein_id="WP_241094725.1"
                     /transl_table=11
                     /translation="MPLALGRAVDLLIARADAGSWVLLCTALIATEVATDALVARTGGR
                     TGAATTAWLRRRALAGFLAAPPAATTGTGLPTRLTANALDAGTAPVAAATAAAAGLAPL
                     GGLAGLFLVDPWAGAAFVCGVPLLLLILRALLRDGRAALTTYQEEQGRMARLLTGALSG
                     AATIAAAGTVRAEERRVLAPLAGMRAAGERTWRVQGRAAGLSGALMPLLVAAVLAVGGV
                     RLVAGHLTPGDLLALSRYAVLAAGAGALAGAVNGWVRAKAGTARVETVTALPPTPHGTR
                     DLPPHGDGTLALHGVHVTRDGVPLLDSVTLTLPGGTTTALVGPSGSGKSLLAAVAGRLT
                     DPDQGTVLLDGTDLRTLSADTLRHAVAYAFERPALYGATIADAVACGPLPEPDLRRALR
                     RAAADTFTDRLPQGPRTPLPEAPLSGGELQRLGLARAFSRPTRLLILDDATSSLDTVTA
                     HLVARALTDTPGTRLTITHRLTTAAQSDQVVWLDGGRIRGTGPHSVLWRDPAYRAVFGA
                     GAGGDAGAGADTVTDTEARRRSDVRTDVTGDVRTELPTDMRTDLHTGIRTDPRVDTGTG
                     AAE"
     gene            4984..6915
                     /locus_tag="SSHG_RS18000"
                     /old_locus_tag="SSHG_03591"
     CDS             4984..6915
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 123.4; E-value:
                     2e-37)"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018469939.1"
                     /locus_tag="SSHG_RS18000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSHG_03591"
                     /product="ABC transporter ATP-binding protein/permease"
                     /protein_id="WP_003950018.1"
                     /transl_table=11
                     /translation="MTRPRHTDGAPSPLLRPALTFARRRKGPLGALGAWSLLESARTFL
                     TGYAVARALDDGFLAGDVRAGLLWLLALAAAALAGGFADAGVFRALGGVIEPLRDSLVR
                     RVVRATLTRAVASPTPADTARVSRLTAQTEIARDAAGGVLLTVRSFLFTSAGAFTGLAA
                     LSPRLLPLVLIPLAAGLALFAATLRPMAARQRDLLDADEHLAAFAGRTDHAARDIAATG
                     AAPLVTAEAAPLITAEATAASALARWSAVRVTALGLAAHLPVATLLLAAPTLLSTGLTP
                     GELLAALTYVTTALLPAVNALLTALGAAGSRLLVVLHRLLGEEADAADVREEQAHALRA
                     DDGPRAPGAWSKGKADDEVPAIPVPSLPPEPVHGPEPFHAEPSPPGPRPTRGPRPTRPA
                     LPAATLRGLTFAYGPDAAPVLDHLDLTVEPGEHLLVVGPSGAGKSTLLALLAGTAHPRH
                     GQIHLAGHTARHARTLGTAARVLVPQEPYIFEAPLHDNLTYLAPNAPAPRITEAIDTFT
                     LAPLAADPARPLRPDHLTPSERRRIALARAWLTPTPLLLLDEPTAHLDAGARAATELAF
                     ASHPATVITVSHHFPAPEPGQRVLLLDGATPYLGTHASLLRESALYGELAAGLGEPSAM
                     GSRGTAST"
     repeat_region   6946..7218
                     /inference="COORDINATES: alignment:crt:1.2"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=4119723..4119751
                     /rpt_unit_seq="gggaccaaccccgcacgcgcggggagcag"
     gene            complement(<7566..>7976)
                     /locus_tag="SSHG_RS18005"
                     /old_locus_tag="SSHG_03592"
     CDS             complement(7566..7976)
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 56.2; E-value:
                     4.7e-17)"
                     /gene_kind="regulatory"
                     /locus_tag="SSHG_03592"
                     /product="two-component system response regulator"
                     /transl_table=1
                     /translation="LGLAGAGAERAGIGLAGASRGRAALVVLAGAEHPGVLRLAYAAGA
                     LGLVDRDGPANHLATAIRLAAGGGRYVDDGLAMSLLRAMDMPLSPREVRVLSRAAQGDS
                     VAEIARGLCLSHGTVRNYIASATRKVGARNRVD"
     CDS             complement(<7566..>7976)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 56.2; E-value:
                     4.7e-17)"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010643339.1"
                     /locus_tag="SSHG_RS18005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSHG_03592"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_037630570.1"
                     /transl_table=11
                     /translation="LGLAGAGAERAGIGLAGASRGRAALVVLAGAEHPGVLRLAYAAGA
                     LGLVDRDGPANHLATAIRLAAGGGRYVDDGLAMSLLRAMDMPLSPREVRVLSRAAQGDS
                     VAEIARGLCLSHGTVRNYIASATRKVGARNRVD"
ORIGIN
        1 atgtatttcc cacaactcgc ctatgacaag cgttacttac cggcaccacc cggccacggg
       61 cagtgtggaa cccgtcatcg acgcacagca cagcacggca cggcacggga acgcagacgg
      121 cgagggggac cggtgaatcc ggagtacgcg ctctacagcg gtaccgaccg ctggttctac
      181 gacaccccgc gccgggccgg ccgtgcggcc gacggcagcg gcaacggcag cgacggtcac
      241 cgttacgccc tcgcccggcg ccccgctccc gagggctggg agagcgccga gcgcggtgac
      301 tggttctcgc tcgcccccgc cgggcgccaa ctccccgccc agggctggaa gatccacgtc
      361 tccgcgacgc cggacaacgc cgaagaggtc ctggagacgg tcgccgggat ctgccaggag
      421 cgcgccaccg ccttcaagtt cctcgccggg cccgccctgc tgctccaccg caacaccaag
      481 tacgccgacc gcgccggcag cggcaagttc gtcaccgtct acccggccac caccgccgcc
      541 tgcggcgaac tggccgccga actcgccgac gccctcaagg gcagcgcggg accggtcgtc
      601 ctcagcgacc tgcgctgggg cgagggcccg gtccacgtcc gctacggcgc cttcgcgccc
      661 cgcttcaccc gcgccgccga cggctccctg gtcccggcgg tggccgaccc ggccggccgc
      721 ctcgtcccgg acacccgcgg ccccgccttc cgcctccccg actgggtgga actccccgac
      781 ttcctgcgcc cgcacgccga ggcccgcgcc gcccagggca cgaccgatct cccgtacacc
      841 gtcgaacgcg ccctgcactt ctccaacggg ggcggggtgt acgccggttc gcaccgggag
      901 accggtgagg ccgtggtgct caaggagggc cggccgcacg ccgggctcgc cgccgacggg
      961 gccgacgcgg tcacccgcct gcagcgggag tacgcggccc tgcgcgccct cgaagggctg
     1021 gcgtgcgtcc cccgcgtgca cggactgcac accgtgggcg aacaccgctt cctggccatg
     1081 gagttcatcc ccggcacccc gctcaacacc gtcttcgccc gccgcttccc gctctccgcc
     1141 gccgagccgg ccgccgaagc cctcgccgag cacaccgcct gggccctgcg cacccaccag
     1201 ctcgtcacgg aggccgtcga ggcgctccac gcccggggca tcgccttcgg cgacctgcac
     1261 atgaacaaca tcatggtggc gccggaccag ctctccgtca ccctgctgga cttcgaggcc
     1321 gccaccccgg ccgccgagcg ccgcccgcag atcgtcgcca accccgcctt cgtcgccccg
     1381 ccccacctgc gcggcaccga ggtcgaccgg tacgccctgg cctgcctccg cctcgccctc
     1441 ttcgtcccgc tcaccaccct gctgcccctc gaccgcgaca aggcggccca cctcgccggc
     1501 ctcgccgccg accggtacgg catcgaccgc gccctcttcg acgaggcggt caccgaactc
     1561 gccggcccgg cacggccgga ggccgggccg tcacgcggcc ggccaccggt gtccgccacc
     1621 gactggcccg ccgcccgcga ctcgatggtg gccgccctgc tcgcctccgc cacccccggc
     1681 cgcgacgacc gctacttccc gggcgacatc gcccagttcg ccaccccggc cggcggacag
     1741 tcgtacggct acggcgccgc cggcgtcctg cacgccctcc acgccgtcgg cgcccgctgc
     1801 gaggaggccg aggaatggct gatccgcacc acccgccgcc ccgcctccgg caccccgacc
     1861 ggcttctacg acggcctcac cggcatcgcc tggaccctgg accgcctcgg ccaccgcgag
     1921 gaggccctgc gcctcgccca tctcgtcgcc gccgaacccc tcgacgcact cggccccggc
     1981 ctgcactccg gcgcccccgg cgtcgccctg gccctgcgcg acctggccga cgccgccgac
     2041 gaccccgccc tcggccaggc cgccgaccgc gccgaggccg ccgcactccg ccccgccgcc
     2101 cccggcggca aggccggact gctgcacggc ccggccggca ccgccctgct ctgcctgcgc
     2161 cgccacgccc gtaccggcga acccgccctg ctcgacaccg ccgccaccgc gctgcgcgag
     2221 gagctggggc gctgcgtgcc ggggccggac ggctcgctcg tcgtctccga ggcccggcgg
     2281 accatgccgt acctcggctc cgggagcgcg ggcatcgcga tggtcctcga cgactacctg
     2341 gcccaccgcc ccgaccccgc cttcgaggag gcccagaccg ccctcctgcg ggccaccggc
     2401 tccgccttct acatccagcc gggcctgttc cggggcgtcg ccggactcct cctccacctg
     2461 gcccgcacca ccacccccgg cgaccgggcc gcccgcaccg ccctcctgac ccgccagacc
     2521 gccctgctgg actggcacgc gctcacctac caagggcacc tcgcccaccc cggcgaacag
     2581 ctgacccgcc tgtcgatgga cctctccacc ggcacggccg gcgtcctgct cgccctggca
     2641 gcgacccacg gcgaacccgc cgcgcacctg cccttcctcc cgccgctccg gcggcccaca
     2701 gaccggccct gaacccaggg tcgcgcacca cccagcacca ccagcaccac tcgttttccc
     2761 aggtggcggt cgtccgaccg ctcgacacga aggagtacgt catggcgctt ctcgacctcc
     2821 aggcgatgga caccccgcag gaggaggcgg tgggcgacct cgccaccggc agccagatct
     2881 ccctgctcat ctgcgagtac agctcgctga gcgtcaccct ctgcaccccg tgacgcaggg
     2941 ctgaacccgg ctgtccgccg tgcgcccggc cccctgcggg ccgggcgcgt gcgacaaccc
     3001 ttggtcccgg gcgccccagc gcccgggacc tcccgcgttc cgcgcccgcc cggacagccc
     3061 ccgcccgctc gcccgcccga acggagcagc catgaccgcc gcccccgccg acgccgcccg
     3121 ggcccgcgcc actcccgccc cgccgcccgc cgaggggcgc ctgctgcggg aggcggtacg
     3181 ccggggcagg ggacccgcgg ccctcgtcct cgcggccacc gcgctcggcg ccgccgccgc
     3241 cgtcaccctg cccctcgccc tcggccgcgc cgtcgacctg ctcatcgccc gcgccgacgc
     3301 cgggtcctgg gtcctgctgt gcaccgcgct gatcgccacc gaggtggcca cggacgccct
     3361 cgtcgcccgc accggcggcc ggaccggcgc cgccaccacg gcctggctgc gccgccgcgc
     3421 gctcgccggc ttcctcgccg cgccccccgc cgcgactacc ggcaccggcc tgcccacccg
     3481 cctcaccgcc aacgccctcg acgccggaac cgcccccgtg gccgccgcca ccgctgccgc
     3541 cgccggcctc gcccccctcg gcggcctggc cgggctcttc ctcgtcgacc cctgggccgg
     3601 cgccgccttc gtctgcggcg tcccgctcct cctcctcatc ctgcgcgccc tgctccgcga
     3661 cggccgcgcc gccctcacca cgtaccagga ggaacagggc cgcatggccc gcctgctgac
     3721 cggcgccctg tccggcgccg ccaccatcgc cgccgccgga accgtccgcg ccgaggaacg
     3781 ccgcgtcctc gccccgctgg ccgggatgcg cgcggccggc gaacgcacct ggcgcgtgca
     3841 gggccgcgcc gccggcctct ccggcgcgct gatgccgctc ctggtcgccg ccgtcctcgc
     3901 cgtcggcggc gtacgcctcg tcgccggcca cctcaccccc ggcgacctcc tcgccctctc
     3961 ccgctacgcc gtcctcgccg ccggagccgg agccctggcc ggcgccgtca acggctgggt
     4021 acgcgccaag gccggcaccg cccgcgtcga gaccgtcacc gccctgccgc ccacccccca
     4081 cgggacgcgc gacctgcccc cgcacggcga cggcaccctc gccctgcacg gcgtccacgt
     4141 cacccgcgac ggcgtcccgc tcctcgactc cgtcaccctc accctccccg gcggcaccac
     4201 caccgccctc gtcggcccgt ccggctccgg caagtccctg ctggcggcgg tggccggccg
     4261 cctcaccgac cccgaccagg gcaccgtcct cctcgacgga accgacctcc gcaccctctc
     4321 cgccgacacc ctgcgccacg ccgtcgcgta cgccttcgaa cgcccggccc tctacggcgc
     4381 caccatcgcc gacgccgtcg cctgcggccc cctgcccgag cccgacctcc gccgagcctt
     4441 gcgccgcgcc gccgccgaca ccttcacgga ccgcctcccg cagggccccc gcacccccct
     4501 ccccgaagcc cccctctccg gcggcgaact ccaacgcctc ggcctggcac gggcgttctc
     4561 ccgccccacc cgcctcctga tcctggacga cgccacctcc agcctcgaca ccgtcaccgc
     4621 ccacctcgtc gcccgcgccc tcaccgacac ccccggcacc cgcctcacca tcacccaccg
     4681 cctcaccacc gccgcccagt ccgaccaggt cgtatggctc gacgggggcc ggatacgggg
     4741 gacggggccg cactccgttc tgtggcggga cccggcatac cgcgcggtct tcggggcggg
     4801 ggctgggggc gatgctggcg ctggggcgga caccgtcact gacacggagg cccgaaggcg
     4861 tagcgacgta cgtaccgacg tgactggcga tgtacgtacc gagctgccca ccgacatgcg
     4921 taccgacctc cataccggca tccgcaccga cccccgggtc gacaccggca ccggggccgc
     4981 cgagtgaccc gcccccgcca caccgacggc gcccccagcc ctctgctgcg ccccgccctc
     5041 accttcgccc gccggcgcaa gggtccgctg ggggcgctgg gggcctggtc gctcctcgaa
     5101 tcggcccgta ccttcctcac cggctacgcc gtcgcccgcg ccctggacga cggcttcctc
     5161 gccggagacg tccgcgcggg cctcctctgg ctgctcgccc tcgccgccgc agccctcgcc
     5221 gggggcttcg ccgacgcggg ggtcttccgc gcgctcggcg gcgtgatcga gcccctgcgc
     5281 gactccctgg tccgccgcgt cgtccgcgcc accctcaccc gggcggtcgc ctcacccacc
     5341 ccggccgaca cggcacgcgt ctcccgcctc accgcccaga cggagatcgc ccgcgacgcc
     5401 gccggcggcg tcctgctgac ggtacgttcc ttcctcttca cctcggccgg cgccttcacc
     5461 ggcctggcag cgctctcccc gaggctcctc ccgctcgtcc tgatccccct cgccgccggc
     5521 ctcgccctgt tcgccgccac cctccgcccc atggccgccc gccaacgcga cctcctcgac
     5581 gccgacgaac acctcgccgc cttcgccggc cgcaccgacc acgccgcccg cgacatcgcc
     5641 gccaccggcg cggcccccct cgtcaccgcc gaagcagccc ccctcatcac cgccgaggcc
     5701 accgccgcct ccgccctggc ccgctggtca gccgtacgcg tcaccgccct cggcctcgcc
     5761 gcccacctcc ccgtggccac cctcctcctc gccgccccca ccctcctctc caccggcctc
     5821 acccccggcg aactcctcgc cgccctcacc tacgtcacca ctgccctcct ccccgccgtc
     5881 aacgccctgc tgacggccct gggggcagcg ggatcacgac tgctggtcgt actgcaccga
     5941 ctgctggggg aggaagcgga cgcggcggac gtacgggagg agcaggcgca cgcgctgagg
     6001 gcggacgacg gaccacgggc accaggggcc tggtcgaagg ggaaggcgga cgacgaggtc
     6061 cccgccatcc ccgtaccctc acttcccccc gagcccgtac acgggcctga gccattccac
     6121 gcggaaccct caccccctgg accccgcccc acccgtgggc ctcgccccac ccgcccggca
     6181 ctccccgccg ccaccctgcg cggcctgacc ttcgcctacg gccccgacgc cgcccccgtc
     6241 ctcgaccacc tcgacctcac cgtcgaaccc ggcgaacacc tcctggtcgt aggcccgagc
     6301 ggcgcgggca agtccacctt gctggccctc ctcgccggca ccgcccaccc ccgccacggc
     6361 cagatccacc tcgcgggcca caccgcccgc cacgcccgca ccctcggcac ggccgcccgc
     6421 gtcctcgtcc cccaggagcc ctacatcttc gaggcccctc tccacgacaa cctcacctac
     6481 ctcgccccga acgccccggc ccctcgcatc acggaagcca tcgacacctt caccctggcc
     6541 cccctcgccg ctgaccccgc ccgccctctc cgcccggacc acctcacccc gtccgaacgc
     6601 cgccgcattg ctttggcccg ggcttggctg acacctacgc ccctgctcct cctggacgag
     6661 cccacggccc acctggacgc aggggcacgg gctgcgaccg agctggcctt cgcttcccac
     6721 ccggccacgg tcatcacagt gagccaccac tttccggcgc ctgaacctgg gcaacgcgtc
     6781 ctgctcttgg acggggcgac cccatacctg gggacccacg cctcgctcct tcgtgagtcg
     6841 gccttgtacg gggaactggc ggcggggctg ggggagcctt cggcgatggg gagccggggc
     6901 accgcgtcga cctaggcgtg ggcggggagc ggcggctgcc gggagggaac caaccccgca
     6961 cgcgcgggga gcagatcgtc acggtcctga acgccaccct cgacgaggga ccaaccccgc
     7021 acgcgcgggg agcagactgt gctcgcggtc gaggtggcga gcccgaaggg accaaccccg
     7081 cacgcgcggg gagcagcagc gcggcggcct catccacaac ccctcggcgg gaccaacccc
     7141 gcacgcgcgg ggagcagtgg gttgtgatca tcgtgcggcg gtgccaactg ggaccaaccc
     7201 cgcacgcgcg gggagcagtc tcgctgacct ggggtttcac tcagcccagt cactctctcc
     7261 cgcaagcttc aaagattccg gcaatgcggg tgaatgcctc atacccccta catggtgtcc
     7321 acccagcacc cgccccccat tgaacccgac agatctcccg cgaaccccgc ccttccagcc
     7381 actcacaccc cgaccccact cctcagcctc acccgaccca accccccacc ccacccgcca
     7441 agtcccaacc ccacccccgt accacnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     7501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     7561 nnnnnatcca cccggttcct cgcccccacc ttccgcgtag ccgaagcgat gtagttccgc
     7621 accgtcccgt gcgacaggca caacccccgg gcgatctccg ccaccgaatc cccctgcgcg
     7681 gccctgctca gcacccgcac ctcgcgtggc gagagcggca tgtccattgc tcggagcagg
     7741 ctcatcgcga gcccgtcgtc cacgtaccgc ccgcccccgg cggccagccg tatcgcggtg
     7801 gccaggtggt tggcgggccc gtcgcggtcg accaggccga gtgcgccggc cgcgtaggcg
     7861 agccggagca cgccagggtg ttccgcgccg gccagcacca ccagggccgc gcgcccccgg
     7921 ctcgctccgg cgaggccgat tccggcgcgc tctgcgcccg ccccggcgag gcccag
//
