LOCUS       BGC0000547             22620 bp    DNA     linear   BCT 03-JUN-2011
DEFINITION  Streptococcus salivarius strain JIM8780 salivaricin 9 lantibiotic
            gene locus, complete sequence.
ACCESSION   BGC0000547
VERSION     BGC0000547
KEYWORDS    .
SOURCE      Streptococcus salivarius
  ORGANISM  Streptococcus salivarius
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 13:49:22
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..22620
                     /db_xref="taxon:1304"
                     /mol_type="genomic DNA"
                     /organism="Streptococcus salivarius"
                     /strain="JIM8780"
     misc_feature    1..22620
                     /note="salivaricin 9 lantibiotic gene locus"
     subregion       1..22620
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000547"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..22620
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            619..5316
                     /gene="gtfD"
     CDS             619..5316
                     /EC_number="2.4.1.5"
                     /codon_start=1
                     /gene="gtfD"
                     /product="glucosyltransferase precursor"
                     /protein_id="ACX68639.1"
                     /transl_table=11
                     /translation="MENKVRFKLHKVKKNWVTIGVTTLSMVALAGGSLLAQGKVEADET
                     SAPNGDGLQQLSEDGTASLVMTTTVTEQASAQASVSAIETVGTNSQVVTSVVSQETTAQ
                     VQTSPVASREVAVSSQTQASAQETQTTEQASQGQTSTQVAGQTSTQSTPRVLTNAAPAI
                     ATRAADSTIRINANRNTNITITASGTTPNVTIITGPNTPKPNVTVTSPNGTRPNVTIVT
                     QPNQPNKPVQPSQPSQPNKPVQPSQPSLDYKPVASNLKTIDGKQYYVENGVVKKNTAIE
                     LDGRLYYFDETGAMVDQSKPLYRADAIPNNSIYAVYNQAYDTSSKSFEHLDNFLTADSW
                     YRPKQILKDGKNWTASTEKDYRPLLMTWWPDKVTQVNYLNYMSQQGFSDKAYTTDMMSY
                     DLAAAAETVQRGIEERIGREGNTTWLRQLMSDFIKTQPGWNSESEDNLLVGKDHLQGGA
                     LTFLNNSATSHANSDFRLMNRTPTNQTGTRKYHIDRSNGGYELLLANDIDNSNPAVQAE
                     QLNWLHYIMNIGSILGNDPSANFDGVRIDAVDNVDADLLQIASDYFKEKYRVADNEANA
                     IAHLSILEAWSYNDHQYNKDTKGAQLSIDNPLRETLLTTFLRKSNYRGSLERVITNSLN
                     NRSSEQKHTPRDANYIFVRAHDSEVQAVLANIISKQINPKTDGFTFTMDELKQAFEIYN
                     ADMRKADKKYTQYNIPAAYATMLTNKDSITRVYYGDLFTDDGQYMAEKSPYYNAINALL
                     RARIKYVAGGQDMKVTKLNGYEIMSSVRYGKGAEEANQLGTAETRNQGMLVLTTNRPDM
                     KLGANDRLVVNMGAAHKNQAYRPLLLSKSTGLATYLKDSDVPAGLVRYTDNQGNLTFTA
                     DDIAGHSTVEVSGYLAVWVPVGASENQDARTKASKTKKGEQVFESSAALDSQVIYEGFS
                     NFQDFVKIPSQYTNRVIAQNAKRFKEWGITSFEFAPQYVSSQDGTFLDSIIENGYAFED
                     RYDIAMSKNNKYGSLKDLMDALRALHAEGISAIADWVPDQIYNLPGKEVVTASRTNSYG
                     TPRPNAEIYNSLYAAKTRTFGNDFQGKYGGAFLDELKAKYPAIFERVQISNGRKLTTNE
                     KITQWSAKYFNGSNIQGTGARYVLQDNATNQYFNLKAGQTFLPKQMTEITATGFRRVGD
                     KVQYLSTSGYLAKNTFIQIGANQWYYFDKNGNMVTGEQVIDGKKYFFLDNGLQLRHVLR
                     QGSDGHVYYYDPKGVQAFNGFYDFAGPRQDVRYFDGNGQMYRGLHDMYGTTFYFDEKTG
                     IQAKDKFIRFADGRTRYFIPDTGNLAVNRFAQNPENKAWYFLDSNGYAVTGLQTINGKQ
                     YYFDNEGRQVKGHFVTINNQRYFLDGDSGEIARSRFVTENNKWYYVDGNGKLVKGAQVI
                     NGNHYYFNNDYSQVKGAWANGRYYDGDSGQAVTNRFVQVGANQWAYLNQNGQKVVGLQH
                     INGKLYYFEGNGVQAKGKLLTYRGKKYYFDANSGEAVTNRFIQISRGVWYYFNASGQAV
                     TGEQVINGQHLYFDASGRQVKGRYVWVKGQRRYYDANTGAWVRKR"
     protocluster    1811..22620
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[11810:14594]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      11811..14594
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1811..22620
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     mobile_element  6119..7047
                     /mobile_element_type="insertion sequence:IS116/IS110/IS902
                     family"
     gene            6365..6586
                     /locus_tag="salivB0665"
     misc_feature    6365..6586
                     /locus_tag="salivB0665"
                     /note="nonfunctional transposase due to mutation"
     gene            6606..7157
                     /locus_tag="salivB0666"
     misc_feature    6606..7157
                     /locus_tag="salivB0666"
                     /note="nonfunctional transposase due to mutation"
     mobile_element  7180..8290
                     /mobile_element_type="insertion sequence:IS1193-like"
     gene            7201..8019
                     /locus_tag="salivB0667"
     CDS             7201..8019
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1206:transposase
                     (Score: 302.5; E-value: 7.8e-92)"
                     /gene_kind="other"
                     /locus_tag="salivB0667"
                     /product="transposase"
                     /protein_id="ACX68640.1"
                     /transl_table=11
                     /translation="MRLIKNTTELIGIKDQNIKISLVFETNTHLEIQAKLDYPAPSCPH
                     CHGKMIKYDFQKPSKIPLLEQAGTPTLLRLKKRRFQCKNCRRVTVAETSIVEKNCQISN
                     LVRQKVAQLLTQKMSLTDIARRLRVSTSTVYRKLDQFTFKEHYDKLPAVMSWDEFGFKK
                     GELAFVAQNYETNQLITILDNRRQTTIRNYFLKYPLKARQKVQFITMDMSGAYIPLAKR
                     LFPNAKIVLDRFHIIQHLGRAFLKTRIMIMNQFDKKSLPYRALKNHWRLF"
     CDS             complement(8465..8653)
                     /gene="allorf_08465_08653"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_08465_08653"
                     /protein_id="allorf_08465_08653"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MSPNSPITLVAVVSAIPGIERRISYSGRGLANSTNCSKTCSRRFV
                     NLISSCALYWLFVNCSG"
     CDS_motif       complement(8609..8653)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MSPNSPITLVAVVSA"
                     /locus_tag="allorf_08465_08653_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(8465..8608)
                     /prepeptide="core"
                     /locus_tag="allorf_08465_08653_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.90"
                     /molecular_weight="5021.7"
                     /monoisotopic_mass="5018.6"
                     /core_sequence="IPGIERRISYSGRGLANSTNCSKTCSRRFVNLISSCALYWLFV
                     NCSG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSPNSPITLVAVVSA"
                     /leader_location="[8608:8653](-)"
                     /alternative_weights="5039.8"
                     /alternative_weights="5057.8"
                     /alternative_weights="5075.8"
                     /alternative_weights="5093.8"
                     /alternative_weights="5111.8"
                     /alternative_weights="5129.9"
     CDS             complement(8730..8867)
                     /gene="allorf_08730_08867"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_08730_08867"
                     /protein_id="allorf_08730_08867"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MSFAFLIEICDMARIGMASCSDIVNTFVQNFSCIRIPTLSDMLLT
                     "
     CDS_motif       complement(8817..8867)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MSFAFLIEICDMARIGM"
                     /locus_tag="allorf_08730_08867_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(8730..8816)
                     /prepeptide="core"
                     /locus_tag="allorf_08730_08867_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.30"
                     /molecular_weight="2963.4"
                     /monoisotopic_mass="2961.5"
                     /core_sequence="ASCSDIVNTFVQNFSCIRIPTLSDMLLT"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSFAFLIEICDMARIGM"
                     /leader_location="[8816:8867](-)"
                     /alternative_weights="2981.4"
                     /alternative_weights="2999.5"
                     /alternative_weights="3017.5"
                     /alternative_weights="3035.5"
                     /alternative_weights="3053.5"
     gene            complement(9198..10565)
                     /gene="sivK"
     CDS             complement(9198..10565)
                     /EC_number="2.7.13.3"
                     /codon_start=1
                     /gene="sivK"
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 160.7; E-value: 1.2e-48)"
                     /gene_kind="regulatory"
                     /note="sensor protein"
                     /product="SivK"
                     /protein_id="ACX68641.1"
                     /transl_table=11
                     /translation="MFKLRVVTQFIRRFIVSVIVMSIINIFIIVFFVFSQANQTNVMDT
                     VSSLVKQLDISSNSAKLSNLGKKLANSKEVWIMVLDSDSGKEIYEYKKPSEVPTQYSLT
                     DVAKFTRYYLNDYPVFVQIINNKILVFGFSKDNVFKFPFNYYEKSDLHNLFILAFFLLG
                     INCLYLLIIYTYSTRVVQRKITPLVSAIQKLPEGLSGSVATQDELKQLTEAINIADNKL
                     KEGELFKENWISGIAHDIKTPLSVIISNASLIKSDTADKNQLRRLRSILNESYYIQNTI
                     NDLNIFARLTNNQFSLKLESVKIISFFRKIIIQIINQEVWENSNFAFEFDDKLQNSTIS
                     IEKNLISRVLHNIIYNSILHNPEGCNVNIRLHRDKEFLIITIEDNGIGITNDKLLSIHN
                     SNKIIEEFDISGIRRHGMGLKISKQIIEVHEGSFKVESKEKQFFRVIITLPLEGEV"
     gene            complement(10577..11275)
                     /gene="sivR"
     CDS             complement(10577..11275)
                     /codon_start=1
                     /gene="sivR"
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 166.4; E-value: 1.2e-50)"
                     /gene_kind="regulatory"
                     /note="response regulator"
                     /product="SivR"
                     /protein_id="ACX68642.1"
                     /transl_table=11
                     /translation="MDIEAPFLARKILVVDDDVALNHSIREILSVSGFSKIYSAYSISE
                     GIESFVKNSIDLIILDVMLPDGEGYLLSKYVRKESDIPILFLTAKNEPEDEIQGLQSGG
                     DDFITKPFLPKILIYRTISLLRRSYKEDSNTIKLDHCIINLGNAIVEKDNEKLSLTPIE
                     IQIIRKLYDNKNYIVSTEAICDTVWGIDSFGYEKSLMVHIRNIREKIELNPSKPQYLVT
                     VKGLGYKLMV"
     gene            11473..11643
                     /gene="sivA"
     CDS             11473..11643
                     /codon_start=1
                     /gene="sivA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /product="bacteriocine"
                     /protein_id="ACX68643.1"
                     /sec_met_domain="L_biotic_A (E-value: 5.1e-26, bitscore:
                     80.0, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 6.8e-08, bitscore:
                     22.1, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSTNNQSISEIAAVNSLQEVSMEELDQIIGAGNGVVLTLTHECN
                     LATWTKKLKCC"
     CDS_motif       11473..11568
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence:
                     MKSTNNQSISEIAAVNSLQEVSMEELDQIIGA"
                     /locus_tag="sivA_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       11569..11643
                     /prepeptide="core"
                     /locus_tag="sivA_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="5.20"
                     /molecular_weight="2561.0"
                     /monoisotopic_mass="2559.3"
                     /core_sequence="GNGVVLTLTHECNLATWTKKLKCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKSTNNQSISEIAAVNSLQEVSMEELDQIIGA"
                     /leader_location="[11472:11568](+)"
                     /alternative_weights="2579.1"
     gene            11811..14594
                     /gene="sivM"
     CDS             11811..14594
                     /codon_start=1
                     /gene="sivM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     711.7; E-value: 2.5e-215)"
                     /gene_kind="biosynthetic"
                     /note="modification enzyme"
                     /product="SivM"
                     /protein_id="ACX68644.1"
                     /sec_met_domain="DUF4135 (E-value: 3.7e-73, bitscore:
                     236.3, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 6.5e-61, bitscore:
                     195.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYNQLYEQFDKFPLFIIKQKFNYKSLENSNNRKVLEKIILDYYR
                     PTLIYLINEKRVNGELKGNTPEERYDYFNQELCGSGKIFGEIEIRFPEINDRIELIVKK
                     YLDLHERVKSTFVKDFRFLCDNKFLHSDKLKPDLDKLEIEVTGDIHDGAGVCIISYNNQ
                     KVVYKRKSSIANRFLRKIDLMVSEFFNEEIRFIPNILDRDGYFWEQYINNQKLKNANEA
                     REYYTNMGFLLFYAYIFNISDLHFENILSSGKSPILVDVETLFSTSPFEIIADNFATKE
                     ITQRSRSSVLSSGLLPISEAEKIFGGDLSGILGGTLVNEFKTVINNYRDDIRIEKVVQA
                     TKYQSHLPFFEYLGQKEYLVATNYVNDIIAGFKLVSDFFLNHKEEILEVYQQYSDLKTR
                     ILFRNTHEYDVVSQLLISPIYSQKQDLLFKKMSEKLSHYDSSKLCESEVRQLLSMDIPS
                     FYIEANSTIVTDGYSDVWKIRKTPLYSVTEKLNKLTEDKISEQVELIRFSLQADRDSES
                     TEMQELYKKYDDFRNEENIMINALNNLVDEILAKMYLDPDDESINWMTLKVNDHNNFEL
                     VPMDNSIYDGISGVALSLIECYSLLDKNRKRKVYRCLCYLFKTLVNVYSNILDMTYYVG
                     RLGILSTLVRISQITKQEIPQKILNSKVSLINQALQNTPADFLTGFSSSILACEEDEYS
                     EEFLRTMINRFKELKQYDSNHNYIYWGKEESNNVSLAHGNAGIEISLLYLAGKLKSRDA
                     KEMYEDAKKFDDKQRLDQGWIDKRFSDSNAQWCHGSTGVLISRLAQLKLNQEFKILSIQ
                     EESLLVEDIQHAIKQIILIGFDMNNFTLCHGVGGNLLALTYYNNLYGGENSSELEEIIN
                     SEYRKMLSFGIKYGWMCSLNTNFDSYGLMTGLAGIIYSVSKYLKSDSSLEILTPVF"
     gene            14611..16689
                     /gene="sivT"
     CDS             14611..16689
                     /EC_number="3.4.22.-"
                     /codon_start=1
                     /gene="sivT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 126.4; E-value:
                     2.5e-38)"
                     /gene_kind="transport"
                     /product="putative ABC transporter"
                     /protein_id="ACX68645.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 8.7e-39, bitscore:
                     122.0, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVILQNNEEDCLLACYTMLLNDLGYKVPLYEVYERDSLPADGLS
                     VSYLLTLNKNFNVDIKAYKANFDEVISLIRVRGNNRVIVHWNNDHFVVLEKITKNYIKI
                     VDPAIGRIKFSKDEFLEHYSGTVITVLPTVDFHRQKVRTLFFKYFKNTLEVRAIFSFLI
                     SLLLIEISVLLFSIVIRNMVAGNLKFIASLLLLFTIILLQIVGYYIKNFALEKYNSNFD
                     KSYTTILFKRLLNKPLLYFRNHTNGSISEKISFRTTLRDSVATKLIPSIVSLVSSFVIF
                     IYLVIISFRLTIILVSMIVLYSLISSVLYYKQNEYNQSYLQYLIDFNSDFQSDLEDIDY
                     IKVMRNERETEDRWTKNNDRLTSKYSQILKVENFVQLFGSIFSYFSLSIVILAVIYNNK
                     FFNVSIADLVLYQTSISLLISSIEQVKTSIFEIARLAIYAEKQGDILKENLPINVNFDL
                     DSNYIIQTENLNFGYGNESLYKPVNLKINQGEKIAIIGKSGSGKSTLLLLLTGMLRHSG
                     KITYNSEHLENYMGVILQNMTLKKGSVLENFEYDSPDLTKLSKILVDTTADEVIAKLPN
                     KLQSKLLKQGKNLSGGQIQKLLIAKSLLKGEKMIFWDEAFSNLDEMSKDKIYENVLLGS
                     FYKDKTMLIVSHHLDIVNYVDSVIFINDETGEVIKSTHEDLQKNNLDYKRFICNKGV"
     gene            16723..17652
                     /gene="sivF"
     CDS             16723..17652
                     /EC_number="3.6.3.-"
                     /codon_start=1
                     /gene="sivF"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 173.8; E-value:
                     7.7e-53)"
                     /gene_kind="transport"
                     /note="ABC transporter"
                     /product="transport ATP-binding protein"
                     /protein_id="ACX68646.1"
                     /transl_table=11
                     /translation="MKGMDYTMTEVIKLKKLKKNFKGVSSVDLEGLTVRKGEIYGFLGP
                     NGAGKTTTMKMILSLIEPTSGSIEIMNTPINRSNDYLKYIGSMIEEPSYYPNLTGYENL
                     LVFQKMLGFKEENILKTLELVGLSEEKNRKKLVKAYSLGMKQRLALAFALVKEPQILLL
                     DEPTNGLDPSGIHEIRELIIRLAKDKGLTVFISSHILSEIEQIADRVGIINHGRLVYEG
                     EIEKINTNNWVEIEGKFDIEKLKNLFGNHFSNRKVEYDAKLVKIWNTNNEQIANIVRSL
                     FELDFPIFRVEHKKENLEDIFLELTKEL"
     gene            17654..18409
                     /gene="sivE"
     CDS             17654..18409
                     /codon_start=1
                     /gene="sivE"
                     /note="possibly involved in Sal9 immunity"
                     /product="putative transporter"
                     /protein_id="ACX68647.1"
                     /transl_table=11
                     /translation="MVNALQIELLKSRRTKSFIITIFLMFIGFLWNTVSTGSEINSVNY
                     DGASVLFNNQTMNSLFLPIAISIFTSRIVSNELEGQTFKLQESNGRTLIQIFYSKLILS
                     TVFFLILAILGTVATNVFAMVNGVSVPLTITIIQILGQLLSSFSLICIYLTFAMFTDKQ
                     GLLLSSGFLGGFIGLILASKSTIFWTFAIPWVGSAYLSPYKFTLINNSNYLYKFDQSIY
                     FRFLIYLIYCLLLYLLVRSIFLKKERQRK"
     gene            18406..19140
                     /gene="sivG"
     CDS             18406..19140
                     /codon_start=1
                     /gene="sivG"
                     /note="trans-membrane domain bacteriocin immunity protein"
                     /product="putative transporter"
                     /protein_id="ACX68648.1"
                     /transl_table=11
                     /translation="MRHYTSAEWKKLNKIQILIVGVVFVALSSFIGLGTYFANHSVLID
                     GTQDKVMWGQLTFYYTQILYSPMLAIFIAISLTQEFERKNLEMLCSNAISIKKLLISKL
                     LTVTVLVIPIQLLILIVYIIALEVADVELSSFVLLTLKWTLLSILSSLSILCIQAFVYA
                     KTRSFGQSIGISAIGAMGGFVLLFLNENLNKFYPYSQPMVALRSRALDDFSLLELTIFV
                     FVNLLFSVIFYRLTCYELEKRG"
     gene            20470..22455
                     /locus_tag="salivB0678"
     CDS             20470..22455
                     /codon_start=1
                     /locus_tag="salivB0678"
                     /note="putative glucosyltransferase precursor"
                     /product="GtfX"
                     /protein_id="ACX68649.1"
                     /transl_table=11
                     /translation="MEKKVGFKLHKVKKNWVTIGVSTLSMVALAGGALLADQSAQADEV
                     SLPNGDGFEQTDAGIESSASLINESYSPTLTEDAGHLSAVSSNYGSQTNSGYESSSSAS
                     TGGSSQTVVGGRSGQVSSSQSSQVVGTQNSNSSQTGSAYQSSSSSASVSASASSSSSSS
                     SSAWYSYSSSSSWSSSSSASGFATITTSSSDSNGIHWNGGRNTTITITASGTTPNVTIV
                     SNSNKLFPNVTVGQSNGSNTNVTIISQGNQQNNSGYQIITGETKPSVDSNNAKSSFVRV
                     GENQWYYYDQYGQKVKGEKVIDGKAYYFLENGLQARDSLVKGSDGYTYYYDKNGVKAIN
                     GFYDFAGYRKDVRYFDCYGHMATGLLEMCGTTFYFDTQTGIQAKDKFIRFSDGRIRYFI
                     PNTGNMAVNTFVQNKENQAWYYLDEHGYAVTGKRIINGKEYCFDSEGRQIKGQMMQQGN
                     KHYYISAQTGEMAVSRFIFENNNWYYADAFGCLVQGAKVIDGKLYYFNKDHSQLKGGWA
                     EGRYYDAVTGQAVINQFIQIAANQWAYLNQDGHKVTGLQNINNKVYYFGSNGAQVKGKL
                     LTVQGKKCYFDAHTGEQVVNRFVEAGRGCWYYFNAAGQAVTGKQVINGKQLYFDGSGRQ
                     VKGRYVYVGGKRLFCDAKTGELRQRR"
ORIGIN
        1 ctacaataaa ccgtatttag gcattaggta actaatatca atcttttaga taatccccca
       61 agtgtccttt aaagcaaaat taaaacgctt acatgttcac ctagccttat tataatcctt
      121 ttttaagaat aaacaacaga aactaacgga attatcaaaa atgttaaaga actgacataa
      181 aagattctat atttagtttc gttagtcaaa taagaattca cctgtgtaaa tcatttatat
      241 ttttaatttt tgttcctcat agacaggacc tggtcttagt cagatgaaaa actagagtct
      301 ttctatctaa aattttcttt tcagaattgt ctttttaggg tctacctctc tcatagtttt
      361 gctatctctt aagcttattt gaagcttgct ttaatgttca aaagccttta aggataagtg
      421 tttgaaggtg tttgagaatc aaaaactttc tatttaagac tttacatgaa gtgtaaggtc
      481 tcattttcgc taatcaaagt taatataact gagcgcatgg cagagattta tgaaaagaag
      541 atgacttttt cctatttgta atttgtctga atatatcata gagtagagtc aacaacagaa
      601 aaaggatgat tgatatagat ggaaaataag gtacgtttta aactacacaa ggttaagaaa
      661 aactgggtaa ctatcggggt gaccactctc tcaatggttg ccttggcagg tggaagcctc
      721 ctagctcaag gaaaagtaga ggccgatgag acgagcgcac ctaacggtga cggcttgcag
      781 caactgagtg aggatgggac tgccagtcta gtgatgacaa caactgttac tgagcaagct
      841 agtgcgcaag caagtgtgtc agcaatagaa acagttggaa caaactcaca ggtggtgaca
      901 agtgtggtca gccaagagac aactgctcaa gtacaaacta gtccagttgc cagtcgggaa
      961 gtggcagttt cttcgcaaac tcaagctagt gcccaagaga cacagactac ggaacaggcc
     1021 tcacaaggtc agacatcaac tcaagtagct gggcaaacaa gtactcagtc cactcctaga
     1081 gtcttgacca atgctgcacc agcaatcgcc acacgcgctg ctgacagcac tattcgtatc
     1141 aatgccaacc gcaacactaa catcacgatt acggccagcg gtacgacacc aaatgtaacc
     1201 attatcacag gaccaaacac tcctaagcca aacgtgacgg tgacaagtcc aaatggcaca
     1261 agaccaaatg tgaccattgt aacgcagcca aatcaaccaa acaaacctgt tcaaccgagt
     1321 caaccgtctc aacctaataa gccagtccaa ccaagtcagc caagtcttga ctataaacca
     1381 gtagcttcca acttgaagac tattgatggc aagcagtatt atgttgaaaa tggcgttgtg
     1441 aaaaagaaca cagcgattga acttgatggt cgtctttatt atttcgatga gactggggct
     1501 atggtggatc aaagtaaacc tttgtatcgt gccgatgcca ttccaaataa ctctatctat
     1561 gcggtttata accaggccta cgacacgtca agcaagagtt ttgaacactt ggacaatttc
     1621 ttgacggctg atagctggta tcgtccaaaa cagatcttga aggacgggaa aaattggaca
     1681 gcttcaactg agaaagatta tcgtcccctt ttgatgactt ggtggccaga caaggtgaca
     1741 caagtcaact acctcaacta tatgagtcaa caaggcttta gtgataaggc ctatacgact
     1801 gacatgatga gctatgactt ggcagctgct gccgaaacgg tgcaacgagg aattgaggaa
     1861 cgtattggtc gcgagggcaa taccacttgg cttcgccagt tgatgtcaga tttcatcaaa
     1921 acacagcctg gctggaactc tgagagtgag gacaatctct tagttggtaa agaccacttg
     1981 caaggaggcg cactgacttt cctcaataat agtgcgacaa gtcatgccaa ttcagacttc
     2041 cgcctcatga accgcacacc gactaaccaa acggggacac gcaaatacca tattgaccgt
     2101 tcaaatggtg gttacgagtt gctcttggca aacgatatcg acaactctaa cccagctgtt
     2161 caggctgaac aactaaactg gctccactac atcatgaata ttggttctat ccttggcaat
     2221 gatccaagtg ccaactttga cggtgttcgt atcgatgcgg tggacaatgt ggatgcggac
     2281 ctcttgcaaa ttgcttctga ctacttcaag gaaaaatacc gtgtggctga caatgaagcc
     2341 aacgccattg ctcacttgtc aatccttgaa gcttggtcct acaatgacca ccaatacaac
     2401 aaggatacca agggtgctca gttgtccatt gacaatccac tacgtgaaac gcttttgaca
     2461 actttcttgc gtaagagcaa ttaccgtggc agcttggagc gcgtgattac taactctctt
     2521 aacaaccgtt caagtgagca gaaacacacg ccacgtgatg ccaattatat tttcgtgcga
     2581 gcccatgata gtgaagtgca agctgttttg gccaatatca tcagcaagca gattaatcca
     2641 aaaacagatg gtttcacctt cactatggat gagctcaaac aggcttttga aatctacaat
     2701 gcggacatgc gcaaggctga taaaaagtac acccagtaca atatcccagc tgcctatgcc
     2761 acaatgttga ccaacaagga tagtatcact cgtgtttact acggagatct ctttaccgac
     2821 gatggccaat acatggctga aaaatcacca tactataatg ccatcaatgc cctgcttcgt
     2881 gctcgcatta aatatgtagc aggtggtcaa gacatgaagg ttactaagct taatggctat
     2941 gaaatcatgt catctgtacg ttatggtaag ggggcagaag aagccaacca acttggtact
     3001 gccgagacac gcaaccaagg aatgctcgtc cttacaacca accgtccaga tatgaagttg
     3061 ggggcaaatg accgtttggt ggtcaatatg ggagctgccc acaaaaatca ggcctaccgt
     3121 ccattgcttc tcagcaaatc gacaggtctt gcgacctacc tcaaggattc tgatgtgcca
     3181 gctggattgg ttcgctatac ggataatcaa gggaacttga ccttcacggc agacgatatt
     3241 gctggtcatt caaccgttga agtttcaggt tatttggcag tttgggtgcc agtaggtgct
     3301 tctgaaaacc aagatgcccg taccaaggct tcgaagacta agaagggtga gcaggtcttt
     3361 gaatcatcag cagctcttga ctcacaagtc atttacgaag gcttctcaaa cttccaagat
     3421 ttcgttaaga taccaagtca gtacaccaac cgtgttattg ctcaaaatgc caaacgcttc
     3481 aaagagtggg gaatcacttc ctttgaattt gcgccacaat acgtgtctag ccaagacggc
     3541 actttcttgg attctatcat tgaaaatggc tatgccttcg aggaccgtta cgatattgcc
     3601 atgagcaaga acaacaaata cggttcactc aaagacctca tggatgctct tcgtgccctt
     3661 cacgctgaag gtatctcagc cattgctgac tgggttccag atcaaattta caatctccct
     3721 ggaaaagaag tggtaacagc ttcacgtacc aacagctacg gcacaccacg tccaaatgct
     3781 gaaatctaca atagtctcta tgcagctaaa acacgtacct ttggaaatga cttccaaggc
     3841 aagtacggag gtgccttcct tgatgaattg aaggcaaaat acccagctat ctttgagcgc
     3901 gtgcagattt caaacggccg taaattgact acaaatgaga aaatcacgca atggtcagcc
     3961 aagtatttca atggaagcaa tatccaaggt acaggggctc gctatgtctt gcaagataac
     4021 gcaacaaacc aatacttcaa cctgaaagca ggtcaaacct tccttcctaa acaaatgaca
     4081 gaaatcacag caactggttt ccgtagggtg ggagataagg tccaatacct ctcaacgagt
     4141 ggctaccttg ccaagaatac cttcattcaa atcggtgcca accagtggta ttactttgat
     4201 aagaacggta acatggtcac aggtgaacag gtcattgatg gcaagaaata cttcttccta
     4261 gacaatgggc ttcagctacg tcatgttctt cgccaaggca gtgatggtca cgtctattac
     4321 tacgatccta aaggggttca ggcctttaac ggattctacg actttgcagg tcctcgccaa
     4381 gatgttcgct attttgatgg taacggtcaa atgtatcgtg gtctccacga catgtatggc
     4441 acaaccttct atttcgatga aaagactggt attcaagcta aagacaagtt catccgcttt
     4501 gcggacggtc gcacacgtta cttcattcca gatacaggaa atctcgcagt taaccgtttt
     4561 gcgcaaaatc ctgaaaacaa ggcttggtat ttcctcgata gcaacggtta tgccgtgaca
     4621 ggtcttcaaa cgattaacgg taagcagtat tactttgaca atgaaggacg tcaggttaag
     4681 ggacactttg tcactatcaa taaccaacgt tacttccttg atggcgatag cggtgaaatt
     4741 gctcgttcac gctttgtgac ggaaaacaac aagtggtact atgtcgatgg caatggtaag
     4801 ctggttaaag gcgctcaagt tatcaatggt aatcactact atttcaacaa tgattatagc
     4861 caagtcaagg gtgcctgggc taacggccgt tactatgatg gtgactcagg tcaggccgta
     4921 accaaccgct ttgtccaagt cggtgccaac caatgggctt acctcaacca aaatggtcaa
     4981 aaggtagtcg gtctccagca tatcaatggt aaactttact actttgaagg caacggtgtc
     5041 caagctaaag ggaaacttct gacttacaga ggtaagaaat actactttga tgccaatagt
     5101 ggtgaagccg taaccaatcg ctttatccaa atttctcgtg gtgtttggta ttactttaac
     5161 gcctcaggcc aagccgtaac aggtgagcaa gtcatcaacg gtcaacacct ctactttgac
     5221 gcttctggcc gtcaggtcaa aggccgttac gtctgggtta aaggccaacg ccgttactat
     5281 gacgccaata ctggagcttg ggtcagaaaa cgataagaga agaagtttat cctaattagg
     5341 aacctaaaaa cttatgagcg tatgaaacat taatgtttca tgcgcttttc tcatactcaa
     5401 atcctaataa ttttgttgct ctcatattca aaagaaagcg ctctaaccat gttataatgg
     5461 aaattatagt ttttattcag aatattttgt aaacggtttt cagttttcgt tgatgctgat
     5521 ggggtcttga atgaaaatgt tgtatctgta atatataaag ttgttagatt tagaagaaag
     5581 tgagggctga gcctgtgaag aatattttag ggggaagtta tgacaagtaa gaaagaagat
     5641 ttgctaacgc tttgggtaat gttcttgata ggtcttgtag ctattttcgg tggtgcgatt
     5701 tatatgaacc ataaaaaaga acaaggtttg tacaaacatg gtttcaggct tttggaagaa
     5761 cagattggaa gttatgttat tgaacattat tcaggggttg aaaaggttga gttttcacca
     5821 atttttatta atactgatgg gatgtttacc gcaaaagttg tgcctgtaat ctatgatttg
     5881 cacggaaata aagcctacct tggtcgacca gtaaaaggtg ggagagattg atataaagat
     5941 tacggattac gggatggtct tgagtgggat agcggtactg ggataggcga tgaaatcatt
     6001 tatttggaag attttgatca agataaacaa tacgatgttt caaaatatag agaactccca
     6061 tactttgcca agttgaaatc tgatgaaact atggatgcaa atatcagtga aatcgtagaa
     6121 aacatactaa gattagtagt gaagaaattt ccgacgggag agagtactca ctactttttc
     6181 tttgtgttaa agtagaggtg tcttgttaag tcgtggcttc ttttggcgct agacgtcgta
     6241 caaaaaactg acaagacacc tgttttagat gaaattttat caaagtatgt tggacgttag
     6301 acgccgagta ttgaaaatga aatcactaaa ataaggaatc attcaagaca aagaggtaaa
     6361 cataatgcgg acagttttgg gaattgatgt gagtaaagca agctcagaaa tcgctattct
     6421 tgtaaatagt gaaagggttc attgctatac tatgcctaat gacattatcg gattttctca
     6481 tctactgaag gatctaaaga ccgtgagcac cccccgaaat tattttcgaa gctactggtg
     6541 tctactctcg acgacttcag gcttttctag aagaaaacag ctatgactat acacgtctta
     6601 atcctttgga agctaagaag caacttgatg gattacgagt tcggaaaacc gataagattg
     6661 atgcagagaa actagcttcg tcacaattcg ttttaagccg taagccaact tacgttcaag
     6721 aagaagtcta tcaaaacttg catgatctta gccgattcta ccaaaatctg acagaggata
     6781 tcgtaaggac gaagaatagg ctgcacaaag ttcttcaagt cgccttccca gaaatcgaga
     6841 ttctactatt tattcctaca ggtgagcaat attggaatct cgtgtccatc ttcccaacaa
     6901 agcattgggt gttggaatta tcagaagttg agttgaaaga gactattcgc aactcaacct
     6961 ctaaacgcat ttcagagaac agagtaggta acttggctga gaagttagtt ggactggcaa
     7021 agcaatcgta ttctgccact tcaaaaacct ctcctatgat agaagaggtt aagtataatg
     7081 gctctataat ttctgtagtg ggtaaaacca ctgtagagat tatagagctt tttgagtgta
     7141 cacaaaaagt cccataagaa ctataatgaa aagcgaccaa accatcatta ggaagaactt
     7201 atgagactta ttaagaatac cacagaatta atcggaatta aagaccaaaa catcaagatt
     7261 tcacttgttt ttgaaactaa cactcattta gagattcaag caaaacttga ttatcctgca
     7321 ccatcatgtc ctcattgcca tggaaaaatg atcaagtacg actttcaaaa gccttctaaa
     7381 atccctcttc tcgagcaagc gggaactcca actctactac gtctgaagaa gcgtcgtttc
     7441 cagtgtaaaa attgtaggag agtcacggta gctgagacat caatcgttga gaaaaactgc
     7501 caaatctcca atctagtccg acaaaaggtt gcacaactct tgactcagaa gatgtcatta
     7561 acggatattg ccagaagact tcgtgtgtcg acatccactg tctatcgtaa gctcgaccag
     7621 tttactttca aggaacatta tgacaaactt ccagctgtta tgtcctggga tgagtttgga
     7681 ttcaagaaag gggaattggc ttttgtagcg cagaattatg agaccaacca actcataacc
     7741 atccttgata atcgccgcca aaccactata cgaaactact ttttaaagta tccattaaaa
     7801 gctcgccaaa aggtacagtt tatcacgatg gatatgtccg gagcttatat tccacttgcc
     7861 aaaagacttt ttccaaacgc taaaatcgtt cttgatcgtt tccacattat ccagcacctt
     7921 ggtcgtgcct ttttaaagac aagaattatg attatgaacc aattcgataa gaagtcacta
     7981 ccctatcgag ccttgaaaaa tcattggcga ctcttctaaa aggacagccg taaactatct
     8041 ctcaactctt tttattcaaa gacattccgc caaaccttaa gtccacatga agttgttggg
     8101 aaaacactag acttttcaga agagcttacc gactactata ctctttttca gcttttgctt
     8161 tttcactttc aggagaaaag agcagatgag ttttttgaac tcattcaaga aaacttaaac
     8221 gtcgtcaatc attattttca aactgtcttt aggacttttc ttagacacaa gcaatacatc
     8281 aaaaacgcac tagaaacgga ctattcaaat gcaaaactcg aagcgactaa taagttgatc
     8341 aaagacatca aacggttggg gttcggcttt agaaacttca tcaactttaa gaagcgtgtc
     8401 tttatcacac tgaacataca taaaaagagg acctatccgg tcctctctag atgttagctt
     8461 ttcgtcaccc actacagttg acaaagagcc agtataatgc acaggaactt ataaggttga
     8521 caaaccgtcg ggaacaagtt ttagaacagt tggtagagtt agctaaacct ctacctgaat
     8581 atgagattct tctctctatt cctggtatcg cagaaacaac ggctacaagc gttattggcg
     8641 aattaggaga cattcgtcgc tttaagtctg ctaatcaaat caacgctttt atcggtattg
     8701 atctcaacca ctatgaatag ggagatttcc taggtcaaga gcatatcact aagcgtggga
     8761 atccttatgc aagaaaaatt ctgtacaaat gtattcacaa tatcgctgca gctagccata
     8821 ccaatccttg ccatatcgca gatttctatg agaaacgcaa aagacaatcg cagacaactt
     8881 caaccaagcc acacacgatt gcctctatac atcgccttat taggacaata tattatctta
     8941 aaatgcataa taaactttac gactatactt tagcccaaag tcattaaagt catctatacc
     9001 ctataattct aacaccttgt ttcaaaaaat tccagataag gtgtcgtttt tatatgctca
     9061 aatgtcagaa aaaacggctt aaactattcc taaaaaaatt cccttcatgc actttcagaa
     9121 ataatgttga gtcagaaacc gtattatact tgacaaatgg tagaaaatag aactctatct
     9181 gctatgacta tcaataatta tacttcacct tctaaaggta aagtaattat aactctaaag
     9241 aattgtttct ctttactttc cactttaaag cttccctcat gaacttcgat aatttgtttt
     9301 gagattttta atcccatacc gtgtcgtcta attcctgaga tgtcaaattc ttcaatgatt
     9361 ttattactat tatgaattga taatagctta tcatttgtta tgcctatgcc attatcctca
     9421 attgtaatta ttaaaaattc tttatctctg tgtagacgaa tattcacatt gcagccttcg
     9481 ggattatgga gaattgagtt atatataata ttatgaagta cgcgtgaaat taagtttttc
     9541 tcaattgaaa ttgtactatt ttgaagttta tcatcaaatt caaatgcaaa atttgaattt
     9601 tcccagactt cttgatttat tatttgtata atgattttcc tgaagaaaga aattattttg
     9661 actgattcta gttttagact aaactggtta ttagttaatc tggcaaaaat atttaagtca
     9721 tttatagtgt tttgaatata atagctctca ttaaggatgg atcgtaaacg tcttaattga
     9781 tttttatctg ctgtatcaga cttaataaga gaagcatttg aaataataac ggacagaggt
     9841 gtctttatat catgtgctat accagaaatc caattttctt taaaaagctc cccttcttta
     9901 agtttattgt cagcaatatt tatagcctcc gttaattgtt ttagctcatc ttgagttgca
     9961 acagagccac ttaggccttc tggtagtttt tgaattgctg aaactaaagg ggtaatttta
    10021 cgttggacta ctctagtact ataggtataa atgattaata gatacaggca atttattcca
    10081 agtagaaaaa aagctaaaat aaagaggttg tgaaggtcgg atttttcata ataattgaaa
    10141 ggaaatttaa acacattatc ttttgaaaat ccaaaaacaa gaatcttatt gttaataatt
    10201 tgtacgaata cagggtaatc atttaaataa taacgtgtaa acttagcgac gtcagttaga
    10261 ctatactgtg ttgggacttc acttggcttt ttatattcat aaatttcctt tccactatca
    10321 gagtctaaaa ccataatcca tacctcttta gaattagcta attttttacc caagttagat
    10381 aatttggcag aattagaact gatatcaagt tgtttgacta ggctactcac tgtatccatc
    10441 acattagttt gatttgcttg gctaaaaaca aaaaaaacta taataaaaat gtttattatg
    10501 gacattacta tgactgaaac aataaaacgt ctaataaatt gtgttactac acgtagttta
    10561 aacatgtata agctccctac accattagtt tgtagccaag tcctttaaca gtaaccaagt
    10621 attgtggctt tgaaggatta agttcgattt tttctctgat atttctaata tgaaccatta
    10681 aagatttttc atatccaaag ctatcaatac cccatactgt atcacaaatc gcttctgtag
    10741 atacaatata gtttttatta tcatacaatt ttcgaatgat ttgaatttct attggggtta
    10801 aagataattt ttcattatct ttttcaacaa ttgcattccc taaattaata atacaatgat
    10861 ctaatttaat agtattactg tcttctttgt acgatcgccg aagaagcgaa atcgtacgat
    10921 aaatgagaat tttaggtagg aaaggcttag ttataaaatc atctcctcca gattgtagac
    10981 cttgaatttc atcttcaggt tcattttttg ctgttagaaa aagaattgga atatcagatt
    11041 cttttctaac atattttgat aataaatacc cttccccgtc aggaagcatg acatctaata
    11101 taatcaaatc aatagaattt ttaacaaaag actctattcc ttcactgatg ctgtatgcac
    11161 tatatatttt tgagaaacca gaaactgaca gtatctccct tattgaatga tttaacgcaa
    11221 catcatcatc aacaaccaat attttcctag ccaaaaaagg cgcttcgata tccatgagct
    11281 ctcctagtga aataatttga attttccata tttatagtat atcaaaaata tcaagtaaaa
    11341 agtaagctca ctaaattctt taggttttct taaggtaaat tttgacattt ctttatcttg
    11401 tacctataaa atgtaattgt agctagataa agatgcttaa tattgattta aattaaacaa
    11461 ggagaaatat caatgaaatc aacaaataat caaagtatct cagaaattgc agcagtaaac
    11521 tcactacaag aagtaagtat ggaggaacta gaccaaatta ttggtgccgg aaacggagtg
    11581 gttcttactc ttactcatga atgtaaccta gcaacttgga caaaaaaact aaaatgttgc
    11641 taattattta acaagaaaat tttacttaag cattcaagta tttttatctg ttacatatta
    11701 agttgtgtta attaacttaa tggacttaaa agtttgaggt aaagatatct caaactttta
    11761 ttttttttga gataagatag atatttttac aaggaatgga tatttgatgt atgaagtata
    11821 accaactata tgaacaattt gataagtttc ctttatttat aattaaacag aaatttaatt
    11881 acaaatcatt ggagaattca aataatagaa aagtactaga aaaaattata ttagattact
    11941 ataggccaac attgatttac ttaattaatg aaaaaagggt caatggcgag ctaaaaggta
    12001 acactcctga ggaacgctat gattatttta atcaagaact atgtggtagt ggtaaaattt
    12061 ttggagaaat tgaaataaga tttccagaaa ttaatgatag aatcgaatta atagtgaaaa
    12121 aatacttaga cttgcacgag cgagtgaaat ctacttttgt aaaagacttt cggtttttgt
    12181 gtgataataa atttttacat tctgataaat tgaaacctga tttggataag cttgaaattg
    12241 aagttacggg tgatatacat gacggagcgg gagtgtgtat tatcagttat aataatcaaa
    12301 aggtagtata taaaagaaaa agttctatag caaatagatt tcttcgaaag atagatttaa
    12361 tggtaagtga attttttaac gaagagattc gttttattcc aaacatttta gatagagatg
    12421 gatatttttg ggaacaatat ataaataatc aaaaattgaa aaatgctaat gaggccaggg
    12481 aatactacac gaatatgggt ttcctattgt tttatgcgta tatttttaat atttcagatt
    12541 tacattttga aaatattctt tcttctggga aatcgccaat tttagttgac gtagaaactc
    12601 tctttagtac atcaccattt gaaataatag ctgataactt tgcaaccaag gagattactc
    12661 aaagaagccg atcctcggta ctttcatcag gattacttcc tatttctgaa gcagaaaaaa
    12721 tatttggagg agatttaagt gggatccttg gtggaacact agttaatgaa tttaaaacag
    12781 tcattaataa ctacagagat gatattagaa ttgaaaaagt tgttcaggca acaaaatatc
    12841 aatctcatct gccattcttt gaatatcttg gtcagaagga atatttagta gctactaatt
    12901 atgtaaatga cataatagct ggttttaagt tagtgagtga tttttttctt aatcataagg
    12961 aagaaattct ggaagtgtat cagcaatatt cagatttaaa aacacgaata ttgtttagaa
    13021 atactcatga atatgacgta gttagtcagt tgcttatttc tccaatatat tcccaaaaac
    13081 aagatttact ttttaaaaaa atgtcagaga agctaagtca ctatgatagt agtaaattgt
    13141 gtgaatcaga agttagacaa ttactcagta tggatatacc atctttctat attgaagcta
    13201 attctacaat agttaccgat ggatattcgg atgtttggaa aataaggaaa actcccttgt
    13261 attctgttac agagaaactt aacaaactaa ctgaagataa gatatctgaa caagttgaat
    13321 taataagatt ttcacttcaa gctgatcgtg attctgagag tacagaaatg caggaactgt
    13381 ataaaaaata tgatgatttt agaaatgaag agaatatcat gattaatgct ttgaataacc
    13441 ttgtagatga gatacttgca aaaatgtacc tagacccaga tgatgaaagt attaattgga
    13501 tgactttaaa agttaatgat cataacaatt ttgaattggt tccaatggat aattcaattt
    13561 atgatggtat ctcgggggta gcattaagtt taatagaatg ttattctttg ttagataaaa
    13621 atagaaaaag aaaagtttat agatgtttgt gttatttgtt taaaacactt gtaaatgtgt
    13681 attctaatat tttagatatg acctactatg ttggaagatt agggatacta tcaaccttag
    13741 taagaatatc tcaaattacc aaacaagaaa taccacaaaa aatattaaat agtaaagttt
    13801 ctttgattaa tcaggctttg caaaatacac cagcggattt tttaactgga ttttcgagtt
    13861 caatactagc ttgtgaagag gacgaatact cagaagagtt tcttcgaact atgataaatc
    13921 gcttcaaaga acttaaacaa tatgacagca atcataacta catttattgg ggaaaagaag
    13981 aaagtaataa tgttagctta gcacatggaa atgcaggtat cgaaatatca ttattatatt
    14041 tagccggaaa actcaagagt agagatgcta aggaaatgta tgaggatgct aaaaaatttg
    14101 atgataagca gagattagac caaggctgga tagataagag gttttcggat tcaaatgctc
    14161 aatggtgtca tgggtcaaca ggagtattaa tatctaggtt agctcagtta aagttaaatc
    14221 aggaatttaa aattttaagt atacaagaag aatccttgct tgtagaagat attcagcatg
    14281 caataaagca aattatctta ataggatttg atatgaataa ttttacttta tgtcacggag
    14341 tcggtggaaa ccttttagca ttaacttact ataataattt gtatgggggt gaaaatagct
    14401 cggaattaga agaaatcatt aattcggagt atagaaaaat gctttcattt ggaattaaat
    14461 atggttggat gtgcagtctt aataccaact tcgattctta tggtttaatg acaggacttg
    14521 caggaataat ttactcagta tcaaaatatt tgaaaagtga ttcttcgctt gaaattttaa
    14581 ctccggtctt ttgataaatg gggaagaata atgaaagtaa ttctacaaaa taatgaagag
    14641 gactgtttac tagcttgtta cacaatgcta ttgaatgatt taggctataa agtacctttg
    14701 tacgaggttt atgaaagaga ttcacttcca gctgatggct tgagtgtttc ctatttactg
    14761 actctgaata aaaactttaa tgtagatatt aaggcatata aggctaactt tgatgaagtt
    14821 attagtctaa tacgtgttag aggtaataat agggtgattg ttcattggaa taatgatcat
    14881 tttgttgttc tagaaaaaat aaccaaaaat tatataaaaa ttgtggatcc tgcaatagga
    14941 agaattaaat ttagtaagga tgaattttta gaacactatt ctggaacggt tattaccgta
    15001 ttaccgaccg ttgattttca tcgtcaaaaa gtgaggacgc tattttttaa atattttaaa
    15061 aacacactgg aagtaagagc aattttctct tttttgattt cgttactttt gattgaaatt
    15121 agtgttttgc tattttcaat tgtgataaga aatatggtgg ctggaaattt aaaatttatt
    15181 gcaagtcttc tcttattgtt tactattata ttactacaaa ttgttggata ttatattaag
    15241 aattttgcgc tagaaaaata taatagtaat tttgataaat cttacacaac tatcttattt
    15301 aagagattgc tcaataaacc attactatat tttagaaatc ataccaatgg aagtatttct
    15361 gaaaaaataa gtttcagaac gacattgaga gatagtgttg caactaaact aatcccttca
    15421 atagtaagtc tagtttcatc attcgtaatt tttatatatt tggtcataat ctcttttaga
    15481 ctaactataa tattagtttc tatgattgta ttatattctt taatatcatc tgttttatat
    15541 tataagcaga acgaatataa tcaatcttat ctacaatatc taattgattt taactcagat
    15601 tttcaatctg atctagaaga tatagattac attaaagtaa tgagaaacga gagggaaacg
    15661 gaagatagat ggacaaaaaa taatgatcgt ttgacaagca aatattccca aattttaaaa
    15721 gttgaaaatt ttgttcaact ttttggaagt atatttagct attttagttt atcaattgtt
    15781 atattagcag taatttataa taataaattt tttaatgttt caatagcaga tttagtatta
    15841 tatcaaacaa gtatttcatt attgatttca tctattgaac aagtgaaaac ctcaattttt
    15901 gaaatagcac gattagctat atatgctgaa aagcaggggg atatactaaa agaaaattta
    15961 ccaataaatg ttaattttga cttagattca aactatataa ttcagacaga aaatttaaac
    16021 tttggttatg gaaatgaatc actgtataaa ccagttaatt tgaaaattaa tcaaggtgaa
    16081 aagatagcaa ttataggtaa atcaggtagt ggtaaatcta cattgttatt attattgact
    16141 ggcatgttga gacattctgg caagattaca tataatagtg aacatctaga aaactatatg
    16201 ggagtaatct tgcaaaatat gacattgaaa aaaggaagtg tattagaaaa ctttgaatat
    16261 gactctcctg atttaactaa gctatcaaaa atacttgttg ataccacagc cgatgaggtc
    16321 attgctaaac ttcccaataa attgcaatcg aagttgttaa aacagggaaa gaatctttcg
    16381 ggaggacaaa tccagaaatt attaattgcc aaatcattgt tgaaaggtga aaaaatgatt
    16441 ttttgggatg aagcttttag taatttggat gaaatgagta aagataagat ttatgaaaat
    16501 gttttattgg gaagtttcta taaggataaa acgatgttaa ttgtaagtca ccacttggat
    16561 attgtgaact acgttgatag tgttatcttt ataaatgatg aaacaggaga agtcatcaaa
    16621 tcaactcacg aagatttaca aaagaacaac ttggattaca agagatttat ttgtaataaa
    16681 ggtgtctaat actttattat tggcattaac aaaaatttta aaatgaaagg tatggattat
    16741 acaatgacag aagtaataaa actaaaaaaa ttgaagaaaa attttaaagg agtatcgtca
    16801 gtcgatttag aaggacttac agttagaaaa ggtgaaattt atggtttcct tggtcctaat
    16861 ggagcaggta aaaccacgac aatgaagatg attctatcat taattgaacc tacttctggt
    16921 tcaattgaaa taatgaatac tccaattaac agatcgaacg attatttaaa atatataggt
    16981 tcaatgattg aagaaccttc ttactatccg aatttaacag gttacgaaaa tctattagtt
    17041 tttcaaaaaa tgttaggttt taaagaagag aatattttaa aaacacttga acttgtgggg
    17101 ctatcagaag aaaaaaatag aaaaaaatta gtaaaagcgt attctttagg tatgaaacag
    17161 cggttagctc tagcatttgc tttagtaaaa gaacctcaga tattattatt agatgaacct
    17221 acaaatggat tagatccctc aggtattcat gagatacgtg aattgattat tcgtttggct
    17281 aaagataagg gattaacagt tttcatttct agtcatattc tatctgaaat agagcagatt
    17341 gctgacaggg ttggaattat aaatcatggg agattagtat acgagggaga aattgaaaaa
    17401 ataaatacta ataattgggt agaaattgaa ggaaaatttg acattgaaaa attaaaaaat
    17461 ctttttggta atcattttag taatagaaaa gtggaatatg atgcaaaact tgttaaaatc
    17521 tggaatacta ataatgagca gatcgctaat atagtccgtt ccttgtttga attagacttt
    17581 ccaatttttc gtgtagaaca taaaaaagaa aatctcgaag atatattttt agaattaact
    17641 aaggagttat aaaatggtta atgctttaca aatagaattg ttaaaaagtc gtaggacaaa
    17701 atcgtttatt attacaatat ttctcatgtt cattggattc ttgtggaata cagttagtac
    17761 cggtagtgaa atcaattcag taaattatga tggagctagt gtgctattca ataatcaaac
    17821 aatgaatagc ctttttcttc ccatagctat tagtattttt accagccgta tagtttctaa
    17881 tgaacttgaa ggacagacat ttaagttaca ggaatcaaac ggaagaacat taattcaaat
    17941 tttttacagt aaattaattt tatcgactgt tttctttttg atattggcta ttttaggaac
    18001 agttgcaacg aatgtatttg caatggttaa cggagtaagt gttcctttaa caattactat
    18061 tattcaaatt ttaggacaac ttttgtcaag tttcagtctc atttgtattt atttaacttt
    18121 tgcaatgttt actgataaac aaggcttatt gttatcatca ggttttctag gtggatttat
    18181 aggtttaata ttagcatcca aatctacaat attctggacg tttgctatac cgtgggttgg
    18241 ctctgcttat ttatctcctt acaaatttac cctaataaat aattcaaact atctctataa
    18301 atttgaccaa tcaatatatt ttagattttt aatatatcta atttattgtt tacttttata
    18361 tcttcttgta agaagcatat ttttaaagaa agagagacaa agaaaatgag acattatact
    18421 tcagctgaat ggaaaaaact gaataaaatt cagattttaa tagtcggtgt tgtttttgta
    18481 gcattatcaa gttttatcgg tttaggtacc tattttgcta atcactcagt tttaattgat
    18541 ggtacacagg ataaagttat gtggggacaa ttaactttct attatactca gattctctat
    18601 tctccaatgc tcgcaatttt tattgcaata tctttaactc aagagtttga aagaaaaaac
    18661 ttggaaatgt tatgttcaaa tgcaatatct atcaaaaagt tactgataag caagctttta
    18721 acagttactg tattagttat tccaattcaa cttctcatac taattgttta tataatagct
    18781 ttagaagtag ctgatgtcga actctcttct tttgtcctat taactttaaa atggacactt
    18841 ttatctattt tgagctcttt atctatttta tgcatacaag catttgtcta tgctaaaact
    18901 agaagctttg gtcaatcaat tggtatttca gctatcggtg ctatgggcgg gttcgttcta
    18961 ttgtttttga atgaaaactt gaataaattt tatccgtatt ctcaacctat ggtagcattg
    19021 agaagtaggg ctttagatga tttttcatta ttagaactta ctatttttgt ctttgttaat
    19081 cttctgttta gtgtgatttt ttacagatta acatgttatg aactagaaaa aagaggataa
    19141 tataatttat ttaactgcct taattgattt ggttaattgt cgttatctaa caactgaact
    19201 gatctgctac tatagttaga tttgtgttgc aagtttatct aaatacatat tgatacgatt
    19261 atcatggtcg ctagtgttag ctgaaagagc atcctttatg atataatgtt ccaaacgata
    19321 caagctttac taattctcta tcttactatc agtataaata agaattgttt acgttgtatc
    19381 aatttatgat aagatattta ctgactctag aaagttagac aatttattta agcaaaggat
    19441 ttagttctgt actgtatagg attaagtcct tttctacctt ttgtcaagta tatcaaggta
    19501 tttgatgaaa aatagtttga gttccatagt caaactaagg aaattgtctt ttttaactat
    19561 aattcagtgt aaaaagtgta cactaaacca acaccttatc tggtgatttt ttgataaggc
    19621 gttactataa taatatggca taaacaattt tagcaatttt gggtagaagt ataatcgtaa
    19681 agtttgttat gtgttatgag gtaatacatt gttctaatga gacgatgtat agaggcaatt
    19741 gtgtgtggtt tggttgaagt ctcttgcgat tgtctttttt gttttagttt taccttaata
    19801 tgtttgttgt tgtaataatc aatatagcct acaatagctt gttcgaatag ataacaatga
    19861 tatttctgat ctgataggaa ttttgaaaga ctatttaagg atagaagtat aaagggagtg
    19921 aaaaaaagcg acaagggtag tccagatatg aagattgttt ataatttgaa gattaagaag
    19981 gaatagtttt tagctagtaa cagtggtggt caagtgtctt tctaacaaca agtcttgtca
    20041 cttattatgc atttcttcat cacaaacttc taggcagatt cattctgctt agaggttttt
    20101 tggtttgaac agatagaaat aaggttattc tttaccatga ttgtaagtaa acaatgagtt
    20161 tgattaatag aatcgtcaat aaactgctta ctttcgcttt aaactttact cagtccttta
    20221 atgagggagg cgttaaaatt gctaaaagtc ggaatttatg tgtgaattta agaaaatccg
    20281 aacgttcttt tggtaacgtt ttctaacata taaagacgat aggtatatat cttaggcttg
    20341 ttttttcaaa tggattatgg gtagaaggtt agtcttatga gactagggtt atgcatctgt
    20401 aattgtattc gcttccaaaa tcctttaaca tagtacagag aaataaagtt atattgaaag
    20461 gtgtatgtta tggaaaagaa agttggattt aagttgcaca aggtcaagaa aaactgggtg
    20521 actattggag ttagtacgct gtcgatggtt gcacttgcgg gtggagctct tttagcggac
    20581 caatcggcac aagcagatga agtgtcactt cctaatggag acggttttga acaaacagat
    20641 gcaggcattg agtcaagtgc ttcattgatt aatgaaagct attcgccaac cttgacagaa
    20701 gatgctggcc acttgtcagc agtgtcatct aactatggca gccaaacaaa ctcaggctac
    20761 gagtcttcat catctgcctc aacaggaggg tcatcacaga ctgtggtagg tggtagatct
    20821 ggtcaagtca gttcgtcaca atcttctcaa gtagtaggaa cacaaaactc taattcatca
    20881 caaacgggtt ctgcttacca atcaagtagc agctcggcat cagtaagtgc tagtgcatca
    20941 agttcgtcaa gctcatcaag ttcagcttgg tattcttact cgtcgtcatc atcatggtct
    21001 tcatcatcgt cagctagcgg ttttgcgaca attacgacaa gttcgtctga ctcaaacggc
    21061 attcattgga atggtggtcg aaacacgaca attaccatca cggcttcagg aacaacgccg
    21121 aatgtgacta tcgtttcgaa ctctaataaa ctgtttccaa acgtgacagt aggtcaatca
    21181 aacggttcaa atactaatgt cactatcatt tcacaaggaa atcaacaaaa taactcaggt
    21241 taccaaatca tcacaggtga gactaaacca agtgttgatt cgaacaatgc caagtcttca
    21301 tttgtccgtg taggcgaaaa tcaatggtat tattacgacc aatatggcca aaaggtcaaa
    21361 ggtgaaaagg ttatcgatgg taaggcttat tacttccttg aaaatggtct tcaagctcgt
    21421 gactcacttg ttaaaggtag cgatggctac acttattact atgataaaaa tggcgtgaaa
    21481 gctatcaacg gtttctacga ttttgcaggt taccgtaagg atgtccgcta tttcgactgt
    21541 tatggtcaca tggctactgg tcttcttgaa atgtgtggca caaccttcta ctttgataca
    21601 caaacaggta tccaagcgaa agacaagttt attcgcttct cagatggccg tatccgttac
    21661 ttcatcccta atactggtaa catggctgta aatacctttg ttcaaaataa agaaaaccaa
    21721 gcttggtact acctagatga acatggttac gctgtgacag gaaaacgcat catcaatggt
    21781 aaagaatact gctttgactc agaaggccgt caaatcaaag gtcagatgat gcaacaaggc
    21841 aacaagcatt actacatttc agctcaaaca ggtgaaatgg ctgtttcacg ctttatcttt
    21901 gaaaacaaca actggtatta tgcggatgct tttggttgcc tcgttcaagg tgcaaaagta
    21961 attgatggta aactctatta cttcaataaa gaccacagcc aattaaaagg tggctgggct
    22021 gaagggcgtt actatgatgc cgttactggt caagcagtca ttaaccaatt cattcaaatt
    22081 gcggctaacc aatgggctta ccttaaccaa gatggtcaca aagtaacagg tcttcaaaac
    22141 attaacaata aagtttacta ctttggtagc aacggtgctc aagtcaaagg taaattgctc
    22201 actgtccaag gtaagaaatg ctactttgat gcccacactg gtgagcaagt ggtgaaccgc
    22261 tttgtcgaag ctggccgtgg ttgctggtat tactttaacg cagcaggtca agcagtgact
    22321 gggaaacagg tcatcaatgg caaacaactt tacttcgacg gttcaggtcg tcaagtgaaa
    22381 ggacgttatg tctatgttgg tggtaaacgc cttttctgcg atgccaaaac tggtgaattg
    22441 agacagcgtc gctaattaat atgtacttta aaaatctaga gattttttcc ctttccaata
    22501 tcaattatta atttttccta tcaaatctct aggtgattaa ataattcaag agtctgagac
    22561 aaaaatagtt ttcagctaca aaaaagctag agattcccaa ccgtggaact ctagcttttt
//
