LOCUS       BGC0000551              6728 bp    DNA     linear   CON 06-FEB-2015
DEFINITION  Streptomyces coelicolor A3(2) complete genome.
ACCESSION   BGC0000551
VERSION     BGC0000551
KEYWORDS    .
SOURCE      Streptomyces coelicolor A3(2)
  ORGANISM  Streptomyces coelicolor A3(2)
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 13:49:53
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6728
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..6728
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[0:2793]"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..2793
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     cand_cluster    1..6728
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..6728
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000551"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..6728
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-iii"
                     /region_number="1"
                     /rules="(micKC and not PKS_KS)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..2793
                     /gene="SCO6681"
                     /gene_synonym="SC5A7.31"
     CDS             1..2793
                     /codon_start=1
                     /db_xref="GOA:O88037"
                     /db_xref="InterPro:IPR000719"
                     /db_xref="InterPro:IPR011009"
                     /db_xref="UniProtKB/TrEMBL:O88037"
                     /gene="SCO6681"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 78.9;
                     E-value: 7.6e-24)"
                     /gene_kind="biosynthetic"
                     /gene_synonym="SC5A7.31"
                     /note="SC5A7.31, unknown, len 930 aa; some similarity to
                     several e.g. PKN2_MYXXA serine-threonine-protein kinase
                     Pkn2 (Myxococcus xanthus) (830 aa), Smith-Waterman scores;
                     E: 1.5e-06, 23% identity in 829 bp overlap. Also has short
                     segment of similarity to the active site regions of several
                     Serine-Threonine protein kinases e.g. PKAA_STRCO P54739
                     serine-threonine protein kinase pkaA (533 aa), blastp
                     scores; Expect= 3.7e-05, 39% identity in 27 aa overlap.
                     Contains possible transmembrane anchor and six degenerate
                     repeats of the sequence VDETTR"
                     /product="putative serine/threonine protein kinase"
                     /protein_id="CAA19960.1"
                     /sec_met_domain="micKC (E-value: 2.7e-238, bitscore: 781.1,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 9.8e-13, bitscore: 36.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 6.5e-08, bitscore:
                     19.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAATVRGGTPRDSVVSVSNRWEGAGVNKGYAVYCDADPYFYDAP
                     HRTADRTGAARSRYAAASSPVPEGWQRHESGDWLALRPADADLPAQGWKIHVSACLDNA
                     ESVLDRVWRHCVDGGTAFKFVPSRYLLHQRNAKYADRAGSGKFVTVYPADEAEFERLVG
                     ELSELLAGEPGPHILSDLRIGDGPVHVRYGGFTRRDCYDADGELRPAVSGPDGVLVPDL
                     RGPVFRIPEWVDPPAFLRPHLDARSAVTVTGMPYTVESALHFSNGGGVYLARDTRTGAR
                     VVLKEARPHAGLAADGADAVTRLHRERRALERLSGLACTPEVLDHRTVGEHHFLVLEHI
                     DGKPLNTFFARRHPLIEADPGERRLAEYTDWALDVHARVERAVAEVHARGVVFNDLHLF
                     NIMVRDDDSVALLDFEAAHHVDEAGRQIVANPGFVAPPDRRGVAVDRYALACLRIVLFL
                     PLTSLLAVDRHKAAHLAEVVAEQFPVDRAFLDAAVEEITRVDGSTRVDGSTRADETTRA
                     DETTRLDVTTRVHGAPDAARRPAGPVAPVRPDDWPRSRDSMAAAIRASATPSRTDRLFP
                     GDIAQFATAGGGLAFAHGAAGVLYALAESGAGRDEDGEQWLLERTKRPPSGMPLGFHDG
                     LAGLAWTLERLGHRDRALDLAELLLDQPLDHLGPDLHGGTAGLGLALESLAATTGQAAL
                     HSAALHCAELAADGLPGGSVPADRVSRGRARAGLLYGGAGRALLFLRLFERTRDSALLD
                     LARDALRQDLARCVRGAGGALQVDEGWRTMPYLGAGSVGIGMVLDDYLAHRADEEFARA
                     ANEIVAAAQAMFYAQPGLYRGVAGMVLHLGRTTATAPGTGPRAVRRQLDALSWHAMSYR
                     DRLAFPGEQMMRLSMDLSTGTAGCLLAVASVLGDAPAGLPFLPPPRRSGGPLTRPHQEP
                     "
     repeat_region   1477..1584
                     /gene="SCO6681"
                     /gene_synonym="SC5A7.31"
                     /note="6x 18 bp repeats"
     regulatory      2819..2823
                     /note="possible RBS upstream of SC5A7.32"
                     /regulatory_class="ribosome_binding_site"
     gene            2831..2959
                     /gene="SCO6682"
                     /gene_synonym="SC5A7.32"
     CDS             2831..2959
                     /codon_start=1
                     /db_xref="GOA:O88038"
                     /gene="SCO6682"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SC5A7.32"
                     /note="SC5A7.32, unknown, len: 42 aa; similar to CDS
                     upstream of S. griseus RamA TR:Q07642 (EMBL:D13614) (43
                     aa), fasta scores; opt: 154 z-score: 293.0 E(): 4.4e-09,
                     53.7% identity in 41 aa overlap"
                     /product="hypothetical protein SC5A7.32"
                     /protein_id="CAA19961.1"
                     /transl_table=11
                     /translation="MNLFDLQSMETPKEEAMGDVETGSRASLLLCGDSSLSITTCN"
     CDS_motif       2831..2893
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MNLFDLQSMETPKEEAMGDVE"
                     /locus_tag="SCO6682_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       2894..2959
                     /prepeptide="core"
                     /locus_tag="SCO6682_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="32.20"
                     /molecular_weight="1955.2"
                     /monoisotopic_mass="1954.0"
                     /core_sequence="TGSRASLLLCGDSSLSITTCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNLFDLQSMETPKEEAMGDVE"
                     /leader_location="[2830:2893](+)"
                     /alternative_weights="1973.2"
                     /alternative_weights="1991.2"
                     /alternative_weights="2009.2"
                     /alternative_weights="2027.3"
                     /alternative_weights="2045.3"
                     /alternative_weights="2063.3"
     gene            2995..4905
                     /gene="SCO6683"
                     /gene_synonym="ramA"
     CDS             2995..4905
                     /codon_start=1
                     /db_xref="GOA:O88039"
                     /db_xref="InterPro:IPR001140"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR011527"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="UniProtKB/TrEMBL:O88039"
                     /gene="SCO6683"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 258.4; E-value:
                     2.3e-78)"
                     /gene_kind="transport"
                     /gene_synonym="ramA"
                     /note="SC5A7.33, ramA, probable ABC transporter, len: 636
                     aa; N-terminus contains transmembrane domain, C-terminus
                     contains ATP-binding domain. Almost identical to TR:Q53818
                     (EMBL:U03771) potential ATP-binding membrane transport
                     protein RamA (636 aa)(99.8% identity in 636 aa
                     overlap)Y08A_MYCTU hypothetical ABC transporter ATP-binding
                     protein MTCY50.10 (631 aa), fasta scores; opt: 556 z-score:
                     414.6 E(): 7.4e-16, 28.1% identity in 626 aa overlap.
                     Contains sixteen degenerate GA repeats at C-terminus,
                     PS00017 ATP /GTP-binding match to entry PF00005 ABC_tran,
                     ABC transporters, score 139.50, E-value 6e-38. Some
                     similarity to RamB (E(): 3.7e-05, 32.7% identity in 627 aa
                     overlap)"
                     /product="putative ABC transporter"
                     /protein_id="CAA19962.1"
                     /transl_table=11
                     /translation="MSPAAGAPGSGPGRRRLPALDVRRFSPVRKSRPVPPRAPGRALEV
                     LVLLCSVAAAVAAVAQPLALGRTLDLLLRDGDAGWWLPLSAALLLGELLLDSATSLFTG
                     RCNATWTASVRTRALRGLLRTAPEHARPYPPGDIGTRLTLNAADAGGAPAARAALAASL
                     ITPLGALVALALVDVWVALCVLTGLPALALLLRSFARDTGATVAAYQRTQSLIASRLLE
                     ALEGADTIGAAGTGERERARVLAPLAELAAQGRHMWALHGRALGRSGVLVPLLTLAATA
                     VGGLRLAAGELSVGDLLAVGRYAQLTAGVGAAASLLGAIVRAREARRRTRELERMTATV
                     YGTRRLPPNGPGELRLCGVRVLRGGREVLRADGVRVPGGSTVAVVGRSGAGKSVLAAVA
                     GRLIDPDEGYVLLDGVRLDRLTHEALRTEVAYAFERPVLGEGTIAEAVADGARRSSRER
                     VRQAARAAGADGFVRRLPHGYDTPLPRAPLSGGEHQRLGLARAFAHAGRLLVLDDATSS
                     LDTATEHEVDLALRRSVRPGTRLVVAHRPSVADRADLVLWLEDGQVRAVGTHRELWHTA
                     GYREVFGAGAGAGAGAGAGAGADAGAGADAGPGPDSGAATAVGGSGPGPVRRPEPEEAR
                     P"
     misc_feature    4129..4677
                     /gene="SCO6683"
                     /gene_synonym="ramA"
                     /note="Pfam match to entry PF00005 ABC_tran, ABC
                     transporters, score 139.50, E-value 6e-38"
     misc_feature    4150..4173
                     /gene="SCO6683"
                     /gene_synonym="ramA"
                     /note="PS00017 ATP /GTP-binding site motif A (P-loop)"
     repeat_region   4741..4836
                     /gene="SCO6683"
                     /gene_synonym="ramA"
                     /note="16 x 6 bp degenerate repeats"
     regulatory      4891..4894
                     /gene="SCO6683"
                     /gene_synonym="ramA"
                     /note="possible RBS upstream of ramB"
                     /regulatory_class="ribosome_binding_site"
     gene            4902..6728
                     /gene="SCO6684"
                     /gene_synonym="ramB"
     CDS             4902..6728
                     /codon_start=1
                     /db_xref="GOA:Q7AKE5"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR011527"
                     /db_xref="InterPro:IPR017871"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="UniProtKB/TrEMBL:Q7AKE5"
                     /gene="SCO6684"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 163.9; E-value:
                     9.7e-50)"
                     /gene_kind="transport"
                     /gene_synonym="ramB"
                     /note="SC5A7.34, ramB, probable ABC transporter, len: 608
                     aa; N-terminus contains transmembrane domain, C-terminus
                     contains ATP-binding domain. IdenticalTR:Q53819
                     (EMBL:U03771) potential ATP-binding membrane protein RamB
                     (608 aa) and similar tyo many e.g. Y07D_MYCTU hypothetical
                     ABC transporter ATP-binding protein MTCY02B10.13 (579 aa),
                     fasta scores; opt: 456 z-score: 443.0 E(): 1.9e-17, 31.8%
                     identity in 614 aa overlap. Contains sixteen degenerate PE
                     repeats between the N- andC-terminal domains. Also contains
                     PS00017 ATP /GTP-binding site motif A (P-loop), PS00211 ABC
                     transporters family signature and Pfam match to entry
                     PF00005 ABC_tran, ABC transporters, score 157.10, E-value
                     3e-43. Some similarity to RamA (E(): 2.7e-05, 33.4%
                     identity in 628 aa overlap)"
                     /product="putative ABC transporter"
                     /protein_id="CAA19963.1"
                     /transl_table=11
                     /translation="MTSTEAGALRRLAPPARRFLAHRKGVLVRLALWSLAESGQAFLVG
                     HAVARSVDEGFLAGDPRRGLLWLGVALVAVLSGARVVRGVFAQLAGVTEPLRDGLVRHA
                     VDRSMARAAPGGPGGTDRAAVSRLTNQVEIARDSFAGLVLTLRSFVFTAAGALLGLLSL
                     HPALLVVVLPPLAAGLALFLVTLRPMAAAQRRALAADEALGEHAASARAALRDLTACGT
                     GPGAERHGADLVADAAAAARTLAGWAAVRTAALGVAGHLPVLALLVAVEWLRGHGVSVG
                     ALLGAFTYLVQSLLPALHTLMTALGAAGSRLLVVLDRILGPEPEPEPEPEPEPEPELGS
                     GLEPEPEPASEPESGPSTASASAAAFAVHTAAAPAVELRSVTLSYGVRAEPVLDALDLR
                     VAPGEHLAVVGPSGIGKSTLTRLVAGTLAPSRGEVRVAGRVVTGRPAAELAALRVLVPQ
                     DAYVFSGTVGDNLAYLRTDPSPAELDAAVEAFGLAPLVERLGGLDATVRPAELSPGERQ
                     LVALVRAYLSPAPLLLLDEATCHLDPASEARAEKALAGRSGTLVVVAHRLSSAVRADRT
                     LVLDGIRAQSGTHAELLGRSPLYRDLTGHWNS"
     repeat_region   5865..5960
                     /gene="SCO6684"
                     /gene_synonym="ramB"
                     /note="16 x 6 bp degenerate repeats"
     misc_feature    6108..6644
                     /gene="SCO6684"
                     /gene_synonym="ramB"
                     /note="Pfam match to entry PF00005 ABC_tran, ABC
                     transporters, score 157.10, E-value 3e-43"
     misc_feature    6129..6152
                     /gene="SCO6684"
                     /gene_synonym="ramB"
                     /note="PS00017 ATP /GTP-binding site motif A (P-loop)"
     misc_feature    6432..6476
                     /gene="SCO6684"
                     /gene_synonym="ramB"
                     /note="PS00211 ABC transporters family signature"
ORIGIN
        1 gtgacagccg caactgtccg aggcggtacg ccgcgtgaca gcgtcgtctc cgtcagcaac
       61 cggtgggagg gagcaggcgt gaacaagggc tacgccgtgt actgcgacgc ggacccgtac
      121 ttctacgacg ccccgcaccg cacggccgac cggaccgggg ccgcgcgctc ccggtacgcc
      181 gccgcctcct cgccggtacc ggaggggtgg cagcgccacg agagcgggga ctggctcgcg
      241 ctgcgtccgg ccgacgccga cctgcccgcc caggggtgga agatccatgt ctccgcctgc
      301 ctcgacaacg cggagtccgt gctcgaccgg gtgtggcggc actgcgtcga cggcggtacg
      361 gccttcaagt tcgtgcccag ccgctacctg ctgcaccagc gcaacgccaa gtacgcggac
      421 cgggccggca gcggcaagtt cgtcaccgtg tacccggcgg acgaggcgga gttcgaacgg
      481 ctcgtgggag agctgtcgga actgctggcc ggcgagcccg gaccgcacat cctgagcgac
      541 ctgcggatcg gcgacgggcc cgtgcacgtc cgctacggcg gcttcacccg gcgcgactgc
      601 tacgacgcgg acggggaact gcggccggcc gtgtcaggac ccgacggtgt gctggtgccc
      661 gacctgcgcg gtccggtctt ccgcatcccg gagtgggtcg acccgcccgc cttcctgcgc
      721 ccgcacctcg acgcccgctc cgcggtgacc gtgaccggca tgccgtacac cgtcgagtcg
      781 gcgctgcact tctccaacgg cggcggcgtc tacctcgccc gcgacacccg caccggtgcg
      841 cgggtcgtcc tcaaggaggc ccgtccgcac gccgggctgg cggccgacgg cgccgacgcc
      901 gtgacccggc tgcaccgtga acgccgggcg ctggagcggc tgtcggggct cgcctgcacg
      961 ccggaggtgc tcgaccaccg cacggtcggg gagcaccact tcctcgtcct ggagcacatc
     1021 gacggcaagc cgctcaacac gttcttcgcc cgccggcacc cgctcatcga ggccgacccg
     1081 ggcgagcgga gactggccga gtacaccgac tgggccctcg acgtccacgc gcgggtggaa
     1141 cgcgccgtcg cggaggtcca cgcccggggt gtggtcttca acgacctgca cctgttcaac
     1201 atcatggtcc gggacgacga cagcgtcgcc ctgctggact tcgaggccgc ccaccacgtc
     1261 gacgaggcgg gacggcagat cgtggcgaac ccggggttcg tggcgcctcc cgaccggcgc
     1321 ggggtggccg tggaccggta cgcgctggcg tgtctgcgga tcgtgctgtt cctcccgctc
     1381 accagtctgc tggccgtcga ccggcacaag gcggcacacc tcgcggaggt ggtggcggag
     1441 cagttcccgg tggaccgggc gttcctggac gcggcggtcg aggagatcac gcgcgtcgac
     1501 gggagcaccc gcgtcgacgg gagcacgcgc gccgacgaga ccacgcgcgc cgacgagacc
     1561 acgcgcctcg acgtgaccac gcgcgtccat ggggccccgg acgcggcgcg gcggcccgcc
     1621 ggtccggtgg cgcccgtccg gccggacgac tggccgcgca gccgggactc catggcggcg
     1681 gcgatccgcg cctccgcgac gccctcccgc acggaccgcc tcttccccgg tgacatcgcg
     1741 cagttcgcca cggcgggcgg cgggctggcc ttcgcccacg gtgcggcggg ggtgctgtac
     1801 gccctggccg agagcggggc cggacgggac gaggacggcg agcagtggct gctggagcgg
     1861 accaagcgac cgccgtcggg catgccgctc ggtttccacg acgggctcgc cggactcgcc
     1921 tggaccctgg agcgcctcgg ccaccgcgac cgcgccctcg acctcgccga actcctcctc
     1981 gaccagccgc tcgaccacct gggcccggac ctgcacggcg gcaccgccgg tctcggcctg
     2041 gccctggagt cgctggccgc caccaccggt caggccgcgc tccactcggc ggcgctgcac
     2101 tgcgccgaac tggccgccga cgggttgccg ggcgggagcg tgccggccga ccgcgtcagc
     2161 cgcggccgcg cccgagccgg gctgctgtac ggcggcgcgg ggcgggccct gctcttcctc
     2221 cggctcttcg aacgcacccg ggactccgcc ctcctcgacc tcgcccgcga cgcgctgcgc
     2281 caggacctcg cccgctgcgt ccgcggcgcg ggcggcgcgc tgcaggtcga cgagggctgg
     2341 cgcaccatgc cctacctggg tgccggcagt gtgggcatcg gcatggtgct ggacgactac
     2401 ctggcgcacc gggcggacga ggagttcgca cgggccgcga acgagatcgt ggccgcggcc
     2461 caggcgatgt tctacgccca gcccgggctc taccggggcg tggccggaat ggtcctgcac
     2521 ctgggccgca ccacggccac ggcgcccggt acgggaccgc gggccgtacg gcgccaactg
     2581 gacgccctgt cctggcacgc catgtcctac cgcgaccggc tcgccttccc cggcgagcag
     2641 atgatgcgcc tgtccatgga cctctccacc ggaacggccg gatgcctgct cgccgtcgcc
     2701 tccgtcctcg gcgacgcgcc cgccggactg ccgttcctgc cgccgccgcg ccgaagcggc
     2761 ggccccctga ctcggcccca ccaggagccg tgagaaaagc acaccccttg ccgaacgaaa
     2821 ggaatgcgtc atgaacctgt tcgacctgca gtcgatggag acccccaagg aagaggccat
     2881 gggggacgtc gagaccggca gccgcgcgag cctcctgctc tgcggcgaca gcagcctgag
     2941 catcaccacc tgtaactgac acaggggttg acggccacgg cgacgtggtg agtcatgtcg
     3001 ccggccgcgg gcgccccggg ttccggcccg gggcgccgac gcctgccggc gctcgacgta
     3061 cggaggttct cgccggtgcg aaagagcagg cccgtgccgc cgcgggcgcc ggggcgcgcc
     3121 ctggaagtcc tggtcctgct gtgctcggtc gcggcggccg tggcggcggt ggcccagccc
     3181 ctggccctcg gccgcaccct ggatctgctc ctgcgcgacg gcgacgccgg atggtggctc
     3241 ccgctgagcg ccgcactgct cctgggtgaa ctgctgctgg acagcgcgac ctcgctgttc
     3301 accggccgct gcaacgccac ctggacggcg tccgtccgca cccgcgccct gcgtggactg
     3361 ctgcgcaccg cccccgagca cgcgcggccg tacccgccgg gcgacatcgg gacccgcctg
     3421 accctcaacg ccgccgacgc gggcggcgct ccggcggccc gcgcggcgct ggccgcctca
     3481 ctgatcaccc cgctgggcgc cctggtggcg ctggcgctcg tcgacgtgtg ggtggcgctc
     3541 tgcgtgctga ccggtctgcc cgccctggcg ctgctgctgc gctccttcgc ccgcgacacc
     3601 ggcgccacgg tcgccgccta ccagcgcacc cagtccctga tcgcctcccg gctgctggaa
     3661 gccctggagg gagcggacac gatcggtgcc gcgggaaccg gcgaacggga gcgggcccgt
     3721 gtcctggcac cgctggcgga actggccgcc cagggccggc acatgtgggc gctgcacgga
     3781 cgggcgctcg gccggagcgg tgtcctggtc ccgctgctga cgctggccgc caccgccgtc
     3841 ggcgggctgc ggctggcggc cggcgaactg agcgtggggg acctgctcgc cgtcggccgg
     3901 tacgcgcagc tcacggccgg cgtcggcgcg gcggcgtccc tcctcggggc gatcgtccgg
     3961 gcccgcgagg cacggcgccg gacccgggag ctggaacgga tgaccgcgac ggtgtacggc
     4021 acgcggcggc tgcctccaaa cggtccggga gagctgcgac tgtgcggggt gcgcgtgctg
     4081 cgcggcggca gggaggtgct gcgcgccgac ggcgtgcggg taccgggcgg cagcacggtc
     4141 gcggtggtcg gccgcagtgg ggcgggcaag tccgtcctgg cggccgtcgc gggacggctg
     4201 atcgaccccg acgaggggta cgtcctgctg gacggcgtcc ggctcgaccg cttgacgcac
     4261 gaggcgctgc gcaccgaggt ggcatacgcc ttcgaacggc ccgtactggg ggagggcacg
     4321 atcgcggagg cggtcgccga cggggcacgg cggtcgtcgc gtgagcgggt acgccaagcc
     4381 gcccgggcgg cgggcgccga cggcttcgta cgccggttgc cgcacggcta cgacaccccg
     4441 ctgccgcggg caccactgtc gggcggggag caccagcggc tcggactggc gcgggccttc
     4501 gcgcacgccg ggcggctgct ggtgctggac gacgccacgt ccagtctgga caccgccacg
     4561 gagcacgagg tggacctggc gctgcgtcgc tcggtgcggc cggggaccag gctcgtggtg
     4621 gcgcaccgcc cgtcggtcgc ggaccgggcc gacctggtgc tctggctgga ggacgggcag
     4681 gtgcgcgccg tcggaaccca tcgcgagctg tggcacacgg cggggtaccg ggaggtcttc
     4741 ggcgcaggag caggagcagg agcaggagcc ggagcaggag ccggagcgga tgccggtgcc
     4801 ggtgctgatg ccggtcccgg tcccgattcc ggtgccgcca ccgccgtcgg cggcagtggc
     4861 ccggggcccg tacgccgtcc ggagcccgaa gaggcgcgcc cgtgacgtcc acggaggccg
     4921 gggcgctgcg ccgcctcgca ccgccggccc gccgcttcct cgcccaccgc aagggggtgc
     4981 tggtacggct cgcgctctgg tcgctggccg agtcggggca ggccttcctg gtcggccacg
     5041 cggtcgcgcg ctccgtcgac gaggggttcc tcgccggtga tccgcgccgg ggactgctgt
     5101 ggctcggggt cgcgctggtc gccgtactgt ccggcgcccg ggtcgtccgg ggcgtgttcg
     5161 cgcagctcgc cggggtgacg gagccgctgc gcgacggcct ggtgcggcat gcggtcgacc
     5221 ggtccatggc ccgggcggca ccgggcggcc ccggcgggac ggaccgcgcg gccgtctcgc
     5281 ggctgacgaa ccaggtggag atcgcccggg acagcttcgc cggtctcgtc ctcaccctgc
     5341 ggtccttcgt cttcaccgcc gccggcgcac tgctcggcct gctgtccctg cacccggccc
     5401 tgctcgtggt ggtgctgccc ccgctggcgg ccgggctcgc gctgttcctg gtcacgctgc
     5461 ggcccatggc ggccgcccag cgccgggccc tggcggccga cgaggcgttg ggcgagcacg
     5521 cggcgagcgc gcgtgcggcg ttgcgggacc tcaccgcctg cgggaccggg cccggggcgg
     5581 agcggcacgg cgcggacctg gtcgccgacg ccgccgcggc ggcccggacg ctggccggat
     5641 gggcggcggt gcgcacggcg gcgctcggcg tcgcgggcca cctgcccgtg ctcgcgctgc
     5701 tggtggcggt ggagtggctg cgcgggcacg gggtgagcgt gggggcgctg ctgggcgcgt
     5761 tcacctacct cgtccagtcc ctgctgcccg ccctgcacac cctgatgacc gcactgggcg
     5821 cggccgggtc ccggctgctg gtcgtcctcg accggatcct cggcccggag ccggagccgg
     5881 agccggagcc ggagccggag ccggagccgg agttggggtc ggggctggag ccagagccag
     5941 agccagcgtc agagccagag tcggggccga gcaccgcgag cgcatcggcg gcggcattcg
     6001 cggtgcacac cgccgcggcc ccggcggtgg agctgcggtc cgtcaccctg tcctacggcg
     6061 tccgggccga gcccgtgctc gacgcgctcg acctgcgcgt cgcgccgggt gaacacctcg
     6121 ccgtcgtggg accgagcggc atcgggaagt ccaccctcac ccgcctcgtc gcgggaacgc
     6181 tcgcgccgag ccgtggcgag gtacgcgtgg ccggccgcgt ggtgacgggg cgccccgccg
     6241 ccgagctcgc cgcactccgg gtgctggtcc cgcaggacgc ctatgtgttc tccggcaccg
     6301 tcggcgacaa cctcgcctac ctgcggacgg acccgagccc ggccgaactc gacgccgcgg
     6361 tcgaggcgtt cggtctcgca cctctggtcg agcggctggg cgggctggac gccacggtgc
     6421 gccccgccga gctctcgccg ggggagcggc aactggtcgc gctggtccgc gcgtacctgt
     6481 cgcccgcccc cctgctgctg ctcgacgagg ccacctgcca tctcgatccg gcctccgagg
     6541 cccgcgcgga gaaggccctc gccgggcggt ccgggaccct ggtcgtggtg gcgcaccggc
     6601 tgtcctcggc cgtccgtgcg gaccggaccc tggtgctgga cggcatacgg gcgcagagcg
     6661 gaacgcacgc cgaactgctg ggccgttcgc ctctctaccg ggacctgacg ggacactgga
     6721 actcgtga
//
