LOCUS       BGC0000552             11776 bp    DNA     linear   BCT 01-FEB-2005
DEFINITION  Streptococcus mutans smbM1, smbF, smbT, smbM2, smbG, smbA, smbB
            genes, complete cds.
ACCESSION   BGC0000552
VERSION     BGC0000552
KEYWORDS    .
SOURCE      Streptococcus mutans
  ORGANISM  Streptococcus mutans
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 13:49:53
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11776
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..11776
                     /db_xref="taxon:1309"
                     /mol_type="genomic DNA"
                     /organism="Streptococcus mutans"
     protocluster    1..11776
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1388:8421]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1389..8421
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..11776
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..11776
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000552"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..11776
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1389..4265
                     /gene="smbM1"
     CDS             1389..4265
                     /codon_start=1
                     /gene="smbM1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     617.5; E-value: 7.2e-187)"
                     /gene_kind="biosynthetic"
                     /product="modifying enzyme for proSmb"
                     /protein_id="BAD72771.1"
                     /sec_met_domain="DUF4135 (E-value: 5.6e-69, bitscore:
                     221.9, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1e-74, bitscore:
                     240.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METRTDNIFIKLSDNSNIEKLYKKFGMNLLEDINASIDEFEVYES
                     WNRFHLLGSNTFSNLYLSFLEPYLLEIRNQLQKYDDNFQSDTIERTITENMLENISSLS
                     EGVWIAEMRNINKNQTEYLVYLNQDYKNLAEVVKKYPYWYFSIISFIRDTTKYLLEFLS
                     HLIQDKALVANQFLEADGMITDIKLSMGDRHRGTFVIKVESKFGNYFYKPRRSKLDTLF
                     KEVIDKIGEQDGILKMKAPKIIDQGSYSWAEEIRYIPLQSKNENERYYIRLGQLLAITY
                     ILNGSDLHYENIISCGEFPVAIDVETLLTSRLRFKKQTTPKMLQEDNINYLEDSVSNLI
                     ILPTIVKSNGDFYDLSPLKIYSGELPNTLAETWKKSNHLIQKNELKDVIGFIQRGFINI
                     YNEVLKDKERYKEYFNRLFNNVPIRYLNRETHDYSQILRLLKNPVCLFHFKYAFAVSMK
                     LLSEEIQEEEVLEYKELLKFNIPYFELDTDSTDLLLFDDKRIKNYFIETPLESLEHKLN
                     ILCEEDLERQLRLITQMLTVVSAEFDVKEINEVTIHEGESLQKQRAQTVEQMIATVFEN
                     KLINPLTKQYFWITPELEGDNNRSFYQIHENPDSYYSGSVGILRCLLLLEKSGYKDLPI
                     NKLISDIEIDIDAIINYGTVDTSIGAYNGIAQYLRYYAYIYKNNNFSVLSLKRIHYLLD
                     LIENGFKNDEKLDILDGTAGVILTLIEIFQLDLSDCLNNRVIKLVEKCRLHLIDSIIYD
                     KGEAYFPIAQEKNRYFTGFAHGSSGITLAIYRASKLLNIDDYTLIRSLLKTERRLFDKT
                     NQMWFKDNNRNSYSWGWCHGIPGILLSRLELIKHGYQDDYIIEEAYELYEIAIKKSLGV
                     NLTFCHGDLGNIVICKYAEVMLDIENSKVDKYIQEIFPYLTNATRYHIRGTETIGVMHG
                     LVGVATFLDSTICDNYLRFLDILKITSD"
     gene            4276..5100
                     /gene="smbF"
     CDS             4276..5100
                     /codon_start=1
                     /function="transportation and immunity of preSmb"
                     /gene="smbF"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 152.1; E-value:
                     3.3e-46)"
                     /gene_kind="transport"
                     /protein_id="BAD72772.1"
                     /transl_table=11
                     /translation="MRILDIQNLNFKYGKDYVLKNINLTLEQGDILGLVGENGAGKSTL
                     MKLISGIIPNYEGDIKIQAHNVGTLIEHPSLYADMTVLSNLKFYCRLFGKSYGVIDDYK
                     YVLQVDSYLHKKVSKLSLGMKQRVGLFIALIASEEFILLDEPTNGLDPIGIKNLLDLIK
                     KLSSEKGITFIISSHILQNLEQICNKAVLLRNHTISSLDAKKHMKYKIYHPDLSQSELI
                     CLLEDNGFDYEQNGRDIIVRDIDAIEEMLQREKNITIQKEKISLSEVYFDEQ"
     gene            5090..5806
                     /gene="smbT"
     CDS             5090..5806
                     /codon_start=1
                     /function="transportation of preSmb"
                     /gene="smbT"
                     /protein_id="BAD72773.1"
                     /transl_table=11
                     /translation="MSNKWATVLFVRPIIMKFSVFIFLMLSLLLGGGIIYSIENLKGPF
                     QVYNIYSVFSTVSNFLLMYAAINAFGREFRYKTINHLRISGRSSIEIILRKLLAVEFLA
                     ILTSLVSFVEVAFYKIYFNHPQIDLFEIFNHLVPAYLVYALFLFSLGSIITLVLKNSLY
                     SFITLFLTLRLGVTIMNVMNNFESTADLTKYIPLSFVENAFSFAKYTPEQYVVTIVWSV
                     ALMALLPVIYRKWGYA"
     gene            5791..8421
                     /gene="smbM2"
     CDS             5791..8421
                     /codon_start=1
                     /gene="smbM2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     268; E-value: 2.7e-81)"
                     /gene_kind="biosynthetic"
                     /product="modifying enzyme for proSmb"
                     /protein_id="BAD72774.1"
                     /sec_met_domain="DUF4135 (E-value: 1.6e-48, bitscore:
                     154.6, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.1e-17, bitscore:
                     51.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLCIVENIRNSAYPSIEGKFENYFSHYISKIYEQLLSIDSKGLF
                     SSQNDQEKCYYALIEGILKNISSVAISSLIDYYQEERAINPNLSYKDYNENLQKDRYFQ
                     EFHQIYPTVKDNCEVVICNYIQRTKEVFSLLQNYQVEIRNVASLKESESLSLSNLNIFE
                     GDFHINTFVAILTLNEKRILIKKRPNLGDRLLRIFQKYFDKENIKLPIANTIFLDDDLC
                     LQEYIKSDSAVLNSIELQNFYYKFGIMTVIFTILGSKDLHSENIISTKYGPYFIDLEAA
                     ITDTLNREKLDSLLTETYLFNSKEKRLVYGSLDLSAFSGGDITTRRYGVIHKGQDDINI
                     GVYSYTEKHSNIPQDINGAKVNPEEYSADVLKGFDTGIRIFLKYKERLIQKLELIESYD
                     YRVVLRNTAFYGKYLDDLNLPMYTKSKEKSEKYIHLLRKHSKRDKKIVDKEMACLKQQA
                     IPYFLISEVTDNKIIKDNLIKRIEGLSLSDLNKEKYYLQLILGLDVPIEGRSHYLDNGN
                     KVDNELQAFESFCSNDVGFKFGVIDHTVQNTLLHYCNDIYTFGASLLFLARYCKNSKLR
                     EKIITTVRNGGTSEGLSGLIGRQSSYLLYHYFNLESEKQNYTSSKDIVHEKDIVDFSTY
                     GSAILVLNYLYKETSNKAYLDDIKLLGEIYLKTYTKRNLTGLFHGYAGDILVLSVLRQY
                     IEHQTIDKDILDLIQLENSNFNKVSNNWNDTRHNISNTEDLCALSYGAVGILFSRHLLY
                     RSSNLYKKLKDIVMTDLFKALNCILVRNRSDYVDDSLVNGYAGALVVLKIILQSGLLNN
                     HYSKLIKVKTYIEEGEKLLENTQWRYEQFNNLLNPSFFSGRLGTAFTLWFISQNDFYIE
                     KFLGV"
     gene            8458..10554
                     /gene="smbG"
     CDS             8458..10554
                     /codon_start=1
                     /function="transportation and immunity of preSmb"
                     /gene="smbG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 233; E-value: 1.2e-70)"
                     /gene_kind="transport"
                     /protein_id="BAD72775.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 5.6e-31, bitscore:
                     96.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQTECGLCVAVMLMEYYDVRITLNDIPKEFSAGRDGTRIRGLKK
                     IFDHFGFSMNMFKVTDRLSEIKNSSLPGIAYRIGGHFVVVESISSNEVIILDPAFGRTK
                     ISKDELDNDYKNLILKITPNENFKTVNTRGQEFSLIKEAVFFNKKLVVQVLIAAVIVYS
                     LTLVAPLLLKGLVDNFLVSKQIDTTIWALSIGTIASSLVYFVVNRVKQITSIRLSISVD
                     KFLSKKVVDKLFKNKFEFYLNRTSSDIQYRLVLLKNLKTIISDIIIQTFLDIGSMVVIL
                     IYIMNLQPLYAVFLAFITLLVLSMSRFMREKMLLYKNKELATDSKLQVFQYDIFRAIFD
                     VKVLGLSSKKHRSWHRYYEDYIKSHEKNQRFITLYQNILAYITLYVPIFIPILGIWISG
                     LAHSNQVGTIISLQSITGTYISGLISIAQLSDNITTAKSYLIRIDDILLQEDEAVRNRT
                     IDFKGNIRVNNLSFVYPGAEDKTLDDISFSINEGESVAIVGESGSGKSTLFYILLGAYD
                     NYEGDIYFEGLDLKILNKDALREQIGVVPQDALLFNGSIKENLIEDFEVADNDIYDALK
                     KVTLLDFVYSLPMGINTVVSENGFNFSGGQRQRLALARAILNQKSMLFLDEATSALDNI
                     TEHQIVEYLSEDSKTKIVIAHRLSTIKNSDKIIVLKDGQVSEVGDHHSLMAQKGEYYRM
                     YSGK"
     gene            10653..10838
                     /gene="smbA"
     CDS             10653..10838
                     /codon_start=1
                     /gene="smbA"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /product="SmbA precursor"
                     /protein_id="BAD72776.1"
                     /transl_table=11
                     /translation="MKSNLLKINNVTEMEKNMVTLIKDEDMLAGGSTPACAIGVVGITV
                     AVTGISTACTSRCINK"
     CDS_motif       10653..10742
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MKSNLLKINNVTEMEKNMVTLIKDEDMLAG"
                     /locus_tag="smbA_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       10743..10838
                     /prepeptide="core"
                     /locus_tag="smbA_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-1.70"
                     /molecular_weight="2807.3"
                     /monoisotopic_mass="2805.5"
                     /core_sequence="GSTPACAIGVVGITVAVTGISTACTSRCINK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKSNLLKINNVTEMEKNMVTLIKDEDMLAG"
                     /leader_location="[10652:10742](+)"
                     /alternative_weights="2825.3"
                     /alternative_weights="2843.3"
                     /alternative_weights="2861.3"
                     /alternative_weights="2879.4"
                     /alternative_weights="2897.4"
     gene            10866..11054
                     /gene="smbB"
     CDS             10866..11054
                     /codon_start=1
                     /gene="smbB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_ha"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /product="SmbB precursor"
                     /protein_id="BAD72777.1"
                     /sec_met_domain="mature_ha (E-value: 3.6e-17, bitscore:
                     50.7, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEIQKAGLQEELSILMDDANNLEQLTAGIGTTVVNSTFSIVLGN
                     KGYICTVTVECMRNCSK"
     CDS_motif       10866..10952
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MKEIQKAGLQEELSILMDDANNLEQLTAG"
                     /locus_tag="smbB_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       10953..11054
                     /prepeptide="core"
                     /locus_tag="smbB_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.00"
                     /molecular_weight="3395.0"
                     /monoisotopic_mass="3392.7"
                     /core_sequence="IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKEIQKAGLQEELSILMDDANNLEQLTAG"
                     /leader_location="[10865:10952](+)"
                     /alternative_weights="3413.0"
                     /alternative_weights="3431.0"
                     /alternative_weights="3449.0"
                     /alternative_weights="3467.0"
                     /alternative_weights="3485.1"
ORIGIN
        1 aaaacgttgt caatcctgat gatgttgtcg aacaatatgg tgctgatacc cttcgtgttt
       61 acgaaatgtt catgggaccg cttgacgctt ctattgcatg gtctgaagaa ggccttgaag
      121 gcagccgcaa attccttgat cgtgtctacc gtcttatcac aacaaaagaa atagctgcca
      181 aaaacaatgg acacttagac aagatttata atgaagtagt taaaaccgta acagagcatc
      241 ttgaagctat gcgttttaac acagctattt ctcaattgat gatttttgtc aatgctgcta
      301 acaaggaaga acaactgcta acaggagaca ctctttcttg attatgctaa gggatttatt
      361 caattattgg cgccgtttgc accgcattta gctgaagagc tttggcaggt attgacgcag
      421 tcaggtgaat ctctttctta tgttacttgg ccaagctatg atgaatccaa attggtcgaa
      481 gacgaaatcg agattgtcct tcaaatcaaa ggaaaagttc gtgccaaggt tggtgttcct
      541 aaggattcca gccgtgaaga tcttgaaaaa attgctcttg ccaacgacaa aatccaagca
      601 gagattgcag gaaaagatat tgtaaaagtt attgcagtgc ctaacaaact ggttaatatt
      661 gttgtgaaat aaaaattgaa gactggacaa ttccaatcct tgatcacatg gaaaatggga
      721 caacaatatt ggggaaatta gagaatttta tagacaaggt cggagagtta gcagatccac
      781 tcgttcccat gtttttaaga gaaaatttga agcagttact agaatcacag tagatgagtc
      841 tgggacaatg tcttcccgac taacgtaaaa agcaacggtt ttgatgccgt tgctttttgt
      901 tgttgtagag atagtcttaa taaaataaaa aatatcggaa gatttgagac cttaggctca
      961 aatcttaggt atggaattct gaaggctgaa atagtcataa agctatttca gattgggaca
     1021 taaggaaacg aaagtttcct catcgctact gtccgtatca cctaagaaaa gtctcaaaag
     1081 aagacttttt atacattttc agtatactat ttttttatga aaaaatcatg gattttcttg
     1141 aaaaagtaat ctttttctta ggatacataa tgtaaaaata gctggtaatg atagtttcag
     1201 aacatcaaaa atgaccgttt aagacaaaat agctaccgtt taggatattt cgctccattt
     1261 tgaaaataaa ttgttatact aaagatgttg gttgcgcagc cagataaaaa attaatttca
     1321 tatttaggaa tatcagaaaa atatgatttt agatagtaaa atggtaaaaa cttggtaagg
     1381 gggaagttgt ggaaacaagg actgataata tttttattaa gttaagtgat aattcaaata
     1441 ttgaaaaatt gtacaaaaaa tttgggatga atctattaga agatataaac gctagcatag
     1501 acgagtttga ggtttatgag tcctggaata gatttcatct tcttggcagc aatacttttt
     1561 ctaatttgta tttatcattt cttgagccgt atttacttga gataagaaat caattacaga
     1621 aatatgatga caattttcaa agtgatacca ttgaacgaac tataacagag aatatgttag
     1681 aaaatatttc ttctctatct gaaggtgtct ggatagcaga gatgagaaat atcaataaaa
     1741 atcaaactga atatttagtt tatttaaatc aggactataa aaatttagca gaagttgtta
     1801 agaagtatcc ttactggtat ttttcaataa tttcatttat aagagatacc acaaagtatt
     1861 tactagagtt tctttctcat ttgattcaag ataaagcctt ggttgctaat cagtttttgg
     1921 aagcagatgg aatgataacg gatattaaac tatctatggg agacagacat agaggaacat
     1981 ttgtcatcaa ggtagaatca aaattcggta attattttta taaaccgaga agaagtaagt
     2041 tagatacatt atttaaagaa gttatagata aaatagggga gcaagatgga atattaaaaa
     2101 tgaaagctcc taaaattatt gatcaaggaa gctattcttg ggctgaagaa attcgatata
     2161 tcccattaca atcaaagaat gaaaatgaga gatattatat taggctggga cagttattgg
     2221 ctattacata tatacttaat ggcagcgatt tacattatga aaatattata tcttgtggag
     2281 aatttcctgt agcaatagat gttgagacac ttttgactag tagattgagg ttcaagaagc
     2341 aaacgactcc aaaaatgtta caagaggata atattaacta tttggaggac tctgtaagta
     2401 atttgataat attacctaca attgtaaaaa gtaatggaga tttttatgat ttgagcccgc
     2461 tgaaaatata tagtggagag ttaccaaata ctcttgcaga aacttggaaa aaatctaacc
     2521 atctaatcca aaaaaatgaa ttgaaagatg tcataggttt tatacagaga ggttttatta
     2581 atatttataa tgaggttctc aaagataaag agcgctataa agaatatttc aatcgattat
     2641 ttaacaatgt tcctattcgc tatttaaata gagaaaccca tgactattcg caaatattaa
     2701 gactattaaa gaatccggtg tgcctatttc attttaaata cgcttttgca gtatcaatga
     2761 aacttttaag cgaggaaata caggaagaag aagtactaga atacaaagaa ttgttaaagt
     2821 ttaacatccc atattttgaa ttagacactg atagtactga tttactttta tttgatgata
     2881 agagaataaa aaactacttt atagaaacgc ccctagaaag cctagagcat aaactaaata
     2941 tactatgtga ggaggatctt gaaagacaat taagactaat aactcaaatg ctgacagtag
     3001 tttctgcaga atttgacgta aaagagataa atgaagtaac aattcatgag ggagagagtc
     3061 tacaaaagca aagggcgcag acggttgaac aaatgattgc aactgttttt gaaaataaac
     3121 tgataaatcc attaactaaa caatattttt ggataactcc tgaattagaa ggtgataata
     3181 atagaagttt ttaccaaatt catgaaaatc ctgatagtta ttattcgggt agcgttggaa
     3241 tactgagatg tttgctactg ctcgaaaaat caggctataa agatttacct attaataaat
     3301 taataagtga tattgaaatt gatatagatg caattattaa ttatggaaca gtggacacca
     3361 gcatcggtgc ttacaacgga atagctcagt atttaagata ttatgcttat atatataaga
     3421 ataacaactt cagtgtctta tctttgaaac gcatccatta cttattagac ttaatagaaa
     3481 acggctttaa aaatgatgag aaattggaca tcttagatgg aacggcaggt gtcatattaa
     3541 ctttaataga gatttttcaa ttagatttga gtgactgttt aaataatcgt gtgattaaat
     3601 tagttgagaa atgtcgctta catctaatag attcgattat ttatgataag ggggaagcct
     3661 attttcctat tgcacaggaa aaaaatcgtt attttactgg tttcgcacat ggatcatctg
     3721 gaattacttt agctatttac agagcaagca agctattaaa tatagatgac tataccctta
     3781 ttcgatcgtt actaaaaaca gaaagacgct tatttgataa gacaaatcaa atgtggttta
     3841 aggacaataa tagaaacagc tattcatggg gatggtgcca cggaattcca ggtattcttt
     3901 tatcgagact tgagcttata aaacatggct atcaggatga ctatattatt gaagaagctt
     3961 atgaattata tgagatcgct ataaaaaaat ccctaggtgt gaatttaact ttttgtcatg
     4021 gtgacctagg gaacattgtt atttgtaaat atgctgaggt gatgcttgat attgaaaata
     4081 gtaaggtaga taaatacatt caagaaatct ttccttattt aacaaatgca acgaggtatc
     4141 acattcgagg aactgaaacc ataggagtga tgcatggttt agttggggta gctacttttt
     4201 tggacagtac gatttgtgat aactatctta ggtttttgga tattttaaaa ataacatcag
     4261 attaaggagg ctgacatgag aattttagac attcaaaatt taaattttaa atatggaaaa
     4321 gattatgtat tgaaaaacat taatcttact ttagaacaag gagatatcct aggcttagtt
     4381 ggtgaaaatg gtgctggtaa gtcaactttg atgaagctta tttcaggtat cattcctaac
     4441 tatgaaggag atatcaagat tcaagctcat aatgttggta ctttaattga acaccccagc
     4501 ctctatgctg atatgacagt gttgagtaat ttgaagtttt actgtcgtct atttggcaag
     4561 agttacggcg tcattgatga ttataaatat gttttacagg tggatagtta tttacataaa
     4621 aaagtttcaa aactatcttt ggggatgaag cagagagttg gactgtttat tgctctcatt
     4681 gcttctgaag agtttatctt attagatgaa ccgaccaatg gtctggatcc tattggtatt
     4741 aaaaatttac tggacttaat aaaaaaatta tcatctgaaa aaggtattac ttttattatt
     4801 tccagccaca tcttacaaaa tttggagcaa atctgcaaca aagcagttct gctgagaaat
     4861 cacacaatta gcagcttgga tgctaagaaa catatgaaat ataagattta tcatcctgat
     4921 ttatctcaat ctgagctaat ctgcttatta gaagataatg gtttcgacta tgaacaaaat
     4981 ggtagggata ttattgttcg tgatattgat gccattgaag aaatgttaca aagagagaag
     5041 aatattacta ttcagaagga aaaaataagt ttgagtgagg tatattttga tgagcaataa
     5101 atgggcaacg gtcttgtttg taagaccaat tattatgaaa tttagtgtat ttatttttct
     5161 gatgctatcc ctattgcttg gtgggggaat catctattct attgagaatt taaaaggacc
     5221 ttttcaggtt tataatatct acagtgtatt ttctactgtt tccaatttct tattgatgta
     5281 tgcagctatc aacgcctttg gtagagagtt tcgctataaa actatcaatc atcttagaat
     5341 cagtgggcga tcaagtattg aaattatttt gagaaaatta ttagcagttg agtttttagc
     5401 tattttgact agcttagttt cctttgtaga agttgcattt tataaaattt attttaatca
     5461 tccgcagatt gatttatttg aaatttttaa tcatctggta ccggcttact tagtttatgc
     5521 gctatttctc ttttcattag gaagcattat cacattagtt ttaaaaaatt cattatattc
     5581 attcatcact ctattcctta cattaagatt aggggtgact atcatgaatg ttatgaataa
     5641 ttttgaatct acagctgatt tgactaaata tattccttta tcatttgttg aaaatgcctt
     5701 tagttttgct aaatacactc cggaacagta tgttgttact attgtttgga gtgttgcatt
     5761 gatggcatta ttgcctgtga tttatcgtaa atggggttat gcatagtgga aaacataaga
     5821 aattcggcct atcccagtat agagggcaaa tttgaaaact atttttctca ctatatttca
     5881 aagatatatg agcaattatt atctattgat tcaaaaggac tattcagcag ccaaaatgac
     5941 caagaaaaat gttactatgc acttattgag ggtattttaa agaatatatc atcagtagca
     6001 attagttctc taatcgacta ttatcaggaa gaaagggcta taaatcctaa tttatcatac
     6061 aaagattata atgaaaatct tcaaaaagat agatattttc aagaatttca tcagatttat
     6121 ccaacagtga aagataattg tgaagttgtt atttgtaatt atattcaaag gactaaagaa
     6181 gtatttagcc tacttcaaaa ttaccaagta gaaataagaa acgttgctag tttaaaagaa
     6241 agtgagtcgc tgtctcttag taatcttaat atctttgaag gtgatttcca tattaataca
     6301 tttgtagcta tacttacact aaatgaaaaa agaatattga tcaagaagcg tcccaattta
     6361 ggggatcgtc ttttgagaat ttttcaaaaa tattttgaca aggaaaatat caaactacct
     6421 attgcaaata caattttctt agacgatgac ttgtgccttc aagaatacat caagtcagac
     6481 agtgcagttt taaatagcat agaactccaa aatttttatt ataaattcgg aattatgaca
     6541 gttattttta caattttagg aagtaaggac cttcatagtg agaatattat ttctacaaaa
     6601 tatggtccct attttattga tttagaagct gctataacgg acacactaaa tagagaaaaa
     6661 ttagactcac tattgacaga aacttatcta tttaattcta aagaaaaaag acttgtatat
     6721 ggttcactag atttaagtgc atttagtgga ggtgatataa ccactcggcg gtatggtgtc
     6781 attcataagg ggcaagatga cattaatata ggagtctaca gttatactga aaagcatagt
     6841 aatataccac aagatataaa tggtgccaag gttaatcctg aagagtattc agcagatgta
     6901 ctgaaaggtt tcgatacagg aattagaatt tttctaaaat ataaggagag gttaattcag
     6961 aaactagaat taatagagag ctatgattat agggttgtac ttcgtaacac ggctttttat
     7021 ggcaaatatt tagatgattt aaacttacca atgtacacta agagtaagga aaaatcagaa
     7081 aaatatatcc acctattgag gaagcacagt aagcgcgata aaaaaatagt tgacaaagaa
     7141 atggcttgtt tgaaacaaca agctatccct tattttttaa tcagcgaagt aactgataat
     7201 aaaataatta aggacaacct cataaagaga attgaggggc ttagccttag tgatttaaat
     7261 aaagaaaaat actatttgca gctaattttg ggattagatg ttccaataga aggacgatct
     7321 cattatttgg ataatggaaa caaagtggat aatgaactac aagcatttga atcattttgc
     7381 tcgaatgatg tgggttttaa atttggagtg attgatcaca ctgttcagaa tacgctatta
     7441 cattattgta atgatatata tacatttggc gcttctctct tgtttttagc tagatattgc
     7501 aaaaatagta aattgagaga aaaaataata actacagtca gaaatggtgg cacaagtgaa
     7561 ggtctttctg gactaatagg tagacaatcg tcgtacttac tctatcatta ttttaattta
     7621 gaatctgaga agcaaaacta cacatcctca aaagacatag tacatgaaaa agatattgta
     7681 gatttttcaa cgtatggaag tgccattctg gttttaaact atctctacaa agaaacttca
     7741 aataaggctt atctagatga tataaaacta ttaggagaaa tatatttaaa gacgtacact
     7801 aagcgtaatc ttactggttt gtttcatgga tatgcaggcg atattttagt gttatcagtt
     7861 ctccgccaat atatagaaca tcagactatt gataaagata ttctcgacct tattcaactc
     7921 gagaattcta attttaacaa agtttctaat aattggaatg atactaggca caatatttct
     7981 aatactgagg atctatgtgc attatcgtat ggagctgtgg gaatactttt tagtaggcac
     8041 ttactctatc gttcatccaa tctttacaag aaattaaaag atattgttat gactgatctc
     8101 tttaaagctc ttaattgtat tttggtcaga aataggagcg attatgtaga tgattctcta
     8161 gttaatggct atgcaggtgc tcttgtagtt ctaaaaataa ttttacaatc aggcttgttg
     8221 aataaccatt atagtaaatt gataaaggtc aaaacctata tagaagaagg agaaaaatta
     8281 ttagaaaata cccaatggcg ttatgagcaa tttaataatc ttttaaatcc ttcatttttt
     8341 agtggaagat taggcacagc atttacttta tggttcataa gccaaaatga tttttatatt
     8401 gaaaagtttt tgggggtgta ggaaattaaa aagaaaaaaa ttacaccact tctacagatg
     8461 agccaaacag aatgtggatt atgtgttgct gtaatgttaa tggaatacta tgatgttcgc
     8521 ataactttga atgatattcc taaagaattc tctgcgggaa gagacgggac gcgtattagg
     8581 ggacttaaga aaatttttga ccactttggt ttttccatga atatgtttaa ggtgactgat
     8641 agactctcag aaataaaaaa ctcctcgtta ccaggcatcg cttatagaat cggaggacat
     8701 tttgtcgtag tagagtcaat ctcttctaat gaggttatta tattggatcc agcttttggg
     8761 cgaacaaaaa tttcaaaaga tgaacttgat aatgactata aaaatttaat acttaagata
     8821 acgcctaacg aaaattttaa aaccgttaat actagaggac aagaattttc actgattaaa
     8881 gaagcagtat tctttaacaa gaaactcgtt gtacaggtgc ttattgcagc ggtaattgtc
     8941 tattcgttga cactagttgc tccgttacta ttaaaaggac ttgttgataa ttttttagtt
     9001 agcaaacaga tagatactac aatttgggcg ctatctatag gtacaatcgc aagcagtttg
     9061 gtctactttg tagtgaatag agtcaagcaa attactagca tccgtctgtc tatctccgtt
     9121 gataaattct tatcaaaaaa ggttgttgat aaattattta aaaataaatt tgaattttat
     9181 cttaaccgta ctagctcgga tatccaatat agattagtac tattaaaaaa tttaaaaacg
     9241 ataattagtg atattatcat tcaaactttt ttagatatag gttctatggt tgttatcctc
     9301 atttacatta tgaatttaca acctttatat gcagtctttt tagcatttat tacattgcta
     9361 gtattatcca tgagcaggtt tatgcgagag aaaatgttgc tgtacaaaaa caaggagttg
     9421 gcaacggata gtaaattgca agtttttcag tatgatattt ttcgtgcaat ttttgatgta
     9481 aaagtgttag ggctaagctc aaaaaagcat aggtcgtggc atagatatta tgaggattat
     9541 atcaagtctc atgaaaaaaa tcagcgattt atcactttgt atcaaaatat actagcatat
     9601 attacacttt atgtaccaat tttcattcct atcttaggaa tttggattag tggattggct
     9661 cacagtaacc aagttggaac gattatatct ttacaatcga ttacaggtac atacatttca
     9721 ggtctaatct ccatagctca attatcagac aatattacaa cagcaaagtc ttacctcata
     9781 cgtatagatg acatcctttt gcaggaggac gaagcagtaa gaaatcgtac aatagatttt
     9841 aaagggaata taagggtaaa caacttgtca tttgtctatc ccggtgccga agacaaaaca
     9901 ttagatgata ttagtttttc aattaatgaa ggcgagtctg tagccattgt tggcgaaagt
     9961 ggttctggta agtctacgtt gttttatata ttgttaggtg cttatgataa ctatgaaggt
    10021 gatatatact ttgaaggact agatttaaag attttaaaca aagatgcttt acgtgagcag
    10081 ataggagtgg ttcctcagga tgccttattg tttaacggaa gtataaaaga aaatttaatt
    10141 gaagatttcg aggttgctga taatgatata tatgacgctc taaaaaaagt tactctgctt
    10201 gattttgttt attcattgcc tatggggatt aatacagtag tatcggaaaa tgggttcaac
    10261 ttctcaggag gacagagaca gagactagct ttggccagag ctattttaaa tcaaaaatca
    10321 atgctattct tagatgaagc aacgagtgct cttgataata ttactgagca tcaaattgta
    10381 gaatatttat ctgaagattc taaaacaaag attgttattg ctcatagatt aagcactata
    10441 aaaaatagtg acaaaataat tgttttaaaa gacggtcaag tgtctgaagt tggagaccat
    10501 catagcttga tggctcaaaa gggagaatat taccgaatgt attctggtaa ataatatatt
    10561 gagcaataac ttttgggtgg ccgggtggga caaggagaag ataggagcat tatgatgata
    10621 ggtagtttat aaagaatagg aaggaatata aaatgaaaag taatttatta aaaataaata
    10681 atgtaacaga gatggaaaaa aatatggtaa cgctcatcaa agatgaagat atgttagctg
    10741 ggggctctac tccggcatgt gcaattgggg ttgttggtat tactgtagca gttactggta
    10801 tatcaactgc gtgcacatct cgctgtatta acaaataagt aattagaaaa taggagtaaa
    10861 ttataatgaa agagattcaa aaagcaggct tgcaagaaga gttatcaatt ctcatggatg
    10921 atgctaataa cttagaacaa cttactgctg gtattggtac aacagtagta aattctactt
    10981 ttagcattgt attgggaaat aaaggttata tctgtacggt tactgttgaa tgcatgagaa
    11041 attgtagtaa gtaatacgta ttagtgaata ttaattttat agactactta catgatgata
    11101 aatattccta tctaatagtc ttatttaatt atattgatca gttagtcaat gtggttagta
    11161 agactttttt tgtctcattg tcaactgtag tgggcgactt atagctaaag acaaaagttg
    11221 tcttctcttt tgttatattc aaagcgaggg aagtgtgttt cttaaagttg tcaaagtttc
    11281 tatacccaaa agcattttgc ttaatgtcct tgatgagttt gtttgtagct tcaagtttgg
    11341 cattagaata aggcagttca atggcattag tgatatagtt tttatagcga ataaagatgt
    11401 ttaaagcagt tttgaaggtg tgattaagat gtggaagcgc ctcgtttatt aagctaaata
    11461 agcgttcggc attcttgttt tgtaaatgaa aaaaggagta actcatagag gtcataataa
    11521 tcttttagtt ccggaaccag tttgaagatc ttattgagaa cactctctag gcgtcatggt
    11581 ttctctaaat gttctagagt agaaagtatt aagagagagt tttctgctat ctttttgaat
    11641 gatcttccag tagtatttca gtgcccgata ttccagcgat ttcttatcaa atagcttcat
    11701 gatttgaata cgggtttgct tgagtgctct attcatgtgc tgaacaatat gaaagcggtc
    11761 aagaacgatt ttggta
//
