BGC0000552 - 1 region(s) - antiSMASH results

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	1	11,776	High	SmbA/SmbB	ribosomal:RiPP:Lanthipeptide

Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 11,777
Label		BGC0000552

Tailoring functions

Lyases: cyclase

smbM1: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

smbM2: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000552.3	1.00	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0000497.3	0.87	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000623.3	0.53	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0002663.2	0.52	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0002698.2	0.52	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001229.4	0.52	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000626.3	0.52	ribosomal	thuricin	Bacillus thuringiensis
BGC0001311.5	0.51	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000552.3	1.00	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0000497.3	0.87	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000623.3	0.53	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0002663.2	0.52	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0002698.2	0.52	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001229.4	0.52	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000626.3	0.52	ribosomal	thuricin	Bacillus thuringiensis
BGC0001311.5	0.51	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for smbM1

smbA

Leader:

MKSNLLKINNVTEMEKNMVTLIKDEDMLAG

Core:

GSTPACAIGVVGITVAVTGISTACTSRCINK

Core with dehydrations:

GDhaDhbPACysAIGVVGIDhbVAVDhbGIDhaDhbACysDhbDhaRCysINK

antiSMASH-DB 4.0 matches for smbA

96.8%

NC_018089.1and 13 others:

NC_018089.1 Lanthipeptides: SMUGS5_RS08730_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04350_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04350_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09070_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09070_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00320_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00320_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03990_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03990_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08125_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08125_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05520_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05520_lanthipeptide

Lanthipeptides: SMUGS5_RS08730_lanthipeptide

2

STPACAIGVVGITVAVTGISTACTSRCINK

31

STPACAIGVVGITVAVTGISTACTSRCINK

1

STPACAIGVVGITVAVTGISTACTSRCINK

30

41.9%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

3

TPACAIGVVGITVAVTGISTACTSRC

28

TPA +I V G T STACT C

2

TPAISILVSGFISTNTCPSTACTRAC

27

40.6%

NZ_NUML01000015.1:

Lanthipeptides: COD66_RS20140_lanthipeptide

2

STPACAIGVVGITVAVTGISTACTSRC

28

+TPA VVGI+V + +T CTS+C

7

TTPATPTIVVGISVGLCP-TTKCTSKC

32

with 21 more sequence matches

Only the first 10 are displayed here.

39.4%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00700_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00700_lanthipeptide

2

STPACA---IGVVGITVAVTGISTACTSRCIN

30

STP CA + + A+ I+TACT+RC +

1

STPGCAWAAVSAISTVSALFQITTACTTRCYH

32

38.7%

NZ_JAMXMK010000009.1:

Lanthipeptides: NGM22_RS28125_lanthipeptide

2

STPACAIGVVGITVAVTGISTACTSRC

28

STPACA VG+T+A G C

7

STPACA---VGVTIAAWGAHKLSYWNC

30

37.5%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

2

STPACAIGVVGITVAVTGISTACTSRC

28

+TPA VV I+V + +T CTS+C

7

TTPATPTIVVAISVGLCP-TTKCTSKC

32

31.4%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

10

VVGITVAVTG---ISTACTSRC

28

++G T+AVT +T CTSRC

14

IIGATIAVTASLCPTTKCTSRC

35

31.0%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

6

CAIG--VVGITVAVTGIS------TACTSRC

28

CA+G VGIT+ S +AC+SRC

11

CAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

29.0%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide

Lanthipeptides: LDO05_RS02090_lanthipeptide

10

VVGITVAVTGISTACTSRC

28

+ G+ A STACTS+C

10

ICGVASAAFCPSTACTSKC

28

27.9%

NZ_KL997439.1and 1 other:

NZ_KL997439.1 Lanthipeptides: IQ62_RS33140_lanthipeptide

Lanthipeptides: IQ62_RS33140_lanthipeptide

1

GSTPACAIGVVGITVAVTGISTACTSRC

28

G+ P C I V + AV +T CTS C

17

GTGPWC-IATVTLVSAVACPTTKCTSSC

43

25.8%

NC_014622.2and 5 others:

NC_017542.1 Lanthipeptides: PPM_RS22280_lanthipeptideNZ_CP029370.1 Lanthipeptides: DI243_RS20990_lanthipeptideNZ_CP034141.1 Lanthipeptides: EGM68_RS21685_lanthipeptideNZ_PNXP01000027.1 Lanthipeptides: C1I59_RS20700_lanthipeptideNZ_POVS01000032.1 Lanthipeptides: C1T21_RS26405_lanthipeptide

Lanthipeptides: PPSC2_RS50140_lanthipeptide

2

STPACAIGVVGITVAV

17

STP + V+G+TV V

7

STPTITVTVIGVTVLV

22

25.8%

NC_023037.2and 11 others:

NZ_CP017967.2 Lanthipeptides: PPYC1_RS07755_lanthipeptideNZ_CP017968.3 Lanthipeptides: PPYC2_RS08330_lanthipeptideNZ_CP061172.1 Lanthipeptides: IAQ67_RS07480_lanthipeptideNZ_CP073683.1 Lanthipeptides: KAI37_RS07495_lanthipeptideNZ_CP109848.1 Lanthipeptides: OF859_RS22650_lanthipeptideNZ_CP113973.1 Lanthipeptides: OYT09_RS07785_lanthipeptideNZ_FOYG01000001.1 Lanthipeptides: BM358_RS03525_lanthipeptideNZ_JAAMNR010000001.1 Lanthipeptides: G9G54_RS03500_lanthipeptideNZ_PNXQ01000013.1 Lanthipeptides: C1I60_RS14430_lanthipeptideNZ_POVS01000009.1 Lanthipeptides: C1T21_RS10630_lanthipeptideNZ_PTJM01000020.1 Lanthipeptides: C5G87_RS02825_lanthipeptide

Lanthipeptides: X809_RS07820_lanthipeptide

3

TPACAIGVVGITVAVTGIST

22

TP+CA G + V++T T

6

TPSCATGTLNCQVSLTFCKT

25

25.8%

NZ_CM000752.1and 15 others:

NZ_CM000752.1 Sactipeptides: BTHUR0007_RS37430_sactipeptideNZ_JABGBR020000007.1 Sactipeptides: HOV72_RS15955_sactipeptideNZ_JABGBR020000007.1 Sactipeptides: HOV72_RS15950_sactipeptideNZ_JYPH01000039.1 Sactipeptides: TU52_RS33370_sactipeptideNZ_JYPH01000039.1 Sactipeptides: TU52_RS33365_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29070_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29065_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29060_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31360_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31355_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31350_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30820_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30815_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30810_sactipeptideNZ_NUXK01000018.1 Sactipeptides: COJ27_RS31850_sactipeptide

Sactipeptides: BTHUR0007_RS37435_sactipeptide

5

ACAIGVVGITVAVTGISTA

23

AC++ ++ + A TG STA

11

ACSVELLNLVTAATGASTA

29

MIBiG 4.0 matches for smbA

16.2%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

21

STACTSRC

28

+T CTSRC

30

TTKCTSRC

37

16.1%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

21

STACTSRC

28

+T CTS+C

19

TTKCTSKC

26

smbB

Leader:

MKEIQKAGLQEELSILMDDANNLEQLTAG

Core:

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

Core with dehydrations:

IGDhbDhbVVNDhaDhbFDhaIVLGNKGYICysDhbVDhbVECysMRNCysDhaK

antiSMASH-DB 4.0 matches for smbB

100.0%

NC_018089.1and 11 others:

NC_018089.1 Lanthipeptides: SMUGS5_RS08725_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptide

Lanthipeptides: SMUGS5_RS08725_lanthipeptide

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

33

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

33

93.9%

NZ_CP043405.1and 1 other:

NZ_CP043405.1 Lanthipeptides: FY406_RS04355_lanthipeptide

Lanthipeptides: FY406_RS04355_lanthipeptide

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCS

32

IGTTVVNSTFSIVLGNKGYICTVTVECMRNC

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCQ

32

50.0%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide

Lanthipeptides: IE257_RS28650_lanthipeptide

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

33

I TV + S LGN G++CTVTVEC +NC +

2

IFETVTYTVASWALGNNGHLCTVTVECQKNCQR

34

with 101 more sequence matches

Only the first 10 are displayed here.

48.6%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

1

IGTTVVNST---FSIVLGNKGYICTVTVECMRNC

31

IGTTV + S LGN G CT TVEC NC

3

IGTTVTTLSCYGVSWALGNDGNFCTATVECQSNC

36

48.5%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNCS

32

+TFS+ VLGN G CT+TVEC NC+

4

NTFSLSDVLGNTGGWCTLTVECQPNCN

30

45.5%

NZ_CP016795.1and 5 others:

NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide

Lanthipeptides: BC342_RS18360_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNCS

32

+TFS+ LGN G CT+T EC NCS

4

NTFSLSDALGNHGGWCTLTKECQPNCS

30

45.5%

NZ_CP047419.1and 3 others:

NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide

Lanthipeptides: GTU71_RS12805_lanthipeptide

9

TFSIVLGNKGYICTVTVECMRNC

31

T S VLGN+G CT+TVEC NC

7

TLSNVLGNQGGWCTLTVECQPNC

29

45.5%

NZ_KV795763.1and 2 others:

NZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptideNZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptide

Lanthipeptides: allorf_248182_248337_lanthipeptide

4

TVVNSTFSIVLGNKGYICTVTVECMRNCS

32

T +S V+GN+G +CTVTVECM C

1

TAFPGWYSKVIGNRGRVCTVTVECMSVCQ

29

44.1%

NZ_BQXZ01000001.1and 1 other:

NZ_BQXZ01000001.1 Lanthipeptides: OCU69_RS05000_lanthipeptide

Lanthipeptides: OCU69_RS05000_lanthipeptide

9

TFSIVLGNKGYICTVTVECMRNCSK

33

T S+ +GNKG +CT T+EC NCSK

10

TLSVYMGNKGSVCTWTIECQSNCSK

34

42.4%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

11

SIVLGNKGYICTVTVECMRNCS

32

S LGNKG CT+TVECM +C+

11

SCRLGNKGAYCTLTVECMPSCN

32

42.4%

NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20295_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptide

Lanthipeptides: BLI_RS20295_lanthipeptide

10

FSIVLGNKGYICTVTVECMRNCS

32

S LGN GY+CTVT ECM +C+

10

LSKPLGNNGYLCTVTKECMPSCN

32

42.4%

NC_018499.1and 10 others:

NC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27860_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25275_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25270_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27570_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27565_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27560_lanthipeptide

Lanthipeptides: BCK_RS27860_lanthipeptide

5

VVNSTFSIVLGNKGYICTVTVECMRNCS

32

V S LGNKG CT+T ECM +C+

5

VTPEGLSSWLGNKGGYCTLTKECMPSCN

32

42.4%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNCS

32

+TFS+ LGN+G CT+T EC NC+

4

NTFSLSDFLGNQGGWCTLTKECQPNCN

30

MIBiG 4.0 matches for smbB

42.4%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

11

SIVLGNKGYICTVTVECMRNCS

32

S LGNKG CT+TVECM +C+

7

SCRLGNKGAYCTLTVECMPSCN

28

42.4%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

8

STFSI--VLGNKGYICTVTVECMRNCS

32

+TFS+ LGN G CT+T EC NC+

4

NTFSLSNALGNNGGWCTLTKECQPNCN

30

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

21

CTVTVECMRNC

31

CT++ EC NC

28

CTLSKECQPNC

38

Lanthipeptide(s) for smbM2

smbA

Leader:

MKSNLLKINNVTEMEKNMVTLIKDEDMLAG

Core:

GSTPACAIGVVGITVAVTGISTACTSRCINK

Core with dehydrations:

GDhaDhbPACysAIGVVGIDhbVAVDhbGIDhaDhbACysDhbDhaRCysINK

antiSMASH-DB 4.0 matches for smbA

96.8%

NC_018089.1and 13 others:

NC_018089.1 Lanthipeptides: SMUGS5_RS08730_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04350_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04350_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09070_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09070_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00320_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00320_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03990_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03990_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08125_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08125_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05520_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05520_lanthipeptide

Lanthipeptides: SMUGS5_RS08730_lanthipeptide

2

STPACAIGVVGITVAVTGISTACTSRCINK

31

STPACAIGVVGITVAVTGISTACTSRCINK

1

STPACAIGVVGITVAVTGISTACTSRCINK

30

41.9%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

3

TPACAIGVVGITVAVTGISTACTSRC

28

TPA +I V G T STACT C

2

TPAISILVSGFISTNTCPSTACTRAC

27

40.6%

NZ_NUML01000015.1:

Lanthipeptides: COD66_RS20140_lanthipeptide

2

STPACAIGVVGITVAVTGISTACTSRC

28

+TPA VVGI+V + +T CTS+C

7

TTPATPTIVVGISVGLCP-TTKCTSKC

32

with 21 more sequence matches

Only the first 10 are displayed here.

39.4%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00700_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00700_lanthipeptide

2

STPACA---IGVVGITVAVTGISTACTSRCIN

30

STP CA + + A+ I+TACT+RC +

1

STPGCAWAAVSAISTVSALFQITTACTTRCYH

32

38.7%

NZ_JAMXMK010000009.1:

Lanthipeptides: NGM22_RS28125_lanthipeptide

2

STPACAIGVVGITVAVTGISTACTSRC

28

STPACA VG+T+A G C

7

STPACA---VGVTIAAWGAHKLSYWNC

30

37.5%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

2

STPACAIGVVGITVAVTGISTACTSRC

28

+TPA VV I+V + +T CTS+C

7

TTPATPTIVVAISVGLCP-TTKCTSKC

32

31.4%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

10

VVGITVAVTG---ISTACTSRC

28

++G T+AVT +T CTSRC

14

IIGATIAVTASLCPTTKCTSRC

35

31.0%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

6

CAIG--VVGITVAVTGIS------TACTSRC

28

CA+G VGIT+ S +AC+SRC

11

CAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

29.0%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide

Lanthipeptides: LDO05_RS02090_lanthipeptide

10

VVGITVAVTGISTACTSRC

28

+ G+ A STACTS+C

10

ICGVASAAFCPSTACTSKC

28

27.9%

NZ_KL997439.1and 1 other:

NZ_KL997439.1 Lanthipeptides: IQ62_RS33140_lanthipeptide

Lanthipeptides: IQ62_RS33140_lanthipeptide

1

GSTPACAIGVVGITVAVTGISTACTSRC

28

G+ P C I V + AV +T CTS C

17

GTGPWC-IATVTLVSAVACPTTKCTSSC

43

25.8%

NC_014622.2and 5 others:

NC_017542.1 Lanthipeptides: PPM_RS22280_lanthipeptideNZ_CP029370.1 Lanthipeptides: DI243_RS20990_lanthipeptideNZ_CP034141.1 Lanthipeptides: EGM68_RS21685_lanthipeptideNZ_PNXP01000027.1 Lanthipeptides: C1I59_RS20700_lanthipeptideNZ_POVS01000032.1 Lanthipeptides: C1T21_RS26405_lanthipeptide

Lanthipeptides: PPSC2_RS50140_lanthipeptide

2

STPACAIGVVGITVAV

17

STP + V+G+TV V

7

STPTITVTVIGVTVLV

22

25.8%

NC_023037.2and 11 others:

NZ_CP017967.2 Lanthipeptides: PPYC1_RS07755_lanthipeptideNZ_CP017968.3 Lanthipeptides: PPYC2_RS08330_lanthipeptideNZ_CP061172.1 Lanthipeptides: IAQ67_RS07480_lanthipeptideNZ_CP073683.1 Lanthipeptides: KAI37_RS07495_lanthipeptideNZ_CP109848.1 Lanthipeptides: OF859_RS22650_lanthipeptideNZ_CP113973.1 Lanthipeptides: OYT09_RS07785_lanthipeptideNZ_FOYG01000001.1 Lanthipeptides: BM358_RS03525_lanthipeptideNZ_JAAMNR010000001.1 Lanthipeptides: G9G54_RS03500_lanthipeptideNZ_PNXQ01000013.1 Lanthipeptides: C1I60_RS14430_lanthipeptideNZ_POVS01000009.1 Lanthipeptides: C1T21_RS10630_lanthipeptideNZ_PTJM01000020.1 Lanthipeptides: C5G87_RS02825_lanthipeptide

Lanthipeptides: X809_RS07820_lanthipeptide

3

TPACAIGVVGITVAVTGIST

22

TP+CA G + V++T T

6

TPSCATGTLNCQVSLTFCKT

25

25.8%

NZ_CM000752.1and 15 others:

NZ_CM000752.1 Sactipeptides: BTHUR0007_RS37430_sactipeptideNZ_JABGBR020000007.1 Sactipeptides: HOV72_RS15955_sactipeptideNZ_JABGBR020000007.1 Sactipeptides: HOV72_RS15950_sactipeptideNZ_JYPH01000039.1 Sactipeptides: TU52_RS33370_sactipeptideNZ_JYPH01000039.1 Sactipeptides: TU52_RS33365_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29070_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29065_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29060_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31360_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31355_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31350_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30820_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30815_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30810_sactipeptideNZ_NUXK01000018.1 Sactipeptides: COJ27_RS31850_sactipeptide

Sactipeptides: BTHUR0007_RS37435_sactipeptide

5

ACAIGVVGITVAVTGISTA

23

AC++ ++ + A TG STA

11

ACSVELLNLVTAATGASTA

29

MIBiG 4.0 matches for smbA

16.2%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

21

STACTSRC

28

+T CTSRC

30

TTKCTSRC

37

16.1%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

21

STACTSRC

28

+T CTS+C

19

TTKCTSKC

26

smbB

Leader:

MKEIQKAGLQEELSILMDDANNLEQLTAG

Core:

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

Core with dehydrations:

IGDhbDhbVVNDhaDhbFDhaIVLGNKGYICysDhbVDhbVECysMRNCysDhaK

antiSMASH-DB 4.0 matches for smbB

100.0%

NC_018089.1and 11 others:

NC_018089.1 Lanthipeptides: SMUGS5_RS08725_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptide

Lanthipeptides: SMUGS5_RS08725_lanthipeptide

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

33

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

33

93.9%

NZ_CP043405.1and 1 other:

NZ_CP043405.1 Lanthipeptides: FY406_RS04355_lanthipeptide

Lanthipeptides: FY406_RS04355_lanthipeptide

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCS

32

IGTTVVNSTFSIVLGNKGYICTVTVECMRNC

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCQ

32

50.0%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide

Lanthipeptides: IE257_RS28650_lanthipeptide

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

33

I TV + S LGN G++CTVTVEC +NC +

2

IFETVTYTVASWALGNNGHLCTVTVECQKNCQR

34

with 101 more sequence matches

Only the first 10 are displayed here.

48.6%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

1

IGTTVVNST---FSIVLGNKGYICTVTVECMRNC

31

IGTTV + S LGN G CT TVEC NC

3

IGTTVTTLSCYGVSWALGNDGNFCTATVECQSNC

36

48.5%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNCS

32

+TFS+ VLGN G CT+TVEC NC+

4

NTFSLSDVLGNTGGWCTLTVECQPNCN

30

45.5%

NZ_CP016795.1and 5 others:

NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide

Lanthipeptides: BC342_RS18360_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNCS

32

+TFS+ LGN G CT+T EC NCS

4

NTFSLSDALGNHGGWCTLTKECQPNCS

30

45.5%

NZ_CP047419.1and 3 others:

NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide

Lanthipeptides: GTU71_RS12805_lanthipeptide

9

TFSIVLGNKGYICTVTVECMRNC

31

T S VLGN+G CT+TVEC NC

7

TLSNVLGNQGGWCTLTVECQPNC

29

45.5%

NZ_KV795763.1and 2 others:

NZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptideNZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptide

Lanthipeptides: allorf_248182_248337_lanthipeptide

4

TVVNSTFSIVLGNKGYICTVTVECMRNCS

32

T +S V+GN+G +CTVTVECM C

1

TAFPGWYSKVIGNRGRVCTVTVECMSVCQ

29

44.1%

NZ_BQXZ01000001.1and 1 other:

NZ_BQXZ01000001.1 Lanthipeptides: OCU69_RS05000_lanthipeptide

Lanthipeptides: OCU69_RS05000_lanthipeptide

9

TFSIVLGNKGYICTVTVECMRNCSK

33

T S+ +GNKG +CT T+EC NCSK

10

TLSVYMGNKGSVCTWTIECQSNCSK

34

42.4%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

11

SIVLGNKGYICTVTVECMRNCS

32

S LGNKG CT+TVECM +C+

11

SCRLGNKGAYCTLTVECMPSCN

32

42.4%

NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20295_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptide

Lanthipeptides: BLI_RS20295_lanthipeptide

10

FSIVLGNKGYICTVTVECMRNCS

32

S LGN GY+CTVT ECM +C+

10

LSKPLGNNGYLCTVTKECMPSCN

32

42.4%

NC_018499.1and 10 others:

NC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27860_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25275_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25270_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27570_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27565_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27560_lanthipeptide

Lanthipeptides: BCK_RS27860_lanthipeptide

5

VVNSTFSIVLGNKGYICTVTVECMRNCS

32

V S LGNKG CT+T ECM +C+

5

VTPEGLSSWLGNKGGYCTLTKECMPSCN

32

42.4%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNCS

32

+TFS+ LGN+G CT+T EC NC+

4

NTFSLSDFLGNQGGWCTLTKECQPNCN

30

MIBiG 4.0 matches for smbB

42.4%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

11

SIVLGNKGYICTVTVECMRNCS

32

S LGNKG CT+TVECM +C+

7

SCRLGNKGAYCTLTVECMPSCN

28

42.4%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

8

STFSI--VLGNKGYICTVTVECMRNCS

32

+TFS+ LGN G CT+T EC NC+

4

NTFSLSNALGNNGGWCTLTKECQPNCN

30

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

21

CTVTVECMRNC

31

CT++ EC NC

28

CTLSKECQPNC

38

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Identified secondary metabolite regions using strictness 'relaxed'

Legend:

Lanthipeptide(s) for smbM1

antiSMASH-DB 4.0 matches for smbA

MIBiG 4.0 matches for smbA

antiSMASH-DB 4.0 matches for smbB

MIBiG 4.0 matches for smbB

Lanthipeptide(s) for smbM2

antiSMASH-DB 4.0 matches for smbA

MIBiG 4.0 matches for smbA

antiSMASH-DB 4.0 matches for smbB

MIBiG 4.0 matches for smbB

Legend: