Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000553.1:
Cluster 1RiPP17440

BGC0000553, SRO15-2212 biosynthetic gene cluster from Streptomyces roseosporus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: SRO15-2212
Exact molecular mass: 2212.18 Da ([M+H]+)
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
RiPP subclass:
Lantipeptide (cyclic)
Peptides in this cluster:
RiPP core peptide sequence(s): TGSQVSLLVCEYSSLSVVLCTP
Leader peptide length: 21
Follower peptide length: -1
Peptidase(s) involved in precursor cleavage:
Crosslinks in final product:
3=10 AA (Thioether)
13=20 AA (Thioether)

Gene cluster description

SRO15-2212 (BGC0000553). Gene Cluster 1. Biosynthetic class = RiPP. GenBank NZ_DS999644, positions 5221350-5228789. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
Comments:The SRO15-2212 prepropeptide sequence is identical with AmfS from Streptomyces griseus IFO13350
Contact for this cluster:Neha Garg (University of California at San Diego)

Literature references

1. Kersten RD et al. (2011) A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nat Chem Biol 7(11):794-802. doi: 10.1038/nchembio.684.