BGC0000554 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000554 (Streptomyces filamentosus NRRL 15998)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-ii	1	6,546	SRO15-3108	ribosomal:RiPP:Lanthipeptide	100%

BGC0000554 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 6,546 nt. (total: 6,546 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 6,547
Label		BGC0000554

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554	1.00	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002703	0.32	RiPP	archalan α	Halorussus salinus
BGC0002005	0.25	RiPP	RaxX	Xanthomonas oryzae pv. oryzae
BGC0001555	0.24	RiPP	colicin V	Escherichia coli chi7122
BGC0000588	0.24	RiPP	microcin L	Escherichia coli
BGC0000590	0.23	RiPP	microcin N	Escherichia coli
BGC0002698	0.23	RiPP	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000500	0.22	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001210	0.20	RiPP	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626	0.19	RiPP	thuricin	Bacillus thuringiensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554	1.00	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002703	0.65	RiPP	archalan α	Halorussus salinus
BGC0002005	0.58	RiPP	RaxX	Xanthomonas oryzae pv. oryzae
BGC0001555	0.57	RiPP	colicin V	Escherichia coli chi7122
BGC0000588	0.57	RiPP	microcin L	Escherichia coli
BGC0000590	0.57	RiPP	microcin N	Escherichia coli
BGC0002698	0.56	RiPP	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000500	0.54	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001210	0.52	RiPP	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626	0.51	RiPP	thuricin	Bacillus thuringiensis

Similar known gene clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for SSGG_RS13155

SSGG_RS13165

Leader:

MNLVRAWKDPEYRATLSEAPANPAGLVELADDQLDGVAGG

Core:

TTWACATVTLTVTVCSPTGTLCGSCSMGTRGCC

Core with dehydrations:

DhbDhbWACysADhbVDhbLDhbVDhbVCysDhaPDhbGDhbLCysGDhaCysDhaMGDhbRGCysCys

antiSMASH-DB 4.0 matches for SSGG_RS13165

100.0% NZ_DS999644.1and 2 others:

NZ_LACR01000025.1 Lanthipeptides: YW5_RS27795_lanthipeptideNZ_ML123034.1 Lanthipeptides: EES43_RS16615_lanthipeptide

Lanthipeptides: SSGG_RS13165_lanthipeptide

TTWACATVTLTVTVCSPTGTLCGSCSMGTRGCC

97.0% NZ_BMTW01000001.1and 1 other:

NZ_KZ268499.1 Lanthipeptides: CE422_RS19980_lanthipeptide

Lanthipeptides: IE134_RS03420_lanthipeptide

TTWACATVTLTVTVCSPTGTLCGSCSMGTRGCC

TTWACAT+TLTVTVCSPTGTLCGSCSMGTRGCC

TTWACATITLTVTVCSPTGTLCGSCSMGTRGCC

84.8% NZ_CP070496.1: Lanthipeptides: JQS30_RS16095_lanthipeptide

TTWACATVTLTVTVCSPTGTLCGSCSMGTRGCC

TTW CATVTLTVTVCSPT T+CGSCS GT GCC

TTWGCATVTLTVTVCSPTNTMCGSCSWGTSGCC

with 17 more sequence matches

80.0% NZ_FNAD01000024.1: Lanthipeptides: BLQ63_RS26045_lanthipeptide

TTWAC--ATVTLTVTVCSPTGTLCGSCSMGTRGCC

+TW C AT+ LTVTVCSPTGTLCGSC MGTRGCC

STWGCVTATIALTVTVCSPTGTLCGSCQMGTRGCC

57.9% NZ_CP013979.1: Lanthipeptides: allorf_0343557_0343787_lanthipeptide

TTWACATVTLTVTV----CSPTGTLCGSCSMGTRGCC

T WACATV++ V + CSP GT CGSC+ GT GCC

TGWACATVSIGVGISLAWCSPGGTFCGSCTFGTSGCC

47.1% NZ_CP014228.1: Lanthipeptides: AXF14_RS11840_lanthipeptide

ATVTLTVTVCSPTGTLCGSCSMGTRGCC

A V TVT C L GSC +GTRGCC

AFVVTTVTACWNDTALWGSCRLGTRGCC

45.9% NZ_LR027842.1: Lanthipeptides: E0E39_RS01490_lanthipeptide

CSPTGTLCGSCSMGTRGCC

CSP GTLCGSC MGTRGCC

CSPDGTLCGSCQMGTRGCC

39.4% NZ_BNAY01000019.1: Lanthipeptides: IE302_RS42045_lanthipeptide

TTWACATVTLTVT--VCSPTGTLCGSCSMGTRGCC

+T C T+ +TV+ VC PT + G+ GCC

STIPCVTLPITVSAAVCVPTK------NFGSIGCC

32.4% NZ_CP063989.1: Lanthipeptides: ID810_RS00800_lanthipeptide

LCGSCSMGTRGCC

L GSC MGTRGCC

LWGSCRMGTRGCC

32.4% NZ_GL405260.1: Lanthipeptides: allorf_2499753_2499935_lanthipeptide

VTLTVTVCSPTGTLCGSCSMGTRGCC

+ T+T C + GSC +GTR CC

IIATLTQCFNDTLVWGSCRLGTRACC

27.3% NZ_JABBGE010000004.1and 1 other:

NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13570_lanthipeptide

Lanthipeptides: HHL19_RS13570_lanthipeptide

TTWACATVTLTVTVCSPTG

TTW+CA VT T+ S +

TTWSCAVVTAVATLVSASA

24.2% NZ_AP025343.1: Lanthipeptides: allorf_1820803_1820973_lanthipeptide

CSPTGTLCGSC

C+PT TLC SC

CTPTATLCTSC

24.2% NZ_CP011114.1: Lanthipeptides: VK70_RS27255_lanthipeptide

CSPTGTLCGSCSMG

C+PT TLC SC+

CNPTATLCTSCAFN

24.2% NZ_CP013023.1: Lanthipeptides: allorf_0505345_0505512_lanthipeptide

CSPTGTLCGSC

C+PT TLC SC

CNPTATLCTSC

24.2% NZ_LIPD01000006.1: Lanthipeptides: AMK13_RS18270_lanthipeptide

VCSPTGTLCGSCSMGTRGCC

+C+ T CG+C + GCC

ICTTNQTGCGTCGSFSFGCC

23.8% NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS09415_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS29345_lanthipeptide

Lanthipeptides: IEY56_RS09415_lanthipeptide

TTWACATVTLTVTVCSPT

T W CATVTL PT

TAWVCATVTLATAAICPT

22.5% NZ_CP070496.1: Lanthipeptides: allorf_3787373_3787519_lanthipeptide

TWACATVTLTVTVCSPTGTLCGSCSMGTRG

+W + G L G CS TRG

SWNAPRARGDEPYRNIAGHLAGECSPRTRG

21.4% NZ_PYAS01000021.1: Lanthipeptides: allorf_14749_14949_lanthipeptide

TWACATVTLTVTVCSPTGTLCGSCSMG

+ C T T+T+C+ CG+C+ G

SGGCNTANSTITLCTSNPAGCGTCTSG

19.6% NZ_AKXV01000031.1and 3 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS44045_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS30550_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS30550_lanthipeptide

Lanthipeptides: Y19_RS44045_lanthipeptide

TTWACATVTLTVTVCSPTG

TTW+CA VT T+ S +

TTWSCAIVTAVATLVSASA

17.6% NZ_CP034550.1and 1 other:

NZ_FWXV01000001.1 Lanthipeptides: B9C43_RS03005_lanthipeptide

Lanthipeptides: EKG83_RS30035_lanthipeptide

TVTVCSPTGTLCGSC

+ C+P G+ C SC

DIVACNPPGSRCSSC

SSGG_RS13160

Leader:

MDIVRSWKDADYRLSLGSEAPAHPSGEGLTAITDEELTEINGA

Core:

GSGVLGTLGCCSCLPWYSGWTVCGLACNPGKPCKN

Core with dehydrations:

GDhaGVLGDhbLGCysCysDhaCysLPWYDhaGWDhbVCysGLACysNPGKPCysKN

antiSMASH-DB 4.0 matches for SSGG_RS13160

100.0% NZ_DS999644.1and 1 other:

NZ_LACR01000025.1 Lanthipeptides: YW5_RS27800_lanthipeptide

Lanthipeptides: SSGG_RS13160_lanthipeptide

GSGVLGTLGCCSCLPWYSGWTVCGLACNPGKPCKN

60.0% NZ_FNAD01000024.1: Lanthipeptides: BLQ63_RS26050_lanthipeptide

GSGVLGTLGCCSCLPWYSGWTVCGLACNPGKPCK

G+ +GT GCC CLPWYSGWTVCG C+P C

GTQHMGTFGCCWCLPWYSGWTVCGSLCSPKYVCD

57.1% NZ_CP013979.1: Lanthipeptides: ATC03_RS01475_lanthipeptide

GSGVLGTLGCCSCLPWYSGWTVCGLACNPGKPCK

G+ LGT GCC C+PW+SG+TVCG C G CK

GTNPLGTFGCCWCVPWWSGFTVCGAVC--GTVCK

with 9 more sequence matches

57.1% NZ_LR027842.1: Lanthipeptides: E0E39_RS01495_lanthipeptide

GSGVLGTLGCCSCLPWYSGWTVCGLACN

G+G++GT GCC C+PWYSGWTVCGL C+

GTGLVGTFGCCWCVPWYSGWTVCGLVCS

54.3% NZ_CP014228.1: Lanthipeptides: AXF14_RS11835_lanthipeptide

GSGVLGTLGCCSCLPWYSGWTVCGLACNPG

GSG + T GCC C+PWYS +T CGLAC+ G

GSGWMYTFGCCWCVPWYSSFTKCGLACSQG

51.4% NZ_CP063989.1: Lanthipeptides: ID810_RS00795_lanthipeptide

GSGVLGTLGCCSCLPWYSGWTVCGLACNPG

GSG + T GCC CLPWYS T CG C+ G

GSGWVYTFGCCWCLPWYSSLTKCGAICSQG

51.4% NZ_GL405260.1: Lanthipeptides: HMPREF0580_RS12195_lanthipeptide

GSGVLGTLGCCSCLPWYSGWTVCGLACNP

GS TLGCC CLPWYS WT CG+ C+

GSAAFKTLGCCWCLPWYSSWTKCGVVCSE

25.7% NC_011071.1and 1 other:

NZ_CP090423.1 Lanthipeptides: allorf_0839606_0839731_lanthipeptide

Lanthipeptides: SMAL_RS21270_lanthipeptide

CCSCLPWYSGWTVCGLACNPGKP

C CL WYS GL + G

CVVCLSWYSS----GLGIDEGSD

22.9% NZ_JACDUR010000006.1and 2 others:

NZ_JPMW01000001.1 Lanthipeptides: EV45_RS41010_lanthipeptideNZ_JPMW01000001.1 Lanthipeptides: EV45_RS41005_lanthipeptide

Lanthipeptides: HNR30_RS31115_lanthipeptide

GWTVCGLACNPGKP

G T+ L CN GKP

GSTLTALTCNSGKP

20.0% NZ_CP017717.1and 2 others:

NZ_FNDJ01000002.1 Lanthipeptides: BLS95_RS05705_lanthipeptideNZ_FNVT01000002.1 Lanthipeptides: C4V41_RS07345_lanthipeptide

Lanthipeptides: BKM31_RS59280_lanthipeptide

GWTVCGLACNPGKP

G T+ L+C+ GKP

GSTLTVLSCHSGKP

20.0% NZ_JACHIN010000017.1: Lanthipeptides: HNR40_RS44190_lanthipeptide

GWTVCGLACNPGKP

G T+ L C+ GKP

GSTLTVLTCHSGKP

19.1% NZ_CP011505.1: Lanthipeptides: allorf_0568066_0568302_lanthipeptide

GLACNPGKPCKN

G AC PGKPC+N

GSAC-PGKPCRN

MIBiG 3.1 matches for SSGG_RS13160

14.3% BGC0001155 (AGY49587.1): Thiopeptide: GE2270

CCSCLP

CCSC P

CCSCSP

11.4% BGC0002110 (QKV49893.1): Lanthipeptide: birimositide

GWTVCGLACNPG

GW C P

GWCTLTKECQPN

8.6% BGC0000566 (SPy_0738): LAP: streptolysin S

NPGK

PGK

TPGK

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

SSGG_RS13165 - Class II

Cleavage pHMM score: 0.40

RODEO score: 0

Monoisotopic mass: 3054.4 Da

Molecular weight: 3056.6 Da

Number of bridges: 6

Alternative weights: (assuming N unmodified Ser/Thr residues); 3074.6 Da N = 1; 3092.6 Da N = 2; 3110.6 Da N = 3; 3128.7 Da N = 4; 3146.7 Da N = 5; 3164.7 Da N = 6

SSGG_RS13160 - Class II

Cleavage pHMM score: 3.00

RODEO score: 0

Monoisotopic mass: 3440.6 Da

Molecular weight: 3443.0 Da

Number of bridges: 5