BGC0000554 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000554 (Streptomyces filamentosus NRRL 15998)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	1	23,315	High	SRO15-3108	ribosomal:RiPP:Lanthipeptide

BGC0000554 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 23,315 nt. (total: 23,315 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 23,316
Label		BGC0000554

Tailoring functions

Lyases: cyclase

SSGG_RS13155: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	1.00	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002703.2	0.51	ribosomal	archalan α	Halorussus salinus
BGC0002698.2	0.48	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001555.4	0.47	ribosomal	colicin V	Escherichia coli chi7122
BGC0002005.2	0.47	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000516.4	0.47	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000588.5	0.46	ribosomal	microcin L	Escherichia coli
BGC0000590.5	0.46	ribosomal	microcin N	Escherichia coli
BGC0000527.5	0.46	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000500.5	0.45	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	1.00	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002703.2	0.51	ribosomal	archalan α	Halorussus salinus
BGC0002698.2	0.48	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001555.4	0.47	ribosomal	colicin V	Escherichia coli chi7122
BGC0002005.2	0.47	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000516.4	0.47	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000588.5	0.46	ribosomal	microcin L	Escherichia coli
BGC0000590.5	0.46	ribosomal	microcin N	Escherichia coli
BGC0000527.5	0.46	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000500.5	0.45	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for SSGG_RS13155

SSGG_RS13165

Leader:

MNLVRAWKDPEYRATLSEAPANPAGLVELADDQLDGVAGG

Core:

TTWACATVTLTVTVCSPTGTLCGSCSMGTRGCC

Core with dehydrations:

DhbDhbWACysADhbVDhbLDhbVDhbVCysDhaPDhbGDhbLCysGDhaCysDhaMGDhbRGCysCys

antiSMASH-DB 4.0 matches for SSGG_RS13165

100.0%

NZ_DS999644.1and 2 others:

NZ_LACR01000025.1 Lanthipeptides: YW5_RS27795_lanthipeptideNZ_ML123034.1 Lanthipeptides: EES43_RS16615_lanthipeptide

Lanthipeptides: SSGG_RS13165_lanthipeptide

TTWACATVTLTVTVCSPTGTLCGSCSMGTRGCC

97.0%

NZ_BMTW01000001.1and 1 other:

NZ_KZ268499.1 Lanthipeptides: CE422_RS19980_lanthipeptide

Lanthipeptides: IE134_RS03420_lanthipeptide

TTWACATVTLTVTVCSPTGTLCGSCSMGTRGCC

TTWACAT+TLTVTVCSPTGTLCGSCSMGTRGCC

TTWACATITLTVTVCSPTGTLCGSCSMGTRGCC

84.8%

NZ_CP070496.1:

Lanthipeptides: JQS30_RS16095_lanthipeptide

TTWACATVTLTVTVCSPTGTLCGSCSMGTRGCC

TTW CATVTLTVTVCSPT T+CGSCS GT GCC

TTWGCATVTLTVTVCSPTNTMCGSCSWGTSGCC

with 17 more sequence matches

Only the first 10 are displayed here.

80.0%

NZ_FNAD01000024.1:

Lanthipeptides: BLQ63_RS26045_lanthipeptide

TTWAC--ATVTLTVTVCSPTGTLCGSCSMGTRGCC

+TW C AT+ LTVTVCSPTGTLCGSC MGTRGCC

STWGCVTATIALTVTVCSPTGTLCGSCQMGTRGCC

57.9%

NZ_CP013979.1:

Lanthipeptides: allorf_0343557_0343787_lanthipeptide

TTWACATVTLTVTV----CSPTGTLCGSCSMGTRGCC

T WACATV++ V + CSP GT CGSC+ GT GCC

TGWACATVSIGVGISLAWCSPGGTFCGSCTFGTSGCC

47.1%

NZ_CP014228.1:

Lanthipeptides: AXF14_RS11840_lanthipeptide

ATVTLTVTVCSPTGTLCGSCSMGTRGCC

A V TVT C L GSC +GTRGCC

AFVVTTVTACWNDTALWGSCRLGTRGCC

45.9%

NZ_LR027842.1:

Lanthipeptides: E0E39_RS01490_lanthipeptide

CSPTGTLCGSCSMGTRGCC

CSP GTLCGSC MGTRGCC

CSPDGTLCGSCQMGTRGCC

39.4%

NZ_BNAY01000019.1:

Lanthipeptides: IE302_RS42045_lanthipeptide

TTWACATVTLTVT--VCSPTGTLCGSCSMGTRGCC

+T C T+ +TV+ VC PT + G+ GCC

STIPCVTLPITVSAAVCVPTK------NFGSIGCC

32.4%

NZ_CP063989.1:

Lanthipeptides: ID810_RS00800_lanthipeptide

LCGSCSMGTRGCC

L GSC MGTRGCC

LWGSCRMGTRGCC

32.4%

NZ_GL405260.1:

Lanthipeptides: allorf_2499753_2499935_lanthipeptide

VTLTVTVCSPTGTLCGSCSMGTRGCC

+ T+T C + GSC +GTR CC

IIATLTQCFNDTLVWGSCRLGTRACC

27.3%

NZ_JABBGE010000004.1and 1 other:

NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13570_lanthipeptide

Lanthipeptides: HHL19_RS13570_lanthipeptide

TTWACATVTLTVTVCSPTG

TTW+CA VT T+ S +

TTWSCAVVTAVATLVSASA

24.2%

NZ_AP025343.1:

Lanthipeptides: allorf_1820803_1820973_lanthipeptide

CSPTGTLCGSC

C+PT TLC SC

CTPTATLCTSC

24.2%

NZ_CP011114.1:

Lanthipeptides: VK70_RS27255_lanthipeptide

CSPTGTLCGSCSMG

C+PT TLC SC+

CNPTATLCTSCAFN

SSGG_RS13160

Leader:

MDIVRSWKDADYRLSLGSEAPAHPSGEGLTAITDEELTEINGA

Core:

GSGVLGTLGCCSCLPWYSGWTVCGLACNPGKPCKN

Core with dehydrations:

GDhaGVLGDhbLGCysCysDhaCysLPWYDhaGWDhbVCysGLACysNPGKPCysKN

antiSMASH-DB 4.0 matches for SSGG_RS13160

100.0%

NZ_DS999644.1and 1 other:

NZ_LACR01000025.1 Lanthipeptides: YW5_RS27800_lanthipeptide

Lanthipeptides: SSGG_RS13160_lanthipeptide

GSGVLGTLGCCSCLPWYSGWTVCGLACNPGKPCKN

60.0%

NZ_FNAD01000024.1:

Lanthipeptides: BLQ63_RS26050_lanthipeptide

GSGVLGTLGCCSCLPWYSGWTVCGLACNPGKPCK

G+ +GT GCC CLPWYSGWTVCG C+P C

GTQHMGTFGCCWCLPWYSGWTVCGSLCSPKYVCD

57.1%

NZ_CP013979.1:

Lanthipeptides: ATC03_RS01475_lanthipeptide

GSGVLGTLGCCSCLPWYSGWTVCGLACNPGKPCK

G+ LGT GCC C+PW+SG+TVCG C G CK

GTNPLGTFGCCWCVPWWSGFTVCGAVC--GTVCK

with 9 more sequence matches

57.1%

NZ_LR027842.1:

Lanthipeptides: E0E39_RS01495_lanthipeptide

GSGVLGTLGCCSCLPWYSGWTVCGLACN

G+G++GT GCC C+PWYSGWTVCGL C+

GTGLVGTFGCCWCVPWYSGWTVCGLVCS

54.3%

NZ_CP014228.1:

Lanthipeptides: AXF14_RS11835_lanthipeptide

GSGVLGTLGCCSCLPWYSGWTVCGLACNPG

GSG + T GCC C+PWYS +T CGLAC+ G

GSGWMYTFGCCWCVPWYSSFTKCGLACSQG

51.4%

NZ_CP063989.1:

Lanthipeptides: ID810_RS00795_lanthipeptide

GSGVLGTLGCCSCLPWYSGWTVCGLACNPG

GSG + T GCC CLPWYS T CG C+ G

GSGWVYTFGCCWCLPWYSSLTKCGAICSQG

51.4%

NZ_GL405260.1:

Lanthipeptides: HMPREF0580_RS12195_lanthipeptide

GSGVLGTLGCCSCLPWYSGWTVCGLACNP

GS TLGCC CLPWYS WT CG+ C+

GSAAFKTLGCCWCLPWYSSWTKCGVVCSE

25.7%

NC_011071.1and 1 other:

NZ_CP090423.1 Lanthipeptides: allorf_0839606_0839731_lanthipeptide

Lanthipeptides: SMAL_RS21270_lanthipeptide

CCSCLPWYSGWTVCGLACNPGKP

C CL WYS GL + G

CVVCLSWYSS----GLGIDEGSD

22.9%

NZ_JACDUR010000006.1and 2 others:

NZ_JPMW01000001.1 Lanthipeptides: EV45_RS41010_lanthipeptideNZ_JPMW01000001.1 Lanthipeptides: EV45_RS41005_lanthipeptide

Lanthipeptides: HNR30_RS31115_lanthipeptide

GWTVCGLACNPGKP

G T+ L CN GKP

GSTLTALTCNSGKP

20.0%

NZ_CP017717.1and 2 others:

NZ_FNDJ01000002.1 Lanthipeptides: BLS95_RS05705_lanthipeptideNZ_FNVT01000002.1 Lanthipeptides: C4V41_RS07345_lanthipeptide

Lanthipeptides: BKM31_RS59280_lanthipeptide

GWTVCGLACNPGKP

G T+ L+C+ GKP

GSTLTVLSCHSGKP

20.0%

NZ_JACHIN010000017.1:

Lanthipeptides: HNR40_RS44190_lanthipeptide

GWTVCGLACNPGKP

G T+ L C+ GKP

GSTLTVLTCHSGKP

19.1%

NZ_CP011505.1:

Lanthipeptides: allorf_0568066_0568302_lanthipeptide

GLACNPGKPCKN

G AC PGKPC+N

GSAC-PGKPCRN

MIBiG 4.0 matches for SSGG_RS13160

14.3%

BGC0001155.5 (AGY49587.1):

Thiopeptide: GE2270

CCSCLP

CCSC P

CCSCSP

11.4%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

GWTVCGLACNPG

GW C P

GWCTLTKECQPN

allorf_02447_02632

Leader:

MRLPISAGRERWAGVRGAIGVLGG

Core:

GRCGVAGRWGSRAVRAVLVRRIQDTSSRVRAILHNWN

Core with dehydrations:

GRCysGVAGRWGDhaRAVRAVLVRRIQDDhbDhaDhaRVRAILHNWN

antiSMASH-DB 4.0 matches for allorf_02447_02632

20.0%

NZ_CP045702.1:

Lanthipeptides: allorf_7127338_7127547_lanthipeptide

CGVAGRWGSRAVRA

CG GRW R RA

CGTGGRWAGRWGRA

13.5%

NZ_AXWW01000026.1:

Lanthipeptides: allorf_096938_097069_lanthipeptide

RCGVAGRWGS

CG++ RW S

ECGLSARWSS

allorf_06238_06378

Leader:

MWCTGRTRTRRARAAAA

Core:

RCAAVRSRAPRRRRRPRRRPCRGRRRRRR

Core with dehydrations:

RCysAAVRDhaRAPRRRRRPRRRPCysRGRRRRRR

antiSMASH-DB 4.0 matches for allorf_06238_06378

19.6%

NZ_JACSCH020000010.1:

Lanthipeptides: allorf_087898_088110_lanthipeptide

APRRRRRPRRRPCRG

+P R RRP RPC G

SPGRYRRPGFRPCTG

17.5%

NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: allorf_335018_335257_lanthipeptide

Lanthipeptides: allorf_335018_335257_lanthipeptide

RCAAVRSRAPRRRRRP

RCAA RAPR RRP

RCAAAVRRAPRTDRRP

allorf_08265_08360

Leader:

MCGSVRCRRRAAHGS

Core:

ASVAPRCPAAWRCHAG

Core with dehydrations:

ADhaVAPRCysPAAWRCysHAG

antiSMASH-DB 4.0 matches for allorf_08265_08360

18.2%

NZ_CP096658.1:

Lanthipeptides: allorf_3189783_3190004_lanthipeptide

RCPAAWR

RCPAA+R

RCPAAFR

13.8%

NZ_LR027842.1:

Lanthipeptides: E0E39_RS15855_lanthipeptide

SVAPRCPAAWRCHA

++ C +W CH

TIGAVCTVSWECHG

9.1%

NC_017030.1:

Lanthipeptides: allorf_05055123_05055350_lanthipeptide

SVAPRCPAAW

V P PAAW

DVGPEVPAAW

MIBiG 4.0 matches for allorf_08265_08360

14.8%

BGC0002144.3 (RCCGEPOP_RS37510):

LAP: phazolicin

RCPAAWRC

RC ++ RC

RCDSSSRC

9.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

PAAWRCH

PAA CH

PAAPACH

allorf_08267_08479

Leader:

MRERPLSKTGSSRLRFGRSALSSSMAM

Core:

PRRMSSALLTPVADDSASSRTSNSSGRYTVVFIMLPNLPPCPT

Core with dehydrations:

PRRMDhaDhaALLDhbPVADDDhaADhaDhaRDhbDhaNDhaDhaGRYDhbVVFIMLPNLPPCysPDhb

antiSMASH-DB 4.0 matches for allorf_08267_08479

14.0%

NZ_CP011129.1:

Lanthipeptides: allorf_3813449_3813634_lanthipeptide

LPNLPPC

LP LPPC

LPGLPPC

14.0%

NZ_JAELVF020000001.1:

Lanthipeptides: allorf_1254884_1255084_lanthipeptide

TSNSSGRYTVVFIMLPNLPPC

+S G + ++ + N PPC

SSEPGGAWGEPYVWVVNRPPC

allorf_08909_09118

Leader:

MPLTHRASRCPWRRPCTPASGPPGRRRRSCAPGRGARRRRARWPWSTPRRFRRYGCGPGRSSSATG

Core:

PCS

Core with dehydrations:

PCysDha

allorf_18558_18740

Leader:

MASSRSQLSAAVRMASIPGG

Core:

RSSPRSSANSFWQRLTADSVLAVSPCRQCTAASSSHRCCR

Core with dehydrations:

RDhaDhaPRDhaDhaANDhaFWQRLDhbADDhaVLAVDhaPCysRQCysDhbAADhaDhaDhaHRCysCysR

antiSMASH-DB 4.0 matches for allorf_18558_18740

22.5%

NZ_AZVD01000036.1and 3 others:

NZ_KB896392.1 Lanthipeptides: C576_RS27880_lanthipeptideNZ_KB898432.1 Lanthipeptides: D462_RS1000000129050_lanthipeptideNZ_KB913036.1 Lanthipeptides: A39M_RS0105590_lanthipeptide

Lanthipeptides: K389_RS0119060_lanthipeptide

QRLTADSVLAVSPCRQCTAASSSHRCC

Q +TA +V + C CT + CC

QEITATAVANWTYCSACTGSGPGTHCC

17.0%

NZ_CP093340.1:

Lanthipeptides: MNO14_RS04685_lanthipeptide

LTADSVLAVSPCRQCTAASSSHRC

+T S L ++ C CTA+ +H C

MTDKSFLLLTQCSSCTASIPAHCC

15.1%

NZ_JAGGOV010000059.1and 1 other:

NZ_JAGGOV010000059.1 Lanthipeptides: allorf_076869_077090_lanthipeptide

Lanthipeptides: allorf_076869_077090_lanthipeptide

PRSSANSFWQRLTADSVLAVSPCRQCTAAS

PR + W+ L + P R+ AA+

PRKLGGAAWETLRLRYGSGMGPVRRGRAAA

allorf_18843_19067

Leader:

MLSPAVWELNHRVGG

Core:

RSCPKGPFHSPTASSRASTADSWDPSVNDFRPRSTAEVNRGRSNSSAAISSPYPHWPPR

Core with dehydrations:

RDhaCysPKGPFHDhaPDhbADhaDhaRADhaDhbADDhaWDPDhaVNDFRPRDhaDhbAEVNRGRDhaNDhaDhaAAIDhaDhaPYPHWPPR

MIBiG 4.0 matches for allorf_18843_19067

8.5%

BGC0000503.5 (cinA):

Lanthipeptide: cinnamycin

RSCPKGPF

+SC GPF

QSCSFGPF

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

SSGG_RS13165 - Class II

Cleavage pHMM score: 0.40

RODEO score: 0

Monoisotopic mass: 3054.4 Da

Molecular weight: 3056.6 Da

Number of bridges: 6

Alternative weights: (assuming N unmodified Ser/Thr residues); 3074.6 Da N = 1; 3092.6 Da N = 2; 3110.6 Da N = 3; 3128.7 Da N = 4; 3146.7 Da N = 5; 3164.7 Da N = 6

SSGG_RS13160 - Class II

Cleavage pHMM score: 3.00

RODEO score: 0

Monoisotopic mass: 3440.6 Da

Molecular weight: 3443.0 Da

Number of bridges: 5

allorf_02447_02632 - Class II

Cleavage pHMM score: -4.90

RODEO score: 0

Monoisotopic mass: 4100.3 Da

Molecular weight: 4102.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4120.7 Da N = 1; 4138.7 Da N = 2; 4156.7 Da N = 3

allorf_06238_06378 - Class II

Cleavage pHMM score: -5.80

RODEO score: 0

Monoisotopic mass: 3763.2 Da

Molecular weight: 3765.5 Da

Number of bridges: 1

allorf_08265_08360 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 1633.8 Da

Molecular weight: 1634.9 Da

Number of bridges: 1

allorf_08267_08479 - Class II

Cleavage pHMM score: -6.20

RODEO score: 0

Monoisotopic mass: 4375.3 Da

Molecular weight: 4378.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4396.0 Da N = 1; 4414.0 Da N = 2; 4432.0 Da N = 3; 4450.1 Da N = 4; 4468.1 Da N = 5; 4486.1 Da N = 6; 4504.1 Da N = 7; 4522.1 Da N = 8; 4540.2 Da N = 9; 4558.2 Da N = 10; 4576.2 Da N = 11

allorf_08909_09118 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 287.1 Da

Molecular weight: 287.3 Da

Number of bridges: 1

allorf_18558_18740 - Class II

Cleavage pHMM score: 0.50

RODEO score: 0

Monoisotopic mass: 4152.1 Da

Molecular weight: 4154.6 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4172.6 Da N = 1; 4190.7 Da N = 2; 4208.7 Da N = 3; 4226.7 Da N = 4; 4244.7 Da N = 5; 4262.7 Da N = 6; 4280.8 Da N = 7; 4298.8 Da N = 8

allorf_18843_19067 - Class II

Cleavage pHMM score: -3.40

RODEO score: 0

Monoisotopic mass: 6133.1 Da

Molecular weight: 6136.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 6154.6 Da N = 1; 6172.6 Da N = 2; 6190.6 Da N = 3; 6208.6 Da N = 4; 6226.7 Da N = 5; 6244.7 Da N = 6; 6262.7 Da N = 7; 6280.7 Da N = 8; 6298.7 Da N = 9; 6316.8 Da N = 10; 6334.8 Da N = 11; 6352.8 Da N = 12; 6370.8 Da N = 13; 6388.8 Da N = 14; 6406.9 Da N = 15