Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000560.1:
Cluster 1RiPP111100

BGC0000560, subtilomycin biosynthetic gene cluster from Bacillus subtilis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Subtilomycin
Exact molecular mass: 3234.6 Da (None)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
Lantipeptide (linear)

Gene cluster description

subtilomycin (BGC0000560). Gene Cluster 1. Biosynthetic class = RiPP. GenBank JX912247. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Detailed annotation

subA leader / core peptide, putative Class I
MEKNNIFDLDINKKMESTSEVSAQ - DhbWADhbIGKDhbIVQDhaVKKCRDhbFDhbCGCDhaLGDhaCDhaNCN

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Fergal O'Gara (BIOMERIT Research Centre, School of Microbiology, University College Cork, Ireland)

Literature references

1. Phelan RW et al. (2013) Subtilomycin: a new lantibiotic from Bacillus subtilis strain MMA7 isolated from the marine sponge Haliclona simulans. Mar Drugs 11(6):1878-98. doi: 10.3390/md11061878.
2. Phelan RW et al. (2012) Diversity and bioactive potential of endospore-forming bacteria cultured from the marine sponge Haliclona simulans. J Appl Microbiol 112(1):65-78. doi: 10.1111/j.1365-2672.2011.05173.x.