LOCUS       BGC0000563              5339 bp    DNA     linear   BCT 28-MAR-2011
DEFINITION  Streptomyces venezuelae ATCC 10712 venezuelin gene cluster, complete
            sequence.
ACCESSION   BGC0000563
VERSION     BGC0000563
KEYWORDS    .
SOURCE      Streptomyces venezuelae ATCC 10712
  ORGANISM  Streptomyces venezuelae ATCC 10712
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 13:50:57
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 5339
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..5339
                     /culture_collection="ATCC:10712"
                     /db_xref="taxon:953739"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces venezuelae ATCC 10712"
                     /strain="ATCC 10712"
                     /type_material="type strain of Streptomyces venezuelae"
     protocluster    1..5339
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[185:3038]"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      186..3038
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     cand_cluster    1..5339
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..5339
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000563"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..5339
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-iv"
                     /region_number="1"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            186..3038
                     /gene="venL"
     CDS             186..3038
                     /codon_start=1
                     /gene="venL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 123.9;
                     E-value: 1.4e-37)"
                     /gene_kind="biosynthetic"
                     /product="bifunctional lantibiotic synthetase"
                     /protein_id="AEA03262.1"
                     /sec_met_domain="Pkinase (E-value: 1.2e-18, bitscore: 55.5,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.7e-49, bitscore:
                     155.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSRVTEVELEGLLREALHATGTGARWAVEADEMWCRVTPGAGTR
                     RDQGWKLHLSATAASAPAVLEKALGVLLREESPFKFARSLDQVSALNSRATPLGSSGKF
                     ITVYPRSDAGAARLAHELHGATAGLAGPRILSDQPYAVNSLVHYRYGSFVGRRRLSDDG
                     LLVWFIEDPDGNPVEDQRTGRYAPPPWAVCPFPATVPVVPRAAEGGQGADGSREARGAG
                     APVLLGGRFAVREAIRHTNKGGVYRGSDVRTGALVVIKEARPHVEADASGHDVRDWLRT
                     EARTLERLRGTGLAPEPLALFEHGGHLFLAQQEVPGVALRTWVAEHFRDAGAERYRVDA
                     RAQVGRLVELVAAAHAHGCVLRDFTPGNVMVRPDGELRLIDLELAVLEGDAARPTRVGT
                     PGFSAPERLTGAPVSPTGDYYSLGATACFVLAGKVPNLLPEEPATRAPEQRLAAWLSAC
                     AGPLRLPDGLAEMVLGLMKDAPAERWDPARAREALRRADRDDPVTGKPEDSKGSKGSQA
                     GNVGDAVTVNVGGTVARPLAHPTPGTASAAGADDIAVGVDEAVAGIVDHLLDAMTPADE
                     RRLWPVSTMAGETDSCTVQQGAAGVLGVLTRYWELTGDDRLPELISTAGHWIAHRTDLS
                     STRPGLHFGGRGTAWALYDAGRAVDDDRLMAHATALALAPQQSTPHHDITHGTAGSGVA
                     AVHFWHRTGDPRFAELVVDAADRLTAAGRRDRSGVGWPVPAEAASPEGGTGYLGFAHGT
                     AGIGCFLLAAAAVSGRPEHLDLAVEAGEHLRDQAVLTGEAAHWPARSADPPTAAYWCHG
                     AAGIGTFLVRLWQATGDDRFGELARRATHAVTERASRAALAQCHGLAGNGDFLLDMADA
                     TGDPVHRTAAEDLARLLLGERAHRRAQVVFPNEYGDVSTSWSDGSAGILAFLLRIRHAD
                     PRHWMVQRPVRAAAGLSPAH"
     misc_feature    186..5330
                     /note="venezuelin gene cluster"
     gene            3054..3209
                     /gene="venA"
     CDS             3054..3209
                     /codon_start=1
                     /gene="venA"
                     /product="lantibiotic precursor"
                     /protein_id="AEA03263.1"
                     /transl_table=11
                     /translation="MENHDIELLAHLHALPETDPVGVDGAPFAATCECVGLLTLLNTVC
                     IGISCA"
     gene            3295..4422
                     /gene="venT"
     CDS             3295..4422
                     /codon_start=1
                     /gene="venT"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 217.1; E-value:
                     4.5e-66)"
                     /gene_kind="transport"
                     /product="ABC transporter ATP-binding subunit"
                     /protein_id="AEA03264.1"
                     /transl_table=11
                     /translation="MQPPAGDDDLAPVPLGAAADRTAVAPHVPEPGYAISTRGLVKSYP
                     GPHGTSTLAVRGVDLDVRQGETFAFLGPNGAGKSTTIAVLCALARPTAGQATVAGADVV
                     GRPHEVRRRVGMLFQHSALDGDLTAEQNLFIHARLYGLSRRRARSRTAEVLGTAGLTDR
                     RRSPVRTLSGGMRRRLEIARALLHSPRVLFLDEPTTGLDPHARAQVWDQLRALRDRDGS
                     TLFVTTHYLDEAENCDRIAIIDRGRVVARGTPRALKAAIGDDRVVLRTGDDAVAGRIVC
                     GLVPPDRAVTVDTGGVSLRLPEGSTWIPRLCAALQRHGVAVHAASAAPPTLDDVFFHHT
                     GRSLDAPGTGRPPAGPTPPSVAAPSVSAPDAGGER"
     gene            4419..5330
                     /gene="venH"
     CDS             4419..5330
                     /codon_start=1
                     /gene="venH"
                     /gene_functions="transport (smcogs) SMCOG1065:ABC-2 type
                     transporter (Score: 129.4; E-value: 2.2e-39)"
                     /gene_kind="transport"
                     /product="ABC transporter membrane permease subunit"
                     /protein_id="AEA03265.1"
                     /transl_table=11
                     /translation="MTDLTVKTPRTTGTAVSRVSGDGDGRGSDGGGRGRAARLRRELRA
                     IHALVHRDLLRLAGQRTHTALMLLHPVLYLLVLGGGLAALIPRSSLGVGYQTYLFPGML
                     MMTVQTPAIMVGIRLITDRQSGYVRELLMAPVGRTTLLLGHCAGGTLTATAQGAVLLGL
                     VGTVGLPYDPLLLVLLLGGMVLASFTITALALTLAVSLRRAETFHTLLGVVMMPLLFLS
                     GGFFPLGALPGWAHAVAGANPLALAVDLLRRCIAYQVPGGQAETGVEWDGRQPPLPLEA
                     GLLLSVGAVALFWAARRFNRPD"
ORIGIN
        1 gctccggcgc gcggacctgc cggtttcggg ctccccgagc gcgtttccgc gctgggcgtg
       61 cccgtcggcc gcggcttcgc gctgtgcgct cgccggttca agtgaatgcg ggcggtggtg
      121 tgttggttcc gtgatgcggt cgggaacctt ccggtcagcg gacctcaccg tcgagaagga
      181 cacgcatgac gagccgggtt acggaagtcg agctggaagg actgctccgc gaggcgctgc
      241 acgccacggg tacgggcgcg cgctgggcgg tcgaagcgga cgagatgtgg tgccgtgtca
      301 cgcccggggc ggggacacgg cgggaccagg ggtggaagct ccacctgtcg gcgacggccg
      361 cgtccgcgcc ggccgtcctc gagaaggccc tgggggtgtt gctgcgggag gagtcgccgt
      421 tcaagttcgc ccggtcgctg gatcaggtga gcgcgctcaa ctcccgcgcg acgcccctgg
      481 gaagctcggg caagttcatc accgtctacc cgcgctccga cgccggggcg gcccggctcg
      541 cccacgagct gcacggggcc acggcgggtc ttgccggacc gcggatcctg tccgaccagc
      601 cgtacgccgt gaactcgctg gtgcactacc ggtacggctc gttcgtcggc cggcggcggc
      661 tctcggacga cggcctgctg gtgtggttca tcgaggaccc cgacggcaac cccgtggagg
      721 accagcgcac cggccggtac gccccgcccc cttgggcggt gtgcccgttc cccgccacgg
      781 ttcccgtggt gccccgtgcg gcggaagggg ggcaaggggc ggacggttcg cgagaggcgc
      841 gaggggcagg tgctccggta ctgctcggtg gtcgtttcgc ggtacgggag gcgatccggc
      901 acaccaacaa gggcggcgtc taccggggca gcgacgtccg tacgggcgcc ctcgtcgtga
      961 tcaaggaggc ccggccgcac gtggaggccg acgcctccgg ccacgacgtg cgtgactggc
     1021 tgcgcaccga ggcccggacg ctggagcggc tcaggggcac gggactggct ccggaaccgc
     1081 tggcgctgtt cgagcacggc gggcacctct tcctggccca gcaggaagtg ccgggcgtcg
     1141 ccctgcgcac ctgggtcgcc gagcacttcc gcgacgccgg ggcggagcgc taccgcgtcg
     1201 acgcgcgggc gcaggtcggg cgcctggtgg agctggtcgc ggcggcgcac gcccacggct
     1261 gcgtcctgcg ggacttcaca cccggcaacg tcatggtccg tccggacggc gagctgcgcc
     1321 tcatcgacct cgaactcgcc gtcctggaag gcgacgccgc ccggccgacc cgcgtgggaa
     1381 cccccgggtt cagcgccccc gagcgcctga ccggcgcgcc cgtcagcccg acgggcgact
     1441 actacagcct cggtgccacc gcgtgcttcg tcctggccgg gaaggtaccg aacctgctgc
     1501 ccgaggagcc cgccaccagg gccccggagc agcggctcgc cgcatggctc agcgcctgcg
     1561 cggggccgct tcggctgccg gacggcctcg cggagatggt cctcgggctg atgaaggacg
     1621 cccccgccga gcggtgggac cccgcccggg cgcgcgaggc cctgcgaagg gcggaccgcg
     1681 acgacccggt caccgggaag ccggaggact cgaagggctc gaagggctcg caggccggga
     1741 acgtcggcga cgcggtcacc gtgaacgtcg gcggcacggt ggccaggccc ctggcccacc
     1801 cgacacccgg gaccgcgagc gccgccggcg ccgacgacat cgccgtcggc gtggacgagg
     1861 ccgtcgccgg gatcgtggac catctcctcg acgcgatgac tccggcggac gagcggcggc
     1921 tgtggcccgt gtccaccatg gccggggaga ccgactcctg cacggtgcag cagggcgctg
     1981 ccggtgtcct gggcgtcctc acgcggtact gggaactcac cggtgacgac cggctgcccg
     2041 agctgatctc caccgccggc cactggatcg cgcaccgcac cgatctcagt tccacccgcc
     2101 ccggcctgca cttcggcgga cgcggaacgg cctgggcgct gtacgacgcc gggcgcgccg
     2161 tggacgacga ccggctcatg gcgcacgcga cggccctggc cctggccccg cagcagtcga
     2221 cgccccacca cgacatcacc cacggcaccg cggggagcgg ggtcgccgcc gtccacttct
     2281 ggcaccgcac gggtgatccg cgcttcgccg agctggtcgt cgacgcggcc gaccggctga
     2341 ccgccgcggg ccggcgcgac cgctccgggg tgggctggcc ggtgcccgcc gaagccgcct
     2401 ccccggaggg cggcacgggc tatctcggct tcgcccacgg aacggccggc atcggctgct
     2461 tcctcctcgc cgccgctgcc gtgtccgggc gcccggagca cctggacctc gcggtggagg
     2521 cgggcgagca cctgcgggac caggccgtgc tcaccggcga ggccgcccat tggcccgccc
     2581 ggtcggcgga cccgcccacg gccgcgtact ggtgtcacgg ggcggcgggc atcgggacgt
     2641 tcctcgtccg gctgtggcag gcgaccgggg acgacaggtt cggcgagctc gcccgccgcg
     2701 ccacgcacgc cgtcaccgag cgcgcctccc gcgcggccct ggcccagtgc cacggtctgg
     2761 cgggcaacgg tgacttcctc ctcgacatgg ccgacgccac gggcgacccg gtccaccgga
     2821 ccgcggccga ggacctggcc cggctgctcc tcggcgagcg ggcccaccgc cgagcccagg
     2881 tggtcttccc caacgagtac ggggacgtct cgaccagctg gagcgacgga tccgccggaa
     2941 tcctggcctt cctcctgcgg atccggcacg cagacccccg gcactggatg gtccagcggc
     3001 cggtccgagc ggcagcagga ctgtcgccgg ctcactgaac gaaggagaga accatggaga
     3061 accacgacat cgaactgctc gcccacctcc acgccctccc ggagaccgac cccgtcggcg
     3121 tcgacggggc gccgttcgcg gcgacgtgtg agtgcgtcgg cctgctgacg ctcctcaaca
     3181 cggtctgtat cggcatcagc tgcgcgtagc acgcacccat gcatccggcc ggcggcccgc
     3241 ccgggaagcc gccgaccgga tgttcccccg gaaccgcagg gaggacccga ccgcatgcag
     3301 ccacccgccg gtgacgacga cctcgccccc gtgcccctcg gggcggccgc cgaccgtacg
     3361 gccgtcgcac cgcacgttcc cgagccgggg tacgccatca gcacccgcgg cctggtcaag
     3421 agttacccgg ggccgcacgg gacgagcacc ctcgcggtcc gcggcgtcga cctggacgtg
     3481 cggcagggcg agacgttcgc cttcctcggg cccaacggcg cggggaagtc caccaccatc
     3541 gccgtcctgt gcgccctggc ccggcccacc gccggtcagg ccaccgtcgc gggcgccgac
     3601 gtggtcggcc ggccccacga ggtacggcgg cgcgtcggca tgctgttcca gcacagtgct
     3661 ctggacgggg atctgacggc cgagcagaac ctcttcatcc acgcccgcct gtacgggctg
     3721 tcccggcgcc gggcccgctc gcgcaccgcg gaggttctcg ggacggccgg gctgaccgac
     3781 cggcggcgct cccccgtacg caccctgtcg gggggcatgc ggcggcgcct ggagatcgcc
     3841 cgggccctgc tgcactcgcc ccgcgtgctg ttcctcgacg agccgaccac gggactcgac
     3901 ccgcacgccc gcgcccaggt ctgggaccag ctgcgcgcgc tgcgcgaccg ggacggcagc
     3961 acgctcttcg tcaccaccca ctacctggac gaggcggaga actgcgatcg catcgccatc
     4021 atcgaccgcg gccgcgtggt ggcgcggggc acgccccgag cgctgaaggc ggcgatcggg
     4081 gacgaccggg tcgtcctgcg gaccggcgac gacgcggtgg cgggacggat cgtgtgcggc
     4141 ctggttccgc cggaccgggc tgtcaccgtg gacaccggcg gagtctccct gcggctgccg
     4201 gagggcagca cgtggattcc gcggctgtgc gcggcgctgc aacgccacgg cgtcgccgtg
     4261 cacgccgctt ccgcggcccc gcccacgctc gacgacgtct tcttccacca caccggccgc
     4321 agtctggacg cccccgggac gggccgcccg ccggccggtc ccaccccgcc gtccgtggcc
     4381 gcgccgtccg tgtccgcgcc ggacgcggga ggcgagcgat gaccgacctc acggtgaaga
     4441 ccccccggac cacgggcacg gcggtctcgc gcgtctccgg cgacggcgac ggtcggggct
     4501 ccgacggcgg tggcaggggg cgggcggccc ggctccggcg cgaactgcgc gcgatccacg
     4561 ccctggtcca ccgcgacctg ctgcggctcg cgggccagcg cacccacacg gcgctgatgc
     4621 tgctgcaccc ggtgctctac ctcctcgtcc tgggaggcgg gctcgccgcc ctcatcccgc
     4681 gctcctccct gggcgtcggc taccagacgt atctcttccc cggcatgctg atgatgacgg
     4741 tgcagacccc ggccatcatg gtcggcatcc gtctgatcac cgaccggcag agcggctacg
     4801 tgcgggagct gctcatggcc cccgtcggcc gcaccaccct cctcctgggg cactgcgcgg
     4861 gcggcacgtt gacggccacg gcgcagggcg ccgtgctgct cggcctggtc ggcacggtcg
     4921 gcctgcccta cgacccgctc ctcctggtcc tgctgctggg cgggatggtc ctggcctcgt
     4981 tcaccatcac cgcgctggcc ctgaccctgg ccgtgtccct gcgcagggcg gagacgttcc
     5041 acaccctcct cggcgtggtc atgatgccgc tgctgttcct ctccggcggc ttcttccccc
     5101 tgggggcgct gcccggctgg gcccatgccg tcgccggcgc caacccgctg gccctcgccg
     5161 tggacctgct gcgccggtgc atcgcctacc aagtgcccgg tgggcaggcg gagaccggcg
     5221 tcgagtggga cggccggcag cctccccttc ccctcgaagc gggtctcctc ctctccgtcg
     5281 gcgctgtcgc cctgttctgg gccgcgcgcc gcttcaaccg tcctgactga cgtaccggt
//
