Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000563.1:
Cluster 1RiPP15339

BGC0000563, venezuelin biosynthetic gene cluster from Streptomyces venezuelae. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Venezuelin
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
RiPP subclass:
Lantipeptide (cyclic)
Peptides in this cluster:
RiPP core peptide sequence(s): ATCECVGLLTLLNTVCIGISCA
Leader peptide length: 29
Follower peptide length: -1
Cleavage recognition site sequence(s):
Peptidase(s) involved in precursor cleavage: Unknown
Crosslinks in final product:
2=21 AA (Thioether)
3=7 AA (Thioether)
9=20 AA (Thioether)
13=18 AA (Thioether)

Gene cluster description

venezuelin (BGC0000563). Gene Cluster 1. Biosynthetic class = RiPP. GenBank HQ328852. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Detailed annotation

No core peptides found.

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Enzymatic assays
Contact for this cluster:Xi Zhao (University of Illinois at Urbana-Champaign)

Literature references

1. Goto Y et al. (2010) Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights. PLoS Biol 8(3):e1000339. doi: 10.1371/journal.pbio.1000339.
2. Goto Y et al. (2011) Mechanistic studies of Ser/Thr dehydration catalyzed by a member of the LanL lanthionine synthetase family. Biochemistry 50(5):891-8. doi: 10.1021/bi101750r. Epub 2011 Jan 13.