Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000564.1:
Cluster 1RiPP18634

BGC0000564, clostridiolysin S biosynthetic gene cluster from Clostridium botulinum. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: clostridiolysin S
Molecular activity: Other
Molecular target: Hemoglobin

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
LAP (linear)
Peptides in this cluster:
SAGA
RiPP core peptide sequence(s): VAPGSCCCCSCCCCVSVSVGGGSASTGGGAAAGQGGN
Leader peptide length: -1
Follower peptide length: -1
Peptidase(s) involved in precursor cleavage:

Gene cluster description

clostridiolysin S (BGC0000564). Gene Cluster 1. Biosynthetic class = RiPP. GenBank AM412317, positions 576447-585080. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Alexey Melnik (UCSD)

Literature references

1. Gonzalez DJ et al. (2010) Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum. J Biol Chem 285(36):28220-8. doi: 10.1074/jbc.M110.118554. Epub 2010
2. Peck MW et al. (2011) Clostridium botulinum in the post-genomic era. Food Microbiol 28(2):183-91. doi: 10.1016/j.fm.2010.03.005. Epub 2010