LOCUS       BGC0000566              8290 bp    DNA     linear   BCT 01-APR-2014
DEFINITION  Streptococcus pyogenes M1 GAS, complete genome.
ACCESSION   BGC0000566
VERSION     BGC0000566
KEYWORDS    .
SOURCE      Streptococcus pyogenes M1 GAS
  ORGANISM  Streptococcus pyogenes M1 GAS
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
COMMENT     On Apr 1, 2014 this sequence version replaced AE004092.1.
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 13:51:05
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 598676
            Orig. end    :: 606966
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..162
                     /codon_start=1
                     /gene="sagA"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     TIGR03602"
                     /gene_kind="biosynthetic"
                     /locus_tag="SPy_0738"
                     /note="Best Blastp hit = gb|AAC19115.1| (AF067723)
                     streptolysin S associated protein SAGA [Streptococcus
                     pyogenes] >gi|3283388|gb|AAC25177.1| (AF067649) SagA
                     [Streptococcus pyogenes]"
                     /old_locus_tag="SPy0738"
                     /product="streptolysin S associated protein"
                     /protein_id="AAK33684.1"
                     /sec_met_domain="TIGR03602 (E-value: 9e-32, bitscore: 98.4,
                     seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKFTSNILATSVAETTQVAPGGCCCCCTTCCFSIATGSGNSQGG
                     SGSYTPGK"
     subregion       1..8290
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="ribosomal"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..8290
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..162
                     /gene="sagA"
                     /locus_tag="SPy_0738"
                     /old_locus_tag="SPy0738"
     gene            384..1334
                     /gene="sagB"
                     /locus_tag="SPy_0739"
                     /old_locus_tag="SPy0739"
     CDS             384..1334
                     /codon_start=1
                     /gene="sagB"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_kind="biosynthetic"
                     /locus_tag="SPy_0739"
                     /note="Best Blastp hit = gb|AAC25178.1| (AF067649) SagB
                     [Streptococcus pyogenes]"
                     /old_locus_tag="SPy0739"
                     /product="streptolysin S associated ORF"
                     /protein_id="AAK33685.1"
                     /sec_met_domain="PF00881 (E-value: 5.5e-35, bitscore:
                     110.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFFTKEQQPKENCPPITVEKARQLFEFNTNHLSLSDYHHQTVLK
                     TSKQLVAQHLMPNATDNLSQHFLMNYKANNNYLGFQASIVDFFTDSAVANFSSSYVYES
                     QEKIIRLPKPTKISTALSTCIIKRRSHRQFSDRQMPLQDLSNILYYACGVSSQASIRDG
                     ASDKITLRNCASGGGLYPIHLVFYARNISKLIDGFYEYLPYQHALRCYRHSSEENVRDF
                     AEYGAINAENCNIIIIYVYHYMKNTRKYGNQATAYAFIESGEIAQNIQLTATALTYGSI
                     DIGGYNKEYLQELLDLDGLGEHVIHMTLVGTKESQ"
     gene            1331..2389
                     /gene="sagC"
                     /locus_tag="SPy_0740"
                     /old_locus_tag="SPy0740"
     CDS             1331..2389
                     /codon_start=1
                     /gene="sagC"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     TIGR03603"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytolysin_C_RRE"
                     /gene_kind="biosynthetic"
                     /locus_tag="SPy_0740"
                     /note="Best Blastp hit = gb|AAC25179.2| (AF067649) SagC
                     [Streptococcus pyogenes]"
                     /old_locus_tag="SPy0740"
                     /product="streptolysin S associated ORF"
                     /protein_id="AAK33686.1"
                     /sec_met_domain="Cytolysin_C_RRE (E-value: 7.8e-43,
                     bitscore: 134.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03603 (E-value: 2.1e-142, bitscore:
                     463.6, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYQLNSNVRVVTFQDTFCFRKGIWDFNEAILDLTQEPQNLKIVY
                     QEIVSQLVKGVAIDTETYENTLEPETFANLMEVISGLYYNDMLMLEDDYNLEENVMKIL
                     MGNFRFMAQAGHMVSNDPVLFISDSTYVNESAELLAEQLHLQLQVASDDLKMLIQQTDV
                     SSRLDALEHRRNMNCLSDALCDYQSIIICQERLNIMMLRHLNEVSVAMKKQLVIGFVDG
                     PFLHTCTLNPPHSADFDSLERRVLARLQDSTLYQHFANQVLPATQDVSQAYLPLLNVLM
                     NLVVSEAFIIAQTGSSKFEGRLLSIYLPTLEIQVQDILKMSNSQTQGALAKLKYEDQQI
                     STREIVKKLLDE"
     gene            2409..3767
                     /locus_tag="SPy_0741"
                     /old_locus_tag="SPy0741"
     CDS             2409..3767
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_kind="biosynthetic"
                     /locus_tag="SPy_0741"
                     /note="Best Blastp hit = pir||E64436 conserved hypothetical
                     protein MJ1094 - Methanococcus jannaschii
                     >gi|1499943|gb|AAB99097.1| (U67552) conserved hypothetical
                     protein [Methanococcus jannaschii]"
                     /old_locus_tag="SPy0741"
                     /product="hypothetical protein"
                     /protein_id="AAK33687.1"
                     /sec_met_domain="YcaO (E-value: 3.4e-65, bitscore: 210.1,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 2e-113, bitscore:
                     368.2, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLYYYPSFNHIFDELKSLSGNRTGILNQSQVPVCNHPHDVYLKSI
                     TGQMPDYHKQFIGELSQVSYHIIGYGSYYEEALIKYLGESIERYATVIAGDLLSDRIVY
                     ASYNELKLLHKVMPLEYLQVFTQEQIALSCDLQMMMCDKMVTENDVLGWVKCPMFFEDA
                     EMYVPAQMLCVGYKTNETVGERRIIPGFSTGTASHKTLEAAMCNSLIEYIQIDSMMLSW
                     YTKKPCPKIIVDDPDIEVILEEARLGKDSLYDIIPIDMTVGEDNPLYTFGIILKNKYDE
                     GPYLLFGVQAGLDPKHALLRGIMEASAISYSYYYNLLYQKASLANIECEEPLFLDLDSN
                     VFYYAHPKDQDHKWKAFEPLISGEVLLSDLEDHSGKDKKEDLKTLLAYAKKVSPNAVFL
                     DITPPEALEKGWYVTRVLMPELLEMCIPAFPFANHPRMRQFGGVTNAFVHPMP"
     gene            3742..4413
                     /locus_tag="SPy_0742"
                     /old_locus_tag="SPy0742"
     CDS             3742..4413
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SPy_0742"
                     /note="Best Blastp hit = dbj|BAB04194.1| (AP001508) unknown
                     conserved protein [Bacillus halodurans]"
                     /old_locus_tag="SPy0742"
                     /product="hypothetical protein"
                     /protein_id="AAK33688.1"
                     /sec_met_domain="Abi (E-value: 6e-13, bitscore: 38.4,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLSIQCLNLCFLLVTFCPSIPMQAIFGKEDSGYAFNLIGFLRAT
                     LIYDILALVSIYVLSPQITLSLESIDSKTFFMGLVFCVLIVLIELVFLHGLRCWQKKQW
                     LPATFSFVGTTNDWSKIGYPLLLALFEETIYRFLWFNILAFQWHLPTIIVLIVTSFCYA
                     LNHLLMGKSIFYAKLVTGIIYGSIYMLTSQLWLVVIMHVGGNLLVECLSHLQTKKKKEV
                     T"
     gene            4410..5093
                     /locus_tag="SPy_0743"
                     /old_locus_tag="SPy0743"
     CDS             4410..5093
                     /codon_start=1
                     /locus_tag="SPy_0743"
                     /note="Best Blastp hit = no blast hits"
                     /old_locus_tag="SPy0743"
                     /product="hypothetical protein"
                     /protein_id="AAK33689.1"
                     /transl_table=11
                     /translation="MMLLVLLSFLGLTTLWLTSYRRRCLARWHLQWLVALSYQDFLDVL
                     LSLFQFVVIILVLFFYSATINLGEVLTFLTQTSWHWQILCYLVLYLMAIIEMTLLVLIL
                     IFDVLLQKDSRLLFKKITWLPFRQDKPVLSILLLGTVILVDSLFYLGLLILLGEQSLTS
                     LATLILGYGIVKACRYSGWLNVLLAFCLFTIVGLWAVTATLLYGWLVGAMILTVTYLMI
                     SCKEY"
     gene            5116..6039
                     /locus_tag="SPy_0744"
                     /old_locus_tag="SPy0744"
     CDS             5116..6039
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 215.3; E-value:
                     1.6e-65)"
                     /gene_kind="transport"
                     /locus_tag="SPy_0744"
                     /note="Best Blastp hit = pir||G69803 ABC transporter
                     (ATP-binding protein) homolog yfiL - Bacillus subtilis
                     >gi|1817536|dbj|BAA11402.1| (D78508) YfiL [Bacillus
                     subtilis] >gi|2633155|emb|CAB12660.1| (Z99108) similar to
                     ABC transporter (ATP-binding protein) [Bacillus subtilis]"
                     /old_locus_tag="SPy0744"
                     /product="putative ABC transporter (ATP-binding protein)"
                     /protein_id="AAK33690.1"
                     /transl_table=11
                     /translation="MSFVQLTNVVKSYKNGKKAVNDVSLSIEAGNIYGLLGPNGAGKST
                     LINLILGLIPLSSGKITVLGQSQKTIRKISSQIGYVPQDIAVYPDLTAYENVELFGSLY
                     GLKGAQLKKQVLKSLEFVGLHSQAKQFPSQFSGGMKRRLNIACALVHSPKLIIFDEPTV
                     GIDPQSRNHILESIRLLNKEGATVIYTTHYMEEVEALCDYIFIMDHGQVIEEGPKFELE
                     KRYVANLANQIIVTLTDSRHLELADKPDWSLIEDGEKLMLKIDNSDMTSVVHQLTQANI
                     TFSEIRHNHLNLEEIFLHLTGKKLRD"
     gene            6048..7175
                     /gene="sagH"
                     /locus_tag="SPy_0745"
                     /old_locus_tag="SPy0745"
     CDS             6048..7175
                     /codon_start=1
                     /gene="sagH"
                     /locus_tag="SPy_0745"
                     /note="Best Blastp hit = gb|AAD49330.1|AF163682_1
                     (AF163682) SagH [Streptococcus pyogenes]"
                     /old_locus_tag="SPy0745"
                     /product="ABC transporter (ATP-binding protein) -
                     streptolysin S associated ORF"
                     /protein_id="AAK33691.1"
                     /transl_table=11
                     /translation="MVLFHLIKKESLQIFRNRTALLMMVIFPILMIVILSFAFKSSFNT
                     ATTVPKLTIRYQLEGEKTDYQKNFLAFLKVLNQKLHLETKPSNSLEKDRQRVSEGALTA
                     VLEVKKNQTIKVITNNINQQNADLINMLVKNYVDNAKTYDSIAALYPQQLNHIRKRSVD
                     YVKVSSIQTSKGMTSADYYAISMFTMITFYSMMSAMNLVLSDRQQRITNRIHLTGVSPS
                     FLVFGKLIGAMLATTVQLSLLYIFTRFVLRVNWGTNEWMLIGITASLVYLSVAIGIGLG
                     ISIKNEAFLTVASNTIIPIFAFLGGSYVPLTTLHSSIINQLSNISPIKWVNDSLFYLIF
                     GGQYNPIPVTLIVNISIGTIFIILALIGMRKQVTT"
     gene            7172..8290
                     /locus_tag="SPy_0746"
                     /old_locus_tag="SPy0746"
     CDS             7172..8290
                     /codon_start=1
                     /locus_tag="SPy_0746"
                     /note="Best Blastp hit = pir||A69804 ABC transporter
                     (ATP-binding protein) homolog yfiN - Bacillus subtilis
                     >gi|1817538|dbj|BAA11404.1| (D78508) YfiN [Bacillus
                     subtilis] >gi|2633157|emb|CAB12662.1| (Z99108) similar to
                     ABC transporter (ATP-binding protein) [Bacillus subtilis]"
                     /old_locus_tag="SPy0746"
                     /product="putative ABC transporter (ATP-binding protein)"
                     /protein_id="AAK33692.1"
                     /transl_table=11
                     /translation="MICFIKTLFVKIKRKKTSYVTFFLMPILTTLLALSLSFSNNNQAK
                     IGILDKDNSQISKQFIAQLKQNKKYDIFTKIKKEHIDHYLQDKSLEAVLTIDKGFSDKV
                     LQGKSQKLNIRSIANSEITEWVKAQTNYLLENYNIIGDVALGNEDTFNRILQKNQQLNY
                     DVKQVTLTDRSRSKAVSSTTTGFLLILMLGSTSVIYSGILADKSSQLYHRLMLSNLSRF
                     RYMLSYVCVGFVAFTIQIVIMLSLLKVFNISFFVPTSLLLIIFFLFSLLAIGFGLLIGA
                     ITQNSQQSSQLANLIVMPTSMLAGCLWPLSITPSYMQAIGKLLPQNWVLSAIAIFQSGG
                     TLSQAWPYLLALMGTALALISFSSLLLKPTKL"
ORIGIN
        1 atgttaaaat ttacttcaaa tattttagct actagtgtag ctgaaacaac tcaagttgct
       61 cctggaggct gctgttgctg ctgtactact tgttgcttct caattgctac tggaagtggt
      121 aattctcaag gtggtagcgg aagttatacg ccaggtaaat aatctattta gcatctctat
      181 gtgatagtga tattaaggta atgagtttgc tagcaactaa gttatctttg gtaacttctg
      241 attatagatg aatggcatag aggtgttaga aaacatgaga caaaagtaat cttcttgatg
      301 ctaacgtctc aggtaattag caggtactag atagtacctg ctaattacta tatgtttagt
      361 aaaatgagat aggaaagata gttatgtcat tttttacaaa ggaacaacaa cctaaagaga
      421 attgtccgcc aataactgtt gaaaaagcaa ggcaattgtt tgaatttaat acaaaccact
      481 tgtccttatc ggattaccat catcaaacgg tgctaaaaac gtcaaagcag ctagttgctc
      541 aacatttaat gcctaatgca accgataatc ttagtcaaca ttttttgatg aactataaag
      601 ctaataataa ttatttaggc ttccaagcta gtattgtcga cttttttaca gattctgccg
      661 ttgctaattt ttcaagtagt tacgtttatg aaagtcagga aaagataatt cgtttaccaa
      721 aacctaccaa gatatcaact gctctgtcga catgtattat aaaacgaaga agtcatcgtc
      781 aattttcaga tagacaaatg cctcttcaag atttatcaaa cattctttat tatgcatgtg
      841 gtgttagttc acaagcatca attagagatg gagcatcaga taagattaca ctcagaaact
      901 gtgcttcagg tggaggttta taccctattc atttagtttt ttatgctaga aacatcagta
      961 aattaataga tggtttctat gaatatctac cctatcagca tgcactaagg tgttatcggc
     1021 atagctctga ggaaaacgtt agagattttg cggaatacgg tgctattaat gctgaaaatt
     1081 gtaatattat tattatttat gtctaccatt acatgaaaaa tacacgtaaa tatgggaatc
     1141 aggcgactgc ctatgctttt attgaatcag gagaaatagc ccagaatatt caattgactg
     1201 caactgcctt aacttatgga agtattgata ttggtggtta taataaggaa tatctccaag
     1261 aattattaga tttagatggg ctaggagagc atgtgattca catgacactc gtaggaacta
     1321 aggagtctca atgaaatatc aacttaatag taatgttcgt gtcgtgacat ttcaagatac
     1381 attttgtttt agaaaaggaa tctgggactt taatgaagcc attctagatt tgacacaaga
     1441 acctcaaaat ttaaagatag tttatcaaga aatagtttca cagttggtta agggagtagc
     1501 cattgatact gaaacttatg aaaatacttt agaacctgag acgttcgcta atttaatgga
     1561 agtcatttca ggcttgtatt acaatgatat gctgatgctt gaggatgact acaatcttga
     1621 agaaaatgtc atgaaaattt taatgggtaa tttccgtttt atggcgcaag caggtcatat
     1681 ggtaagcaat gatcctgttt tgtttatcag tgattcgact tatgttaatg aatctgctga
     1741 gttgctagct gaacaactgc atttacaatt gcaagtggct agtgatgact taaaaatgtt
     1801 aattcagcag acagatgtta gttcgcgttt agatgctttg gagcatcgcc gtaacatgaa
     1861 ttgtttatca gatgccttgt gcgattacca aagtattatt atttgtcaag aacgcttgaa
     1921 tattatgatg ttgcgacact tgaatgaagt tagcgtagct atgaaaaaac aattagtgat
     1981 tggttttgta gatggaccat tcttgcacac ttgtactttg aatcctcccc atagtgctga
     2041 ctttgatagc ttagaaagaa gagttttggc acgtttacaa gactcaactc tctatcaaca
     2101 ttttgctaat caggttttac cagccacaca agatgtgagc caggcctatt taccattgtt
     2161 aaatgtttta atgaatttag tcgttagcga agctttcatt attgctcaaa caggtagttc
     2221 taaatttgag ggacgtttat taagcattta cttaccgacg cttgagattc aggtccaaga
     2281 tattttgaaa atgtctaatt cacagacaca aggagctttg gcaaaattaa agtatgagga
     2341 tcagcagata tcaacacgtg agattgttaa aaaactcctt gacgagtaac ctataaggag
     2401 aatctattat gttatactat tatccttctt ttaatcatat ttttgatgaa ttaaaaagtt
     2461 taagtggcaa tcgaacaggt atcttaaatc aatctcaagt tccagtttgc aaccatcctc
     2521 acgatgttta cttaaaaagt attactggcc aaatgccaga ttatcataaa caatttatag
     2581 gtgagttgag tcaagttagt tatcacatta ttggttacgg cagttactat gaagaagcac
     2641 ttatcaagta tttaggagaa agtattgaac gctatgctac tgtaattgcc ggagacttac
     2701 tatcagatcg gattgtctat gcttcttata atgagttaaa actgttacat aaagtgatgc
     2761 ctttagaata cttgcaagtg tttacccaag aacagatcgc attatcttgt gacttgcaaa
     2821 tgatgatgtg cgataaaatg gtaactgaga acgatgtatt gggctgggtt aaatgtccca
     2881 tgttctttga ggacgcagag atgtatgttc cagctcaaat gctttgtgtt gggtataaaa
     2941 caaatgagac tgtaggagaa agacggataa taccaggatt ttctacggga acagcttctc
     3001 acaaaacgtt agaagcggct atgtgcaaca gtttgattga atacatccag atcgattcaa
     3061 tgatgcttag ctggtatact aagaagcctt gccccaagat tattgttgat gatcctgata
     3121 ttgaagtgat tttagaagaa gctagactgg gaaaagacag tctatacgac attattccta
     3181 ttgatatgac tgtaggagaa gataatcctc tttatacgtt tggaatcatt ctcaaaaata
     3241 aatatgatga agggccttac ctcttgtttg gagtgcaggc tgggttagat cctaaacatg
     3301 ctttgctaag agggatcatg gaagcttcag ctattagcta tagttactac tataatcttt
     3361 tatatcaaaa agcttccctt gcaaatattg aatgcgaaga acctttgttt ttagatttag
     3421 atagtaatgt cttctattat gcacatccca aggaccaaga ccataaatgg aaggcctttg
     3481 aacctttgat ttcaggagaa gttctgttaa gtgatttgga agatcattct ggtaaagata
     3541 aaaaagaaga tttgaagact ttattagctt atgctaagaa agtcagtcct aatgctgtct
     3601 ttttagatat tacacctcct gaagctctag aaaaaggctg gtacgtcacg cgagttctga
     3661 tgccagaact tcttgaaatg tgtataccag catttccttt tgctaatcat ccacgaatga
     3721 gacagtttgg aggtgtaaca aatgcctttg tccatccaat gccttaatct ttgttttttg
     3781 ttggtaactt tttgtccttc aattcctatg caagctattt ttggaaagga agatagtggt
     3841 tatgcattta atttaattgg ttttctaaga gcaactctga tttatgacat tttggctttg
     3901 gtaagtattt atgttttgtc acctcaaata accttgtctc ttgaaagtat tgatagtaag
     3961 acgttcttta tgggacttgt attttgcgtc ttgatagtac tgattgaact cgttttctta
     4021 catggtttac gttgttggca aaaaaagcaa tggcttcctg caactttctc gtttgtagga
     4081 acgacaaatg attggtctaa gattggctat cctttattac tagctttatt tgaagagacg
     4141 atttatcgtt ttttgtggtt taatatatta gcttttcaat ggcatttacc aacaattatt
     4201 gttttaattg taactagttt ttgctatgct ttaaatcact tattgatggg gaaatccatt
     4261 ttttatgcta agttggtaac aggcatcatt tatggtagta tttacatgct gactagtcaa
     4321 ttgtggttgg ttgtgataat gcatgtagga ggtaacttgc tagttgagtg tcttagccat
     4381 cttcaaacaa aaaagaagaa ggaggtgaca tgatgctatt ggttttgctg tcgtttttag
     4441 gtctaactac tctttggttg accagttatc gaagacgttg tttggctaga tggcatcttc
     4501 aatggttagt ggccttatcc tatcaagatt ttttagatgt cttactgagt ctgtttcaat
     4561 ttgtcgttat tatacttgtt ttattctttt actcagctac tattaatcta ggagaggttc
     4621 tgaccttttt gacacaaact agctggcatt ggcagattct ttgttattta gtgttatatc
     4681 ttatggccat catagagatg acgcttttag ttttaattct tatctttgat gttttgctcc
     4741 agaaagacag tcgattgctc tttaaaaaaa taacttggct gccttttaga caagataaac
     4801 cagtcttaag tatactttta ctaggcacag ttattctagt agacagtctc ttttatttgg
     4861 gcttgcttat attattagga gaacagtcgc taacaagttt agcaacgctt attttaggtt
     4921 atgggatagt caaggcttgt cgctattcag gttggttaaa tgtactatta gctttttgtc
     4981 ttttcactat agttggacta tgggcagtta cggcaacttt attatatggt tggctagtag
     5041 gtgcgatgat attaacggtg acttatttga tgattagttg caaagagtat tagcaatatt
     5101 aaaaaggagt gatatatgag ttttgtacaa ttaacaaatg ttgtcaagtc ctacaaaaac
     5161 ggcaagaaag ctgtcaatga tgtttccttg tctattgaag caggtaatat ttatggtttg
     5221 ttaggaccaa atggtgctgg taagtctacc ttgattaatc ttatcttagg cttgatccct
     5281 ttgagttccg gtaaaattac tgttttaggg caatcccaaa agactattcg aaaaataagt
     5341 tcgcagatag gttatgttcc tcaagacatt gctgtttatc cagacctaac tgcttatgaa
     5401 aatgtagaac tatttgggtc actttatggc ttaaagggag ctcagcttaa aaaacaagtt
     5461 ctaaaaagtt tagaatttgt ggggctacac tcccaagcta agcagtttcc aagtcaattc
     5521 tcaggaggaa tgaagagacg gttaaatatc gcttgtgcgc tagttcattc acctaaatta
     5581 atcatttttg acgaaccgac tgtagggatt gatcctcaat cacgtaatca tattttagag
     5641 tcgattcgtt tgctaaacaa agaaggtgct acagttattt atacgaccca ttatatggaa
     5701 gaagtagagg ctctttgtga ttatattttt attatggatc atggtcaagt tattgaagaa
     5761 ggacctaaat ttgaactgga aaaacgttac gttgcaaatc tagcaaacca gattattgta
     5821 actctaacag attcacgtca tttggaactg gcagataagc ctgattggtc tttgatagaa
     5881 gatggagaaa aactcatgtt gaagattgat aatagtgata tgacatcagt tgttcatcag
     5941 ctcacacagg ccaatattac ttttagcgag attagacata accatttgaa tttagaagaa
     6001 attttcttac acttaacagg taagaagtta cgagattaga ggttactatg gttttatttc
     6061 atttaatcaa aaaagaaagt ttacagattt ttagaaaccg aacagcctta ttgatgatgg
     6121 tgatttttcc aattttgatg atcgttattt taagttttgc ctttaaatca agttttaata
     6181 ctgcgacaac agtccctaaa ttgaccattc gttaccaatt agagggtgaa aaaacggatt
     6241 accagaaaaa ttttcttgct tttttaaaag ttttaaacca aaaacttcat ttagagacta
     6301 aacctagtaa ttctcttgaa aaagatcgac aaagggtcag tgaaggagcc ttaacggctg
     6361 ttttagaagt gaagaagaat cagaccatta aggttattac taataatatt aatcagcaaa
     6421 atgcagattt gatcaatatg ctagtaaaaa attatgttga taatgctaaa acttatgact
     6481 cgatagcagc tctttatcct caacaattaa atcatatcag aaagcgaagt gtggactatg
     6541 ttaaggtcag ttcaatacag acaagtaaag gaatgacatc agctgattat tatgctattt
     6601 ccatgtttac catgattact ttttatagta tgatgtctgc gatgaacctt gttttgtcag
     6661 atcgtcaaca acggattaca aatcgtattc acttaacagg agtttctcca agttttttgg
     6721 tctttgggaa attaataggt gctatgttag caacaactgt tcaattgagt cttttataca
     6781 tttttacaag gtttgtttta cgagttaatt ggggcactaa tgagtggatg cttattggta
     6841 taacagcctc cttagtctat ctctctgtag ctataggtat cgggctaggt ataagcatta
     6901 aaaatgaggc ttttttaacg gttgcatcca atactattat tcctatattc gcctttttag
     6961 gaggcagtta cgttccattg acaacattac acagctctat tattaatcaa ttgtcgaata
     7021 tatctcctat taaatgggtt aatgatagtt tgttctatct tatttttggt ggtcaatata
     7081 atccgattcc tgtaactttg atcgttaata ttagtatcgg aacaattttt ataatattgg
     7141 cattgatagg tatgagaaag caggtgacga catgatttgt tttataaaaa ctctatttgt
     7201 taagataaag cgcaaaaaaa caagttatgt gacattcttt ttaatgccta ttttaacgac
     7261 acttttggct ttatctttga gtttttcaaa taataatcaa gctaaaattg ggatattaga
     7321 taaagataat agtcagatat ctaaacaatt tattgctcaa ctaaagcaaa acaaaaagta
     7381 cgacattttt accaaaatca aaaaagagca tattgatcac taccttcaag ataaatctct
     7441 agaagcggta ttgactattg acaaagggtt ctcagataaa gtgttgcaag gaaaatctca
     7501 aaaactcaat atacgttcga ttgctaatag cgaaattaca gagtgggtaa aggcacagac
     7561 caattatcta ttggaaaatt ataatattat aggggatgtg gctctaggta acgaagatac
     7621 ttttaataga attctccaaa aaaaccaaca gttaaattat gatgttaagc aagtaacttt
     7681 gacagaccga tcacgtagca aagcagtatc ttccacaacg acaggatttt tgcttattct
     7741 aatgttaggt agtacgagcg tgatttacag tggtattttg gcagataaat ctagtcagtt
     7801 ataccatcga ttaatgttat cgaacttatc tcgttttcgc tatatgttga gttacgtctg
     7861 tgtaggattt gttgctttta cgattcaaat tgtcattatg ctgagtttgt taaaagtatt
     7921 taatattagt ttttttgttc cgacatcact tcttttgatt atttttttcc tttttagttt
     7981 attagcgata ggctttggcc tgctgattgg agctatcaca caaaattccc aacaaagtag
     8041 ccagttagct aatcttattg taatgccgac ttcaatgttg gctggctgtt tatggccatt
     8101 gtctattacg ccttcttata tgcaagcaat tggtaagtta ttaccacaaa attgggtttt
     8161 atcagccata gctatttttc aaagtggagg gaccttatct caggcttggc catacttgtt
     8221 agctctaatg ggaacagcac tagctttgat tagtttttca agtttattat taaaacctac
     8281 caaactataa
//
