Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000569.1:
Cluster 1RiPP19892

BGC0000569, plantathiazolicin / plantazolicin biosynthetic gene cluster from Bacillus amyloliquefaciens. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: plantazolicin
ChemSpider ID: 28419936
SMILES string: Copy to clipboard
Molecular formula:
Average molecular mass: Da
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
LAP (linear)
Peptides in this cluster:
CBJ61635
RiPP core peptide sequence(s): RCTCTTIISSSSTF
Leader peptide length: 27
Follower peptide length: -1
Peptidase(s) involved in precursor cleavage: cbj61640

Gene cluster description

plantathiazolicin / plantazolicin (BGC0000569). Gene Cluster 1. Biosynthetic class = RiPP. GenBank FN668567, positions 1-9892. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Heterologous expression, Proven expression in natural host, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Doug Mitchell and Rainer Borriss (University of Illinois at Urbana-Champaign, Humboldt University Berlin)

Literature references

1. Scholz R et al. (2011) Plantazolicin, a novel microcin B17/streptolysin S-like natural product from Bacillus amyloliquefaciens FZB42. J Bacteriol 193(1):215-24. doi: 10.1128/JB.00784-10. Epub 2010 Oct 22.
2. Molohon KJ et al. (2011) Structure determination and interception of biosynthetic intermediates for the plantazolicin class of highly discriminating antibiotics. ACS Chem Biol 6(12):1307-13. doi: 10.1021/cb200339d. Epub 2011 Oct
3. Kalyon B et al. (2011) Plantazolicin A and B: structure elucidation of ribosomally synthesized thiazole/oxazole peptides from Bacillus amyloliquefaciens FZB42. Org Lett 13(12):2996-9. doi: 10.1021/ol200809m. Epub 2011 May 13.
4. Deane CD et al. (2013) Engineering unnatural variants of plantazolicin through codon reprogramming. ACS Chem Biol 8(9):1998-2008. doi: 10.1021/cb4003392. Epub 2013 Jul
5. Lee J et al. (2013) Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis. Proc Natl Acad Sci U S A 110(32):12954-9. doi:
6. Liu Z et al. (2013) The highly modified microcin peptide plantazolicin is associated with nematicidal activity of Bacillus amyloliquefaciens FZB42. Appl Microbiol Biotechnol 97(23):10081-90. doi: