{"accession":"BGC0000581","version":6,"changelog":{"releases":[{"version":"1","entries":[{"contributors":["AAAAAAAAAAAAAAAAAAAAAAAA"],"reviewers":["AAAAAAAAAAAAAAAAAAAAAAAA"],"date":"2015-06-12","comment":"Submitted"}],"date":"2015-06-12"},{"version":"2","entries":[{"contributors":["AAAAAAAAAAAAAAAAAAAAAAAA"],"reviewers":["AAAAAAAAAAAAAAAAAAAAAAAA"],"date":"2019-10-16","comment":"Migrated from v1.4"},{"contributors":["AAAAAAAAAAAAAAAAAAAAAAAA"],"reviewers":["AAAAAAAAAAAAAAAAAAAAAAAA"],"date":"2019-10-16","comment":"Updated compound(s) information (NPAtlas curation)"}],"date":"2019-10-16"},{"version":"3","entries":[{"contributors":["AAAAAAAAAAAAAAAAAAAAAAAA"],"reviewers":["AAAAAAAAAAAAAAAAAAAAAAAA"],"date":"2022-09-15","comment":"Updated bioactivity data"}],"date":"2022-09-15"},{"version":"4","entries":[{"contributors":["AAAAAAAAAAAAAAAAAAAAAAAA"],"reviewers":["AAAAAAAAAAAAAAAAAAAAAAAA"],"date":"2022-10-07","comment":"Update chemical activity to schema version 2.11"}],"date":"2022-10-07"},{"version":"next","entries":[{"contributors":["C62OJVVH7XOTOTFZSJT727YU"],"reviewers":["RKFOW2BJ2UIGZ6GYHFZX4BHF"],"date":"2023-10-18","comment":"Added locus coordinates, evidence, completeness, bioactivity, precursor peptide-gene information. Changed PubMed IDs to DOIs, changed subclass to 'Lassopeptide'. Corrected SMILES structure. Added gene product annotation. Added correct strain identifier."}],"date":null},{"version":"6","entries":[{"contributors":["G42B4RI57WLTDHDCD4PMU3MJ","C62OJVVH7XOTOTFZSJT727YU"],"reviewers":["AAAAAAAAAAAAAAAAAAAAAAAA"],"date":"2024-07-23","comment":"MIBiG v4 annotathon"}],"date":"2024-11-15"}]},"quality":"questionable","status":"active","completeness":"complete","loci":[{"accession":"AF061787.1","location":{"from":1,"to":4496},"evidence":[{"method":"Heterologous expression"}]}],"biosynthesis":{"classes":[{"class":"ribosomal","subclass":"RiPP","precursors":[{"gene":"AAD28494.1","core_sequence":"['GGAGHVPEYFVGIGTPISFYG']"}],"ripp_type":"Lasso peptide"}]},"compounds":[{"name":"microcin J25","evidence":[],"bioactivities":[{"name":"antibacterial","observed":true,"references":[]},{"name":"antibacterial (Gram-negative)","observed":true,"references":[]}],"structure":"CCC(C)C(C(=O)NCC(=O)NC(C(C)O)C(=O)N1CCCC1C(=O)NC(C(C)CC)C(=O)NC(CO)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)NCC(=O)O)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C6CCC(=O)NCC(=O)NCC(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)N7CCCC7C(=O)N6)C(C)C)CC8=CN=CN8)C","databaseIds":["pubchem:57397977","npatlas:NPA05946"],"mass":2106.0210761879985,"formula":"C101H139N23O27"}],"taxonomy":{"name":"Escherichia coli AY25","ncbiTaxId":562},"genes":{"annotations":[{"id":"AAD28494.1","name":"mcjA","product":"RiPP precursor peptide"},{"id":"AAD28495.1","name":"McjB","product":"Hydrolase","tailoring":[{"function":"Hydrolysis","references":["doi:10.1002/cbic.201200016","doi:10.1128/JB.181.8.2659-2662.1999","doi:10.1002/cbic.201100596"],"db_reference":"mite:MITE0000056","details":"Hydrolase"}]},{"id":"AAD28496.1","name":"McjC","product":"Macrolactam formation","tailoring":[{"function":"Macrolactam formation","references":["doi:10.1128/jb.181.8.2659-2662.1999","doi:10.1002/cbic.201200016"],"db_reference":"mite:MITE0000055"}]}]},"comment":"BGC was originally isolated from a plasmid: see DOI: 10.1128/jb.181.8.2659-2662.1999","legacy_references":["doi:10.1128/jb.178.12.3661-3663.1996","doi:10.1128/JB.181.8.2659-2662.1999","doi:10.1021/ja036756q","doi:10.1021/ja0367703","doi:10.1039/b708478a","doi:10.1002/cbic.201200016"]}