LOCUS       BGC0000582             12148 bp    DNA     linear   BCT 12-DEC-2010
DEFINITION  Streptomyces sp. OH-4156 putative regulatory protein gene, complete
            cds; and cypemycin gene cluster, complete sequence.
ACCESSION   BGC0000582
VERSION     BGC0000582
KEYWORDS    .
SOURCE      Streptomyces sp. OH-4156
  ORGANISM  Streptomyces sp. OH-4156
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 13:52:41
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12148
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..12148
                     /db_xref="taxon:932694"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp. OH-4156"
                     /strain="OH-4156"
     subregion       1..12148
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="ribosomal"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..12148
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             complement(57..3308)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     168.8; E-value: 3.3e-51)"
                     /gene_kind="regulatory"
                     /note="orf1"
                     /product="putative regulatory protein"
                     /protein_id="ADR72961.1"
                     /transl_table=11
                     /translation="MRDSHRAEAERLWERAVEEELRSSGSRAGAETLLARGRAALDSMA
                     AGAGEEYAAYVRAVEEGETGTRTAANRSSGPVFGGPALVAGVAAVAAVGADLALGTTTG
                     TALGAGAVVAVAGAAATVLRATAGRAGQAVPPTVTAAEPALPDGAVEAARVRWLTALEV
                     RGIRPFLERERVAPADGSGDVPPAEDRTSRDRRAVASRPERLRGADRSAAARQRAVLER
                     SFGHLPDPGGDFAGRREELARITRWVQTGRASAETRPTVVLLHGEPGSGRTALAVRAAH
                     ALRDQFRGACVVDLRGGARDERPLATREALLHLLNRLGAPRERLLFREGATADQQVARL
                     TELYQRQLTGVPVTVILDDAVDAAQVRALLPERSESLVLVTCREPLDLGDVAAHVLPVA
                     ALDAAGAEELLLAAGGQRDPGPYDAEALDRIRELCGGLPLALRAAGSLLGRRSMDDLAE
                     VLGRPGWGDAPVERALWARYFVDLDDEARRLLRRLSLAGRASLGAAAAAALLDGSGADG
                     ARLLRELAGAGLLAPVRGERYRLHDAVRGFAALRLLDEEDAAEIAAAQERLIRNYAELA
                     DAVIRMVDGKMSTRANRFDGHGFGSLEAALSWLDEESSFITAALRHTDGVDQQTVLDLL
                     GALCDYCLLRGDLYRLGEINELAEAVGQGQLSRSVQWRTGIAARQLGELDKARTTLTSV
                     VSLYQEAHQDPGAALALCSLGITLHHQGRLTDAAARLREALALQEPEALAADRGWTLHA
                     LAAVERDRGNLAEATALLDRSLALHRQHESPHGQAWAHFQRGQVLLLRGDVPGAEAGLR
                     EALDGYGRIHDGRGEAWALTQLARARLAAGDAEPAVEGLRGALARHREQEDARGEAWTL
                     FHLAHALEERGDRDDAVRELGRARTMFSRMRDVYGLASARHHSGRVTRDQLAARTGGLR
                     NSGFARQLLVDARADFHRIGVPHGEAWTSLELAIIDAGNARVPQALGLCDEARALFGTY
                     GDLRGADWARFLRCTLLPHAVPGSPEPGTVTAREELAALVADRHPARDPRLDDCAEAYA
                     VVLGRGIHPSTPWQAWDLGMVPNRHAREVLGVPAG"
     regulatory      complement(3318..3322)
                     /note="putative"
                     /regulatory_class="ribosome_binding_site"
     regulatory      3868..3872
                     /note="putative"
                     /regulatory_class="ribosome_binding_site"
     misc_feature    3868..12074
                     /note="cypemycin gene cluster"
     CDS             3882..4076
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     linaridin: cypemycin"
                     /gene_kind="biosynthetic"
                     /note="cypA"
                     /product="cypemycin structural protein"
                     /protein_id="ADR72962.1"
                     /sec_met_domain="cypemycin (E-value: 4e-34, bitscore:
                     106.2, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSEMTLTSTNSAEALAAQDFANTVLSAAAPGFHADCETPAMATP
                     ATPTVAQFVIQGSTICLVC"
     regulatory      4094..4130
                     /note="putative transcriptional attenuator"
                     /regulatory_class="attenuator"
     regulatory      4175..4179
                     /note="putative"
                     /regulatory_class="ribosome_binding_site"
     CDS             4191..5945
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /note="cypH; contains N-terminal HTTM domain and C-terminal
                     alpha/beta hydrolase fold"
                     /product="hypothetical protein"
                     /protein_id="ADR72963.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.1e-11, bitscore:
                     33.6, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRWKWRRQYASNAKGAQEAADRVFLPIAIGQALAAAETLFIREEF
                     EDDGYLRGTSAQQYPQGTLRHRIGRVLDHPRTPRVLAGVTLAASAGLALARGNRKAQIA
                     AAAVIGTCNRLSEIRTPYGRDGADQMTAVITQYRALTGLIPDQRLSDDLFLRAVNLQAG
                     LSYAVSGISKAFGSSWVQGDALLEVLQTEAYGRGPAAAILRKYPRLCRALTVGTVVWET
                     SFPLIYLLPREQASYALHAVKAFHVGVATAMELPRFVWGFFGSHGAVGYVLDTRGAPRT
                     FEKAVFGIAGGAVLTSALIAREKRRIAEQRRLGPKGAARLRHGDGDVEYRVDRPAEGTP
                     SRGVIVLECGLGQSFESWEWVAESLAEHHTVIRYHRSGYGLTTSRAANGDLLAAVLDEV
                     GAEGRIVVATHSIGSLSAASYLGEGPFAGRVDKLIVVDGTDPVLLDEDRTDRRRLGRFL
                     QAQVYTLVAALTGIYEWAPNAVERQAGYTPDVQYSHVQFVFSPRNIVNSVREYRRIRTE
                     GAVDRLGAVDSVLVVASDEYAEQQAVLAEKLGAKFEVVRGSAHRSIIGYRAHAEQVEGA
                     IRRFMDAY"
     regulatory      5923..5927
                     /note="putative"
                     /regulatory_class="ribosome_binding_site"
     CDS             5935..6495
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     linaridin: cypI"
                     /gene_kind="biosynthetic"
                     /note="cypL"
                     /product="unknown"
                     /protein_id="ADR72964.1"
                     /sec_met_domain="cypI (E-value: 1.7e-32, bitscore: 101.9,
                     seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTDRIKGGAATVAVGALAAHLVATVLQNTPDSYNQDMRTFTGGW
                     PIPGWRFFAPNPGVQNVHLLVRETTDEGPTPWRDVTPVVPHGWTQVLYNPRSRGPKALF
                     DAMQQLSIMSANQADFSWVTQSLPYDLVLAASRAAVADNARALQFLLMNVFPSAPADQR
                     MKPILTSEWIPLGTGRRPAGAAA"
     regulatory      6481..6485
                     /note="putative"
                     /regulatory_class="ribosome_binding_site"
     CDS             6492..7064
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /note="cypD"
                     /product="HFCD family decarboxylase"
                     /protein_id="ADR72965.1"
                     /sec_met_domain="Flavoprotein (E-value: 9.9e-14, bitscore:
                     40.7, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVEKFEGAELHVHVTGSISAALVPWWIHWLREFQPELVVNVSVT
                     PAASRFLAVRALRHLANGKVWVDSWDDPDVPPEVNSGKSGASECFLVFPATLDTVMRLA
                     QGRADSPALMMLQLTDAPLVIADTFPGSNEIVENNVQTLKLRPNVEFAPRVNGVRASNR
                     QTAEVGFNLPGALAAANRMRKEGRSGE"
     regulatory      7044..7048
                     /note="putative"
                     /regulatory_class="ribosome_binding_site"
     CDS             7057..7794
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248:methyltransferase (Score: 83.8; E-value:
                     2.2e-25)"
                     /gene_kind="biosynthetic-additional"
                     /note="cypM"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="ADR72966.1"
                     /transl_table=11
                     /translation="MSDPSVYDETAIEAYDLVSSMLSPGAGLVAWVSSHRPLDGRTVLD
                     LGCGTGVSSFALAEAGARVVAVDASRPSLDMLEKKRLDRDVEAVEGDFRDLTFDSTFDV
                     VTMSRNTFFLAQEQEEKIALLRGIARHLKPGGAAFLDCTDPAEFQRAGGDARSVTYPLG
                     RDRMVTVTQTADRAGQQILSIFLVQGATTLTAFHEQATWATLAEIRLMARIAGLEVTGV
                     DGSYAGEPYTARSREMLVVLERQ"
     regulatory      7782..7786
                     /note="putative"
                     /regulatory_class="ribosome_binding_site"
     CDS             7791..8423
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 121.7; E-value:
                     6.5e-37)"
                     /gene_kind="transport"
                     /note="cypT"
                     /product="ABC transporter ATP binding subunit"
                     /protein_id="ADR72967.1"
                     /transl_table=11
                     /translation="MSEVPAIAAEGATVVLDGTTLLAPTTFEVMPGEFWCLTGSNGSGK
                     TTLLRAFLGSRRLTDGAVLVRGETVDMARPRHRRLMASLVEPVPVARDMTLREQVTLVA
                     ASWYGNSTETAARADEIIGRLGLTALGTRFPSQLSSGQLQLFNLALTLVRPADVILLDE
                     PERHLDTDRVGLVAALLAERAEQGTSFLVATHEAAMVDACDGLMELG"
     regulatory      8411..8415
                     /note="putative"
                     /regulatory_class="ribosome_binding_site"
     CDS             8420..9970
                     /codon_start=1
                     /note="cypP; contains 12 transmembrane helices"
                     /product="putative transmembrane pore"
                     /protein_id="ADR72968.1"
                     /transl_table=11
                     /translation="MTTDSITAVEADPRDRVHAVRHRYAHRGDRATVQDWAYTVYLSVI
                     LGAVYVAPVVYLVRTTEALVSLPSAGAATPVACLVAAAVFWGAQLTGRFWGPLVLKPFL
                     LHVFMSTDLSPTHYLGTIARRRLGYAGLGTLLAVCTATFLATDLFDRPGSALLPQSLAV
                     AVGVGAVAPVAWLWGQVRTVRENVLLAAAVAVVAAATALLGRSALLGGSGPWLVTGVLA
                     AAAALLGRSAFRSVRTVDLARLARESARAAEAQTFAWTGTLHHALDLYRPQPRGLTSAL
                     TRPDGRLRGHLAQGAVRAVRTRGRALAAAVFLPAGGALLTLGVAEPDARLATLSWMTGA
                     VGVYLGSGWTGESWRGLRDELTLAPLLGEWWGGLLARTLAWPVVAVVVPVGLASAVTVL
                     ARWPLQGGGPSDAVLLTAGSVVLVLGARFLREMKMNLPVELLLPLITPLGDLSAVRVFV
                     WQFDGLVVVLAGVLVMNGMPSASGAALIALGAAACCVWAGLRRTGWSLRPLVARLGRV"
     regulatory      10039..10043
                     /note="putative"
                     /regulatory_class="ribosome_binding_site"
     CDS             10053..12074
                     /codon_start=1
                     /note="cypI"
                     /product="DUF255 family protein"
                     /protein_id="ADR72969.1"
                     /transl_table=11
                     /translation="MANRLAHETSPYLLQHADNPVDWWPWSAEAFDEARRRDVPVLLSV
                     GYSSCHWCHVMAHESFEDDATAALVNENFVAVKVDREERPDVDAVYMEAVQAATGQGGW
                     PMTVFLTPDAAPFYFGTYFPPEPRHGMPSFPEVLEGVKGAWSDRRDEVGEVAERIVKDL
                     AGRSLAYGGDGVPGEEELAQALLGLTREYDATHGGFGGAPKFPPSMTLEFLLRHHARTG
                     SEGALQMAADTCEAMARGGIYDQLGGGFARYAVDRAWVVPHFEKMLYDNALLCRAYAHL
                     WKATGSDLARRVALETADFLVRELRTPEGGFASALDADSDDGTGRHVEGAYYVWTPAQL
                     TEVLGAEDAALAAAHYGVTEDGTFEHGSSVLQLPREAGTADAGRIASIAARLLAAREER
                     ERPGRDDKVVAAWNGLAIAALAETGALFDRPDLVERATEAADLLVRVHMDESARLTRTS
                     KDGRAGTNDGVLEDYADVAEGFLALAAVTGEGAWLDFAGFLLDLVIDRFTAEGGALYDT
                     AHDAEALIRRPQDPTDNATPSGWTAAAGALLSYAAHTGSDAHRAAAEGALGVVKALGPR
                     APRFIGWGLAVSEALLDGPREIAVVGAPGDEAFQELRRTALLATAPGAVLAFGAPDSEE
                     FPLLRDRPLVSGGPAAYVCRHFTCDAPVTDPDALRRKL"
ORIGIN
        1 gtgccgccgg gcccgtactt caccgcgtcc gggggtgccg tcatggaacg gcccggctac
       61 cccgccggca cccccaggac ctcccgggcg tgccggttcg gcaccatgcc caggtcccag
      121 gcctgccagg gcgtcgacgg gtggatgccc cggcccagga ccaccgcgta cgcctccgcg
      181 cagtcgtcga gccgcgggtc gcgcgccgga tgccggtccg cgaccagcgc cgcgagctcc
      241 tcgcgcgccg tgaccgtccc cggctccggg ctccccggga ccgcgtgcgg gagcagcgtg
      301 cagcgcagga accgggccca gtccgcgccc cgcagatcgc cgtacgtgcc gaacagcgca
      361 cgggcctcgt cgcacagccc cagcgcctgc ggcacccggg cgttgccggc gtcgatgatc
      421 gccagctcca gcgaggtcca ggcctccccg tgcggcaccc cgatccggtg gaagtccgcc
      481 cgagcgtcca cgagcagctg ccgggcgaag cccgaattgc gcagaccgcc ggtgcgggcc
      541 gcgagctggt cgcgggtgac ccgccccgaa tgatgccggg cgctggccag cccgtacacg
      601 tcccgcatcc gcgagaacat cgtccgcgcc ctgcccagct cccgtaccgc gtcgtcccgg
      661 tccccgcgct cctccagcgc gtgggccaga tggaacagcg tccacgcctc cccgcgcgcg
      721 tcctcctgct cccggtgccg ggcgagcgcc ccgcgcagcc cctcgacggc cggttcggcg
      781 tccccggcgg cgagccgcgc cctggccagc tgggtcagcg cccaggcctc gccgcgaccg
      841 tcgtggatcc gcccgtagcc gtcgagggcc tcccgcagcc cggcctccgc gcccggcacg
      901 tccccccgca gcagcagcac ctggccccgc tggaagtggg cccaggcctg gccgtgcggg
      961 gactcgtgct gccggtgcag cgcgagcgac cggtcgagca gtgccgtcgc ctccgccagg
     1021 ttcccccggt cccgctccac ggccgcgagc gcgtgcagcg tccagccccg gtcggcggcg
     1081 agcgcctccg gttcctggag cgcgagcgcc tcccgcagcc gggccgccgc gtccgtgagc
     1141 cggccctggt ggtgcagggt gatgccgagc gagcagagcg cgagcgccgc ccccgggtcc
     1201 tggtgggcct cctggtagag cgacaccacg gacgtcaggg tcgtccgcgc cttgtcgagc
     1261 tcgccgagct gccgggccgc gatgccggtc cgccactgca cggagcggga cagctggccc
     1321 tgcccgacgg cctcggccag ttcgttgatc tcgccgagcc ggtagaggtc gccgcgcagc
     1381 aggcagtagt cgcagagcgc gcccagcaga tcgagcacgg tctgctggtc gacgccgtcc
     1441 gtgtgccgca gggccgccgt gatgaagctg gactcctcgt cgagccagct cagggccgcc
     1501 tccagggacc cgaagccgtg cccgtcgaaa cggttggcgc gggtcgacat cttgccgtcg
     1561 accatccgga tcaccgcgtc cgcgagctcc gcgtagttcc gtatcaaccg ctcctgggcc
     1621 gccgcgatct ccgccgcgtc ctcctcgtcg aggagccgga gcgccgcgaa gccgcgtacc
     1681 gcgtcgtgca gccggtaccg ctccccgcgc accggggcga gcagccccgc gccggccagc
     1741 tcgcgcagca gccgggcgcc gtcggcgccg ctcccgtcga gcagcgcggc ggcggccgcg
     1801 gcgccgaggg aggcacgtcc ggcgagcgaa agacgccgca gcagccgccg ggcctcgtcg
     1861 tcgagatcga cgaagtaccg tgcccacaga gcgcgttcga ccggggcgtc gccccagccc
     1921 ggtcggccga gcacctccgc gagatcgtcc atggaccgcc ggcccagcag ggaccccgcc
     1981 gcccgcagcg ccagcggaag accgccgcac agctcccgga tccggtcgag cgcctccgcg
     2041 tcgtacggac cgggatcccg ctgcccgccc gccgccagca acagctcctc cgccccggcc
     2101 gcgtcgagcg ccgccaccgg caggacgtgc gcggccacgt cccccaggtc cagcggctcc
     2161 cggcaggtca ccaggaccag gctctcggaa cgctccggca gcagcgcccg cacctgggcc
     2221 gcgtccacgg cgtcgtccag gatcaccgtc accggcaccc cggtcagctg ccgctggtac
     2281 aactccgtca gccgcgccac ctgttggtcc gccgtggcgc cctcccggaa gaggagccgc
     2341 tcgcgcgggg cgcccagccg gttgagcaga tggagcagcg cctcccgggt cgcgaggggc
     2401 cgctcatcgc gtgctcctcc ccgcaggtcc accacgcacg ccccgcggaa ctggtcgcgg
     2461 agcgcgtgcg ccgcccgtac cgcgagagcc gtccgcccgg acccgggctc gccgtgcagc
     2521 aggaccaccg tcggccgggt ctccgccgag gcgcgccccg tctgcaccca ccgggtgatc
     2581 cgggccagct cctcccgtcg gcccgcgaag tccccgccgg ggtcgggcag atgcccgaag
     2641 gaccgctcca gtacggcccg ctgccgggcc gccgcgctgc gatcggcccc gcgcagccgc
     2701 tcgggccgcg acgccaccgc ccgccggtcc cgggaggtcc ggtcctccgc cggaggtacg
     2761 tccccgctcc cgtcggccgg cgccacccgc tcccgctcca ggaacgggcg tatgccccgt
     2821 acctccaggg ccgtcagcca gcgcacccgc gccgcctcga cggcgccgtc cggcagcgcc
     2881 ggctccgctg ccgtcaccgt cggcggcacg gcctgcccgg cccgtcccgc cgtcgccctc
     2941 agcaccgtcg ccgccgcgcc cgccaccgcc accaccgcgc ccgcgccgag cgccgtcccc
     3001 gtcgtcgtgc cgagcgccag gtccgcgccg accgcggcga cggccgcgac tccggcgacg
     3061 agcgcgggac cgccgaacac cgggccggag gagcggttcg ccgcggtccg ggtgccggtc
     3121 tccccctcct ccacggcccg tacgtacgcc gcgtactcct cgcccgcacc cgccgccatc
     3181 gagtccagcg cggcccggcc ccgggcgagc agggtctccg cgcccgcccg gctcccggag
     3241 ctccgcagct cctcctccac cgcccgttcc cacagccgct cagcctcggc ccgatggctg
     3301 tcccgcatgt gcgtccccct ccgcgcgtgc ccgcccatcc cgtccctgag gccctgtcag
     3361 accccggacc gtgcgcgtcc agtgtgctgc gcggggcgcg aaggcgcgag agcgggcaaa
     3421 ggagggccgg ccgcggcggg acggtcggca tcccgaacgg tgaggggtgt ggtggggcga
     3481 gaactggccg gatgccgagc gggccgggct ccgtggggcc cggcacccga ggcttccgcg
     3541 cccggccccc gggcggcggg gcgcccccgc gaggcggccc ctcaaacacc gttcgcggcc
     3601 ggcgaaatca ccgccctcaa tcttccgagt cgccccgtat aaaggatccg tagtgatggc
     3661 cgaaaagagc tgtcacttca gttgctttcc tggtcctgtg ttatgcggca agaggccgtc
     3721 aattgcgctt gacggtctct tgaaggtctg cctaaggtcg gtccgcaacg tctagttgca
     3781 aacgttgtgc agcgcgttca cacagagcgg gcgacgaggg tggcaacgtt cgatacgcct
     3841 ggaccattcg ctcgcatgac caccgacgaa gggttagtga agtgcgatct gagatgactc
     3901 ttacgagcac gaattccgct gaggctctgg cggcgcagga ctttgcgaac accgttctca
     3961 gcgcggcggc cccgggcttc cacgcggact gcgagacgcc ggccatggcc accccggcca
     4021 cgccgaccgt cgcccagttc gtgatccagg gcagcacgat ctgcctggtc tgctgacgcg
     4081 ggactgagcc tgccgccgga gaggcccgtc accaccgggc ctctccggcg cgcggttccg
     4141 cacgactcag gacggcggcc aggtatgcga cgggggagac ggacaatccg gtgagatgga
     4201 agtggcggag gcagtacgcc tcgaatgcga aaggcgctca ggaagcggcc gaccgcgtat
     4261 ttcttccgat agcgatcggg caggccctgg cggccgcgga gacccttttt atccgtgaag
     4321 aattcgaaga cgacggatat ctcagaggca cgtcggccca gcagtatccg caaggcacat
     4381 tacgacaccg gataggccgc gtactcgacc atccgcgcac tccccgcgtg ctcgcgggag
     4441 tgaccctcgc cgcatcggcc gggctggcgc tcgcacgcgg caaccggaag gcgcagatcg
     4501 ccgccgcggc ggtcatcggg acgtgcaacc ggctgagcga gatccgcacc ccgtacggac
     4561 gggacggcgc ggaccagatg acggcggtca tcacgcagta ccgggccctc acggggctga
     4621 ttcccgacca gcggctctcc gacgacctct tcctgcgcgc ggtcaacctc caggccggac
     4681 tgagctacgc ggtctcggga atctccaagg ccttcggcag cagctgggtc cagggcgacg
     4741 ccctgctcga agtcctgcag acggaggcgt acggccgggg gcccgccgcg gcgatcctgc
     4801 gcaagtaccc gcgactctgc cgggccctga ccgtcggaac ggtggtgtgg gagacgtcct
     4861 tcccgctcat ctacctgctg ccgcgcgagc aggcctcgta cgcgctccac gccgtcaagg
     4921 ccttccacgt cggcgtggcg acggccatgg aactgccgcg cttcgtctgg gggttcttcg
     4981 gctcccacgg agccgtcggc tacgtcctgg acacccgagg cgcaccccgg accttcgaga
     5041 aggccgtgtt cggcatcgcc ggcggcgccg tcctcacgag cgcgctgatc gcgcgcgaga
     5101 agcgccggat cgccgagcag cggcggctcg gccccaaggg cgccgcgcgg ctccgccacg
     5161 gcgacggcga cgtcgagtac cgggtggacc gtcccgcgga ggggaccccc tcccgcggcg
     5221 tgatcgtcct ggagtgcggc ctcggacagt ccttcgaatc gtgggagtgg gtcgcggaga
     5281 gcctggccga gcaccacacg gtcatccgct accaccgctc cggatacggc ctcacgacgt
     5341 cccgcgcggc caacggcgac ctgctcgccg ccgtgctcga cgaggtcggg gccgaggggc
     5401 ggatcgtggt ggccacccac tcgatcggat cgctgagcgc ggcctcctac ctgggcgagg
     5461 gtcccttcgc cggccgcgtc gacaagctga tcgtcgtcga cggcaccgac ccggtgctgc
     5521 tggacgagga ccgcacggac cgcaggcggc tcggccggtt cctccaggcg caggtctaca
     5581 cgctcgtcgc ggcgctcacc ggaatctacg agtgggctcc caacgcggtg gagcggcagg
     5641 cgggctacac gcccgacgtc cagtacagcc acgtgcagtt cgtgttctcg cccaggaaca
     5701 tcgtcaactc ggtccgcgag taccggcgca tccgcaccga gggcgccgtg gaccgtctcg
     5761 gcgcggtcga ctcggtcctg gtcgtcgcct ccgacgagta cgccgagcag caggcggtgc
     5821 tggccgagaa gctcggggcg aagttcgagg tggtgcgcgg ctcggcgcac cggtcgatca
     5881 tcggataccg ggcgcacgcc gaacaggtcg agggcgctat cagaaggttc atggatgctt
     5941 actgaccgga tcaagggcgg ggcggccacc gtcgcggtcg gggcgctcgc cgcgcacctg
     6001 gtcgcgaccg tgctgcagaa cacccccgac tcgtacaacc aggacatgcg cacgttcacg
     6061 ggcggctggc ccattcccgg ctggcggttc ttcgcaccga acccgggtgt gcagaacgtg
     6121 cacctgctgg tgcgggagac caccgacgag ggcccgacgc cgtggcgcga cgtgaccccc
     6181 gtcgtaccgc acgggtggac gcaggtgctg tacaacccgc ggagccgcgg gcccaaggcg
     6241 ctcttcgacg ccatgcagca gctctccatc atgagcgcga accaggccga cttctcgtgg
     6301 gtcacccaga gcctgccgta cgacctggtg ctcgcggcga gccgggccgc ggtggccgac
     6361 aacgcccggg cgctgcagtt cctgctgatg aacgtgtttc ccagcgcgcc cgcggaccag
     6421 cggatgaagc cgatcctcac ctccgagtgg atccccctcg gcaccgggcg ccgcccggcg
     6481 ggagccgccg cgtgaacgtg gagaagttcg agggcgcgga gctgcacgtc catgtcacgg
     6541 gctccatcag cgcggcgctc gtgccgtggt ggatccactg gctgcgggag ttccagccgg
     6601 aactggtcgt gaacgtgtcg gtgacgcccg ccgcgtcgcg gttcctggcg gtccgggcgc
     6661 tccggcacct ggccaacggg aaggtgtggg tcgactcctg ggacgacccg gacgtgccgc
     6721 ccgaggtcaa ctcggggaag agcggcgcct ccgagtgctt cctggtcttc cccgccacgc
     6781 tggacaccgt gatgcgcctg gcgcaggggc gcgcggactc gcccgccctc atgatgctcc
     6841 agctgaccga cgcgcccctc gtgatcgcgg acacgttccc ggggtccaac gagatcgtcg
     6901 agaacaacgt gcagaccctc aagctccgcc cgaacgtcga gttcgcgccg cgggtcaacg
     6961 gcgtacgcgc gagcaaccgg cagacggccg aggtggggtt caacctgccg ggtgccctcg
     7021 ccgcggccaa caggatgcgg aaggaagggc gttccggtga gtgacccgag cgtgtacgac
     7081 gagacggcga tcgaggcgta cgacctggtg tcgtcgatgc tctccccggg ggccgggctc
     7141 gtcgcctggg tgtcgtcgca ccgtcccctg gacgggcgga ccgtcctcga cctggggtgc
     7201 ggcacgggcg tgtcctcgtt cgcgctcgcc gaggccggcg cgcgggtcgt ggcggtcgac
     7261 gcctcacggc cgtccctgga catgctggag aagaagcgcc tcgaccgcga cgtcgaggcg
     7321 gtggagggcg atttccgcga cctcacgttc gactcgacgt tcgacgtcgt cacgatgtcc
     7381 cggaacacct tcttcctcgc ccaggagcag gaggagaaga tcgcgctcct gcgcggcatc
     7441 gcccggcacc tgaagccggg cggcgcggcc ttcctggact gcaccgaccc cgccgagttc
     7501 cagcgcgcgg gcggcgacgc gcggtcggtc acctacccgc tgggccggga ccggatggtg
     7561 acggtgaccc agaccgcgga ccgcgccggc cagcagatcc tgagcatctt cctggtccag
     7621 ggcgcgacga ccctcaccgc gttccacgag caggccacct gggctacgct ggcggagatc
     7681 cggctgatgg cgcggatcgc gggtctggag gtgacgggcg tcgacgggtc gtacgcggga
     7741 gagccctaca ccgcgcgctc gcgggagatg ctggtcgttc tggagcggca gtgagcgaag
     7801 tgccggcgat cgccgcggag ggcgccacgg tcgtcctgga cgggaccacc ctcctcgcgc
     7861 cgacgacgtt cgaggtgatg cccggcgagt tctggtgcct caccggaagc aacggctccg
     7921 ggaagacgac cctgctgcgg gccttcctgg ggagccggag gctgacggac ggcgccgtcc
     7981 tcgtccgcgg cgagaccgtc gacatggcca ggccccggca ccggcgcctg atggcctcgc
     8041 tcgtcgaacc ggtccccgtc gcccgtgaca tgacgctccg cgagcaggtg accctggtcg
     8101 ccgcctcctg gtacggcaac agcacggaga ccgccgcacg cgccgacgag atcatcgggc
     8161 gactggggct caccgccctg ggcacccgct tcccctccca gctctcctcc ggccagctcc
     8221 agctcttcaa cctcgcgctg accctggtcc gccccgccga cgtcatcctc ctcgacgaac
     8281 cggagcggca tctcgacacc gatcgcgtcg gcctcgtcgc cgccctgctc gccgagcgcg
     8341 cggagcaggg cacgtcgttc ctggtcgcca cccatgaggc cgcgatggtg gacgcctgcg
     8401 acggcctcat ggagctggga tgaccacgga cagcatcacc gcggtcgagg ccgaccccag
     8461 ggaccgcgtc cacgccgtac ggcaccggta cgcccaccgc ggcgaccgcg ccacggtgca
     8521 ggactgggcg tacaccgtct acctcagcgt catcctcggc gccgtctacg tggcgcccgt
     8581 cgtctacctg gtgagaacca cggaggcgct cgtctccctg ccgtccgccg gagcggcgac
     8641 gcccgtggcg tgcctggtcg cggcggcggt gttctgggga gcccagctca ccggccggtt
     8701 ctggggcccg ctggtgctca agccgttcct gctgcacgtg ttcatgtcga cggacctgtc
     8761 cccgacgcac tacctcggca cgatcgcccg ccgccggctc gggtacgcgg gactcggcac
     8821 gctcctggcg gtctgcacgg cgacgttcct cgcgaccgac ctgttcgacc ggccgggaag
     8881 cgcgctgctg ccacagagcc tggccgtcgc ggtgggcgtc ggcgccgtcg cccccgtggc
     8941 ctggctgtgg ggccaggtcc ggacggtgcg cgagaacgtc ctgctcgccg ccgccgtggc
     9001 cgtcgtggcg gccgccaccg ccctgctcgg ccggtccgcc ctcctgggcg gcagcggccc
     9061 gtggctcgtc accggtgtcc tcgcggccgc ggccgccctg ctcggccggt ccgccttccg
     9121 gtccgtccgt acggtcgacc tcgcccggct cgcccgtgag tcggcgcgtg ccgccgaggc
     9181 ccagaccttc gcctggaccg gcacgctcca ccacgcgctc gacctgtacc gaccgcagcc
     9241 gcgcgggctc acgtccgccc tcacgcgccc cgacgggcgg ctgcgcggcc acctcgccca
     9301 aggggcggtc cgcgcggtcc gcacccgggg ccgcgcgctc gcggccgcgg tgttcctgcc
     9361 ggccggcggc gccctgctga cgctcggcgt cgccgagccg gacgcccggc tcgcgaccct
     9421 gtcctggatg accggcgcgg tcggcgtgta cctggggtcc gggtggaccg gcgagagctg
     9481 gcgcggactg cgcgacgagc tgaccctggc cccgcttctc ggcgagtggt ggggtggcct
     9541 gctcgcccgc accctggcct ggccggtcgt cgccgtggtg gtcccggtgg ggctcgcgag
     9601 cgccgtcacc gtcctggccc ggtggccgct ccagggcggc ggaccgtccg acgcggtgct
     9661 gctcacggcg gggtcggtgg tgctcgtgct gggcgccagg ttcctgcgcg agatgaagat
     9721 gaacctgccc gtagaactgc tgcttcccct catcacgccg ctgggcgacc tctccgccgt
     9781 ccgcgtcttc gtctggcagt tcgacggact cgtcgtcgtc ctggccggcg tcctcgtgat
     9841 gaacgggatg ccgtccgcgt ccggcgcggc cctgatcgcc ctgggtgcgg ccgcctgctg
     9901 cgtctgggcg ggcctgcgcc gcacaggctg gtccctccgg cccctcgtcg cccgcctcgg
     9961 cagggtgtaa cggagccccg cgggagtggc ccccggtccg cctggggcag gggtcccgcg
    10021 cgactccggg acggcagggc aggatggaca ccatggcgaa ccgactggcc catgagacct
    10081 ccccgtacct ccttcaacac gccgacaacc cggtcgactg gtggccgtgg tcggccgagg
    10141 ccttcgacga ggcccggcgc cgcgacgtcc ccgtgctgct cagcgtcgga tacagctcct
    10201 gccactggtg ccacgtcatg gcgcacgagt ccttcgagga cgatgccacc gcggccctgg
    10261 tcaacgagaa cttcgtcgcc gtcaaggtcg atcgcgagga gcgccccgac gtcgacgccg
    10321 tctacatgga ggccgtccag gccgcgaccg gccagggcgg ctggcccatg accgtcttcc
    10381 tcaccccgga cgcggccccc ttctacttcg gtacgtactt cccgcccgag ccccgccacg
    10441 gcatgccctc cttcccggag gtcctggagg gcgtcaaggg cgcctggtcc gaccggcgcg
    10501 acgaggtcgg cgaggtcgcg gagcgcatcg tgaaggacct cgcgggccgc tccctggcgt
    10561 acggcggcga cggcgtcccc ggcgaggagg aactcgccca ggccctcctc ggactcaccc
    10621 gcgagtacga cgcgacccac ggcggcttcg gcggcgcccc caagttcccg ccgtccatga
    10681 ccctggagtt cctgctccgc caccacgccc gtacgggctc cgagggcgcc cttcagatgg
    10741 ccgccgacac ctgcgaggcg atggcccgcg gcggcatcta cgaccagctc ggcggcggct
    10801 tcgcccgcta cgccgtcgac cgcgcctggg tcgtgcccca cttcgagaag atgctgtacg
    10861 acaacgccct gctctgccgg gcctacgccc acctgtggaa ggccaccggc agcgacctgg
    10921 cccgccgggt cgccctggag accgccgact tcctggtccg cgaactgcgc acccccgagg
    10981 gcggtttcgc ctcggcgctc gacgcggaca gcgacgacgg aacgggcagg cacgtcgagg
    11041 gcgcctacta cgtgtggacc ccggcgcagc tcaccgaggt cctcggcgcg gaggacgccg
    11101 ccctcgccgc cgcccactac ggcgtcaccg aggacggcac cttcgagcac ggcagctccg
    11161 tcctccagct tccgcgggag gccggaaccg ccgacgccgg ccggatcgcc tcgatcgccg
    11221 cccggctcct cgccgcccgc gaggagcgcg agcgtccggg ccgcgacgac aaggtcgtcg
    11281 ccgcctggaa cggtctcgcg atcgccgccc tcgccgagac cggcgccctc ttcgaccgcc
    11341 ccgacctcgt cgagcgcgcc accgaggccg ccgacctcct cgtccgggtc cacatggacg
    11401 agtccgcccg cctcacccgt acgtccaagg acggccgggc cggcaccaac gacggtgtcc
    11461 tggaggacta cgccgacgtc gccgagggct tcctcgccct cgccgccgtc accggcgagg
    11521 gcgcctggct cgacttcgcc ggcttcctcc tggacctcgt catcgaccgc ttcaccgccg
    11581 agggcggcgc cctctacgac acggcccacg acgccgaggc gctgatccgc cgcccgcagg
    11641 accccacgga caacgccacc ccgtcgggct ggacggccgc ggccggcgcg ctgctctcgt
    11701 acgccgcgca caccggctcg gacgcccacc gcgccgccgc cgagggcgcc ctcggcgtcg
    11761 tcaaggccct cggcccgcgc gcgccccgct tcatcggctg gggcctggcc gtctccgagg
    11821 ccctcctcga cgggccccgg gagatcgccg tggtgggcgc ccccggcgac gaggccttcc
    11881 aggagctgcg ccgtaccgcg ctcctggcga ccgcccccgg cgcggtgctc gccttcggcg
    11941 cccccgacag cgaggagttc ccgctgctga gggaccgtcc gctggtgtcc ggtggtcccg
    12001 ccgcgtacgt gtgccgtcac ttcacctgtg acgcgccggt gaccgacccg gacgcactgc
    12061 gccggaagct ctgaggcctc cggaacgggg acggccccgc gacccctccg aggaggggcg
    12121 gcggggccgc gccgtgccgg gcgtcgtc
//
