Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000582.1:
Cluster 1RiPP112148

BGC0000582, cypemycin biosynthetic gene cluster from Streptomyces sp. OH-4156. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: cypemycin
SMILES string: Copy to clipboard
Molecular formula: C99H154N24O24S
Exact molecular mass: 2095.1289 Da (M+H+)
Molecular activity: Antibacterial, Cytotoxic

Class-specific details

Biosynthetic class(es):
RiPP subclass:
Linaridin (cyclic)
Peptides in this cluster:
RiPP core peptide sequence(s): ATPATPTVAQFVIQGSTICLVC
Leader peptide length: 42
Follower peptide length: -1
Peptidase(s) involved in precursor cleavage:
Crosslinks in final product:
19=22 AA (Thioether)

Gene cluster description

cypemycin (BGC0000582). Gene Cluster 1. Biosynthetic class = RiPP. GenBank HQ148718. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Heterologous expression, Proven expression in natural host
Comments:Paper reporting the cypemycin structure is not archived in PubMed: Minami Y, et al. (1994) Structure of cypemycin, a new peptide antibiotic. Tetrahedron Lett 35:8001-8004
Contact for this cluster:Jan Claesen (University of California at San Francisco)

Literature references

1. Claesen J, Bibb M. (2010) Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides. Proc Natl Acad Sci U S A 107(37):16297-302. doi:
2. Zhang Q, van der Donk WA. (2012) Catalytic promiscuity of a bacterial alpha-N-methyltransferase. FEBS Lett 586(19):3391-7. doi: 10.1016/j.febslet.2012.07.050. Epub
3. Komiyama K et al. (1993) A new antibiotic, cypemycin. Taxonomy, fermentation, isolation and biological characteristics. J Antibiot (Tokyo) 46(11):1666-71.