Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000583.1:
Cluster 1RiPP16725

BGC0000583, grisemycin biosynthetic gene cluster from Streptomyces griseus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: grisemycin
SMILES string: Copy to clipboard
Molecular formula: C86H137N21O21S
Exact molecular mass: 1832.0019 Da (Molecular ion)
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
RiPP subclass:
Linaridin (cyclic)
Peptides in this cluster:
RiPP core peptide sequence(s): atpavaqfviqgsticlvc
Leader peptide length: 45
Follower peptide length: -1
Peptidase(s) involved in precursor cleavage:
Crosslinks in final product:
16=19 AA (Thioether)

Gene cluster description

grisemycin (BGC0000583). Gene Cluster 1. Biosynthetic class = RiPP. GenBank NC_010572, positions 7570210-7576934. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression, Proven expression in natural host
Contact for this cluster:Jan Claesen (University of California at San Francisco)

Literature references

1. Claesen J, Bibb MJ. (2011) Biosynthesis and regulation of grisemycin, a new member of the linaridin family of ribosomally synthesized peptides produced by Streptomyces griseus IFO 13350. J Bacteriol 193(10):2510-6. doi: 10.1128/JB.00171-11. Epub 2011 Mar 18.