Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000593.1:
Cluster 1RiPP16678

BGC0000593, microviridin B biosynthetic gene cluster from Microcystis aeruginosa. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: microviridin J
SMILES string: Copy to clipboard
Molecular formula: C80H105N19O22
Exact molecular mass: 1684.8038 Da (Molecular ion)
Molecular activity: Inhibitor
Molecular target: trypsin and chymotrypsin proteases

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
Microviridin (cyclic)
Peptides in this cluster:
CAQ16121
RiPP core peptide sequence(s): MAYPNDQQGKALPFFARFLSVSKEESSIKSPSPDHEISTRKYPSDWEEW
Leader peptide length: 36
Follower peptide length: -1
Recognition motif in leader peptide for modification: pffarfl
Peptidase(s) involved in precursor cleavage:
Crosslinks in final product:
3=9 AA (Lactone)
8=11 AA (Lactone)
5=13 AA (Lactam)

Gene cluster description

microviridin B (BGC0000593). Gene Cluster 1. Biosynthetic class = RiPP. GenBank AM943878. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Nadine Ziemert (University of Tuebingen)

Literature references

1. Ziemert N et al. (2008 TI) Ribosomal synthesis of tricyclic depsipeptides in bloom-forming cyanobacteria. Angew Chem Int Ed Engl 47(40):7756-9. doi: 10.1002/anie.200802730.
2. Rohrlack T et al. (2003) Isolation, characterization, and quantitative analysis of Microviridin J, a new Microcystis metabolite toxic to Daphnia. J Chem Ecol 29(8):1757-70.