LOCUS       BGC0000595             21771 bp    DNA     linear   CON 03-AUG-2016
DEFINITION  Streptomyces coelicolor A3(2) chromosome, complete genome.
ACCESSION   BGC0000595
VERSION     BGC0000595
KEYWORDS    .
SOURCE      Streptomyces coelicolor A3(2)
  ORGANISM  Streptomyces coelicolor A3(2)
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces; Streptomyces albidoflavus group.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645882.
            On Jun 22, 2003 this sequence version replaced NC_003888.2.
            RefSeq Category: Reference Genome
            MOD: Model Organism
            UPR: UniProt Genome
            COMPLETENESS: full length.
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 19:58:29
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 21771
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..21771
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000595"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..21771
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..1407
                     /db_xref="GeneID:1097872"
                     /gene_synonym="SCC24.09"
                     /locus_tag="SCO2438"
     CDS             1..1407
                     /codon_start=1
                     /db_xref="GeneID:1097872"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1246:monooxygenase FAD-binding (Score: 420.3; E-value:
                     1.5e-127)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCC24.09"
                     /locus_tag="SCO2438"
                     /note="SCC24.09, possible hypothetical protein, len: 468
                     aa; similar to various hypothetical proteins, e.g.
                     TR:O86550 (EMBL:AL031350) Streptomyces coelicolor
                     hypothetical 50.7 kD protein SC1F2.13c, 476 aa; fasta
                     scores: opt: 931 z-score: 995.7 E(): 0; 43.2% identity in
                     458 aa overlap. Contains possible N-terminal region signal
                     peptide sequence"
                     /product="hypothetical protein"
                     /protein_id="NP_626681.1"
                     /transl_table=11
                     /translation="MSRRAVVVGAGLAGMLAAAVLANAGVAEVVVLDRDELPDGPRQRR
                     GLPQGRHAHLLMPGGLTAMEEIVPGASLRGRLLAAGAHEVSLGSGMLARSPEGWLRRWR
                     RPGPVMLTCTRALVDWTVRAAVLEQTAVEVRRASVVGLTGSSGRVRGVRVSGPGGEEDL
                     DADLVVDASGRGTRIIPWLDGLGLSGVRTRTVDSGLVNASRVYRVPAGAERFPLTVVHA
                     DPYVSRPGRSAMVMPIEGDRWLVSCGGTRGGEPPADPEGFLRYTLGLPDPIVGRLISGA
                     EPLTDVHLSRSTSNVRHYLDKVRDWPEGLVVLGDALGTFNPAYGQGMSVAAFGARVLGQ
                     ELDRAGGLDAPGLARRVLRGAARPVDAAWAMAVGQDVLYPGTRGGGRPGIADRAATAYT
                     RRMTRAATGSLAAASAIWDVTSMRTPPTRLFHPSAVLAALAGPPLPLLTGPPLTPGERE
                     VLDGLDRTGA"
     gene            complement(1465..2325)
                     /db_xref="GeneID:1097873"
                     /gene_synonym="SCC24.10c"
                     /locus_tag="SCO2439"
     CDS             complement(1465..2325)
                     /codon_start=1
                     /db_xref="GeneID:1097873"
                     /gene_synonym="SCC24.10c"
                     /locus_tag="SCO2439"
                     /note="SCC24.10c, possible calcium-binding protein, len:
                     286 aa; similar to TR:BAA90694 (EMBL:AB037936) Xenopus
                     laevis regucalcin, 299 aa; fasta scores: opt: 449 z-score:
                     514.7 E(): 3.1e-21; 33.8% identity in 293 aa overlap"
                     /product="calcium-binding protein"
                     /protein_id="NP_626682.1"
                     /transl_table=11
                     /translation="MKRTGTAFEVAVHEEATLGEGPTWDPATGRLLWLDILNSRVHTHD
                     PATGRRTVRRTDQHVGAVKPRAGGGLVLNLRDGIGLLDPDDTFRWLHREPVPGRRGNDA
                     AVAPDGSLWAGTMRYDEARGGGTLTRCTGDGTAETVLDDVTVSNGTGWSPDGTLMYYAD
                     TPTRRIDVFDVTADGRVAGRRPLAAIEDGAGFPDGLCVDADGCVWVALWDGGAVRRYTP
                     SGELDRVITLPVPRVTACAFGGPDLTDLYLTTARVGLPDPHPLAGSLLVVPDAGRGVAQ
                     PAFAG"
     gene            complement(2322..3095)
                     /db_xref="GeneID:1097874"
                     /gene_synonym="SCC24.11c"
                     /locus_tag="SCO2440"
     CDS             complement(2322..3095)
                     /codon_start=1
                     /db_xref="GeneID:1097874"
                     /gene_functions="regulatory (smcogs) SMCOG1195:IclR family
                     transcriptional regulator (Score: 250.5; E-value: 2.2e-76)"
                     /gene_kind="regulatory"
                     /gene_synonym="SCC24.11c"
                     /locus_tag="SCO2440"
                     /note="SCC24.11c, probable transcriptional regulator, len:
                     257 aa; similar to SW:KDGR_ECOLI (EMBL:AE000277)
                     Escherichia coli transcriptional regulator KdgR, 263 aa;
                     fasta scores: opt: 446 z-score: 510.4 E(): 5.4e-21; 32.1%
                     identity in 249 aa overlap. Contains Pfam match to entry
                     PF01614 IclR, Bacterial transcriptional regulator"
                     /product="transcriptional regulator"
                     /protein_id="NP_626683.1"
                     /transl_table=11
                     /translation="MGRLVPAVTRALDILELFLDGDGTLSAPDIVRRLQLPRTTVHELV
                     TTLAARKYIVPVAGQSGRYRLGVRPYQLGARYAEYLDLAAEGQQVARTVAETCDETVHV
                     AILEDTDVIYIAKVDSTHAVRMVSAAGRRLPAHCTSVGKMLLASLPEPEVAARFPDGAE
                     LTAMTPNSITDPAALREALAAIRERGTAVESRESNPDVSCVAAPVRDRTGRVVAALSIS
                     VPMIRWSEERRAELEQLAVKGAADLSERLGHRSAA"
     regulatory      complement(2332..2336)
                     /gene_synonym="SCC24.11c"
                     /locus_tag="SCO2440"
                     /regulatory_class="ribosome_binding_site"
     misc_feature    complement(2346..2906)
                     /gene_synonym="SCC24.11c"
                     /locus_tag="SCO2440"
                     /note="Pfam match to entry PF01614 IclR, Bacterial
                     transcriptional regulator, score 190.70, E-value 2.4e-53"
     regulatory      complement(3105..3109)
                     /regulatory_class="ribosome_binding_site"
     gene            3222..3824
                     /db_xref="GeneID:1097875"
                     /gene_synonym="SCC24.12"
                     /locus_tag="SCO2441"
     CDS             3222..3824
                     /codon_start=1
                     /db_xref="GeneID:1097875"
                     /gene_synonym="SCC24.12"
                     /locus_tag="SCO2441"
                     /note="SCC24.12, unknown, len: 200 aa. High content in
                     alanine and arginine residues"
                     /product="hypothetical protein"
                     /protein_id="NP_626684.1"
                     /transl_table=11
                     /translation="MMAAMPTGKRPAGPFTPRDFQLVLLRRMADHNPGPVEDARRELGA
                     SVAQMREANRRWQAMLRSPRSRSAAARYRSVLGEPESVAPRRIGDLECEARQWALPLWP
                     GLRFEVLVADRGVVWNEWLVRAPGAPGPELRTLDDLTPWSCTVDEAARAFAPARPLQGS
                     APTRWGLAFTAPDREGVRHEVVAEFTWGLLQRTAVGG"
     gene            complement(3849..4556)
                     /db_xref="GeneID:1097876"
                     /gene_synonym="SCC24.13c"
                     /locus_tag="SCO2442"
     CDS             complement(3849..4556)
                     /codon_start=1
                     /db_xref="GeneID:1097876"
                     /gene_functions="regulatory (smcogs) SMCOG1071:GntR family
                     transcriptional regulator (Score: 161.1; E-value: 5.6e-49)"
                     /gene_kind="regulatory"
                     /gene_synonym="SCC24.13c"
                     /locus_tag="SCO2442"
                     /note="SCC24.13c, probable gntR-family transcriptional
                     regulator, len: 235 aa; similar to SW:UXUR_ECOLI
                     (EMBL:U14003) Escherichia coli, Uxu operon transcriptional
                     regulator UxuR, 257 aa; fasta scores: opt: 338 z-score:
                     385.5 E(): 4.9e-14; 32.6% identity in 236 aa overlap and to
                     TR:CAB6127 (EMBL:AL132991) Streptomyces coelicolor
                     transcriptional regulator SCF55.06, 253 aa; fasta scores:
                     opt: 380 z-score: 432.1 E(): 1.2e-16; 33.1% identity in 236
                     aa overlap. Contains Pfam match to entry PF00392 gntR,
                     Bacterial regulatory proteins, gntR family and match ot
                     Prosite entry S00043 Bacterial regulatory proteins, gntR
                     family signature and possible helix-turn-helix motif at
                     residues 37..58 (+3.83 SD)"
                     /product="GntR family transcriptional regulator"
                     /protein_id="NP_626685.1"
                     /transl_table=11
                     /translation="MTDALRPMTKQRLYEQVLERLRQYVADGGLRAGDRLPPERDLAQR
                     LGVSRASVKQAIVVLEVQGLVEARHGGGTYLVRDSLDVEPVEKMVERRRRLPDVLEARE
                     ALETKLAELAAERRTEDDLAAMRSALAVMAEEIDRDGHGVEGDRLFHAAVTAAAHSSLL
                     AEFMRSIAHQIAESRTESLRQPGRPGRSLAQHRAILDAVAARQPRQAAAAMRRHVRTVA
                     KVRLLDWDPEDER"
     misc_feature    complement(4329..4508)
                     /gene_synonym="SCC24.13c"
                     /locus_tag="SCO2442"
                     /note="Pfam match to entry PF00392 gntR, Bacterial
                     regulatory proteins, gntR family, score 82.80, E-value
                     4.9e-24"
     misc_feature    complement(4377..4451)
                     /gene_synonym="SCC24.13c"
                     /locus_tag="SCO2442"
                     /note="PS00043 Bacterial regulatory proteins, gntR family
                     signature"
     regulatory      complement(4566..4571)
                     /regulatory_class="ribosome_binding_site"
     stem_loop       4607..4715
                     /note="13806 GTGGCCGAGTGGCTGAGCCAATTGT 13830-13890
                     ACAAGTGGCTCAGCCACTCGGCCAC 13914. 24/25 (96%) matches, 0
                     gaps"
     regulatory      4755..4758
                     /regulatory_class="ribosome_binding_site"
     gene            4766..6163
                     /db_xref="GeneID:1097877"
                     /gene_synonym="SCC24.14"
                     /locus_tag="SCO2443"
     CDS             4766..6163
                     /codon_start=1
                     /db_xref="GeneID:1097877"
                     /gene_synonym="SCC24.14"
                     /locus_tag="SCO2443"
                     /note="SCC24.14, probable carrier protein (membrane
                     protein), len: 465 aa; similar to TR:Q9ZIP4 (EMBL:AF022387)
                     Rhizobium trifolii dicarboxylate carrier protein gene MatC,
                     448 aa; fasta scores: opt: 827 z-score: 814.6 E(): 0; 51.0%
                     identity in 465 aa overlap. Contains possible hydrophobic
                     membrane spanning regions"
                     /product="hypothetical protein"
                     /protein_id="NP_626686.1"
                     /transl_table=11
                     /translation="MSPELISILVLVVVFVIATTRSVNMGALAFAAAFGVGTLVADLDA
                     DGIFAGFPGDLFVVLVGVTYLFAIARANGTTDWLVHAAVRLVRGRVALIPWVMFALTGA
                     LTAIGAVSPAAVAIVAPVALSFATRYSISPLLMGTMVVHGAQAGGFSPISIYGSIVNGI
                     VEREKLPGSEIGLFLASLVANLLIAAVLFAVLGGRKLWARGAVTPEGDGAPGKAGTGTT
                     GSGSDTGTGTGTGTGTSAGTGGTAPTAVAVRSDRETGGAEGTGVRLTPARVATLVALVA
                     LVVAVLGFDLDAGLTAVTLAVVLSTAWPDDSRRAVGEIAWSTVLLICGVLTYVGVLEEM
                     GTITWAGEGVGGIGVPLLAAVLLCYIGAIVSAFASSVGIMGALIPLAVPFLAQGEIGAV
                     GMVAALAVSATVVDVSPFSTNGALVLAAAPDVDRDRFFRQLMVYGGIVVAAVPALAWLV
                     LVVPGFG"
     repeat_region   5420..5479
                     /gene_synonym="SCC24.14"
                     /locus_tag="SCO2443"
                     /note="degenerate repeat 10x (G/T/D)(T/S/G)"
     regulatory      6239..6242
                     /regulatory_class="ribosome_binding_site"
     gene            6251..7708
                     /db_xref="GeneID:1097878"
                     /gene_synonym="SCC24.15"
                     /locus_tag="SCO2444"
     CDS             6251..7708
                     /EC_number="2.3.1.86"
                     /NRPS_PKS="Domain: AMP-binding (15-390). E-value: 6.4e-85.
                     Score: 277.0. Matches aSDomain:
                     nrpspksdomains_SCO2444_AMP-binding.1"
                     /codon_start=1
                     /db_xref="GeneID:1097878"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     350.5; E-value: 2.1e-106)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCC24.15"
                     /locus_tag="SCO2444"
                     /note="activates fatty acids by binding to coenzyme A"
                     /product="acyl-CoA synthetase"
                     /protein_id="NP_626687.1"
                     /transl_table=11
                     /translation="MSSLFPALSPAPTGAPADRPALRFGERSLTYAELAAAAGATAGRI
                     GGAGRVAVWATPAMETGVAVVAALLAGVAAVPLNPKSGDKELAHILSDSAPSLVLAPPD
                     AELPPALGALERVDVDVRARGAVPEDGADDGDPALVVYTSGTTGPPKGAVIPRRALATT
                     LDALADAWQWTGEDVLVQGLPLFHVHGLVLGILGPLRRGGSVRHLGRFSTEGAARELND
                     GATMLFGVPTMYHRIAETLPADPELAKALAGARLLVSGSAALPVHDHERIAAATGRRVI
                     ERYGMTETLMNTSVRADGEPRAGTVGVPLPGVELRLVEEDGTPIAALDGESVGEIQVRG
                     PNLFTEYLNRPDATAAAFTEDGFFRTGDMAVRDPDGYVRIVGRKATDLIKSGGYKIGAG
                     EIENALLEHPEVREAAVTGEPDPDLGERIVAWIVPADPAAPPALGTLADHVAARLAPHK
                     RPRVVRYLDAVPRNDMGKIMKRALNRD"
     aSDomain        6296..7420
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCO2444_AMP-binding.1"
                     /evalue="6.40E-85"
                     /label="SCO2444_AMP-binding.1"
                     /locus_tag="SCO2444"
                     /protein_end="390"
                     /protein_start="15"
                     /score="277.0"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="PADRPALRFGERSLTYAELAAAAGATAGRIGGAGRVAVWATPAME
                     TGVAVVAALLAGVAAVPLNPKSGDKELAHILSDSAPSLVLAPPDAELPPALGALERVDV
                     DVRARGAVPEDGADDGDPALVVYTSGTTGPPKGAVIPRRALATTLDALADAWQWTGEDV
                     LVQGLPLFHVHGLVLGILGPLRRGGSVRHLGRFSTEGAARELNDGATMLFGVPTMYHRI
                     AETLPADPELAKALAGARLLVSGSAALPVHDHERIAAATGRRVIERYGMTETLMNTSVR
                     ADGEPRAGTVGVPLPGVELRLVEEDGTPIAALDGESVGEIQVRGPNLFTEYLNRPDATA
                     AAFTEDGFFRTGDMAVRDPDGYVRIVGRKATDLIK"
     misc_feature    6338..7498
                     /gene_synonym="SCC24.15"
                     /locus_tag="SCO2444"
                     /note="Pfam match to entry PF00501 AMP-binding, AMP-binding
                     enzyme, score 144.50, E-value 1.9e-39"
     CDS_motif       6662..6718
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SCO2444_0001"
                     /evalue="9.50E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="SCO2444"
                     /protein_end="156"
                     /protein_start="137"
                     /score="21.3"
                     /tool="antismash"
                     /translation="ALVVYTSGTTGPPKGAVIP"
     misc_feature    6668..6703
                     /gene_synonym="SCC24.15"
                     /locus_tag="SCO2444"
                     /note="PS00455 AMP-binding domain signature"
     CDS_motif       7247..7324
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SCO2444_0002"
                     /evalue="1.10E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="SCO2444"
                     /protein_end="358"
                     /protein_start="332"
                     /score="27.4"
                     /tool="antismash"
                     /translation="VGEIQVRGPNLFTEYLNRPDATAAAF"
     gene            7701..9077
                     /db_xref="GeneID:1097879"
                     /gene_synonym="SCC24.16"
                     /locus_tag="SCO2445"
     CDS             7701..9077
                     /codon_start=1
                     /db_xref="GeneID:1097879"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059:acetyl-CoA carboxylase, carboxyl transferase,
                     (Score: 246.5; E-value: 9.8e-75)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCC24.16"
                     /locus_tag="SCO2445"
                     /note="SCC24.16, probable acetyl CoA carboxylase (alpha and
                     beta subunits), len: 458 aa; N-terminal region similar to
                     SW:ACCD_ECOLI (EMBL:M32445) Escherichia coli
                     acetyl-Coenzyme A carboxylase carboxyl transferase subunit
                     beta (EC 6.4.1.2) AccD, 304 aa; fasta scores: opt: 368
                     z-score: 366.2 E(): 5.8e-13; 32.4% identity in 238 aa
                     overlap and C-terminal region similar to TR:AAF10787
                     (EMBL:AE001970) Deinococcus radiodurans acetyl-CoA
                     carboxylase carboxyl transferase alpha subunit DR1214, 316
                     aa; fasta scores: opt: 366 z-score: 364.0 E(): 7.7e-13;
                     39.9% identity in 223 aa overlap"
                     /product="acetyl CoA carboxylase subunits alpha/beta"
                     /protein_id="NP_626688.1"
                     /transl_table=11
                     /translation="MTERLTAREFLALVTDDATFSELPHADGPWRPDGPLGWPGYDASR
                     ARAAERTGEAESVVCGTGLVEGTRAVLVSFEFGFLGGSLGHRTGDRLEAAYAYAREHRL
                     PVVPLVATGGSRMQEGMLALTQLQRVARQSALTRAAGLAQIAVVRDPATGGGWATLGAG
                     ADVVLALPGAQVGFAGSRVRPPDADPAAYTAEAQVAAGSADAVVPPGELRATLGRWLRL
                     LTAPSGGPAPVPEPLGARDLPAGGWEAVRRARDPGRPRAGAYLDAYFTDRVALSGDRCG
                     GRDPEGMLCGFGSHAGRTVAYAAQTGTATRPAGYRTATRLIHLADRLGIPVLTLVDTPG
                     AANDAEAERAGAGPAIADLFGAVASARTPVTTLVIGEGGSGGALALAAPGSTWATPDSY
                     FSVIAPEHAAAILKRPPAEVEATAGQLRLRPQDLAALGVIRTSEQLFPGTGDRRSEERM
                     "
     gene            complement(9346..13008)
                     /db_xref="GeneID:1097880"
                     /gene_synonym="SCC24.17c"
                     /locus_tag="SCO2446"
     CDS             complement(9346..13008)
                     /codon_start=1
                     /db_xref="GeneID:1097880"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 265.2; E-value: 2.3e-80)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SCC24.17c"
                     /locus_tag="SCO2446"
                     /note="SCC24.17c, probable peptidase, len: 1220 aa; similar
                     to TR:P95684 (EMBL:D83672) Streptomyces albogriseolus
                     subtilisin-like protease, 1102 aa; fasta scores: opt: 1362
                     z-score: 1378.8 E(): 0; 33.7% identity in 1233 aa overlap
                     and to TR:CAB56662 (EMBL:AL121596) Streptomyces coelicolor
                     probable peptidase SCF51A.10, 1245 aa; fasta scores: opt:
                     1509 z-score: 1527.2 E(): 0; 39.5% identity in 1278 aa
                     overlap. Contains Pfam match to entry PF00082 Peptidase_S8,
                     Subtilase family and matches to Prosite entries PS00136
                     Serine proteases, subtilase family, aspartic acid active
                     site, S00137 Serine proteases, subtilase family, histidine
                     active site and PS00138 Serine proteases, subtilase family,
                     serine active site. Contains also possible N-terminal
                     region signal peptide sequence"
                     /product="peptidase"
                     /protein_id="NP_626689.1"
                     /transl_table=11
                     /translation="MSTGPVRRGAALLSAGLVIALLPAGTSAAQDPPPDPARSRTAAAR
                     TAAADAARTVTLVTGDRVTVTDLGGGRKTVAVERPEGATGAVRTSSFGGRTTVVPDEAL
                     PYLRDGSLDERLFDVGALLEQGLADSETGELPLIVTYGKGVRAATPRGAERTRSLPSVR
                     GAAVEADKGRAFWREFTRRGAGVEGVWLDGRVTADMAESNAQIGTPEAWEAGLTGKGVT
                     VAVLDSGVDAGHPDLAGRIAQSRSFIPGEEVADRHGHGTHVTSTVGGSGAASDGKEKGV
                     APGATLAVGKVLDDEGFGSESEIIAGMEWAARDVDADIVSMSLGSTEPSDGTDPMAEAV
                     NTLSRETGALFVIAAGNTGAPSSIGSPGAADAALTVGAVDSADQAAWFTSAGPRYGDNA
                     LKPDLSAPGVGILAARSRLAEGSGDYTSMDGTSMATPHIAGVAALLAEEHPDWSGARLK
                     DALMSTSKELDVSAYQLGAGRVSVPAAVGADVTATGSADLGFYSWPYEADEPVTRTVAY
                     TNSSDTDVELKLSVRGAPEGVATLADTSLTVPAHGTASTTVTGDGSKAPVGDTSGQVVA
                     ADASGKPLAHTAFGLVKEGERYTLTVHVKDRSGAATPADLTVQRLTEGVDPFPAHVGDS
                     GTLKLRLEPGTYSLSSFLDVRGSHGADSLGLGFLAAPEVVVDRDREITLDGRELREIGA
                     DVGRRTETRQLLMEYDRGANGSDLFGAVQVPLTYDSVFAAPTKKVAQGDFEYRTVWRLG
                     KPLLEVKGIDEATVQSGGTLTEGRTRLPLVDVGAVGAGPFPDGVRGKAVLARLTEGTEP
                     AALAQAAQDAGVKVLFVTDDAPGRLMSWWGTDDNADRPLQIATVSAADARRLHRAGRVD
                     MTGTRNTPYVYDLSEGHEGAVPDRDLTYEPGHRDLAVLRTRYHAAEPSSGGEFRYSLTD
                     TFPIGLGFRERIDYPVERTEYVSTGPGQLWHETVTSAGEALEERGGLSRYRGGSRAELN
                     WFKPVWHPYLGTGLGWGQQRAGNRLQFNAPGWGDSGPDHTGFGDVWSEGSGMSQTTSVY
                     LDGEPVDQGPSSAAYVWDAPADEHTYRLVTDTALDAARWPLATKGHAEWTFRSAATPDD
                     RWTFLPLINLSFDVDTDLAGKVRAGKKLRIGLGAAYVAGAPDTGKLGGGKLEASYDGGT
                     TWHQVRLRGGDGEASWYGTLSVPRDAEHVSLRASARDDRGGSVTQEIVRAVAVR"
     misc_feature    complement(11542..12420)
                     /gene_synonym="SCC24.17c"
                     /locus_tag="SCO2446"
                     /note="Pfam match to entry PF00082 Peptidase_S8, Subtilase
                     family, score 200.10, E-value 3.3e-56"
     misc_feature    complement(11689..11721)
                     /gene_synonym="SCC24.17c"
                     /locus_tag="SCO2446"
                     /note="PS00138 Serine proteases, subtilase family, serine
                     active site"
     misc_feature    complement(12202..12234)
                     /gene_synonym="SCC24.17c"
                     /locus_tag="SCO2446"
                     /note="PS00137 Serine proteases, subtilase family,
                     histidine active site"
     misc_feature    complement(12307..12342)
                     /gene_synonym="SCC24.17c"
                     /locus_tag="SCO2446"
                     /note="PS00136 Serine proteases, subtilase family, aspartic
                     acid active site"
     gene            13187..13648
                     /db_xref="GeneID:1097881"
                     /gene_synonym="SCC24.18"
                     /locus_tag="SCO2447"
     CDS             13187..13648
                     /codon_start=1
                     /db_xref="GeneID:1097881"
                     /gene_synonym="SCC24.18"
                     /locus_tag="SCO2447"
                     /note="SCC24.18, unknown, len: 153 aa"
                     /product="hypothetical protein"
                     /protein_id="NP_626690.1"
                     /transl_table=11
                     /translation="MVLRTDTYGTRGASGVMDGLVEFRTEDGVRVVVEGVEDEDGARLV
                     SRGDGPARAARTFEDSLDGVRAAAASALRVFRDGSLRPDAVELEFGVKLSAEAGAVIAK
                     GSAEGHLVVRLNWSPEPSPTRTEPQPSATRPEPRPSPAGPEAPDAVALS"
     gene            13645..15309
                     /db_xref="GeneID:1097882"
                     /gene_synonym="SCC24.19"
                     /locus_tag="SCO2448"
     CDS             13645..15309
                     /codon_start=1
                     /db_xref="GeneID:1097882"
                     /gene_synonym="SCC24.19"
                     /locus_tag="SCO2448"
                     /note="SCC24.19, unknown, len: 554 aa"
                     /product="hypothetical protein"
                     /protein_id="NP_626691.1"
                     /transl_table=11
                     /translation="MSGAAWHARVECGREVGAGFLVSARRLLTCAHVVRWADRAPVTVT
                     FPGRRELGELSGTVVVHGGWQEGAADLGDLVVLELDREVPLAPAVFARPGTERTVPVPE
                     LIAYGFPKGYDEGMLASYRALPGPLISDEWVQLEAVTAHGQPLAAGFSGAALTLADGTV
                     VGMVSAVAGARDVRVGRMLPVEVMARYWPELGELVPTPGHRADARRRLYALVRRAEESG
                     LDCDPNRLYVSAMDAFDPPLPEGGFGSLREAAAYVQWEVPDPAAVARFADRLTERLHAP
                     SGPAPRPAAWSPIVVEIDRSGAGADQVTVEVSAYRDGRRRPVGSRRLARGAVRSFVQEG
                     IDEAFTQLDPGADELLTFVLPREWLNEPVAHWECGEDDSTPLGCAYPLVVTDRYRHRSG
                     RLRHQLHKKWRRLGSGTGGTLHRVDCGTRERPAGLRKRLRDDAELAGFATPPSAAPEYF
                     EVGLNLPVPVLLWPLRECPGEEGPDGRCSGTAFLDELAASVADVPPAELPRLVMELRET
                     ADAAEVPEEHWARDVQLLWDDPRCFAEPPALLHSPVG"
     regulatory      15434..15439
                     /regulatory_class="ribosome_binding_site"
     gene            15448..16470
                     /db_xref="GeneID:1097883"
                     /gene_synonym="SCC24.20"
                     /locus_tag="SCO2449"
     CDS             15448..16470
                     /codon_start=1
                     /db_xref="GeneID:1097883"
                     /gene_synonym="SCC24.20"
                     /locus_tag="SCO2449"
                     /note="SCC24.20, conserved hypothetical protein, len: 340
                     aa; similar to TR:Q9F3J5 (EMBL:AL391763) Streptomyces
                     coelicolor conserved hypothetical protein 340 aa; fasta
                     scores: opt: 1113 Z-score: 1094.9 E(): 2.4e-53; 54.519%
                     identity in 343 aa overlap"
                     /product="hypothetical protein"
                     /protein_id="NP_626692.1"
                     /transl_table=11
                     /translation="MPLWPVYTGAPDPHDGIARLPPPPPWRAFDGGPVLDPPDADGDTA
                     AASPDRAHRAATYQATEDTVQLVNAALYLRRPLLVTGPPGTGKSSLAYAVARELRLGPV
                     LRWNITSRSTLGDGLYTYDPLSRLYAARHTTQPPDAPAATGVEDHLRLGPLGTALLPYA
                     RPRALLIDEIDKSDLDLPNDLLHVLEEGQYEIPELVRASRDIPDGHAEVLADGTDQRVP
                     VERGRVRCNAFPFVVLTSNGEREFPPAFLRRCVSLRLRQPDDDHLAEIVRAHLGEPDGH
                     ARQLIHRFLSRVGSGELATDQLLNAIYLARSSGLGADSLDELAEQLMPYLGRSAQSDAF
                     "
     gene            16470..20519
                     /db_xref="GeneID:1097884"
                     /gene_synonym="SCC24.21"
                     /locus_tag="SCO2450"
     CDS             16470..20519
                     /codon_start=1
                     /db_xref="GeneID:1097884"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 67.6;
                     E-value: 2.1e-20)"
                     /gene_kind="regulatory"
                     /gene_synonym="SCC24.21"
                     /locus_tag="SCO2450"
                     /note="SCC24.21, possible Ser/Thr protein kinase
                     (regulator), len: 1349 aa; N-terminal region similar to
                     SW:PKAB_STRCO (EMBL:D86821) Streptomyces coelicolor Ser/Thr
                     protein kinase PkaB, 417 aa; blastp socres: Score = 109
                     (38.4 bits), Expect = 0.00070, Sum P(2) = 0.00070
                     Identities = 39/121 (32%), Positives = 60/121 (49%) and
                     C-teminal region similar to SW:AFSR_STRCO (EMBL:D90155)
                     Streptomyces coelicolor regulatory protein AfsR, 993 aa;
                     fasta scores: opt: 510 z-score: 438.0 E(): 5.8e-17; 33.3%
                     identity in 442 aa overlap. Contains Pfam match to entry
                     PF00069 pkinase, Eukaryotic protein kinase domain"
                     /product="Ser/Thr protein kinase (regulator)"
                     /protein_id="NP_626693.1"
                     /transl_table=11
                     /translation="MPTDRPGTPDPPPLPLLADLLGRAATGARPTPLELAELLWLAGHM
                     EPPEQDPPDGPASGTRPAEPPPAPEGTREQGQEGDGQRERDRKPERDRHGDRERDRDGD
                     RDRGPGRGPWGDGPGRPSTRSEAPRTPLRLPSPAPAPGTSAAQPHSALLAPAPPMLRHT
                     LALQRALRPLKRRADAPVGHEVDEAATADRIARLGAGPEWWLPVLRPVRERWLRLHLVH
                     DAGPTMPVWRPLVRELQAALAQSGVFRTVTLHRADPDGTVRGDGAQIPADGRTVMLLIS
                     DCMGPQWRAGPDGVRWFATLRRWARRAPLAVLQPLPEQLWRDTALPPVPGRLSAPHRAA
                     PSASLAFTPYDTAAPRAPEGTVHVPVLEPGPEWLANWAALVASPGGTPYPGAAAALHRP
                     LPADADDRTDVARLSPEELVLRFRASASPQAYRLAGHLALGRPDLPVMRLVQAAVEPDP
                     RPQHLAEVILGGLLTTVAGPPGSYAFRPGVRELLLRGLPRTARNRTHDLLLRTGGLIDD
                     RAGRSPGEFRALIPSRKGTERAGPSESFATISEESVRQLTVRERPSAPSPFPPGLGARY
                     RPTRRLTPSGRIWLAEDTGPDRTAPDRTPADRTAAHPVPTNRTVAIRLHDPATGPAARQ
                     TFLRNARRLTRLSHPNLVTVLDAGIEGDVPYVVMEHLDGIALGALTRSGDGRLPVPLTV
                     SVGAQLARALTALHRAGLAHGGLEASRVVLLPDGTVRLSLFEPALALGPGARSADLRAL
                     CEVLLRLTSGTSRPAVPVDSRRLHRLPTALRIHYAHAFDQLLSPSPAAQARGLDLLGDP
                     ALLARAGEAYAPRRYRALGPLRVGLPDGPADLPRDVRALLAMLLLKHGRTVTHEELRWG
                     LWDPGNEPRNPRSETTRLAKRLAEILGPGVLATAAHGYALHTSADELDLVRCDELVRRA
                     DAARLEGALAEAHDLVSGALSLWGDAEPLAGVPGPAARTARTRLLRLRLALHTKRAELD
                     LVLGEYDRAAAELSGLLRAHPHREDFRRLCLIALRRQGRVEEALEVYEEYELSGGRSPA
                     LTALGRELREEYAEPVDDAPPWTEYEQRPVEPGAPESTVSAPDELPEGPFPTEDGLWTP
                     LLDDDAEHDTAQARAEADEREERAESRAALREAMRAEGLEPEPELDEDPGPEEEEEPDE
                     PPWIDFDTGFRACARYTLADGPVDRDARAALHGLVTELLADSGADAAAYELVDEPGGPL
                     VLLAPRAEAAPLLRATVEGLPGRLARLAGLRLRIEFWQVEFGLDGNGEQSLGRADADAV
                     GAVLDASAAQAVVVLSDSLYYDEVREEGQYGPAFPPDLFRPLADDTGWYHLVEGGGRPG
                     PAADLR"
     misc_feature    18399..18611
                     /gene_synonym="SCC24.21"
                     /locus_tag="SCO2450"
                     /note="Pfam match to entry PF00069 pkinase, Eukaryotic
                     protein kinase domain, score 28.50, E-value 8.3e-07"
     regulatory      20677..20682
                     /regulatory_class="ribosome_binding_site"
     gene            20689..21771
                     /db_xref="GeneID:1097885"
                     /gene_synonym="SCC24.22"
                     /locus_tag="SCO2451"
     CDS             20689..21771
                     /codon_start=1
                     /db_xref="GeneID:1097885"
                     /gene_synonym="SCC24.22"
                     /locus_tag="SCO2451"
                     /note="SCC24.22, probable rod shape-determining protein,
                     len: 360 aa; similar to SW:MREB_BACSU (EMBL:M95582)
                     Bacillus subtilis rod-shape determining protein MreB, 337
                     aa; fasta scores: opt: 740 z-score: 810.4 E(): 0; 34.8%
                     identity in 322 aa overlap and to TR:CAB75392
                     (EMBL:AL139298) Streptomyces coelicolor rod
                     shape-determining protein MreB, 343 aa; fasta scores: opt:
                     868 z-score: 835.5 E(): 0; 43.1% identity in 320 aa
                     overlap"
                     /product="rod shape-determining protein MreB"
                     /protein_id="NP_626694.1"
                     /transl_table=11
                     /translation="MTASTANTASLEALRRCHFAVDLGAARTRVYVKGAGLVVDQPSAA
                     AVNTRTGALIAVGDFAEKMTGRTPGYIRVVRPVSGGTVVDIEMAQRMLRHLLGDRVRRA
                     LRRKPRLRAAVCTPHDADPLSQRAAIETLVGLGARRVELVDTLIAAAVGCGLPVEQPEA
                     TMIMVCGAHATQVAVLSLGSIVTAVRVPVGGEAVDHAIVQLLRHQHELVLPSQSVRPLQ
                     LALSGNGLTPQGPSSTEIHGRDVATGLARSVRVDTATVRNAIQTPLTAVLDGIGKVLRD
                     CPPDLVADLADRGIMMVGGSALLPGFDQMLRQATGMPVHIAERPDVCAVQGLGSMLEGR
                     VEPLVLHPTTAGSDSHADSD"
ORIGIN
        1 atgtcgcgta gagcagtcgt cgtcggtgcc ggactggccg ggatgctggc cgccgccgtg
       61 ctggcaaacg cgggcgtggc ggaggtcgtc gtgctggacc gcgacgagct gcccgacggg
      121 ccgcggcagc gccggggtct tccgcagggg cggcacgcgc acctgctgat gcccggcggg
      181 ctgacggcga tggaggagat cgtgcccggc gcgagcctgc gggggcgact gctcgccgcg
      241 ggggcgcacg aggtgtccct cggctcgggc atgctggccc gcagccccga gggctggctg
      301 cggcggtggc ggcgcccggg gcccgtcatg ctcacctgca cccgggcgct ggtggactgg
      361 acggtacggg ccgcggtgct cgaacagacg gccgtcgagg tgcgccgggc gtccgtggtg
      421 ggcctgaccg ggtcgtcggg gcgggtgcgg ggcgtgcggg tgtcggggcc cggcggggag
      481 gaggacctgg acgccgacct ggtcgtggac gcgagcggac gcggtacccg gatcatcccc
      541 tggctggacg ggctcgggct gtccggcgtc cggacgcgga ccgtggactc ggggctggtc
      601 aacgcctcgc gcgtgtaccg ggtgccggcc ggggcggagc ggttccctct gacggtggtg
      661 cacgccgatc cgtacgtctc ccggccgggc cgcagcgcca tggtcatgcc gatcgagggc
      721 gaccgctggc tggtcagctg cggcggcacg cgcggcggtg aaccaccggc cgatcccgag
      781 gggttcctgc ggtacacgct cggcctgccg gacccgatcg tgggccggct gatctccggc
      841 gccgaaccgc tcaccgacgt gcacctgagc cggtccacca gcaatgtgcg gcactacctg
      901 gacaaggtgc gcgactggcc ggagggcctg gtggtcctcg gcgacgcgct cggcaccttc
      961 aacccggcct acgggcaggg catgtcggtg gccgcgttcg gcgcccgggt actgggacag
     1021 gagctggacc gggccggcgg gctcgacgcg cccggcctgg cccggcgggt gctgcggggt
     1081 gcggcgcgcc cggtggacgc cgcctgggcc atggccgtcg ggcaggacgt cctgtatccc
     1141 gggacgcgcg gcggcgggcg gccgggcatc gccgaccggg cggcgacggc gtacacgcgg
     1201 cgcatgacga gggcggccac cggttccctc gcggcggcct cggcgatctg ggacgtcacc
     1261 agcatgcgca caccgccgac ccgcctgttc cacccgtcgg cggtcctggc cgcgctcgcc
     1321 gggccgccgc tccccctgct gaccgggccg ccgctgaccc cgggcgagcg cgaggtgctc
     1381 gacgggctgg accgcaccgg ggcgtgagcg cgggccggtc ggcggtcgcc gccgttcgcg
     1441 gcggccgccg gacggcggtg ggcgtcaccc cgcgaacgcc ggctgcgcca ccccccgtcc
     1501 cgcgtccggc accaccagca gggagcccgc cagcgggtgc gggtccggca ggccgacgcg
     1561 ggccgtggtg aggtacaggt cggtgaggtc cgggccgccg aaggcgcagg ccgtgacccg
     1621 ggggacgggg agggtgatca cccggtccag ttcgccggac ggggtgtagc ggcgtaccgc
     1681 gccgccgtcc cacagggcga cccacacgca gccgtcggcg tcgacgcaca ggccgtcggg
     1741 gaagcccgcg ccgtcctcga tcgcggccag ggggcggcgg cccgcgaccc ggccgtccgc
     1801 ggtgacgtcg aagacgtcga tccggcgggt cggggtgtcg gcgtagtaca tgagcgtgcc
     1861 gtcggggctc cagccggtgc cgttgctcac cgtcacgtcg tcgaggacgg tctcggcggt
     1921 gccgtcgccg gtgcaccggg tcagcgtgcc cccgccgcgc gcctcgtcgt agcgcatggt
     1981 gcccgcccac aggctgccgt cgggggcgac ggcggcgtcg ttgccgcggc ggccggggac
     2041 gggttcgcgg tgcagccagc ggaaggtgtc gtcggggtcg agcaggccga tcccgtcccg
     2101 caggttgagg accaggccgc cgcccgcgcg gggcttgacg gcgcccacgt gctggtcggt
     2161 gcggcgcacg gtgcgccggc cggtggccgg gtcgtgggtg tggacgcggg agttcaggat
     2221 gtcgagccac aggaggcggc ccgtggccgg gtcccaggtg gggccctcgc cgagggtcgc
     2281 ctcttcgtgg acggccacct cgaaggccgt gccggtcctt ttcatgccgc gctcctgtgg
     2341 ccgagccgct cggagaggtc ggccgcgccc ttgaccgcga gctgctccag ttcggcgcgg
     2401 cgttcctcgc tccagcggat cataggcacc gagatcgaca gcgcggcgac gacccggccg
     2461 gtgcggtcgc ggaccggggc ggccacgcag gacacgtccg ggttggactc gcggctctcc
     2521 accgccgtac cgcgctcgcg gatcgcggcc agggcctcgc gcagcgcggc cgggtcggtg
     2581 atgctgttcg gggtcatcgc ggtcagctcg gcgccgtcgg ggaagcgcgc ggcgacctcc
     2641 ggctcgggca gggaggccag cagcatcttg ccgacggacg tgcagtgcgc gggcagccgg
     2701 cgtcccgctg cggacaccat gcgcaccgcg tgcgtggagt cgaccttggc gatgtagatg
     2761 acgtcggtgt cctccaggat cgccacgtgc accgtctcgt cgcaggtctc ggcgacggtc
     2821 cgggcgacct gttggccctc cgcggcgagg tcgaggtact cggcgtagcg ggcgccgagc
     2881 tggtacgggc gcacgccgag ccggtaccgt ccggactgcc cggcgaccgg gacgatgtac
     2941 ttgcgggcgg cgagcgtggt gaccagctcg tgcacggtgg tgcgcggcag ctggagcctg
     3001 cgcacgatgt cgggggcgga gagcgtgccg tccccgtcga ggaagagctc cagtatgtcg
     3061 agagcccggg tcacggccgg cacgaggcgt cccatgtcca gccccctccc tagatatgtt
     3121 cgagatttca acaagcgatc ggaataacga acacaggcta ctcataccgc gtttgcctgg
     3181 gcaatgggcg tgcggccgcc ccatggtcca ctgcgtccgc gatgatggct gccatgccga
     3241 ccggaaagcg gcccgcgggc cccttcaccc cgcgcgactt ccagctggtc ctgctgcgcc
     3301 gcatggccga ccacaacccc ggcccggtgg aggacgcccg ccgcgagctg ggcgcctccg
     3361 tcgcgcagat gcgcgaggcc aacaggcgct ggcaggcgat gctgcgctcc ccccggtccc
     3421 gctcggcggc cgctcggtac cgctccgtcc tgggcgagcc ggaatcggtg gcgccgcgcc
     3481 ggatcggcga cctggagtgc gaggcccggc agtgggcgct gcccctgtgg cccggcctgc
     3541 gcttcgaggt gctcgtcgcg gacaggggcg tcgtctggaa cgagtggctg gtccgcgccc
     3601 ccggcgcacc ggggccggaa ctgcgcaccc tggacgacct cacgccctgg tcctgcacgg
     3661 tcgacgaggc ggcccgcgcc ttcgcccccg cccggccgct ccagggctcg gccccgaccc
     3721 ggtgggggct ggccttcacc gccccggacc gggagggcgt acggcacgag gtggtcgcgg
     3781 agttcacctg ggggctgttg cagcgcacgg cggtcggcgg ctgacgcggg ccgggcaggg
     3841 acgggcggtc agcgctcgtc ctccgggtcc cagtccagca gccggacctt ggcgaccgta
     3901 cggacgtggc ggcgcatcgc ggcggcggcc tgccggggct gccgggcggc cacggcgtcc
     3961 aggatcgcgc ggtgctgggc cagggagcgg ccggggcggc cgggctggcg cagggactcg
     4021 gtgcggctct cggcgatctg gtgggcgatg gaccgcatga actcggcgag caggctgctg
     4081 tgtgccgccg cggtcaccgc cgcgtggaag agccggtcgc cctcgacgcc gtgcccgtcc
     4141 cggtcgatct cctcggccat cacggccagc gcggaccgca tggcggcgag gtcgtcctcc
     4201 gtgcggcgct cggcggccag ttcggcgagc ttcgtctcca gggcctcgcg ggcctccagg
     4261 acgtccggga ggcgccggcg gcgttcgacc atcttctcca cgggttcgac gtcgaggctg
     4321 tcccggacca gataggtccc gccgccgtgc cgcgcctcca ccaggccctg cacctccagc
     4381 accacgatcg cctgcttcac cgaggcacgg ctgacaccga ggcgctgggc caggtcccgc
     4441 tcgggcggca gccggtcgcc cgcccgcagg ccgccgtcgg cgacgtactg gcgcagccgc
     4501 tccagcacct gttcgtacag gcgctgtttg gtcatggggc gcagggcgtc ggtcatgagg
     4561 tcccccctct cgacgggagc gtagcaccgg cgccgagggt ggcccggtgg ccgagtggct
     4621 gagccaattg ttgcgcgacc ccttgacgtg atcccgggcc gggcccacgc tgaccagcca
     4681 accgcaccac acaagtggct cagccactcg gccactcgct cagccattcc catcggcagt
     4741 caggtcagca ctcgggagcc cccgcatgtc ccccgaactc atctcgatcc tcgtcctcgt
     4801 cgtggtgttc gtcatcgcca ccacccgctc cgtcaacatg ggcgcgctcg ccttcgccgc
     4861 cgcgttcggg gtgggcacgc tcgtcgccga cctcgacgcg gacggcatct tcgccgggtt
     4921 ccccggcgac ctgttcgtcg tcctggtcgg cgtcacctac ctgttcgcga tcgcccgggc
     4981 caacggcacc accgactggc tggtgcacgc ggccgtccgg ctggtgaggg gccgggtcgc
     5041 gctgatcccc tgggtgatgt tcgcgctgac cggcgcgctc acggcgatcg gcgcggtcag
     5101 cccggccgcg gtcgcgatcg tcgcgccggt cgccctgagc ttcgccaccc ggtactcgat
     5161 cagcccgctg ctcatgggca cgatggtggt gcacggcgcg caggccggcg ggttctcgcc
     5221 gatcagcatc tacggctcga tcgtcaacgg catcgtggag cgggagaagc tcccgggcag
     5281 cgagatcggc ctcttcctcg cctcgctggt cgccaacctc ctcatcgccg ccgtgctgtt
     5341 cgcggtgctc ggcgggcgga agctgtgggc gcgcggggcg gtgacgccgg agggcgacgg
     5401 cgcccccggc aaggccggca ccgggaccac gggcagcggc agcgacaccg gcaccggcac
     5461 cggcaccggc accggtacga gcgcgggcac cggaggcacc gcccccaccg ccgtggccgt
     5521 ccgctccgac cgggagaccg gcggtgccga aggcaccggc gtccgcctca cccccgcccg
     5581 cgtcgccacc ctggtcgccc tggtcgcgct ggtcgtggcc gtgctcggct tcgacctgga
     5641 cgccggtctg accgcggtca ccctcgccgt cgtcctgagc accgcctggc cggacgacag
     5701 ccggcgtgcc gtcggtgaga tcgcctggtc cacggtgctg ctgatctgcg gtgtcctcac
     5761 ctacgtgggc gtactggagg agatgggcac catcacctgg gccggtgagg gcgtcggcgg
     5821 catcggcgtc ccgctgctgg ccgcggtgct gctctgctac atcggcgcga tcgtgtcggc
     5881 cttcgcctcc tccgtgggca tcatgggcgc gctgatcccg ctggcggtgc cgttcctcgc
     5941 gcagggcgag atcggggcgg tcggcatggt ggcggcgctc gcggtgtcgg ccacggtggt
     6001 ggacgtcagc ccgttctcga ccaacggcgc gctggtgctg gccgcggccc cggacgtgga
     6061 ccgggaccgc ttcttccggc agctgatggt ctacggcggg atcgtggtgg cggccgtgcc
     6121 ggcgctggcc tggctcgtgc tggtggtgcc cggcttcggg tagccccgtc tcgcggatcc
     6181 ggcgcgatcc ggcagccttg aacgacagcc ccgacagcag ctctcgggca acagctaagg
     6241 agtacgacgc gtgtcctctc tcttcccggc cctctccccg gccccgaccg gcgccccggc
     6301 cgaccggccc gcgctgcggt tcggcgagcg ctccctgacc tacgcggaac tcgccgcggc
     6361 ggcgggcgcc acggccgggc ggatcggcgg cgccggccgg gtcgcggtct gggccacccc
     6421 ggcgatggag accggcgtcg ccgtggtggc ggcgctgctg gccggggtcg ccgccgtacc
     6481 gctcaacccg aagtccggcg acaaggaact cgcgcacatc ctctccgaca gcgcgccctc
     6541 gctcgtcctg gcgcccccgg acgcggaact cccgcccgcc ctcggggccc tggagcgcgt
     6601 cgacgtcgac gtgcgggccc gcggggcggt ccccgaggac ggtgccgacg acggcgaccc
     6661 cgcgctcgtc gtctacacct cgggcaccac gggaccgccg aagggcgccg tcatcccccg
     6721 gcgggcgctc gccacgaccc tggacgcgct cgccgacgcg tggcagtgga ccggcgagga
     6781 cgtgctggtg caggggctgc cgctgttcca cgtgcacggg ctggtcctcg gcatcctcgg
     6841 cccgctgcgc cggggcgggt ccgtgcggca cctgggccgg ttctccaccg agggtgcggc
     6901 gcgggagctg aacgacggcg cgaccatgct gttcggggtg ccgacgatgt accaccggat
     6961 cgccgagacg ctccccgccg acccggagct ggcgaaggcg ctcgccgggg cccggctgct
     7021 ggtgtcgggg tcggccgcgc tgccggtgca cgaccacgag cgcatcgccg ccgccaccgg
     7081 gcgccgggtg atcgagcggt acggcatgac cgagacgctg atgaacacca gcgtgcgcgc
     7141 cgacggcgag ccgcgcgccg ggacggtggg cgtgccgctg cccggtgtgg agctgcggct
     7201 ggtggaggag gacggcacgc cgatcgcggc gctcgacggg gagagcgtcg gcgagatcca
     7261 ggttcgcggc ccgaacctgt tcaccgagta cctgaaccgc cccgacgcca ccgccgccgc
     7321 cttcaccgag gacggcttct tccgcaccgg cgacatggcg gtgcgcgacc ccgacggcta
     7381 tgtccgcatc gtcggccgca aggccaccga cctgatcaag agcggcggtt acaagatcgg
     7441 ggccggggag atcgagaacg ccctgctcga acacccggag gtccgggagg ccgccgtcac
     7501 cggcgaaccc gaccccgacc tcggggaacg gatcgtggcc tggatcgtcc cggccgaccc
     7561 cgccgccccg cccgccctcg gcacgctggc cgaccacgtc gccgcccggc tcgccccgca
     7621 caagcggccg cgcgtcgtcc ggtacctcga cgcggtgccc cgcaacgaca tggggaagat
     7681 catgaagcgg gcgctgaacc gtgactgagc gcctgaccgc gcgggagttc ctcgccctgg
     7741 tcaccgacga cgccaccttc agcgaactcc cgcacgcgga cggcccgtgg cggcccgacg
     7801 gccccctcgg ctggcccggc tacgacgcct cgcgggctcg cgccgccgag cgcaccggcg
     7861 aggcggagtc cgtcgtctgc ggcaccggcc tggtggaggg cacccgggcg gtgctcgtct
     7921 ccttcgagtt cggcttcctc ggcggctcgc tggggcaccg caccggcgac cgtctggagg
     7981 cggcgtacgc gtacgcccgt gaacaccggc tgccggtggt gccgttggtg gcgaccggcg
     8041 gcagccggat gcaggagggg atgctcgcgc tgacccagct ccagcgggtg gcccggcagt
     8101 cggcgctcac ccgcgcggcc ggcctcgcgc agatcgcggt ggtacgggac ccggcgaccg
     8161 gcggcggctg ggcgacgctg ggcgcgggcg ccgacgtggt cctcgccctg cccggcgccc
     8221 aggtgggctt cgccggttcg cgggtccggc cgccggacgc ggacccggcg gcgtacacgg
     8281 ccgaggcgca ggtggcggcg ggcagcgcgg acgccgtcgt accgcccggg gagctgcgcg
     8341 cgacgctggg gcggtggctg cggctgctga cggcgccgtc cggcggtccg gcgccggtgc
     8401 cggagccgct gggcgcccgg gacctgccgg ccggcggctg ggaggcggtg cgccgggccc
     8461 gcgatcccgg acgcccgcgc gccggggcgt acctggacgc ctacttcacc gaccgcgtcg
     8521 ccctgtccgg cgaccgctgc ggcggccggg acccggaggg catgctgtgc ggcttcggct
     8581 cgcacgcggg gcgcacggtg gcgtacgccg cgcagacggg cacggcgacc cggcccgccg
     8641 ggtaccgcac cgccacccgg ctgatccacc tcgcggaccg gctcggcatc ccggtgctga
     8701 ccctggtgga cacaccgggc gcggccaacg acgcggaggc ggagcgggcg ggggcgggtc
     8761 cggcgatcgc ggacctgttc ggcgccgtgg cctcggcgcg tacgccggtc accacgctgg
     8821 tgatcggcga gggcggctcg ggcggggcgc tggccctggc cgcgcccggc agcacgtggg
     8881 ccaccccgga cagctacttc tccgtcatcg cgccggagca cgcggcggcg atcctgaagc
     8941 gcccgccggc ggaggtggag gcgacggccg gtcaactgcg gctgcggccg caggacttgg
     9001 cagcacttgg cgtgatccga acaagcgagc agttgttccc tggaacaggt gatcgtcgct
     9061 ctgaagaacg catgtgactg cagggaccaa cgatacttac ggtgtgcgag caacgggctg
     9121 cagaccgtag ttgacgcaca tgtcccgagt agtcccggcg gggcccggtg ggtcccgcac
     9181 ctgaacagcg caaggagctg cacgatcatg aaccttctca ccgacatcct cgccggcctc
     9241 gtccacttcg tcggctggct ggtctgacgg tccgagaaac cgacggcgcc gcctccccgt
     9301 cccagggagg cggcgccgtc cgcgtgtccg cgcccggacc ggggcctacc gcacggccac
     9361 cgcccgcacg atctcctgcg tgaccgagcc gccccggtcg tcgcgcgccg aggcccgcag
     9421 cgagacgtgc tcggcatcgc gcggcacgct cagcgtcccg taccaggagg cctccccgtc
     9481 gccgccgcgc agccggacct ggtgccaggt cgtcccgccg tcgtaggacg cctccagctt
     9541 tccgccgccg agcttcccgg tgtccggggc gcccgccacg tacgcggcgc cgagaccgat
     9601 ccgcagcttc ttgccggcgc gcaccttccc cgcgaggtcg gtgtcgacgt cgaaggagag
     9661 gttgatcagc ggcaggaagg tccaccggtc gtcgggcgtg gccgccgacc ggaaggtcca
     9721 ctccgcgtgg cccttcgtcg ccagcggcca gcgtgccgcg tccagcgccg tgtcggtgac
     9781 gagccggtag gtgtgctcgt cggccggcgc gtcccacacg tacgcggcgg aactcggccc
     9841 ctggtcgacc ggttcgccgt ccaggtacac cgacgtggtc tgcgacatgc cgctgccctc
     9901 gctccacacg tcgccgaagc cggtgtggtc gggcccggag tcgccccagc cgggcgcgtt
     9961 gaactggagc cggttcccgg cgcgctgctg cccccagccg agcccggtgc cgaggtaggg
    10021 gtgccacacc ggcttgaacc agttcagctc cgcacgcgag cctccccggt accgggacag
    10081 tccgccgcgc tcctccagcg cctcaccggc gctcgtcacg gtctcgtgcc acagctggcc
    10141 ggggccggtg gacacgtact cggtgcgctc gaccgggtag tcgatccgct cccggaagcc
    10201 gaggccgatc gggaaggtgt cggtgaggga gtaccggaac tcgccgccgc tcgacggttc
    10261 ggcggcgtgg tacctggtgc gcagcacggc gaggtcgcgg tgcccgggct cgtaggtgag
    10321 gtcccggtcg ggcacggcgc cctcgtgtcc ctcggacagg tcgtacacgt agggcgtgtt
    10381 gcgggtgccg gtcatgtcga cccgtccggc ccggtgcagc cggcgggcgt cggccgcgga
    10441 gaccgtggcg atctggagcg gccggtcggc gttgtcgtcc gtgccccacc acgacatcag
    10501 ccgtccgggg gcgtcgtcgg tcacgaacag caccttgacg ccggcgtcct gtgcggcctg
    10561 ggcgagcgcg gccggttcgg tcccctcggt gagccgggcg aggaccgcct tgccgcgtac
    10621 accgtccggg aagggcccgg caccgacggc tccgacgtcg accaggggca gccgggtgcg
    10681 gccctcggtc agggtgccgc cggactggac ggtggcctcg tcgatcccct tcacctcgag
    10741 cagcggcttg ccgagccgcc acacggtgcg gtactcgaag tcgccctggg cgaccttctt
    10801 cgtgggcgcg gcgaagacgc tgtcgtacgt cagcggcacc tgcaccgcgc cgaacaggtc
    10861 ggagccgttc gcgccgcggt cgtactccat gaggagctgc cgggtctcgg tgcgccggcc
    10921 gacgtcggcg ccgatctcgc gcagctcgcg gccgtccagg gtgatctcgc ggtcccggtc
    10981 gacgacgacc tcaggggcgg cgaggaagcc caggccgagg gagtcggcgc cgtggctgcc
    11041 gcgcacgtcc aggaaggacg acaggctgta cgtcccgggc tcgagccgga gcttcagggt
    11101 gccggagtcg ccgacgtggg ccgggaaggg gtcgacgccc tcggtgagcc gctggacggt
    11161 caggtcggcc ggggtcgcgg cgccggagcg gtccttgacg tgcaccgtga gcgtgtaccg
    11221 ctcgccctcc ttgaccagcc cgaacgcggt gtgcgcgagg ggcttcccgc tcgcgtcggc
    11281 cgccacgacc tggccgctcg tgtcgccgac cggcgccttg gacccgtccc cggtgaccgt
    11341 ggtcgaggcg gtgccgtgcg cgggcacggt gagggaggtg tcggcgagcg tggcgacgcc
    11401 ctcgggggcg ccccgcacgg acagcttcag ctcgacgtcc gtgtccgagg agttggtgta
    11461 ggcgacggtc ctggtgaccg gctcgtcggc ctcgtacggc caggagtaga agcccaggtc
    11521 ggcgctgccg gtcgcggtga cgtcggcgcc gacggccgcc ggcacgctga cccggcccgc
    11581 acccaactgg taggcggaga cgtccagttc cttggacgtg gacatcagcg cgtccttgag
    11641 ccgcgcgccg ctccagtcgg ggtgctcctc ggcgagcagg gcggccaccc ccgcgatgtg
    11701 cggcgtcgcc atcgacgtac cgtccatgga cgtgtagtcg ccgctgccct cggcgaggcg
    11761 ggagcgggcg gcgaggatgc cgacgcccgg ggccgacagg tcgggcttga gggcgttgtc
    11821 gccgtagcgg ggcccggcgc tggtgaacca ggcggcctgg tcggcggagt cgaccgcgcc
    11881 cacggtgagg gcggcgtcgg ccgcgccggg cgagcctatg gaggaggggg cgccggtgtt
    11941 cccggccgcg atcacgaaca gggcgccggt ctcgcgggac agggtgttga cggcctcggc
    12001 catcgggtcg gtgccgtcgc tgggttcggt ggagccgagg ctcatggaga cgatgtcggc
    12061 gtccacgtcc cgggcggccc actccatgcc cgcgatgatc tccgactcgc tgccgaagcc
    12121 ctcgtcgtcg aggaccttgc cgaccgcgag cgtggcgccg ggtgcgacac ccttctcctt
    12181 gccgtcggag gccgcgccgc tgccgcccac ggtggaggtg acgtgcgtgc cgtggccgtg
    12241 ccggtcggcg acctcctcgc cggggatgaa gctgcggctc tgcgcgatcc gccccgccag
    12301 gtcggggtgc ccggcgtcca cgccgctgtc cagcacggcc acggtgacgc ccttgccggt
    12361 cagccccgcc tcccaggcct cgggcgtgcc gatctgcgcg ttggactcgg ccatgtccgc
    12421 ggtgacccgc ccgtcgagcc acacgccctc gacaccggcg ccgcgacggg tgaattcgcg
    12481 ccagaatgca cgccccttgt cggcctcgac ggcggccccg cgcacgctgg gcagcgaccg
    12541 tgtccgctcg gccccccgcg gggtggcggc ccgcacgccc ttgccgtacg tcacgatcag
    12601 cggcagctcg cccgtctcgc tgtcggcgag cccctgctcc agcaacgcac cgacgtcgaa
    12661 gagccgttcg tcgaggctgc cgtcgcgcag gtacggcagg gcctcgtccg gtacgacggt
    12721 ggtccggccg ccaaaactgc tggtgcgcac ggccccggtg gcgccctcgg gccgctcgac
    12781 cgcgacggtc ttccggccgc cgccgaggtc ggtgacggtc acccggtcgc cggtgacgag
    12841 ggtgacggtg cgggccgcgt cggcggcggc cgtgcgggcg gccgccgttc gggatcgcgc
    12901 cgggtcgggg ggcgggtcct gcgccgccga ggtcccggcc ggcagcagcg cgatcacgag
    12961 ccccgccgac aggagggccg ccccgcgtct gactggtcct gtgctcatcc acgtctctct
    13021 tcgtgtcgtc gtagagtgcg gtgaagagtg ctgtgatcag tctcaggggg ccggtggggc
    13081 acgggagttg accggaggcg gcggttagtc gccctggcgg gtttccgcca gcggccgaac
    13141 ggaccggcgg cccgggacgg gacacggccg agtaccgtcc gtcacaatgg tgctgcgcac
    13201 ggacacgtac ggcacacggg gagcgagcgg cgtcatggac gggttggtcg agttcaggac
    13261 cgaggacggc gtgcgggtgg tcgtcgaggg cgtcgaggac gaggacggcg cgcggctggt
    13321 ctcgcgcggc gacggcccgg cccgcgcggc ccgcaccttc gaggactccc tggacggcgt
    13381 gcgggcggcg gccgcgtccg cgctgcgcgt cttccgggac ggctcgctcc gacccgacgc
    13441 cgtggagctg gagttcgggg tcaagctgag cgcggaggcc ggcgcggtca tcgcgaaggg
    13501 ctcggcggag ggccatctgg tggtgcggct gaactggtcg cccgagccgt cccccacgcg
    13561 taccgagccg cagccgtccg cgacgcgtcc cgaaccgcgg ccgtccccgg cgggtcccga
    13621 ggccccggac gccgtcgcgc tatcatgagc ggtgccgcgt ggcacgcccg cgtcgagtgc
    13681 ggcagggagg tcggcgccgg attcctcgtc tccgcccgcc ggttgctcac ctgcgcccat
    13741 gtcgtccggt gggccgaccg cgcgccggtg acggtgacct tcccgggccg ccgggagctg
    13801 ggcgagctgt ccggcacggt cgtcgtgcac ggcgggtggc aggagggcgc cgccgacctc
    13861 ggcgacctgg tggtactgga gctggaccgg gaggtgccgc tcgccccagc cgtcttcgcc
    13921 cggcccggaa cggagcggac cgtccccgtc cccgagctga tcgcctacgg cttccccaag
    13981 gggtacgacg agggcatgct cgcctcctac cgcgccctgc ccgggcccct catctccgac
    14041 gagtgggtcc agctggaggc cgtcacggcg cacgggcagc cgctggccgc cgggttcagc
    14101 ggcgcggcgc tgacactggc cgacggcacg gtcgtcggca tggtctccgc cgtggccggc
    14161 gcccgggacg tacgggtcgg caggatgctg cccgtcgagg tcatggcgcg ctactggccg
    14221 gagctgggcg agctggtgcc cacccccggc caccgggcgg acgcccgcag gcggctgtac
    14281 gcgctggtgc gccgggccga ggagagcggc ctggactgcg acccgaaccg gctgtacgtg
    14341 tccgccatgg acgcgttcga cccgccgctg ccggagggcg gtttcggctc cctgcgggag
    14401 gccgccgcct acgtgcagtg ggaggtgccg gacccggcgg cggtggcccg cttcgccgac
    14461 cggctgacgg agcggctgca cgccccgtcc ggtccggcgc cgcgccccgc ggcctggtcg
    14521 cccatcgtcg tggagatcga ccgcagcggt gccggtgccg accaggtcac cgtagaggtg
    14581 tccgcctacc gggacggccg gcgccgcccg gtgggttcgc gccggctggc ccgcggcgcg
    14641 gtgcggtcct tcgtccagga aggcatcgac gaggcgttca cccagctcga tcccggcgcc
    14701 gacgaactgc tcaccttcgt gctcccgcgc gagtggctga acgaaccggt ggcgcactgg
    14761 gagtgcggag aggacgactc cacgccgctg ggctgcgcct acccgctcgt ggtgaccgac
    14821 cggtaccgcc accgcagcgg acgcctccgc caccagctgc acaagaagtg gcgcaggctc
    14881 gggtccggca cgggcggcac gctgcaccgg gtggactgcg gcacccggga gcggccggcc
    14941 gggctgcgca agcggctgcg ggacgacgcg gagctggccg gtttcgccac cccgccctcg
    15001 gcggcgccgg agtacttcga ggtcggcctc aacctgcccg tccccgtgct gttgtggccg
    15061 ctgcgggagt gccccggcga ggagggaccc gacggccgct gctccggcac ggcgttcctc
    15121 gacgagctgg cggcgtcggt ggcggacgtg ccgccggccg aactgccgcg cctggtcatg
    15181 gaactgcgcg agacggcgga cgcggcggag gtcccggagg agcactgggc gcgggacgtc
    15241 cagctcctgt gggacgaccc ccgctgtttc gccgagccgc ccgccctgct ccactccccc
    15301 gtcggctgaa ccgcccgccg cgccatgcac cgacgcacca cggccgaccg cgaccgcgcc
    15361 gaaccgaccc gcgcaccgat ggccctaccg accgccgcac caacccctgc accgaccgcc
    15421 gcacctaccg cccggagaga agaacccatg cccttgtggc ccgtctacac cggcgcgcct
    15481 gacccccacg acggcatcgc ccggctgccc ccgcccccgc cctggcgggc cttcgacggc
    15541 ggccccgtgc tcgatccgcc ggacgcggac ggcgacaccg cggccgcctc gcccgaccgc
    15601 gcccaccgtg ccgcgaccta ccaggccacc gaggacacgg tgcagttggt caacgcggcc
    15661 ctgtacctgc gccgtccgct gctggtcacc ggtccgcccg gcaccgggaa gtcgtccctc
    15721 gcctacgcgg tcgcccgtga actgcggctc ggccccgtcc tcaggtggaa catcaccagc
    15781 cgcagcaccc tgggcgacgg cctctacacc tacgacccgc tctcccgcct ctacgcggcg
    15841 cgccacacca cgcagccgcc cgacgccccc gccgccaccg gcgtcgagga ccacctgcgg
    15901 ctgggcccgc tgggcaccgc cctgctgccg tacgcccggc cgcgcgccct gctcatcgac
    15961 gagatcgaca agagcgacct cgacctgccg aacgacctgc tgcacgtcct ggaggagggc
    16021 cagtacgaga tccccgaact cgtccgggcc tccagggaca tccccgacgg ccacgccgag
    16081 gtcctggccg acggcaccga ccagcgggtg ccggtggagc gcggccgggt ccgctgcaac
    16141 gcgttcccct tcgtcgtcct caccagcaac ggcgagcgcg agttcccgcc cgccttcctg
    16201 cgccgctgcg tctcgctgcg gctgcggcag cccgacgacg accacctcgc cgagatcgtc
    16261 cgcgcccacc tgggcgagcc cgacgggcac gcgcgccagt tgatccaccg gttcctgtcc
    16321 cgggtgggca gcggcgaact ggccacagac cagttgctca acgccatcta cctggcccgt
    16381 tcctccggtc tgggcgccga ctccctggac gagctggccg agcagctgat gccctacctc
    16441 ggccggtccg cgcagtccga cgccttctga tgcccaccga ccgccccggc acaccggacc
    16501 cgccgcccct gcccctcctc gccgatctcc tcggccgggc ggccaccggt gcccgcccga
    16561 cgccgctgga gctggccgaa ctcctgtggc tggccggtca catggagccc ccggagcagg
    16621 acccgcccga cggcccggcg tccggaacgc ggccggccga gccgccaccg gccccggagg
    16681 gcacccggga gcagggccag gaaggcgacg ggcaacggga gcgcgaccgg aagccggagc
    16741 gggaccggca cggcgaccgg gagcgtgacc gggacgggga ccgggaccgg gggccgggac
    16801 gagggccgtg gggcgacggg ccggggcggc ccagtacccg ctccgaggcc ccccgcaccc
    16861 ccttgcgcct gccgtccccc gcccccgcgc cgggcacctc ggcggcgcag ccgcacagcg
    16921 ccctgctcgc acccgcaccg ccgatgctgc gccacacgct ggcgttgcag cgtgccctgc
    16981 ggccgctgaa gcgccgtgcc gacgcgcccg tcggccacga ggtggacgag gccgcgaccg
    17041 ccgaccgcat cgcgcgcctc ggcgccggcc ccgagtggtg gctgcccgtg ctgcgccccg
    17101 tacgggaacg gtggctgcgc ctgcacctgg tgcacgacgc gggccccacg atgcccgtct
    17161 ggcggcccct cgtgcgcgaa ctgcaagccg ccctggccca gtcgggcgtc ttccgcaccg
    17221 tcaccctgca ccgcgcggac cccgacggca ccgtccgcgg cgacggcgcc cagatccccg
    17281 ccgacggccg tacggtgatg ctgctgatca gcgactgcat ggggccgcag tggcgggccg
    17341 gcccggacgg cgtccggtgg ttcgccacgc tgcgccgctg ggcacgccgc gcgcccctgg
    17401 cggtgctcca gccgctgccc gagcagttgt ggcgggacac cgccctgccg ccggtcccgg
    17461 gccggctgtc ggccccgcac cgggcggcgc ccagcgcctc gctcgccttc acgccgtacg
    17521 acaccgccgc gccccgcgcc cccgagggga ccgtgcacgt ccccgtgctg gagcccgggc
    17581 ccgagtggct ggcgaactgg gccgccctgg tcgcgagccc gggcggcacc ccgtacccgg
    17641 gcgcggccgc ggcgctgcac cgaccgctgc cggccgacgc cgacgaccgc accgacgtcg
    17701 cgcggctgtc gcccgaggaa ctcgtcctgc gcttccgcgc cagcgcctcc ccgcaggcct
    17761 accggctggc cggccatctc gcgctggggc gccccgacct gcccgtgatg cggctggtgc
    17821 aggccgcggt cgagccggac ccgcggcccc agcacctggc cgaggtgatc ctcggcggac
    17881 tgctgaccac ggtcgccggg ccgcccggct cctacgcctt ccgccccgga gtgcgcgagc
    17941 tgctcctgcg cgggctgccc cgcaccgccc gcaaccgcac ccacgacctg ctgctgcgca
    18001 ccggcggcct gatcgacgac cgggcgggcc gttcgccggg cgagttccgc gcgctgatcc
    18061 cctcccggaa gggcaccgag cgggccggcc cgagcgagtc gttcgcgacg atcagcgagg
    18121 agagcgtccg gcagctgacc gtgcgggagc ggccctccgc cccctcgccc ttcccgcccg
    18181 gcctgggcgc ccgctaccgg cccacgcgac ggctcacgcc gtccggcagg atctggctgg
    18241 cggaggacac cggaccggac cggacggcac cggaccggac cccggcggac cggacggcgg
    18301 cccaccccgt gccgacgaac cggacggtgg cgatccggct gcacgacccg gccaccggcc
    18361 cggccgcgcg ccagacgttc ctgcgcaacg cgcgccggct gacgcggctc tcccacccga
    18421 acctggtgac cgtgctcgac gcgggcatcg agggcgacgt cccgtacgtc gtcatggagc
    18481 acctcgacgg catagcgctg ggcgccctca cccggtccgg ggacgggcgg ctgccggtgc
    18541 cgctgacggt gtccgtgggg gcgcagctgg cccgggcgct caccgccctg caccgggcgg
    18601 gtctggcgca cggcgggctg gaggcgtccc gggtggtcct cctgccggac ggcacggtcc
    18661 ggctcagcct cttcgaaccg gctctggcct tggggccggg ggcgcgctcg gcggacctgc
    18721 gtgccctgtg cgaggtgctg ctgcggctga cgtcggggac ctcgcgcccg gccgtcccgg
    18781 tcgactcccg ccgcctgcac cggctgccca ccgccctgcg gatccactac gcgcacgcct
    18841 tcgaccagct gctgtctccc tcgccggcgg cccaggcccg gggcctcgac ctgctcgggg
    18901 acccggcgct gctcgcccgc gcgggcgagg cgtacgcgcc gcgccggtac cgggccctgg
    18961 gcccgctgcg ggtcggcctc ccggacggtc cggccgacct gccgagggac gtgcgcgcgc
    19021 tgctcgcgat gctgctcctc aagcacggcc gcacggtgac ccacgaggag ctgcggtggg
    19081 gcctgtggga cccgggcaac gagccgcgca acccgcggag cgagacgacc cggctggcga
    19141 agcggctcgc ggagatcctt ggcccgggcg tcctggccac ggccgcccac ggctacgccc
    19201 tgcacaccag cgccgacgag ctggatttgg tgcgctgcga cgagctggtg cggcgcgccg
    19261 acgcggcccg gctggagggc gcgctcgccg aggcgcacga cctggtctcc ggggcgctgt
    19321 cgctgtgggg cgacgccgag cccctggcgg gcgtgcccgg ccccgccgcc cgcaccgccc
    19381 ggacccgcct gctgcggctg cggctcgccc tgcacaccaa gcgcgccgag ctggacctgg
    19441 tcctcggcga gtacgaccgg gccgccgccg aactgtccgg cctgctgcgc gcccacccgc
    19501 accgggagga cttccgccgc ctctgcctga tcgccctgcg ccgccagggc cgggtcgagg
    19561 aggcgctgga ggtgtacgag gagtacgagc tgtccggcgg acggagcccg gccctgacgg
    19621 cgctgggccg ggagctgcgc gaggagtacg ccgaaccggt ggacgacgcg cccccgtgga
    19681 ccgagtacga gcagcgcccc gtggagccgg gcgcccccga gtcgacggtg tccgcgccgg
    19741 acgagttgcc ggagggcccc ttccccacgg aggacggcct ctggacgccc ctgctggacg
    19801 acgacgccga gcacgacacg gcacaggccc gggcggaagc ggacgagagg gaggaacggg
    19861 cggagagccg ggcagcgctg cgggaagcga tgcgcgccga gggcctggaa ccggagccgg
    19921 aactggacga ggatcctggg ccggaggaag aggaggagcc ggacgagccg ccctggatcg
    19981 acttcgacac cggtttccgc gcctgcgccc gctacaccct cgccgacggc ccggtggacc
    20041 gcgacgcccg cgcggcactg cacggcctgg tcacggagct gctggcggac agcggggcgg
    20101 acgccgccgc ctacgaactg gtggacgagc ccggtggccc gctcgtgctg ctggcgccgc
    20161 gggccgaggc cgccccgctc ctgagggcga ccgtcgaagg tctgcccggg cggctggccc
    20221 gcctggccgg cctgcggttg cggatcgagt tctggcaggt ggagttcggg ctggacggga
    20281 acggggagca gtcactgggc cgtgccgacg ccgacgcggt cggcgcggtc ctggacgcct
    20341 ccgccgcgca ggccgtcgtc gtgctctccg actccctgta ctacgacgag gtgcgcgagg
    20401 aggggcagta cgggcccgcc ttcccgccgg acctcttccg cccgctggcc gacgacaccg
    20461 gctggtacca cctggtcgag ggcggcgggc gccccggtcc ggcggcggac ctccgctgac
    20521 ccggccgggc gcggtcctcc cggccggcgc cgggaactcc cctcgttcag cggccccccg
    20581 cccggccccc tccagcgggc gcccgcccgc gcggccgcgc acgatcagtg cctaagaggc
    20641 cgcccaccgg gcggccccgc acggtccgcg ctctcgggag gattcgccat gaccgccagt
    20701 actgccaata ccgccagtct ggaggcgctg cgccgctgcc acttcgccgt cgacctgggc
    20761 gcggcgcgga cccgcgtgta cgtcaagggt gccgggctcg tcgtcgacca gccgtccgcc
    20821 gcggcggtca acacccgcac gggcgcgctc atcgcggtcg gcgacttcgc ggagaagatg
    20881 accggccgca cccccggcta catccgtgtc gtgcggcccg tctccggcgg cacggtggtc
    20941 gacatcgaga tggcccagcg catgctgcgt catctgctcg gcgaccgggt ccgccgcgcc
    21001 ctgcgccgca agccgcggct gcgggccgcc gtctgcaccc cgcacgacgc ggatccgctg
    21061 tcccagcgcg cggcgatcga gacactggtc gggctcggcg cgcgccgcgt ggaactcgtc
    21121 gacacgctca tcgctgcggc ggtcggctgc ggactgcccg tggagcagcc cgaggcaacg
    21181 atgatcatgg tgtgcggcgc gcacgccacg caggtcgcgg tgctctccct gggctcgatc
    21241 gtgaccgcgg tgcgcgttcc ggtgggcggc gaggccgtgg accacgcgat cgtgcagctg
    21301 ctgcgccacc agcacgagct ggtgctgccc agccagtccg tgcgcccgtt gcagctcgcc
    21361 ctgtccggca acgggctgac cccgcaggga ccgtcgtcca ccgagatcca cggccgggac
    21421 gtggcgaccg ggctggcccg cagtgtgcgg gtcgacaccg ccacggtgcg caacgccatc
    21481 cagaccccgc tgacggccgt gctcgacggc atcggcaagg tgctgcggga ctgcccgccc
    21541 gacctggtcg cggacctcgc cgaccgcggg atcatgatgg tcggcgggag cgcgctgctg
    21601 ccgggcttcg accagatgct gcgtcaggcc accggtatgc cggtgcacat cgcggagcgg
    21661 cccgacgtgt gcgcggtcca gggcctcggc agcatgctgg agggccgggt ggagccgctg
    21721 gtcctgcacc cgacgaccgc cggctccgac tcgcacgccg actccgactg a
//
