LOCUS       BGC0000597             10846 bp    DNA     linear   CON 22-DEC-2022
DEFINITION  Streptomyces sp. e14 supercont1.1, whole genome shotgun sequence.
ACCESSION   BGC0000597
VERSION     BGC0000597
KEYWORDS    .
SOURCE      Streptomyces sp. e14
  ORGANISM  Streptomyces sp. e14
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            GG753626.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated scaffolds were added in April 2010.
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 13:54:04
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 1489806
            Orig. end    :: 1500652
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1344
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1246:monooxygenase FAD-binding (Score: 422.5; E-value:
                     3.2e-128)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SSTG_01176"
                     /transl_table=1
                     /translation="MAGLLAAAALSRAVDEVVVLDRDDLPDGPEHRKGLPQGRHAHLLM
                     AGGLAAMEEVLPGADLRGRLLAAGAREISLGSGMLGLSPEGWFRRWRHDGPSMLSCTRA
                     LLDWTVREAFVAHTGVRIRKARAVGLVGDADRVRGVRVAEPDGTETELAAALVVDASGR
                     GSRIDVWLAELGITGIRTRTVDSGLVNATRVYRTPAGAEQFPLTVVQADPYASAPGRSG
                     MVMPVEGDRWMVSLAGTRGGEPPADPDGFLAYALALPDPIVGRLVSGAEPLTEVHISRS
                     TSNVRRHLEKAGRWPEGFVALGDAVATFNPAYGQGMSVAALGARLLGEEAGRAGVDAPG
                     FARRVQRGAARSVDAAWAAAVGQDVWYPDSRGARPTAADRLVTAYSRRLTRAATGSYRA
                     AAVLWDVTSLLAGPEHLFRPATLLDVACGTQLLPPLSGPPLTRPSGRS"
     subregion       1..10846
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="ribosomal"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..10846
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1433..2296)
                     /locus_tag="SSTG_RS06145"
                     /old_locus_tag="SSTG_01177"
     CDS             complement(1433..2296)
                     /EC_number="3.1.1.99"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009188435.1"
                     /locus_tag="SSTG_RS06145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSTG_01177"
                     /product="SMP-30/gluconolactonase/LRE family protein"
                     /protein_id="WP_009188435.1"
                     /transl_table=11
                     /translation="MTPQTPAPEYEVALDARAELGEGPTWDPAAGRLIWLDILACRVHT
                     YDPVTGRRTVRTTEQHVGAAKPRAGGGLVLNLRDGVGLLDPDGAFRWLHREPVPGRRGN
                     DAAVAPDGSLWAGTMRYDEAEGGGTLSRLTGDGSAQTVLSDVTVSNGTGWSPDGRLMYY
                     VDTPTRRIDVFDHDGGRVANRRQLALVEEGAGFPDGLAVDAEGCVWVALWDGGAVRRYT
                     PTGELDRIVRLPVPRPTACAFGGPALTDLYITTARVGLTAPHPLAGALLVVPDAGKGLP
                     QPPFAG"
     gene            complement(2293..3066)
                     /locus_tag="SSTG_RS06150"
                     /old_locus_tag="SSTG_01178"
     CDS             complement(2293..3066)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195:IclR family
                     transcriptional regulator (Score: 257.3; E-value: 2e-78)"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019982229.1"
                     /locus_tag="SSTG_RS06150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSTG_01178"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_009188436.1"
                     /transl_table=11
                     /translation="MGRLVPAVTRALDILELFLDGDGTLSAPDIVRRLRLPRTTVHELV
                     TTLAARKYIVQVTGQPGRYRLGVRPYQLGSRYAEHLDLAAEGQQVARTVAETCDETVHV
                     AILEDTDVIYIAKVDSTHAVRMVSAAGRRLPAHCTSVGKMLLASLPERELAARIPDDAE
                     LPAMTPDSITDPAALRTALAEIRQRGLAVENRESNPDVSCVAAPVRDRTGQVVAALSIS
                     VPMIRWSEERRAELEQLAVKGAADLSERLGHRSAV"
     gene            3253..3837
                     /locus_tag="SSTG_RS06155"
                     /old_locus_tag="SSTG_01179"
     CDS             3253..3837
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019982230.1"
                     /locus_tag="SSTG_RS06155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSTG_01179"
                     /product="hypothetical protein"
                     /protein_id="WP_043261715.1"
                     /transl_table=11
                     /translation="MPASFTPFTPLDFQLVLLRRMADHNPELVADARRELGVSLTDMRE
                     ANKRWQAMVRSPRSRSAASRYRSVLGPPESAAARRIGDLDCEARQWPLPLWPELRFEVL
                     VGPNGQVWNEWLVRAPGAEPPVLRTLDDLAPWSCTVDEAARAFAPARPLEGTAPTRWGL
                     AFTAPDGGGVRREVVAEFTWGLLQRTRTADE"
     gene            3977..5454
                     /locus_tag="SSTG_RS06160"
                     /old_locus_tag="SSTG_01180"
                     /pseudo=""
     CDS             3977..5454
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004988486.1"
                     /locus_tag="SSTG_RS06160"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="SSTG_01180"
                     /product="acyl-CoA synthetase"
                     /pseudo=""
                     /sec_met_domain="AMP-binding (E-value: 1.7e-09, bitscore:
                     26.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSLFPALTDAPGARPALRFGPRSLTYAQLAGAAGAVGARVRGEG
                     RVAVWATPELETAVAVVGVLLAGAAAVPLNPKSGEKGWRTSSATARPPWCWPRPVTNCR
                     PRWPA"
     CDS             4123..5454
                     /NRPS_PKS="Domain: AMP-binding (26-348). E-value: 1.3e-66.
                     Score: 216.7. Matches aSDomain:
                     nrpspksdomains_SSTG_01180_AMP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     293.7; E-value: 3.5e-89)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SSTG_01180"
                     /sec_met_domain="AMP-binding (E-value: 2.3e-77, bitscore:
                     249.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MGDAGAGDGGRGSGRAAGRGRRRAAQPEVRGEGLAHILGDSAPSV
                     VLAAPGDELPPALAGLTRIDVDVEAREEAPVADAGDGDPALIVYTSGTTGPPKGAVLPR
                     LALATTLDALADAWRWTGEDVLTHGLPLFHVHGLVLGVLGPLRRGGSVRHLGRFSTGGV
                     AAELSGGATMLFGVPTMYHRIAEALPGDPELAKALAGARLLVSGSAALPVHDHERIAAA
                     TGRRVIERYGMTETLMLCSSRWTPPDPRPSVRADGEARAGTVGVPLPGVELRLVEEDGT
                     PITAYDGETVGEIQVRGPNLFTEYLNRPDATAAAFTADGFFRTGDMAVREADGYVRIVG
                     RKATDLIKSGGYKIGAGEIENALLEHPGVREAAVTGEPDADLGERIVAWIVPADPPSPP
                     GERELADHVARRLAPHKRPRVVRFLDALPRNDMGKIMKRALPQG"
     aSDomain        4201..5166
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SSTG_01180_AMP-binding.1"
                     /evalue="1.30E-66"
                     /label="SSTG_01180_AMP-binding.1"
                     /locus_tag="SSTG_01180"
                     /protein_end="348"
                     /protein_start="26"
                     /score="216.7"
                     /tool="antismash"
                     /translation="PEVRGEGLAHILGDSAPSVVLAAPGDELPPALAGLTRIDVDVEAR
                     EEAPVADAGDGDPALIVYTSGTTGPPKGAVLPRLALATTLDALADAWRWTGEDVLTHGL
                     PLFHVHGLVLGVLGPLRRGGSVRHLGRFSTGGVAAELSGGATMLFGVPTMYHRIAEALP
                     GDPELAKALAGARLLVSGSAALPVHDHERIAAATGRRVIERYGMTETLMLCSSRWTPPD
                     PRPSVRADGEARAGTVGVPLPGVELRLVEEDGTPITAYDGETVGEIQVRGPNLFTEYLN
                     RPDATAAAFTADGFFRTGDMAVREADGYVRIVGRKATDLIK"
     CDS_motif       4375..4428
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SSTG_01180_0001"
                     /evalue="2.20E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="SSTG_01180"
                     /protein_end="102"
                     /protein_start="84"
                     /score="20.2"
                     /tool="antismash"
                     /translation="ALIVYTSGTTGPPKGAVL"
     CDS_motif       4990..5070
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SSTG_01180_0002"
                     /evalue="6.40E-09"
                     /label="NRPS-A_a6"
                     /locus_tag="SSTG_01180"
                     /protein_end="316"
                     /protein_start="289"
                     /score="28.1"
                     /tool="antismash"
                     /translation="TVGEIQVRGPNLFTEYLNRPDATAAAF"
     CDS             complement(5777..9436)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 269.2; E-value: 1.4e-81)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SSTG_01181"
                     /sec_met_domain="Peptidase_S8 (E-value: 5.9e-59, bitscore:
                     189.1, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MIALLPAGQAAARQTAGAAPTAKPPTTVPETGSAVALGTTSTAAP
                     AATPRTVTLVTGDKVTVTDLAGGKKTVTVQRPAGATGAVRTQVADGAISVVPDEALPYL
                     RAGRLDRRLFDVSALLRQGLADSRTGELPLIVTYGKGARTATPPGTERTRALASVHGAA
                     VAAAKGRVFWRDFTRRGTARGLAADGVDKVWLDGRVTADLAESNAQIGTAKAWQAGLTG
                     KGVTVAVLDTGVDATHPDLAGRIKQSKSFVEGEEVADRNGHGTHTASTVGGSGAASDGA
                     EKGVAPDADLVVGKVLDDQGTGSESQIIAGMEWAARDAHARIVSMSLGSEEPSDGADPM
                     AQAVDTLSAETGALFVVAAGNTGAPSSIGSPGAADAALTVGAVDFADQAAYFTSAGPRS
                     GDNALKPDLAAPGVDILAARSQLTEGSGYYTTMSGTSMATPHVAGAAALLAQEHPDWSG
                     ARLKDALMSTSKQLDASAYTLGAGRVSVPDAVTATVTATGSADLGFHAWPYSSDRPVTR
                     TLTYTNTSDQPVELTLVVQGAPQGVATLADTALAVPAHGTATTTVTGDAGEAPVGETSG
                     QIVASAAGTPVAHTVFALVKEEERYTLTVHVKDRSGAGTAADLAVQRLAEGVDPVPARV
                     GDSGTLRLRLQPGTYSLTSFLDVHGGHGRDSLGLGFLAAPEITLDRDREVTLDGRKLRE
                     IRADVGRRTETRQLLMEYDRSGGGSDLFGAVQVPSTYDSVFAAPTGRVTRGGFEYRTVW
                     RLGQPLLDVKGIGEAVAQSGGTLTDGRSRLPLVDVGDGDFTGKNVRGKAVLARLADGAE
                     PTALAQAAQDAGVKALFVTDDTPGRLSAWWGADDDSDRPFPIASVNAADAARLRAAGRV
                     DMTATRNTPYVYDLSEGHAGQIPDRDLTFRPGERQLARIGVEFHAARPASGGEFRYSIT
                     DAFPVGIGFQERIDYPARRTDYVSTGPGQRWHESVSVGDGTLEERSGLVRYTGGSHPAL
                     DWFKPVWHPWLGTGLGWGQQRAGDTLRFNAPGWGDSGPDHTGFGDVYSADSGMSQTTEV
                     FVDGESADRNPDSTAYVWDAPADAHTYKLVTDTALDAARWPLATRGHAEWTFRSAATPD
                     DHWTALPLINLALDLDTDLAGALRAGSRVPVGLRAAYAAGAPGAGTIRDGRLEVSYDAG
                     ATWRTVRLTGGHAEWRGTLTVPRGAASVSLRASAGDDKGGSVRQEIVRAAGVK"
     gene            complement(5777..9490)
                     /locus_tag="SSTG_RS06165"
                     /old_locus_tag="SSTG_01181"
     CDS             complement(5777..9490)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 269.4; E-value: 1.2e-81)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011028358.1"
                     /locus_tag="SSTG_RS06165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSTG_01181"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_043260784.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 6e-59, bitscore:
                     189.1, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRGPDGRRATLLLSAGLVIALLPAGQAAARQTAGAAPTAKPPTT
                     VPETGSAVALGTTSTAAPAATPRTVTLVTGDKVTVTDLAGGKKTVTVQRPAGATGAVRT
                     QVADGAISVVPDEALPYLRAGRLDRRLFDVSALLRQGLADSRTGELPLIVTYGKGARTA
                     TPPGTERTRALASVHGAAVAAAKGRVFWRDFTRRGTARGLAADGVDKVWLDGRVTADLA
                     ESNAQIGTAKAWQAGLTGKGVTVAVLDTGVDATHPDLAGRIKQSKSFVEGEEVADRNGH
                     GTHTASTVGGSGAASDGAEKGVAPDADLVVGKVLDDQGTGSESQIIAGMEWAARDAHAR
                     IVSMSLGSEEPSDGADPMAQAVDTLSAETGALFVVAAGNTGAPSSIGSPGAADAALTVG
                     AVDFADQAAYFTSAGPRSGDNALKPDLAAPGVDILAARSQLTEGSGYYTTMSGTSMATP
                     HVAGAAALLAQEHPDWSGARLKDALMSTSKQLDASAYTLGAGRVSVPDAVTATVTATGS
                     ADLGFHAWPYSSDRPVTRTLTYTNTSDQPVELTLVVQGAPQGVATLADTALAVPAHGTA
                     TTTVTGDAGEAPVGETSGQIVASAAGTPVAHTVFALVKEEERYTLTVHVKDRSGAGTAA
                     DLAVQRLAEGVDPVPARVGDSGTLRLRLQPGTYSLTSFLDVHGGHGRDSLGLGFLAAPE
                     ITLDRDREVTLDGRKLREIRADVGRRTETRQLLMEYDRSGGGSDLFGAVQVPSTYDSVF
                     AAPTGRVTRGGFEYRTVWRLGQPLLDVKGIGEAVAQSGGTLTDGRSRLPLVDVGDGDFT
                     GKNVRGKAVLARLADGAEPTALAQAAQDAGVKALFVTDDTPGRLSAWWGADDDSDRPFP
                     IASVNAADAARLRAAGRVDMTATRNTPYVYDLSEGHAGQIPDRDLTFRPGERQLARIGV
                     EFHAARPASGGEFRYSITDAFPVGIGFQERIDYPARRTDYVSTGPGQRWHESVSVGDGT
                     LEERSGLVRYTGGSHPALDWFKPVWHPWLGTGLGWGQQRAGDTLRFNAPGWGDSGPDHT
                     GFGDVYSADSGMSQTTEVFVDGESADRNPDSTAYVWDAPADAHTYKLVTDTALDAARWP
                     LATRGHAEWTFRSAATPDDHWTALPLINLALDLDTDLAGALRAGSRVPVGLRAAYAAGA
                     PGAGTIRDGRLEVSYDAGATWRTVRLTGGHAEWRGTLTVPRGAASVSLRASAGDDKGGS
                     VRQEIVRAAGVK"
     gene            9806..10846
                     /locus_tag="SSTG_RS06170"
                     /old_locus_tag="SSTG_01182"
     CDS             9806..10846
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009188440.1"
                     /locus_tag="SSTG_RS06170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SSTG_01182"
                     /product="rod shape-determining protein"
                     /protein_id="WP_009188440.1"
                     /transl_table=11
                     /translation="MTASLEQLRRCHFAVDLGAARTRVYVKGVGLVVDQPSVAAVNTRT
                     GALIAVGEFAERMTGRTPDYIRVVRPVSGGTVIDIEMAQRMLRHLLGDRMRRSLRRKAR
                     LRAAACTPHDADPLAQRATIETLVGLGARRVELVDTLIAAAVGCGLPVERAEATMIMVC
                     GAAATQVAVLSLGSIVTAERVPVGGEAVDNAIVQYLRHEHALMLPSQSVRPLQLALHGT
                     GLTPQGPATTEIHGRDVATGLARSVLVDTAAVREAIQTPLTAVLDGIGKVLRECPPDLV
                     ADLVESGLTMVGGSALLPGLDQMVRKATGMPVHIAERPDVCAVQGLGEMLEGRIEPLVL
                     DPLGAY"
ORIGIN
        1 ctggccggtc tgctggccgc ggcggcgctg tcccgcgccg tggacgaggt ggtcgtgctc
       61 gaccgcgacg acctgcccga cgggcccgag caccgcaagg gcctgccgca gggccggcac
      121 gcgcatctgc tgatggccgg cgggctggcc gccatggagg aggtgctgcc cggcgcggat
      181 ctgcgcgggc ggctgctggc ggccggggcg cgggagatat ccctcggctc gggcatgctg
      241 ggcctgtcgc ccgagggctg gttccggcgc tggcggcacg acggcccgag catgctcagc
      301 tgcacccgcg cgctgctgga ctggacggtg cgggaggcct tcgtcgcgca caccggcgtg
      361 cggatccgca aggcgcgggc cgtgggtctg gtgggcgacg cggaccgggt gcggggcgtg
      421 cgggtggcgg agccggacgg tacggagacg gagctggccg ccgccctcgt ggtcgacgcg
      481 agcgggcgcg ggtcgcggat cgacgtgtgg ctggcggagc tggggatcac cgggatccgg
      541 acgcggaccg tcgactcggg cctggtcaac gccacccgcg tctaccgcac cccggccggc
      601 gccgagcagt tcccgctcac cgtggtgcag gccgacccgt acgcgtccgc gcccggccgc
      661 agcgggatgg tgatgcccgt cgagggcgac cggtggatgg tgagcctggc cggcacccgg
      721 ggcggcgagc cgccggccga cccggacggc ttcctcgcgt acgcgctggc cctgccggac
      781 ccgatcgtcg gccggctcgt ctcgggcgcc gagcccctca ccgaggtgca catcagccgc
      841 agcaccagca atgtgcggcg ccatctggag aaggccgggc gctggccgga gggcttcgtc
      901 gcgctcggcg acgcggtggc caccttcaac ccggcctatg ggcagggcat gtcggtggcg
      961 gcgctgggcg cgcggctgct cggcgaggag gcggggcggg ccggggtgga cgcgccgggg
     1021 ttcgcgcggc gggtgcagcg cggggccgcc cggtcggtgg acgcggcgtg ggcggcggcc
     1081 gtcgggcagg acgtgtggta cccggactcg cgcggggcgc ggccgaccgc ggcggaccgg
     1141 ctggtcaccg cctacagccg ccgcctgacc cgggccgcca ccggttccta ccgcgcggcg
     1201 gcggtcctgt gggacgtgac gagcctgctc gccggccccg agcacctctt ccgcccggcc
     1261 accctcctgg acgtggcctg cggcacacaa ctgctgcccc cgctgtccgg gccgccgctg
     1321 acgcggccga gcggaagatc ctgaagagct gaccggacgg gaaggtgagc gggccccggc
     1381 cgggcagggg cgcgaagacc ccgtcccgcg cgtcccgccc cgccggtcgc cttcagcccg
     1441 cgaacggcgg ctggggcagg cccttgcccg cgtccgggac gaccaggagc gccccggcca
     1501 gcgggtgcgg ggcggtcagg ccgacgcggg ccgtggtgat gtagaggtcg gtgagggcgg
     1561 ggccgccgaa ggcgcaggcg gtggggcgcg gcacggggag ccggacgatc cggtccagct
     1621 cgcccgtcgg ggtgtagcgg cggaccgccc cgccgtccca cagggcgacc cacacgcagc
     1681 cctcggcgtc cacggcgagt ccgtcgggga acccggcgcc ctcctccacc agcgccaact
     1741 gccgccggtt cgcgacccgt ccgccgtcgt ggtcgaagac gtcgatacgc cgggtcgggg
     1801 tgtcgacgta gtacatgagg cggccgtccg ggctccagcc cgtgccgttg ctcaccgtca
     1861 cgtcggacag caccgtctgc gccgagccgt cgccggtgag gcgggagagc gtgccgccgc
     1921 cctcggcctc gtcgtagcgc atggtcccgg cccacaggga gccgtcgggg gccacggcgg
     1981 cgtcgttgcc ccggcggccg ggcaccggct cgcggtgcag ccagcggaaa gcgccgtcgg
     2041 ggtcgagcag gccgacgccg tcgcgcaggt tcagcaccag tccgccgccc gcgcgcggtt
     2101 tggccgcgcc cacgtgctgt tcggtggtgc gcaccgtgcg gcggccggtg accgggtcgt
     2161 aggtgtgcac ccggcaggcg aggatgtcga gccagatcag ccggccggcc gccgggtccc
     2221 aggtgggtcc ctcgcccagc tcggcgcggg cgtccagcgc gacctcgtac tcgggcgcgg
     2281 gggtctgcgg tgtcatacgg cactccggtg gccgaggcgt tcggacaggt cggcggcgcc
     2341 cttgacggcg agctgctcca gctcggcgcg gcgctcctcg ctccagcgga tcatgggcac
     2401 ggagatggac agggcggcga ccacctgtcc ggtgcggtcg cgcaccgggg cggccacgca
     2461 gctcacgtcc gggttggact cgcggttctc cacggccagg ccgcgctgcc ggatctcggc
     2521 gagcgcggtg cgcagggcgg cggggtcggt gatgctgtcg ggggtcatcg cgggcagttc
     2581 ggcgtcgtcg gggatgcgcg cggcgagttc ccgctcgggc agggaggcca gcagcatctt
     2641 gcccacggag gtgcagtgcg cgggcagccg gcggccggcc gcggagacca tgcgcaccgc
     2701 gtgggtggag tccaccttgg cgatgtagat gacgtcggtg tcctccagga tcgcgacgtg
     2761 cacggtctcg tcgcaggtct cggcgacggt gcgggcgacc tgctggccct cggcggcgag
     2821 gtcgaggtgt tcggcgtagc ggctgccgag ctggtagggg cggacgccga gccggtagcg
     2881 tccgggctgg ccggtcacct ggacgatgta cttgcgggcg gcgagcgtgg tgaccagctc
     2941 gtggaccgtg gtgcgcggca gtcgcagccg gcgcacgatg tcgggggcgg acagcgtgcc
     3001 gtccccgtcg aggaagagct ccagtatgtc gagagcccgg gtcacggcgg gtacgaggcg
     3061 tcccacgacc ggcccccctc cgctgttcca ggcctgtgtt cgagatatca acaggcgatc
     3121 ggcatgacga acacaggcta gtcatgggcg ggggcgggcg gcaatgggtc gtacgggtca
     3181 cgcggtgcgg gggtgcacgc cgccttcggc tacgggccgc cggtccggcc gggcatgggc
     3241 gacgatgggc tcatgcccgc gtccttcacc ccgttcacgc cgctcgactt ccagctggtg
     3301 ctgctgcgcc ggatggccga ccacaatccg gagctggtgg cggacgcccg ccgggaactg
     3361 ggcgtctcgc tcacggacat gcgggaggcg aacaagcgct ggcaggcgat ggtccgctcc
     3421 ccgaggtcgc gctcggccgc ctcccgctac cgctcggtcc tcggcccgcc cgagtcggcc
     3481 gcggcgcgcc gtatcggcga tctggactgc gaggcccggc agtggccgct gccgctctgg
     3541 ccggagctgc gcttcgaggt gctggtcggc ccgaacgggc aggtctggaa cgagtggctg
     3601 gtccgcgcgc ccggcgccga gccgcccgtc ctgcgcaccc tggacgacct ggccccctgg
     3661 tcctgcacgg tggacgaggc ggcgcgcgcc ttcgccccgg cccgccccct ggagggcacc
     3721 gcgcccaccc gctgggggct ggccttcacg gcccccgacg gcgggggcgt acggcgcgag
     3781 gtcgtcgcgg agttcacctg ggggctgctc cagcggacgc ggacggcgga cgagtagcgg
     3841 gcggggagga cccgtacgcg cgacccgcgg ggaaagtgac cggtgcgacg ctccccgcgg
     3901 cggcggaggg cgtcgctcgt ggggtaggaa cgggggtgtc gtccccgagt caccccgagc
     3961 caccaggagt cgccgcgtgt cctccctctt tccggccctc acggacgcgc cgggcgcgcg
     4021 tcccgcgctg cgtttcggcc cccgctcgtt gacgtacgca cagctcgccg gggcggccgg
     4081 ggccgtgggc gcgcgggtgc gcggggaagg ccgggtcgcc gtgtgggcga cgccggagct
     4141 ggagacggcg gtcgcggtag tgggcgtgct gctggccggg gccgccgccg tgccgctcaa
     4201 cccgaagtcc ggggagaagg gctggcgcac atcctcggcg acagcgcgcc ctccgtggtg
     4261 ctggccgcgc ccggtgacga actgccgccc gcgctggccg gcttgacgcg gatcgacgtg
     4321 gacgtcgagg cgcgcgagga agcccccgtc gccgacgccg gggacggcga cccggccctg
     4381 atcgtgtaca cctccggcac caccggcccg cccaagggcg ccgtgctgcc gcgcctcgcc
     4441 ctggccacca ccctggacgc gctcgccgac gcctggcggt ggaccggcga ggacgtgctg
     4501 acgcacgggc tgccgctgtt ccatgtgcac gggctggtcc tcggcgtcct cgggccgctg
     4561 cggcgcggcg gttcggtgcg gcatctgggc cggttcagca ccgggggcgt ggcggcggag
     4621 ctgagcggcg gcgcgacgat gctgttcggc gtgccgacga tgtaccaccg gatcgcggag
     4681 gcgctgcccg gcgacccgga gctggccaag gcgctggcgg gggcccggct gctggtctcc
     4741 gggtcggcgg cgctgcccgt gcacgaccac gagcggatcg cggccgccac cggccggcgt
     4801 gtgatcgagc ggtacggcat gacggagaca ctgatgctgt gctcgtcccg gtggacaccc
     4861 ccggaccccc ggccgagcgt gcgcgccgac ggcgaggcgc gggcggggac ggtcggggtg
     4921 ccgctgccgg gtgtggagct gcggctggtg gaggaggacg gcacgccgat cacggcctac
     4981 gacggggaga cggtcggcga gatccaggtg cgcgggccga acctgttcac cgagtacctc
     5041 aaccgccccg acgcgacggc cgccgccttc accgccgacg gtttcttccg caccggggac
     5101 atggcggtgc gcgaggccga cgggtatgtg cgcatcgtcg gccgcaaggc caccgatctg
     5161 atcaagagcg gcggttacaa gatcggcgcc ggcgagatcg agaacgcact gctcgaacat
     5221 ccgggggtgc gggaggccgc cgtcaccggg gaaccggacg ccgacctcgg ggagcggatc
     5281 gtcgcctgga tcgtcccggc cgacccgccc tcgccgcccg gggaaaggga gttggccgac
     5341 catgtggccc ggcggctggc cccgcacaag cgcccccgcg tcgtccggtt cctcgacgcg
     5401 ctgccccgga acgacatggg gaagatcatg aagcgggcgc tgccgcaggg gtgagggggc
     5461 cgggcttcca tcgcggtgat ccgaacacgg gatcaggtgt tcgctggaac aggtgatcgt
     5521 cgctcatacg accacctgaa cagttggtgc cgacacatac ttacggtgcg caagagaccg
     5581 gctgcagacg gtagttgcgc gtatgtccca catgttcacc gcaaggagaa gcacgatcat
     5641 gaacctcatc accgacgtcc tcgccggcct cgtccacttc atcggctggc tggtctgacg
     5701 tccacccaca cccacggcgg cgccgcctcc ccgtcccagg gaggcggcgc cgcccgcgtg
     5761 ttcccgctcc cccgggctac ttcacgcccg cggcccggac gatctcctgc cgtaccgagc
     5821 cgcccttgtc gtcgcccgcg ctcgcccgca gcgagacgga ggcggcgccg cggggcacgg
     5881 tgagcgtgcc gcgccactcg gcgtgcccgc cggtgagccg taccgtccgc caggtcgccc
     5941 cggcgtcgta ggacacctcc aggcgcccgt cccggatcgt cccggcgccc ggcgcgcccg
     6001 ccgcatacgc ggcgcgcagc ccgaccggca cccggcttcc ggccctgagg gcgcccgcga
     6061 ggtcggtgtc gaggtcgagg gcgaggttga tcaggggcag cgcggtccag tggtcgtcgg
     6121 gcgtggccgc cgaccggaac gtccactcgg cgtgcccgcg ggtggcgagc ggccagcggg
     6181 cggcgtcgag cgcggtgtcc gtgaccagct tgtaggtgtg cgcgtcggcg ggcgcgtccc
     6241 acacgtacgc ggtcgaatcg gggttccggt cggccgactc gccgtccacg aacacctccg
     6301 tggtctggct catcccgctg tccgcgctgt acacgtcccc gaagcccgtg tggtcgggcc
     6361 cggagtcgcc ccagccgggc gcgttgaacc ggagggtgtc gcccgcccgt tgctgtcccc
     6421 agccgaggcc ggtgccgagc cacggatgcc agaccggctt gaaccagtcg agcgccgggt
     6481 gtgatccgcc ggtgtagcgg accaggccgc tgcgctcctc cagggtgccg tcgccgaccg
     6541 acaccgactc gtgccagcgc tggccggggc cggtggagac gtagtcggtg cgccgggccg
     6601 ggtagtcgat ccgctcctgg aagccgatgc cgacggggaa cgcgtcggtg atcgagtaac
     6661 ggaactcacc gccggacgcg ggccgcgcgg catggaactc gacgccgatc cgcgcgagtt
     6721 ggcgttcgcc cggccggaac gtgaggtcac ggtccgggat ctggcccgcg tgcccctccg
     6781 acaggtcgta gacgtagggg gtgttgcggg tggccgtcat gtccacgcgt cccgccgcgc
     6841 gcagccgggc ggcgtcggcg gcgttcaccg aggcgatcgg gaaggggcgg tcgctgtcgt
     6901 cgtccgcgcc ccaccaggca ctgagccggc cgggtgtgtc gtcggtgacg aacagcgcct
     6961 tgacgcccgc gtcctgggcg gcctgggcga gggcggtcgg ctcggcgccg tcggcgagac
     7021 gggcgaggac cgccttgccg cgcacgttct tcccggtgaa gtcgccgtcg cccacgtcca
     7081 ccagcgggag cctgctgcgg ccgtcggtga gggtgccgcc ggactgggcc accgcctcgc
     7141 cgatcccctt gacgtccagc aagggctggc cgagccgcca cacggtccgg tactcgaaac
     7201 cgccccgcgt gacgcgtccg gtgggcgcgg cgaagacgct gtcgtacgtc gacggcacct
     7261 gcaccgcgcc gaacaggtcg gagccgccgc cgctgcggtc gtactccatc agcagttgcc
     7321 gggtctcggt gcggcggccg acgtcggcgc gtatctcgcg cagcttccgc ccgtcgaggg
     7381 tgacttcgcg gtcgcggtcg agggtgatct cgggcgcggc gaggaagccg aggccgagcg
     7441 agtcgcggcc gtggccgccg tgcacgtcga ggaaggaggt caggctgtac gtgcccggct
     7501 ggagccggag tcgcagcgtg ccggagtcgc cgacgcgcgc ggggaccggg tcgacgccct
     7561 cggcgagccg ctgcaccgcg aggtcggcgg cggtgccggc cccggagcgg tccttgacgt
     7621 gcacggtgag cgtgtagcgc tcctcctcct tgaccagggc gaacacggtg tgcgcgacgg
     7681 gtgtgccggc cgccgaggcc acgatctgcc cgctggtctc gcccaccggg gcctcgccgg
     7741 cgtcgccggt gaccgtggtg gtcgcggtgc cgtgcgcggg cacggcgagc gcggtgtcgg
     7801 cgagggtggc cacgccctgt ggggcgccct ggacgacgag ggtcaactcg accggctggt
     7861 cggaggtgtt ggtgtaggtg agggtgcggg tgacgggccg gtccgaggag tacggccagg
     7921 cgtggaagcc gaggtcggcg ctgccggtgg cggtgaccgt ggcggtcacg gcgtccggga
     7981 cgctcacccg tcccgcgccc aacgtgtagg cggaggcgtc cagttgcttg gaggtggaca
     8041 tcagcgcgtc cttgaggcgg gcgccgctcc agtccgggtg ctcctgggcg agcagggcgg
     8101 cggccccggc gacgtgcggc gtcgccatgg aggtgccgct catcgtggtg tagtagccgc
     8161 tgccctcggt gagctgggag cgggcggcga ggatgtccac gccgggggcg gcgaggtccg
     8221 gcttgagggc gttgtcgccc gagcggggcc cggcgctggt gaagtaggcg gcctggtcgg
     8281 caaagtccac cgcgccgacg gtcagggcgg cgtcggcggc gcccggcgag ccgatggagg
     8341 acggcgcgcc ggtgttgccg gcggccacca cgaacagggc gccggtctcc gcggagaggg
     8401 tgtcgacggc ctgcgccatc gggtcggcgc cgtcgctggg ctcctcggag ccgaggctca
     8461 tggagacgat ccgcgcgtgc gcgtcccgcg cggcccactc catgcccgcg atgatctgcg
     8521 actcgctgcc ggtgccctgg tcgtcgagca ccttgccgac gacgaggtcg gcgtccgggg
     8581 cgacgccctt ctccgcgccg tcggaggcgg ctccgctgcc gcccacggtg gaggcggtgt
     8641 gggtgccgtg gccgttgcgg tcggcgacct cctcgccctc gacgaagctc ttggactgct
     8701 tgatccggcc ggccaggtcg gggtgggtgg cgtcgacgcc ggtgtcgagg acggcgacgg
     8761 tgacgccctt gccggtgagc ccggcctgcc aggccttcgc cgtgccgatc tgcgcgttgg
     8821 actcggcgag gtcggcggtg acgcggccgt ccagccacac cttgtcgacg ccgtccgccg
     8881 cgaggccccg cgccgtgccg cggcgggtga agtcccgcca gaacacccgc cccttggccg
     8941 cggccacggc ggccccgtgc acgctggcga gggcgcgggt ccgctcggtg ccggggggcg
     9001 tggcggtgcg ggcgcccttg ccgtaggtga cgatcagcgg cagctcgccg gtgcgggagt
     9061 cggcgaggcc ctggcgcagc agcgcgctga cgtcgaacag ccgccggtcc agccggccgg
     9121 cccgcagata cggcagcgcc tcgtccggca cgacgctgat cgcgccgtcc gcgacctggg
     9181 tgcggacggc tccggtggcc ccggcggggc gctggacggt gacggtcttc ttcccgccgg
     9241 cgaggtcggt gacggtgacc ttgtcgccgg tgacgagggt gacggtgcgg ggggtggcgg
     9301 cgggggcggc tgtggaggtg gtcccgagag cgaccgcgga gccggtctcg gggacggtcg
     9361 tggggggctt cgccgtgggg gcggcgccgg cggtctgccg ggcggctgcc tgccccgccg
     9421 gcagcagggc gatcacgagc ccggccgaca ggaggagggt cgctctccgg ccgtctggtc
     9481 ctctgctcat ccgtgcctct cttcgtcgag tgctgcctgt gccgtcgagt gctgggtcga
     9541 gcgctgcgaa gagtgtcagg agacttgtgt tgcaggggag ttgacgtgag gtggcggatg
     9601 cctgccgtgg cgtgttcccg ccaggagcac agcgtgcgat agccgcttat ccggtgctta
     9661 ccaagcccat aaccgtaaaa tgcacccatc tcgcggcccc ccgcccggcc cccttgaacg
     9721 ggcgcccgct ccccggcccc cgcacgattt caaggaggcc gccgaccggc ggccgtctcg
     9781 gtccgcgctc tcgggaggaa ctgccatgac cgccagcctg gagcagttgc gccgctgtca
     9841 cttcgccgtc gatctgggcg cggcccgcac ccgcgtgtac gtcaagggcg tgggcctggt
     9901 cgtcgaccag ccctcggtcg ccgccgtgaa cacccgcacc ggcgcgctga tcgccgtcgg
     9961 cgagttcgcc gagcggatga ccggccgcac ccccgactac atccgcgtgg tccgcccggt
    10021 ctccggcggc acggtcatcg acatcgagat ggcgcagcgc atgctgcggc atctgctcgg
    10081 cgaccggatg cggcgctcgc tgcgccgcaa ggcccggctg cgggcggcgg cctgcacccc
    10141 gcacgacgcc gacccgctgg cgcagcgggc caccatagag acgctggtcg ggctgggcgc
    10201 ccggcgggtg gagctggtgg acacgctgat cgccgccgcc gtcggctgcg ggctgcctgt
    10261 ggagcgcgcc gaggccacca tgatcatggt gtgcggggcc gccgcgaccc aggtcgccgt
    10321 gctctccctc ggctcgatcg tcaccgccga acgcgtcccg gtgggcggcg aggcggtcga
    10381 caacgcgatc gtccagtacc tgcgccacga acacgcgttg atgctgccga gccagtccgt
    10441 acgccccctc cagctggccc tgcacggcac cgggctcacc ccgcagggcc cggcgaccac
    10501 cgagatccac ggccgtgacg tggccacggg actggcccgg tcggtcctgg tggacacggc
    10561 cgccgtacgg gaggccatcc agacgccgct gaccgcggtg ctggacggga tcggcaaggt
    10621 gctgcgcgag tgcccgcccg acctggtcgc cgacctcgtc gaaagcggcc tcacgatggt
    10681 cggcggctcc gccctgctgc cgggcctgga ccagatggtc cgcaaggcca cgggcatgcc
    10741 ggtgcacatc gccgaacgcc ccgacgtctg cgcggtccag ggcctcggcg agatgctgga
    10801 gggccgcatc gagcccctgg tactggaccc gctgggggcg tattag
//
