BGC0000598

BGC0000598: polytheonamide A biosynthetic gene cluster from Candidatus Entotheonella factor

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Location: 5,500 - 20,549 nt. (total: 15,050 nt).
This entry is originally from NCBI GenBank JX456532.1.

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Gene details

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General

Compounds

Genes

RiPP

History

KnownClusterBlast

General information about the BGC

MIBiG accession	BGC0000598
Short description	polytheonamide A biosynthetic gene cluster from Candidatus Entotheonella factor
Status	Minimal annotation: no A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s) Completeness: complete Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks	"poyD and E activities were verified by co-expression with poyA. poy F activity was verified by co-expression with poy A and D."
Biosynthetic class(es)	RiPP (Proteusin)
Loci	NCBI GenBank: JX456532.1
Compounds	polytheonamide A polytheonamide B
Species	Candidatus Entotheonella factor [taxonomy]
References	Metagenome mining reveals polytheonamides as posttranslationally modified ribosomal peptides. Freeman MF et al., Science (2012) PMID:22983711 An environmental bacterial taxon with a large and distinct metabolic repertoire. Wilson MC et al., Nature (2014) PMID:24476823 Solution structure of polytheonamide B, a highly cytotoxic nonribosomal polypeptide from marine sponge. Hamada T et al., J Am Chem Soc (2010) PMID:20795624 Total synthesis of the large non-ribosomal peptide polytheonamide B. Inoue M et al., Nat Chem (2010) PMID:21124508 Polytheonamides A and B, highly cytotoxic, linear polypeptides with unprecedented structural features, from the marine sponge, Theonella swinhoei. Hamada T et al., J Am Chem Soc (2005) PMID:15631460

Chemical products information

polytheonamide A

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C₂₁₉H₃₇₆N₆₀O₇₂S₁

Chemical database entries
PubCHEM

polytheonamide B

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C₂₁₉H₃₇₆N₆₀O₇₂S₁

Chemical database entries
PubCHEM

List of genes involved in compound(s) production

Identifiers	Position	Product	Functions	Evidence	Extra
AFS60634.1 poyK	5500 - 5850 (+)	unknown protein			copy AA seq copy Nt seq
AFS60635.1 poyJ	5963 - 7699 (-)	putative transporter-hydrolase fusion protein	Unknown	Sequence-based prediction	copy AA seq copy Nt seq
AFS60636.1	7888 - 8571 (+)	transposase/integrase			copy AA seq copy Nt seq
AFS60637.1 poyB	8815 - 10806 (+)	C-methyltransferase	Tailoring (Methylation)	Sequence-based prediction	copy AA seq copy Nt seq
AFS60638.1 poyC	10848 - 12860 (+)	C-methyltransferase	Tailoring (Methylation)	Sequence-based prediction	copy AA seq copy Nt seq
AFS60639.1 poyA	12892 - 13329 (+)	precursor peptide	Scaffold biosynthesis	Sequence-based prediction	copy AA seq copy Nt seq
AFS60640.1 poyD	13408 - 15015 (+)	epimerase	Tailoring (Epimerization)	Activity assay Sequence-based prediction	copy AA seq copy Nt seq
AFS60641.1 poyE	15015 - 16217 (+)	N-methyltransferase	Tailoring (Methylation)	Activity assay Sequence-based prediction	copy AA seq copy Nt seq
AFS60642.1 poyF	16192 - 17952 (+)	LanM	Tailoring (Dehydration)	Activity assay Sequence-based prediction	copy AA seq copy Nt seq
AFS60643.1 poyG	17956 - 18288 (+)	chagasin-like peptidase inhibitor	Unknown	Sequence-based prediction	copy AA seq copy Nt seq
AFS60644.1 poyH	18354 - 19325 (+)	C1 peptidase	Activation / processing	Sequence-based prediction	copy AA seq copy Nt seq
AFS60645.1 poyI	19377 - 20549 (+)	hydroxylase	Tailoring (Hydroxylation)	Sequence-based prediction	copy AA seq copy Nt seq

RiPP-specific information

Subclass	Proteusin
Cyclic?	no

Annotation changelog

MIBiG version	Submitter	Notes
1.0	Hidden contributor (ID: CUIZDUBUBVAF27VHF4OZXTI3, no GDPR consent given).	Submitted
2.0	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Migrated from v1.4
3.0	Hidden contributor (ID: OFPWNRO3FNTFB6S6A7RD76XT, no GDPR consent given). Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Corrected organism information Remove leading/trailing whitespace in gene identifiers Corrected gene identifiers Removed trailing newline from comments Fixed gene accession Added versions to gene accessions.
3.1	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Update chemical activity to schema version 2.11

Similar known gene clusters

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