BGC0000598: polytheonamide A biosynthetic gene cluster from Candidatus Entotheonella factor
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Location: 5,500 - 20,549 nt. (total: 15,050 nt).
This entry is originally from NCBI GenBank JX456532.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000598
Short description polytheonamide A biosynthetic gene cluster from Candidatus Entotheonella factor
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "poyD and E activities were verified by co-expression with poyA. poy F activity was verified by co-expression with poy A and D."
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
JX456532.1
5500 - 20549
via Enzymatic assays, Heterologous expression
Compounds
  • polytheonamide A
  • polytheonamide B
Species Candidatus Entotheonella factor [taxonomy]
References
Chemical products information
polytheonamide A Evidence:
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C219H376N60O72S1
Chemical database entries
PubCHEM
polytheonamide B Evidence:
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C219H376N60O72S1
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFS60634.1
  • poyK
 5500 - 5850 (+) unknown protein
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    • AFS60635.1
    • poyJ
    		 5963 - 7699 (-) putative transporter-hydrolase fusion protein
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      • AFS60636.1
      		 7888 - 8571 (+) transposase/integrase
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        • AFS60637.1
        • poyB
        		 8815 - 10806 (+) C-methyltransferase
        • Tailoring
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        • AFS60638.1
        • poyC
        		 10848 - 12860 (+) C-methyltransferase
        • Tailoring
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        • AFS60639.1
        • poyA
        		 12892 - 13329 (+) precursor peptide
        • Scaffold biosynthesis
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        • AFS60640.1
        • poyD
        		 13408 - 15015 (+) epimerase
        • Tailoring
        • Activity assay
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        • AFS60641.1
        • poyE
        		 15015 - 16217 (+) N-methyltransferase
        • Tailoring
        • Activity assay
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        • AFS60642.1
        • poyF
        		 16192 - 17952 (+) LanM
        • Tailoring
        • Activity assay
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        • AFS60643.1
        • poyG
        		 17956 - 18288 (+) chagasin-like peptidase inhibitor
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          • AFS60644.1
          • poyH
          		 18354 - 19325 (+) C1 peptidase
          • Activation / processing
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          • AFS60645.1
          • poyI
          		 19377 - 20549 (+) hydroxylase
          • Tailoring
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          Biosynthesis information
          Annotation changelog

          Entry version: 4

          Date
          Changes
          Submitters
          Reviewers
          2022-10-07
          Update chemical activity to schema version 2.11
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 3

          Date
          Changes
          Submitters
          Reviewers
          2022-09-15
          Corrected organism information
          • (ID: OFPWNRO3FNTFB6S6A7RD76XT)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Remove leading/trailing whitespace in gene identifiers
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Corrected gene identifiers
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Removed trailing newline from comments
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Fixed gene accession
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Added versions to gene accessions.
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 2

          Date
          Changes
          Submitters
          Reviewers
          2019-10-16
          Migrated from v1.4
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 1

          Date
          Changes
          Submitters
          Reviewers
          2015-06-12
          Submitted
          • (ID: CUIZDUBUBVAF27VHF4OZXTI3)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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