Gene cluster description
General MIBiG information on this cluster
|Complete gene cluster sequence?||complete|
|Evidence for cluster-compound connection:||Enzymatic assays, Heterologous expression, Sequence-based prediction|
|Comments:||poyD and E activities were verified by co-expression with poyA. poy F activity was verified by co-expression with poy A and D.|
|Contact for this cluster:||Eric J.N. Helfrich (Institute of Microbiology ETH Zurich)|
1. Freeman MF et al. (2012) Metagenome mining reveals polytheonamides as posttranslationally modified ribosomal peptides. Science 338(6105):387-90. doi: 10.1126/science.1226121. Epub 2012
2. Wilson MC et al. (2014) An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature 506(7486):58-62. doi: 10.1038/nature12959. Epub 2014 Jan 29.
3. Hamada T et al. (2010) Solution structure of polytheonamide B, a highly cytotoxic nonribosomal polypeptide from marine sponge. J Am Chem Soc 132(37):12941-5. doi: 10.1021/ja104616z.
4. Inoue M et al. (2010) Total synthesis of the large non-ribosomal peptide polytheonamide B. Nat Chem 2(4):280-5. doi: 10.1038/nchem.554. Epub 2010 Feb 21.
5. Hamada T et al. (2005) Polytheonamides A and B, highly cytotoxic, linear polypeptides with unprecedented structural features, from the marine sponge, Theonella swinhoei. J Am Chem Soc 127(1):110-8. doi: 10.1021/ja045749e.