Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000601.1:
Cluster 1RiPP16092

BGC0000601, sporulation killing factor skfA biosynthetic gene cluster from Bacillus subtilis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: sporulation killing factor
Exact molecular mass: 2781.3023 Da (M+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
RiPP subclass:
Head-to-tailcyclized peptide (cyclic)
Peptides in this cluster:
RiPP core peptide sequence(s): cmgcwasksiamtrvcalphpamrai
Leader peptide length: 29
Follower peptide length: 26
Peptidase(s) involved in precursor cleavage:

Gene cluster description

sporulation killing factor skfA (BGC0000601). Gene Cluster 1. Biosynthetic class = RiPP. GenBank AL009126, positions 213941-220032. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
Contact for this cluster:Alexey Melnik (UCSD)

Literature references

1. Liu WT et al. (2010) Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis. Proc Natl Acad Sci U S A 107(37):16286-90. doi:
2. Gonzalez-Pastor JE et al. (2003) Cannibalism by sporulating bacteria. Science 301(5632):510-3. doi: 10.1126/science.1086462. Epub 2003 Jun