BGC0000603: cyclothiazomycin biosynthetic gene cluster from Streptomyces hygroscopicus
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Location: 1 - 26,596 nt. (total: 26,596 nt).
This entry is originally from NCBI GenBank FJ472825.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
RiPP
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000603
Short description cyclothiazomycin biosynthetic gene cluster from Streptomyces hygroscopicus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • RiPP (Thiopeptide)
Loci NCBI GenBank: FJ472825.1
Compounds
  • cyclothiazomycin
Species Streptomyces hygroscopicus [taxonomy]
References
Chemical products information
cyclothiazomycin
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C59H64N18O14S7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACS50120.1
  • cltQ
 384 - 734 (+) putative transposase
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  • ACS50121.1
  • cltP
 1056 - 1949 (-) XRE family transcriptional regulator
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  • ACS50122.1
  • cltO
 2031 - 3467 (+) transport protein
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  • ACS50123.1
  • cltN
 3606 - 3941 (+) ethyl tert-butyl ether degradation protein
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  • ACS50124.1
  • cltM
 4077 - 4667 (+) hypothetical protein
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  • ACS50125.1
  • cltI
 5069 - 5647 (+) putative transposase
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  • ACS50126.1
  • cltH
 5831 - 8629 (+) LuxR family transcriptional regulator
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  • ACS50127.1
  • cltG
 8700 - 9827 (-) unknown
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  • ACS50128.1
  • cltF
 9932 - 10957 (-) putative lantibiotic biosynthesis protein
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  • ACS50129.1
  • cltE
 10929 - 13556 (-) lantibiotic dehydratase domain protein
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  • ACS50130.1
  • cltB
 13571 - 15613 (-) putative docking protein
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  • ACS50131.1
  • cltA
 15725 - 15907 (-) unknown prepeptide
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  • ACS50132.1
  • cltC
 16069 - 17757 (-) mcbC-like oxidoreductase
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  • ACS50133.1
  • cltD
 17792 - 19735 (-) putative peptidase containing docking domain
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  • ACS50134.1
  • cltJ
 19897 - 20409 (+) epoxide hydrolase 1
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  • ACS50135.1
  • cltK
 20447 - 20803 (-) putative nitroreductase
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  • ACS50136.1
  • cltL
 20970 - 21206 (+) putative transposase
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  • ACS50137.1
 22135 - 22869 (-) hypothetical protein
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  • ACS50138.1
 22827 - 23168 (-) putative secreted protein
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  • ACS50139.1
 24143 - 24604 (+) hypothetical protein
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  • ACS50140.1
 24601 - 24939 (+) hypothetical protein
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RiPP-specific information
Subclass Thiopeptide
Cyclic? yes
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: FTVL3IN3CWSJUJDTYVJJVU23, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Similar known gene clusters
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