BGC0000603: cyclothiazomycin biosynthetic gene cluster from Streptomyces hygroscopicus
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Location: 1 - 26,596 nt. (total: 26,596 nt).
This entry is originally from NCBI GenBank FJ472825.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000603
Short description cyclothiazomycin biosynthetic gene cluster from Streptomyces hygroscopicus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
FJ472825.1
via Heterologous expression
Compounds
  • cyclothiazomycin
Species Streptomyces hygroscopicus [taxonomy]
References
Chemical products information
cyclothiazomycin Evidence:
Copy SMILES
C59H64N18O14S7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACS50120.1
  • cltQ
 384 - 734 (+) putative transposase
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    • ACS50121.1
    • cltP
    		 1056 - 1949 (-) XRE family transcriptional regulator
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      • ACS50122.1
      • cltO
      		 2031 - 3467 (+) transport protein
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        • ACS50123.1
        • cltN
        		 3606 - 3941 (+) ethyl tert-butyl ether degradation protein
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          • ACS50124.1
          • cltM
          		 4077 - 4667 (+) hypothetical protein
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            • ACS50125.1
            • cltI
            		 5069 - 5647 (+) putative transposase
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              • ACS50126.1
              • cltH
              		 5831 - 8629 (+) LuxR family transcriptional regulator
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                • ACS50127.1
                • cltG
                		 8700 - 9827 (-) unknown
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                  • ACS50128.1
                  • cltF
                  		 9932 - 10957 (-) putative lantibiotic biosynthesis protein
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                    • ACS50129.1
                    • cltE
                    		 10929 - 13556 (-) lantibiotic dehydratase domain protein
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                      • ACS50130.1
                      • cltB
                      		 13571 - 15613 (-) putative docking protein
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                        • ACS50131.1
                        • cltA
                        		 15725 - 15907 (-) unknown prepeptide
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                          • ACS50132.1
                          • cltC
                          		 16069 - 17757 (-) mcbC-like oxidoreductase
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                            • ACS50133.1
                            • cltD
                            		 17792 - 19735 (-) putative peptidase containing docking domain
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                              • ACS50134.1
                              • cltJ
                              		 19897 - 20409 (+) epoxide hydrolase 1
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                                • ACS50135.1
                                • cltK
                                		 20447 - 20803 (-) putative nitroreductase
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                                  • ACS50136.1
                                  • cltL
                                  		 20970 - 21206 (+) putative transposase
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                                    • ACS50137.1
                                    		 22135 - 22869 (-) hypothetical protein
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                                      • ACS50138.1
                                      		 22827 - 23168 (-) putative secreted protein
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                                        • ACS50139.1
                                        		 24143 - 24604 (+) hypothetical protein
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                                          • ACS50140.1
                                          		 24601 - 24939 (+) hypothetical protein
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                                            Biosynthesis information
                                            Annotation changelog

                                            Entry version: 4

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-10-07
                                            Update chemical activity to schema version 2.11
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 3

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-09-15
                                            Updated bioactivity data
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 2

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2019-10-16
                                            Migrated from v1.4
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2019-10-16
                                            Updated compound(s) information (NPAtlas curation)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 1

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2015-06-12
                                            Submitted
                                            • (ID: FTVL3IN3CWSJUJDTYVJJVU23)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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