Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000603.1:
Cluster 1RiPP126596

BGC0000603, cyclothiazomycin biosynthetic gene cluster from Streptomyces hygroscopicus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: cyclothiazomycin A
SMILES string: Copy to clipboard
Molecular formula: C59H64N18O14S7
Exact molecular mass: 1495.2733 Da ([M+Na]+)
Molecular activity: Antifungal, Other
Molecular target: human plasma renin

Class-specific details

Biosynthetic class(es):
RiPP subclass:
Thiopeptide (cyclic)
Peptides in this cluster:
RiPP core peptide sequence(s): SNCTSKGSPASCCSCCCC
Leader peptide length: 42
Follower peptide length: -1
Peptidase(s) involved in precursor cleavage:
Crosslinks in final product:
1=11 AA (Other)
5=18 AA (Thioether)

Gene cluster description

cyclothiazomycin (BGC0000603). Gene Cluster 1. Biosynthetic class = RiPP. GenBank FJ472825. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Detailed annotation

cltA leader / core peptide, putative Class I


Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression
Contact for this cluster:Douglas A. Mitchell (University of Illinois at Urbana-Champaign)

Literature references

1. Cox CL et al. (2014) Nucleophilic 1,4-additions for natural product discovery. ACS Chem Biol 9(9):2014-22. doi: 10.1021/cb500324n. Epub 2014 Jun
2. Zhang P et al. (2014) Regulation of the biosynthesis of thiopeptide antibiotic cyclothiazomycin by the transcriptional regulator SHJG8833 in Streptomyces hygroscopicus 5008. Microbiology 160(Pt 7):1379-92. doi: 10.1099/mic.0.076901-0. Epub 2014
3. Wang J et al. (2010) Identification and analysis of the biosynthetic gene cluster encoding the thiopeptide antibiotic cyclothiazomycin in Streptomyces hygroscopicus 10-22. Appl Environ Microbiol 76(7):2335-44. doi: 10.1128/AEM.01790-09. Epub
4. Aoki M et al. (1991) Cyclothiazomycin, a novel polythiazole-containing peptide with renin inhibitory activity. Taxonomy, fermentation, isolation and physico-chemical characterization. J Antibiot (Tokyo) 44(6):582-8.