LOCUS       BGC0000604             22848 bp    DNA     linear   BCT 01-JUL-2009
DEFINITION  Nonomuraea sp. WU8817 GE2270 gene cluster, complete sequence.
ACCESSION   BGC0000604
VERSION     BGC0000604
KEYWORDS    .
SOURCE      Nonomuraea sp. WU8817
  ORGANISM  Nonomuraea sp. WU8817
            Bacteria; Actinobacteria; Streptosporangiales; Streptosporangiaceae;
            Nonomuraea.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 20:00:20
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 22848
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..714
                     /gene="tpdR"
     CDS             1..714
                     /codon_start=1
                     /gene="tpdR"
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 83.8; E-value: 3.5e-25)"
                     /gene_kind="regulatory"
                     /note="TpdR"
                     /product="TetR transcriptional regulator"
                     /protein_id="ACS83759.1"
                     /transl_table=11
                     /translation="MTARRRDVERVDRIVDAAAELLPERGYRRLTVEEVASRAGVSKSS
                     VYLHWNTKDEIFYAVLDREFTVLAQAAVDRVRRDPAEVLAHRTAANLFQIVACRPLLQA
                     LLVDDRTTLGSLQPAKSAVFRASLANLNELMYRYLHALRINGLLCPEVDPRIMRKAISE
                     MLRGMTFSAGAKPLAETRLAKLSQVVAVTVQRAFEPGDVPELDRINAAAAEVFKAFDEL
                     MPAEETMRAERPVAL"
     source          1..22848
                     /clone="BAC AWU002-A16"
                     /db_xref="taxon:653884"
                     /mol_type="genomic DNA"
                     /organism="Nonomuraea sp. WU8817"
                     /strain="WU8817"
     misc_feature    1..22848
                     /note="GE2270 gene cluster"
     protocluster    1..22848
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[710:18937]"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      711..18937
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
     protocluster    1..22848
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[710:20577]"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /neighbourhood="10000"
                     /product="thiopeptide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      711..20577
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /neighbourhood="10000"
                     /product="thiopeptide"
                     /protocluster_number="2"
     cand_cluster    1..22848
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /detection_rules="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /kind="chemical_hybrid"
                     /product="LAP"
                     /product="thiopeptide"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..22848
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000604"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..22848
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="LAP"
                     /product="thiopeptide"
                     /region_number="1"
                     /rules="((((goadsporin_like or PF00881 or TIGR03605) and
                     (YcaO or TIGR03604)) or TIGR03882 or TIGR03603 or
                     TIGR03602) and not cyanobactin_synth)"
                     /rules="((YcaO or TIGR03604) and ((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or PF07366 or PF06968 or PF04055) or thiostrepton)"
                     /subregion_numbers="1"
                     /tool="antismash"
     misc_feature    313..315
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            711..2612
                     /gene="tpdO"
     CDS             711..2612
                     /codon_start=1
                     /gene="tpdO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     TIGR03604"
                     /gene_kind="biosynthetic"
                     /note="TpdO"
                     /product="cyclodehydratase"
                     /protein_id="ACS83760.1"
                     /sec_met_domain="TIGR03604 (E-value: 5e-102, bitscore:
                     331.7, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 9.3e-74, bitscore: 239.2,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVVRAHVRQEPAALVVGRGLLADRLAAVTGRLDPGVVLAVSDAP
                     DPAVLAEARATGRPVLPVLAEPGRVRVGPLERPGEPGCSDCLSLRRHRAASRSAERAAA
                     WLRHGPDLAATPSPLLAPVALDLVAELVTALVTAPAPAHRGILLADLSDLSVTPHAFLP
                     DPFCPRCGTLPDDDPARARITLVPRPKPSPDRHRVWDAEGRLDRLRQIYVDDHCGLVHS
                     LNPAALGSLAVAGAPIRLRGTTAFEPGFGRSRSYRRSSVIALLEALERYGAIGPGGRRG
                     TVRASYASLGNLAVDPRSLGLHPPEHYALPGFPYRPFTPEAVCRWLWGHSFATGGPVLV
                     PERNVHYGPSDDDRPFCYELANGCALGSCLEEAVFHGILEVLERDAFLLTWYTRARAPR
                     LDLGTARDPTIPLVAAAITAETGYLVECYDITPDHGVPCVWALARHPSDGEPATISAAA
                     AGPGLEPAAAGALAELGPMVPTVRDHFPQHAGRARELAADGRRVRSMIDHYLVYGVRSA
                     ARRLSFLTDGTEEVPFAPAPDGFRHDDLTADLRFLLDRLADSGLDVVVVDLTTPEHRAG
                     GLRCVKVLVPGTVPMTFGEQNRRTWGLPRLLDPAVVRGRGMPVRGHADLNPDPHPFP"
     gene            2609..5098
                     /gene="tpdP"
     CDS             2609..5098
                     /codon_start=1
                     /gene="tpdP"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     55.7; E-value: 3.2e-17)"
                     /gene_kind="biosynthetic"
                     /note="TpdP"
                     /product="dehydratase"
                     /protein_id="ACS83761.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.8e-41, bitscore:
                     132.1, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRHAPPAVARVGGLPAAALHGVACPEATRLAGRVVHLTEELTRR
                     AAVLSDALYEVIGAAGAHKPILVAIRRDLHGLRRPKRVEVLPAPLAEPVRTWISLWEER
                     ARVHAVLPDVLAREERLAWEALRELAATPAVRHGLAHASPDLSADLEKWLADTGWRPRP
                     STLASLLRYVKRVAAKTSPFSTFTTVHEVRWVDGGAAWQVPDTAPTVVVEADVGLRLLV
                     ESVLPRMPEVAAARVVRLSPAAYASGDRLAFPEPGGRMRAVDRTSALDTLVELLRAEQR
                     WDAAIAKLTGAGLAGHGAEDGTRDSASDGTAAAEQVLSGLVRGGLVEAVVPVPGQAARP
                     FARLADWAAPAAPAGPLHRIQVALDQAGPLGDGDPLASACAHVARRLTAELPALGLPVM
                     PVPDLRRRVLRESALGAPVACALREWRPVLADLQRVRRWLAVHDPMLPLRLTLADRVRD
                     WFGPGSAAPLLDVYARVRTAEPGTPLDPDFLEHPDPLAGVTDPRLTRLRELRAASVAAL
                     TGGRAEEALSEPPAWVRDPGPVTCYVQPFQGEDGLRLVLNAAHGGHGRGITRWTRLLGA
                     EPPPGEPPAAESPPGESPPGELPPGACLVAELPGTFGHSLNLHAPATGWELTYPGAVNQ
                     APPERRVPLAELQVRHDAGRGVVELWWPRAGRRVVPVHAGMMSETLLPPLARLLVEAFG
                     TTHLTHPTLPPVVRAAGPRIDLGRVTLARAQWTARREEIPRRGGDDAAHLVAVHAWLRA
                     AGIPRRCFVRVREPQVRRDRLAFDKRHKPVFVDFGSWPSVLEFDRIVTRATGDLELTEA
                     LPDGERAVELAIEIGAR"
     gene            5095..6129
                     /gene="tpdQ"
     CDS             5095..6129
                     /codon_start=1
                     /gene="tpdQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 119.3; E-value: 3.3e-36)"
                     /gene_kind="biosynthetic-additional"
                     /note="TpdQ"
                     /product="cytochrome P450 monooxygenase"
                     /protein_id="ACS83762.1"
                     /sec_met_domain="p450 (E-value: 6e-17, bitscore: 51.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRYPLPRPHPLGIHPGYARLREGCPVARVDSPYGPAWLITRYAD
                     VAAVLTDARYSRAAATEDDGGILLNTDPPEHDRLRRLVVAHTGAAAVERLRPRAEEIAT
                     TLAKRIPAEAEFVSAFAEPYSHRVLALFVGHLVGLPAGELSPMATVLTLARVPDRERAA
                     AFAELRRRLRSQVDDETLAVVLNIVFGGHAAVVAALGYCLLAALAEPLPSLTGDVRRIA
                     ELVEETLRLAPPGDRTLLRRTLEPVELGGRELPAGALVIPSIAAAGRDPDRPTGGPAGR
                     HLAFGRGPHACLGMALARMELRVALQALAEHVPGLRPAVSPATLRRTCEELAVSPLAGI
                     PIRV"
     gene            6218..6904
                     /gene="tpdS"
     CDS             6218..6904
                     /codon_start=1
                     /gene="tpdS"
                     /note="TpdS"
                     /product="hypothetical protein"
                     /protein_id="ACS83763.1"
                     /transl_table=11
                     /translation="MVHAFGVRNRGRIVSAEHHYRDRLRALSAYLRKVDNEPEAAAELR
                     ADPEKALREAGVDQAFDRPEAFRAFVGKLAVLSGEAWLATVHSMIELCEIGADPQPPAG
                     PNISFRISSDGGVTAIANRGEIAKKVQPNPFHAGSAAASPGGRLRIYPGYATSELSARL
                     GERYLSTFYQRTLLKRVVLDPGTVVEDADAGEGITVNRSQYRGVGFELHTRADGADREI
                     VAALVR"
     misc_feature    6446..6448
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6947..8065
                     /gene="tpdT"
     CDS             6947..8065
                     /codon_start=1
                     /gene="tpdT"
                     /note="TpdT"
                     /product="N-methyl transferase"
                     /protein_id="ACS83764.1"
                     /transl_table=11
                     /translation="MLSSALEVDIDEAAVAADLRELAAALDRSGYGEILTCFLPHKAQA
                     HIWAQTAAKIDGPLRTLMELFLLGRAVPQDDLPARVGDLIPGLAATGLVQTGQGAVWLP
                     NLILLRPMGQWLWCQRPHPSPTMYFGDDSLALVHRMVTHRGGHTLDLCAGPGVQALTAS
                     LRSDRVTAVEINPVAAALCRTNIAMNGLGDRMEVRLGDLYGAVPGEVFDDIVSNPPLLP
                     VPEDVQFAFVGDGGRDGFDISWTILDGLPEHLSDRGACRIVGCVLSDGYVPVVMDGLGK
                     WAVEHDFDVLLTVTAHVEAHRDSSFLRSMSLMSSAISGEPADVLQERYAADYAELGGSH
                     VAFYELCARRGGGTARLADVSATKRSAEVWFV"
     gene            8094..9338
                     /gene="tpdU"
     CDS             8094..9338
                     /codon_start=1
                     /gene="tpdU"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: PF04055"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 55.2; E-value: 8.3e-17)"
                     /gene_kind="biosynthetic"
                     /note="TpdU"
                     /product="coproporphyrinogen III oxidase"
                     /protein_id="ACS83765.1"
                     /sec_met_domain="PF04055 (E-value: 8.2e-21, bitscore: 65.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTTLPKTLRGSDGALAEQPLLIYVNVPFCNSKCHFCDWVTEVPL
                     ADLRLTPDSSPRRRYVAALVKQIETHAPTLGGLGYRPEVMYWGGGTASILTIEEIEAVA
                     GALAARFDLGGLVEATIEGSPESMDPGKLKLFRAIGFNRISIGVQAFDDARLRRIGRVH
                     SAEQAERAVRMAADAGFDNINIDLIVGFPGQGADEVSRTIQHAVTLPVNHFSVYPYRPT
                     GGTVMRRQVGRGMGRIDVEEQLRSYDHARDLLARHGFEEYATAYFGAPRCESDEVYYKL
                     TMDWIGFGSGANSLIGTRFLLNDRGGLHRFSTAPHRFDSDTPASAPHLTRHFLAQALTT
                     VDGMDARTFQLRTGRSLRAACEEPAVRRMLEQINRRGRLIVDSRGIRLHRDDMASAYIT
                     MNSVDLYAATEQPGG"
     gene            9462..9635
                     /gene="tpdA"
     CDS             9462..9635
                     /codon_start=1
                     /gene="tpdA"
                     /gene_functions="biosynthetic-additional (thiopeptides)
                     predicted thiopeptide"
                     /gene_kind="biosynthetic-additional"
                     /note="TpdA"
                     /product="GE2270 prepropeptide"
                     /protein_id="ACS83766.1"
                     /transl_table=11
                     /translation="MSELESKLNLSDLPMDVFEMADSGMEVESLTAGHGMPEVGASCNC
                     VCGFCCSCSPSA"
     CDS_motif       9462..9584
                     /prepeptide="leader"
                     /note="peptide class: thiopeptide"
                     /note="predicted sequence:
                     MSELESKLNLSDLPMDVFEMADSGMEVESLTAGHGMPEVGA"
                     /locus_tag="tpdA_thiopeptide"
                     /aSTool="thiopeptides"
                     /tool="antismash"
     CDS_motif       9585..9629
                     /prepeptide="core"
                     /locus_tag="tpdA_thiopeptide"
                     /peptide="thiopeptide"
                     /predicted_class="Type II"
                     /score="31.00"
                     /molecular_weight="1412.7"
                     /monoisotopic_mass="1411.4"
                     /core_sequence="SCNCVCGFCCSCSP"
                     /aSTool="thiopeptides"
                     /tool="antismash"
                     /leader_sequence="MSELESKLNLSDLPMDVFEMADSGMEVESLTAGHGMPEVGA
                     "
                     /leader_location="[9461:9584](+)"
                     /tail_sequence="SA"
                     /tail_location="[9629:9635](+)"
                     /alternative_weights="1430.7"
                     /alternative_weights="1448.7"
                     /alternative_weights="1466.7"
     CDS_motif       9630..9635
                     /locus_tag="tpdA_thiopeptide"
                     /note="tail peptide"
                     /note="thiopeptide"
                     /prepeptide="tail"
                     /aSTool="thiopeptides"
                     /tool="antismash"
     gene            9646..12129
                     /gene="tpdB"
     CDS             9646..12129
                     /codon_start=1
                     /gene="tpdB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     47.2; E-value: 1.2e-14)"
                     /gene_kind="biosynthetic"
                     /note="TpdB"
                     /product="dehydratase"
                     /protein_id="ACS83767.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 9.7e-50, bitscore:
                     159.4, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPAQAGGTPPGVRRQIMEVGREIVVRVAGLPAAVLADLRLPHTA
                     ELVTHLSAERRRLAAEAAALSGELFDLIGAAGSARAALVGLRRALAPGHRPPSPRLIGL
                     CPLPAPLAERVTAWVRARYDWEDRRRDLAGTLDKERADALDRVRAACVAPAFRRGLALS
                     GGELTSTLERWLADPGRAPRQGKVLRLVKYLTRAAAKTSPYGSFMVSALAGRPGDDPPI
                     PELLTVAEPPGAFLDAVGDALLADPALAGQVPLRPNPSLTWTAQGLLFVRTVRAAAGEQ
                     AGPKEEIATAGRAAALELCLRHAESRPTAPQLAELLAEAGADPGEAAAFVDRLVAAQLL
                     LPCPPVHDDDPDPFGAWARQVCAPELRELAAASRPVAAAVDSPGQRRARIAEAAAAVAD
                     RLGIDPPADPAHEHDVSTGRPAPPPLPAGVLADLDAVRRWLAVFDWKVPVRVGVGAFCR
                     ERFGSGSRTPFLEACRAATAALPHLFGPAAMPWFLDLTGDGRLRELDRLRTRARDLARS
                     GVLDRRRVLADTADWPAWLTWPASTGFYLQTLPGGVVLNAVHAGHGRAAGRVHHLLARA
                     GAAPPRPPRSGLPRAEFGGRFGSALNTRTPSTRYEIDHPGATSGRDPRHRVPLGTLMVV
                     HDPDTDLVHLHSDRLGRVEPVHLGMMGELGLPAVAGFLERAFAPTYLFHPSVPPFISLR
                     DLAGASSARRFPRVSVGDVVVQRARWTVPAGLVPARTGADGDHLLALAEWRREHGIPER
                     CFVRGWKPGAALGKARKPLYVDFASWHLVALFEREARTNAALVIDEALPDPLADGAPAH
                     VTEYHVEIGDREREQ"
     gene            12126..13025
                     /gene="tpdC"
     CDS             12126..13025
                     /codon_start=1
                     /gene="tpdC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /note="TpdC"
                     /product="dehydratase"
                     /protein_id="ACS83768.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.4e-47, bitscore:
                     152.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTERPGWFAAHVHYRGDLDALLREAVAPLVRALAADFFFLRYWDG
                     GSHLRLRLRGGDQVAVARHLDAYLAAHPAPETTSQEEYARVAPVLAAREGMTGHLTTLR
                     PNNTVEFAAYRPETAKYGTGDALRAVERHFVESSRYALDVLDRRPTGNQRELAVLGVLL
                     LAWYAARPLDEPPGEPVDDELIGAVEALCRGWRGGRDLPEELVAEEYGRVRERVAGLAG
                     ALRDLVPDPDAPGSSMRAWAATFDRLAAALPPPDRLRVLDTCAHLAANRLGVSMAAEVR
                     LRLLAARALREVAPVGRR"
     gene            13025..14026
                     /gene="tpdD"
     CDS             13025..14026
                     /codon_start=1
                     /gene="tpdD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /note="TpdD"
                     /product="hypothetical protein"
                     /protein_id="ACS83769.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.3e-36, bitscore:
                     116.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSWRRVDVAYHDPDLDGLILATRPLLAGTPGRGWFQRHWVRGPHL
                     ELWFDAAQPSWERIRDVLEPWLRVNPSRARIDRDRLLAQHRHLAAAERIDEPLLPFYAD
                     NTLHRAAPRSRAHVLGGPAAEELFHDFHTTASAVAYDELDAVRAGESRLVMALDLMVAA
                     AHAHAEGGVRGGFVSFRSHAEAFLASAPGLRERWDAEYAARAGALRARITAVVAGIPRG
                     RAWAGLLDRFADRGDELIASGALLVEPAGPDAVARPDTAFHRALRGNRTWHEEVLRSAP
                     FRRYRLLLNLTYLQLSRLGVNAVQRALLCHFAASAVEQEYGVSAIEIAMGGA"
     gene            14023..15390
                     /gene="tpdE"
     CDS             14023..15390
                     /codon_start=1
                     /gene="tpdE"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_kind="biosynthetic"
                     /note="TpdE"
                     /product="dehydrogenase"
                     /protein_id="ACS83770.1"
                     /sec_met_domain="PF00881 (E-value: 1.5e-11, bitscore: 34.9,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMSVQVEPAVTHRWALRPGVYRATAPGGDLMLAAWPHATPLGRAT
                     PELLALLDGLAAGSLPLDEPGDLAPAVELLRAGGWLRKTVAYAGRDLYTITPVAAPTDA
                     PPPPRDEPALSRFALLRNTADGLVLEMPGSWCDVHVHDPAVAALLADPSGDGGLPAEAA
                     AALRADLAAAGMLMEREEPFERRQWSTHELWFHERSRLGNRGWFGAHFGGTFWARGRHD
                     PPPARPSPYPGPAVELARPDLAALRRTDPTLTAVLEDRESVRDHDDDDPISAEQLGELL
                     YRCARVRLLRHLEGFEYAGKPYPAGGSAYELEVYPVVRLARGLDPGMYHYDAHDHRLRQ
                     VRPAGHPAVRRMLKVATESSVAKAPPQVLLVISARVGRILWKYEAMGYALMLKHVGVLQ
                     QTLYAVATAMDLAPCALGSGDDLAFTAATGRDRLVECAVGEFMVGSRRKEPAAWEL"
     gene            15378..17204
                     /gene="tpdF"
     CDS             15378..17204
                     /codon_start=1
                     /gene="tpdF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Heterocycloanthracin_C_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic"
                     /note="TpdF"
                     /product="hypothetical protein"
                     /protein_id="ACS83771.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 6e-23,
                     bitscore: 71.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     5.8e-13, bitscore: 38.9, seeds: 5, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MGALNLLLRPDAHYAEVDGGVYVLSHQGETFISGTSVHRWLDRLA
                     PLLDGTRTLDQLTAGLPADRAGFVARLVGTLTERGLVREVGPAVSDTLTDAERGEHRAL
                     LAYLGYFHDSPGRVLEDVRDTPTAIVGSGPLAAAVVRACAAAGLRRVEIGEEAGAARVV
                     VHVAERAEPERAARLERRCAAEGVLLAQVMPGPDGIWWQPAARGGCWASAWRRHRALAG
                     VDRTGTPLDPVAVAVVAGQVAHDVFRVLAGLREEAPPRLVVLDPRTLASTAHPVVAHPF
                     ELPAAPLDEAAFLDRVAALRAAPALSEAEFSRRAKGLMDSTVGLFAEIDEGDLAQLPLH
                     VTATTVADPCGLIGSAPRPVVTGAGLTFEEARYRAARAALALAGTLALDRRRLVDGRVW
                     AYDLADGAARLVPADEVFASTAGGSTAGVPLGAAAAYSWAEAVAEGLVAQAAALTLAGA
                     GHAGEPYGRADLAGAPAYLLAMVRALGEELTVHDVTGPLGVPVVVGTLSGGATACGAGM
                     TTDAAVTACLRDLLLLRQAEINDQPVYAPPSGRPLPGHLRGNHPAPAVPGTDADRLAAR
                     LAERGHRPLAVPLDHDQAVHAVLPFAVRVVCR"
     gene            17201..18937
                     /gene="tpdG"
     CDS             17201..18937
                     /codon_start=1
                     /gene="tpdG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     TIGR03604"
                     /gene_kind="biosynthetic"
                     /note="TpdG"
                     /product="cyclodehydratase"
                     /protein_id="ACS83772.1"
                     /sec_met_domain="TIGR03604 (E-value: 6.9e-99, bitscore:
                     321.3, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 8.7e-74, bitscore: 239.3,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRLPDHGELAVPIGDGPMLPLRTELGRVVIGPLERPGVPGCRAC
                     VRIRAARVQPDARKAEAVRARHAPAPSQWLTPLATDLVRVLVASESAALAADTDPRTAG
                     AVLEIDLATLEITRHRFLPDPLCPHCGGLPPDGPAELTLRPRRKLGGSPRTRPVELNAL
                     LETYVDGRVGMIRPLKSGVQGGLTVASAMLPIRAGHGLEPGVGRTRSYTASRLVAVLEA
                     LERYGGVSPGGRRTSVTAAYRDISGHAVHPDTFGTHPEENYDRPGFAFRRFTEDTVCRW
                     VWGYSFAKAQPVLVPENQVYYYARNLPDGEQPFVFEVSNGCALGSCLEEAILHGLLEVV
                     ERDAFLLTWHARREVPVLNPALASDPVLPMQAAAITAETGHRVLCFDTTAEHGIPSVWA
                     MAVDVEHRSDRPATAHAAGAALTLEQAAMNALSELGPLLADVIRRYPEERERAEAMVRD
                     PEQVATMHDHSLLYAVPAAAERLSFLTGRADGPRTGFGSARFTGDDLTADLRAMIDAVI
                     DAGMDVVVVDQTTPEHLAGGFRCVKVLVPGALPMTFGHQYRRLDNLPRLAAARTTDPHP
                     FP"
     gene            18969..19337
                     /gene="tpdK"
     CDS             18969..19337
                     /codon_start=1
                     /gene="tpdK"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: thio_amide"
                     /gene_kind="biosynthetic"
                     /note="TpdK"
                     /product="hypothetical protein"
                     /protein_id="ACS83773.1"
                     /sec_met_domain="thio_amide (E-value: 2.3e-38, bitscore:
                     120.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYVVIVAFDLKESSVDFAELRAWVRDRAADDYSRLPGMRFKTWFS
                     DERKRLWGAVYLVESMLSFDRDNLPLLPDGRTGPVGTRPTSVMVLELEAFVTGPDGLDG
                     IEALARQGLSMTGGGHDH"
     gene            19327..20577
                     /gene="tpdL"
     CDS             19327..20577
                     /codon_start=1
                     /gene="tpdL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: PF04055"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 58.8; E-value: 6.7e-18)"
                     /gene_kind="biosynthetic"
                     /note="TpdL"
                     /product="coproporphyrinogen III oxidase"
                     /protein_id="ACS83774.1"
                     /sec_met_domain="PF04055 (E-value: 1e-20, bitscore: 65.0,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTEATTAVTTRANAGALSLPARGTDRPLLLYVNIPFCNSKCHFC
                     DWVVDVPVSDLRLAPAAPRRVDYLAALCTQIRTHAPALRAAGYRGEVMYWGGGTATVLT
                     AAEIEQVHACLAAEFDLTALAEATIEGSPESVDPAKLRLLRDLGFDRVSLGVQSFDETR
                     LRRIGRAHSAGQAVRSVEDAHAAGFDNINIDLIVGFPDQSLAEVEQTVRRALDLPVNHF
                     SVYSYRATEGTVMRRQIERSGTAIELEHQLQSYRLAGEMLAAAGHPEYAVSYFGAPRCL
                     ADEAYYRLSMDWIGFGTGANSLINQRYLLNGRGRMRDFTSRPGEFEVDLPAGVPSLTVQ
                     WLPRALGTAEGIDAATFQRRTGTSLRAACEEPELNAFLTRVNEFGRLVVDRDGIRLADE
                     NRSDVLSRTFAAMGWVS"
     gene            20579..21598
                     /gene="tpdM"
     CDS             20579..21598
                     /codon_start=1
                     /gene="tpdM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 284.2; E-value:
                     2.4e-86)"
                     /gene_kind="biosynthetic-additional"
                     /note="TpdM"
                     /product="O-methyl transferase"
                     /protein_id="ACS83775.1"
                     /transl_table=11
                     /translation="MEAMRTLLAAADLVTPMALRVSATLRLADHLAAGTTGAAELAAAA
                     GVDEAALTRLLRYLVARGVFTEPAPGEFGLNPAAELLRDGRPDRLRDWLDLTGPIGRAD
                     LAFGSLLDVVRTGKPGYPMIHGRGFWDDLAAEPALATAYDTLMGGKRQWAATTLAALDW
                     SRSRHVVDVGGGNGTLLSCLLAAHPHLRGTVVDRPTSAKAAGAVLASAGVADRGEFRAG
                     DFFEPLPVHGADTYLLSSILHDWDDAAATAILRRCAEAAAPGGRVLLCELVAMAGPDRR
                     TVTHMDLCMLVYFGGRERTAADFAALAGAAGLEPRSVTPLPPHDWGNALVEYAVPAAR"
     gene            22234..22848
                     /gene="tpdN"
     CDS             22234..22848
                     /codon_start=1
                     /gene="tpdN"
                     /note="TpdN"
                     /product="deaminase reductase"
                     /protein_id="ACS83776.1"
                     /transl_table=11
                     /translation="MAKVISTLFISADGVAEIDPDWHFPYFDENMGRAVGEDYDTADVL
                     LIGRETFDSFAGAWPDREAAGGDDAPFAKQLGDMRKVVVSRQPLEFSWRNCELITGDLL
                     DAVTSLKADAGIRGILIPGSISVVQQLLAAGLVDELRLLVHPVAARKGRRLFDDGDAPY
                     HLSVTATETFPTGVIRVIYSPTEAPTKVGYDEVEAQVSTGE"
ORIGIN
        1 gtgacggcgc ggcgacgcga cgtcgaacgg gtggatcgga tcgttgacgc ggcagcggaa
       61 ctgctgcctg agcggggata tcggcgactg acggtcgagg aggtcgcaag ccgggcgggc
      121 gtctccaaaa gcagcgtcta cctgcactgg aacaccaagg acgaaatctt ctacgccgtg
      181 ctggaccgcg agttcaccgt gctggcgcag gcggccgtgg accgggtcag gcgcgatcca
      241 gccgaggtgc tggcgcaccg gacggcggcc aacctcttcc agatcgtcgc ctgccggcca
      301 ctgctacagg cgttactcgt cgacgaccgg acaacgctcg gatcgctgca acccgcgaaa
      361 tctgctgttt tccgggccag cctcgcgaat ctcaacgaac tgatgtatcg ctatcttcac
      421 gcgctacgca taaacggact tctctgcccc gaggtcgacc cgcgtattat gcggaaagcg
      481 atttctgaaa tgctgcgcgg aatgacgttc tccgcgggcg cgaaaccgtt ggccgagaca
      541 cggctggcca agttgtccca ggtcgtcgcg gtgaccgtgc agcgcgcctt cgaaccgggc
      601 gacgtgcccg aactcgaccg gatcaacgcc gccgcggcgg aggtgttcaa ggcgttcgac
      661 gagctcatgc cggccgagga gacgatgcgc gccgaacgcc cggtggcgct gtgaccgtgg
      721 tgcgcgcgca cgtccgccag gagccggccg cgctcgtcgt cggtcgcggc ctgctcgccg
      781 accggctcgc ggcggtgacc ggccggctag accccggagt ggtgctcgcg gtgtcggacg
      841 cgccggaccc cgccgtgctc gcggaggcca gggcgacggg ccggcccgtg ctgcccgtgc
      901 tcgccgagcc gggccgggta cgggtcgggc cgctggaacg gccgggcgag ccgggctgct
      961 ccgactgcct gagcctgcgc aggcaccgcg ccgccagccg gtcggccgaa cgggccgccg
     1021 cctggctccg gcacggcccg gacctggccg ccacgccctc gccgctgctc gcgccggtgg
     1081 cgctcgacct ggtggccgag ctggtcaccg cgctggtcac cgcccccgcg ccggcccacc
     1141 gtggcatcct gctggccgac ctgtccgacc tgagcgtgac accgcacgcc ttcctgcccg
     1201 atccgttctg cccgcgctgc ggcaccctgc ccgacgacga cccggcgcgg gcgcggatca
     1261 cgctcgtgcc gcgcccgaaa ccgtcgccgg accggcaccg ggtgtgggac gccgaaggcc
     1321 ggctcgaccg gctcaggcag atctacgtcg acgaccactg cggcctggtc cactcgctca
     1381 acccggccgc gctgggctcg ctcgccgtcg ccggtgcgcc gatccggctg cgcggcacca
     1441 ccgccttcga acccggattc ggccgctccc gcagctaccg ccggagctcc gtcatcgcgc
     1501 tgctcgaagc cctggaacgg tacggcgcga tcggtcccgg tggcaggcgc ggcaccgtgc
     1561 gcgccagcta cgcctccctc gggaacctgg cggtggatcc caggtcgctg gggttgcacc
     1621 cgcccgagca ctacgcgctg ccgggcttcc cctaccggcc gttcaccccg gaagcggtgt
     1681 gccgctggct gtgggggcac tcgttcgcca ccggcggccc ggtgctggtg cccgagcgca
     1741 acgtccacta cggcccgtcc gacgacgatc ggccgttctg ctacgagctc gccaatggct
     1801 gcgctctcgg ctcgtgcctg gaggaggccg tcttccacgg cattctggag gtgctggaac
     1861 gcgacgcgtt cctgctgacc tggtacaccc gcgcccgcgc gccgcggctc gacctcggca
     1921 ccgcccgcga ccccacgatc ccgctggtcg ccgccgcgat cacggcggag accggctatc
     1981 tcgtcgagtg ctacgacatc acgcccgacc acggggtgcc ctgcgtgtgg gcgctggccc
     2041 gccatccttc cgacggcgag ccggccacga tcagcgccgc ggcggccggc cccggcctgg
     2101 aacccgccgc cgccggcgcg ctggccgagc tcggaccgat ggtgccgacc gtgcgcgacc
     2161 acttcccaca gcacgccggc cgggcgcggg agctggccgc ggacggccgg cgggtgcgat
     2221 ccatgatcga ccactatctc gtgtacggcg tgcggtcggc ggcacgccgc ttgtcgttcc
     2281 tcaccgacgg cacggaggag gtgcccttcg cgcccgcacc ggacggcttc cggcacgacg
     2341 acctcaccgc cgacctgagg ttcctcctcg accggctggc ggacagcggg ctcgacgtgg
     2401 tcgtggtgga cctgaccacg ccggagcacc gcgcgggcgg gcttcgctgc gtgaaggtgc
     2461 tggtgcccgg tacggtgccg atgacgttcg gcgagcagaa ccgccgcacg tggggcctgc
     2521 cgaggctgct cgacccggcc gtggtgcggg ggcgcggcat gccggtacgc ggccacgctg
     2581 atctgaaccc cgacccccac cccttcccgt gagccgccac gcgccgcccg ccgtcgcccg
     2641 ggtgggcggg ctgccggccg ccgcgctgca cggggtggcc tgccccgagg cgacccggct
     2701 cgccggccgc gtggtccacc tcaccgagga gctgacccga cgcgccgcgg tgctgtccga
     2761 cgctctctac gaggtgatcg gcgccgccgg cgcgcacaag ccgatcctgg tggcgatccg
     2821 ccgcgacctg cacgggctgc gccggcccaa acgcgtcgag gtgctgcccg cgccgttggc
     2881 cgagccggtc cggacgtgga tctcgctgtg ggaagagcgc gcccgcgtcc acgccgtgct
     2941 gccggacgtg ctcgcccgcg aggagcgctt ggcctgggag gcgctgcggg agctcgccgc
     3001 gaccccggcg gtgcggcacg ggctcgcgca cgccagcccg gacctctccg ccgacctgga
     3061 gaaatggctc gccgatacgg ggtggcggcc gcgaccgagc acgctggcga gcctgctgcg
     3121 gtacgtgaag cgcgtggcgg ccaagacgag ccccttcagc acgttcacca ccgtccacga
     3181 ggtccgctgg gtggacggcg gcgcggcctg gcaggtgccg gacacggcgc cgaccgtggt
     3241 ggtggaggcc gacgtggggc tccggctgct ggtcgagtcc gtgctgccgc gcatgcccga
     3301 ggtggccgcc gcgcgggtgg tgcggctgtc gccggccgcg tacgcgtcgg gggaccggct
     3361 ggcgttcccg gaaccgggcg ggcggatgcg cgcggtggac cggacctccg cactggacac
     3421 cctggtcgag ctgctgcgcg ccgagcagcg gtgggacgcg gcgatcgcca agctcaccgg
     3481 tgccggcctg gcaggccacg gagcagagga cggtacgcgt gacagcgcga gcgacggaac
     3541 ggcggcggcc gagcaggtgc tgagcgggct ggtgcgcggc gggctggtgg aggccgtcgt
     3601 gccggtgccc ggccaggcgg cccgtccgtt cgcgcgcctc gccgactggg cggcgcccgc
     3661 tgcgcccgcc ggcccgctgc accgtatcca ggtggccttg gaccaggccg ggccgctcgg
     3721 cgacggcgac ccgttggcgt cggcctgcgc ccacgtggcc cgccgcctca ccgccgaact
     3781 ccccgccctg ggcctgcccg tcatgccggt gcccgacctg cgccgtcgtg tgctgcgcga
     3841 gtcggcgctc ggcgcgccgg tcgcctgcgc gctgcgggag tggcgacccg tgctggccga
     3901 cctccaacgg gtccgccgct ggctcgccgt gcacgacccg atgctgccgc ttcgcctcac
     3961 cctggccgac cgggtacgcg actggttcgg ccccggctcg gccgcgcccc tgctggacgt
     4021 gtacgccagg gtccggaccg ccgaaccggg cacgcccctg gatcccgact tcctcgaaca
     4081 ccccgacccg ctcgccggcg tcaccgaccc gcgcctgacc cgcctgcgcg agctgcgcgc
     4141 cgcgtcggtc gccgcgctca ccggggggcg ggcggaggag gcgctgagtg agccgccggc
     4201 ctgggtacgc gatccggggc cggtcacctg ctatgtccag ccgttccagg gggaggacgg
     4261 cctgcggctg gtcctcaacg ccgcccacgg cggtcacggc cggggcatca cccgctggac
     4321 caggctgctg ggcgccgagc cgccgcccgg cgagcccccg gctgccgagt ccccgcccgg
     4381 tgagtccccg cccggtgagc tcccgcccgg tgcgtgcctg gtcgccgagc tgccgggcac
     4441 gttcggccac agcctcaacc tgcacgcgcc cgccaccggc tgggagctga cctacccggg
     4501 cgcggtgaac caggccccgc cggagcgccg cgtcccgctg gccgagctcc aggtccggca
     4561 cgacgccggg cgaggcgtcg tcgagctgtg gtggccgcgc gccggccggc gcgtcgtgcc
     4621 ggtgcacgcc ggcatgatgt cggagacgct gctgccgccc ctggcccgcc tgctcgtcga
     4681 ggcgttcggc accacccacc tcacccatcc gaccctgccg cccgtggtgc gggccgccgg
     4741 tccgcgcatc gacctgggcc gcgtcacgct cgccagggcc cagtggacgg cccgccgcga
     4801 ggagattccg cggcggggcg gcgacgacgc cgcccacctc gtcgccgtcc acgcctggct
     4861 gcgcgccgcc gggatcccgc gccgctgctt cgtccgcgtc cgcgaaccgc aggtgcggag
     4921 ggaccggctc gccttcgaca agcggcacaa gccggtgttc gtcgacttcg ggagctggcc
     4981 gtcggtgctg gagttcgacc ggatcgtcac ccgggccacc ggggacctgg aactgaccga
     5041 ggcactgccc gacggcgagc gggcggtgga gctggcgatc gagataggag cccggtgacg
     5101 cggtacccgc tgccccgccc ccaccccctc ggcatccacc ccggctacgc ccggctgcgc
     5161 gagggctgcc ccgtcgcgcg ggtcgactcg ccgtacggtc cggcctggct gatcacccgg
     5221 tacgccgatg tggcggcggt actcaccgac gcccggtaca gccgcgcggc ggcgacggag
     5281 gacgacggcg gcatcctgct caacaccgac ccgcccgagc acgaccggct gcgcaggctc
     5341 gtggtggcgc acaccggcgc cgccgccgtc gagcggctcc ggccgcgggc cgaggagatc
     5401 gccaccaccc tggcgaaacg catcccggcg gaggccgagt tcgtaagcgc gttcgccgag
     5461 ccgtactcac atcgggtgct cgcgctgttc gtcgggcacc tggtcggcct gccggccggc
     5521 gagctgagcc cgatggccac cgtgctcacg ctggcgcggg tgcccgaccg ggagcgggcg
     5581 gcggcgttcg ccgaactgcg ccggcggctg cggagccagg tggacgacga gacgctcgcc
     5641 gtggtgctca acatcgtctt cggcggccac gcggcggtgg tggccgcgct gggctactgc
     5701 ctgctcgcgg cgctggccga gccgctgccg agcctgaccg gcgatgtccg gcggatcgcc
     5761 gagctggtcg aggagacgct gcgcctggct ccgcccggcg accggaccct gctgcgccgc
     5821 accctcgagc ccgtcgagct gggcgggcgg gagctgcccg cgggagcgct ggtgatcccg
     5881 tcgatcgcgg cggccggccg ggatccggac cggcccaccg gcgggccggc gggccggcac
     5941 ctggcgttcg gccgcggccc gcacgcgtgc ctcggcatgg cgctggcccg gatggagctc
     6001 cgggtcgcgc tccaggcgct ggccgagcac gtccccggac tgcggccggc ggtcagcccg
     6061 gccacgctca ggcgtacgtg cgaggaattg gcggtcagcc cgcttgcggg aatcccgatt
     6121 cgggtgtagt gggcagaaaa ccgaataaac gaatttggtc agcgggtgcc cattccttgc
     6181 cgcggatcac gcccgggtca tactctcggt tccagaaatg gtgcacgcat tcggtgtgag
     6241 aaaccgaggg agaatcgtgt ccgcagaaca ccattatcgt gacaggctac gcgccctgtc
     6301 cgcatatcta cgcaaggtcg acaatgagcc ggaggccgcc gccgagctgc gcgctgaccc
     6361 ggaaaaggcc ctccgggagg ccggcgtcga ccaggcgttc gaccgccctg aagcgttccg
     6421 cgcatttgtc ggaaaactgg cggtattaag cggagaagca tggctcgcga ccgttcactc
     6481 gatgattgaa ctgtgtgaga tcggtgcgga tccgcagcct cctgctgggc ccaacatctc
     6541 attccgcata tcttccgacg gcggggtgac ggccatcgcc aatcgcggtg agatcgccaa
     6601 gaaggtgcag cccaacccct ttcacgccgg ctccgccgcc gcgtcgccgg gcggccggct
     6661 gcgcatctat cccggctacg ccaccagcga actgtcggcc cgcctcggtg agcgctacct
     6721 gtccacgttc taccagcgca ccctgctcaa gcgcgtcgtg ctcgacccgg gcaccgtggt
     6781 cgaggacgcc gacgccggtg agggcatcac cgtcaaccgg tcacagtacc gaggcgtcgg
     6841 gttcgaactg cacaccaggg ccgacggcgc ggaccgcgag atcgtcgccg cgctcgtgcg
     6901 ctgacccccg gcacgagatc acgacatcac accccacgga ggcgggatgc tgagcagcgc
     6961 gctcgaagta gacatcgacg aggcggccgt cgccgccgac ctcagggaac tggccgcggc
     7021 gctcgaccgc agcggctacg gcgagatcct gacgtgcttc ctgccgcaca aggcgcaggc
     7081 gcacatctgg gcgcagaccg ccgcgaagat cgacggtccg ctacggacac tgatggagct
     7141 cttcctgctc ggccgggcag tgccgcagga cgacctgccg gcccgggtcg gcgacctcat
     7201 ccccgggctc gccgccacgg gcctggtgca gaccgggcag ggcgcggtgt ggctgcccaa
     7261 ccttatcctg ctgcggccga tgggccagtg gctgtggtgt cagcgcccgc acccgtcgcc
     7321 cacgatgtac ttcggcgacg actcgctcgc gctggtgcac cgcatggtga cccatcgcgg
     7381 cggccacacc ctcgacctgt gcgcggggcc gggcgtgcag gcgctgaccg cctcgctgcg
     7441 cagcgaccgc gtcaccgccg tcgagatcaa ccccgtcgcc gccgcgctgt gccgcaccaa
     7501 catcgccatg aacggcctgg gcgaccggat ggaggtccgc ctcggcgacc tctacggcgc
     7561 ggtgccgggc gaggtcttcg acgacatcgt gtccaacccg ccgctgctgc cggtgcccga
     7621 ggacgtccag ttcgccttcg tcggcgacgg tggccgcgac ggcttcgaca tctcctggac
     7681 catcctcgac ggcctgcccg aacacctgtc cgatcgcggt gcgtgccgga tcgtcggctg
     7741 cgtgctcagc gacggctacg tgcccgtcgt gatggacggg ctcggcaagt gggccgtcga
     7801 acacgacttc gacgtgctgc tcaccgtcac ggcgcacgta gaggcgcacc gcgactcgtc
     7861 gttcctgcgc agcatgtcgc tgatgtccag cgcgatctcg ggcgagccgg ccgacgtcct
     7921 gcaggagcgc tacgccgccg actacgccga gctgggcggc tcccacgtgg ccttctacga
     7981 gctgtgcgcg cggcgcggcg gcggcacggc acggctcgcc gacgtctcgg cgaccaagcg
     8041 ctccgccgag gtctggttcg tctgacgcca cccaccgacc ggacgggacc gcgatgccga
     8101 ccacactccc gaagaccctg cgcgggtcgg acggcgcgct cgccgagcag ccgctgctca
     8161 tctacgtgaa tgtgccgttc tgcaactcaa aatgtcactt ctgcgactgg gtgaccgagg
     8221 ttccgctggc ggatctgcgg ctcacgccgg actcgtcgcc acgccgccgc tacgtcgccg
     8281 cgctggtcaa gcagatcgag acgcacgcgc cgacgctggg cggactcggc taccggcccg
     8341 aggtcatgta ctggggcggc ggcacggcca gcatcctcac catcgaggag atcgaggcgg
     8401 tggctggggc gctggcggcg cggttcgacc tcggcggcct ggtcgaggcc accatcgagg
     8461 gcagcccgga gtccatggac cccggcaagc tgaagctgtt ccgtgcgatc gggttcaacc
     8521 ggatcagcat cggggtgcag gcgttcgacg acgcgcgcct gcgccgcatc ggccgggtgc
     8581 acagcgccga gcaggcggag cgcgcggtcc ggatggccgc cgacgccggc ttcgacaaca
     8641 tcaacatcga cctcatcgtc gggttccccg ggcagggcgc cgacgaggtg tcgcgcacga
     8701 tccagcacgc ggtgacgctg ccggtcaacc acttctcggt ctacccctac cggccgaccg
     8761 gcggcaccgt gatgcgccgg caggtgggcc gcggcatggg ccggatcgac gtggaggagc
     8821 agctccggtc gtacgaccac gcccgcgacc tgctcgcccg gcacgggttc gaggagtacg
     8881 ccaccgccta cttcggcgct ccccgctgcg agtccgacga ggtctactac aagctcacga
     8941 tggactggat cgggttcggc tccggggcca actccctcat cgggacccgc ttcctgctga
     9001 acgaccgggg cgggctgcac cgcttcagca cggccccgca ccgcttcgac tccgacaccc
     9061 cggcctcggc cccccacctg acacgccact tcctggccca ggcgctgacc acggtcgacg
     9121 gcatggacgc gcgcaccttc cagctgcgca ccggccgttc gctgcgggcg gcgtgcgagg
     9181 agcccgcggt gcgccggatg ctcgaacaga tcaaccgccg cggcaggctg atcgtcgact
     9241 cacgcggcat ccggctgcac cgcgacgaca tggcctcggc ctacatcacc atgaacagcg
     9301 tcgatctgta cgccgcgacc gagcagcccg gcggatgacc gcggtcctgc gcgcctgctc
     9361 acacagtctt cgtgaacccg tgtgcccttc ccacgtgggg acgggcgtgc cggtcgaccg
     9421 ccgcgggctc gcgaaggaat gagggtcaca acggaaagga gatgagcgag ttggaatcca
     9481 agctgaacct tagcgacctg cccatggacg tcttcgagat ggccgacagc ggcatggagg
     9541 tcgaatccct caccgcaggc cacgggatgc ccgaggtagg cgcttcctgc aactgcgtgt
     9601 gcggcttctg ctgctcctgc agcccgtccg cgtagcagtc aaggagtgcc gccggcccag
     9661 gccggcggca ctccgcccgg ggtgaggaga cagatcatgg aggtgggccg cgaaatcgtg
     9721 gtccgcgtgg cggggctgcc cgccgccgtg ctcgccgacc tgcgcctgcc gcacaccgcc
     9781 gagctcgtca cgcacctgtc cgctgagcgg cggcggctcg ccgccgaggc ggctgcgctg
     9841 tccggcgagc tgttcgacct gatcggcgcc gccggctccg cccgcgccgc cctggtgggc
     9901 ctgcggcgcg cgctcgcccc cgggcaccgc cccccgtcgc cgcgactgat cgggctgtgt
     9961 cccctgcccg ccccgctggc cgagcgggtc accgcctggg tgcgggcccg gtacgactgg
    10021 gaggaccggc gccgcgacct tgccggcacg ctggacaagg agcgcgccga cgcgctcgac
    10081 cgcgtacgcg ccgcctgcgt cgccccggcg ttccggcggg gtctggcgct gtccggtggg
    10141 gagctgacca gcacgctgga gcgctggctc gccgaccccg gccgtgcgcc ccggcagggg
    10201 aaggtgctcc gcctggtcaa gtacctgacc cgagctgcgg ccaagaccag cccgtacggc
    10261 tccttcatgg tcagcgcgct ggcggggcgg cccggcgacg accctcccat cccggagctg
    10321 ctcaccgtgg ccgagccgcc gggggcgttc ctcgacgccg tcggcgacgc gctgctcgcc
    10381 gacccggcac tggccggcca ggtgccgctg cgccccaacc ccagcctgac gtggaccgcc
    10441 caaggactgc ttttcgtccg gaccgtccgc gcggcggcgg gagagcaggc cgggccgaag
    10501 gaagagatcg ccaccgccgg gcgcgccgcc gcgctggagc tgtgcctgcg gcacgccgag
    10561 tcccggccca ccgcgccgca gctggcggag ctgctggccg aggcgggggc ggatccgggc
    10621 gaggcggccg cgttcgtcga ccggctggtg gcggcgcagc tcctgctgcc gtgtccgccg
    10681 gtgcacgacg acgatcccga cccgttcggt gcctgggccc gccaggtgtg cgccccggag
    10741 ctgcgcgagc tggcggccgc gtcgcggccc gtggccgccg ccgtggactc gcccggccag
    10801 cgccgcgcca ggatcgccga agccgccgcc gccgtggcgg accggctcgg catcgacccg
    10861 cccgccgatc cggcgcacga gcacgacgtc agcaccggcc gtccggcgcc gccaccgctg
    10921 cccgcgggcg tgctcgccga cctggacgcg gtccggcgct ggctcgccgt gttcgactgg
    10981 aaggtgcccg tccgggtggg ggtcggcgcg ttctgccgcg aacgtttcgg ctcagggtcc
    11041 cgcacgccct tcctggaggc gtgccgggcg gcgacggcgg cgctgccgca cctgttcggc
    11101 cccgccgcga tgccgtggtt cctcgacctg accggtgacg gtcgcctgcg tgagctggac
    11161 cgtctccgga cgcgcgcccg cgatctcgcc cgctccggcg tcctcgaccg gcggcgggtg
    11221 ctggctgaca cggccgactg gcccgcctgg ctgacctggc ccgcctccac tggtttctac
    11281 ctgcagaccc tgcccggtgg ggtggtgctg aacgcggtgc atgccgggca cggccgcgcg
    11341 gcgggtcgcg tccaccacct cctcgcccgg gcgggcgccg cgccgccgcg cccgccccgc
    11401 tccggcctgc cgcgtgccga gttcggcggc aggttcggct ccgcgctcaa cacccgcacg
    11461 ccgagcacgc ggtacgagat cgaccacccc ggcgcgacgt ccggccgcga cccccggcac
    11521 cgtgtcccgc tcggcacgct catggtggtg cacgacccgg acaccgacct ggtccacctg
    11581 cacagcgacc ggctcggccg cgtcgaaccg gtgcacctcg gcatgatggg cgagctgggg
    11641 ctgcccgccg tggccggttt cctcgaacgc gccttcgcgc ccacctacct gttccacccg
    11701 agcgtgccgc cgttcatctc gctgcgtgac ctggccggcg cctcctcggc gcggcgcttc
    11761 cccagggtga gtgtcggcga cgtggtcgtg cagcgcgccc gctggacggt gcccgccggc
    11821 ctggtgcccg cgcgtaccgg ggcggacggt gaccacctgc tcgcgctggc cgagtggcgg
    11881 cgcgagcacg gcatccccga gcggtgtttc gtgcgcggct ggaagccggg cgcagcgctg
    11941 ggcaaggcgc gcaagccgct ctacgtcgac ttcgcctcct ggcatctggt cgccctgttc
    12001 gaacgggagg cgcgaaccaa cgccgccctg gtcatcgacg aggccctgcc ggacccgctg
    12061 gccgacggcg cccccgcgca cgtcaccgag taccacgtcg agatcggcga ccgggagaga
    12121 gagcaatgac cgaacggccc ggctggttcg cggcgcatgt gcactaccgc ggcgacctcg
    12181 acgcgctgct gcgcgaagcg gtcgcgccgc tggtgcgcgc gcttgccgcc gacttcttct
    12241 tcctgcgcta ctgggacggg ggcagccacc tgcggctgcg gctgcgcggc ggggaccagg
    12301 tcgcggtcgc ccggcacctg gacgcctacc ttgccgccca ccccgcgccg gagaccacct
    12361 cccaggagga gtacgcccgc gtcgccccgg tgctggccgc ccgcgagggc atgacgggcc
    12421 acctgacgac gctgcggccg aacaacaccg tggagttcgc ggcgtaccgg ccggagaccg
    12481 cgaagtacgg caccggcgac gcgctacgcg ccgtcgagcg gcatttcgtc gagtccagcc
    12541 ggtacgcgct tgacgtcctt gaccgccgcc cgaccggcaa ccaacgcgag ctcgcagtgc
    12601 tcggcgtcct gctgctcgcc tggtacgccg cccgcccact cgatgagccg cctggtgagc
    12661 cggtcgatga cgagctgatc ggcgcggtcg aggcgctgtg ccggggctgg cgcggcggcc
    12721 gggacctgcc cgaggagctc gtggcggagg agtacggccg ggtgcgggag cgtgtggccg
    12781 ggctggccgg cgcgctgcgt gacctcgttc cggacccgga cgcgcccggc agcagcatgc
    12841 gcgcgtgggc ggcgacgttc gaccggctcg ccgccgcgct gcccccgccc gaccggctgc
    12901 gggtgctcga cacgtgcgcg catctggcgg ccaaccggct gggcgtgtcc atggcggccg
    12961 aggtgcggct gcggctgctc gccgcgcggg ccctgcgcga ggtcgcgccc gtggggaggc
    13021 gatgatgagc tggcgacgcg tcgacgtggc ctaccacgat cccgaccttg acgggctgat
    13081 cctggccacc cggccgctgc tggccgggac gcccggccgc ggctggttcc agcggcactg
    13141 ggtccgcggt ccgcacctgg agctgtggtt cgacgccgcg cagccgtcgt gggagcggat
    13201 ccgcgacgtg ctggagccct ggctgcgcgt caacccgtcg cgcgcccgga tcgaccgaga
    13261 ccggctgctg gcgcagcacc ggcacctcgc cgccgccgaa cggatcgacg agccgctgct
    13321 gccgttctac gccgacaaca cgctgcaccg ggccgctccg cgctcccgcg cacacgtgct
    13381 cggtggtccg gcggccgagg agctgttcca cgacttccac accaccgcca gcgccgtggc
    13441 ttacgacgag ctcgacgccg tgcgggcggg agagtcgcgg ctggtgatgg cactggacct
    13501 gatggtcgcc gccgcgcacg cgcacgccga gggcggcgtc cgcggcgggt tcgtgtcgtt
    13561 ccgctcgcac gcggaggcgt tcctggcgag cgcgcccggc ctgcgcgagc gctgggacgc
    13621 cgagtacgcc gcccgggcgg gggcgctgcg agcgcggatc accgcggtgg tcgccggaat
    13681 cccgcgcggc cgggcgtggg ccgggctgct cgaccggttc gcggaccgcg gcgacgagct
    13741 gatcgcctcc ggcgcgctgc tggtcgagcc cgccgggccg gacgcggtcg cccggcccga
    13801 caccgccttc caccgggcgc tgcgcggcaa ccggacctgg cacgaggagg tgctgcgctc
    13861 agcaccgttc cgccgctacc ggctgctgct gaacctgacc tacctgcagc tttcccggct
    13921 cggggtgaac gccgtgcagc gggcgctgct gtgccacttc gccgcgtcgg cggtcgagca
    13981 ggagtacggg gtgtccgcca tcgagatcgc catgggaggc gcgtgatgtc agtacaggtc
    14041 gagcccgcag tgacgcaccg gtgggcactg cggcccggcg tctaccgggc caccgcgcca
    14101 ggcggcgatc tcatgctcgc cgcctggccg cacgccacgc cgctcggccg ggccaccccc
    14161 gagctgctgg ccctgctgga cggcctggcc gccggatcgc tgccgctcga cgagcccggc
    14221 gacctcgcgc ccgccgtcga gctgctgcgc gcgggtggct ggctgcgcaa gacggtggcg
    14281 tacgcgggac gcgacctcta caccatcacc cccgtcgccg cccccaccga cgcgccgcca
    14341 ccgccgcggg acgaaccggc gctgtcgcgg ttcgcgctgc tgcgcaacac cgcggacggg
    14401 ctggtgctgg agatgcccgg ctcctggtgc gacgtccacg tgcacgaccc ggcggtggcc
    14461 gcgctgctcg ccgacccgtc cggcgacggc ggcctgcccg ccgaggccgc ggccgcgctg
    14521 cgcgccgacc tggccgccgc cggcatgctg atggagcggg aggagccgtt cgagcggcgg
    14581 cagtggagca cccacgagct gtggttccat gaacgcagcc ggctcggcaa ccggggctgg
    14641 ttcggcgcgc acttcggcgg cacgttctgg gcccgcggcc ggcacgaccc gccgcccgcg
    14701 cggccgtccc cctaccccgg cccggccgtc gagctggccc ggccggacct cgcggcgctg
    14761 cggcgcaccg accccacgct caccgccgtg ctggaggacc gcgaaagcgt ccgcgaccac
    14821 gacgacgacg atccgatcag cgctgagcag ctcggcgagc tgctctaccg gtgcgcgcgg
    14881 gtgcggctgc tgcgtcacct ggaaggcttc gagtacgccg gcaagccgta ccccgccggt
    14941 ggctcggcgt acgagctaga ggtgtacccg gtcgtgcggc tggcccgcgg cctcgacccc
    15001 ggcatgtacc actacgacgc gcacgaccat cggctgcgcc aggtccggcc cgccggccac
    15061 ccggcggtgc gcaggatgct gaaggtcgcc acggagtcgt ccgtcgccaa ggcgccgccc
    15121 caggtgctgc tggtgatcag cgcgagagtc ggccggatcc tgtggaagta cgaggcgatg
    15181 gggtacgcgc tcatgctgaa gcacgtcggc gtgctgcaac agacgctgta cgcggtcgcc
    15241 accgccatgg acctggcccc gtgcgcgctc ggcagcgggg acgatctcgc cttcaccgcc
    15301 gccaccggcc gggaccggct ggtggagtgc gcggtcggcg agttcatggt cggcagcagg
    15361 cggaaggagc ccgcggcatg ggagctctga acctcctcct gcgccccgac gcgcactacg
    15421 ccgaggtcga cggcggcgtc tacgtgctga gccaccaggg cgagaccttc atctcgggca
    15481 cctcggtgca ccggtggctc gaccgcctcg cgccgctgct cgacggcacc cgcacgctcg
    15541 accagctcac cgccggcctg cccgccgacc gggccggctt cgtggccaga cttgtcggca
    15601 cgctcaccga acgcggcctg gtgcgcgagg tcggcccggc ggtgtcggac acgctcaccg
    15661 acgccgaacg cggcgagcac cgtgccctgc tggcctacct gggctacttc cacgactcgc
    15721 ccggccgcgt cctcgaggac gtgcgcgaca ccccgaccgc gatcgtgggg tccggtccgc
    15781 tggccgccgc ggtggtccgc gcctgcgccg ccgccgggct gcgccgggtg gagatcggcg
    15841 aggaggcggg cgcggcccgg gtggtcgtcc acgtggccga gcgcgccgag cccgaacggg
    15901 cggcgcggct ggaacggcgg tgcgccgccg agggggtgct gctcgcacag gtcatgccgg
    15961 ggccggacgg catctggtgg cagcccgcgg cccgcggcgg ctgctgggcg agcgcgtggc
    16021 gccgccaccg ggcgctcgcg ggcgtggatc ggacgggcac gccgctcgat ccggtggcgg
    16081 tcgcggtggt ggccggccag gtggcacacg acgtcttccg cgtcctcgcc ggactgcgcg
    16141 aggaggcgcc gccccggttg gtggtgctcg atccgcggac gctggcgagc accgcgcacc
    16201 cggtggtggc gcacccgttc gagctgcccg ccgcgccgct ggacgaggcg gcgttcctcg
    16261 accgggtcgc cgcgctgcgg gcagcgcccg cgctgagcga ggcggagttc tcccggcggg
    16321 ccaaggggct catggactcg acagtggggc tgttcgccga gatcgacgag ggcgacctcg
    16381 cgcagttgcc gctgcacgtc acggcgacca cggtggccga cccgtgcggg ctgatcggct
    16441 ccgcgccgcg gcccgtggtc accggcgcgg ggctcacgtt cgaggaggcc cgctaccgcg
    16501 cggcgcgcgc cgcgctcgcc ctggccggca ctctcgcgct cgaccggcgg aggctggtcg
    16561 acggccgggt gtgggcgtac gaccttgcgg acggggccgc ccggctggtt ccggccgacg
    16621 aggtcttcgc aagcacggcg ggcgggagca cggcgggcgt gccgctcggc gcggcggcag
    16681 cctactcgtg ggccgaggcg gtcgcggagg gcctggtcgc gcaggccgcc gcgctcactc
    16741 tcgccggcgc cgggcacgcg ggcgagccgt atggacgggc ggacctcgcc ggggcgcctg
    16801 cgtatctcct cgccatggtg cgggcgctcg gcgaggagct gaccgtgcac gacgtcaccg
    16861 ggccgctggg cgtgccggtc gtggtgggga cgctgtccgg cggggcgacc gcctgcggcg
    16921 cgggcatgac cacggacgcc gccgtcaccg cgtgcctgcg cgacctgctg ctgctgcgcc
    16981 aggccgagat caacgaccag cccgtctacg ccccaccatc cggcaggccc ttgcccgggc
    17041 atctacgcgg gaaccacccg gcgcccgccg tgcccggcac ggacgccgac cggctggcgg
    17101 cccgcctggc cgagcggggg caccgccctc tggcggtgcc gctggatcat gaccaggccg
    17161 tgcacgcggt cctgcccttc gccgtccggg tggtgtgccg atgatccgcc tgcccgacca
    17221 cggcgagctt gccgtgccga tcggcgacgg gccgatgctg ccgctgcgca ccgaactcgg
    17281 ccgggtggtc atcggcccgc tggagcggcc cggcgtgccc ggatgccggg cctgcgtgcg
    17341 catccgcgcg gcgcgggtcc agcccgacgc ccgcaaggcc gaggccgtac gcgcccggca
    17401 cgcccccgcg cccagccagt ggctcacccc gctcgccacc gacctggtgc gcgtcctggt
    17461 cgcgagcgag agcgctgccc tggcagccga caccgacccc cgcaccgcgg gtgccgtgct
    17521 ggagatcgac ctcgccacgc tggaaatcac caggcaccgg ttcctgcccg acccgctctg
    17581 cccgcactgc ggcggtctgc cgccggacgg cccggccgag ctgaccctgc ggccccgccg
    17641 caagctcggc ggcagtcccc ggaccaggcc ggtcgagctg aacgcgctgc tggagacgta
    17701 cgtggacggc cgggtcggga tgatccggcc gctgaagtcg ggcgtgcagg gcggactgac
    17761 ggtggccagc gccatgctgc cgatccgcgc gggccacggc ctggaaccgg gggtcggccg
    17821 tacccgcagc tacaccgcga gcaggctggt cgccgtgctg gaggcgctgg agcgctatgg
    17881 cggcgtcagc cccggcggcc gccgcaccag cgttaccgcc gcctaccgcg acatctccgg
    17941 ccacgccgtc catcccgaca ccttcggcac acaccccgag gagaactacg acaggcccgg
    18001 cttcgccttc cggcgcttca ccgaggacac cgtgtgccgg tgggtgtggg gctactcctt
    18061 cgccaaggcc cagcccgtgc tggtgccgga gaaccaggtc tactactacg ccagaaacct
    18121 gccggacggc gagcagccgt tcgtcttcga ggtctccaac ggctgcgcgc tcggctcgtg
    18181 cctggaggag gcgatcctgc acggcctgct cgaggtggtc gagcgggacg cgttcctgct
    18241 cacctggcac gcccggcggg aggttccggt gctgaacccc gcgctggcga gcgacccggt
    18301 cctgcccatg caggccgccg cgatcaccgc cgagaccggg caccgggtgc tgtgcttcga
    18361 caccaccgcc gagcacggca tccccagcgt gtgggcgatg gccgtggacg tcgaacaccg
    18421 gtcggaccgg cccgccaccg cccacgccgc cggcgcggcg ctcacgctgg agcaggccgc
    18481 catgaacgcg ctgagcgagc tcggcccgct gctggccgac gtgatccgcc gctaccccga
    18541 ggagcgggaa cgggccgagg ccatggtccg cgaccccgag caggtcgcca ccatgcacga
    18601 ccactccctg ctctacgcgg ttcccgccgc ggccgaacgg ctgtcgttcc tcaccggccg
    18661 cgccgacggc ccgcggaccg gcttcggctc ggcccggttc accggcgacg acctcaccgc
    18721 cgatctgcgg gccatgatcg acgcggtgat cgacgccggg atggacgtgg tggtcgtcga
    18781 ccagaccacg ccggagcacc tggcgggcgg gttccgctgc gtgaaggtgc tggtgcccgg
    18841 cgcgctgccg atgacgttcg gccaccagta ccggcggctg gacaacctgc cgcggctggc
    18901 ggccgcgcgt accaccgacc cgcacccgtt cccatgagcg ggcgcccgga cagcggaaag
    18961 gagccgtcgt gtacgtggtg atcgtcgcgt tcgacctgaa ggagtcctcc gtcgacttcg
    19021 ccgaactgcg cgcctgggtg cgggaccggg cggcggacga ctactcccgg ctgccgggga
    19081 tgcgcttcaa gacgtggttc tccgacgagc gaaaacggct ctggggcgcg gtgtacctgg
    19141 tggagtcgat gttgtcgttc gaccgggaca acctcccgct gctgcccgac ggcaggaccg
    19201 ggccggtcgg cacccggccg acgtcggtca tggtgctgga gttggaggcg ttcgtcaccg
    19261 ggccggacgg cctggacggg atcgaggcgc tcgcccggca agggctgagc atgacgggag
    19321 gcggccatga ccactgaggc gacgactgcg gtgaccactc gtgcgaacgc cggagcgctg
    19381 tccctgccgg cgcgtggcac ggaccggccg ctgctgctct acgtcaacat cccgttctgc
    19441 aactccaaat gccacttctg cgactgggtg gtggacgtgc ccgtctccga cctgcggctc
    19501 gcccccgcgg cgccgcgccg ggtcgactac ctggccgcgc tgtgcaccca gatccgcacg
    19561 cacgcccccg ccttgcgggc cgccggttac cgcggtgagg tcatgtactg gggcggcggc
    19621 accgccaccg tcctcaccgc ggcggagatc gagcaggtcc acgcctgcct cgcggccgag
    19681 ttcgacctga cggcgctggc cgaggcgacg atcgagggca gccccgagtc ggtggacccg
    19741 gccaagctga ggctgctgcg ggacctcggc ttcgaccggg tgagtctcgg cgtgcagtcg
    19801 ttcgacgaga ccaggctgcg ccgcatcggc cgcgcccact ccgcgggcca ggccgtgcgc
    19861 agcgtcgagg acgcgcacgc ggcgggcttc gacaacatca acatcgacct gatcgtgggc
    19921 ttccccgacc agtcgctcgc cgaggtggag cagaccgtgc ggcgcgccct cgacctgccg
    19981 gtcaaccact tctcggttta ctcctaccga gcgaccgagg gcacggtgat gcgcaggcag
    20041 atcgaacgca gcggcacggc catcgagctg gagcatcagc tccagtcgta ccggctggcg
    20101 ggcgagatgc tcgcggcggc gggacatccc gagtacgccg tctcctactt cggtgcgccg
    20161 cgctgcctcg ccgacgaggc gtactaccgg ctcagcatgg actggatcgg cttcggcacg
    20221 ggcgccaact cgctgatcaa ccagcgctac ctgctcaacg gccgcggccg gatgcgtgac
    20281 ttcaccagca ggccgggcga gttcgaggtg gacctgccgg ccggagtgcc gtcactcacc
    20341 gtgcagtggc tgcccagggc gctgggcacc gccgagggca tcgacgcggc gaccttccag
    20401 cgtcgcaccg gcacgtccct gcgtgcggcc tgcgaggaac ccgagctgaa cgcgttcctc
    20461 acccgggtga acgagttcgg ccggctcgtc gtggaccgcg acggcatccg cctggccgac
    20521 gagaaccgct cggacgtgct gtcgcgcacg ttcgccgcga tgggctgggt gtcctgacgt
    20581 ggaggcgatg cgcacgctgc tcgcggccgc cgacctggtc acgccgatgg cgctgcgggt
    20641 gtcggcgacg ctgcggctcg ccgaccacct ggccgccggc acgaccggcg ccgccgagct
    20701 cgccgcggcc gccggggtcg acgaggcggc gttgacacgg ctgctgcgct acctggtcgc
    20761 gcgcggcgtc ttcaccgagc ccgcgcccgg tgagttcggc ctcaaccccg ccgccgaact
    20821 gctgcgcgac ggccgccccg accggctgcg cgactggctc gacctcaccg ggccgatcgg
    20881 ccgcgccgac ctggcgttcg ggtcgctgct ggacgtcgta cgcaccggca agcccggtta
    20941 cccgatgatc cacggccggg gcttctggga cgacctcgcc gccgagccgg cgctcgccac
    21001 cgcgtacgac accctgatgg gcggcaagcg ccagtgggcc gcgaccacgc tcgccgccct
    21061 ggactggagc cgctcccggc acgtcgtgga tgtcggcgga ggcaacggca cgctgctgtc
    21121 gtgcctgctg gccgcgcacc cgcacctgcg cggcaccgtc gtggaccggc ccacctccgc
    21181 gaaggccgcc ggagcagtac tggcctcggc cggggtggcg gaccgtggcg agtttcgcgc
    21241 gggcgacttc ttcgagccgc tgccggtgca cggcgccgac acatacctgc tcagctcgat
    21301 cctgcacgac tgggacgacg ccgcggctac ggcgatcctg cgccgctgcg cggaggccgc
    21361 cgcgccgggc gggcgggtgc tgctctgcga gctggtggcc atggccgggc cggaccggcg
    21421 gacggtgacg cacatggatc tgtgcatgct cgtgtacttc ggcggccggg agcgcaccgc
    21481 cgccgacttc gccgcgctgg ccggggcggc cgggctggag ccgcgctcgg tgacgccgct
    21541 cccgccccac gactggggca acgccctcgt ggagtacgcg gtccccgccg cccgctgacc
    21601 ggaaaagacc cctgccgacg gcgacggtca gcgcggcgcg gctccgttga tcgcgcccgc
    21661 ctgggccgca cgatgagctg gagcgctggt cccactcgac cgcaatcgcc gtggaggtgt
    21721 gggcacttcc cggcgagccc tgtccggcga cgtcgcggag ctcgtccatg ccacgatccc
    21781 cgacgtactc gacggctcgg gacgggacgg atcggtgcgg tgcgcgggca tcgcgctcac
    21841 cgcgggcgcc cgcgggctgc gcctgaccac cagccacgac ggctccggct cgccgcgctg
    21901 gggttcaaac tcactaccca gggccggtac gggatgagtt tcgtccgctt ctgtgaggaa
    21961 cgcggcgctg accgggtggc ggcgcgccgg ttcggcctac atcaaggagc tgatgcccga
    22021 catctggatg gcaccatcga gccggggcaa atgttcgacg ccacgaccga tgcgatgtcc
    22081 cgcgaccggc cgtcgcggtg aggcgtgccg atgcatcacg acgagctcgg aataccgagt
    22141 ctgcgtcggg gtggatttgt ggctggtcga tgagtttggg atgctgcgca ggtctgcctg
    22201 ccgataccac ctgactggaa ggggatcacc gcgatggcga aggtcatctc tacgttgttc
    22261 atctctgctg acggtgtggc cgagatcgac cccgattggc acttcccgta cttcgacgag
    22321 aacatgggcc gcgccgtcgg cgaggactat gacaccgctg acgtgctgtt gatcggtcgc
    22381 gagaccttcg acagcttcgc cggagcgtgg cccgaccgcg aggcggcggg tggggacgac
    22441 gcaccgttcg ccaagcaact cggggacatg cgcaaggtgg tcgtctcccg ccagccgctg
    22501 gagttctcct ggcgcaactg cgaactgatc acgggcgatc tcctcgatgc cgtcacctcg
    22561 ctcaaggccg atgccggcat caggggcatc ctcatccccg gttcgatctc cgtggtgcag
    22621 cagttgctcg ccgcagggct ggtcgacgag ttgcgcctgc tggtgcaccc ggtggcggcg
    22681 cgtaagggcc gcaggctgtt cgacgacggc gacgcgccgt accacctgag cgtgacggcg
    22741 acggagacgt ttccgacggg cgtgatccgc gtgatctact cgccgaccga ggcacccacc
    22801 aaagtcggct acgacgaggt cgaggcccag gtgtccaccg gggaatag
//
