BGC0000604: GE2270A biosynthetic gene cluster from Nonomuraea sp. WU8817
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Location: 1 - 22,848 nt. (total: 22,848 nt).
This entry is originally from NCBI GenBank FJ461359.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000604
Short description GE2270A biosynthetic gene cluster from Nonomuraea sp. WU8817
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
FJ461359.1
via Knock-out studies
Compounds
  • GE2270A
Species Nonomuraea sp. WU8817 [taxonomy]
References
Chemical products information
GE2270A Evidence:
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C56H55N15O10S6
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACS83759.1
  • tpdR
 1 - 714 (+) TetR transcriptional regulator
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    • ACS83760.1
    • tpdO
    		 711 - 2612 (+) cyclodehydratase
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      • ACS83761.1
      • tpdP
      		 2609 - 5098 (+) dehydratase
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        • ACS83762.1
        • tpdQ
        		 5095 - 6129 (+) cytochrome P450 monooxygenase
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          • ACS83763.1
          • tpdS
          		 6218 - 6904 (+) hypothetical protein
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            • ACS83764.1
            • tpdT
            		 6947 - 8065 (+) N-methyl transferase
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              • ACS83765.1
              • tpdU
              		 8094 - 9338 (+) coproporphyrinogen III oxidase
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                • ACS83766.1
                • tpdA
                		 9462 - 9635 (+) GE2270 prepropeptide
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                  • ACS83767.1
                  • tpdB
                  		 9646 - 12129 (+) dehydratase
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                    • ACS83768.1
                    • tpdC
                    		 12126 - 13025 (+) dehydratase
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                      • ACS83769.1
                      • tpdD
                      		 13025 - 14026 (+) hypothetical protein
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                        • ACS83770.1
                        • tpdE
                        		 14023 - 15390 (+) dehydrogenase
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                          • ACS83771.1
                          • tpdF
                          		 15378 - 17204 (+) hypothetical protein
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                            • ACS83772.1
                            • tpdG
                            		 17201 - 18937 (+) cyclodehydratase
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                              • ACS83773.1
                              • tpdK
                              		 18969 - 19337 (+) hypothetical protein
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                                • ACS83774.1
                                • tpdL
                                		 19327 - 20577 (+) coproporphyrinogen III oxidase
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                                  • ACS83775.1
                                  • tpdM
                                  		 20579 - 21598 (+) O-methyl transferase
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                                    • ACS83776.1
                                    • tpdN
                                    		 22234 - 22848 (+) deaminase reductase
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                                      Biosynthesis information
                                      Annotation changelog

                                      Entry version: 3

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-10-07
                                      Update chemical activity to schema version 2.11
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 2

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2019-10-16
                                      Migrated from v1.4
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 1

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2015-06-12
                                      Submitted
                                      • (ID: O4PIO7VEX2IICIP2RGFFKN3C)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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