Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000604.1:
Cluster 1RiPP122848

BGC0000604, GE2270 biosynthetic gene cluster from Nonomuraea sp. WU8817. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: GE2270A
SMILES string: Copy to clipboard
Molecular formula: C56H55N15O10S6
Molecular activity: Antibacterial
Molecular target: EF-Tu

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
Thiopeptide (cyclic)
Peptides in this cluster:
ACS83766.1
RiPP core peptide sequence(s): SCNCVCGFCCSCSP
Leader peptide length: 41
Follower peptide length: 2
Peptidase(s) involved in precursor cleavage:

Gene cluster description

GE2270 (BGC0000604). Gene Cluster 1. Biosynthetic class = RiPP. GenBank FJ461359. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Detailed annotation

tpdA leader / core peptide, putative Class I
MSELESKLNLSDLPMDVFEMADSGMEVE - DhaLDhbAGHGMPEVGADhaCNCVCGFCCDhaCDhaPDhaA

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Esther Schmitt (Novartis Institutes for BioMedical Research)

Literature references

1. Morris RP et al. (2009) Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu. J Am Chem Soc 131(16):5946-55. doi: 10.1021/ja900488a.