LOCUS       BGC0000605             17179 bp    DNA     linear   BCT 25-JUL-2016
DEFINITION  Streptomyces sp. ATCC 55365 GE37468 gene cluster, complete sequence.
ACCESSION   BGC0000605
VERSION     BGC0000605
KEYWORDS    .
SOURCE      Streptomyces sp. ATCC 55365
  ORGANISM  Streptomyces sp. ATCC 55365
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 20:00:31
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17179
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..174
                     /gene="getA"
     CDS             1..174
                     /codon_start=1
                     /gene="getA"
                     /gene_functions="biosynthetic-additional (thiopeptides)
                     predicted thiopeptide"
                     /gene_kind="biosynthetic-additional"
                     /product="GE37468 structural preprotein"
                     /protein_id="AEM00614.1"
                     /transl_table=11
                     /translation="MGNNEEYFIDVNDLSIDVFDVVEQGGAVTALTADHGMPEVGASTN
                     CFCYICCSCSSN"
     CDS_motif       1..126
                     /prepeptide="leader"
                     /note="peptide class: thiopeptide"
                     /note="predicted sequence:
                     MGNNEEYFIDVNDLSIDVFDVVEQGGAVTALTADHGMPEVGA"
                     /locus_tag="getA_thiopeptide"
                     /aSTool="thiopeptides"
                     /tool="antismash"
     CDS_motif       127..171
                     /prepeptide="core"
                     /locus_tag="getA_thiopeptide"
                     /peptide="thiopeptide"
                     /predicted_class="Type III"
                     /score="25.90"
                     /molecular_weight="1520.8"
                     /monoisotopic_mass="1519.5"
                     /core_sequence="STNCFCYICCSCSS"
                     /aSTool="thiopeptides"
                     /tool="antismash"
                     /leader_sequence="MGNNEEYFIDVNDLSIDVFDVVEQGGAVTALTADHGMPEVG
                     A"
                     /leader_location="[0:126](+)"
                     /tail_sequence="N"
                     /tail_location="[171:174](+)"
                     /alternative_weights="1538.8"
                     /alternative_weights="1556.8"
                     /alternative_weights="1574.8"
                     /alternative_weights="1592.8"
                     /alternative_weights="1610.9"
     CDS_motif       172..174
                     /locus_tag="getA_thiopeptide"
                     /note="tail peptide"
                     /note="thiopeptide"
                     /prepeptide="tail"
                     /aSTool="thiopeptides"
                     /tool="antismash"
     misc_feature    1..17179
                     /note="GE37468 gene cluster"
     protocluster    1..17179
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[7136:11985]"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7137..11985
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
     protocluster    1..17179
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2942:11985]"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /neighbourhood="10000"
                     /product="thiopeptide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      2943..11985
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /neighbourhood="10000"
                     /product="thiopeptide"
                     /protocluster_number="2"
     cand_cluster    1..17179
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /detection_rules="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /kind="chemical_hybrid"
                     /product="thiopeptide"
                     /product="LAP"
                     /protoclusters="2"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..17179
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000605"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..17179
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="thiopeptide"
                     /product="LAP"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and ((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or PF07366 or PF06968 or PF04055) or thiostrepton)"
                     /rules="((((goadsporin_like or PF00881 or TIGR03605) and
                     (YcaO or TIGR03604)) or TIGR03882 or TIGR03603 or
                     TIGR03602) and not cyanobactin_synth)"
                     /subregion_numbers="1"
                     /tool="antismash"
     mat_peptide     127..168
                     /gene="getA"
                     /product="GE37468 antibiotic protein"
     gene            335..1297
                     /gene="getB"
     CDS             335..1297
                     /codon_start=1
                     /gene="getB"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 191.8; E-value:
                     2.4e-58)"
                     /gene_kind="transport"
                     /note="putative host resistance"
                     /product="ABC transport associated protein"
                     /protein_id="AEM00615.1"
                     /transl_table=11
                     /translation="MISASGLAKSYTVRRGRERLQVDAVSDASFEVAEGEIVSFLGPNG
                     AGKTTTLRMLTTLASPNSGSAQVAGHDVVAQPREVRRRIGYVSQGGSAGGFARVGDEIV
                     DRAMLYGLDAATATRRARALLERLDLADSWTRVPRSLSGGQRRRLDVVMGLVHQPRLLF
                     LDEPTAGLDPQARANLWGHIRDLREEYGMTVFLTTHYLDEADVLSDRVIVFDHGRVVTT
                     DTPDALKDRISGDLIEMEVAGPEQVDAAVRILEKSAADQPKVTGLRMAGRVHRSGTVLP
                     GLARELDAAGVELVSLEVRRPTLDDVFLTLTGRSLRDSH"
     misc_feature    392..394
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1319..2065
                     /gene="getC"
     CDS             1319..2065
                     /codon_start=1
                     /gene="getC"
                     /gene_functions="transport (smcogs) SMCOG1065:ABC-2 type
                     transporter (Score: 138.8; E-value: 2.8e-42)"
                     /gene_kind="transport"
                     /note="putative host resistance"
                     /product="ABC type II transporter protein"
                     /protein_id="AEM00616.1"
                     /transl_table=11
                     /translation="MLHDTMVVFRRQMRMTLRSPAMVLTGLLQPVLYLVLFAPLLRSVA
                     AQVGSANQYTLFVPGLLVQLAVFGAAFTGYGVIGEWRDGVIEGERVTPAPRAALLLGRL
                     GRDLVQLLVQVVVLIALAYAFGMDAPLPELFVGVVITLLLGVACAATSNAIALSAKDER
                     VMGSVVNTLLMPVILLSGILLPVGLGPHWLRVTAGLMPVKHVVDAVRSCFAGDLSTSGV
                     LWGSGWALLLCLLGVWFGTRTFRAEA"
     misc_feature    1400..1402
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2943..5087
                     /gene="getD"
     CDS             2943..5087
                     /codon_start=1
                     /gene="getD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_N"
                     /gene_kind="biosynthetic"
                     /product="lantibiotic-type dehydratase"
                     /protein_id="AEM00617.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 7.7e-15, bitscore:
                     43.7, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDDAAAAFHTWSGARDRLRDLDAQLGDALAAAERDDVEHLRGLC
                     LDPRFLTGLRATSRDLADTARRWATGQTGAPQRKRLLRLTRMAARAGAKTSPFSSWMVT
                     VPARWGRPGGAVTGERLLAELDGAVVGVLTRALQATLPDAADLEVRVNPSLVPVEGGWL
                     FIRAGQREQAVRAAAHPAIDELLRALAPGDTEASLAARVPGGTGLVSKCLTAGLIEHCL
                     PVADHHPRPWAAWAAIAAERGVTELSAGLSALDTALHAAEAPVAQAAAGQVAHHLGVEL
                     PPVEVHEMSVATGWPYDLPARPDGTALAELDCARRLLALTDVKFPAKLAAAEHLAKRFG
                     ADYDVPLTVALDSLARARLDADDDVCRIIGPAAPPWGADLARCSGGLVRELGAALPRLT
                     EDVLTLAAKGPLAVADVRRLLDDFPFTHPNRSATFYLQETSEAAIRRVVNVVHGGHGRG
                     RGRLAARAGIPVTDLVTTVDEDIVEIGGLLGSALNSRAATAPRELQYPGATTDRPREQR
                     LPMASVRVVPGAHGLPALRDEDGRDVCLVHLGMAADLALPAFVRLLEQVFGSACLIHPS
                     IAVFTPGAPGRTGAPQSATPRVTLGATVLQRARWLLRREEFPGGGEPRGSLRAWHQWLT
                     AHGLGSRFYLRAWSSADHGRGQSKARKPVFIDVTSPLLFADAEKMLRQAEFAIVEECLP
                     DPLAGTGHVTEYAVEVGVRR"
     misc_feature    2997..2999
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    3495..3497
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5015..5971
                     /gene="getE"
     CDS             5015..5971
                     /codon_start=1
                     /gene="getE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /product="lantibiotic-type dehydratase"
                     /protein_id="AEM00618.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.5e-41, bitscore:
                     131.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPARPPGRDGPCDRVRGRGGSATVTTWASWHVHQHHDQDRLLVEA
                     VAPLIRAVRADGLADRAFVLRYWDGGPHVRLRLRAPSDAALAQLEARVPAELLDWCRQH
                     PSERTMGAEEYALLRNRIGDPASAAELIPDGSVVRAAYVPEHQRYGRGAALAACEEHFD
                     HSTRIALDVLAAGPADSARDSLVVLVLARFLMARGSRVGLGWARRVQELGVPAAARLDL
                     TRITALLERPPSPVERITRSLERLEAGLRMAGDDYRPPTVGFGGVTFEATEAQDPITTL
                     DICIHLFANRIGVTMPTELTLRACLAQALVAATKADA"
     gene            6301..7050
                     /gene="getF"
     CDS             6301..7050
                     /codon_start=1
                     /gene="getF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /note="similar to TclM"
                     /product="putative aza-diels-alderase protein"
                     /protein_id="AEM00619.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.3e-18, bitscore:
                     56.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADRAGVELRQDWLADNSLTWTTGALAATGTAETTLQSLLEDFHY
                     AATVPALRLLSAAPGERLGLACADLMAVTAQEFGRGGLVSAALSFRSHAEAYLNLEAAP
                     DERAAWDAAARASAPALRRRLLAVATGPDRPAYARDWLGLITPLVRAAEQAQRRGELAL
                     PTLAEGFSSDLTERSAFHRGLAGSTSWEDVRTSDWFVLYRFAINLLYLQLSRLGVKPVG
                     RYRLCHLVATALDQREAPTTTAEEGDS"
     gene            7137..8411
                     /gene="getG"
     CDS             7137..8411
                     /codon_start=1
                     /gene="getG"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_kind="biosynthetic"
                     /note="similar to microcin B17 McbC"
                     /product="dehydrogenase"
                     /protein_id="AEM00620.1"
                     /sec_met_domain="PF00881 (E-value: 6.4e-09, bitscore: 25.9,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAWPHHLSLPTGRRTAEVIARLADGGQPAGADDDVTEALRREGWL
                     YEEFSDDRGVAFAVRPLRARGPVPAAEGRLDLSRFAVIRVEAGALMMESPLASAEITIH
                     RRELLTAALDPAADSATATGGLAAALREQLLGTGFLADPHGDETQELRYRQWSPHELMF
                     HDRSRLGYRGYVGDGFGGTWWGRAAGFEPEPAAPPPYRGPRVPLAVPDFTDRRTSEGSY
                     FEVTERRRSERVHDDESPISVDQLGELLYRTARVRRVHEEDGVEFVSSPRPSGGSVYEL
                     ELYPLVTRCSGLDSGMYHYDAHRHELELVRPVSDYSVRRMLRVASQGSTTGAVPQVLLV
                     VAARVGRVMWKYEGMGYAVVLKNTGVLYHALAGTCGAMGLAGCPLGTDDAVAFTEATGR
                     DPLVECSVGQFIVGSVPRRRGEQSR"
     gene            8408..10051
                     /gene="getH"
     CDS             8408..10051
                     /codon_start=1
                     /gene="getH"
                     /product="GetH"
                     /protein_id="AEM00621.1"
                     /transl_table=11
                     /translation="MSTIRRVNAYTIDHEGRTYGLSESGPLELSTGLSAWIRLVSSWVD
                     QGQDIEQAADDLGGAHAGQARRVRDAMMSVGVLRRFDAPGEVRFVGERTDLIRAVERSA
                     PALPDVVLGAGPLYDDWFDEVRAEAGAGRAGVVLFTEGAAVVAGPMAAEQLEEVVTALR
                     CGDLADGRPGPDVIRTAAAQLVRRAALGSGDEWSGVMITREETSSWRALPHPWRPAPPG
                     PAAGPFDERVMAAIDPVHGVVREIGEDDLPQVPRHLARARVAGRATVRPLDLDVVADGS
                     DYAQARRRAVLAAVALYLESTLDPRAVVDAEGKRVVGDTADLSVLRAATDRIAADPGRW
                     FLPARRVVDDSRLLVPVDRVRRCDESAGPSLGTAAAETRDDALATALLDVLEAWAVGAT
                     SMLVRIRDGEALPAEVREALDQLRLSDREAWLGVLPDGDVPTAVATTRHGTAYACGTSH
                     AAAAVRAMEQAVLADQVLMHDRADLLPQTWAPPVPRAARAVDLSVAAPITLADLRRAVA
                     LRAPDAAVAELDHDAGIVRLGISAVKVVVD"
     gene            10051..11985
                     /gene="getI"
     CDS             10051..11985
                     /codon_start=1
                     /gene="getI"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     TIGR03604"
                     /gene_kind="biosynthetic"
                     /note="similar to cyanobactin YcaO"
                     /product="cyclodehydratase"
                     /protein_id="AEM00626.1"
                     /sec_met_domain="TIGR03604 (E-value: 7.3e-108, bitscore:
                     350.4, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 6.2e-75, bitscore: 242.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGTLTNTDREQAVQSGLLASSLSGAPALLGVEVRASDSWSLPAD
                     GPVDRPWLSVHTEVGQVIVGPLTRPGVAGCPHCLDLRRQRVDASRPWLARLREEHGARL
                     ERDVPQLLDQLAAGVVADAAAALVADETAAGRPAGQPEVREPVGQDEPRLVAVIDLATL
                     ETRRHRFLPDPFCPHCGALPEDSADRAQRVLRPAAKITPFGSRTRDVLADFDTIRELYV
                     DPFSGLIRRTDRGAEGGLVMSGASMPLRFDNLAEPGYGRSRDYRTSELTAILEALERYG
                     GVAPGGLQTSVRGTFHELAPHAVHPDVFGRHPDESYDDPSFRYRRFDPDRPLWWVWAHS
                     FATGNARLVPEALAYYYCHRLRGDDPVSYYEVSNGCALGSSWEEATLHGLMETVERDAF
                     LCTWYTRTVPPTIDLGSCHDPRVPLQAGAIGSSTGYRIHAFDITTDYGIPAVWVMAAHP
                     DRKGPALLCTAGAGLDPERALLNALNELGPILSDVIRRYPAEEERAAQMVRDPYGVVTM
                     PDHSALYAHPEAAHRLDFLFDGPTIGIDEVGGPDRLRPDRDDLTVDLRAAVERVGEVLV
                     VDQTTPEHRAGGLTCVKVLVPGAVPMTFGYRNRRIDGLPRLLSLPRRLGRLDAGLTRAQ
                     LNPDPHPFP"
     gene            12105..13133
                     /gene="getJ"
     CDS             12105..13133
                     /codon_start=1
                     /gene="getJ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 299; E-value: 8.2e-91)"
                     /gene_kind="biosynthetic-additional"
                     /product="P450 monooxygenase"
                     /protein_id="AEM00625.1"
                     /sec_met_domain="p450 (E-value: 9.9e-19, bitscore: 57.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHHVFRAEDVRTVLSDSGTFSSDRTRMMPPTAQLGRGNLTMMDPP
                     DHTRMRRIVNQAFTPASVRGLAPAIDEIAGELVRGLAPERFDLVRDLAYPLPIRVISRF
                     LGLPEEEHGRFREWSVGFSRGDAAQMDAMHRYLAEVATAKRARPVRDLMSRLATAEVDG
                     APATIDEIASLSGLILLAGHVTTTSLIAAAVRELCVRPALDAQVREHDRIDDLVMEALR
                     SRPAFAQVTRIAAGEATLSGVTVPAGALVSAWILSANHDPGLNPDPERFLLDRPARRHL
                     SFGHGVHYCLGGPLAQLEAVTAVRAVAGRFARLTVLAPVEFHPLPTLSIRRLVLAGQAY
                     GS"
     gene            13303..15063
                     /gene="getK"
     CDS             13303..15063
                     /codon_start=1
                     /gene="getK"
                     /note="similar to microcin B17 McbC"
                     /product="dehydrogenase"
                     /protein_id="AEM00624.1"
                     /transl_table=11
                     /translation="MPESGRPMVRRGLDHLERCGALRREVVARPEDIPGQLLAVADLFS
                     EAPYGRCAALLAARATVCAPVDWLQPLDAALRQLSVRAEPPTSPGSCGVLVRIGEVEVA
                     LAPDDGWLVEPIGQVERSVAAAAVAAEAVARFLGRPARPLPGARRLPGLDRRGPRTSTG
                     APLLDPWPAPEQLRELLLDPASLLPAGELKCPRPAAVRPLAAGEGPRMPDWLRALLWCV
                     HVPLRWESGDLAHSGGWAHRGLASARGFYPVELYLVTDTGAWYVEPGDLRLVPVSPSAS
                     SDPGSRFTLVLTVRETKVSHRYDRYATRLCLQEAGLALAALGDAAREAGIAADAVAELG
                     ERGRSGPWGELLDLGPDERPVGRIMLGPPQRALDARSFARHLALVRQRRSGHRVFDALG
                     AERVGRLGSLPAELTAALDDRLSTFLVVHRPCLDAAAGRWEPGCYRVTGHGPEPVRAGL
                     EPTEQLQRGQDAMGWLAPDYLSASATVIVAVPVDEATADVRRLHDITAAAARIAHRGLL
                     GAAAAGAVGRIHNSLRADVVAAVTGEKQLAPLFQLIVGCAGPDGTITVDVAEAAFIGNG
                     ITKLTGDTRC"
     gene            15177..15836
                     /gene="getL"
     CDS             15177..15836
                     /codon_start=1
                     /gene="getL"
                     /note="similar to TetR"
                     /product="transcriptional regulator"
                     /protein_id="AEM00623.1"
                     /transl_table=11
                     /translation="MAELVLRIGYPKISVQDVAEHAGIGKGTVYKHWNSKEDIIDDVLV
                     REFEHVHAQFLALLPGDRRIATLHGTSGVLYRLVMANPVLRAYNTRDGRVLGTHVAAQG
                     KADALGISLVSVLARLPYLELLRDNGLLIEAVCSPEGQLSIEAVISGFVARAGHADDPE
                     QTKASSRMMATVLRRAFEPVDPPQPADHDRMTEAMLSARPLRSATPMRATPTTGER"
     gene            15833..17179
                     /gene="getM"
     CDS             15833..17179
                     /codon_start=1
                     /gene="getM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1244:amidohydrolase (Score: 284.4; E-value: 2e-86)"
                     /gene_kind="biosynthetic-additional"
                     /product="aminohydrolase/peptidase"
                     /protein_id="AEM00622.1"
                     /transl_table=11
                     /translation="MTLRLPDWAPDLYQILHRSPELGFQEHRTAGLLAEVLGREGFTLT
                     RGIGGTGLVAVLDRGPGPVVAARAELDALPLQERTGSDFASTVDGVMHACGHDLHLVAL
                     AGAAAQVASRPDLPPGRIVLILQPAEELGSGAARMVEDGLTEVVPHPDLLLSQHVSAMA
                     PVGVLVSTPGTALAAADTITVTARAPGGHTGSPDSGPDPVLFAACLTQRLHTVVGRDLP
                     PFEQAVVSVPGIAAPSAPGLRAPRATLTVNIRTFEERVRKTVLGRVDALVRAEAAAAGL
                     AFGDDVRLIHETHVPRVENNAPVRDRLTAVHRSRLSMGHLTVPPALASDDVSLLVRAFG
                     CAAVYWFVGSGEPGGRLGPVRPACHTDEYLPHPATLAVATAAMREALLAGLAGELCEPR
                     RAAQPDPAAQTEAEKASPQNSSCGPRLSSTRTSWEYGQCPRGDLNPHAR"
ORIGIN
        1 atggggaaca acgaggagta cttcatcgac gtcaacgacc tgtcgatcga cgtgttcgac
       61 gtcgtggaac agggcggtgc cgtcaccgcg ctgaccgccg atcacggcat gcccgaggtc
      121 ggtgcgtcga ccaactgctt ctgctacatc tgctgctcct gcagctccaa ctgacgccac
      181 gtcagttgat gggaggaatt ccccgcttcg gtgaatccgc ccaaggctga acaagtccgg
      241 tcccgcggcc tgccctctgg cgccgcggga ctgtggcgta cctctcgtcc cttcgcggcc
      301 cgcggcggga cctgtgaaca agcgaggtag gaacatgatt tcagcgtccg ggctggccaa
      361 gtcctatacc gttcggcgtg gtcgcgaacg gttacaggtc gatgcggtct cggacgcgag
      421 cttcgaggtc gccgagggag agatcgtctc cttcctcggg cccaacggcg cggggaagac
      481 cacgacgctt cggatgctca ccaccctggc cagtccgaac tccggatccg cgcaggtggc
      541 cggccacgat gtcgtcgccc agccgcggga ggtacgccgg cggatcggct atgtctcgca
      601 gggcggatcg gcaggcggat tcgccagggt cggtgacgag atagtcgacc gcgccatgct
      661 gtacggcctc gacgcggcca ccgccacgcg aagggcccgc gcgctgctcg agcggctgga
      721 cctcgccgac tcctggaccc gcgtcccgcg atcgctgtcc ggcgggcagc gccgacggct
      781 ggacgtggtc atgggcctgg tgcaccagcc gcgactgctg ttcctcgacg agccgaccgc
      841 cggtctcgac ccccaggcgc gtgccaatct gtggggccac atcagggatc tgcgcgagga
      901 gtacggcatg accgtcttcc tcacgacgca ctacctcgac gaagccgatg tactcagcga
      961 ccgggtgatc gtgttcgatc acggacgggt cgtcacgacc gacaccccgg acgcgttgaa
     1021 ggaccggatc tccggcgacc tgatcgagat ggaagtcgcc ggaccggaac aggtggacgc
     1081 cgccgtgcgc atcctggaga aatccgccgc ggaccagccc aaggtgaccg ggctgcgcat
     1141 ggccggccgg gtgcaccggt ccgggaccgt ccttcccgga ctcgcccgcg aactcgatgc
     1201 ggccggggtg gaactggtgt cgctcgaggt gcgccgcccg accctggacg acgtgttcct
     1261 caccctgacc ggacgctccc tgcgggactc gcactgaacg ccgagaaagg cctcatccat
     1321 gctccatgac acgatggtcg tgttccggcg tcagatgcgc atgacgctgc gcagcccggc
     1381 catggtcctc accgggctgt tacagccggt gctctacctg gtgctgttcg ccccgctgct
     1441 gcggtcggtc gccgcccagg tcggttccgc gaaccagtac acgctcttcg tgcccggtct
     1501 cctcgtccaa ctggccgtgt tcggggccgc gttcacgggt tacggagtga tcggcgagtg
     1561 gcgtgacggt gtgatcgagg gcgaacgggt cacccccgcg ccacgcgccg ccctgctgct
     1621 cggccggctc ggccgggacc tcgtccaact gctggtccag gtcgtcgtgc tgatcgctct
     1681 cgcgtacgcc ttcgggatgg acgccccgct gcccgagctc ttcgtgggcg tggtgatcac
     1741 gctccttctc ggggtggcct gtgccgcgac gtcgaacgcc atcgccctga gtgccaagga
     1801 cgagcgcgtc atgggcagcg tggtcaacac cctgctcatg ccggtcatcc tgctctccgg
     1861 gatcctgctg ccggtcgggc tgggaccgca ctggctgcgt gtcacggcag ggctgatgcc
     1921 ggtcaagcat gtcgtcgacg cggtccggtc ctgcttcgcc ggtgacctgt cgaccagcgg
     1981 tgtgctgtgg ggcagcggct gggccctgct gctgtgcctg ctgggtgtgt ggttcggcac
     2041 cagaacgttc cgcgcggagg cctgacgggt cgtagcgcgg ctgacggata ccggcccttt
     2101 tcggtgtgct cgggccggtg ttcgtcgtgc cgtcgaaggg atcgttctcc gacgccccac
     2161 cttgcccaca gcagccgtga cttcgcaggt cagcgccttg ttggtgaggt cttgacgcgc
     2221 cagggaaatc cgccgcgtgg tgtccttgcc tacgggaccg gaggatcact agagtcgaag
     2281 gcgctgaagg attatcagac tttatggtga tcgtttgcgc tgtggtgcca gggggactcg
     2341 cacagcgcca ttggaagcgt ttcgctcgcc ggcgcggaag ccgcagaccg ggcgggctcg
     2401 gatctcaatc acacagtgag cccctgcgcg ggcggtgttt tgatcccgtg gtcgagagcg
     2461 catcgggcca ggtgccatcg gctgggtggg ggcgtgagtt cgagtatggg ggtgcttgac
     2521 gacgtgtacg caaaagccgg aacgcggcgg taaccagccg gccgcacggc ccaactgacg
     2581 gtcgatcgca caagtacggc ccggttccgg ggcaagccac gggggtaaac agggtggatc
     2641 ctgttgatga ctgttcgatc ttctctcaag acatcgcggt ggacgaggtc gttctcgtcc
     2701 gggtggcggg actgagccgg tctgcgctca gcgggttcca tcatcaccgc atcgacgacc
     2761 tgctgtccga tcaggccaga gcgaccacgg agctcgccga gtccgccgaa cgagccgacg
     2821 cggccctgtt ccaggacatc ggcgcacaca caggtgagga gcgggccgcg ctgatcgccg
     2881 cgcgccgcgg agtgcgccag ggagacctgt cccggcggac cgcgcagcag gccgtgccgg
     2941 tgatgcgcga cgacgccgcg gccgcattcc acacctggtc gggtgcgcgg gaccggttac
     3001 gcgacctgga cgcgcagttg ggcgacgccc tcgcggcagc cgaacgcgac gacgtggagc
     3061 acctgcgcgg actgtgtctc gacccacggt tcctcaccgg actgcgggcg acgagccgag
     3121 acctggctga caccgcccgc cgctgggcca ccgggcagac cggcgccccg cagcgcaagc
     3181 gactcctccg gctcactcgc atggcggccc gcgccggcgc gaagaccagc ccgttcagtt
     3241 cctggatggt cacggtcccg gcccgctggg gtcgccccgg cggcgcggtc accggagagc
     3301 ggctgctcgc cgaactcgac ggtgcggtgg tcggcgtact cacccgggcc ctgcaggcca
     3361 ccctgccgga cgccgcagac ctggaggtgc gggtcaatcc gagccttgtc ccggtcgagg
     3421 gcggctggct gttcatccgg gccggacagc gggaacaggc agtccgggcg gctgcgcacc
     3481 cggcgatcga cgagttactg cgtgccctgg cacccgggga caccgaagcg agcctcgccg
     3541 ctcgggtgcc cggagggacc ggcctggtga gcaagtgcct gaccgccgga ctgatcgaac
     3601 actgtcttcc cgtcgcggac catcacccgc gcccgtgggc cgcatgggcc gcgatcgccg
     3661 ccgagcgagg cgtgacggag ctgtccgccg ggctctccgc gctcgacacg gcgctgcacg
     3721 ccgcggaagc gcccgtggcg caggccgctg ccgggcaggt ggcgcaccac ctcggggtcg
     3781 agctgccgcc ggtcgaggtg catgagatgt cggtcgcgac cggctggccg tacgacctgc
     3841 ccgcccgccc cgacggcacg gcgctcgccg aactcgactg cgcccggcgg ctgctggcgc
     3901 tgacggacgt gaagttcccc gcgaaactcg cggctgccga gcacctggcg aagcgtttcg
     3961 gcgcggacta cgacgtacca ctgaccgtgg cccttgacag cctcgcccgg gcgcgcctgg
     4021 acgccgacga cgatgtctgc cggatcatcg ggccggcggc accgccgtgg ggagccgacc
     4081 tggcacgctg ctccggcggc ctggtacggg agttgggcgc ggcgctgccc cggctcactg
     4141 aggacgtgct gaccctggcc gcgaagggcc cgctcgccgt ggccgatgta cgacggctgc
     4201 tcgacgactt ccctttcacc cacccgaacc gttcggccac gttctacctg caggagacct
     4261 ccgaggccgc gatccgcagg gtggtgaatg tcgtacacgg cgggcacggc cgtggccggg
     4321 gtcgtctcgc cgcccgggcg ggcatccccg tcacggacct ggtcaccacc gtcgacgagg
     4381 acatcgtcga gatcggcgga ctgctggggt cggcactgaa ctcgagggcg gccacggcgc
     4441 cacgggagtt gcagtatccc ggtgccacga ccgaccggcc gcgcgagcag cgcctgccga
     4501 tggcgtcggt gcgtgtcgtg cccggtgcgc acggcctgcc cgcactccgg gacgaggacg
     4561 gccgggacgt gtgcctggtg cacctgggca tggccgcgga cctggcactg cccgcgttcg
     4621 tcaggctgct ggagcaggtc ttcggaagcg cctgtctgat ccacccgagc atcgcggtgt
     4681 tcacccccgg agcacccggg cgcaccgggg cgccgcagtc ggccacccca cgcgtgacgc
     4741 tcggagccac cgtgctgcag cgggcgcggt ggctgctgcg acgggaggag ttccccggcg
     4801 ggggcgagcc gcgcggatcg ctgcgtgcct ggcaccagtg gctcacggcg cacggtctgg
     4861 gcagccgctt ctacctccgg gcgtggagct ccgccgacca cggccggggc cagagcaagg
     4921 cgcgcaagcc ggtgttcatc gacgtcacca gcccgctgct gttcgccgac gccgagaaga
     4981 tgcttcggca ggccgagttc gccatcgtcg aggaatgcct gcccgacccc ctggccggga
     5041 cgggccatgt gaccgagtac gcggtcgagg tgggagtgcg acggtgacga cctgggcgtc
     5101 ttggcatgtg caccagcacc acgatcagga tcggctgctg gtcgaggcgg tggctccgct
     5161 gatccgggcg gtccgtgccg acgggctcgc cgaccgggcg ttcgtcctgc ggtactggga
     5221 cggcggcccg cacgtgcggt tgaggctgcg cgcgccgtcc gacgcggccc tggcccaact
     5281 ggaggcacgg gtaccggccg aactgctgga ctggtgccgg cagcatccgt ccgagcggac
     5341 catgggcgcc gaggagtacg cgctgctgcg caaccggatc ggcgaccctg cctcggccgc
     5401 cgaactgatc cccgacggct ccgtcgtacg ggccgcctac gtcccggagc accagcggta
     5461 cggcagggga gcggcgttgg cggcatgcga ggagcacttc gaccacagca cgcggatcgc
     5521 tctggacgtg ctcgccgcag gccccgcgga ctccgcccgg gactcgctgg ttgtgctcgt
     5581 cctggcccgc ttcctcatgg cacgcggcag ccgggtcggc ctcggctggg cccgccgcgt
     5641 ccaggagttg ggcgtcccgg ccgcagcacg gctggacctg acccggatca cggccctgct
     5701 ggagcggccc ccgtcgccgg tcgagcgcat cacccgctcc ctcgaacggc tcgaggccgg
     5761 gctgcgcatg gcaggggacg actaccgccc gccgaccgtc gggttcggcg gtgtgacgtt
     5821 cgaggcgacc gaggcacagg acccgatcac gacgctggac atctgcattc atctcttcgc
     5881 gaaccggata ggagtcacca tgcccacaga gctgacgctg cgcgcctgtc tcgcgcaggc
     5941 actggtcgcc gcgaccaagg cggacgcgtg accggggcgc aggagcaggc cgtgacactc
     6001 gtcggccctg aggtcacgga ctgtcaggga ttgttcgcat accacgcgga ggaccgctgg
     6061 gatgctctgc tgctggggcc ggtccgggag tgtgcccggc tggcggagga atccggctgt
     6121 cggttccggg tgacccgcga gtggcagcgg ggaccgcacc tgcgcctcgg ggtgcgtggt
     6181 cccgccgaag cgacggccac ggtgcgcaag cagatcgacg aggtcctgca cgaggtcctg
     6241 cgctccagcc cgtcgacccg gaccgtgaca ctcgcagcgg tccgggaacg ggcgcagcag
     6301 atggccgacc gcgccggggt cgagctgcgc caggactggc tcgcggacaa ctcgctcacc
     6361 tggacgaccg gagccctcgc cgcaaccggc actgcggaaa cgaccctgca gagcctgctg
     6421 gaggacttcc actacgcggc gaccgtgccg gcgctgcggc tgctgagtgc ggctcccggc
     6481 gagcggctcg gcctggcctg cgccgacctg atggcggtga cggcccagga gttcggccga
     6541 ggtggtctgg tctcggcggc gctgtccttc cgctcgcacg ccgaggcgta cctgaacctg
     6601 gaggccgcgc cggacgagcg cgcggcctgg gacgccgccg cccgcgcatc ggcacccgcg
     6661 ctgcgccgcc gactgctcgc ggtggcgacc ggcccggaca ggcccgccta tgcccgggac
     6721 tggctcgggt tgatcacccc gctggtccgg gccgcggagc aggcccagcg acggggcgaa
     6781 ctcgccctgc ccaccctcgc cgagggcttc agctccgatc tgaccgagcg cagtgccttc
     6841 caccgtggac tggccggctc cacctcctgg gaggacgtgc gcacctccga ctggttcgtg
     6901 ctctaccgct tcgcgatcaa cctgctctat ctccagctgt cccggctcgg cgtcaaaccg
     6961 gtcggacggt accgactgtg ccacctggtg gccacggccc tggaccaacg ggaagctccg
     7021 acgacgactg ccgaggaggg cgactcgtga cccgagcgca ggacatcgcc gcgggccgga
     7081 ccgaacgact gaggtcggga gtgttcagtg ccgagcgcga cgggcgtacc cacctcatgg
     7141 cctggccgca ccatctcagc ctgcccaccg gccgccggac ggccgaggtc atcgcccggc
     7201 tggccgacgg cgggcagccg gccggcgcgg acgacgacgt caccgaggcg ctgcggcgcg
     7261 aaggctggct ctacgaggag ttcagcgacg atcgtggtgt cgcgttcgcg gtgcgtccgc
     7321 tgcgcgcccg cggaccggta cccgctgccg aggggcggct cgacctttcc cgattcgcgg
     7381 tcatccgggt cgaggccggc gcgctgatga tggaatcacc cctggccagt gccgagatca
     7441 cgatccatcg gcgggagctg ctgaccgccg ccctcgaccc cgcggccgac tcggcgaccg
     7501 cgaccggcgg gcttgcggcc gcgctgcgcg agcaactgct cggcaccggt ttcctggccg
     7561 acccgcacgg cgacgagaca caggagctgc gctaccgcca gtggtcaccc cacgaattga
     7621 tgttccacga ccgcagccga ctcggctacc gcggatacgt cggcgacggg ttcggcggta
     7681 cgtggtgggg tcgcgcggcg ggtttcgagc ccgagcccgc cgccccgcct ccctaccgtg
     7741 ggccgcgagt ccccctcgcc gtaccggact tcacggatcg ccgtacgagc gagggctcct
     7801 atttcgaggt caccgagcgg cgccggtccg agcgggtgca tgacgacgag tccccgatct
     7861 cggtggacca actcggcgaa ctgctgtacc gcaccgcccg ggtgcgccgc gtgcacgagg
     7921 aggacggcgt ggagttcgtc agctctccgc gcccttccgg cggatcggtg tacgagctcg
     7981 agctgtaccc cttggtcacc cggtgctcgg gcctggacag cggcatgtac cactacgacg
     8041 cgcaccggca cgagctggag ctggtgcggc cggtgagcga ctactcggtg cgccggatgc
     8101 tgcgggtcgc ctcccagggc tcgaccaccg gcgccgtccc gcaggtgctg ctggtcgtgg
     8161 cggcccgggt cggccgggtg atgtggaagt acgaggggat gggctatgcg gtggtgctga
     8221 agaacacggg ggtcctctac cacgccctcg ccggcacgtg cggcgccatg ggactggccg
     8281 gctgccccct gggcacggac gacgcggtcg ccttcaccga ggccaccggc cgcgatccgc
     8341 tggtcgagtg cagcgtgggc cagttcatcg tgggatccgt cccgcggcgg cgcggggagc
     8401 agagccgatg agcacgatcc ggcgtgtgaa cgcctacacc atcgatcacg agggcaggac
     8461 ctacggcctg tccgagtcgg ggccgctgga gctgtcgacc gggctgtccg cctggatccg
     8521 tctggtgtcc tcctgggtcg atcagggcca ggacatcgaa caggccgcgg acgacctggg
     8581 cggcgcgcac gccggacagg cccgtcgggt acgggacgcg atgatgtccg tgggagtcct
     8641 gcggcgattc gacgcccctg gtgaggtcag gttcgtcggc gagcgcacgg acctgatccg
     8701 cgcggtggag cgcagcgcgc cggccctgcc ggacgtcgtc ctgggtgccg gccccctgta
     8761 cgacgactgg ttcgatgagg tccgggccga ggccggagcg ggccgggcgg gcgtcgtgct
     8821 cttcaccgaa ggcgccgccg tggtcgccgg gccgatggcc gccgagcagc tcgaagaggt
     8881 cgtgacggca ctgcgctgcg gtgatctcgc cgacgggcgg cccggcccgg acgtgatccg
     8941 gacggctgcc gcgcagctgg tccgtcgtgc cgccctcgga tccggtgacg agtggagcgg
     9001 cgtcatgatc acccgggagg agacctcttc ctggcgggcg ctgccgcacc cgtggcggcc
     9061 ggctcccccg ggcccggctg ccgggccgtt cgacgaacgg gtgatggcgg cgatcgaccc
     9121 ggtccacggc gtcgtgcgcg agatcggcga ggacgacctc ccccaagtgc cccggcacct
     9181 ggcgcgggcc cgggtcgccg gacgggccac cgtccggccg ctggacctgg acgtcgtggc
     9241 ggacggctcg gactacgccc aggcccggcg ccgggccgtg ctggccgccg tcgcgctgta
     9301 cctggagtcg accctcgacc cgcgcgcggt ggtcgacgcc gaagggaaac gcgtcgtcgg
     9361 cgacaccgcc gacctgagcg tgctgcgcgc cgcgacggac cgcatcgccg ccgaccccgg
     9421 acgctggttc ctgcccgccc gccgagtggt cgacgacagc cggttgctgg tccccgtcga
     9481 ccgggtgcgg cgctgtgacg agagcgccgg gccgtccttg ggcaccgccg cggccgagac
     9541 acgggacgac gcgctcgcga cggcgctgct cgacgtactg gaggcctggg cggtgggggc
     9601 gacgagcatg ctcgtgcgca tacgtgacgg agaagcgctc cctgccgaag tgcgcgaagc
     9661 tctcgaccag ttgcggctga gtgatcgcga agcctggctc ggcgtactgc cggacggcga
     9721 cgtcccgacc gccgtggcga ccaccaggca cggcaccgcc tacgcctgcg gcaccagcca
     9781 cgccgccgca gcggtccgcg cgatggagca ggccgtgctc gccgaccagg tgctgatgca
     9841 cgaccgcgcg gacctcctac cgcagacctg ggctccgccg gtccctaggg cggcccgggc
     9901 cgtcgacctg tccgtcgcgg cgccgatcac gctcgcggac ctgcgccgcg ccgtggcgct
     9961 gcgcgcgccg gacgcggccg tggccgaact cgaccacgat gccggcatcg tccggctcgg
    10021 aatatcggca gtgaaagtgg tggtggactg atgacgggga cgctgacgaa caccgaccgt
    10081 gaacaggccg tgcagtccgg gctgttggcg agcagcctgt ccggcgcacc ggcgctcctg
    10141 ggcgtcgagg tgcgggcgag cgacagctgg agcctcccgg cggacgggcc ggtcgaccgc
    10201 ccctggctga gcgtccatac ggaggtcggt caggtgatcg tcgggccgct gacccggccg
    10261 ggcgtggcgg gctgcccaca ctgcctcgac ctccggcggc agcgtgtcga cgcgagcagg
    10321 ccctggcttg cccggctgcg tgaggagcac ggagcccgac tggagcgcga cgtgccgcag
    10381 ttgctcgacc aactcgccgc cggggtggtg gcggacgcgg ccgctgcact ggtggcggac
    10441 gagacggccg ccggccggcc ggcaggacag cccgaggtgc gggagccggt cggccaggac
    10501 gagccgcgac tggtggcggt gatcgatctg gccaccctcg aaacgcgccg ccaccgtttc
    10561 ttgcccgatc ccttctgccc gcactgcgga gcactgcccg aggactcggc ggaccgggcc
    10621 cagcgcgtcc tgcggcccgc tgcgaagatc acaccgttcg ggtcccgcac ccgcgacgtc
    10681 ctggccgact tcgacaccat ccgcgagctg tacgtggatc cgttcagcgg cctgatccga
    10741 cgcaccgacc gcggcgccga gggcgggttg gtgatgtcgg gcgcatcgat gccgctgcgg
    10801 ttcgacaacc tcgccgagcc cggttacggc cggagccgtg actaccggac cagcgagctg
    10861 accgcgatcc tcgaagccct ggagcgctac ggcggcgtgg ctccgggggg tctgcagacc
    10921 tccgtgcgcg gcacattcca cgaactcgcg ccacacgccg tgcaccccga tgtgttcggc
    10981 cgccaccccg acgagagcta cgacgacccc tccttccgct atcgcaggtt cgacccggac
    11041 cggccgctgt ggtgggtgtg ggcacactcg ttcgccaccg gaaacgcccg cctggtgccc
    11101 gaggcgctgg cgtactacta ctgccaccgc ctgcgcggcg acgatccggt ctcctactac
    11161 gaggtgtcca acggctgtgc cctcggctcg tcctgggagg aggcgacgct gcacgggctg
    11221 atggagacgg tcgagcgtga cgccttcctg tgcacgtggt acacccggac cgtcccgccg
    11281 acgatcgacc tgggctcctg ccacgacccg cgcgttcccc tccaggcggg cgcgatcggc
    11341 tcgagcaccg gctaccgcat ccacgccttc gacatcacga cggactacgg gatcccggcg
    11401 gtctgggtga tggccgcgca tccggaccgg aagggccccg cgctgctgtg caccgcgggg
    11461 gccggcctgg atccggagcg ggccctgctg aacgcgttga acgagctcgg tccgatcctc
    11521 agcgacgtga tccggcgcta tccggccgaa gaggagcgag ccgcgcagat ggtgcgcgat
    11581 ccgtacggcg tcgtcaccat gccggaccac tccgcgctct acgcacatcc ggaggccgcg
    11641 caccggctcg acttcctgtt cgacggcccg accatcggca tcgacgaggt cggcgggccg
    11701 gaccggctgc gcccggaccg cgacgacctc acggtggacc tgcgggccgc ggtcgagcgc
    11761 gtcggcgagg tgctcgtggt cgaccagacc acgcccgaac accgggccgg cggcctcacc
    11821 tgtgtcaagg tcctcgtccc cggggcggtg ccgatgacct tcggctaccg caaccggcgc
    11881 atcgacgggc tgccgcggct gctgagcctg ccgcgacggc tcggcagact cgacgcgggc
    11941 ctgacccggg cgcagttgaa ccccgacccc catccgttcc cgtgagggcg gcgccgacgg
    12001 ccggattccc ggccctgacc gaactggacg gcgccgggtg gaccggactg ctgcgctggc
    12061 tcgccgacgc gcggcgagag accccggtcc tcgaactcgc cggcatgcac catgtgttcc
    12121 gcgcggagga cgtgcgcacc gtgctgtcgg acagcgggac gttctcctcc gaccggaccc
    12181 ggatgatgcc gcccaccgcg cagctcgggc gggggaacct gaccatgatg gacccgcccg
    12241 accacacccg gatgcggcgg atcgtcaacc aggcgtttac gcccgcctcg gtccgcggcc
    12301 tcgcgcccgc gatcgacgag atcgccgggg aactcgtacg cggcctcgca ccggagcggt
    12361 tcgacctcgt gcgcgacctc gcctatccgc tgccgatccg ggtcatctcc cggttcctcg
    12421 gtctgcccga agaggaacac ggccggttcc gtgaatggtc ggtcgggttc agccgaggtg
    12481 acgccgccca gatggacgcg atgcaccggt acctggccga ggtggccacc gccaagcggg
    12541 cacggccggt gcgggacctg atgtcacgcc tggcgaccgc cgaggtggac ggggcgccgg
    12601 cgacgatcga cgagatcgcc tcgctgagcg gcctgatcct gctggccggc catgtcacca
    12661 ccacctcgct gatcgccgcg gcggtccgcg aactgtgcgt ccgaccggcg ctcgacgcac
    12721 aggtccggga acacgaccgg atcgatgacc tggtcatgga agcgctgcgc agccggcccg
    12781 ccttcgccca ggtgaccagg atcgcggcag gggaggccac cctgtccggc gtcaccgtac
    12841 cggccggtgc cctggtgtcg gcgtggatcc tgagcgcgaa ccacgacccg gggctgaacc
    12901 cggacccgga acgcttcctg ctggaccgtc cggcccgccg gcacctgtcc ttcgggcacg
    12961 gtgtccacta ctgcctcggc ggccccttgg cccagttgga ggcggtcacc gcggtgcgcg
    13021 cggtcgcggg ccggttcgcc cggctgaccg tgctggcgcc ggtggagttc cacccgctgc
    13081 ccaccctctc catccggcgc ctcgtgctcg cagggcaggc ctatggctcc tgacctgtac
    13141 ccgcgactgc tcagcggggt gcacgcggtc gcgggccgga acagcacgct gctgaccacg
    13201 ccgaccggcc accaccgcgg ccaggccgga ctccatccgc tgctgcaccg ccttgcccct
    13261 ctcctggacg gccggacggc cgagtcctcg gtcctggccc ggatgccgga gtccgggcgt
    13321 ccgatggtcc ggcgcggcct ggaccacctg gagcgctgtg gcgcgctgcg cagagaggtc
    13381 gtcgcgcgcc ccgaggacat tcccggtcaa ctcctcgccg tcgccgacct gttcagtgag
    13441 gcgccgtacg ggcgatgcgc ggcgctgctc gccgccaggg ccaccgtgtg tgcgccggtg
    13501 gactggctgc agccgctgga cgcggctcta cgccagctct cggtacgcgc cgagccgccc
    13561 acctcgcccg gttcctgcgg ggtcctggtg cggatcggcg aggtggaggt ggcgttggcg
    13621 ccggacgacg gttggctcgt ggagccgatc ggccaggtcg agcggtccgt ggccgccgcg
    13681 gctgtcgcgg cggaggccgt ggcccggttc ctcggccgcc cggcccgccc gctgcccggc
    13741 gcgcgccggc tgcccggcct cgaccggcgc ggcccgcgaa cgagcaccgg cgcaccgctg
    13801 ctcgacccgt ggccggcgcc ggaacagctg cgggagcttc tgctcgatcc ggcctcgctg
    13861 ctgcccgcag gggagctgaa gtgcccgcgg cctgccgcgg tccggcccct cgcggcgggc
    13921 gaagggccgc gcatgcccga ctggctccgc gccctgttgt ggtgtgtgca cgtgccgctg
    13981 cgctgggagt cgggcgacct cgcgcactcc ggcggctggg cacaccgcgg gcttgcctcg
    14041 gcgcgggggt tctacccggt cgagctctac ctggtgacgg acaccggcgc ctggtacgtg
    14101 gagccagggg acctgcggct ggtcccggtc tccccgtccg cgtcgtccga tccggggtcc
    14161 cggttcactc tggtgctgac cgtgcgcgag accaaggtct cccaccggta cgaccggtac
    14221 gcgacccggc tgtgcctgca ggaggcgggc ctggctctcg cggcgctggg cgacgcggca
    14281 cgagaggcgg gcatcgcggc cgacgcggtc gccgagctgg gtgagcgggg ccggagcggc
    14341 ccctggggcg agctgctgga cctggggccg gacgagcggc cggttgggcg gatcatgctc
    14401 ggcccgccgc agcgggcgct cgatgcgcgg tcgttcgccc ggcatcttgc gctggtccgg
    14461 cagcggcgct ccgggcatcg ggtgttcgac gccctgggag ccgagcgggt cggtcggctg
    14521 gggtcgctgc ccgccgagct gaccgccgcc ctcgacgacc ggctcagcac gttcctggtc
    14581 gtccaccggc cctgcctcga cgccgcggcc ggccgctggg aaccagggtg ttaccgggtg
    14641 accggacatg gcccggaacc ggtccgggcg ggcctggagc ccacggagca actgcagcgc
    14701 gggcaggacg cgatgggctg gctcgccccg gactacctca gcgcctcggc gacggtgatc
    14761 gttgccgtac cggtcgacga ggccactgcg gatgtgcgac ggctgcacga catcaccgcg
    14821 gcggccgcgc ggatcgcgca ccggggcctg ctcggcgcgg cggcggcagg ggccgtgggg
    14881 cggatccaca acagcctgcg cgccgacgtg gtggccgcag tgaccgggga gaagcagctc
    14941 gccccgctct tccagctgat cgtcggctgc gcgggccctg acgggacgat caccgtcgac
    15001 gtggccgagg cagcgttcat cggtaacgga atcacgaaac tcacggggga tacacgatgt
    15061 tgatcactct gcgacaggcc gcgttccagc cgcacggcaa cgccacggcc ggaccgttcc
    15121 ggtccgggca ggcgaaaggc gatcgatgta gccgttccgc ccgagtcctc gacgccatgg
    15181 ccgaactcgt cctgcgcatc ggctacccga aaatcagcgt ccaggacgtc gccgagcacg
    15241 cggggatcgg caagggaacc gtctacaagc actggaacag caaggaagac atcatcgacg
    15301 acgtcctggt gcgcgaattc gagcacgtgc acgcacagtt cctggcgctc ctgcccggag
    15361 accgcaggat cgccaccctg catggcacga gtggtgtgct gtaccgcctg gtcatggcga
    15421 atccggtcct gcgggcctac aacacacgtg acgggcgtgt gctcggcacc catgtggcgg
    15481 cacaggggaa agcggacgcc ctcgggatct cccttgtctc ggtcctggcg cgccttccgt
    15541 atctcgaact gttgcgggac aacggtctgc tcatcgaagc ggtctgctcc ccggagggcc
    15601 aactgtccat cgaggccgtc atcagcggat tcgtcgcccg tgcgggccac gcggacgacc
    15661 cggagcagac gaaggcgtcc tcccgcatga tggcgaccgt gttgcgccgg gcgttcgaac
    15721 ccgtcgaccc gccacagccg gcggatcacg accggatgac cgaggccatg ctgtcggccc
    15781 gcccactgcg gtccgccacc cctatgcggg cgacccccac gacgggtgag cgatgaccct
    15841 tcggctgccg gactgggccc cggacctcta ccagatcctg caccgcagtc ccgagctcgg
    15901 attccaggag caccgcacag ccgggctcct ggccgaggtg ctcggccgcg agggcttcac
    15961 cttgacccgc gggatagggg ggaccggcct tgtggcggtg ctcgaccgcg gcccaggacc
    16021 cgtcgtcgcg gcgcgcgcgg agcttgatgc cctgccgttg caggagcgca ccggctcgga
    16081 cttcgccagc acggtggacg gcgtgatgca tgcctgcggg cacgacctgc atctggtggc
    16141 gctcgcagga gcggccgcac aggtggcgtc ccggccggac ctgccgccag ggcggatcgt
    16201 cctcatcctg cagcccgcgg aggaactcgg cagcggcgcc gccagaatgg tcgaggacgg
    16261 tctgacggaa gtcgtcccac accccgacct gctgctcagc cagcatgtct cggccatggc
    16321 accggtcggc gtgctggtct ccaccccggg aacggcgctc gccgcggcgg acacgatcac
    16381 cgtcacggca cgcgccccgg gcgggcacac cggctcaccg gattccggcc ccgacccggt
    16441 gctgttcgcc gcgtgcctca cccagcgcct gcacaccgtg gtgggccgtg acctaccgcc
    16501 cttcgagcag gcggtggtgt ccgtgcccgg catagcggca ccgtccgcgc cgggactgcg
    16561 cgcgccccgt gccaccctga ccgtcaatat ccgaaccttc gaagaacgcg tgcggaagac
    16621 ggtcctcggc cgcgtcgacg cgctggtgcg ggcggaggca gccgccgccg gcctcgcctt
    16681 cggcgacgac gtccggctga tccatgagac ccacgttccc cgagtggaga acaacgcgcc
    16741 ggtccgtgac cgactcaccg cggtccaccg cagccgactg tccatgggcc acctcaccgt
    16801 cccgcccgcg ctcgcctcgg acgatgtcag tcttctcgtc cgggccttcg gctgcgcggc
    16861 cgtgtactgg ttcgtcgggt ccggcgaacc cggcgggcgg ctcggcccgg tgcggcccgc
    16921 ctgccacacc gacgaatacc ttccccatcc tgcgacgctc gccgtcgcca ctgcagcgat
    16981 gcgcgaggca ctgctggccg ggctggccgg tgaactgtgc gagcctcgtc gcgctgctca
    17041 gcccgaccct gcggctcaga cggaagcgga gaaggcgtcc ccgcaaaaca gctcgtgcgg
    17101 gccgaggctc agctcgaccc gcacaagttg ggaatacggt cagtgtccga ggggggactt
    17161 gaacccccac gcccgataa
//
