LOCUS       BGC0000606             14244 bp    DNA     linear   BCT 28-MAY-2014
DEFINITION  Streptomyces lactacystinaeus lactazole biosynthetic gene cluster,
            complete sequence, strain: OM-6519.
ACCESSION   BGC0000606
VERSION     BGC0000606
KEYWORDS    .
SOURCE      Streptomyces lactacystinaeus
  ORGANISM  Streptomyces lactacystinaeus
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 20:00:36
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14244
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..2574
                     /gene="ltc74"
     CDS             1..2574
                     /codon_start=1
                     /gene="ltc74"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 109.2;
                     E-value: 4.2e-33)"
                     /gene_kind="biosynthetic"
                     /product="serine/threonine protein kinase"
                     /protein_id="BAO57433.1"
                     /sec_met_domain="LANC_like (E-value: 3.1e-20, bitscore:
                     61.4, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.2e-14, bitscore: 43.5,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPPDPGSAAVLGQEELRRRAEELAARAPGPHRPLRTDGQWWYL
                     PDPRMPELAHGWKLHLSARPEGFAALLDTVLPILLGRVCDVKFAVSAAALWELNSGRHG
                     AAAVGKAVTVYPRPEEVRSLGLELAQALAGREGPAVVSDRPVRPDAPVHYRYGPFRVTD
                     DEAQAGMAGPDGSLFPGLAEARYRRPPWADDPFEAADAPARPATTRVGAGRYRITAGIT
                     RAPSGHVYRAVELATGREVVIKQARAFVAEDGAGTDARGRLRHEQRVLDALAGIPGVPA
                     LVDYFRHGTDEYLVSAARGRIDLRREVLTAGPYDAGAGAGAGASAGAGAGAGTAGGRDW
                     WTLARRLLHVLDAVHSRGVVVCDLKPANVVLDPDGRPALVDFGVSALAGDRPPGATAGY
                     GLPGATGEDPTEDHYALGATLHHALTGLDPVVIDQDPATNRDRTLACLRAALPEPGHPA
                     AELVEGLLSFDPVHRAAAAARLREGPRPVRRGAPGGRSGGRPAEALDHTVTTCVRMARE
                     LVAADPGAERPRTLLSLYDGAAGLGLELLQHPERPDARAAAAELARWTAAHPALDHLDG
                     SLYQGRTGVDLFLAEAAAALGTEPPRPRRYEGTGVDQIGGTAGIGTGHLLLAALDPAAG
                     AHRAAAADCAADLAGRPLDDLGEEPNPGTAALAEGFAHGRAGVAHFLLAMPDEASRHAA
                     RQIVDGLAADLPRIAAAARAPGATRRYLSWCRGLAGLGTLLVQAGRRDGDDALIALAAE
                     AADTCRTLAPRTAQVFRCCGLAGVGDLFVDLAVATGEARHWAAAEELAALILTRAGGPP
                     DRPLLPGRRPDAEARAWAVGTPGVTTFLRRLARRGGPVPGLLPLH"
     source          1..14244
                     /db_xref="taxon:1332838"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces lactacystinaeus"
                     /strain="OM-6519"
     subregion       1..14244
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="RiPP"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..14244
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            2976..3149
                     /gene="lazA"
     CDS             2976..3149
                     /codon_start=1
                     /gene="lazA"
                     /product="lactazole precursor peptide"
                     /protein_id="BAO57434.1"
                     /transl_table=11
                     /translation="MSDITASRVESLDLQDLDLSELTVTSLRDTVALPENGASWGSCSC
                     QASSSCAQPQDM"
     gene            3371..6013
                     /gene="lazB"
     CDS             3371..6013
                     /codon_start=1
                     /gene="lazB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     83.1; E-value: 1.7e-25)"
                     /gene_kind="biosynthetic"
                     /product="lantibiotic-type dehydratase"
                     /protein_id="BAO57435.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.6e-34, bitscore:
                     108.2, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPNRAAPPRDARAPVPAPAPAAYAARHALVRSTVLAWPAQSAATA
                     HTRALLRDLAAAEAAAEALRPALCDDLYAGRAGHDEEFHRRVVLPLRRDLHNGRTPRAA
                     LLDRLADLPRRIPRLAEWLELRRLRARLLDALADAVPPALAAERAALADICREPVFTRA
                     VALTSADLLRAVANTAGATGEPPRGRARKEEAAVLRHALRATAKTSPLSWFTAVGWSSE
                     DGEAAAGEPRACVRENRALVTALVQALLDDPRRSRTLPHRMTSAARVADGRARYARAEA
                     LFAGGRFLVTREEEVELAARPELALLASLAATPAPPDRLAAGLAEALGRPGGDPGAQRF
                     VDQLVTARLLVPTEPVDPQDRHPLRSLAGWLRQWPQDAELAHRIEQLDRQNAELAVTTG
                     EHRPELLAVLAERWRLLLADAGRPVPQEAAPLSVLSEDVHAPAPPQPRPGAADRAALAE
                     LTALAELFDHAHLMRRAARGRFVARYGVGGVCDAPWDFAADLADSWADPTPPDELAALR
                     EEFAKLPEQDGELVLPAERIRALAARLPHWTAARPLSYSWFVQRGSADGLLCVNHVYGG
                     WGRFTSRFLDGLAPQAATEVARQLRSGLGAGARAAQIRPVGGFNANLHPRLLADEIGPD
                     RQWTGLAESDLDLVHDPVDDQLRLRLRTTGELLDVLYLGFLAPVMLPRRLGPLLNDHPE
                     GVVDFRPLLPRTTLAAPGGTVLRTPRLRHRHVVLARRRWLLPAGVLDALRADLAADAGP
                     DGVPAAAVARWRARLDLPEQLFLHPAPAAADPAGTPGDAFVAHLRAPKPQPVDLGNPLH
                     LRHLAKWLTRHPRGAVLEEALPAIAGHPEPTRAVELVVETYRPGRGSEQAAGAFESVRT
                     AIAEEAPDE"
     gene            6006..7226
                     /gene="lazC"
     CDS             6006..7226
                     /codon_start=1
                     /gene="lazC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /product="lantibiotic-type dehydratase"
                     /protein_id="BAO57436.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.1e-17, bitscore:
                     53.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDPADGRGAVTAWDVVLYHYRPDKARALREAVLPLARQAAAEGL
                     AAHVERHWRFGPHLRLRLRGPEARVAGAAQRAAEALRAWAAAHPSVADRSDEQLLAEAA
                     VAGRAELIAPPYAPLVPDNTVVAAPADRSAEDALRALIGAESAELREELLRTGLPALDS
                     ACHFLGAHGDTPQARVQLVVTALAAHATAHPDGLVGAHYSVLSHLEDFLVHEDPDGSLR
                     AAFERRWEQSGRAVTALVGRIADGGARDWERDWAHWSATAWSLAERRLTAGADLGGRHA
                     EYRERAEALGDPATAERWNAELRTRYSEFHRMLQRADPDGRMWHRPDYLINRAGTNGLY
                     RLLAICDVRPMERYLAAHLLVRSVPELTGHRWQTLLGAAEQPGGPEQSGAAGATGGAGR
                     TKLEGAA"
     gene            7223..8920
                     /gene="lazD"
     CDS             7223..8920
                     /codon_start=1
                     /gene="lazD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic"
                     /product="hypothetical protein"
                     /protein_id="BAO57437.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 3.3e-23,
                     bitscore: 70.9, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAEPDAVRPRLRPGVAVTPLREGLHLRGRESSVTLEGSRALPAL
                     WQVLAARLGPQAEAADAAVEATVEPRVAAALATVTARLREHGLLVDHPDGVRLPPWPGA
                     VADDPGGAEAALAAARPVVAAADPDGPSARAMARALARGGTAAPAVVAEPGLPAGRVVA
                     TADGPAGTELAVAVQCGADGGFVTEPADPARARTDAAALAARLEPAPVADPPPVLLALL
                     AAAGAQRLLCAVAGLPDPGEPADDPRLLDGRPTVLIADAAPPHAEHHPWAAGPGAVAAP
                     PGSLAEALRRVNALGDPRLGVLDAPSAGDLPQLPVALVSCATPAGPLAAGAVRTDLARL
                     AAACRSAELHLAAVGGGAVPVVGVDPDHALGLALRRAVLARAVRGDRPLPDDRAARGDR
                     TVPESAWREHPQAGHWYGVLARRLGRAPEPTIRQLSGESVYLAQVEEGRAVEATPADAV
                     AHAALAALTRLMARGAGLAAVHHTVLSGAAAPLAAAGRTPAAWTDLGWADRWLADIADR
                     EADLHAALVRITGLRTARWRPATPEARPFADALDGCGFTALTAEGGRP"
     gene            8917..10983
                     /gene="lazE"
     CDS             8917..10983
                     /codon_start=1
                     /gene="lazE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_kind="biosynthetic"
                     /product="cyclodehydratase"
                     /protein_id="BAO57438.1"
                     /sec_met_domain="TIGR03604 (E-value: 4.5e-85, bitscore:
                     274.9, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 3.7e-72, bitscore: 233.0,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSELPVLTPVEALAATSGTAVVHLTEWTLGLAARLSRHALAHPVR
                     LVPVREDGALTVVGPVLAPGAPACLACVEYQRLATAGGRVPWQSPALALGGTGTPAFAE
                     AVTALAAELAKGPEAAESAEGAGSPEAAESAEGAGSPEAAESADGAGSPEAAESADGAG
                     SPEAAESADGAGSPEAAESADGATVHVVHGGRATWSTHRVRPVGGCEVCRPLPPDTPEA
                     ARLPATPRPLPDPAVLRGPNDRTDAGQLRAELYDERFGPVRRLFRTEDSAFALTTAWVT
                     DGRALDDGGYGRAADFRSSERVALFEAVERHAGMRPLGRRTVLRASYAELARELGPDAV
                     LDPARLGLPDDPHQGHPTPATAPYTPELVLDWVHGWSLTRRRPVAVPERVAYWEVPGRD
                     RPRVVYESSNGCGLGNSPQEAALYGLFEVAERDAFLMAWYARTPLPGVAVPTEDPQIAE
                     LADRAELFGYHLTLLDATNDLGVPAVIALCRHRGDHPDAPRTLLAAGAHHDPRTAIRSA
                     VAEVVTNVQEAPHRSTAPGGPRDPQRLRPMLERPELVVSLDDHVGLNTLPEAQPRLDFL
                     FAGPPPVPWTERWPGDPEPVTDLTDLLERTVTRLAGEDLEVLVVTQDEPGVRDRLGLHC
                     AKVVVPGTLPMTFGHANRRTRGLSRLLEVPYRLGRTPAPLRHDELPLHPHPFP"
     gene            11064..12737
                     /gene="lazF"
     CDS             11064..12737
                     /codon_start=1
                     /gene="lazF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_kind="biosynthetic"
                     /product="dehydrogenase"
                     /protein_id="BAO57439.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.5e-48, bitscore:
                     155.1, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF00881 (E-value: 4e-15, bitscore: 45.5,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTHALPATTWHSLHLALPLPAREADAFLTEDLAPLMDGLAGTDW
                     FFIRYGEGGPHLRIRHRGPGPAPASLAADLTRLATRRTAPDGPFADGHGTVTEVPYEPE
                     TERYGGAALLPIAEEVFTHSTRAAVRALHALGAAPEKRLQLALDLAHTTAYALGLDELA
                     ASRWLRRHAAAWRWVTEFRPLPGAAVHTRVNTVFARQRETLARRARELRAALDAGTASP
                     WLGDWAARAAEAAARMRAVAAAEAAAPASAAEEAEERLEWIWASQLHMLFNRLGVGPDE
                     ERAVCRLAARTLLETGQPFTFFPADHHAPDHQYLERSKFQIGRGEDTALRDLPHDPAPS
                     PRPGDLPLPADPLPPVTLADALRTRRSTRGPLTGPLTAGALGGLLWSAFAPAPDTGHRP
                     YPSAGALHTVRLRLLALAVDGLPAGTYHCLPEHRSLRPIGPAPALDDLKALSSYLSRPA
                     EDPDAIGVDRAPAVLAVYLDLARLRRRYGLRALRLGVLEAGHLAQNLLLTSAAFGLGTT
                     PLGGLQDDLAHELLGLDDLGEPIQYLLPLGRPGTVPVIME"
     gene            complement(12981..13334)
                     /gene="ltc66"
     CDS             complement(12981..13334)
                     /codon_start=1
                     /gene="ltc66"
                     /product="peptidase"
                     /protein_id="BAO57440.1"
                     /transl_table=11
                     /translation="MDGVAARVAGGATVEFRPSGSSMVPLIRSRQLVAVAPVDPSKLEL
                     GDIVLARVAGTVYLHLVSALDPARRRVQISNNRGRINGWTGHDRVFGICVAVEGTPRAG
                     AADKTSAASPARP"
     gene            complement(13417..14244)
                     /gene="ltc65"
     CDS             complement(13417..14244)
                     /codon_start=1
                     /gene="ltc65"
                     /product="creatininase"
                     /protein_id="BAO57441.1"
                     /transl_table=11
                     /translation="MTHGYSVFAETMADLTWPQVEAAAARGARVLLPTGVIEQHGPHLP
                     LGTDAYGAYQLCRLVKTELERRGEETLIALPVHWGINQVSAGFAGTFRTRPETAAALHT
                     DILDSLATDGFRRIHLINHQGDLAHNLMLLDVVREQHRKGRTGVVLVEPDFVADRLADA
                     ADGTPAALGVFAMRPLFEGLELSGELGVHAEEIEAAMMMRWFPETVDHEAMAGLKPTGL
                     GTDDLAEWRKGGEHARRVTPQGYFGAPFPKDPFLFRFHERMARAMADVVSARS"
ORIGIN
        1 atgagcacac cgcccgaccc cggctccgcc gcggtcctgg gacaggagga actgcggcgc
       61 cgggccgagg aactggccgc ccgggcgccc ggcccgcacc gcccgctgcg caccgacggc
      121 cagtggtggt acctcccgga cccccggatg ccggagctgg cccacggctg gaaactccac
      181 ctgtccgccc gaccggaggg cttcgcggcc ctgctggaca ccgtccttcc catcctgctc
      241 ggccgcgtct gcgacgtgaa gttcgcggtg agcgccgcgg cactgtggga actcaacagc
      301 ggccggcacg gcgccgccgc cgtcggcaag gccgtcacgg tctacccccg gccggaggaa
      361 gtccgatccc tggggctgga gttggcgcag gcactggcag gccgggaagg ccccgccgtg
      421 gtgagcgacc gccccgtccg gcccgacgcc ccggtgcact accgctacgg gccgttccgc
      481 gtcaccgacg acgaggcgca ggccggcatg gcgggcccgg acggctcgct gttccccgga
      541 ctggccgagg cccgctaccg tcggccgccg tgggcggacg accccttcga agcggccgac
      601 gcccccgccc gcccggcgac cacccgggtc ggagccggcc gctaccggat caccgccggc
      661 atcacccggg cgcccagcgg ccacgtctac cgcgcggtcg aactcgccac cgggcgcgag
      721 gtggtgatca agcaggccag ggccttcgtc gccgaggacg gcgcgggcac cgacgcgcgc
      781 ggccggctgc ggcacgagca gcgggtgctc gacgcgctgg ccgggatccc cggcgtgccc
      841 gcactggtcg actacttccg gcacggcacc gacgagtacc tggtcagtgc cgcccgaggc
      901 cggatcgacc tgcgccgcga ggtgctcacc gccggcccgt acgacgccgg tgccggtgcc
      961 ggtgccggtg ccagtgccgg tgccggtgcc ggtgccggga cagcgggcgg acgggactgg
     1021 tggacgctgg cgcgccggct gctgcacgtg ctcgacgcgg tgcactcccg cggcgtggtg
     1081 gtctgcgacc tcaagcccgc caacgtggtg ctcgacccgg acggccggcc cgcgctggtc
     1141 gacttcggcg tgagcgccct ggccggcgac cgcccgccgg gcgccaccgc cgggtacggc
     1201 ctgccgggcg ccaccggcga agaccccacc gaggaccact acgcgctggg cgccaccctg
     1261 caccacgccc tcaccggcct cgacccggtg gtgatcgacc aggacccggc gaccaaccgc
     1321 gaccgcaccc tcgcctgcct gcgcgccgcc ctcccggagc ccgggcaccc ggcggcggag
     1381 ctggtcgagg gcctgctgag cttcgacccg gtacaccgcg ccgccgcggc ggcccggctg
     1441 cgggagggac cccgcccggt ccgacgcggt gcccccggcg gacggagcgg cggccggccg
     1501 gccgaggccc tcgaccacac cgtcaccacc tgcgtccgga tggcccgcga actggtcgcc
     1561 gccgaccccg gcgcggagcg cccccggacc ctgctctcgc tgtacgacgg cgcggccgga
     1621 ctcggcctcg aactgctcca gcaccccgag cgcccggacg cccgggccgc cgccgccgaa
     1681 ctggcccgct ggacggccgc ccacccggcc ctcgaccacc tcgacggctc gctgtaccag
     1741 ggccgtacgg gcgtcgacct gttcctcgcc gaggccgccg ccgcgctggg caccgagccc
     1801 ccgcggcccc gccggtacga ggggacgggc gtggaccaga tcggcggcac cgccggcatc
     1861 ggcaccgggc acctgctgct cgccgccctc gacccggcgg ccggagcaca ccgcgcggcg
     1921 gcggccgact gcgccgccga cctggccggc cggccgctgg acgacctcgg ggaggagccc
     1981 aaccccggca ccgcggccct ggccgagggc ttcgcccacg gccgcgcggg cgtcgcccac
     2041 ttcctgctcg cgatgcccga cgaggcgtcc cggcacgccg cccggcagat cgtggacgga
     2101 ctcgcggccg acctcccgcg catcgccgcc gccgcccgcg cgcccggggc gacccgccgc
     2161 tacctgtcct ggtgccgggg cctggccggg ctcggcaccc tgctggtcca ggccggccgg
     2221 cgggacggcg acgacgcgct gatcgccctg gccgccgagg cggccgacac ctgccggacg
     2281 ctcgccccga ggaccgcgca ggtgttccgc tgctgcggcc tcgcgggcgt cggggacctc
     2341 ttcgtcgacc tcgcggtggc caccggcgag gcccggcact gggcggccgc cgaggaactg
     2401 gcggccctga tcctcacccg ggccggcggc ccgcccgacc ggccgctgct gcccggccgc
     2461 cggccggacg cggaggcccg ggcctgggcg gtcggcacgc ccggcgtcac caccttcctg
     2521 cgccgcctcg cccggcgcgg cggtccggtg ccgggactgc tgccgctgca ctgaccggcc
     2581 ccgaccggtc cgggccgaat ggtgacgctt cgtcagtttc actgtgcggc aaaaggatcc
     2641 gtgggccgcc cgtccgggcc gccccctgcc tcggcgcccc ggaccgtccc ggcggaccgc
     2701 acccgccgat ggggcgggga tccgtgagga ctggggttcc gcttgagtgg aaacggtatt
     2761 gagccgacca ggcgcgggct ccggccaagg tggcggcggc ccgtaccgcc gcccgccgcc
     2821 cgccgcctag agtcgccgtc gggcggtgcg aagcccgggt ccgagcgacc cgcgggcggc
     2881 gcacccacgg ggggcccggc acatcccgca acatctgatc gcaggcccga ccttccggtt
     2941 cgaccggcag gcctgccaac gtgagggaga acgccatgtc cgacatcacc gcgtcccgtg
     3001 tcgagagcct cgaccttcag gacctcgacc tcagcgagct gaccgtcacc tcgctgcgcg
     3061 acaccgtcgc gctgcccgag aacggcgcct cctggggctc ttgttcctgc caggcctcgt
     3121 cctcctgcgc gcagccgcag gacatgtaag gaacagcccg aacccgtcgg ccgggccctt
     3181 tgaggccgcg gccacggtgc caggagggac ccggcgcgtc caccggacgc gccgggttcg
     3241 tcccgcgtcc acagcgcctg ccgcgggtcc gcaggacctg tcgcgcggac ccggtcgggc
     3301 cgacggcgcc gcggccggaa ccgaccagtc ccacgagacg cgccccaggc cccgtcggag
     3361 ggaaccgccc atgcccaacc gcgccgcccc gccccgggac gcccgggcgc cggtccccgc
     3421 accggctccg gccgcgtacg ccgcgcgcca cgccctggtg cgctcaaccg tgctcgcctg
     3481 gcccgcccag tccgccgcca cggcgcacac ccgggcgctg ctgcgcgacc tcgccgccgc
     3541 cgaggccgcg gccgaggccc tgcggccggc cctctgcgac gacctgtacg ccggccgggc
     3601 cgggcacgac gaggagttcc accgcagggt cgtgctgccg ctgcgccgcg acctgcacaa
     3661 cgggcgaacg ccgcgggcgg cgctgctcga ccggctcgcc gacctgccgc gccggatccc
     3721 gcggctcgcc gagtggcttg agctgcgacg gctgcgggcc cggctgctgg acgcgctcgc
     3781 cgacgccgtc ccgcccgccc tcgccgccga acgggccgcc ctcgcggaca tctgccggga
     3841 gcccgtcttc acccgggccg tcgcgctcac cagcgccgac ctgctgcgcg cggtggccaa
     3901 caccgcgggc gcgaccgggg aaccgccgcg cggccgggca cgcaaggagg aggccgccgt
     3961 gctgcggcac gccctgcggg ccaccgccaa gaccagcccg ctgtcctggt tcaccgccgt
     4021 cggctggtcc tccgaggacg gcgaagccgc ggccggcgag ccccgcgcct gcgtccggga
     4081 gaaccgggcg ctggtcaccg cgctcgtcca ggccctgctc gacgaccccc gccgcagccg
     4141 cacgctgccg caccggatga ccagcgcggc ccgggtcgcc gacggccggg cccgctacgc
     4201 ccgcgcggag gcgctgttcg cgggcgggcg cttcctggtc acccgggagg aggaggtcga
     4261 actcgccgcc cggcccgaac tcgccctgct cgcctcgctc gcggccaccc cggccccgcc
     4321 ggaccggctc gccgccgggc tcgccgaggc cctcggacgg ccgggcggcg acccgggcgc
     4381 gcagcgcttc gtggaccagc tcgtcacggc ccggctgctg gtgcccaccg aaccggtcga
     4441 cccgcaggac cggcacccgc tccgcagcct ggccgggtgg ctccggcagt ggccgcagga
     4501 cgccgagctg gcccaccgga tcgaacaact cgaccggcag aacgccgagt tggccgtgac
     4561 cacgggcgag caccgccccg aactgctggc cgtcctcgcc gagcgctggc ggctgctgct
     4621 ggccgacgcc ggccggccgg tgccgcagga ggccgcgccg ctcagcgtcc tcagcgagga
     4681 cgtccacgcg ccggctccgc cgcagccccg gccgggcgcg gccgaccggg cggcgctcgc
     4741 cgaactcacc gcgctcgccg agctgttcga ccacgctcac ctgatgcgcc gggctgcccg
     4801 gggccgcttc gtcgcccgct acggcgtcgg cggggtgtgc gacgccccct gggacttcgc
     4861 tgccgacctg gcggactcct gggccgatcc gacacccccg gacgaactgg ccgcgctgcg
     4921 cgaggagttc gcgaagctgc cggagcagga cggcgaactc gtgctccccg ccgagcggat
     4981 ccgcgccctg gccgcccgac tgccccactg gaccgcggcc cgcccgctca gctactcctg
     5041 gttcgtccaa cgcggctccg cggacggcct gttgtgcgtc aaccacgtct acggcggctg
     5101 ggggcgcttc accagccgct tcctcgacgg cctggccccg caggccgcca ccgaggtcgc
     5161 ccggcagctg cggtccggcc tcggcgccgg cgcccgcgcc gcccagatcc ggccggtcgg
     5221 cggcttcaac gccaacctgc acccgcgact gctcgccgac gagatcggcc ccgaccgaca
     5281 gtggaccggc ctcgccgagt ccgacctcga cctcgtgcac gacccggtcg acgaccagct
     5341 ccggctgcgg ctgcgcacca ccggcgagct gctcgacgtc ctctacctgg gcttcctcgc
     5401 accggtcatg ctgccccggc ggctcggccc gctgctcaac gaccaccccg agggagtcgt
     5461 cgacttccgg ccgctgctgc cgcgcaccac cctcgccgcg cccggcggca ccgtgctgcg
     5521 caccccgcgg ctgcgccacc ggcacgtcgt cctcgcccgc cgccgctggc tcctgccggc
     5581 cggagtgctc gacgccctgc gggccgacct cgccgccgac gcgggccccg acggggtccc
     5641 ggccgcggcc gtcgcccgct ggcgggcccg gctcgacctg cccgaacagc tcttcctcca
     5701 ccccgcaccg gccgcggccg accccgcggg cacgcccggc gacgccttcg tcgcccacct
     5761 gcgagccccc aagccgcagc ccgtcgacct cggcaacccg ctgcacctgc gccacctcgc
     5821 caaatggctc acccggcacc cgcgcggcgc ggtactggag gaggccctcc cggccatcgc
     5881 gggtcacccg gagccgaccc gggccgtgga actcgtggtg gagacgtacc ggcccggccg
     5941 gggcagcgag caggcggccg gcgccttcga atccgtccgt accgccatcg ccgaggaggc
     6001 gcccgatgag tgacccggcc gacggccgag gggccgtgac cgcctgggac gtggtcctgt
     6061 accactaccg gcccgacaag gcccgcgcgc tgcgcgaagc cgtcctgccg ctggcccggc
     6121 aggcggcggc cgaggggctg gccgcccacg tcgagcggca ctggcggttc ggaccgcacc
     6181 tgcggctgcg gctgcgcggc ccggaggcac gggtggccgg ggcggcgcag cgggccgccg
     6241 aggcgctgcg ggcgtgggcg gccgcgcacc cctccgtggc cgaccggtcg gacgagcagc
     6301 tgctcgccga ggccgccgtc gccggacgcg cggagctgat cgcgccgccg tacgcgccgc
     6361 tggtgccgga caacaccgtg gtggcggcgc ccgccgaccg gtccgccgaa gacgccctgc
     6421 gggcgctgat cggcgccgaa tccgccgagc tgcgcgagga gttgctgcgg accggcctgc
     6481 ccgccctcga ctcggcctgc cacttcctcg gcgcgcacgg cgacaccccg caggcgcggg
     6541 tgcagctggt ggtgacggcg ctcgcggcac acgccaccgc gcacccggac gggctggtcg
     6601 gcgcgcacta ctcggtgctc tcgcacctgg aggacttcct ggtccacgag gacccggacg
     6661 gcagcctgcg ggccgccttc gagcgccgct gggagcagag cggccgggcg gtcaccgcgc
     6721 tggtcggccg gatcgccgac ggcggcgcgc gcgactggga acgggactgg gcgcactggt
     6781 cggcgaccgc ctggagcctg gccgagcggc ggctgacggc cggcgccgac ctcggcggcc
     6841 gccacgccga gtaccgggag cgcgccgagg cactcggcga cccggccacc gccgagcgct
     6901 ggaacgccga actgcgcacc cgctacagcg agttccaccg aatgctgcag cgcgccgacc
     6961 ccgacggcag gatgtggcac cgtcccgact acctgatcaa ccgggccggc accaacggcc
     7021 tgtaccggct gctcgcgatc tgcgacgtcc gcccgatgga gcgctacctg gccgcccacc
     7081 tgctggtgcg cagcgtgccc gaactgaccg ggcaccgctg gcagacgctc ctcggcgccg
     7141 cggagcagcc gggcggcccg gagcagtcgg gcgccgcggg ggcgacgggc ggcgcggggc
     7201 gcacaaagct ggagggggcg gcatgacggc cgaaccggac gccgttcggc cccgcttgcg
     7261 ccccggggtg gcggtgacgc cgctgcgcga agggctgcac ctgcgcgggc gcgagagcag
     7321 cgtcaccctg gagggcagcc gggcgctccc ggcgctgtgg caggtgctcg ccgcccggct
     7381 cgggccgcag gcggaggccg ccgacgcggc cgtcgaggcg accgtcgagc cgagggtggc
     7441 ggccgcgctg gccaccgtca ccgcccggct gcgcgagcac ggcctgctcg tggaccaccc
     7501 ggacggggtc cgactgccgc cctggccggg cgcggtggcg gacgaccccg gcggtgcgga
     7561 ggcggccctg gcggccgccc gcccggtggt ggccgccgcg gacccggacg gcccgtcggc
     7621 ccgcgcgatg gcgcgcgccc tggcccgggg cggtacggcg gccccggcgg tggtcgccga
     7681 gcccgggctg cccgccggcc gggtggtggc cacggcggac ggtccggcgg gaacggagct
     7741 ggcggtcgcg gtgcagtgcg gtgcggacgg cggcttcgtc acggagcccg ccgacccggc
     7801 ccgggcccgg acggacgcgg cggcgctcgc cgcccggctg gaacccgccc ccgttgcgga
     7861 cccgccgccc gtgctcctcg cgctgctcgc cgcggccggc gcccagcggc tgctctgtgc
     7921 cgtcgcgggc ctgccggacc cgggcgagcc ggccgatgat ccgcggctgc tcgacgggcg
     7981 ccccaccgtc ctgatcgccg acgccgctcc gccgcacgcc gagcaccacc cgtgggcggc
     8041 gggccccggg gccgtcgccg cgccgcccgg gagcctcgcc gaggcgctgc gccgggtgaa
     8101 cgccctcggt gacccccggc tgggcgtgct ggacgcgccc tccgcgggcg acctcccgca
     8161 gctgcccgtg gccctggtct cctgcgccac ccccgccggc ccgctggcgg ccggggcggt
     8221 gcggacggac ctcgcccggc tggccgccgc ctgtcggtcc gccgaactgc acctggcggc
     8281 ggttggcggg ggagccgtgc cggtggtcgg cgtcgacccg gaccacgccc tcggcctggc
     8341 cctgcgccgc gccgtgctcg cccgggcggt gcggggcgac cggccgctcc cggatgaccg
     8401 ggcggcgagg ggcgaccgga cggtgcccga gtccgcctgg cgggaacacc cgcaggccgg
     8461 gcactggtac ggcgtcctgg cccgccggct cggccgagca cctgaaccga cgatccgtca
     8521 actctccggg gagtcggtgt acctggcgca ggtggaggag ggcagggcgg tcgaggccac
     8581 gcccgccgac gccgtcgccc acgccgcact ggccgccctc acccggctga tggcccgggg
     8641 cgccggcctc gccgccgtcc accacaccgt cctgtccggc gccgccgccc cgctcgccgc
     8701 cgccggccgg accccggcgg cctggaccga cctgggctgg gccgaccgct ggctcgccga
     8761 catcgccgac cgggaggcgg acctgcacgc cgccctggtc cggatcaccg gtctgcgcac
     8821 cgcccgctgg cggcccgcca cccccgaggc ccgcccgttc gccgacgccc tggacggctg
     8881 cggcttcacg gccctcacag ccgaaggagg ccgcccatga gcgagctgcc ggtcctgacc
     8941 ccggtcgagg cgctggccgc cacgagcggc accgccgtcg tccacctcac cgaatggacc
     9001 ctgggcctgg ccgcccggct cagccggcac gccctggcac accccgtacg cctggtgccg
     9061 gtgcgcgagg acggcgcgct gaccgtggtc gggccggtgc tcgcccccgg cgcaccggcc
     9121 tgcctcgcct gcgtcgagta ccagcggctc gccaccgccg gcggccgggt gccctggcag
     9181 agcccggccc tggcgctggg cggcaccggc accccggcct tcgccgaggc cgtgaccgcg
     9241 ctcgccgccg agctggccaa gggccccgag gccgcggaga gcgcggaggg cgccgggagc
     9301 cccgaggccg cggagagcgc ggagggcgcc gggagccccg aggccgcgga gagcgccgac
     9361 ggcgccggga gccccgaggc cgcggagagc gccgacggcg ccgggagccc cgaggccgcg
     9421 gagagcgccg acggcgccgg gagccccgag gccgcggaga gcgccgacgg cgccaccgtc
     9481 cacgtggtgc acggcggccg ggccacctgg tccacccacc gggtccgccc cgtcggcggc
     9541 tgcgaggtct gccggccgct gccccccgac acgcccgagg ccgcccggct gcccgccacc
     9601 ccccgcccgc tgcccgaccc ggccgtcctg cgcgggccca acgaccgcac cgacgcgggg
     9661 cagttgcggg ccgaactgta cgacgagcgg ttcggcccgg tccgccggct gttccgcacc
     9721 gaggactcgg ccttcgccct caccaccgcc tgggtgaccg acggccgggc gctcgacgac
     9781 ggcgggtacg ggcgcgccgc ggacttccgc tccagcgagc gggtcgcgct gttcgaggcg
     9841 gtggaacggc acgccggcat gcggccgctc gggcgccgca ccgtcctgcg cgcctcctac
     9901 gccgaactgg cacgcgagtt gggccccgac gccgtcctcg acccggcccg gctcggcctg
     9961 cccgacgacc cccatcaggg gcaccccacc ccggccaccg ccccgtacac ccccgagctg
    10021 gtcctcgact gggtgcacgg ctggtcgctc acccgccgcc gcccggtcgc cgtcccggag
    10081 cgcgtcgcct actgggaggt tcccggccgc gaccgccccc gggtggtcta cgagtcctcg
    10141 aacggctgcg gactcggcaa cagcccccag gaggccgcgc tctacggcct gttcgaggtc
    10201 gccgagcgcg acgccttcct gatggcctgg tacgcccgca ccccgctgcc cggcgtcgcc
    10261 gtccccaccg aggacccgca gatcgccgaa ctcgccgacc gcgccgagct gttcggctac
    10321 cacctcaccc tgctcgacgc caccaacgac ctcggcgtac ccgccgtgat cgccctctgc
    10381 cgccaccgcg gcgaccaccc cgacgccccg cgcaccctcc tggccgccgg agcccaccac
    10441 gacccccgga cggcgatccg ctccgccgtc gccgaggtgg tcaccaacgt ccaggaggcg
    10501 ccccaccgct ccaccgcccc gggcgggccg cgcgacccgc agcggctgcg gccgatgctg
    10561 gagcgcccgg agctcgtcgt ctccctggac gaccacgtcg gcctcaacac cctgcccgag
    10621 gcccagcccc gcctcgactt cctcttcgcc ggcccgccac cggtgccctg gaccgagcgc
    10681 tggcccggcg accccgaacc ggtcaccgac ctcaccgacc tgctggagcg gacggtcacc
    10741 cggctggccg gggaggacct ggaggtcctc gtggtcaccc aggacgagcc cggcgtccgc
    10801 gaccggctcg gcctgcactg cgccaaggtc gtcgtccccg gcacgctgcc gatgaccttc
    10861 ggccacgcca accgccgcac ccggggcctg tcccgcctgc tggaggtccc gtaccgcctc
    10921 ggccgcaccc ccgcgccgct gcgccacgac gaactcccgc tccacccgca cccgttcccc
    10981 tgagggcgtg tcttccggat cacgccgccc gcttgtccga cgtgatccga aagacacgcc
    11041 cctggcccac cggagagcac acgatgacca cccacgcgct gccggccacc acctggcaca
    11101 gcctgcacct cgcgctgccg ctgcccgccc gcgaggccga cgccttcctc accgaggacc
    11161 tcgccccgct gatggacggg ctcgccggca ccgactggtt cttcatccgc tacggcgagg
    11221 gcggccccca cctgcgcatc cgccaccgcg gcccgggccc ggcgcccgcc tccctcgccg
    11281 ccgacctcac ccgcctcgcc acccgacgca ccgcgcccga cggcccgttc gcggacgggc
    11341 acggcaccgt gacggaggtc ccgtacgagc ccgagaccga gcgctacggc ggcgcggccc
    11401 tgctgccgat cgccgaagag gtgttcaccc actccacccg cgccgccgtc cgcgccctgc
    11461 acgccctcgg cgcggccccc gagaagcggt tgcagctcgc cctcgacctc gcccacacca
    11521 ccgcgtacgc gctcggcctc gacgaactcg ccgcctcccg ctggctgcgc cgccacgccg
    11581 ccgcctggcg ctgggtcacc gagttccggc cgctgccggg cgccgccgtg cacacccggg
    11641 tcaacaccgt gttcgcccgc cagcgggaga cgctggcccg ccgcgcccgg gagctgcgcg
    11701 cggcactgga cgccggcacg gccagcccct ggctggggga ctgggcggcg cgggccgccg
    11761 aggccgccgc ccggatgcgg gccgtcgcgg ccgccgaggc cgccgcgccc gcctcggccg
    11821 ccgaggaggc cgaggagcgc ctggagtgga tctgggcctc ccagctgcac atgctgttca
    11881 accggctcgg cgtcggcccc gacgaggaac gggcggtctg ccgcctcgcc gcccgcaccc
    11941 tgctggagac cggacagccg ttcaccttct tccccgccga ccaccacgcc cccgaccacc
    12001 agtacctgga acgcagcaag ttccagatcg gccgcggcga ggacaccgcc ctgcgcgacc
    12061 tgccgcacga cccggccccg agcccccgcc ccggcgacct cccgctgccc gccgacccgc
    12121 tgccgcccgt caccctcgcc gacgccctgc gcacccgccg ctccacccgc ggcccgctga
    12181 ccggcccgct caccgccggc gcgctcggcg gactgctctg gtccgccttc gcccccgccc
    12241 ccgacaccgg ccaccgcccg taccccagcg cgggcgccct gcacaccgtc cggctgcgcc
    12301 tgctcgccct cgccgtcgac ggcctgcccg ccggcaccta ccactgcctc cccgaacacc
    12361 gcagcctgcg cccgatcggc ccggcccccg ccctcgacga cctcaaggcg ctctcctcct
    12421 acctctcccg cccggccgag gaccccgacg ccatcggcgt cgaccgggcc cccgccgtcc
    12481 tcgccgtgta cctcgacctc gcccggctgc gccgccgcta cggtctgcgc gccctgcgcc
    12541 tcggcgtcct ggaagccgga cacctggccc agaacctgct cctgacctcc gccgccttcg
    12601 gcctcggcac cacccccctc ggcggcctcc aggacgacct cgcccacgaa ctcctcggcc
    12661 tggacgacct cggcgagccg atccagtacc tgctcccgct cggccggccg gggactgtac
    12721 cggtgatcat ggagtgagta ccctcggccc gtgaccgatc acggcatcgc cctccccgcg
    12781 ttccgcctcc acgtcgtgcc cgccgtggtg gcgctggcca gcccgacctg gcagcgtgag
    12841 gtgtggctcg accgggacga gttcgaggac ctcgcccaca ccgtgcacgt gctcttcgac
    12901 gacttctgcg acgcgaacga tccgggaccc ctggggcgtg attgtcggac acgccccgga
    12961 ccgaggcggt cccgcgcgcc tcagggccgg gcgggggagg cagccgaggt cttgtccgcc
    13021 gccccggccc ggggcgtgcc ctcgacggcg acgcagatgc cgaagacccg gtcgtggccg
    13081 gtccagccgt tgatgcggcc ccggttgttg ctgatctgca cgcgccgcct ggccggatcg
    13141 agggccgaca ccaggtgcag gtacacggtt ccggcgaccc gggcgagaac gatgtcgccg
    13201 agctccagct tggacgggtc gaccggggcg acggccacca gctgccgact gcggatcagc
    13261 gggaccatcg acgaaccgct cggcctgaac tcgacggtgg ctccgccggc gaccctggcc
    13321 gccaccccat ccaatgcacc catccgccga gcgtggcaga tccgcccgtg cgggcccaac
    13381 cggtttttcg ctcccccagg cccgccggtc cgtcactcac gaccgcgcgg acaccacgtc
    13441 cgccatcgcg cgggccatcc gctcatggaa cctgaacagg aacgggtcct tggggaaggg
    13501 cgcgccgaag tagccctgcg gggtcacccg gcgggcgtgc tcgccgccct tccgccactc
    13561 cgcgaggtcg tccgtcccga ggccggtcgg cttgagcccg gccatcgcct cgtggtcgac
    13621 ggtctcgggg aaccagcgca tcatcatcgc cgcctcgatc tcctccgcgt gcacgcccaa
    13681 ttcgccgctc agctccaggc cttcgaacag tggccgcatc gcgaacacgc ccagggccgc
    13741 gggagtcccg tcggcggcgt cggcgagccg gtcggccacg aagtccggct cgaccagcac
    13801 cacgcccgtg cggcccttcc ggtgctgctc gcgcacgacg tccagcagca tcaggttgtg
    13861 ggcgaggtcg ccctggtggt tgatcaggtg gatgcgccgg aagccgtccg tggcaaggga
    13921 gtccaggatg tcggtgtgca gtgccgccgc cgtctcgggg cgggtgcgga aggttccggc
    13981 gaagccggcc gagacctggt tgatccccca gtgcaccggc agggcgatca gggtctcctc
    14041 cccgcgccgc tccagttccg tcttcaccag ccggcagagc tggtaggcgc cgtaggcgtc
    14101 ggtgccgagc ggaaggtggg ggccgtgctg ttcgatgacg ccggtcggca gcagcacgcg
    14161 cgcgcccctg gcggccgccg cctcgacctg cggccaggtg aggtcggcca tcgtctccgc
    14221 gaacaccgag tacccgtggg tcat
//
