Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000610.1:
Cluster 1RiPP134713

BGC0000610, nosiheptide biosynthetic gene cluster from Streptomyces actuosus. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: nosiheptide
PubChem ID: 70691386
SMILES string: Copy to clipboard
Molecular formula: C51H43N13O12S6
Average molecular mass: 1222.344 Da

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
Thiopeptide

Gene cluster description

nosiheptide (BGC0000610). Gene Cluster 1. Biosynthetic class = RiPP. GenBank FJ438820. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Detailed annotation

nosM leader / core peptide, putative Class I
MDAAHLSDLDIDALEISEFLDESRLEDS - EVVAKVMDhaADhaCDhbDhbCECCCDhaCDhaDha

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Homologous known gene clusters

Literature references

1. Yu Y et al. (2009) Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework. ACS Chem Biol 4(10):855-64.