LOCUS       BGC0000611             38587 bp    DNA     linear   BCT 22-MAR-2009
DEFINITION  Streptomyces sioyaensis strain ATCC 13989 siomycin biosynthesis gene
            cluster, complete sequence.
ACCESSION   BGC0000611
VERSION     BGC0000611
KEYWORDS    .
SOURCE      Streptomyces sioyaensis
  ORGANISM  Streptomyces sioyaensis
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 20:01:59
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 38587
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..38587
                     /clone="cosmid 3c7"
                     /culture_collection="ATCC:13989"
                     /db_xref="taxon:67364"
                     /isolation_source="soil"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sioyaensis"
                     /strain="ATCC 13989"
                     /type_material="type strain of Streptomyces sioyaensis"
     misc_feature    1..38587
                     /note="siomycin biosynthesis gene cluster"
     cand_cluster    1..38587
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /detection_rules="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /detection_rules="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /kind="neighbouring"
                     /product="terpene"
                     /product="thiopeptide"
                     /product="LAP"
                     /protoclusters="1"
                     /protoclusters="2"
                     /protoclusters="3"
                     /tool="antismash"
     subregion       1..38587
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000611"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..38587
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="True"
                     /product="terpene"
                     /product="thiopeptide"
                     /product="LAP"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /rules="((YcaO or TIGR03604) and ((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or PF07366 or PF06968 or PF04055) or thiostrepton)"
                     /rules="((((goadsporin_like or PF00881 or TIGR03605) and
                     (YcaO or TIGR03604)) or TIGR03882 or TIGR03603 or
                     TIGR03602) and not cyanobactin_synth)"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1..20465
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[9538:10465]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      9539..10465
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..20465
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     gene            complement(273..1448)
                     /gene="sio1"
     CDS             complement(273..1448)
                     /codon_start=1
                     /gene="sio1"
                     /note="predicted protein"
                     /product="Sio1"
                     /protein_id="ACN80632.1"
                     /transl_table=11
                     /translation="MTYRSYTLYAAVTQRQLARWVRLLTYAWRPHIPAQNGSCGTTSKF
                     LGLRRRNTYMRTRLRSSLVRTAAITAVASGAVIAPAASAMAADASSAPSSSASSSEAQA
                     KAEADAKAKANGNTHTNSEASAKAEADAKAKSNGNTHTNSEASAKAEADAKAKANGNTH
                     TNSEASAKAEADAKAKANGNTHTNSEASAKAEADAKANAKAEAGARTLVTTKTVSEAGA
                     SAHASANASASASANVSVKVYVDAHGQYAAELWSKDAKTGKTVKCGTIDKAGQTVTWKN
                     AKYTLHTDGSIVSTSAGGKTVTHQLTRSEANAASKAQVAAKAKARGSAVVPTSAGKQVS
                     QVPTGSVAAGYEQPAGNGSNGLIGVGSAAAAASAAGLGFVLKRRMGAGQAG"
     misc_feature    complement(1305..1307)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1924..3111
                     /gene="sio2"
     CDS             1924..3111
                     /codon_start=1
                     /gene="sio2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1104:putative esterase (Score: 179.5; E-value:
                     1.6e-54)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative esterase"
                     /product="Sio2"
                     /protein_id="ACN80633.1"
                     /transl_table=11
                     /translation="MSPGVPRGWAPSSVLARAARGGSEVENGGKHMKILSRAGLRGWGA
                     AFVGLVALLGMVGPAAPAAQAATAPPHFADGFGLTVVSQPKWAGPEKRTFVVTVKSRQV
                     PTYDAMKGQVPGEHVLMVTLPTGYNGAAATRYPVLYHLHGAGDLPNSLWTKTIAEHATK
                     GVPLITVSPNGGGHGWYANWRNPGPRGRQNWETFHLKQVIPFIDANLKTIAARAGRAIV
                     GHSMGGFGAIHYAEDRPDLFRYAGSFSADLDLRSPWGRGAVVGSGVVPAYGKPYAAPDA
                     IFGSPLWPLDGAWNAASPAHHVTALRGMGVAMYSGDGGNLLDNPVQAAVEKGAQVTTAT
                     MAAHLKSSGIPYRFVDYGDGSRWAKGCTGKHAQFPCLQADMNDYVKLIMKRLRHP"
     misc_feature    2041..2043
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3161..5605
                     /gene="sio3"
     CDS             3161..5605
                     /codon_start=1
                     /gene="sio3"
                     /note="XRE family transcriptional regulator"
                     /product="Sio3"
                     /protein_id="ACN80634.1"
                     /transl_table=11
                     /translation="MKRPSPATVALGAMVPVVRVLMPAGAVMVAGNGLVPARYVPWGRA
                     AVIALAVVLVVREVRRRRTGGAPAGRPAPRTGGTRNELNGITYGHALMADVISQVTFND
                     VRMPPTFKGTLDDAADRLAESVRKQWRDEEEQRKVQDPIPLPVRWQRASDELTDHWSNI
                     CLARPGTLPVPGPLPLAGQLHEIVDVYRRIPSARLVVLGRAGAGKSILTIRFVLDLLKA
                     RTASTEPVPVIFSLASWDPAMPLRRWLTGQLERDYPGLAVTGPGPGASTLAAELVERDR
                     ILPVLDGFDEIADGLHRRALERLNGHAAMHLLLTSRRDEYAAAVRNTKALTAAAVVELT
                     DLSPADLEHYLPRTARKTTATSTGWEPVLRSLRAHPQDPAGAPLAAVLTTPLMVALART
                     LYSDTPDRTPSELLETRFAAPEALEDHLLDNFIPTLYQDQPPARRARVLHWLGYLAQHL
                     DRLGTRDLARHPDRPGTRDLARHSDRPGTRDLAWWQLGHSLRRSSRRCVIGLVAGLALG
                     LVDGLVMWVLTWYAFGFGPVLGLMNGLVNGFSFASMSALAFGIVYGHRYGETACEPSRV
                     RVRLLGGAKEMRTEMRKEFVPRLAIGLVGGFGLGVLVWLMAALGFALVVAVRDSPGSAL
                     AAFLATRYDQGFNAALLYGLSAGLAYALMAGLEAPIDIETAASPPDLLHTNRTTALFHL
                     LVLALVLGTMGGVLYWTGWFSIASWVAFGLVGGLGGGLAYALSMTAWGQWVALSRIWLP
                     LTGRLPWNVTAFLADAHRRGVLRQAGAVYQFRHVRLQHHLTRASRTTSHGGADRVRAER
                     AG"
     protocluster    4382..38587
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[14381:37805]"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /neighbourhood="10000"
                     /product="thiopeptide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      14382..37805
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /neighbourhood="10000"
                     /product="thiopeptide"
                     /protocluster_number="2"
     cand_cluster    4382..38587
                     /candidate_cluster_number="3"
                     /contig_edge="True"
                     /detection_rules="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /detection_rules="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /kind="chemical_hybrid"
                     /product="thiopeptide"
                     /product="LAP"
                     /protoclusters="2"
                     /protoclusters="3"
                     /tool="antismash"
     gene            5846..6634
                     /gene="sio4"
     CDS             5846..6634
                     /codon_start=1
                     /gene="sio4"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 195.6; E-value:
                     1.7e-59)"
                     /gene_kind="transport"
                     /note="ABC transporter ATP-binding protein"
                     /product="Sio4"
                     /protein_id="ACN80635.1"
                     /transl_table=11
                     /translation="MSQAATTPTAPQAPAPAGAAACAVGLSKVYGEGETRVVALDSVSV
                     EFGRGRFTAIMGPSGSGKSTLMHCMAGLDTISAGSARIGDTELSRLHDRQLTRLRRDKI
                     GFIFQAFNLLPTLNALENITLPMDIAGRRPDQEWLDLVVATVGLSGRLRHRPSQLSGGQ
                     QQRVAVARALASRPEIIFADEPTGNLDSRSGAELLGFLRESVRELGQTVVMVTHDPVAA
                     SYADRVVFLADGRLIDELAGPTPEGVLDRMRRFDTKDRTS"
     gene            6711..9311
                     /gene="sio5"
     CDS             6711..9311
                     /codon_start=1
                     /gene="sio5"
                     /gene_functions="transport (smcogs) SMCOG1243:ABC
                     transporter, permease component (Score: 45; E-value:
                     1e-13)"
                     /gene_kind="transport"
                     /note="ABC transporter integral membrane protein"
                     /product="Sio5"
                     /protein_id="ACN80636.1"
                     /transl_table=11
                     /translation="MLRTALRNVLAHKARLMMTALAVLLGVAFVAGTLVFGDTTANAFR
                     TASAVSLKDVAVAVQAQMSEPESVPAGGPAKGGEGGSTTVLDAALAQKIRALPGVTAVR
                     PTINGEAVLADKDGRPVNADNPEKHLATNYQPGTAGKDSRFPLKEGRAPAAAGELALDA
                     KTAEKAGYRIGDTVRFATDGPALAKKLVGIVTTDDPRVAAGSTLALFDTTTAQKLFLSP
                     GRFHEIAVAARPGTDERALTARVQALLPADGATATSGADLAAQQSAQITADTQFLTKLL
                     LAFAGIALFVGVFIIANTFTMLVAQRSREIALMRAVGASRRQVVRSVLIEAALVGLGAS
                     AAGFALGLGIAAALRPLLNAGGAGLPDGPLVVSPQAVLSSLAVGVVVTVLAAWLPSRKA
                     AKVAPVEVLSSAGVAPPARTLRVRNVLGALLTGLGILVMGYVCTLDTTDKSNLLIAMLG
                     SVLTLNGVIVLAPLLSRPLITLAGEVTTRFFGVSGKLARENALRNPRRTAATASALMIG
                     LTLITGLTVGGYSTQQAMDEEAAHGTTADFQISNSNHTGFVPTDAAKVAKVPGVATAAP
                     LTVGNFQARGQHAGIAGTDPAAFAKVTDLTFREGSLAGIRAGTVAVSDEFAQKTGAGVG
                     DTLDAATDPMEPGKHPTTKKLKIVAVYEANPAVTQALGTLHDVLPYSATHTLDGIMVKA
                     EPGKAGSLEHDIRAALGNSPLLKVQNTEQITKEARKNLTTALNMIYGLLGMAVVIAVLG
                     VINTLALSVIERTREIGMLRAIGLDRAGIKQMVRLESVVISLFGALLGIGTGTFLAWAG
                     GHLMTSSVATYETVLPWAKLGLFLALALLIGVLAAIWPARTAARLNMLQSIQAH"
     gene            9539..10465
                     /gene="sio6"
     CDS             9539..10465
                     /codon_start=1
                     /gene="sio6"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /note="phytoene synthase"
                     /product="Sio6"
                     /protein_id="ACN80637.1"
                     /sec_met_domain="phytoene_synt (E-value: 2.6e-24, bitscore:
                     76.7, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWTTRLDAAGIHDPQLREDFTRQRALVAGYKRAAYIAVLLLLPRP
                     LAPHMIAATAFMHHTDNLLDHGPLPQRAAAYAAWEEEVNQAIATGTSDHPVIRPLLHTG
                     ARHPRLLGHVKDFLRTAATDLEFTGFATESDYQRYLDAYSLPAFMLVAGLLVPGDEPAG
                     YRAACRTYIDGSQRLDFVNDLAEDLAEDRLTVPQDTLVSHGVTRTDLVDAQDTPEVRAL
                     LRHLLHQARADLAASHRVIELLPAANRPFARALIALEKATVDAAGAKGPGLLTSAARPA
                     VPALLTILTREYRHARRLRRSRAEGSE"
     gene            complement(10491..11552)
                     /gene="sioA"
     CDS             complement(10491..11552)
                     /NRPS_PKS="Domain: Aminotran_1_2 (40-334). E-value:
                     9.1e-51. Score: 164.9. Matches aSDomain:
                     nrpspksdomains_sioA_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="sioA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 145.3; E-value:
                     4.1e-44)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative aminotransferase"
                     /product="SioA"
                     /protein_id="ACN80638.1"
                     /transl_table=11
                     /translation="MTRAAGPAHPGAPTHPGEGHQLSLNEMPAVPLAHLEEVLRESLLG
                     ANRYPDPFSRRLTEAIADLYSVPDHEVVVGPGSAAILQHVIQWAAPQPTDEVIYARPSF
                     DAYRLVVNAAGAKPVEVPLKEHKHDLSRMLDGITPHTRALVLCNPHNPTGTALDTAGML
                     AFLREVPEHVVIVLDEAYREFAGGQDTLNGPEAYHDIPNMVVLRSFSKAYGLAGLRVGY
                     ALAPRDIAHTLRNRLLPFSVSTIAEAAARAALARRPEVLRQVDRVIAERGRLTEGLRHQ
                     GWDVTPSAANFCWLPLGPRSPAFAAAAARQGILVRAVGEEGVRITVGEPQATDALLHFT
                     AQFAAESAGLASA"
     aSDomain        complement(10551..11432)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sioA_Aminotran_1_2.1"
                     /evalue="9.10E-51"
                     /label="sioA_Aminotran_1_2.1"
                     /locus_tag="sioA"
                     /protein_end="334"
                     /protein_start="40"
                     /score="164.9"
                     /tool="antismash"
                     /translation="ESLLGANRYPDPFSRRLTEAIADLYSVPDHEVVVGPGSAAILQHV
                     IQWAAPQPTDEVIYARPSFDAYRLVVNAAGAKPVEVPLKEHKHDLSRMLDGITPHTRAL
                     VLCNPHNPTGTALDTAGMLAFLREVPEHVVIVLDEAYREFAGGQDTLNGPEAYHDIPNM
                     VVLRSFSKAYGLAGLRVGYALAPRDIAHTLRNRLLPFSVSTIAEAAARAALARRPEVLR
                     QVDRVIAERGRLTEGLRHQGWDVTPSAANFCWLPLGPRSPAFAAAAARQGILVRAVGEE
                     GVRITVGEPQATD"
     gene            complement(11597..12421)
                     /gene="sioB"
     CDS             complement(11597..12421)
                     /NRPS_PKS="Domain: Thioesterase (29-148). E-value: 9.7e-09.
                     Score: 27.8. Matches aSDomain:
                     nrpspksdomains_sioB_Thioesterase.1"
                     /codon_start=1
                     /gene="sioB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262:haloalkane dehalogenase (Score: 57.8; E-value:
                     1.7e-17)"
                     /gene_kind="biosynthetic-additional"
                     /note="alpha/beta hydrolase fold"
                     /product="SioB"
                     /protein_id="ACN80639.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4e-16, bitscore:
                     51.1, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 4.4e-19, bitscore: 59.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEVTARRFTGVRHPIHTHIWPHPTPRYLAIFVHGYADHAGRYGH
                     LASALNRHGAAVYAPDHMGSGRSDGQRALVTDYDELVADVGTVLEQARGDHPGLPVVMI
                     GHSIGGMVAARYAQRRPDDLSALVLVAPVLGSWHTATSLLAFDEIPEMPMDVGSVMSRD
                     PAEAARYNEDPLIWHGAFVRRTLESVVTCLDRINDGGGLSFLPTLWLHGDADPLAQLEE
                     TRSGIERLRGFHLTERVYDGALHGIFHDSDQDRALADTTAFLDDALKVPTHP"
     aSDomain        complement(11978..12334)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sioB_Thioesterase.1"
                     /evalue="9.70E-09"
                     /label="sioB_Thioesterase.1"
                     /locus_tag="sioB"
                     /protein_end="148"
                     /protein_start="29"
                     /score="27.8"
                     /tool="antismash"
                     /translation="AIFVHGYADHAGRYGHLASALNRHGAAVYAPDHMGSGRSDGQRAL
                     VTDYDELVADVGTVLEQARGDHPGLPVVMIGHSIGGMVAARYAQRRPDDLSALVLVAPV
                     LGSWHTATSLLAFDE"
     CDS_motif       complement(12077..12124)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sioB_0001"
                     /evalue="2.60E-05"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="sioB"
                     /protein_end="115"
                     /protein_start="99"
                     /score="16.1"
                     /tool="antismash"
                     /translation="PVVMIGHSIGGMVAAR"
     gene            complement(12500..14359)
                     /gene="sioC"
     CDS             complement(12500..14359)
                     /codon_start=1
                     /gene="sioC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177:asparagine synthase (glutamine-hydrolyzing)
                     (Score: 635.8; E-value: 1.2e-192)"
                     /gene_kind="biosynthetic-additional"
                     /note="asparagine synthase"
                     /product="SioC"
                     /protein_id="ACN80640.1"
                     /sec_met_domain="Asn_synthase (E-value: 3.8e-90, bitscore:
                     293.8, seeds: 78, tool: rule-based-clusters)"
                     /sec_met_domain="GATase_7 (E-value: 3.9e-46, bitscore:
                     146.9, seeds: 307, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCGIAGWVAFERDPGAERSAVQAMTDTMACRGPDAEGVWYGSHVA
                     LGHRRLAVIDLAGGTQPMTAEEDGEVAAVISYSGEVYDFAALRNRLRGAGHSFRTDSDT
                     EVVLRAYLEWGTDFTRHLTGMFAFALWDTRSRELLLVRDRLGIKPLYYYPTSDGVLFGS
                     EPKAILAHPEARARLSPAGLRELMTWVNTPGHAIFDGMSQVRPGHLVRVSRGNLTETAY
                     WQLPARPHDDDFDTTVGRVRALLQAAVAGQTVADVPLCSLLSGGLDSSSVAALAAEALR
                     PSGQPPLQCFSVGFAPSGHAAMPVSDGSALTDDADYAAKLAGHIGAHHESIVLDAKLLS
                     DPAARAAVLRARDLPQGLADMDTSLYLLFKAIRQRSTVALSGEGADELFGGYPWFHDEQ
                     ATRARTFPWMYAAGAGAAQGPAFLDPALPERLSLDEYRADSYADAIAAVPVLPGEPEPD
                     RRMRTVNHLFLTRFLPMLLERKDRMSMAVGLEVRVPFCDHSLVEYVFNVPWSMKSFDGR
                     EKSLLRAAMAPDLPESVLTRKKEPYPTIADPAYDQLLKGRLGDLMDDAGAPVRALMDEK
                     SAAKAFDTVRKASPGELRFLRVGFESLIKINDWMRDYQVELAE"
     protocluster    14303..38587
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[24302:29616]"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="3"
                     /tool="antismash"
     proto_core      24303..29616
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="3"
     gene            complement(14382..14789)
                     /gene="sioD"
     CDS             complement(14382..14789)
                     /codon_start=1
                     /gene="sioD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: PF07366"
                     /gene_kind="biosynthetic"
                     /note="ester cyclase-like"
                     /product="SioD"
                     /protein_id="ACN80641.1"
                     /sec_met_domain="PF07366 (E-value: 1.6e-33, bitscore:
                     106.1, seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDREAALHLMEHFLAAYNEGNPKHLDRCLHPDYRHPNPAVERGIE
                     GMRGAVRRWAASVEDLRLTLDDLVVEGDKVVARMTFSGRQVGTILDIPPSGKHFSVGLI
                     DIFLVEDGLFAQHWDEMDLLGLHRQLGALPA"
     gene            complement(14834..16066)
                     /gene="sioE"
     CDS             complement(14834..16066)
                     /codon_start=1
                     /gene="sioE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1191:acyl-CoA dehydrogenase type 2 (Score: 194.2;
                     E-value: 5e-59)"
                     /gene_kind="biosynthetic-additional"
                     /note="acyl-CoA dehydrogenase domain-containing protein"
                     /product="SioE"
                     /protein_id="ACN80642.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 6.8e-16, bitscore:
                     49.8, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 9.9e-12, bitscore:
                     36.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPLITQPTRQRYVAMAEELAAAFRERAAEYDRKAEFPHQNIDEL
                     RDAGYLALTVPQELGGLGGTLGDMALTQERLAAGCASTALAVNMHLSMAGQMARNWRTT
                     GDERARRTLRDIVDGRVILMGATAEPGHALVRSTGAKARKVDGGYLVTGDKTFGTGSAV
                     MTHMTSMAEYREHPDGPQVLVFRIPADSPGVRVLDGTWNTSALRATRSENIELRDVMVP
                     EENVLTSFPVGTLDGSLLQTVWGWAMPTFAAVYLGVAVGAFEQCVRDVLSRGWDDRPYI
                     RAEISECEALIETSRALIERTTREVMGNGLWTELSIQHGTARVVLAKTVGTNHAVEVVD
                     RVIRIIGTPALRPGSVYERAHRDVRAGTMHPYSNADACDLIAATTLGAEVAPTHPPRLD
                     RLAEPAPDGNP"
     gene            complement(16090..16974)
                     /gene="sioF"
     CDS             complement(16090..16974)
                     /codon_start=1
                     /gene="sioF"
                     /note="putative methyltransferase"
                     /product="SioF"
                     /protein_id="ACN80643.1"
                     /transl_table=11
                     /translation="MPGAPPPGSGEKSTMSSLIETAHWIACARAAESLRDDRLFHDPLA
                     VEFVRRTEPDLYARLRSEPSSRYDVLAVRTRFFDDCLLRAVTTGPARQVVVLAAGMDGR
                     AFRLPWPPGVTLYEVDLPAAVEEKAAFLSRTSLTADRCHRIAVGADLTDDWPSALVDAG
                     FRSDLRTAWLAEGVLYYLTEHQVNAVVDRVTALSAAGSACFLEHVNTDLYRAPWMQEWL
                     RTMRDEGRPWLSGVADPETWLGGRGWQAVVREPGELAEAAGRLVPRTPPRATPGAARTW
                     LISADLADPAPSG"
     gene            complement(17000..17554)
                     /gene="sioG"
     CDS             complement(17000..17554)
                     /codon_start=1
                     /gene="sioG"
                     /note="hypothetical protein"
                     /product="SioG"
                     /protein_id="ACN80644.1"
                     /transl_table=11
                     /translation="MEVASCSIPDDTALACFRDSGEYTHAEAAESLIPDQEKVDARELA
                     RLAMDRPSLTPERAFWLIDLWIRVQALVLRPFGVKPNTMRSTRDQPLPTVGERLGPYEV
                     FEASEREVLLGDTDKLLEHRMSFIVADGKAYIGVVLRTRNKAGEDYWNQFRHNQTEILH
                     WSLRRGLSRALGDDDIAAQAR"
     misc_feature    complement(17459..17461)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17889..18074
                     /gene="sioH"
     CDS             17889..18074
                     /codon_start=1
                     /gene="sioH"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: thiostrepton"
                     /gene_functions="biosynthetic-additional (thiopeptides)
                     predicted thiopeptide"
                     /gene_kind="biosynthetic"
                     /note="propeptide"
                     /product="SioH"
                     /protein_id="ACN80645.1"
                     /sec_met_domain="thiostrepton (E-value: 2.4e-39, bitscore:
                     124.2, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAAIVGQEIGVDGLTGLDVDALEISDYMDETLLDGEDLSVTMV
                     SSASCTTCICTCSCSS"
     CDS_motif       17889..18020
                     /prepeptide="leader"
                     /note="peptide class: thiopeptide"
                     /note="predicted sequence:
                     MSTAAIVGQEIGVDGLTGLDVDALEISDYMDETLLDGEDLSVTM"
                     /locus_tag="sioH_thiopeptide"
                     /aSTool="thiopeptides"
                     /tool="antismash"
     CDS_motif       18021..18074
                     /prepeptide="core"
                     /locus_tag="sioH_thiopeptide"
                     /peptide="thiopeptide"
                     /predicted_class="Type II"
                     /score="21.40"
                     /molecular_weight="1642.9"
                     /monoisotopic_mass="1641.6"
                     /core_sequence="VSSASCTTCICTCSCSS"
                     /aSTool="thiopeptides"
                     /tool="antismash"
                     /leader_sequence="MSTAAIVGQEIGVDGLTGLDVDALEISDYMDETLLDGEDLS
                     VTM"
                     /leader_location="[17888:18020](+)"
                     /alternative_weights="1660.9"
                     /alternative_weights="1678.9"
                     /alternative_weights="1696.9"
                     /alternative_weights="1715.0"
                     /alternative_weights="1733.0"
                     /alternative_weights="1751.0"
                     /alternative_weights="1769.0"
                     /alternative_weights="1787.0"
                     /alternative_weights="1805.1"
     gene            18770..19555
                     /gene="sioI"
     CDS             18770..19555
                     /codon_start=1
                     /gene="sioI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /note="putative hydrolase"
                     /product="SioI"
                     /protein_id="ACN80646.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.4e-14, bitscore:
                     46.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPVILVHGLLGTEDAHYAGCRRWWRHSVTEIRLPGHGAGGEVPS
                     HPAAAAIDRLREAIGEQPQPPVVVGLSYLGAAVAFRAAESAPDRVAGVVMSGYSFLVSP
                     DTLNRWLAGFTRMATHQQGSRNHFAELHGEKWEKLLTATFDELSDGCLRLPDVEDLTRV
                     GTPVQLVNGALLQNERNAIGPAAAAGADVAVVAGAGHVVPVDAPRVFAATVEEFAARVD
                     AGRTAFHERRRAAERAADVAAGEAGKAGEAAEAGEAAHV"
     gene            19548..22196
                     /gene="sioJ"
     CDS             19548..22196
                     /codon_start=1
                     /gene="sioJ"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     37.2; E-value: 1.2e-11)"
                     /gene_kind="biosynthetic"
                     /note="dehydrotase"
                     /product="SioJ"
                     /protein_id="ACN80647.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 8.3e-27, bitscore:
                     84.2, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRPGIRYAGYGVVRVCSQPVDVVAQLSSREVARLCDELRELRRD
                     WQDRAPRVAEELTSLVPDLTDREQRRAVLALRRRLHRAADVPAAALDVLHLPGGADVAG
                     AAELRALAAARDDLTARWEDAYEAALRAEQKVLASAALDRSLRAGAQLSADGLLHNMDR
                     YAAAVADGTAHGKRDRMTESTVLNLLTRSALKPSPFGQLVRTQPVLLQERAAAEAPSAE
                     LDADAQVSVCRLPRQLVSWVERSLADHPAFRSAAVLRRAPVVGSSSEGVVFLLRGRDGT
                     HEPAAKERLVRVPSSTVVTELLALSADLAVPERDVRARCAALPDTDPAAAHTALDTLIE
                     QGVLARDLGVGDQHPHPIARLVALLPQDCDAGLRECVDRMAAAESAFETAGLDRREELI
                     AQIKRQVAEVADRCGVATPPIEAARTLLYEDTVVATPRTEPADRWQRHLPALSHWHRLL
                     PLFDDAAHVRAIVADVVRTRFGPGPHRLLTLFAALSSAKVQLLLTQRLTDVSAPMPTQL
                     RTLQDAVYELARPEDGAETVIDPQRAAELAENLPPWIPRWSRASWSVQHDASPDGGLLV
                     VNGGSIGFGRAISRFLPSYAAVGDGGFGELVRAEIAQDDRTSAPLTDLSAVLGINANVH
                     SPLLGSYLRYPCATPEEWGQDPGVSLEECWVECDEGTGRLLLRRGKDGPPLRLVMLNFL
                     LNELAPRFYQFLNFFGAGSLANLAWWDRVDQRRGDPHTVRRYPRVRSGSLVLARRTWKV
                     PADRLPDVATGNGADAFAEVRRWQESLGLPDRVFYRGFTLPDPLVPTSEEEQHTWARTL
                     ARFPTSAERKPTFLDFTSVTSVRAWQRALRRCQGDLTFQECLPTVGDDGAQGHRERLTE
                     EFIIETTEGAR"
     misc_feature    20637..20639
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            22193..23197
                     /gene="sioK"
     CDS             22193..23197
                     /codon_start=1
                     /gene="sioK"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /note="dehydrotase"
                     /product="SioK"
                     /protein_id="ACN80648.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.6e-67, bitscore:
                     219.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTDTAHSWLSCHVFHHGDTDPLLTDLLLPMVDELRGAGRLERHF
                     YLRHWERGPHVRLRMQVPAEQHDDVRAQVERRIVDHLERHPGPADTDPVRLRDALRHLS
                     ELEHGDASDALMQTPEPPNTVRWIDYRPETAKYGGPEGVEIAEDVFHASSLLTGQVLRL
                     VRNDRARLGISLQLLLLASRALGFGPDDRALFLRTYHERWAAYVSDDRLLAAWNEQYRL
                     QRADYAKLIAGLDTGEPIGKGLGERWERTLVQSLERLRPLVAAGRVWPAETDRSAPPVV
                     ALATLVSQYLHTTNNRMNVRPQGECFVAYLACRAAEEQGASQSRPVPAAQRQG"
     gene            23194..24306
                     /gene="sioL"
     CDS             23194..24306
                     /codon_start=1
                     /gene="sioL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /note="hypothetical protein"
                     /product="SioL"
                     /protein_id="ACN80649.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.5e-26, bitscore:
                     82.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAMSSSEQKDLTVSVPWSVQEDLLLDVAAPTLEESVALGETESW
                     FYLRENYGGRPFLRLRFATRSPSVERRLKSRIMEHIGSAASDDPFEHQPYNHEHDWLGG
                     EAGLGLAEAFWTETTPLALRTLRATRGDRALRLAAAFDFLVCSGVLLAPHLPPPVAKFG
                     FKAGYLSYLATFEGYMLLIRDPEGTRAKHAQRYEQNRNLLRPRLRALVEQMQDPEGDLA
                     DVPELAREWAVRLRGYLPAIRKGFDEGRFYLYATPRKAETAKLTPSPDGLYRRPKVEWL
                     ADLPEAPVAGIHRAIADNTYYQGMIREDRRFLASRLAQAYTNWHLYRLGFLLADRYTLF
                     YLIARAFEEEYDLDAAELIRSVQPEAEVSG"
     gene            24303..25967
                     /gene="sioM"
     CDS             24303..25967
                     /codon_start=1
                     /gene="sioM"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_kind="biosynthetic"
                     /note="NADH oxidase"
                     /product="SioM"
                     /protein_id="ACN80650.1"
                     /sec_met_domain="PF00881 (E-value: 5e-09, bitscore: 27.3,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAADTGAPPLSGDPSERGPFDDAGVDAFVRRLRGSYEEVHPQHW
                     QIDWRNIPSPFRWYADLPRRDLPTMSRTVAAGGPAAAAAFAASDPATRLGALLQAGYGL
                     TGVRWYPAGIAKSSPEEPTPVHRNPHYQLRRAMPSGGVTYPAECYVVTAGTAGLDAGIH
                     HYDAVRHALAVLSRGRPPAELTPPAGGVRIVLTQPLWKNYFKYGDFSYRLGAMDTGAVV
                     GQFALAARSWNLPARVAFGVDERRIADLLGLDPEEEATPAVVDIALGDPAEAERGPAAG
                     RAAPVGRPRWLGASAPPGPTTGTRRMHAACLAAGRPGRTVDLPPVVLEDLADRADAELP
                     AVSGRPVSVADSWARSALGEQLRGAPLPADVLADWLPQVLAPLDCDVTGSGDVPALTHP
                     RCVLVVRSVPGVPPGAYLPQQDGRRLARLADGDFGPVVQRSMFAHYMNVGQAPLIAVMV
                     GATEPHRGASGPVGYRTQHLLAGVLAQRLAVCAARDGRSAHPVLGFVSGVLDEALGLGA
                     RRLTSLLMVPVGGYRRGLYLENSLSPLAAAAGDGGGI"
     gene            25964..27676
                     /gene="sioN"
     CDS             25964..27676
                     /codon_start=1
                     /gene="sioN"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Thiopeptide_F_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Heterocycloanthracin_C_RRE"
                     /gene_kind="biosynthetic"
                     /note="hypothetical protein"
                     /product="SioN"
                     /protein_id="ACN80651.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 5e-32,
                     bitscore: 100.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     2e-10, bitscore: 31.3, seeds: 5, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGTVLRLRADAYYVPVPNGVWIRTTDGSFTLNGKTVATWVEKLA
                     PLLDRGVVPDELLGALKPEQAAFVDKLLKALEQRKVLRPEPADEGADDPESARLFPQQA
                     EYLRHFTARPAEGFARVRRHPLAVAGPAERVGPLATTLMETGFGDLVLLDTAPGKELQE
                     LAEDFGRQGAPVRLSGPDGDLEGRTVIGVFAPGEEEDAWRLLDRAEALGSGAWAALVRG
                     QAMLLKGQVPRSGRACVRCAWRRLAHQAVELPPSDGLGYVPVSVAATVLAQEVFQYVAG
                     GDDAVLGEGVVVDLTRLSIWRTDVDPDPDCPGHALPAGPADPSLAPAAGRRTRFPDSVF
                     GARCFGPLFSCTPEQLPQFPLTALRLRINPPGRGEPTGSADGPVIVAESVADARAEAAV
                     TAVEATLPTSGDTVVGVGKDRAEAGARALLRWADAALDDAAPDDAGAERREGTARSERA
                     RALAELAGRDVELSTARHPSGLWRARVDGTVTRTGFDPDQAVERALLAALARGQLGHGD
                     DATAVTAWTGTVPEERRVDEVASALGLAWREAALPPLVAADLTGIVLAPGHAG"
     gene            27673..29616
                     /gene="sioO"
     CDS             27673..29616
                     /codon_start=1
                     /gene="sioO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_kind="biosynthetic"
                     /note="cyclodehydrotase"
                     /product="SioO"
                     /protein_id="ACN80652.1"
                     /sec_met_domain="TIGR03604 (E-value: 1.4e-84, bitscore:
                     274.8, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 6.6e-68, bitscore: 220.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSETLTSRRRAPRLPDDPAAELRRWVGDAVDVRTADGMPAAGDGR
                     PVVVVHLDWDADLSDLPAADTVVVPVYGLRGRVVVGPVMRPGQPGCPHCLALRVRAADG
                     PEGVPAGAEAAPRRLSARRAGWLPPGALRLVAAVVRDEAERLAAGVPPRGVDAAFAVGP
                     ARLTGDWHPALPHTLCTAPHCLGSRRPLPPPVPDLSRPLPTTGVGSARRVPAARYADRL
                     EQEYLDAWSGLTRSAAVGDRAALPSTQVRVPTVWGFDEIAIGRAEDYAGARPAAILEGL
                     ERYAGWHCGGRDPVRFAAFAELDDAVDPRSLLLHPDEAYRQPGFEYTPFTPDTRTGWAQ
                     AYSAHTGRPALVPFHVAYYGATRRPDTGPRFVYENSNGCALGSGVEEALLAALLEVAER
                     DAFLCAWYSGTPLPEIDLGGLTGEAARAVRTVRHRTGRDLRAFRALGAFDVPVALLVTT
                     SPDPERPATLVTAGSGLTVERALLGAVHEMAAAAPVITVEYQRRRPELERALDAPDLVR
                     RMEDHALVGALPGARPRFSFLLDGTPPDPSPAVTPAPPAGDVAADLAAMLAAARRDGQE
                     VFVVDHTTGELDRLGLSCVKAIVPGTVPMTFGHRHRRLPPPETLQAFRARNGIGPVEFP
                     IEEVRHEPHPFP"
     gene            29594..30943
                     /gene="sioP"
     CDS             29594..30943
                     /codon_start=1
                     /gene="sioP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 144; E-value: 1e-43)"
                     /gene_kind="biosynthetic-additional"
                     /note="cytochrome P450-like enzyme"
                     /product="SioP"
                     /protein_id="ACN80653.1"
                     /transl_table=11
                     /translation="MSRTHSPETAAPAAPAATPEGLSPLPNGLGWVVSSRSLTVRLLGD
                     HRLGVLEPQPVMAHLVTKLPDELHPQVDEIAAFAERVMLQTGPARHQVLRRAFGGFFDA
                     DAIEALTPELRRGAEDTVRRFAASGGGEFMTAVAFPYAVRVGARLIGFTDDDYRRLHKL
                     SQQVALVAYAARLDDPAEAVRAGHAALVRVREIVAAARAAAPPASVLGAWHAGTLDLSD
                     EDIEANAVMLVQASLETVSGMLGNAAVRILGTPGALADAASRESLLDEALRAEPPLKTL
                     ERVVREPFQLDGHEFRSGQVISVRVADANRLDDDPVAGRALFSFGWGAYRCLGARLARH
                     QARELFQALHHLAPDAAPADAEIERVRHIRFDMPRRLRVVCSPPAADGASLTRALTDAL
                     EEEDLDRPLTSLEREVTYVVLKENGVLVPEDLRGPTTIREWVTWALSEHG"
     gene            30919..32220
                     /gene="sioQ"
     CDS             30919..32220
                     /NRPS_PKS="Domain: AMP-binding (110-350). E-value: 4.8e-22.
                     Score: 69.9. Matches aSDomain:
                     nrpspksdomains_sioQ_AMP-binding.1"
                     /codon_start=1
                     /gene="sioQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     102.9; E-value: 2.5e-31)"
                     /gene_kind="biosynthetic-additional"
                     /note="acyl-CoA synthetase"
                     /product="SioQ"
                     /protein_id="ACN80654.1"
                     /sec_met_domain="AMP-binding (E-value: 2e-25, bitscore:
                     79.9, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGALGAWLTQAAPVLRGSRAGVVTERGRFSWPSLLARAEELVAEL
                     PDAPHGWVVPSDGGERSIVGLLALGLLDPAPRWVLGDPARWGAAGHAPVGDGALLAAGP
                     QAAPPPGVDGPTYATASSGTTGRPKLLFGRPHAVASAVELYVDGLPEYASAEVFATCSA
                     IDFAAAFYMVVAPAMMLGRDLVLFRPSGWETAIPELAGRPGVCLAPPALTVLGARTAAG
                     QRAFSHTCFVPAGGGLTPERAERISTGFPGSGFLTMLGSTETGLVTVDRAVHDDGYVGA
                     PLPGKPVWLEDIGPDGVGTLWTRGPDTRFAVTGGRLTTRPDGAVTTGDLAHPADGGFVL
                     DGRKDDLVKVDGVSVYPRQITAAVRALPGVTDASVAVDRSRTGDRLTVIAVGDVTEARV
                     RDACRRLPAPVTPHQVVCRPADEAAYDARGKVLR"
     aSDomain        31249..31968
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sioQ_AMP-binding.1"
                     /evalue="4.80E-22"
                     /label="sioQ_AMP-binding.1"
                     /locus_tag="sioQ"
                     /protein_end="350"
                     /protein_start="110"
                     /score="69.9"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="GVDGPTYATASSGTTGRPKLLFGRPHAVASAVELYVDGLPEYASA
                     EVFATCSAIDFAAAFYMVVAPAMMLGRDLVLFRPSGWETAIPELAGRPGVCLAPPALTV
                     LGARTAAGQRAFSHTCFVPAGGGLTPERAERISTGFPGSGFLTMLGSTETGLVTVDRAV
                     HDDGYVGAPLPGKPVWLEDIGPDGVGTLWTRGPDTRFAVTGGRLTTRPDGAVTTGDLAH
                     PADGGFVLDGRKDDLVKV"
     CDS_motif       31942..31998
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sioQ_0001"
                     /evalue="2.90E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="sioQ"
                     /protein_end="360"
                     /protein_start="341"
                     /score="13.6"
                     /tool="antismash"
                     /translation="GRKDDLVKVDGVSVYPRQI"
     gene            32192..33424
                     /gene="sioR"
     CDS             32192..33424
                     /codon_start=1
                     /gene="sioR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 249.8; E-value: 7.5e-76)"
                     /gene_kind="biosynthetic-additional"
                     /note="cytochrome P450"
                     /product="SioR"
                     /protein_id="ACN80655.1"
                     /sec_met_domain="p450 (E-value: 8.1e-10, bitscore: 28.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHAARCFAEKERDGMTTGPTRAAVTEALLRCPAPLYARMHRQGP
                     LVWSRPDRTWVVTGYDLARLVLRDPRFRLPGPPPESEWSENGSHAGFFQSMLLASEGER
                     HARLRRFLGRLFTPRAVRARTVRIEAAMAALLDDAGRCPTMDGVAGISARLPVSVIGDL
                     VGIPEDDRHEVSELCRVISRGGGVASGRPSGDDVGNALARVDDLGRLVQRWRATPDRLM
                     PDSVLALAVDARDTSEALSDTEVLANVFSLYIAGHDTSRNMLSGLLLRLATHPELLAGL
                     SAGEVDTSAEVDRLLLGESPLTFTVRVAQEECTLEGERIRPGDMIRVMLGAANHELLTS
                     GAQADHAGVSFGEGRHVCLGAHLARTEGRVLLEAVGRRWSGLRLAAEPAWTPHFLHRGL
                     DSLPLEIEWRQ"
     misc_feature    32390..32392
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            33412..36018
                     /gene="sioS"
     CDS             33412..36018
                     /codon_start=1
                     /gene="sioS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     36; E-value: 2.9e-11)"
                     /gene_kind="biosynthetic"
                     /note="dehydrotase"
                     /product="SioS"
                     /protein_id="ACN80656.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.5e-27, bitscore:
                     85.5, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAVSGNDAPPPTDRVTLGPVAVRRRCRLPGSVVVDLGSDGVWQA
                     AGAWAAAEDAAHRRGAVLADHLGTLVPTVRQEQRRDVLRARRAAFNARPLPAGLPVDAA
                     TADRIAAYTRTLASRDTSERELGLALGKLAETAGATVDAALREEDIAWSVELSVPGLLA
                     AGPVGVLDATAGKKARRRALTLLRLVHRAATKPTPFAGFATTDVLFRGAATTPPRTHVR
                     VDRAVVEWVRQWIATGGYRSLRPELLWLTVNPSAAVREHPDGLRVTWLVNAANGTERVR
                     SARCGAALAGTLHQLRDPVRLDTVAPGGALPDTLARLIERGLLEAGPRLPSHGRRTLCA
                     VAGATVPAPGAEGEEARRAQDVHDALCALRDAEDALATAGAARTAALRGAKEGIAALAH
                     TLGTGVRAADRATVSADVVGVRADDGILRTSPEVLADLGRVQRIVPLLGFELPFQLATG
                     IAFRRRFGSDPVPVPTAYAWFLDAGRKEADALLADCAAEELAAVLALRQRLFDGLRAAA
                     DRPGAEVSCDPGLLDAVAAGLPDAVMDLPCAAWPVQLAGDHVVVNGVGTGYGRFAARVA
                     ADLDASRIAELRAWAARADTPQEGGIPVDVSALLGATVNEHPLLLPAALSYPGRALECD
                     PEARIDLSACVAQAVGGRMLLFSDRFPGRPLFPVPHNSTLATVAPGLYRWLSRFGPASG
                     ATLTLWDHVDALAAPESSATVRHYPRLTLGHLVLSRRTWKVPGAALPGGTWAGTAQGAL
                     AWHRWCARTGVPRRSFLRTTTLPDPWDVVRGRADKSPVMAARSASGAGIRKPLYVDLSQ
                     PLCWPAAAVAPGDTLTFTEPLPDPIDADPDGRVTEYVLETSQPPRVSTAGGAGARP"
     gene            36030..37805
                     /gene="sioT"
     CDS             36030..37805
                     /codon_start=1
                     /gene="sioT"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: PF04055"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 140.4; E-value: 1.2e-42)"
                     /gene_kind="biosynthetic"
                     /note="radical SAM domain-containing protein"
                     /product="SioT"
                     /protein_id="ACN80657.1"
                     /sec_met_domain="PF04055 (E-value: 8.4e-15, bitscore: 46.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAHKGIITLINPNQIYPPIAPYALDVLTTALEAEGFETHVLDLTF
                     HVGDWKQALRDYFDSSRPLLVGVTCRNTDTVYAFEQRPFIDGYKAVIDEVRGLTAAPVI
                     AGGVGFSTMPFALVDYFDVDFGVKGPGEKIICDLAQAFVEGRTADHIPGLLINRGPGQV
                     TRVPPPVLNGRAAAAPAPVAAPAPLPAPAPLSFGAVGRYESRAWQAETERSYTRRSGEP
                     YKIDNLRYYREGGLGSILTKSGCVYKCSHCVEPDAKGTQFARRGVAAVVDEMESLTAQG
                     IYDLHTTDSEFNLSISHSKSLLREIIRRREGDPASPLRHLRLWVYCQPAPFDEEFAELL
                     AAAGCAGVNVGADHVRPEMLDAWKVTGKGTRYYDFSDTVRLVELSHRYGMLTMVEALFG
                     MPGENLSTMRECVDRMMALDATVTGFSLGLRLFPYMDLAISLAEKCDGVRTLPGLQSNN
                     ATRPIVLKPLRKCSSPIEYERQFMFDESGEFRLVCYFSPDLPEAPGTVGSPHGIWQASV
                     DFLWDHIPKSEYYRVMLPTISGSSENDNNYADNPFLTSLNRQGYTGAFWAHWRDREAIM
                     SGTGALGELAVEAAR"
     gene            37802..38569
                     /gene="sioU"
     CDS             37802..38569
                     /NRPS_PKS="Domain: PKS_KR (12-174). E-value: 2.3e-14.
                     Score: 45.5. Matches aSDomain:
                     nrpspksdomains_sioU_PKS_KR.1"
                     /codon_start=1
                     /gene="sioU"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     184.1; E-value: 5.5e-56)"
                     /gene_kind="biosynthetic-additional"
                     /note="short-chain dehydrogenase/reductase"
                     /product="SioU"
                     /protein_id="ACN80658.1"
                     /sec_met_domain="adh_short (E-value: 8.9e-33, bitscore:
                     104.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAELPSLRGQAALITGAGRGLGSILAAGLAEAGMAVGLIGRNRR
                     RLDDTARACARHGAATAVCVADVRSPREIREAARAVHAELGPVDLLVNNAGLVDQGEAP
                     FWEADPEHWWEVFETNVRGTVNACQAVGQEMIRRRSGRIVNVNSIFAVQGDLRYSAYSG
                     SKASLLALAAVVADPLRDHGVHLFDISPGMVRTDMTLSMAVCAGREDWTDPARFVAAVL
                     RVARGELDPLAGRFLHVGTDDLDELLGRQQLTG"
     aSDomain        37838..38323
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sioU_PKS_KR.1"
                     /evalue="2.30E-14"
                     /label="sioU_PKS_KR.1"
                     /locus_tag="sioU"
                     /protein_end="174"
                     /protein_start="12"
                     /score="45.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="ALITGAGRGLGSILAAGLAEAGMAVGLIGRNRRRLDDTARACARH
                     GAATAVCVADVRSPREIREAARAVHAELGPVDLLVNNAGLVDQGEAPFWEADPEHWWEV
                     FETNVRGTVNACQAVGQEMIRRRSGRIVNVNSIFAVQGDLRYSAYSGSKASLLALAAV"
ORIGIN
        1 ggttcgcctt caccttggcg tcggggatgt ccaggctgac aggtgtggac ttgctcagcg
       61 gcttggcctg ctcccgcgga gcttggccgg tagtggactt cacgctgatg tccggggcgg
      121 ctttggcatc ggctgtgccg cagccggaga ctcccgccag gactccggct gcggcgagcg
      181 caaggaagcc tgtcctgaca gcctgcggga ggttacctag ggtttgcacg gtcggtcagc
      241 tcctcacgct ctggtttcga tgccgcttgg gatcagccgg cctggccggc acccatgcgg
      301 cgcttgagca cgaagcccag accggccgcg gacgcggcgg cggcagcgga gccgacaccg
      361 atcaggccgt tgctcccgtt gccggccggc tgctcgtagc cggcggcgac ggaaccggtc
      421 ggaacctggc tgacctgctt gccggcggag gtgggcacaa ccgccgaacc gcgggccttg
      481 gccttggccg caacctgcgc cttggaggca gcgttcgcct cggaccgggt cagctggtgc
      541 gtgaccgttt tgccaccggc gctggtgctc acgatgctgc cgtcggtgtg gagggtgtac
      601 ttcgcgttct tccacgtaac ggtctggccg gccttgtcga tcgtgccgca cttgaccgtc
      661 tttccggtct tggcgtcctt gctccacagc tcggcggcgt attggccgtg cgcgtcgacg
      721 tagaccttga cggagacgtt ggcgctggcg cttgcactcg cgttggcgct cgcatgggcg
      781 ctcgcgccgg cctccgagac ggtcttggtg gtgaccaaag tcctggcgcc ggcttcggcc
      841 tttgcgttgg ccttggcgtc ggcttcggcc ttggcgctgg cttcggagtt ggtgtgggtg
      901 ttgccgttgg ccttggcctt ggcgtcggct tcggccttgg cgctggcttc ggagttggtg
      961 tgggtgttgc cgttggcctt ggccttggcg tcggcttcgg ccttggcgct ggcttcggag
     1021 ttggtgtggg tgttgccgtt gctcttggcc ttggcgtcgg cttcggcctt ggcgctggct
     1081 tcggagttgg tgtgggtgtt gccgttggcc ttggccttgg cgtcggcttc ggcctttgcc
     1141 tgggcctccg aggagctggc cgaggacgac ggcgccgaac ttgcgtcggc ggccatcgcg
     1201 gaggcagccg gcgcaatgac cgcaccactc gcgacggcag taatagcggc ggtacgtacg
     1261 agactgctgc ggagcctggt gcgcatatag gtgttcctcc tgcgtaaacc taggaattta
     1321 ctagttgtgc cgcatgaacc gttctgtgcc ggtatatgcg gccgccaggc ataagttagg
     1381 aggcgaaccc atcgggcgag ctgccgttgt gtaacagcgg cgtatagggt gtatgaccga
     1441 tatgtcattg ctttaagggt aatgggcggg cggtgagttc tcgccggcgt gaattcccgg
     1501 tgttatgcgg cctgttgagc gtcaaatgac ctgtacatgc actgagctat ggctctgtca
     1561 gctatcgcgc tctttcgtca ggtggtgccg cggtactggg gaattccctc gctgcggagt
     1621 tatttctgcg cctcgcacgg tgaactcgcc cccgattcgt ggatatgcgc tggtgggcgc
     1681 gcccggtgtc gggattcggc tgccggccga acggatgtcg gcgccactgc cccgttcgaa
     1741 cgccaattcc cttggcgtaa gggctggttg acaccaccac cgaaccgctt caccatctga
     1801 gaccagatct gtccagtcac cccaggtact gcgcaacacg gcagcacgct ttgcacagac
     1861 tccaccgcac tgacagcact ccacagcact ccactgcact tcccggcacc gcactgcatt
     1921 ccggtgtctc cgggcgtacc acgcgggtgg gcgccctcat ccgtactcgc tcgcgcagct
     1981 cgcggcgggt ccgaagtcga aaacgggggt aagcacatga agatcctgtc cagggccggg
     2041 ttacgtggct ggggcgccgc gttcgtcggc ctcgtcgccc tgctcggcat ggtcgggccg
     2101 gccgcgcccg ccgcgcaggc cgcgaccgca ccaccgcact tcgcagacgg tttcggcctc
     2161 accgtggtca gccagccgaa atgggcgggc cccgagaagc gcacgttcgt cgtcacggtg
     2221 aagtcccggc aggtcccgac ctacgatgcg atgaagggcc aggtcccggg cgagcacgtc
     2281 ctcatggtca cgctgccgac cgggtacaac ggcgccgccg ccacccgcta tcccgtgctc
     2341 tatcacctgc acggcgccgg tgacctcccg aactccctgt ggaccaagac catcgcggag
     2401 catgcgacca agggcgttcc gctgatcacc gtgtcgccga acggcggcgg ccacggctgg
     2461 tacgcgaact ggcggaaccc cggcccgcgc ggccgccaga actgggagac cttccacctc
     2521 aagcaggtga tcccgttcat cgacgccaac ctgaagacca tcgccgccag ggcgggccgg
     2581 gcgatcgtcg gccactcgat gggcggcttc ggcgcgatcc actacgcaga ggaccggccg
     2641 gacctgttcc gctacgcggg cagcttctcc gcggacctcg acctccggtc tccctggggg
     2701 cgcggcgccg tggtcggcag cggagtggtt ccggcgtacg gcaagccgta cgccgcgccc
     2761 gacgcgatct tcgggtcgcc gttgtggccc ctggacggcg cctggaacgc ggcgagcccc
     2821 gcccaccacg tcacggcgct gcgcgggatg ggcgtcgcga tgtactccgg cgacggtggc
     2881 aacctgctgg acaacccggt ccaggccgcg gtcgagaagg gggcgcaggt gacgaccgcg
     2941 acgatggcgg cgcatctgaa gtcgtccggc attccgtacc gtttcgtgga ttacggcgac
     3001 ggcagcaggt gggccaaggg gtgcaccggc aagcacgccc agttcccgtg tctgcaggcc
     3061 gacatgaacg actacgtgaa gctgatcatg aagcgtctgc ggcacccgtg agccgtgcgc
     3121 agggccggcc ggcggcgctc cgtggcggag gggcagcggc gtgaaacggc cgtcgccggc
     3181 caccgtggcg ctcggcgcga tggtgcctgt cgtgcgggtg ctgatgccgg ccggtgccgt
     3241 gatggtggcg gggaacggtc tggtcccggc ccggtacgtg ccgtggggcc gggccgcggt
     3301 catcgcactg gccgtggtgc tcgtcgtccg tgaggtgcgt cgccggcgaa ccggcggcgc
     3361 accggcgggc cgaccggcac cgcgcaccgg cgggacccgc aacgagctga acgggatcac
     3421 gtacggtcac gcgctcatgg ccgacgtgat cagccaggtg acgttcaacg acgtccgcat
     3481 gcccccgacc ttcaagggca ccctggacga tgccgcggac cggctcgcgg agtcggtccg
     3541 caagcagtgg cgggacgagg aggaacagcg caaggtccag gatccgatcc cgctgccggt
     3601 gcgctggcag cgggcgtccg acgagctgac ggaccactgg tccaacatct gcctcgcgcg
     3661 gcccgggacg ctccccgtcc ccggccccct gcccctggcc ggtcaactgc acgagatcgt
     3721 ggacgtgtac cggcggatcc cgtccgcgcg gctggtggtg ctcggccggg cgggagcggg
     3781 gaagtccatt ctgaccatac ggttcgtcct ggatctgctg aaggcccgga ccgcctcgac
     3841 cgaacccgtg ccggtgatct tcagcctcgc gtcatgggac ccggccatgc ccctgcgtcg
     3901 ctggctgacc ggccaactgg agcgtgacta ccccgggttg gcggtcaccg gacccggccc
     3961 cggcgcctcg acactcgctg ccgagctggt cgagagggac cgtatcctgc ccgtcctgga
     4021 cgggttcgac gagatcgccg acggactcca ccgccgcgcg ctggagagac tcaacggtca
     4081 cgcggccatg cacctgctgc tgaccagccg ccgcgacgag tacgccgccg ccgtgcggaa
     4141 caccaaggca ctcaccgcgg ccgcggtcgt cgaactgacc gacctctccc cggccgacct
     4201 ggagcactac ctgccgcgca cggcgcgcaa gacgaccgcc acctcgaccg ggtgggagcc
     4261 cgtcctcagg tccctgcgcg cgcatccgca ggacccggcc ggcgccccgc tcgccgcggt
     4321 gctgacgact cccttgatgg tcgcgctcgc ccgcaccctc tacagcgaca ccccggaccg
     4381 caccccgtcc gagctgctgg agacccggtt cgccgcgccc gaggcgctgg aggaccacct
     4441 cttggacaac ttcatcccca ccctctacca ggaccagccc cccgctcgcc gcgcccgcgt
     4501 cctgcactgg ctcggctacc tcgcccagca cctggaccgg ctcggcaccc gtgatctcgc
     4561 ccggcacccg gaccgtccgg gcacccgtga tctcgcccgg cactcggacc gtcccggcac
     4621 ccgtgacctc gcctggtggc agctgggcca cagcctccgc cgttcctcgc gcaggtgcgt
     4681 gatcgggctc gtggccggtc tggccctggg gctcgtggac gggctggtga tgtgggtcct
     4741 gacctggtac gcgttcgggt tcggacccgt gctgggactc atgaacgggc tcgtgaacgg
     4801 gttctcgttc gcctccatgt ccgctctggc cttcgggatc gtgtacgggc acaggtacgg
     4861 ggagacggca tgtgagccct cgcgcgtccg cgtacggctg ctcggcggtg cgaaggagat
     4921 gcgcacggag atgcgcaagg agttcgtccc gcggctggcg atcgggctcg tgggcggatt
     4981 cgggttgggg gtcctggtct ggctcatggc cgcgctcggg ttcgcgctcg tggtcgcggt
     5041 gcgggactcg cccgggagcg cgctcgcggc cttcctcgcc accaggtacg accagggctt
     5101 caacgccgcg ctcctgtacg gcctgtcggc cggcctcgcg tacgcgctca tggccgggct
     5161 ggaagccccg atcgacatcg aaaccgccgc cagcccccct gacctgctgc acaccaaccg
     5221 cacgaccgcg ctcttccacc tgctcgtgct cgcgctcgtc ttggggacca tgggcggggt
     5281 gctgtactgg accgggtggt tcagcatcgc cagctgggtc gccttcgggc tcgtgggcgg
     5341 tctggggggc gggctggcgt acgcgctcag catgaccgcc tgggggcagt gggtggccct
     5401 ctcccgtatc tggctgccgc tgaccgggag gctgccctgg aacgtgaccg ccttcctggc
     5461 ggacgcccac cggcgagggg tgctgcggca ggccggcgcg gtctaccagt tccgccacgt
     5521 ccggctccag caccacctga cccgcgcctc ccggacgacc tcacacggcg gtgcggaccg
     5581 tgtccgggcc gagcgggccg gctgacgaag cgggccggcc gacgaacgaa ccgtgccggc
     5641 tgccgtacgc ccacggaccg cagaggtcgt ccttcaggca acggcgacgt cttcctttgg
     5701 gcagaggtgg ggtcttcctc ggggcttacg cccgcccgcc gggtccaccc ttcgatgggc
     5761 tgctgatccc gcacctgaga gcgatggatc cggccacccg cgcgaccacg atggaagcga
     5821 gtcgagcacc cttccaggag tagacatgtc gcaggcagcc accaccccca cagctcccca
     5881 ggccccggcc cccgccgggg ccgccgcgtg cgccgtcggc ctgagcaagg tctacgggga
     5941 gggggagacc cgcgtcgtgg cgctggattc ggtgtcagtg gagttcggac gcggccggtt
     6001 caccgcgatc atgggtccgt ccggctccgg caagtcgacc ctgatgcact gcatggcggg
     6061 cctcgacacc atctcggcgg gctcggcccg gatcggcgac accgagctct cccgcctcca
     6121 tgaccggcag ctcacccggc tccgccggga caagatcggc ttcatcttcc aggcgttcaa
     6181 cctgctgccc acgctgaacg ccctggaaaa catcacgctg ccgatggaca tcgccggccg
     6241 caggcccgac caggagtggc tggatctggt cgtagcgacc gtcgggctgt cgggacggct
     6301 ccggcaccgt ccctcgcagc tctccggcgg ccagcaacaa cgggtcgccg tggcccgcgc
     6361 gctggcgagc cgaccggaga tcatcttcgc ggacgagccg accggcaacc tcgactcccg
     6421 ctccggcgcc gaactcctgg gcttcctcag ggaatccgta cgcgagctcg ggcagaccgt
     6481 cgtcatggtc acccatgacc cggtggccgc ctcctacgcc gaccgtgtcg tcttcctcgc
     6541 cgacggacgc ctcatcgacg agcttgccgg ccccacgccc gaaggcgtcc tcgaccggat
     6601 gcggcgcttc gacaccaagg accgcacgag ctgacgccgg ctcccacgcc ggcccctgcg
     6661 cccctcatcc gtctcgcgat gtccctgtcg cgtacctcca ggaccaccac atgctgcgta
     6721 ccgccctgcg caacgtcctt gcgcacaaag cccgattgat gatgaccgcg ctcgcggtgc
     6781 tgctcggcgt cgccttcgtc gccggcaccc tcgtcttcgg cgacaccacc gccaacgcct
     6841 tccgcaccgc ctccgccgtc agcctcaagg acgtcgccgt cgccgtgcag gcgcagatgt
     6901 ccgaaccgga gtcggtcccc gctggcggcc cggccaaggg cggggagggc gggtcgacca
     6961 ccgtgctgga cgccgccctt gcgcagaaga tccgcgcgct gcccggcgtc accgccgtac
     7021 gccccaccat caacggggag gccgtcctgg ccgacaagga cggccgtccg gtcaacgccg
     7081 acaaccccga aaagcacctc gccacgaact accagcccgg cacggccggc aaggacagcc
     7141 gcttcccgct gaaggagggc cgggcccccg ccgccgccgg cgagctggcc ctggacgcca
     7201 agaccgccga gaaggccggc tatcggatcg gcgacaccgt ccgcttcgcc accgacgggc
     7261 ccgcgctggc caagaagctg gtcggcatcg tcaccaccga cgacccgcgg gtggcggccg
     7321 gcagcacgct ggcgctgttc gacaccacga ccgcgcagaa gctgttcctc agcccgggcc
     7381 ggttccacga gatcgcggtc gcggcgcggc ccggcaccga cgagcgtgcg ctgaccgccc
     7441 gggtgcaggc cctgctcccc gccgacgggg ccacggccac cagcggcgcc gacctggccg
     7501 cccaacagtc cgcgcagatc accgcggaca cccagttcct gaccaagctg ctgctggcct
     7561 tcgcgggcat cgcgctgttc gtcggcgtgt tcatcatcgc caacaccttc accatgctgg
     7621 tcgcccagcg cagccgtgag atcgcgctga tgcgggcggt gggcgcctcg cgccgccagg
     7681 tcgtacgctc cgtcctcatc gaggccgccc tcgtcgggct cggggcctcc gccgccggat
     7741 tcgcgctcgg cctggggatc gccgccgcgc tgcgcccgct gctcaacgcc gggggcgccg
     7801 ggctgcccga cggcccgctg gtcgtctcgc cccaggccgt gctgtcgtcg ttggcggtcg
     7861 gcgtcgtcgt gaccgtcctg gccgcctggc tgccgtcccg caaggccgcg aaggtcgcac
     7921 cggtcgaggt gctcagcagt gccggcgtgg cgccgcccgc ccgcaccctg cgggtccgca
     7981 acgtgctcgg cgcgctcctg accgggctcg gcatcctggt catgggctac gtctgcacgc
     8041 tcgacaccac cgacaagtcg aacctgctga tcgccatgct cggctccgta ctgaccctga
     8101 acggcgtgat cgtcctcgcc ccgctgctct cccgccccct gatcaccctg gccggcgagg
     8161 tcaccacccg cttcttcggc gtcagcggca agctggccag ggagaacgcg ctgcgcaatc
     8221 cgcgccgtac cgccgccacc gcctcggccc tgatgatcgg gctcaccctg atcaccggtc
     8281 tcaccgtcgg cggatactcc acgcagcagg ccatggatga ggaggcggcc catggcacca
     8341 ccgccgactt ccagatcagc aacagcaacc acaccggctt cgtgcccacc gacgcggcca
     8401 aggtggccaa ggtgccggga gtcgccaccg ccgctcccct caccgtcgga aacttccagg
     8461 cacgcggtca gcacgccggg atcgccggga ccgacccggc agccttcgcc aaggtcacgg
     8521 acctgacgtt ccgcgagggt tcactggcgg gcatccgcgc cggcaccgtc gcggtgtccg
     8581 acgagttcgc ccagaagacc ggtgccggcg tgggcgacac gcttgacgcc gccaccgacc
     8641 ccatggagcc cgggaagcac ccgaccacga agaagctgaa gatcgtcgcc gtgtacgagg
     8701 cgaaccccgc tgtgacccag gcgctgggca ccctgcacga cgtcctgccg tacagcgcca
     8761 cccacacgct cgacggcatc atggtcaagg ccgagcccgg caaggccggt tcactggagc
     8821 acgacatccg cgcggcgctc ggcaacagcc cgctgctcaa ggtccagaac acggaacaga
     8881 tcaccaagga agcacgcaag aacctcacca ccgccctcaa catgatctac gggctgctcg
     8941 gcatggccgt cgtcatcgcg gtcctcggcg tcatcaacac cctggccctg tcggtcatcg
     9001 aacgcacccg ggagatcggg atgctgcgtg ccatcggact cgaccgcgcc ggcatcaagc
     9061 agatggtccg cctggagtcc gtggtgatct ccctgttcgg cgcgctcctc ggcatcggca
     9121 cgggcacctt cctggcctgg gccggcggcc acctgatgac gtcgtcggtg gcgacgtacg
     9181 agacggtcct gccgtgggcc aagctcggcc tcttcctcgc gctggcactg ctgatcggcg
     9241 tcctcgcggc catctggccg gcccgcacgg ccgcacggct gaacatgctg cagtcgatcc
     9301 aggcgcacta ggggcccgcc cgggcatgat gcggtccgct ccggcccgga tccgggtccc
     9361 ggtcccgatg cgccgttgcc ccgttgctgt ccccgtggag gggcggcaac ggggcagcga
     9421 cggggcagca atgcggcgta ctggatgggc atggtcggat ggacagcgac cggacaagga
     9481 ccatgcgcgg cgctcgccca cgggatcagc cgcaccacag aaggaacgcc ggatgagcat
     9541 gtggaccacc aggctggatg ccgcgggcat tcacgacccg cagctgcgcg aggacttcac
     9601 ccgacagcgt gcgctggtag ccggttacaa acgcgcggcc tatatcgccg tccttctgct
     9661 cctgccgcgt ccgctggccc cccacatgat cgcggccacc gcattcatgc accacaccga
     9721 caaccttctc gaccacggcc cgctgcccca gcgcgccgcc gcctacgcgg cgtgggagga
     9781 ggaggtgaac caggccatcg ccaccggcac cagcgaccac cccgtgatcc gcccgctcct
     9841 gcacaccggc gcccgtcacc cccggctcct cgggcacgtc aaggacttcc tccgcaccgc
     9901 ggccaccgat ctcgaattca ccggcttcgc cacggagtcg gactaccagc gctacctcga
     9961 cgcgtactca ctgccggcct tcatgctggt ggccggcctg ctggtgcccg gtgacgaacc
    10021 cgccggctac cgcgccgcct gccgcaccta catagacggc agtcagcggc tcgacttcgt
    10081 caatgacctc gccgaagatc tggccgagga caggctgacc gttccccagg acaccctggt
    10141 cagccacggc gtgacccgta ccgacctcgt cgacgcccag gacacccccg aagtacgcgc
    10201 tctgctgcgg cacctcctcc accaggcccg cgccgatctg gccgccagtc accgtgtgat
    10261 cgagctcctg cctgccgcca accgtccctt cgcccgggcc ctgatagccc tggaaaaggc
    10321 caccgtcgac gcggccgggg ccaaggggcc gggcctcctg acctccgctg cccgacccgc
    10381 cgttcccgcc ctgttgacga tcctcacgcg cgaataccgc cacgcgcgca ggctgcgccg
    10441 ctcgcgtgcg gagggctccg agtgaatcgg gtcagtgagg gggtccggga tcacgccgac
    10501 gccaacccgg ccgactctgc ggcgaattgg gcggtgaaat gcagcaacgc gtcggttgcc
    10561 tgcggctcgc cgaccgtgat gcgtacgcct tcctcgccga cggcgcgtac gagaatcccc
    10621 tggcgagctg ccgccgcggc aaaggcaggg gatcgtgggc ccagcggcag ccagcagaag
    10681 ttcgccgcgg acggtgtgac gtcccagcct tggtggcgaa gcccttcggt gaggcgacct
    10741 cgttcggcaa tgacgcgatc cacctgccgc aggacctcgg gccgacgcgc gagggcggcg
    10801 cgcgccgcgg cttccgcgat cgtgctcacc gaaaacggca gcagcctgtt gcgcagggtg
    10861 tgtgcgatgt cccgcggggc aagcgcgtaa ccgacgcgca atccggccag tccataggcc
    10921 ttcgagaagg accgcagaac caccatattc gggatgtcgt gatacgcctc cggcccgttg
    10981 agggtgtctt ggccgccggc gaattcgcgg tacgcctcgt ccaggacgat gaccacgtgc
    11041 tccgggacct cgcggaggaa ggcgagcatg ccggcggtgt cgagggcggt gccggtgggg
    11101 ttgtgcggat tgcacagcac cagcgcgcgg gtgtgggggg tgatgccgtc cagcatcctc
    11161 gacaggtcgt gcttgtgctc cttgagcggg acttccacgg gcttggcgcc cgctgcgttc
    11221 acgaccaggc gataggcgtc gaaggacggc cgggcgtaga tcacctcgtc ggtgggttgt
    11281 ggcgccgccc actggatgac gtgctggagg atcgcggcgg agccggggcc gacgaccacc
    11341 tcgtggtccg gtacggagta gaggtccgct atcgcttcgg tcagtcggcg ggagaagggg
    11401 tcggggtagc gattcgcccc gagcagtgac tcccggagca cctcttccag gtgggcgagg
    11461 gggactgccg gcatctcgtt cagggaaagc tgatgccctt ctcccggatg tgtgggagct
    11521 ccgggatgtg ccgggccggc ggctctcgtc atgaaaaacc ttccttggtg accgacccgc
    11581 tgtccggcgg acgtcatcag gggtgcgtag ggaccttgag ggcgtcgtcg aggaacgctg
    11641 tcgtatcggc gagggcgcgg tcctggtccg agtcgtggaa gatgccgtgc agcgctccgt
    11701 cgtagacccg ttccgtgagg tggaaaccgc ggagcctttc gattccgctt ctggtctctt
    11761 cgagctgggc cagtggatcg gcgtcgccgt gcagccagag ggtcggcagg aaggacaggc
    11821 cgcccccgtc gttgatccgg tccaggcacg tgacgaccga ctccagggtc ctgcgcacga
    11881 aggcgccgtg ccagatcagc gggtcctcgt tgtagcgggc ggcctcggcg gggtcccggg
    11941 acatcaccga gccgacgtcc atcggcattt cgggaatctc gtcgaaggcc aggagagagg
    12001 tcgccgtgtg ccaggagccg agcacgggcg cgacgaggac gagtgcggaa aggtcgtcgg
    12061 gacggcgttg cgcgtagcgg gcggccacca tcccgccgat cgagtgcccg atcatgacga
    12121 cgggcaggcc cgggtggtcg ccgcgcgcct gttccaggac cgtgccgacg tccgcgacga
    12181 gttcgtcgta gtccgtgacg agtgcgcgct ggccgtccga ccgcccgctt cccatgtggt
    12241 ccggggcgta gaccgcggcg ccgtgccggt tcagggcgct ggccagatgc ccgtaccggc
    12301 cggcgtggtc ggcgtagccg tgcacgaata tcgcaaggta cctgggcgtc ggatgcggcc
    12361 agatgtgcgt gtggatcggg tgacggacac cggtgaaccg gcgcgctgtg acctcggaca
    12421 tcgctctcac tcccctttcg cgggcgttct ttcgtgcggt gcggttcccg cccggctcac
    12481 gtcggccggg cgtacggcgt cactccgcga gttccacctg gtagtcgcgc atccagtcat
    12541 tgatctttat gagggactcg aacccgaccc gcagaaagcg gagttccccg ggagaggcct
    12601 tccgcacggt gtcgaaggcc ttcgccgcgc tcttctcgtc catcagcgcg cgcaccggtg
    12661 ctccggcatc gtccatgaga tcgccgagcc tgcccttgag cagctggtcg tacgccgggt
    12721 cggcaatcgt cgggtagggc tctttcttcc tggtgagaac ggactcgggg aggtcggggg
    12781 ccatggccgc gcgcagcagg ctcttctcgc gcccgtcgaa ggacttcatc gaccacggca
    12841 cgttgaagac gtactccacc aacgagtggt cgcagaaggg cacccgcact tccaggccca
    12901 cggccatgct catccggtcc ttgcgctcca ggagcatcgg aaggaagcgg gtgaggaaga
    12961 ggtggttgac ggtgcgcatg cgccggtcgg gttccggctc cccgggcagg acggggacgg
    13021 cggcgatcgc gtcggcgtag ctgtcggcgc ggtactcgtc cagggagaga cgttcgggca
    13081 gcgcggggtc gaggaacgcc gggccctggg cggcaccggc gccggccgcg tacatccagg
    13141 ggaacgtccg cgcacgggtc gcctgctcgt cgtggaacca ggggtagcca ccgaagagtt
    13201 catcggcgcc ttcgccggac agcgccaccg tggaacgctg ccgaatcgcc ttgaacagca
    13261 ggtacaagga cgtgtccata tcggcgaggc cctggggcag gtcgcgggca cggagcacgg
    13321 cggcgcgggc cgcgggatcg gacagcagtt tcgcgtcgag cacgatggac tcgtggtgcg
    13381 cgccgatgtg gccggccagt ttcgccgcat agtcggcgtc gtcggtgaga gcggacccat
    13441 cggagaccgg catcgccgcg tggccggacg gggcgaagcc gaccgagaag cactggagag
    13501 ggggctgtcc gctcggccgc agcgcctccg cggcgagcgc cgccacggag ctggagtcca
    13561 ggccgcccga cagcagcgaa cacagcggca cgtccgcgac ggtctggccc gcgacggccg
    13621 cctgcagcaa ggcacgcacc cggccgacgg tggtgtcgaa gtcgtcgtcg tgcgggcgtg
    13681 ccgggagctg ccagtaggcg gtctcggtga ggttcccgcg ggagacccgg acgaggtgtc
    13741 ccgggcggac ctgggacatg ccgtcgaaga tcgcgtgtcc cggtgtgttc acccacgtca
    13801 tgagctcccg caggccggcc gggctcagcc gggcccgtgc ctcgggatgg gccaggatcg
    13861 ccttcggctc cgatccgaag agcacgccgt ccgacgtggg gtagtagtag agcggtttga
    13921 tgcccagccg gtcacggacc agcagcaact cccggctgcg ggtgtcccag agcgcgaagg
    13981 cgaacatccc ggtgaggtgc cgggtgaagt cggtccccca ttccagatag gcacggagca
    14041 cgacctcggt gtcgctgtcg gtccggaacg agtggccggc gccgcgcagt cggttccgca
    14101 gtgcggcgaa gtcgtagacc tctccgctgt aggagatgac ggcggcgacc tcgccgtctt
    14161 cctcagcggt catgggctgc gtgccgcccg cgaggtcgat gacggcgagc cgccggtgcc
    14221 ccagggcgac gtggctgccg taccagacgc cctcggcgtc cgggccgcgg caggccatgg
    14281 tgtccgtcat cgcctgcacg gcggagcgct ccgcgccggg gtcccgctcg aaggccaccc
    14341 agcccgcgat tccacacatc gtctcttcct cccctcgccg gtcaggccgg cagcgcaccg
    14401 agctgtcggt gcagtccgag caggtccatc tcgtcccagt gctgggcgaa caggccgtcc
    14461 tcgacgagga agatgtcgat gagaccgacc gagaagtgct tgccggacgg cgggatgtcc
    14521 aggatcgtgc cgacctgccg gccgctgaag gtcatgcgtg cgacgacctt gtccccctcg
    14581 acgacgaggt cgtccagggt gaggcgcagg tcctccaccg acgccgccca gcgacggacc
    14641 gctccccgca ttccttcgat accgcgctcg accgccgggt tggggtgccg gtagtccgga
    14701 tgcagacagc ggtccaagtg cttcgggttt ccttcgttgt acgccgccag gaaatgttcc
    14761 atgaggtgca gcgcggcttc tcggtccacg ggtggtcgcc ttccgatgta ctgaactcgg
    14821 tccggagtgc tggtcagggg ttgccgtcgg gagccggctc ggcgagccgg tccagccgcg
    14881 gcgggtgcgt cggggccacc tcggcaccga gcgtggtcgc ggcgatcagg tcacaggcgt
    14941 cggcgttgct gtacgggtgc atggtcccgg cccgcacgtc ccggtgggca cgctcgtaca
    15001 ccgagccggg ccgcagcgcc ggcgtgccga tgatcctgat cacgcggtcg acgacctcca
    15061 cggcgtggtt ggtgccgacg gttttggcca acacgacgcg tgcggtgccg tgttggatgc
    15121 tcagctcggt ccacaggcca ttgcccatga cctcacgggt ggtccgttcg atgagggcgc
    15181 gggaggtttc gatcagggcc tcgcactcgc tgatctccgc ccgtatgtag ggccggtcgt
    15241 cccagccgcg gctcaggacg tcccgcacgc actgctcgaa ggccccgacg gccacgccga
    15301 gatagaccgc cgcgaaggtg ggcatggccc agccccacac ggtctggagc agcgaaccgt
    15361 ccagtgtgcc gacggggaag ctcgtcagga cgttctcctc cggcaccatg acgtcgcgga
    15421 gttcgatgtt ctcgctgcgg gtggccctga gggccgaggt gttccaggtg ccgtccagga
    15481 cccggacgcc ggggctgtcg gcgggaatgc ggaacaccag gacctgcgga ccgtccgggt
    15541 gctcgcggta ctccgccatc gacgtcatgt gggtcatgac cgccgagccg gtgccgaagg
    15601 tcttgtcccc ggtgacgagg taaccgccgt ccaccttccg ggccttggcc ccggtgctcc
    15661 ggacgagcgc gtgcccgggc tccgcggtgg cccccatgag gatcacccgt ccgtcgacga
    15721 tgtccctgag cgtccgccgg gcgcgctcgt cccccgtggt ccgccagttc ctggccatct
    15781 ggccggccat cgagagatgc atgttcacgg cgagcgccgt ggaggcgcag ccggcggcca
    15841 ggcgttcctg ggtcagggcc atgtcgccga gggtgccgcc cagtccgccg agttcctgcg
    15901 ggacggtcag cgccaaatag ccggcgtcgc ggagctcgtc gatgttctgg tgcgggaact
    15961 cggccttccg gtcgtattcg gcggcccgct cgcggaaggc cgccgccagt tcctccgcca
    16021 tcgcgacgta ccgttgccgt gtcggctggg tgatcagagg gcgcataaag actccagctg
    16081 taggggtgct cacccggagg gtgccgggtc cgcgaggtcg gccgagatca gccaggtacg
    16141 ggcggctccg ggggtggcgc gcgggggtgt ccggggaacc agccgccctg ccgcctcggc
    16201 cagttcgccg ggttcgcgca cgacggcctg ccagccccgg ccgccgagcc acgtctcggg
    16261 gtcggccaca ccggacagcc agggacgccc ctcgtcacgc atggtccgca gccactcctg
    16321 catccacggt gcgcggtaca ggtcggtgtt gacgtgctcc aggaagcagg cgctgccggc
    16381 ggcggagagc gcggtcaccc ggtcgaccac cgcattcacc tggtgctcgg tcaggtagta
    16441 gagcactccc tcggccagcc acgccgtgcg gaggtcactg cggaaccccg cgtcgaccag
    16501 cgcggacggc cagtcgtcgg tgaggtcggc accgaccgcg atccggtgac accggtcggc
    16561 ggtcagggag gtgcgggaca ggaaggcggc cttctcctcg actgccgcgg gcaggtccac
    16621 ctcatagagg gtgacgcccg gtggccaggg aagtctgaag gcccggccgt ccatgccggc
    16681 ggccagcacg acgacctgcc gggccgggcc ggtggtcacg gcgcgcagca ggcagtcgtc
    16741 gaagaacctg gtgcgtacgg cgaggacgtc gtagcgggag ctcggttcgg accgcagccg
    16801 agcgtagagg tccggttcgg tgcgacggac gaattccacc gcgagcgggt cgtggaacaa
    16861 ccggtcgtca cgcagcgatt cagctgccct ggcgcaggcg atccaatggg cggtctcgat
    16921 caaactcgac atggtgctct tctcgccgga gccgggcggt ggcgcgcccg gcacggggca
    16981 ccaccggtcc gcggccgtct caacgggcct gggccgcgat gtcgtcgtcc ccgagcgctc
    17041 gggacagtcc gcgacggagc gaccagtgca ggatctccgt ctggttgtgg cggaactggt
    17101 tccagtagtc ctcgcccgcc ttgttcctgg tgcgcagcac gacaccgatg tacgccttgc
    17161 cgtcggcgac gatgaaggac atccggtgtt cgagcagctt gtccgtgtcg ccgaggagca
    17221 cttcgcgctc gctggcctcg aacacctcgt aggggccgag gcgttcgccc accgtgggca
    17281 gcggctggtc ccgcgtgctg cgcatggtgt tgggcttgac cccgaacggg cggaggacca
    17341 gggcctggac gcggatccag aggtcgatca accagaacgc ccgctccggt gtcaggctgg
    17401 ggcggtccat ggccagccgg gcgagctctc tcgcatcaac tttttcctgg tccggaatta
    17461 atgattccgc cgcttcggcg tgggtgtatt ccccgctgtc gcggaaacat gcgagagccg
    17521 tgtcgtccgg tattgaacaa ctagctactt ccattgtgga tcccccaagt gtggcgccga
    17581 tgccctccgg gcctcaaggc gccaatgcgt ccgaaatcaa cgacgtgaac taacgcatca
    17641 ccggggcgaa tctaacacct aaaagtgatc ttctaggggg ctagccgcgg attttgccaa
    17701 tgtggcgtgc gtcacatcgt cttgttcggg atagccccct tgtgcggcag aagttcggat
    17761 gcctatggtc ggcctcagcc gggtgacaag agtcccgggg ggccggctac aaattgtgtt
    17821 ttacgtggcc ggccgcatgc ggcgcgatcg acgcgaccgc aaatttgccg aaaggtaagg
    17881 tgaacggcat gagcactgcc gccatcgtcg gccaggagat cggtgtcgac ggcctgacgg
    17941 gcctggatgt cgacgccctg gagatcagcg actacatgga cgagacgctc ctcgacggcg
    18001 aggacctctc cgtgaccatg gtctcctccg cttcgtgcac cacctgcatc tgcacctgca
    18061 gctgcagctc ctgaatcacg ctgctgtgcg gggtctgacc ccgcagcctt cggtcctgcc
    18121 tgctccaatc tggcaggccc gagggcccag cagcggagga cgaggagggg ggacggcatg
    18181 agcgctgttg ccgccgtcgg ccaggacgtc ggcgtggcag gcctgacggc ctggatgtcg
    18241 acgctctgga gaccagcgag tacctggaac gaggcgctgc tcgactgcga gggcctgccc
    18301 ggtgacgtcg atcggctccg tctcgtccac cacccgtatc cgctccggta ggtgcagctc
    18361 ctgagctgat caccggcgcg gggtccgccc cccgccgccc tcggacctgc ccgctccaat
    18421 cgggcaggtc cggggctccg gctcggacga tattcccgtg ccagggcgat acgggagccg
    18481 aacggcggcc aggccgtcgg ctcctgtcac cacctttact atgcctgatc acgatggccg
    18541 gggaccaccg cggtccagcc tgtgttcagc attccctttt acgccctgcg gcggctgttt
    18601 atccggccat tcatgtggtc gagatcaggt tcattaattc ggtcgaggcg aggccgggca
    18661 tggagcgtga tttcggcgtg cgcggacggg ggtaccgccg tgccgccggg atattaattc
    18721 tgctttgacc ggccatgctc tgcttccggt aacagaaagc tggtatcacg tgcgacccgt
    18781 aatcctggtg cacggtctat tgggcacgga ggatgctcat tatgctgggt gccggcgttg
    18841 gtggagacac tccgttaccg aaatacgtct tccgggccac ggagccggcg gcgaggtccc
    18901 gtcacatccc gccgcggcgg cgatagaccg cctccgagag gcgatcggag aacagccgca
    18961 gccgcccgtc gtcgtggggc tttcctacct gggtgccgcc gtggcattcc gggccgcgga
    19021 gagcgctccg gacagggtgg ccggggtcgt catgtcgggg tattcgttcc tggtgtcgcc
    19081 ggacaccctg aatcgctggc tggcgggctt caccagaatg gcgacgcacc agcagggctc
    19141 tcgcaaccac tttgccgaac tgcacggcga gaagtgggag aagctgctca ccgcgacctt
    19201 cgacgagctg tccgacgggt gcctgcggct gcccgacgtg gaggacctca cccgcgtcgg
    19261 gaccccggtc caactcgtca acggggcgct gttgcagaac gagcggaacg cgatcgggcc
    19321 ggcggccgcc gcgggcgccg atgtcgcggt cgttgccggc gccggacacg tcgtgccggt
    19381 ggacgcgccg cgcgtcttcg ccgccaccgt cgaggagttc gccgcgcgcg tcgacgccgg
    19441 gcgcaccgcc ttccacgagc ggcggcgtgc cgccgagcgg gccgctgacg tcgccgccgg
    19501 ggaagccggg aaagccgggg aagccgcgga agccggggaa gcagcccatg tctaggccgg
    19561 ggatcaggta cgccggatac ggcgtggtgc gcgtctgctc gcagccggtc gatgtcgtgg
    19621 cgcagctctc ctcgcgcgag gtcgcccgcc tctgcgacga gctcagggag ctgcggcgcg
    19681 actggcagga ccgggcgccg cgggtggcgg aggaactcac ctcgctggta ccggacctga
    19741 ccgatcgcga gcagcgccgc gccgtgctcg cgctgcgccg gcgcctgcac cgcgcggcgg
    19801 acgtgccggc ggccgcgctc gacgtcctcc acctgcccgg tggggccgac gtggccggtg
    19861 ccgcggagct gcgtgccctg gccgctgcgc gcgacgacct caccgcccgg tgggaggacg
    19921 cgtacgaggc ggcgctccgc gcggagcaga aggtgctggc ctccgcggcc ctggaccgct
    19981 ccctgcgcgc gggtgcccag ctgagcgcgg acggcctgct gcacaacatg gaccgttacg
    20041 ccgccgcggt cgccgacggc accgcgcacg gcaagcggga ccggatgacc gagtccaccg
    20101 tgctcaatct gctgacgcgg agcgccctca agccgtcccc cttcggccag ttggtccgca
    20161 cccagccggt gctcctccag gagcgcgcgg cggccgaggc gccctccgcc gagctcgacg
    20221 cggacgcgca ggtgtccgtc tgccggctgc cccgccagct cgtgagctgg gtggaacgct
    20281 cgctcgccga ccaccccgcg ttccggtccg cggcggttct ccgccgggca ccggtggtgg
    20341 gatcgtcgag cgagggagtc gtcttcctcc tccggggccg ggacggcacc cacgagccgg
    20401 ccgccaagga gcggctcgtg cgggtcccgt ccagcacggt ggtcacggaa ctcctcgcgc
    20461 tgtcggcgga cttggcggta cccgagcggg acgtgcgggc acggtgcgcc gcgcttcccg
    20521 acacggatcc ggccgccgcg cacaccgcgc tcgacacgct gatcgagcag ggcgtgctcg
    20581 cccgcgacct gggggtgggg gaccagcacc cgcaccccat cgcgcggctg gtcgccttac
    20641 ttccccagga ctgcgacgcc ggcctccggg agtgcgtgga ccggatggcc gccgccgagt
    20701 ccgcgttcga gaccgccggg ctcgaccggc gggaggagct catcgcccag atcaagcggc
    20761 aggtcgccga ggtcgccgac cggtgcgggg tcgccacccc accgatcgag gcggcacgca
    20821 cgctcctgta cgaggacacg gtggtggcca cgccacgcac cgagcccgcc gaccgctggc
    20881 agcggcacct gcccgccctg tcccactggc accggctgct tccgctcttc gacgacgccg
    20941 cccacgtccg ggcgatcgtc gccgacgtgg tcaggacgcg gttcggcccc ggcccgcacc
    21001 ggctcctcac cctgttcgcg gcgctgtcct cggccaaggt gcagctgctg ctcacccagc
    21061 ggctgaccga tgtctccgcc ccgatgccga cgcagctgcg caccctccag gacgcggtgt
    21121 acgagctggc ccgcccggag gacggcgccg agacggtgat cgatccgcag cgggccgcgg
    21181 agctcgccga gaaccttccg ccgtggatac cccggtggtc ccgggcgagc tggagcgtgc
    21241 agcacgatgc gtcccccgac ggcgggctgc tcgtcgtcaa cggcggttcg atcggcttcg
    21301 gacgtgccat ctcacggttc ctgccctcct acgccgcggt cggtgacggc ggattcggcg
    21361 agctggtccg ggcggagatc gcccaggacg accgcacctc cgcgccgctc accgatctct
    21421 cggccgtgct cggcatcaat gccaatgtgc actccccgct cctgggcagc tacctccgct
    21481 acccctgcgc gaccccggag gagtggggcc aggaccccgg cgtctccctg gaagagtgct
    21541 gggtcgagtg cgacgagggc acgggccggc tgctgctccg ccggggcaag gacggcccgc
    21601 ccctgcggct ggtgatgctg aacttcctgc tcaacgaact cgcgccgcgc ttctaccagt
    21661 tcctcaactt cttcggcgcg ggcagcctgg ccaacctcgc ctggtgggac cgggtcgatc
    21721 agcgccgggg cgacccgcac accgtccgcc ggtacccgcg ggtccgctcc gggagcctgg
    21781 tcctggcgcg ccggacctgg aaggttcccg ccgaccggct cccggacgtc gccaccggga
    21841 acggcgccga cgcattcgcg gaggtgcggc gctggcagga gtcgctgggg ctcccggacc
    21901 gcgtcttcta ccgcggcttc accctccccg atccgctcgt cccgacgtcg gaagaggagc
    21961 agcacacctg ggcgaggacg ctcgcacgtt tcccgacctc ggccgaacgc aagcccacct
    22021 tcctggactt caccagtgtc accagcgtgc gcgcctggca gcgggcactg cgccggtgcc
    22081 agggcgacct gacgttccag gagtgcctgc cgacggtggg cgacgacggt gcacagggcc
    22141 accgcgagcg gctcaccgag gagttcatca tcgagaccac tgagggggca cggtgagtac
    22201 cgacacggcg cactcctggc tgtcctgcca cgtcttccac cacggcgaca ccgatccgtt
    22261 gctcacggat ctcctcctgc ccatggtcga cgagctgcgc ggcgcgggac gcctggagcg
    22321 ccacttctac ctgcgccact gggagcgcgg tccgcacgtc cggctccgga tgcaggtgcc
    22381 ggccgagcag cacgacgacg tccgggccca ggtcgagcgc cggatcgtcg accacctgga
    22441 gcggcatccc ggccccgccg atacggatcc ggtgcggctg cgggatgcgc tccgccacct
    22501 cagcgagctg gagcacggtg acgcctccga cgccctcatg cagaccccgg aaccgccgaa
    22561 cacggtccgc tggatcgact accggcccga gacggccaag tacggcgggc cggaaggcgt
    22621 cgagatcgcg gaggacgtct tccacgcgag ctcgctgctg accggacagg tgctccggct
    22681 ggtccgcaac gaccgggcgc gcctggggat ctccctccaa ctgctgctcc tggcctcgcg
    22741 ggcgctgggt ttcgggccgg acgaccgcgc cctcttcctc cgcacctacc acgagcgctg
    22801 ggccgcgtac gtctcggacg accgcctgct ggccgcctgg aacgagcagt accggctgca
    22861 gcgcgcggac tacgcgaagc tgatcgccgg cctggacacc ggcgaaccca tcggcaaggg
    22921 actgggcgag cggtgggagc gcacgctcgt ccagtccctg gagcggctgc gcccgctcgt
    22981 ggcggcaggg cgggtgtggc cggcggagac cgaccgctcg gcaccccccg tggtcgcgct
    23041 cgcgaccctc gtcagccagt acctccacac caccaacaac cggatgaacg tccgcccgca
    23101 gggcgaatgc ttcgtcgcct acctggcctg ccgggcggcg gaggagcagg gcgcgagcca
    23161 gtctcgcccg gtgccggccg cacaacgaca gggatgagtg ccatgtccag cagtgaacaa
    23221 aaggatctca ccgtcagcgt cccgtggtcg gtgcaggaag acctccttct cgacgtggcc
    23281 gcgcccacgc tggaggagtc ggtggcactc ggcgagacgg agtcgtggtt ctacctgcgg
    23341 gagaactacg gcggccggcc gttcctgcgg ctgcgtttcg cgacccggag cccgtcggtc
    23401 gaacgccgcc tgaagtcccg gatcatggag cacatcgggt ccgcggcgtc cgacgacccc
    23461 ttcgagcacc agccgtacaa ccacgagcac gactggctgg gcggcgaagc cggactgggg
    23521 ctggcggagg cgttctggac cgagaccacg ccgctggcgc tgcggaccct ccgtgccacg
    23581 cgcggcgatc gagcgctccg cctcgccgcg gccttcgact tcctcgtgtg cagcggcgtg
    23641 ctgctcgccc cccatctgcc gccgcccgtc gccaagttcg gcttcaaggc cggctacctc
    23701 tcctacctgg cgacgttcga gggctacatg ctgctgatcc gggacccgga gggcacccgg
    23761 gccaagcacg cccagcggta cgagcagaac cgcaacctgt tgcggccgcg cctgcgcgca
    23821 ctggtcgagc agatgcagga cccggagggt gacctggccg acgtccccga actggcccgt
    23881 gagtgggcgg tgcggctgcg cggctatctc ccggccatcc ggaagggctt cgacgaaggc
    23941 cgcttctacc tctacgccac cccgcggaag gccgaaacgg ccaagctcac cccgtcgccc
    24001 gacggcctct accgcaggcc gaaggtggag tggctcgccg acctgccgga ggccccggtg
    24061 gccggcatcc accgggccat cgccgacaac acgtactacc agggcatgat ccgcgaggac
    24121 cgccggttcc tggcctcccg gctggcccag gcgtacacca actggcacct ctaccggctg
    24181 ggcttcctgc tggccgaccg gtacacgctc ttctacctga tcgcccgcgc cttcgaggag
    24241 gagtacgacc tcgacgcggc ggagctcatc cggtccgtgc agccggaagc cgaggtctcc
    24301 ggatgaccgc ggccgatacc ggcgcaccgc cgctctccgg tgacccgtcg gagcgcggac
    24361 cgttcgacga cgcgggcgtg gacgccttcg tccgcaggct ccgcggcagt tacgaggagg
    24421 tccacccgca gcactggcag atcgactggc ggaacatccc cagccccttc cgctggtacg
    24481 ccgacctgcc ccgcagggac ctgccgacga tgtcgcggac ggtcgcggcc ggtggccccg
    24541 ccgcggcggc cgcgttcgcc gcgtccgacc cggccacccg gctcggcgcg ctgctccagg
    24601 ccggctacgg cctgaccggt gtgcggtggt accccgccgg catcgccaag agcagccccg
    24661 aggagcccac gccggtccac cgcaacccgc actaccagct ccgccgcgcc atgccctcgg
    24721 gcggcgtgac gtaccccgcc gagtgctacg tggtcaccgc gggcacggcg ggcctggacg
    24781 cggggatcca ccactacgac gcggtgcgcc acgccctggc ggtgctgtcc cgcggccggc
    24841 cgccggcgga gctgacgccc ccggcgggcg gtgtgcggat cgtcctcacc cagccgctgt
    24901 ggaagaacta cttcaagtac ggcgacttct cctaccggct cggcgcgatg gacaccgggg
    24961 cggtggtcgg ccagttcgcg ctcgccgccc gctcgtggaa cctgcccgct cgcgtggcgt
    25021 tcggcgtgga cgagcggcgg atcgccgacc tcctcgggct cgaccccgag gaagaggcca
    25081 ccccggccgt ggtggacatc gcactggggg acccggccga ggcggagcgg gggccggccg
    25141 ccggccgcgc ggctccggtc ggacggcccc gctggctggg ggcgtccgcg ccgcccggcc
    25201 ccaccaccgg tacccgccgc atgcacgccg cctgcctggc ggccggacgc cccggccgga
    25261 cggtcgacct cccgcccgtc gtgctggagg acctggccga ccgggcggac gcggagctgc
    25321 ccgcggtgtc cggacggccg gtgtcggtcg ccgactcctg ggcccggtcg gccctcggtg
    25381 agcagctccg gggcgcaccg ctccccgcgg acgtcctggc ggactggctg ccccaggtgc
    25441 tcgccccgct ggactgcgac gtgaccggga gcggggacgt ccccgccctg acgcacccgc
    25501 ggtgcgtgct ggtcgtccgc tccgtgccgg gggtgccccc gggggcctac ctgccgcagc
    25561 aggacgggcg ccggctcgcc cggcttgccg acggggactt cgggccggtg gtccagcgga
    25621 gcatgttcgc gcactacatg aacgtcggac aggcaccgct gatcgccgtc atggtcggtg
    25681 ccaccgagcc gcaccgcggt gccagcggtc cggtcggcta tcgcacccag catctgctgg
    25741 ccggcgtcct cgcccagcgc ctggccgtgt gcgcggcgcg ggacggcagg tccgcacacc
    25801 cggtgctggg cttcgtcagc ggcgtgctcg acgaggccct cggactgggg gcccgacgcc
    25861 tgacgtcctt gctgatggtc cccgtgggcg gctaccgccg gggcctgtat ctggagaaca
    25921 gtctgagtcc gctcgccgcg gcggcgggcg acgggggtgg gatatgaccg gcactgtgct
    25981 gcgcctgcgc gccgatgcct actacgtacc ggtgcccaac ggggtgtgga tccgtacgac
    26041 ggacggctcg ttcaccctga acggcaagac ggtcgcgacc tgggtggaga aactcgcccc
    26101 cctcctggac cgcggcgtgg tgcccgacga gctcctcggc gcgctcaagc cagagcaggc
    26161 cgccttcgtg gacaagctgc tgaaggcgtt ggagcagcgg aaggtgctgc ggcccgaacc
    26221 cgccgacgag ggggccgacg acccggagtc ggcccgtctc ttcccccaac aggccgagta
    26281 cctgcgccac ttcaccgccc gtcccgcgga gggcttcgcc cgtgtccggc ggcacccgct
    26341 ggccgtggcg ggccccgccg agcgggtggg gccgttggcg acgacgctga tggagaccgg
    26401 cttcggcgac ctcgtgctgc tggacacggc acccgggaag gaactccagg aactcgcgga
    26461 ggacttcggc cggcaggggg cgccggtacg cctgtccggc ccggacgggg acctcgaagg
    26521 acggaccgtg atcggggtct tcgccccggg agaagaagag gacgcctggc ggctgctgga
    26581 ccgggccgaa gcgctcggca gcggcgcctg ggcggcgctg gtccgcggtc aggcgatgct
    26641 cctgaagggg caggtgcccc ggtcgggccg ggcctgcgtc cgctgcgcct ggcggcgcct
    26701 ggcccaccag gccgtcgaac tgccgccgtc cgacgggctc gggtacgtac cggtgtcggt
    26761 ggcggcgacc gtgctggcac aggaggtgtt ccagtacgtc gccggcggcg acgacgccgt
    26821 gctgggcgag ggcgtggtgg tggacctgac ccggctcagc atctggcgca cggacgtcga
    26881 tccggacccc gactgccccg ggcatgcgct gcccgccggc ccggcggacc cgtcgctcgc
    26941 tccggcggcc ggtcggcgga cccggttccc cgactcggtc ttcggcgcgc ggtgcttcgg
    27001 cccgctgttc tcctgcaccc ccgaacagct cccgcagttc cccctcacgg cgctgcgcct
    27061 gcggatcaac ccgccggggc gcggcgagcc gacgggctcg gccgacggcc cggtcatcgt
    27121 ggcggaatcc gtggccgacg cccgcgccga ggccgccgtg accgcggtcg aggcgacgct
    27181 tcccaccagc ggcgacaccg tcgtgggcgt gggcaaggac cgcgccgagg caggtgcccg
    27241 cgccctgctc cgctgggccg acgcggcact ggacgacgcg gcaccggacg acgcgggtgc
    27301 ggaacgccgg gaggggacgg cccgctccga gcgggcccgc gcgctcgccg aactggccgg
    27361 cagggacgtc gagctcagca cggcgcgcca tccgagcgga ctgtggcggg cccgggtgga
    27421 cggcaccgtc acccggaccg gcttcgaccc cgaccaggcg gtggagcgcg cactgctggc
    27481 cgccctggca cggggccaac tcgggcacgg ggacgacgcg acggccgtga cggcgtggac
    27541 gggcacggtc ccggaggagc gccgggtcga cgaggtcgcg tccgcactcg gcctggcctg
    27601 gcgcgaggcc gccctcccgc cgctggtcgc cgccgacctg accggcatcg tcctggctcc
    27661 gggacacgcg ggatgagcga aacgctgacg tcgcgccgcc gggcgccccg gctccccgac
    27721 gaccccgcgg cggagttgcg ccgatgggtc ggcgacgcgg tcgatgtccg caccgcggac
    27781 ggcatgcccg cggccgggga cggccgcccc gtcgtcgtgg tgcacctgga ctgggatgcc
    27841 gacctctcgg acctcccggc ggcggacacg gtcgtcgtgc ccgtgtacgg gctccgcggc
    27901 cgggtcgtcg tcggcccggt gatgcggccc ggtcaacccg gctgcccgca ctgcctggcg
    27961 ctgcgcgtac gggcggcgga tggtccggag ggcgttcccg cgggggcgga ggcggccccg
    28021 cgccggctgt ccgcacggcg cgccggctgg ctgccgcccg gagccctgcg cctggtggca
    28081 gccgtggtgc gcgacgaggc ggagcggctg gccgccggcg tgcccccgcg cggcgtcgac
    28141 gccgccttcg cggtcgggcc cgcgcggttg accggcgact ggcacccggc gctcccgcac
    28201 accttgtgca ccgcaccgca ctgcctcggc agccgccgcc cgctgccgcc accggttccc
    28261 gacctgtcca ggcccctgcc cacgaccggc gtgggctcgg cacgacgcgt cccggctgcc
    28321 cggtacgccg accggctgga gcaggagtac ctcgacgcgt ggtcgggcct cacccggtcc
    28381 gccgcggtcg gcgaccgggc cgccctgccc tcgacgcagg tgcgggtgcc caccgtctgg
    28441 ggattcgacg agatcgcgat cgggcgggcc gaggactacg cgggggcccg gcccgccgcg
    28501 atcctggaag gcctggagcg gtacgccggg tggcactgcg gcggccgcga ccccgtccgc
    28561 ttcgccgcgt tcgccgaact cgacgacgcg gtcgaccccc gctccctgct cctgcacccc
    28621 gacgaggcgt accggcagcc cggattcgag tacacgccgt tcacgccgga cacccggacg
    28681 gggtgggccc aggcgtactc ggcgcacacc gggcggccgg cgctggtgcc gttccacgtc
    28741 gcgtactacg gcgcgaccag gcgcccggac accggcccgc ggttcgtcta cgagaactcc
    28801 aacgggtgcg cactgggatc cggcgtcgaa gaggccctgc tggccgcctt gttggaggtg
    28861 gccgagcgcg acgcctttct gtgcgcgtgg tactccggga cgccgttgcc ggagatcgac
    28921 ctcggcgggc tgacgggcga agccgcccgc gccgtgcgga cggtgcggca ccggaccgga
    28981 cgcgacctgc gggccttccg ggccctcggc gcgttcgacg ttcccgtggc cctgctcgtg
    29041 acgacctcac ccgatccgga gcggccggcg accctggtca ccgcgggctc ggggctcacg
    29101 gtggagcggg cgctgctcgg ggcggtccac gagatggccg ccgccgcgcc cgtgatcacg
    29161 gtggagtacc agcgccgccg ccccgagttg gagcgcgctc tggacgcccc cgacctcgtg
    29221 cgccgcatgg aggaccacgc cctggtcgga gccctgcccg gggcccggcc gcggttctcc
    29281 ttcctcctcg acgggacgcc gccggacccg tcgcccgccg tgacccccgc gccaccggcc
    29341 ggcgacgtcg cggcggatct cgccgcgatg ctcgcggcgg cgcggcgcga cggacaggag
    29401 gtcttcgtcg tggaccacac caccggcgaa ctggatcgcc tgggcctgag ctgcgtgaag
    29461 gcgatcgtgc cgggcaccgt gccgatgacc ttcggccacc ggcaccgacg gctgccgccg
    29521 cccgagaccc tccaggcgtt ccgggccagg aacggcatcg gccccgttga gttccccatc
    29581 gaggaggtac ggcatgagcc gcacccattc ccctgagacc gcggccccgg ccgcccccgc
    29641 ggcgacgccc gaggggctga gtcccctgcc caacggcctg ggatgggtgg tcagcagtcg
    29701 gtccctgacg gttcggctgc tcggcgacca ccggctgggc gtcctggaac cgcagccggt
    29761 catggcccac ctcgtcacga agctgcccga cgaactgcac ccccaggtcg acgagatcgc
    29821 cgcgttcgcc gaacgcgtca tgctgcagac cggccccgca cgccatcagg tgctccgcag
    29881 ggcgttcggc ggattcttcg acgccgacgc gatcgaggcc ctcacgccgg agttgcggag
    29941 aggcgccgag gacaccgtgc gccggttcgc ggcgtccggg ggcggcgagt tcatgaccgc
    30001 cgtggcgttt ccgtacgcgg tgcgcgtcgg ggcgcggctc atcggcttca cggacgacga
    30061 ctaccggcgg ctgcacaagc tgagccagca ggtcgcgctg gtcgcctacg ccgcccggct
    30121 cgacgacccc gcggaggcgg tccgtgcggg ccatgccgcg ctggtccggg tccgggagat
    30181 cgtcgcggcc gcccgggcgg ccgcgccccc ggcgtcggtg ctcggcgcct ggcacgccgg
    30241 gacgttggac ctgtcggacg aggacatcga ggccaacgcc gtgatgctgg tgcaggcctc
    30301 cctggaaacg gtgtccggca tgctcggcaa cgccgccgtg cggatcctcg gcacgccggg
    30361 ggcgctcgcc gacgccgcat cccgggagag tctgctcgac gaggcccttc gtgcggagcc
    30421 cccgctcaag acgctggagc gcgtggtccg ggagccgttc cagctggacg gtcacgagtt
    30481 ccggtccggg caggtcatct cggtccgggt cgcggacgcc aaccggctgg acgacgaccc
    30541 ggtggccggc cgggcgctgt tctccttcgg gtggggtgcc taccgctgcc tcggcgcgcg
    30601 actcgcccgg caccaggcgc gggagctctt ccaggcgctg caccacctcg cgccggacgc
    30661 cgcgccggcc gacgcggaga tcgagcgggt ccggcacatc cgcttcgaca tgccgcggcg
    30721 gctgcgcgtg gtgtgctccc cgccggccgc cgacggtgcc tcgctcaccc gcgcgctgac
    30781 cgacgccctc gaagaggagg acctcgaccg gccgttgacg tcgctggagc gcgaagtgac
    30841 gtacgtggtg ctgaaggaga acggcgtgct cgtccccgag gacctccggg gcccgacgac
    30901 catcagggag tgggtgacat gggcgctctc ggagcatggc tgacgcaggc cgcacccgtg
    30961 ctgcgcggct cccgcgcggg cgtggtgacc gagcgcggac ggttctcctg gccgtcgctg
    31021 ctggcgcggg ccgaggagtt ggtggcggag ctgcccgacg cgccgcacgg ctgggtcgtc
    31081 ccctcggacg gcggcgaacg gtcgatcgtg gggctgctcg cgctcggcct gctggacccc
    31141 gcgccccgct gggtgctggg tgacccggct cggtggggcg ccgccggaca cgctcccgtg
    31201 ggcgacggcg ccctgctggc ggccgggccg caggcggcac caccgcccgg cgtggacggc
    31261 cccacctacg ccacggcgtc gtcgggcacc accgggcggc cgaaactgct cttcggccgg
    31321 ccgcacgcgg tggcgtccgc agtggagttg tacgtcgacg gcctgccgga gtacgcctcg
    31381 gccgaggtgt tcgccacctg ctccgcgatc gatttcgcgg cggccttcta catggtggtc
    31441 gcgccggcca tgatgctcgg ccgcgacctg gtgctgttcc ggccgagtgg gtgggagacg
    31501 gcgatccccg agctggccgg gcggccgggg gtgtgcctgg cgccgccggc gctcaccgtg
    31561 ctgggcgccc ggaccgcggc cgggcaacgc gccttctccc acacgtgttt cgtccccgcc
    31621 ggcggtggcc tcaccccgga gcgggcggag cgcatcagca cgggattccc cggcagcgga
    31681 ttcctcacca tgctcggttc caccgagacg ggactcgtca ccgtcgaccg tgcggtgcac
    31741 gacgacggct acgtgggagc gccgctgccg ggcaagccgg tgtggctgga ggacatcggg
    31801 ccggacgggg tcggcacgct gtggacccgc ggccccgaca cccggttcgc ggtgaccggc
    31861 ggacggctga cgacccggcc ggacggcgcg gtgaccaccg gtgatctcgc ccatccggcc
    31921 gacggcggct tcgtcctgga cggccgcaag gacgacttgg tcaaggtcga cggcgtcagt
    31981 gtctacccgc ggcagatcac cgccgccgtg cgggcgctgc ccggcgtcac ggacgcctcg
    32041 gtggcggtcg accgctcccg gaccggcgat cgcctgaccg tcatcgcggt gggcgacgtc
    32101 accgaagccc gggtccgcga cgcctgccga cgactccccg cccccgtgac accgcaccag
    32161 gtcgtctgcc ggccggccga cgaggccgcc tatgacgcac gcggcaaggt gcttcgctga
    32221 gaaagagcgt gatggcatga cgaccggacc cactcgtgcg gcagtcaccg aggcattgct
    32281 gaggtgcccg gccccgctct acgcacgcat gcaccgccag gggcccctgg tgtggagccg
    32341 acccgaccgg acctgggtgg tgaccggcta cgacctcgcg cggctggtgt tacgcgatcc
    32401 ccgcttccgc ctgcccggcc cgccaccgga gtcggagtgg tcggagaacg gcagccacgc
    32461 gggcttcttc cagagcatgt tgctggcctc ggagggagaa cgccacgcgc gcctgcgccg
    32521 cttcctcgga cggctcttca cccctcgggc ggtgcgcgcc cggaccgttc ggatcgaggc
    32581 cgccatggcg gcgctcctgg acgacgccgg ccggtgtccg accatggacg gcgtcgccgg
    32641 gatcagcgcg cgcctgccgg tgagcgtgat cggcgacctc gtcgggatcc ccgaagacga
    32701 ccgccacgag gtcagtgagc tctgccgagt gatcagcagg ggcggcggcg tggcgtcggg
    32761 acggccctcc ggggacgacg tcggcaacgc gctggcgcgg gtggacgacc tcggccggct
    32821 cgtccagcgg tggagggcca ccccggaccg cctgatgccc gactcggtgc tggcactcgc
    32881 cgtcgacgcg cgggacacct cggaggcgct gtccgacacc gaggtcctcg ccaacgtctt
    32941 cagcctctac atcgccggcc acgacacctc ccgcaacatg ctcagcggct tgctgctgcg
    33001 cctggccacc caccccgagc tgctggcggg cctgtcggcc ggcgaggtcg acacctcggc
    33061 ggaggtcgac cggctcctgc tgggcgaatc cccgctcacg ttcaccgtcc gggtggcaca
    33121 ggaggagtgc accctcgaag gggagcgcat ccgccccggc gacatgatca gggtgatgct
    33181 cggcgcggcc aaccacgagc tgctcaccag cggcgcgcag gccgaccacg cgggggtcag
    33241 cttcggcgag ggacgccacg tgtgcctcgg cgcgcacctg gcgcgtaccg agggccgggt
    33301 gttgctggaa gcggtcggcc ggcggtggtc cgggctccgg ctcgcggccg agcccgcctg
    33361 gacgccgcac ttcctccacc ggggactgga cagcctgccg ctggagatcg aatggcggca
    33421 gtgagcggga acgacgcacc accgcccacc gaccgcgtca ccctgggccc ggtcgcggtg
    33481 cgccggcgct gccggctgcc cggttccgtc gtggtggatc tgggcagcga cggggtgtgg
    33541 caggcggccg gagcatgggc cgctgccgag gacgccgccc accgccgcgg cgccgtgctc
    33601 gccgaccacc tcggcacgct ggtgccgacg gtgcgtcagg agcagcgccg ggacgtgctg
    33661 cgggcgcggc gcgccgcgtt caacgcccgg ccgctcccgg cggggctgcc ggtggacgcg
    33721 gccaccgccg accggatcgc ggcgtacaca cgcaccctgg cgtcccgcga cacgtccgaa
    33781 cgagagctcg gcctggcctt ggggaaactg gccgagaccg ccggcgcgac cgtggacgcg
    33841 gcgctgcgcg aggaggacat cgcctggtcc gtcgagctgt cggtgcccgg cctgctggcc
    33901 gccggaccgg tcggcgtgct ggacgcgacc gcgggcaaga aggcccggcg cagggccctc
    33961 acgctgctcc gcctggtgca ccgcgccgcg accaagccca cgccgttcgc cggtttcgcc
    34021 accaccgacg tgctcttccg gggcgctgcg acgaccccgc cgcgcaccca cgtgcgggtg
    34081 gatcgcgccg tggtcgagtg ggtgcggcag tggatcgcca ccggcggcta ccggagcctc
    34141 aggccggagc tgctgtggct caccgtcaac ccgagcgcgg cggtccggga acaccccgac
    34201 ggcctgcggg tgacctggct ggtgaacgcg gcgaacggca ccgagcgggt gcggtccgcg
    34261 cggtgcggag cggcgcttgc cggcacgctg caccagttgc gggacccggt ccgcctggac
    34321 accgtcgcgc ccggtggcgc gctgcccgac acgcttgcgc gtctcatcga gcgcgggctg
    34381 ctggaggccg gaccacgcct gccgagccac ggccggcgga cgctgtgcgc ggtggccggc
    34441 gccacggtcc cggcgccggg cgccgagggg gaggaggccc ggcgggccca ggacgtgcac
    34501 gacgcgctct gcgcgctgcg cgacgcggag gacgccctcg ccaccgccgg tgcggcgcgc
    34561 accgccgcac tgcgcggcgc gaaggagggg atcgctgccc tcgcccacac cctggggacc
    34621 ggcgtccggg cggccgaccg tgcgacggtc agtgcggacg tcgtgggcgt ccgggccgac
    34681 gacggcatcc tgcggacctc ccccgaggtc ctcgccgacc tgggccgggt ccagcgcatc
    34741 gtgccgttgc tcggcttcga gctgcccttc caactggcca ccggcatcgc gttccggcgc
    34801 cgcttcgggt cggatccggt gccggtgccg acggcgtacg cgtggttcct cgacgcgggc
    34861 cgcaaggaag ccgatgcgct gctcgccgac tgtgcggcgg aggagctggc ggcggtgctc
    34921 gccctccgtc aacggctctt cgacgggctg cgcgccgcgg cggaccggcc cggcgcggag
    34981 gtgagctgcg atcccggcct gctggacgcg gtggcggcgg ggctgccgga cgccgtcatg
    35041 gacctcccgt gcgcggcgtg gccggtacaa ctcgccgggg accatgtggt ggtcaacggc
    35101 gtcggcaccg gctacggacg ctttgccgcc cgggtcgccg ccgacctcga cgcgtcccgg
    35161 atcgccgagt tgcgcgcgtg ggcggcgcgc gcggatacgc cccaggaggg cggaatcccg
    35221 gtcgacgtct ccgcgttgct cggggccacg gtcaatgagc acccgctgtt gctgcccgcc
    35281 gcgctgagct atccgggacg ggcgctggag tgtgaccccg aggctcgcat cgacctgtcc
    35341 gcctgtgtcg cgcaggcggt ggggggccgg atgctgctgt tcagcgaccg cttcccggga
    35401 cgaccgctgt tcccggtccc gcacaactcg accctggcca ccgtggcgcc cggactgtac
    35461 cggtggctga gccgcttcgg gccggcgtcc ggcgcgacgc tcacgctgtg ggatcacgtg
    35521 gacgccctgg cggcgccgga gtcctcggcc accgtccgcc actacccgcg gctgaccctg
    35581 ggccacctcg tcctgagccg gcgcacctgg aaggtccctg gcgccgcgct ccccggcggg
    35641 acgtgggcgg ggacggccca gggggcgctg gcctggcacc gctggtgcgc gcgaacgggc
    35701 gtgccccgcc ggtcgtttct gcgcaccacc acgctcccgg acccctggga cgtggtgcgc
    35761 ggccgggccg acaagagccc ggtgatggcc gcccgttccg cctccggcgc ggggatccgc
    35821 aagcccctgt acgtcgacct gtcccagccc ctgtgctggc cggccgcggc ggttgccccg
    35881 ggggacaccc tgaccttcac cgaaccgctg cccgacccca tcgacgccga ccccgacggt
    35941 cgcgtcaccg agtacgtcct ggagacctcc cagcccccgc gcgtatcgac cgcgggcggc
    36001 gccggcgccc ggccgtaaga aggaagccaa tggcacacaa aggcatcatt acgctgatca
    36061 accccaacca aatttatcca cctatcgcgc cctatgcact ggacgtcttg accacggcgc
    36121 tggaggccga gggattcgaa acgcacgtac tggatctcac gttccatgtg ggcgactgga
    36181 aacaagcgct ccgggattac ttcgacagca gccgcccctt gctggtcggc gtcacgtgcc
    36241 gcaataccga caccgtgtac gcctttgaac aacgcccgtt catcgatggg tacaaggcgg
    36301 tcatcgacga ggtccgcggg ctgaccgcgg ctcccgtcat cgccggtggc gtggggttct
    36361 ccaccatgcc gttcgccctg gtcgactact tcgacgtcga tttcggtgtg aagggtccgg
    36421 gcgagaagat catctgcgac ctggcacagg ccttcgtcga ggggcggacc gccgaccaca
    36481 tcccgggact gctcatcaac cgcggccccg ggcaggtcac cagggtgccc ccgcccgtgc
    36541 tgaacggacg cgcggcggct gctcccgcgc ccgtggcggc ccccgcaccc ttgccggccc
    36601 ccgcgcccct gtcgttcggc gccgtcggcc gttacgagag ccgggcgtgg caggcggaga
    36661 ccgaacgctc ctacacccgg cggtccggcg agccgtacaa gatcgacaac ctgcgctact
    36721 accgggaggg ggggctgggc agcatcctga ccaagagcgg ctgcgtctac aaatgcagcc
    36781 actgcgtgga accggacgcc aagggcacgc agttcgcgcg ccgcggggtg gccgcggtgg
    36841 tggacgagat ggagtcactg accgcccagg gcatctacga cctgcacacc acggacagcg
    36901 aattcaacct ctcgatctcc cacagcaaga gcctgctgcg ggagatcatc cggcgccggg
    36961 agggtgaccc ggccagtccg ctgcgccacc tgcggctctg ggtctactgc cagcccgcgc
    37021 ccttcgacga ggaattcgcg gagctgctgg cggccgccgg ctgtgcgggg gtgaacgtcg
    37081 gcgcggacca cgtacgcccc gagatgctcg acgcgtggaa ggtgaccgga aagggcacgc
    37141 gctactacga cttcagcgac acggtgcggc tggtggagct gagccaccgc tacggaatgc
    37201 tgacgatggt cgaggcgctg ttcggcatgc cgggagaaaa cctgtcgacc atgcgcgagt
    37261 gcgtcgaccg gatgatggcg ctggacgcga cggtcaccgg cttcagcctc gggctccgcc
    37321 tgtttcccta catggatctg gcgatctctc tggccgagaa gtgtgacggg gtccgcacgc
    37381 tccccggact gcagtccaac aacgcgaccc ggccgatcgt cctgaagccg ctgcggaaat
    37441 gcagcagccc catcgagtac gaacggcaat tcatgttcga cgaatccggg gagttccggc
    37501 tggtctgcta cttctcgccg gacctcccgg aagctccggg aacagtgggc agcccgcacg
    37561 ggatatggca ggcctctgtc gatttcctct gggaccacat tccgaagtcc gaatactatc
    37621 gagtgatgct gccgaccatc tccggcagca gtgagaacga caacaattac gccgacaacc
    37681 cgttcctcac cagcctgaac aggcaggggt acaccggcgc tttctgggcg cactggcgcg
    37741 accgcgaggc catcatgagc ggtaccggcg ccctcgggga gctcgcggtg gaggcggccc
    37801 ggtgagcgct gaactcccct ccctgcgcgg gcaggcggcg ctgatcaccg gcgcgggccg
    37861 cggcctcggc agcatcctcg ctgccggact cgccgaagcg ggcatggcgg tcgggctgat
    37921 cgggcgcaac cggcggcggc tggacgacac cgcacgtgcc tgcgcacggc acggggccgc
    37981 caccgccgtc tgcgtggcgg acgtccgttc cccacgggag atccgggaag ccgcccgggc
    38041 ggtgcatgcc gaactggggc ccgtcgacct gctggtgaac aacgccgggc tggtggacca
    38101 gggcgaggcc cccttctggg aagccgaccc cgagcactgg tgggaggtct tcgaaacgaa
    38161 cgtccgcggc accgtcaacg cctgccaggc ggtgggacag gagatgatcc ggcgccggtc
    38221 gggccggatc gtcaacgtca actccatctt tgcggtgcag ggggacctgc gctactccgc
    38281 ctacagcggt tccaaggcat ccctgctggc cctcgccgct gtcgtggccg acccgctcag
    38341 ggaccacggg gtccacctct tcgacatcag ccccggcatg gtgcgcaccg acatgacgct
    38401 ctccatggcc gtctgcgcgg gccgtgagga ctggacggac cccgcccgtt tcgtggcggc
    38461 ggtgctccgc gtggcgcgcg gcgagctgga tccgctcgcc ggacgctttc tgcacgtggg
    38521 gaccgacgac ctcgatgagt tgctcggccg gcagcaactc accggctgac ggcgaaattc
    38581 cgctatc
//
