LOCUS       BGC0000613             15586 bp    DNA     linear   BCT 01-JUL-2009
DEFINITION  Nonomuraea sp. Bp3714-39 thiomuracin gene cluster, complete
            sequence.
ACCESSION   BGC0000613
VERSION     BGC0000613
KEYWORDS    .
SOURCE      Nonomuraea sp. Bp3714-39
  ORGANISM  Nonomuraea sp. Bp3714-39
            Bacteria; Actinobacteria; Streptosporangiales; Streptosporangiaceae;
            Nonomuraea.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 20:02:25
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..1212)
                     /gene="tpdI"
     CDS             complement(1..1212)
                     /codon_start=1
                     /gene="tpdI"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: PF04055"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 60.5; E-value: 2.1e-18)"
                     /gene_kind="biosynthetic"
                     /note="TpdI"
                     /product="coproporphyrinogen III oxidase"
                     /protein_id="ACS83777.1"
                     /sec_met_domain="PF04055 (E-value: 7.1e-21, bitscore: 65.0,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKPLLIYANVPFCNSKCHFCDWVVQVPVRDLRLGEQSPGRVAYL
                     EAIRTQIRVQAPALREHYHPDIVYWGGGTASILGPHEIESLYGTLSAEFDLSTVREATI
                     EGSPESLDRDKLRLLRELGFNRISIGVQSFDDARLRRLGRAHAADQALTAVQDAHEAGF
                     TNINIDLIVGFPGQTGQEVADSVRTALTLPINHFSIYPYRASPGTVLRKQVHRGAQLDL
                     NLQLQAYGIARELLEAAGFPEYAMSYFGHPRCQSDEAYYQLRMDWIGFGSGANSLIGRR
                     YLSYEKGKLAHYNTNPLAFDINAPAHSPQLTLHFLSQALTTAEGLDARLYQQRTGVPLR
                     TACSHPEVMTYLERMNNHGRLIADHNGIRLHRDDIAQTFIALNWIPTPDTTPNEVIPLT
                     PSPT"
     source          1..15586
                     /clone="BAC ABP003-G24"
                     /db_xref="taxon:653921"
                     /mol_type="genomic DNA"
                     /organism="Nonomuraea sp. Bp3714-39"
                     /strain="Bp3714-39"
     misc_feature    1..15586
                     /note="thiomuracin gene cluster"
     protocluster    1..15586
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[9242:14255]"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      9243..14255
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
     protocluster    1..15586
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[0:14255]"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /neighbourhood="10000"
                     /product="thiopeptide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      1..14255
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /neighbourhood="10000"
                     /product="thiopeptide"
                     /protocluster_number="2"
     cand_cluster    1..15586
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /detection_rules="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /kind="chemical_hybrid"
                     /product="thiopeptide"
                     /product="LAP"
                     /protoclusters="2"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..15586
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000613"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..15586
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="thiopeptide"
                     /product="LAP"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and ((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or PF07366 or PF06968 or PF04055) or thiostrepton)"
                     /rules="((((goadsporin_like or PF00881 or TIGR03605) and
                     (YcaO or TIGR03604)) or TIGR03882 or TIGR03603 or
                     TIGR03602) and not cyanobactin_synth)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1209..2372)
                     /gene="tpdJ1"
     CDS             complement(1209..2372)
                     /codon_start=1
                     /gene="tpdJ1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 384; E-value: 1.2e-116)"
                     /gene_kind="biosynthetic-additional"
                     /note="TpdJ1"
                     /product="cytochrome P450 monooxygenase"
                     /protein_id="ACS83778.1"
                     /sec_met_domain="p450 (E-value: 4.3e-30, bitscore: 94.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPVRPPSVTDGGTSLFAWLREMRDTHPVWRDSYGMYHVFRYDD
                     VRAVLADHERFSSDRTRLMGRQPFGQGGITMIDPPEHRHQRRLITAAFTPSSVAALEPR
                     IAAIADELLDALPGPDFDLVESLAYPLPVTVVAELLGVPPSDRDLFRTWSDRLMSLQVP
                     DFADPSLAGRVAAAMAEMNDYLREHCADRRTRPRDDLLTRLVHAEIDGERLDAEQVVNT
                     ASLLLLAGHVTTTVLIGNTVLCLADAPEAAHRTRADMSLIPQALEESMRLRSPFMQAGR
                     VTTQDVQVAGETIPANRFVMAWLLSANHDERHFADPERFDLDRQLTGQLAFGHGVHFCL
                     GAQLGRLEGRIALERLLSRFTELRPEKRSFYESQIFGVREMHVRGSS"
     gene            complement(2369..3589)
                     /gene="tpdJ2"
     CDS             complement(2369..3589)
                     /codon_start=1
                     /gene="tpdJ2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 370; E-value: 2.3e-112)"
                     /gene_kind="biosynthetic-additional"
                     /note="TpdJ2"
                     /product="cytochrome P450 monooxygenase"
                     /protein_id="ACS83779.1"
                     /sec_met_domain="p450 (E-value: 2.9e-33, bitscore: 104.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNETHVPPDPTMTMPIDSRPRIKDGGQTLLKWLGTMRDEQPVWRD
                     AFGIFHVFRHAAVQRVMSDYAAFSSDINRLRPGGDPFSAGSLMLTDPPEHRKLRKLISQ
                     AFTPKMSSDMVPRIAELTTALLDEIDEDEFDLVEKIAHPLPVMVIAELLGIPIHDRELF
                     RTWADRLVALHVEDPRDIEIGRMVGQAMREMGEYVLTHVRERRTRPQDDLVSRLVAAEV
                     DGDRLTDAEIVNSACLLLLAGQITSTMALGNAFLCFRDAPGVESAVRADRELIAPAFEE
                     VLRLRPPLTQAARLPTADVEIDGTPIPAGSMVINWLLSANYDERQFPDPYRLDPGRQPN
                     RQYAFGHGIHFCLGAPLARVEGKVALELVFDRFEQVEIDPDAELSYYEDPMFGVKSLPV
                     RVKRAPR"
     gene            complement(3600..4331)
                     /gene="tpdR"
     CDS             complement(3600..4331)
                     /codon_start=1
                     /gene="tpdR"
                     /note="TpdR"
                     /product="TetR transcriptional regulator"
                     /protein_id="ACS83780.1"
                     /transl_table=11
                     /translation="MSTVSTRSTGARTSDDRVRRTLDVTRSLLLRSGYKRTTMDEIARR
                     ADIGKGTIYLSWDTKDDLIRTLVIQEIVGVCQDISRIAVLRPAVARLSEFSRELFTLVF
                     KYPLFRALYTYDKETLGRACDDPQLGFQCYRFTTFTPFRDYLRMLHESGMWDPSHGFAL
                     DALLSGFIKLHLHAEIAGAKPDLAAHADSLAGLIRSSFEPADQVPAEELTDPARRTVEI
                     FDGAAAKYRAKLIPQPLAASV"
     gene            4677..4826
                     /gene="tpdA"
     CDS             4677..4826
                     /codon_start=1
                     /gene="tpdA"
                     /gene_functions="biosynthetic-additional (thiopeptides)
                     predicted thiopeptide"
                     /gene_kind="biosynthetic-additional"
                     /note="TpdA"
                     /product="thiomuracin prepropeptide"
                     /protein_id="ACS83781.1"
                     /transl_table=11
                     /translation="MDLSDLPMDVFELADDGVAVESLTAGHGMTEVGASCNCFCYICCS
                     CSSA"
     CDS_motif       4677..4778
                     /prepeptide="leader"
                     /note="peptide class: thiopeptide"
                     /note="predicted sequence:
                     MDLSDLPMDVFELADDGVAVESLTAGHGMTEVGA"
                     /locus_tag="tpdA_thiopeptide"
                     /aSTool="thiopeptides"
                     /tool="antismash"
     CDS_motif       4779..4823
                     /prepeptide="core"
                     /locus_tag="tpdA_thiopeptide"
                     /peptide="thiopeptide"
                     /predicted_class="Type II"
                     /score="27.60"
                     /molecular_weight="1522.8"
                     /monoisotopic_mass="1521.5"
                     /core_sequence="SCNCFCYICCSCSS"
                     /aSTool="thiopeptides"
                     /tool="antismash"
                     /leader_sequence="MDLSDLPMDVFELADDGVAVESLTAGHGMTEVGA"
                     /leader_location="[4676:4778](+)"
                     /tail_sequence="A"
                     /tail_location="[4823:4826](+)"
                     /alternative_weights="1540.8"
                     /alternative_weights="1558.8"
                     /alternative_weights="1576.8"
                     /alternative_weights="1594.9"
     CDS_motif       4824..4826
                     /locus_tag="tpdA_thiopeptide"
                     /note="tail peptide"
                     /note="thiopeptide"
                     /prepeptide="tail"
                     /aSTool="thiopeptides"
                     /tool="antismash"
     gene            4866..7478
                     /gene="tpdB"
     CDS             4866..7478
                     /codon_start=1
                     /gene="tpdB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     29.7; E-value: 2.3e-09)"
                     /gene_kind="biosynthetic"
                     /note="TpdB"
                     /product="dehydratase"
                     /protein_id="ACS83782.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.1e-39, bitscore:
                     124.7, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPFGANKANGAHVMAVIEREESDGPPVAVRTCGVAAAELESLRWD
                     ESYALVTRLLAETARVAADGRRLAVALGDVIGGLGPSGSRPVLVGLRRALHTGRLPSGR
                     EWGPEAGAALPYGLRGEVEEWVRRARECAGLRARLPEVVARESLEKEERLRAAAADPAF
                     RRGLALAGGELAVDLETWLADPARRPKPQKLLRLAKYLVRAAVKTSPYSTFTSTGRAVW
                     GGGERHVERVVPVLELDGVQTFSDDRVRVNPSVTVAGGTAEFIGPPPGEALVSIGVTEA
                     VAACLRVAEGGEWVPRGRFAEALGAEPAAVTKFLDKLLAVGLLEARPDGDPPPHLLDGI
                     RRTERATDPSTFRHELGRLIAAARAAARATAPGADTAKNAAPAGRATRGDGGADAERAT
                     RGDSDADDGRATRGDGGADDRGAARGDGGVGRAVVHEVAVCVEPVARLDPARWRGGLAD
                     LDVVRRWLAVFDAKHPMRLAVAAYLTTRYGPDPAVPFLTLHRHIQRELAGTGAAGRELR
                     AFLGSSAAWTQPLGTSALPRIRELERLRAEARSLALDAEDPDGTCRVTPGQLAAQLESW
                     PSWIAIPASSACYVQAVAGTLVLNVVHGGHGRALRRLDHLLERAGGHPEPPRIEDPDGA
                     VYAEFSGDLGSTLNARPPSTRYEIDYPHSPGTRPPDLRLPLTDLHVTLCPDSGLPELRS
                     KRLGRRVVPLHLGLAAEFRLPPAARFIERVFGPGYLLHPSSPPLVRMGRVPSEVTRYPR
                     VEAGRVVVQRRRWLAPAATLPVRAKGEGDAAYLTRLIAWADEYGVPHRSFVRAWPEQTG
                     DKGQDKARKPLFLDLANLFLVKNFERQIRGCAFALFEEALPDPGPERVTEYLIEVGGR"
     gene            7475..8290
                     /gene="tpdC"
     CDS             7475..8290
                     /codon_start=1
                     /gene="tpdC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /note="TpdC"
                     /product="dehydratase"
                     /protein_id="ACS83783.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.3e-34, bitscore:
                     107.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSWVSVHVFSQGPLDDMITGLAGPLLGDDGFFLRYWEGGPHLRIR
                     VRSHPAEQVVERAEAYLREHPSEAVIDPEEYARLAATLAAREGVPGYTRRLYPNDSAHL
                     IPYQPEHDRYGTGRSLDAVERHFHDSSVIALQLIGAGLGHERRSMAWLTMLLVAWQVAG
                     EGRAFGPPADAGVQVPHERMAALVEHARAVTQEPAPSEPRGVVAAWYASIARLVEELAA
                     AGFDAARTGATVDLAAHLLANRLGIRVQEEARLRHLASGATRESEVGVG"
     gene            8287..9246
                     /gene="tpdD"
     CDS             8287..9246
                     /codon_start=1
                     /gene="tpdD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /note="TpdD"
                     /product="hypothetical protein"
                     /protein_id="ACS83784.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3e-50, bitscore:
                     161.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTWTRLRVDYHDGPMDDLILDALRPAWHEIRGYFLRHWVCGPHLR
                     IFVDGDATPIVRAVERHLAACPSAGTTDPQALLPLHERLAELEGERGPLLPWAPDNTVT
                     AEPPGLDTELDRFLADFYADTTEAAFDALGRVRAGTPLPGIAFDLVVATAHDLSEGGLP
                     TARTSLRSHAEAYLSRLPGGVRAKWQAHYERNQEPLTARIKALTGAGEPGAWLRTIRAT
                     RDRGRTLIDEGRLSLGYATDGPSTRPPLAAVSPFHRNLETDERWLALKDTPAFAAYRLA
                     LNCAYLHLTRLGLTPDQRFLICHLAASAADDVYRAVAS"
     gene            9243..10529
                     /gene="tpdE"
     CDS             9243..10529
                     /codon_start=1
                     /gene="tpdE"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_kind="biosynthetic"
                     /note="TpdE"
                     /product="dehydrogenase"
                     /protein_id="ACS83785.1"
                     /sec_met_domain="PF00881 (E-value: 2.6e-16, bitscore: 49.8,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGERYELRAGVHLARLDAGVRLFAWPHAETLGELTRDELDLLRD
                     LAAGPRTAGGPLVERLRAGGWLKITITRDGVPLYTLAPLRPPPPRPAVPERPVLSRFAT
                     LRREGDALVAGSPLAWCDLYVHDPGLVGDVVRPGGEVLADLVWAGLAVPEEAEDRELRF
                     RQWAPHELEFHDRSRVGHRGYLGDGFGGTFWARGRFDPLPARPRPYPGRAIELPTPDLD
                     ELRLKDPSLTDVLEGRRSVREHDDERPITLDLLGELLYRTARVRECWTADGVEYTRKPY
                     PSGGSVYELEIYPVVRNVAGLEPGMYHYDGHDHVLRPVREAGHPAVRRLLTVAGHGAAT
                     GRRPQVLLAVSSRAGRLLWKYEGMGYALTLKHVGVLYQTLYCVATAMGLAACGLGSGDS
                     AAFAEATGRDPLEECAVGEFMIGTAEAPR"
     gene            10526..12418
                     /gene="tpdF"
     CDS             10526..12418
                     /codon_start=1
                     /gene="tpdF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Heterocycloanthracin_C_RRE"
                     /gene_kind="biosynthetic"
                     /note="TpdF"
                     /product="hypothetical protein"
                     /protein_id="ACS83786.1"
                     /sec_met_domain="YcaO (E-value: 2.1e-10, bitscore: 30.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 1.8e-23,
                     bitscore: 72.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     1.9e-11, bitscore: 33.4, seeds: 5, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDFKPRLPADIRFAPTSGGVAFLTREGVVRMNGASVHLWVERLA
                     VHLDGSRTVAELTAELPDERRAFVTSLLTTLRERGLVEDAGERGVLPVAAGTACSLLAD
                     ADRFGELAPALADALRRLGLEVLTEPSGGALVHVAAADADGLAAAGRLDRLSAERGLPI
                     AHVLLREGEAWWSETGVVGRDVPPWAAGWRRLAAMEAVPRTAGHVSVSPVAAAVVAGQV
                     VADLGRCLSGTPRVSGGPRLHVVDLDGFGMRTHSFLPHLSALPPGTGVSAGPLGEEEFS
                     RRAARLMDSRTGVFAEIEEGEYGQLPLHVSVTTVADPMGALGGALARVIGVGADFATAR
                     YRAALKALTVHGLLALDPRRLVTAEGTPLTGAGEPASGFPADPGARERPIGGFSADPGA
                     GERPDDGLLDDPLVGDVAAGRVEAFVRGRDLVEGGEVLLPARAVFLDPHATGAAAGYSA
                     EEALVAGLLDHCAALAGLDGTLPPVDVGGARAADDETARSAALLDAIGLPYQVLDATGP
                     SGVPVHAGTLGGRLVARAAGVTPLAALRATLEGILAAYQGIPGPAPLPDLCPAVAQEPP
                     VVLDTGAAVLGAGELAAALAGAGLRVSAVPLDHDREVHALMPHVVRVVTEPLHG"
     misc_feature    11921..11923
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12411..14255
                     /gene="tpdG"
     CDS             12411..14255
                     /codon_start=1
                     /gene="tpdG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_kind="biosynthetic"
                     /note="TpdG"
                     /product="cyclodehydratase"
                     /protein_id="ACS83787.1"
                     /sec_met_domain="TIGR03604 (E-value: 9.5e-101, bitscore:
                     326.9, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 4.1e-74, bitscore: 239.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEVVGTGLLAEEITIALKDRDGRAEVTITACDGWARGPRRDGAA
                     WLPVRVEYGVAVIGPLERPGEPGCVTCFETRRDRVRTDSADRAAVLAVHGPELAGRASP
                     YLGRLAARTIAALAAHAAEGPGCAVWYVDLRTLTAERHTFLPEPHCPDCGDLPDDDRAS
                     AAFEPGAAPRPPGYRVRNVPAEHGALLDTYVDGECGLIRPLVRDTLGGLVIAGAMLPLR
                     FEGGSEPGVGRTRGYRASEVTAVLEALERWGGVEPGGKRTRVRASYAEVAADALDPRTL
                     GEHDTSSYEMEGFAFRPFAEDAVCDWVWGYSFARRSPILVPESLAYYYVRGRERPFLFE
                     ISNGCALGGSMAEALLYGLLETVERDAFLMTWYGRLPVPRIDPGTARDRTIPLQAAAII
                     AETGYRVELYDTTMEHGIPSVWAMGVRQDGDPGRPRLVCAAGAHLVPEKAVLSALSELG
                     PLLADLIRRYPDEVHRAQEMVTNPDLVATMHDHSTLYGADAAFDRLSFLTGGTGVRGLP
                     DMEAFTVPGDLDVMRVVDRFLAEGMDVVVIDQTTPEHRARGFSCVKVLVPGTLPMTFGH
                     RNRRVRGLTRPLELPYRLGHRDTPLTPADLNPDPHPFP"
     gene            14252..15586
                     /gene="tpdH"
     CDS             14252..15586
                     /codon_start=1
                     /gene="tpdH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1244:amidohydrolase (Score: 275.4; E-value: 1e-83)"
                     /gene_kind="biosynthetic-additional"
                     /note="TpdH"
                     /product="peptidase"
                     /protein_id="ACS83788.1"
                     /transl_table=11
                     /translation="MTTEPFPAPTGPPAAPTGPSPALAEPSAASPGPLSVRQGPSPVTA
                     ELRDLAIFRADLHAHPELSWQEARTADRLAGRLAAAGYEVTTGMGGHGVVGRLCRGDGV
                     TVMLRAELDALPVKEETGLSYASTATATTLDGRTVPVSHACGHDLHLACLVGAARRLAA
                     CDDWRGTVLVIGQPAEETLEGAAAMLADGLYERFGVPDVALAQHVSPFPAGLIAYPEPP
                     TAAGAELRVVVTGDGGHVGDIGRAGHVDRAVGRNPVAAVAALVHRLDQTAFDQAIVTVG
                     TLHAGERANVIPTLAEAGITVRAATEEAVTRAVARVARLAEETAGAGVIVVSRVPPGVN
                     DPAATALVRRAHEAALGAVVTAPGGSACEDFPLYGVPSVYWYVGAAPPAGLVGRPHTGT
                     FRPDPVPTLRAGVTAMQTAALAVLANASQFAPPSRYHGPGAVAEH"
ORIGIN
        1 ctaggtgggt gagggggtta gggggattac ctcgttgggg gtggtgtcgg gggtggggat
       61 ccagttgagg gcgatgaagg tctgggcgat gtcgtcgcgg tggaggcgga tgccgttgtg
      121 gtcggcgatg agccggccgt ggttgttcat gcgttccagg tacgtcatga cctccgggtg
      181 agagcaggcc gtgcggaggg ggacgccggt gcgttgctgg tagaggcggg cgtccaggcc
      241 ctcggcggtt gtcagtgcct gggacaggaa gtggagggtg agctgtgggg agtgggccgg
      301 ggcgttgatg tcgaaggcca gcgggttggt gttgtagtgg gccagcttgc ccttctcgta
      361 gctcaggtag cggcggccga tcagggagtt ggcgcccgag ccgaagccga tccagtccat
      421 gcggagctgg tagtacgcct cgtccgactg gcagcggggg tggccgaagt aggacatggc
      481 gtattcgggg aagccggctg cttccagcag ttccctggcg atgccgtacg cctggagctg
      541 gaggttgagg tcgagctggg cgccccggtg gacctgcttg cgcagcaccg tgccggggct
      601 ggcgcggtag gggtagatcg agaagtggtt gatgggcagg gtcagggccg tgcggaccga
      661 gtcggcgacc tcctggccgg tctgcccggg gaagccgacg atcaggtcga tgttgatgtt
      721 ggtgaagccg gcctcgtggg cgtcctggac ggcggtgagg gcctggtcgg cggcatgggc
      781 gcggccgagg cggcgcaggc gcgcgtcgtc gaaggactgg acgccgatgc tgatccggtt
      841 gaagcccagc tcgcgcagga ggcgtagttt gtcccggtcg agggattccg ggctgccctc
      901 gatcgtggcc tccctgaccg tgctcaggtc gaactcggcg gacagcgtgc cgtacaggga
      961 ctcgatctcg tgggggccga ggatgctggc cgtgccgccg ccccagtaga cgatgtcggg
     1021 gtggtagtgc tcgcgcaggg cgggggcctg gacgcggatc tgggtcctga tggcctccag
     1081 gtacgcgacg cggcccgggc tctgctcgcc cagccgcagg tcgcgtacgg ggacctggac
     1141 cacccagtcg cagaagtggc acttggagtt gcagaagggg acgttcgcgt agatcagcag
     1201 gggcttggtc atgaggaacc tctcacgtgc atctccctga cgccgaagat ctggctctcg
     1261 tagaaggagc gcttttcggg acggagctcg gtgaagcggc tcagcaggcg ctccagcgcg
     1321 atgcggccct ccaggcgccc gagctgggcg cccaggcaga agtgcacgcc gtggccgaac
     1381 gcgagctggc cggtgagctg ccggtccagg tcgaagcgtt cggggtcggc gaagtggcgt
     1441 tcgtcgtggt tggcggacag gagccaggcc atgacgaacc tgttggccgg gatggtctcg
     1501 ccggccacct gtacgtcctg cgtggtcacc ctgcccgcct gcatgaacgg cgagcgcagg
     1561 cgcatgctct cctccagcgc ctgggggatg agcgacatgt cggctcttgt ccggtgggcg
     1621 gcctcggggg cgtccgccag gcagagcacg gtgttgccga tcagcacggt ggtggtgacg
     1681 tgcccggcca gcaggagcag gctcgcggtg ttgacgacct gctccgcgtc gagccgctcg
     1741 ccgtcgatct cggcatggac gaggcgggtg agcaggtcgt ccctgggacg ggtacggcgg
     1801 tccgcgcagt gctcgcgcag gtagtcgttc atctccgcca tggccgccgc cacccgcccg
     1861 gccagcgacg ggtcggcgaa gtcgggcacc tggagcgaca tgagccggtc cgaccaggtg
     1921 cggaacaggt cgcggtcgga cggcggcacg ccgagcagct cggcgacgac ggtgacgggc
     1981 aggggatagg ccaggctctc gaccaggtcg aagtcagggc cgggcagggc gtcgaggagc
     2041 tcgtcggcga tcgcggcgat gcgtggttcg agggccgcga cggagctcgg ggtgaaggcc
     2101 gcggtgatga gcctgcgctg gtggcggtgt tcgggcgggt cgatcatcgt gatgccgccc
     2161 tggccgaacg gctgccgtcc catcagcctg gtgcggtcgg aggagaaccg ctcgtggtcc
     2221 gccagaacgg cgcgtacgtc gtcgtagcgg aagacgtggt acatcccata ggaatcccgc
     2281 cagaccgggt gcgtgtcgcg catctcgcgc agccaggcga acagggacgt cccgccgtcc
     2341 gtgaccgaag gtggccttac gggggccgtc atcggggcgc ccgcttgacg cgtaccggca
     2401 ggctcttgac gccgaacatg gggtcctcgt agtacgacag ctccgcgtcc gggtcgatct
     2461 cgacctgctc gaaccggtcg aacaccagct ccagcgccac cttcccctcc accctcgcca
     2521 gcggcgcgcc caggcagaag tggatgccgt ggccgaaggc gtactggcgg ttgggctggc
     2581 ggccggggtc gagccggtac gggtcgggga actggcgctc gtcgtagttc gcggacagca
     2641 gccagttgat gaccatggaa ccggccggga tcggcgtgcc gtcgatctcg acgtcggccg
     2701 tggggagccg ggcggcctgg gtgagcggcg ggcgcagcct gagcacctcc tcgaaggcgg
     2761 gtgcgatcag ctcccggtcg gcccgtacgg cgctctccac gccgggcgcg tcgcggaagc
     2821 acaggaacgc gttccccagg gccatcgtgc tggtgatctg cccggcgagc agcagcaggc
     2881 aggcggagtt gacgatctcg gcgtcggtga gccggtcgcc gtccacctcg gccgcgacca
     2941 gccggctgac gaggtcgtcc tgcggacggg tgcggcgctc gcgcacgtgg gtgaggacgt
     3001 attcccccat ttcgcgcatg gcctgaccga ccatccgccc gatctcgatg tcccgcgggt
     3061 cctcgacgtg cagtgcgacc agccggtcgg cccaggtgcg gaacagctcg cggtcgtgga
     3121 tcggaatgcc gagcagctcg gcgatcacca tcacgggcag cgggtgggcg atcttctcga
     3181 ccaggtcgaa ctcgtcctcg tcgatctcgt ccagcagcgc cgtggtgagc tcggcgatcc
     3241 gcggcaccat gtccgacgac attttcgggg tgaacgcctg gctgatgagt ttgcggagct
     3301 ttcggtgctc cggcgggtcg gtgagcatga ggctgcccgc gctgaacgga tcgccgccgg
     3361 gccggagccg gttgatgtca gaggagaacg ccgcatagtc cgacatcacc cgctgtacgg
     3421 ccgcatgccg gaaaacgtgg aagatgccga atgcgtcgcg ccagaccggt tgttcgtccc
     3481 gcatcgtgcc gagccacttg aggagggtct ggccgccgtc cttgatgcgc ggccgggagt
     3541 cgatcggcat cgtcatcgtc gggtccggcg ggacgtgtgt ctcgttcaca attgactcct
     3601 cagacggagg cggccagggg ctgggggatg agtttcgccc ggtatttcgc cgcggcgccg
     3661 tcgaagatct cgacggtacg gcgggcgggg tcggtcagtt cttcggccgg gacctggtca
     3721 gcaggttcga aagagctcct gatgaggccg gccaggctgt cggcgtgcgc cgccagatcg
     3781 ggtttcgccc cggcgatctc ggcgtgcagg tgaagtttga tgaacccgga aagcagggca
     3841 tcgagcgcga aaccgtggga cgggtcccac attccgctct cgtggagcat ccggagataa
     3901 tcgcgaaatg gcgtgaacgt ggtgaagcgg taacactgga agccgagctg tggatcgtcg
     3961 caggcccttc cgagcgtttc cttgtcatag gtgtagagtg ctcggaagag tggatacttg
     4021 aacacgagtg tgaacagctc gcgtgagaac tcggagagcc gcgcgacggc aggacgaagc
     4081 accgctattc gcgaaatatc ctggcagact ccgacaattt cctgaatgac gagcgttctt
     4141 atgagatcgt ctttcgtgtc ccagctgaga taaatggtgc cctttccgat gtccgcccgc
     4201 cgggcgatct cgtccatcgt ggtccgcttg tagccggatc gcaggagcag gctcctggtg
     4261 acgtccagag tccggcgtac gcgatcgtcg ctggtcctgg cacccgtgct gcgtgtcgag
     4321 acggtgctca tggctgggtg gctccttccc cgtaagagct ggtgcgcatg aaccggtatt
     4381 ccctaccggc tagggggatt ttggtgggag atgtgctctg ggcccgtcag agctggagat
     4441 ttcgaagata ttcgaaatgc tcagatttca acagtcaggt gccccctccc tgactggctg
     4501 accgattttc gattttagtc agccagttcg cattcttgac cgcgttccat atgtacacct
     4561 agcgtcggcg atgtcgcaag ggtgttccta taccaggcga tgacctccgt gcgatgcaca
     4621 tcagtgcgtt tgcctggaat gtcgatgggg cgtttacccc cggaaggaga gtccgcatgg
     4681 acctcagcga tctgcccatg gacgtcttcg aactcgccga tgacggtgtt gcggtcgagt
     4741 cccttactgc tggtcacggc atgaccgaag tgggagcttc gtgtaactgc ttctgctaca
     4801 tctgctgctc ctgctcgagc gcctgacgcg gtacgcgggc gtcgccacgg cggcgcccgc
     4861 gcctgttgcc ttttggcgcc aataaagcga atggggctca tgtaatggcg gttattgagc
     4921 gggaagaaag cgacggcccg ccggtcgctg tccgcacgtg cggggtcgcg gccgcggagc
     4981 tggaatccct gcgatgggac gagtcctatg cgctggtgac ccggctgctc gcggagaccg
     5041 cccgggtggc ggcggacggg cggcggctgg ccgtggcgct cggtgacgtc atcggagggc
     5101 tcggcccgtc cgggtcccgg cccgtcctcg tggggctgcg gcgggcgctg cacaccgggc
     5161 gtctcccctc cgggcgggag tgggggcccg aggccggggc ggcgctgccg tacgggctga
     5221 ggggcgaggt ggaggagtgg gtacggcgtg cgcgcgagtg cgccgggctg cgcgcccgcc
     5281 tgcccgaggt cgtcgcccgg gagtccctgg agaaggagga acggctgcgc gccgccgcgg
     5341 ccgaccccgc cttccgcagg gggctggcgc tggccggcgg cgagctggcg gtcgacctgg
     5401 agacgtggct cgcggacccc gcgcggcgcc ccaagccgca gaagctgctc aggctggcca
     5461 aatacctggt cagggccgcc gtgaagacca gcccgtacag cacgttcacg agcaccgggc
     5521 gggcggtgtg gggcggtggc gagcggcacg tggagcgcgt ggtgccggtg ctggaactcg
     5581 acggcgtcca gacgttctcg gacgatcggg tcagggtgaa tccgtcggtc accgtcgcgg
     5641 gcgggacggc ggagttcatc gggccgcctc ccggggaggc gctggtgtcc atcggggtga
     5701 cggaggcggt ggccgcgtgc ctgcgcgtcg cggagggcgg ggagtgggtg ccgcggggcc
     5761 ggttcgcgga ggctctgggg gctgagcctg ccgcagtcac gaaatttctg gacaagttgc
     5821 ttgcggttgg gctcctggag gcccggccgg acggcgaccc gcccccgcac ctgctggacg
     5881 ggatccggcg cacggaacgc gccaccgacc cgtccacctt ccgccacgaa ctcggccgcc
     5941 tgatcgccgc cgcccgcgcc gccgcccgcg ccaccgcccc cggcgctgac acggccaaga
     6001 acgccgcccc tgccgggcgc gccacccgcg gcgatggcgg tgctgatgcc gagcgcgcca
     6061 cccgcggcga tagcgatgct gatgacgggc gcgccacccg gggcgacggc ggtgctgatg
     6121 acaggggcgc cgcgcggggc gacggcggtg tggggcgggc ggttgtgcac gaggtcgcgg
     6181 tctgcgtcga gcccgtggcg aggctggatc cggcgcgatg gcgtggcggg cttgccgatc
     6241 tcgacgtcgt acgccgctgg ctggccgttt tcgacgccaa gcaccccatg cgcctcgcgg
     6301 tcgccgccta cctcaccacc cggtacggcc ccgacccggc cgtccccttc ctcacgctcc
     6361 accgccacat ccagcgcgag ctggccggca ccggcgcggc aggccgggag ttgcgcgcgt
     6421 tcctcggctc gtcggccgcc tggacccagc cgctaggcac ctccgccctg cccaggatca
     6481 gggagctgga gcgcctcaga gccgaggcga gaagcctggc gctggacgcg gaggaccccg
     6541 acggcacctg ccgcgtcacc cccggacagc tggccgcgca gctggagtcg tggccgtctt
     6601 ggatcgcgat ccccgcctcc tcggcctgct acgtacaggc ggtggccggc accctggtgc
     6661 tcaacgtcgt ccacggcggg cacggccgag ccctgcgcag gctcgaccac ctcctcgaac
     6721 gcgccggcgg ccaccccgag ccgccccgga tcgaggaccc ggacggcgcg gtctacgccg
     6781 agttctccgg cgacctgggc tccacgctca acgcgcgccc gccgagcacc cgatacgaga
     6841 tcgactaccc ccactcgccc ggcacgcgcc cgcccgacct gcggctgccg ctcacggacc
     6901 tgcacgtgac gctctgcccg gacagcggcc tgcccgagct gcgttccaag cggctcggcc
     6961 gccgggtcgt gccgttgcat ctcgggctgg ccgccgagtt ccggcttccg ccggccgcgc
     7021 ggttcatcga acgcgtcttc ggccccggct acctgctcca tcccagctcg ccgccgctgg
     7081 tgcggatggg ccgggtcccc tcggaggtca cccggtatcc acgcgtcgag gccgggcgcg
     7141 tggtggtgca gcggcgtcgc tggctggcgc ctgcggccac gctgccggtg cgcgcgaagg
     7201 gcgagggcga cgcggcgtac ctcacgcggc tgatcgcctg ggcggacgag tacggcgtac
     7261 cgcaccgatc gttcgtccgc gcctggccgg agcagaccgg cgacaaaggg caggacaagg
     7321 cgcgcaaacc gctcttcctg gacctggcga acctgttcct ggtcaagaac ttcgagcggc
     7381 agatacgtgg ctgcgcgttc gcgctcttcg aggaggcgct gcccgacccg ggaccggagc
     7441 gggtgaccga atacctgatc gaggtgggag gccgatgagc tgggtgagcg tgcacgtctt
     7501 ctcgcagggg ccgctcgacg acatgatcac gggcctggcc gggccgctcc tcggcgacga
     7561 cggcttcttc ctgcgctact gggagggcgg cccgcatctg cggatcaggg tcaggtccca
     7621 cccggcggag caggtcgtcg agcgggccga ggcgtatctg cgcgagcacc cgtcagaggc
     7681 ggtgatcgac ccggaggagt acgccaggct cgccgcgacc ctcgccgccc gcgaaggcgt
     7741 ccccggctat acgcggcgcc tctatccgaa cgactccgcc cacctcatcc cgtaccagcc
     7801 ggaacacgac cgctacggca cgggccgctc gctcgacgcc gtggagcggc acttccacga
     7861 ctccagcgtg atcgcactcc agctgatcgg ggcggggctc ggacacgagc ggcggagcat
     7921 ggcgtggctg accatgctgc tggtcgcctg gcaggtcgcg ggggagggca gggcgttcgg
     7981 cccgcccgct gacgccgggg ttcaggtgcc ccacgagcgg atggcggcgc tggtcgagca
     8041 cgccagggcg gtgacacagg agcctgcgcc gagcgagccc cgtggcgtgg tggccgcctg
     8101 gtacgcctcg atcgcgcggc tggtggagga actggcggcg gcggggttcg acgcggcgcg
     8161 gacgggggcg accgtcgatc tggccgcgca tctgctggcc aacaggctgg ggatccgggt
     8221 gcaggaggag gcccggctgc gtcacctggc gtccggggcc acgagggagt cggaggtggg
     8281 ggtcggatga cctggacgcg gctgcgggtg gactatcacg acggcccgat ggacgacctc
     8341 atcctggacg cgctccgccc ggcctggcat gaaatacggg gatatttcct gcgccactgg
     8401 gtgtgcggcc cgcacctgcg gatcttcgtg gacggcgacg cgacgccgat cgtccgggcg
     8461 gtcgagcgcc acctggccgc ctgcccgtcc gccggcacca ccgacccgca ggcgctgctc
     8521 cccctgcacg agcgcctggc cgagctggaa ggcgaacgag gcccgctgct gccatgggcc
     8581 cccgacaaca ccgtcaccgc cgaacccccg gggctcgaca ccgagctcga ccggttcctc
     8641 gcggacttct acgccgacac caccgaggcc gcgttcgacg ccctcggccg ggtcagagcc
     8701 ggcacgccgc tgccgggcat cgccttcgac ctggtggtcg ccaccgcgca cgacctgtcg
     8761 gagggcggcc tgcccactgc caggacctcg ctgcgctcgc acgccgaggc ttacctgtcg
     8821 cgcctgccgg gaggcgtccg cgccaagtgg caggcgcact acgaacgcaa ccaggagccg
     8881 ctgaccgcca ggatcaaggc cctgaccggc gccggagagc ccggcgcgtg gctgcgtacg
     8941 atccgggcca cccgcgaccg gggccgtacc ctcatcgacg agggacggct gagcctcggc
     9001 tacgccaccg acggcccttc cacgcggccc ccgctcgccg cggtctcccc cttccaccgg
     9061 aacctggaga ccgacgaacg ctggctcgcc ctcaaggaca cccccgcctt cgccgcctac
     9121 cgcctggccc tgaactgcgc gtacctccac ctcacccggc tcggcctcac gcccgaccag
     9181 cgcttcctga tctgccacct cgccgcgagc gccgccgacg acgtctaccg ggccgtggcc
     9241 tcatgaccgg ggaacggtac gagctgcgcg ccggcgtgca cctcgcccgg ctggacgcgg
     9301 gggtccgcct gttcgcctgg ccgcacgccg agaccctcgg cgagctcacg cgggatgagc
     9361 tcgacctgct ccgcgacctg gccgccggac cccgcaccgc cgggggaccg ctcgtcgaac
     9421 gcctgcgcgc cggaggctgg ctcaagatca cgattacccg ggacggcgtg cccctctaca
     9481 cgctcgcccc gctgcgcccg ccgccgccac ggccggcggt gccggagcgg ccggttctgt
     9541 ccaggttcgc cacgctgcgg cgcgaggggg acgcgctggt cgccggctcc ccgctggcct
     9601 ggtgcgacct gtacgtccac gaccccggcc tggtcggcga cgtggtccgg cccggcggcg
     9661 aggtcctggc cgacctggtg tgggccgggc tggccgtgcc cgaggaggcc gaggaccggg
     9721 agctgcggtt ccggcagtgg gcgccgcacg agctggagtt ccatgaccgg agccgggtgg
     9781 ggcaccgcgg ctacctgggc gatgggttcg gcgggacgtt ctgggcccgc ggccggttcg
     9841 acccgctgcc cgcccggccc cggccctacc ccggccgggc gatcgagctg cccacgcccg
     9901 acctggacga actgcggctc aaggacccct cgctcacgga cgtgctggag ggccgcaggt
     9961 ccgtacgcga gcacgacgac gagcgcccga tcaccctcga cctgctcggc gagctgctgt
    10021 accgcacggc cagggtgcgg gagtgctgga cggccgacgg cgtcgaatac acccgcaagc
    10081 cgtacccctc cggagggtcc gtctacgagc tggagatcta ccccgtcgtc aggaacgtgg
    10141 ccgggctcga acccggcatg taccactacg acgggcacga ccacgtgctc aggccggtac
    10201 gtgaggccgg ccatcccgcc gtacgccggc tgctgaccgt cgccgggcac ggcgccgcca
    10261 ccggccgccg cccccaggtc ctgctcgcgg tctccagccg cgccggccgg ctgctgtgga
    10321 agtacgaagg catggggtac gcgctgacgc tcaagcacgt gggtgtgctc taccagacgc
    10381 tctactgcgt ggccacggcg atgggcctgg cggcctgcgg gctcggcagc ggcgactcgg
    10441 ccgcgttcgc cgaggcgacc gggcgggacc cgttggagga gtgcgcggtc ggcgaattca
    10501 tgatcggaac cgcggaggca ccacgttgaa cgacttcaaa cccagactcc ccgcggacat
    10561 acgcttcgcg cccacctccg gcggtgtcgc cttcctcacc cgcgaaggcg tcgtgcggat
    10621 gaacggggcc tccgtccacc tgtgggtgga gcggctggcc gtgcacctcg acgggagcag
    10681 gaccgtggcc gagctgaccg cggagctgcc cgacgagcgg cgggcgttcg tgacgagcct
    10741 gctgaccacg ctgcgcgagc gcgggctcgt ggaggacgcg ggagagcgcg gcgtgctgcc
    10801 cgtggcggcc ggcaccgcgt gctcgctgct ggccgacgcg gaccggttcg gcgagctggc
    10861 gcccgccctg gccgacgccc tgcgcaggct ggggctggag gtgctgacag agccgtcggg
    10921 cggggcgctc gtgcacgtcg cggcggccga cgcggacggg ctggccgccg ccgggcgcct
    10981 cgaccggctg agcgccgagc gcgggctgcc catcgcgcac gtgctgctgc gcgagggcga
    11041 ggcgtggtgg agcgagaccg gcgtcgtcgg gcgcgacgtc ccgccgtggg cggccgggtg
    11101 gcggcggctg gcggccatgg aggccgtccc gcgtaccgcc gggcacgtct ccgtgtcgcc
    11161 cgtcgccgcg gccgtggtcg ccgggcaggt ggtggcggac ctggggcgct gcctgtccgg
    11221 aacgccccgc gtgtccggcg gtccgcggct gcacgtggtg gacctggacg ggttcgggat
    11281 gcggacgcac tccttcctgc cgcacctgtc ggcgctgccg cccggcacgg gggtgagcgc
    11341 ggggccgctc ggcgaggagg agttctcgcg gcgggcggcc aggttgatgg actcgcggac
    11401 gggggtgttc gccgagatcg aggaggggga gtacgggcag ctcccgctgc acgtgtcggt
    11461 gaccacggtg gccgatccga tgggggccct cgggggtgcg ctggcgcggg tgatcggcgt
    11521 gggggcggac ttcgccaccg cgcgataccg ggcggcgctt aaggcactga ccgtgcacgg
    11581 gctgctcgcc ctcgaccccc gccgcctggt cacggccgag gggacgcccc tgaccggcgc
    11641 gggggaaccc gccagcggct tcccggctga tccgggcgcg agggaacggc cgatcggtgg
    11701 cttttcggct gatccgggtg cgggtgagcg gccggacgac ggtctcctgg acgacccgct
    11761 ggtgggcgac gtcgcggcgg gacgggtcga ggcgttcgtg cgcggccgtg acctcgtcga
    11821 gggcggtgag gtgctgctgc ccgcccgcgc ggtgttcctg gatccgcacg ccaccggggc
    11881 cgccgcgggg tactcggccg aggaggcgct ggtcgcgggg ttactggacc actgtgcggc
    11941 actggccggg ctcgacggga cgctgccgcc cgtggacgtg ggcggcgcgc gggcggccga
    12001 cgacgagacc gcgcggtcgg cggcgctgct ggacgcgatc gggctgccgt accaggtgct
    12061 ggacgccacc ggcccgtcgg gcgtgcccgt gcacgcgggg acgctcggcg ggcggctggt
    12121 ggcgcgggcg gcgggcgtca cgcccctggc cgcgctgcgg gccacgctcg aagggatcct
    12181 ggccgcgtac cagggcattc cgggccccgc acccctgccc gacctgtgcc cggccgtcgc
    12241 gcaggagccg ccggtcgtcc tcgacacggg ggcggccgtg ctcggcgccg gtgagctcgc
    12301 cgccgccctg gccggcgccg ggctgcgggt cagcgccgtt ccgctggatc acgaccggga
    12361 ggtacacgcg ctcatgccgc acgtcgtccg cgtcgtcacg gagccgctcc atggctgagg
    12421 tcgtggggac gggcctgctg gccgaggaga tcacgatcgc gctgaaggac cgcgacgggc
    12481 gggcagaggt gacgatcacc gcctgcgacg gctgggcgcg cggcccccgg cgcgacgggg
    12541 cggcgtggtt gcccgtgcgg gtcgagtacg gggtcgccgt catcgggccg ctggaacgcc
    12601 ccggcgaacc cggctgcgtg acctgcttcg agacccgccg ggaccgggtc aggaccgaca
    12661 gcgccgatcg ggccgccgtc ctggccgtcc acggccccga actcgccggg cgggcctccc
    12721 cgtacctcgg ccgcctggcc gcccgcacga tcgcggccct ggccgcgcac gccgccgagg
    12781 gccccggatg cgccgtctgg tacgtcgacc tgcgcacgct caccgccgaa cgccacacgt
    12841 tcctgccgga accccactgc cccgactgcg gcgacctgcc ggacgacgac cgcgcgtccg
    12901 ccgccttcga gcccggcgcc gccccgcgac ctcccggcta ccgggtcagg aacgtgccgg
    12961 ccgagcacgg cgcgctgctc gacacgtacg tggacggcga atgcgggctg atcaggcccc
    13021 tcgtccggga cacgctcggc ggcctggtga tcgccggggc gatgctgccg ctgcggttcg
    13081 agggcggttc ggagcccggc gtgggccgca cccgcggcta ccgggccagc gaggtcaccg
    13141 ccgtgctcga agcgctcgaa cggtggggcg gcgtcgagcc cggcggcaag cgcacccgcg
    13201 tgcgggcctc gtacgcggag gtggccgcgg acgcgctcga ccctcgaacg ctgggcgagc
    13261 acgacacctc ctcctacgag atggaggggt tcgcgttccg gccgttcgcc gaggacgccg
    13321 tctgcgactg ggtgtggggg tactccttcg cccggcgctc gccgatcctc gtgccggaga
    13381 gcctggccta ttactacgta cgggggcggg agcggccgtt cctcttcgag atctcgaacg
    13441 ggtgcgcgct cggcggcagc atggcggagg ccctgctcta cgggctgctg gagacggtcg
    13501 agcgggacgc ctttctcatg acctggtacg ggcggctccc ggtgccgcgg atcgaccccg
    13561 gcacggcacg ggaccgcacc atcccgctcc aggccgccgc gatcatcgcg gagaccggtt
    13621 atcgggtgga gctgtacgac acgacgatgg agcacggcat ccccagcgtg tgggcgatgg
    13681 gcgtgcggca ggacggcgat ccgggcaggc cgcgcctggt gtgcgccgcc ggggcccacc
    13741 tggtgccgga gaaggccgtg ctcagcgcgc tgagcgagct ggggccgctg ctggccgacc
    13801 tgatccggcg gtatccggac gaggtgcacc gagcccagga gatggtgaca aatcctgatc
    13861 tggtggcgac gatgcacgac cactccaccc tgtacggcgc cgacgcggcc ttcgaccggc
    13921 tctcgttcct gaccggcggc acgggcgtgc gggggctgcc cgacatggag gcgttcaccg
    13981 tgcccggtga tctcgacgtc atgagggtgg tggaccgctt cctcgccgag gggatggacg
    14041 tcgtcgtcat cgaccagacc acgccggagc atcgggcccg cggtttctcc tgcgtcaagg
    14101 tgctggtgcc cggcacgctc ccgatgacct tcggccaccg caaccgcagg gtgcggggcc
    14161 tgacccgccc gctggagctg ccgtaccggc tcggccaccg cgacacgccc ctgacccccg
    14221 ccgacctgaa ccccgaccca caccccttcc catgaccacc gagccgtttc ccgcgccgac
    14281 ggggccgccc gcagcgccga cggggccgtc tcccgcgctg gcggagccgt ctgctgcatc
    14341 gcccggcccg ttgtccgttc ggcaggggcc gtctcctgtg accgccgagc tgcgtgacct
    14401 ggcgatcttc cgtgccgatc tgcatgccca ccccgagctg tcctggcagg aggccaggac
    14461 ggccgatcgc ctggcggggc ggctggcggc ggccgggtac gaggtcacga ccgggatggg
    14521 cggtcatggg gtggtcggga ggctgtgccg tggcgacggg gtcacggtca tgctcagagc
    14581 cgagctggac gccctccccg tcaaggagga gaccggcctg tcatacgcca gcaccgccac
    14641 cgccacgacc ctcgacggca ggacggtgcc ggtctcccac gcctgcggcc acgacctcca
    14701 tctcgcctgc ctggtcggcg ccgcccggcg gctggccgcc tgcgacgact ggcggggcac
    14761 ggtgctcgtg atcggccagc ccgccgagga gacgctggag ggcgccgccg cgatgctcgc
    14821 cgacggcctg tacgagcggt tcggcgtccc ggacgtggcg ctggcccagc acgtctcgcc
    14881 gttccccgcg ggcctgatcg cctacccgga gccgcccacc gcggccggcg ccgaactccg
    14941 cgtcgtcgtc acgggggacg gcggccacgt cggagacatc ggccgggctg gtcacgtcga
    15001 tcgagccgtg gggcgcaatc cggtcgcggc cgtcgccgcg ctcgttcacc ggctcgatca
    15061 gacggcgttc gaccaggcga tcgtcaccgt ggggacgttg cacgcgggcg agcgcgccaa
    15121 cgtgatcccc accctcgccg aggccgggat cacggtcagg gccgcgacgg aggaggcggt
    15181 gacccgggcc gtcgcccgcg tcgcccggct ggcggaggag acggcgggag ccggcgtcat
    15241 cgtggtctcc agggtgccgc ccggcgtgaa cgaccccgcc gccaccgccc tggtacgccg
    15301 ggcccacgag gccgcgctcg gcgcggtcgt caccgccccc ggcggctcgg cctgcgagga
    15361 cttccccctc tacggggtgc cctccgtcta ctggtacgtg ggcgcggccc cacccgccgg
    15421 cctggtcgga cgcccgcata ccgggacttt ccgccccgat cccgtgccca cgttgagggc
    15481 aggggtcacc gccatgcaaa cggctgccct ggcagtcctt gcgaacgcgt cacagttcgc
    15541 ccctccatcc cgatatcatg gacccggagc agtagccgag cactga
//
