Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000613.1:
Cluster 1RiPP115586

BGC0000613, thiomuracins biosynthetic gene cluster from Nonomuraea sp. Bp3714-39. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: thiomuracin
SMILES string: Copy to clipboard
Molecular formula: C59H50N14O12S6
Molecular activity: Antibacterial
Molecular target: EF-Tu

Class-specific details

Biosynthetic class(es):
RiPP
RiPP subclass:
Thiopeptide (cyclic)
Peptides in this cluster:
ACS83781.1
RiPP core peptide sequence(s): SCNCFCYICCSCSS
Leader peptide length: 34
Follower peptide length: 1
Peptidase(s) involved in precursor cleavage: acs83788.1

Gene cluster description

thiomuracins (BGC0000613). Gene Cluster 1. Biosynthetic class = RiPP. GenBank FJ461360. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Gene expression correlated with compound production, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Esther Schmitt (Novartis Institutes for BioMedical Research)

Literature references

1. Morris RP et al. (2009) Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu. J Am Chem Soc 131(16):5946-55. doi: 10.1021/ja900488a.