BGC0000614: thiostrepton biosynthetic gene cluster from Streptomyces laurentii
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Location: 1 - 29,379 nt. (total: 29,379 nt).
This entry is originally from NCBI GenBank FJ652572.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000614
Short description thiostrepton biosynthetic gene cluster from Streptomyces laurentii
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
FJ652572.1
via
Compounds
  • thiostrepton
Species Streptomyces laurentii [taxonomy]
References
Chemical products information
thiostrepton Evidence: NMR [1], [3]
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C72H85N19O18S5
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACN52311.1
 16 - 1104 (-) TsrV
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    • ACN52310.1
    		 1126 - 1956 (-) TsrU
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      • ACN52309.1
      		 2015 - 3871 (-) TsrT
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        • ACN52308.1
        		 4011 - 4418 (-) TsrS
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          • ACN52307.1
          		 4493 - 5722 (-) TsrQ
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            • ACN52306.1
            		 5924 - 6859 (-) TsrP
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              • ACN52305.1
              		 6930 - 7481 (-) TsrO
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                • ACN52291.1
                		 7900 - 8076 (+) precursor
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                  • ACN52292.1
                  		 8593 - 9384 (+) TsrB
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                    • ACN52293.1
                    		 9377 - 12178 (+) TsrC
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                      • ACN52294.1
                      		 12175 - 13215 (+) TsrD
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                        • ACN52295.1
                        		 13202 - 14308 (+) TsrE
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                          • ACN52296.1
                          		 14305 - 16074 (+) TsrF
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                            • ACN52297.1
                            		 16071 - 17909 (+) TsrG
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                              • ACN52298.1
                              		 17906 - 19951 (+) TsrH
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                                • ACN52299.1
                                		 19929 - 21353 (+) protease
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                                  • ACN52300.1
                                  		 21329 - 22642 (+) TsrJ
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                                    • ACN52301.1
                                    		 22752 - 23942 (+) TsrK
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                                      • ACN52302.1
                                      		 24005 - 26743 (+) TsrL
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                                        • ACN52303.1
                                        		 26760 - 28559 (+) TsrM
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                                          • ACN52304.1
                                          		 28556 - 29374 (+) TsrN
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                                            Biosynthesis information
                                            Annotation changelog

                                            Entry version: next

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2024-05-14
                                            MIBiG v4 annotathon
                                            • (ID: 2A74K4VO5TXJYJJVDDZQ6RUT)
                                            • (ID: U45G63MLSP33JST2JZS23R4V)
                                            • (ID: MGLE5JJ3S32DQA3YR5WPYH4W)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 4

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-10-07
                                            Update chemical activity to schema version 2.11
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 3

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-09-15
                                            Updated bioactivity data
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 2

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2019-10-16
                                            Migrated from v1.4
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 1

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2015-06-12
                                            Submitted
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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