LOCUS       BGC0000614             29379 bp    DNA     linear   BCT 01-APR-2009
DEFINITION  Streptomyces laurentii strain ATCC 31255 thiostrepton biosynthesis
            gene cluster, complete sequence.
ACCESSION   BGC0000614
VERSION     BGC0000614
KEYWORDS    .
SOURCE      Streptomyces laurentii
  ORGANISM  Streptomyces laurentii
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 20:02:31
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 29379
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..29379
                     /culture_collection="ATCC:31255"
                     /db_xref="taxon:39478"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces laurentii"
                     /strain="ATCC 31255"
                     /type_material="type strain of Streptomyces laurentii"
     subregion       1..29379
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="RiPP"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..29379
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             complement(16..1104)
                     /NRPS_PKS="Domain: Aminotran_1_2 (33-329). E-value:
                     1.3e-46. Score: 151.1. Matches aSDomain:
                     nrpspksdomains_ACN52311.1_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 132.9; E-value:
                     2.4e-40)"
                     /gene_kind="biosynthetic-additional"
                     /note="aminotransferase"
                     /product="TsrV"
                     /protein_id="ACN52311.1"
                     /transl_table=11
                     /translation="MTGVTEPGASGPEHRLSLNEMPAVPVTGLDEALRDALRGAHRYPD
                     PFARELTAAIAATHSVPEHDVVTGPGSAVILQHVIQWAAPRRGEVVYARPSFDAYPLAV
                     AAAGATAVEIPLRDHRHDLPRMLAAVTPDTRALVVCNPHNPTGTALGADALLAFLRAVP
                     EHVVVVLDEAYREFAGDKDTLDGPDVYRGLPNVVVLRSFSKAYGLAGLRVGFALARREV
                     ADVLRTRLLPFAVGTVAEAAARTVLARRSEVYARVDRVVAERDRLTAELRGQGWEVAPS
                     AANFCWLPLGSRSAAFVAAAAREGILVRAVAGEGVRVTVGDPAANDAVLRLTARLAKER
                     EEPVGPAASVEGPTEPGEAPGD"
     misc_feature    16..29374
                     /note="thiostrepton biosynthesis gene cluster"
     aSDomain        complement(118..1005)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACN52311.1_Aminotran_1_2.1"
                     /evalue="1.30E-46"
                     /label="ACN52311.1_Aminotran_1_2.1"
                     /locus_tag="ACN52311.1"
                     /protein_end="329"
                     /protein_start="33"
                     /score="151.1"
                     /tool="antismash"
                     /translation="RDALRGAHRYPDPFARELTAAIAATHSVPEHDVVTGPGSAVILQH
                     VIQWAAPRRGEVVYARPSFDAYPLAVAAAGATAVEIPLRDHRHDLPRMLAAVTPDTRAL
                     VVCNPHNPTGTALGADALLAFLRAVPEHVVVVLDEAYREFAGDKDTLDGPDVYRGLPNV
                     VVLRSFSKAYGLAGLRVGFALARREVADVLRTRLLPFAVGTVAEAAARTVLARRSEVYA
                     RVDRVVAERDRLTAELRGQGWEVAPSAANFCWLPLGSRSAAFVAAAAREGILVRAVAGE
                     GVRVTVGDPAANDAV"
     CDS             complement(1126..1956)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /note="putative lipase"
                     /product="TsrU"
                     /protein_id="ACN52310.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 6.9e-15, bitscore:
                     46.7, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 8.4e-21, bitscore: 65.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEETTARRFAGVRHPIHLHVWPPETAPRYLAVFVHGYADHAGRY
                     GRLADALTRHGAAVYAPDHAGSGRSGGARALVTDHDEQVADLATVVERARADHPGLPVV
                     MIGHSVGGMVAVRYAQRHPEDLAALVLAAPVLGSWHTATSLLAFAEIPEMPVDVGSVMS
                     RDPAEAARYNADPLIWHGAFVRDTLESVVTCLERINGGESLAFLPTLWLHGDADPLALI
                     DETRAGVEKIRGFHLAERVYPGALHGLFHDEGRDRATADLTAFLDDALTVPTRP"
     CDS             complement(2015..3871)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177:asparagine synthase (glutamine-hydrolyzing)
                     (Score: 626.8; E-value: 6.4e-190)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative amidotransferase"
                     /product="TsrT"
                     /protein_id="ACN52309.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.1e-90, bitscore:
                     295.2, seeds: 78, tool: rule-based-clusters)"
                     /sec_met_domain="GATase_7 (E-value: 1.4e-45, bitscore:
                     144.7, seeds: 307, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCGIAGWVAFGRDLGAERSAVEAMTRTMACRGPDAGGTWYGGPVA
                     LGHRRLAVIDIAGGAQPMLAEENGQVTAALSYSGEIYGFDELRARLVSAGHTFRTRSDT
                     EVVLRACLEWGEDVTRHLTGMFAFALWDARGQELLLIRDRLGVKPLYYYPTPDGVLFGS
                     EPKAILAHPEARARLTSDGLRELMTWVNTPGHAIFDGMRQVRPGHVVRVARGGITERAY
                     WELPARPHEDDLDTTIGRVRDLLGSSVAGQTVADVPLCSLLSGGLDSSSVAALAVGALR
                     DRGEDPLTCFSVGFSAAGSGPGFVTGPRGGDDSAYAAELARHIGARHEDLTLDAKLLSD
                     PAARAAVLRARDLPQGLADMDTSLYLLFKAIRQRSTVALSGEGADELFGGYPWFHDENA
                     VRAETFPWMYMAGVAAAGGPAFLDPALPERLSLDAYRADRYAEAVAAVPVLPGEAEEDR
                     RMRKVGHLFLTRFLPMLLERKDRMSMAVGLEVRVPFLDHALVEYVFNVPWSMKTFDGRE
                     KSLLRAAMAPELPDSVLTRKKEPYPTIADPAYDQLLKGRLGALMDDTGAPVRALMDEKS
                     AAEAYAAVRKASPEELRFLRVGFESLLKINDWMRDYRVELAE"
     CDS             complement(4011..4418)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: PF07366"
                     /gene_kind="biosynthetic"
                     /note="putative NTF-2 family protein"
                     /product="TsrS"
                     /protein_id="ACN52308.1"
                     /sec_met_domain="PF07366 (E-value: 2.6e-33, bitscore:
                     105.0, seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRASVQQLMEHFLAAYNEGDPRHLDHCLHPEYRHPNPAVERGIE
                     GMRAAIRRWASTVEDLSLTLDDLVVEGDKAVARMTFSGRQVGPILGIPASGRRFSVGLI
                     DIFLIEDGLFAQHWDEMDLLGLHRQLGALPD"
     CDS             complement(4493..5722)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1191:acyl-CoA dehydrogenase type 2 (Score: 188.4;
                     E-value: 2.8e-57)"
                     /gene_kind="biosynthetic-additional"
                     /note="acyl-CoA dehydrogenase family protein"
                     /product="TsrQ"
                     /protein_id="ACN52307.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.4e-14, bitscore:
                     44.5, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.8e-10, bitscore:
                     31.7, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAVFRERAAEHDRTAAFPFRNIDELRAAGYLALTVPRELGGLGG
                     TLADMAVAQERLAAGCASTALAVNMHLSMAGQMARAWRTTGDERARKTLTEIVEGRVIL
                     MGATAEPGHALVRTTGAKARKVEGGYLVTGDKTFGTGSAVMTHMTSMAEYREHPDGPHV
                     LVFRIPADSPGVRVLEGTWNTSGLRATRSENIELRDVMVPEENVLTSYPVGSLDGSLLQ
                     TVWGWAMPTFAAVYLGVAVGAFETCVRDVRSRGWEDRPYIRAEIAACEELIETSRALIE
                     RTAGEVMGNGLWNALTIQQGMARAVLTKNVGTNNAVEIVDRVIRIIGTPALRPGSVYER
                     AHRDVRAGTMHPYSNADACDLIAATTLGEETAPVHPPRLDRLAEPAPEAEAEVEAGAKA
                     SDTAVRPAAS"
     CDS             complement(5924..6859)
                     /codon_start=1
                     /note="putative methyltransferase"
                     /product="TsrP"
                     /protein_id="ACN52306.1"
                     /transl_table=11
                     /translation="MSSLIETAHWIACARAAESLRPDGRLFEDPLAVEFVRRTDPDLYD
                     RLRTEPSSRFDVLAVRTAFFDDRLIRAVTGGPARQVVVLAAGMDGRAFRLPWPPGVTLY
                     EVDLPEGVEEKSAFLSRSGLVADRCRRVPVAADLTGDWPAALAEAGFRPGLPTVWLVEG
                     VLYYLTEAQVDAVVDRVTELSAAGSVLCLEQVNTDLYRAPWMRDWLRQMRDAGRPWRSG
                     VAEPEAWLAGRGWRAEVREPCDLDEAAGRMVPRTPPRGTPGAARTWLVAAELVTGPAVI
                     DSVPDSVPDSVPDSVSDSVSESASASPTVA"
     CDS             complement(6930..7481)
                     /codon_start=1
                     /note="hypothetical protein"
                     /product="TsrO"
                     /protein_id="ACN52305.1"
                     /transl_table=11
                     /translation="MAIPDHRRIDARELARLTMDRPSLTPDRAFWLVDLWIRVQGVVMR
                     PFGVKPNTMRSKREQPLPRVGERLGPYEVFEASEREVLLGDMDKLLEHRMSFIVADGKA
                     YIGVVLRTRNKAGDAYWAQFRHNQTDILHWSLRRGMSRALGIDDEPAATGTPTAPAAPA
                     APAAPPASAAPAVGEATEGR"
     CDS             7900..8076
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: thiostrepton"
                     /gene_kind="biosynthetic"
                     /note="thiostrepton prepeptide"
                     /product="TsrA"
                     /protein_id="ACN52291.1"
                     /sec_met_domain="thiostrepton (E-value: 1.6e-37, bitscore:
                     118.0, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNAALEIGVEGLTGLDVDTLEISDYMDETLLDGEDLTVTMIASA
                     SCTTCICTCSCSS"
     CDS             8593..9384
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /note="putative alpha-beta hydrolase fold protein"
                     /product="TsrB"
                     /protein_id="ACN52292.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 9.4e-16, bitscore:
                     49.5, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPVILVHGLLGTEDAHYAGCRKWWTRPVTEIRLPGHGTGGEIPP
                     HPAAAAIDRVREAIREQPEPPVVVGLSYLGAAVAFRAAAGFPATVAGIVMSGYSFLVSP
                     DTLNRWLAGFTRMASHQPAAQRHFAELHGPTWENLLTATFAELSDGCLRLPGVADLEHL
                     PVPVQLVNGSLLQNERNAIGPAAAAGADVAVIAGAGHVVPMDAPRVFAATVEDFADRVT
                     AGRTAFHERRRAAERAAAEPAVPPEAGTGTEPVARKAATHG"
     CDS             9377..12178
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     21.7; E-value: 6.2e-07)"
                     /gene_kind="biosynthetic"
                     /note="putative lantibiotic dehydratase"
                     /product="TsrC"
                     /protein_id="ACN52293.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4e-12, bitscore:
                     35.4, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSPEITYAGYGVVRVCSQPADIIAQLSSREAARVCDELRDVRRT
                     WQDLAPRVAEELTEVVPLLTDRDERRTVLALRRRLHRAADVPAADLDVLNLAYGTSADG
                     PGAAGTAVAGPLAPGAAALRALAERRDDLAARLEGAYEEGLNAERKVLASAALDPALRA
                     GAQLSADGLLRNMDRYAAAVAEGTAPGKRERMTESTVLHLLTRSTLKPSPFGQLVHTRP
                     VLLPKRATDATPVIAPVTAPGTDEAAERPVSVCRLPRQLVSWVERSLAGRPAFRHVAVL
                     RRAPVVGSSKEGVVFLLRGRDGTHEPAAKERFVRVPPGVVVTAVLALAADAAVPERELR
                     ERCAALPGTDPAAAGAALDALIGQGVLARDLGVGDQHPHPLARLAALLPPDCDAGLRAA
                     VSGLAGAESAFETAGLERREELVSRIKEHVARVAELTGVATPPIDVARTLVYEDAVVAV
                     PRAEAPGRWGRHLPALAPWHRLLPLFDDAAHVRAIVADVVRTHFGPGPHRLLPLFAALS
                     SAKVQAVLTERLTDVSAPLPTRLRTLQDAVFALADPDGGADTVTVDPERAARLADDLPS
                     WIPRWSRASWHVQHHAAPDGGLLVVNGGSIGFGRAISRFLPAYAAAGDAGFGDLVTAEI
                     ARDDDPSAPLTDLAAVLGINANVHSPLLGRHLRYPCATPEEWGGNTGVSLEDCWVVYDA
                     DTGRLLPRLGKDGPVLRLVMLNFLLNELAPRFYQFLNFFSSGSLANLAWWDRVDQRREA
                     GAGADGGAGADGGAGAGGGAGSGTDSVRHYPRVRSGSLVLARRTWKVPDARLPGLAGAT
                     GVAAFAEVRRWQESLGLPDQVFYRGFTLPDPLVPMSREEQRTWARTLARFPTSAERKPT
                     FLDFTSVTSVTAWQRALRRCQGGLTFQECLPAVGEDEGAAGGLRERFTEEFIVETTETE
                     EEG"
     CDS             12175..13215
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /note="similar to lantibiotic biosynthesis protein"
                     /product="TsrD"
                     /protein_id="ACN52294.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.3e-64, bitscore:
                     209.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAPAHPWLSCHVFHHGDTDPLIAECLLPLVDDLRRAGRVERHF
                     YLRHWERGPHVRLRMRVPAEHHDAVRAETERRVLDYLGRRPGPVDTDPARLRDALRRLS
                     ELEHGDASDVAVRTPEPPNSLRWIDYQPELAKYGGPEGVAIAEDVFHAGSVLTGQVLRL
                     VDNDRARMGIALQLLLLASRALGFGPDERAVFLRTYQERWSGYVTDPRVLASWDRQYQL
                     QREQYAALLDGLDAGDPVGKGLGAYWERTLVQALERLRPLVGTGRVWPAETDPAAPPVV
                     ALAALVSQFLHTTNNRMNVRPQGECFVAYLASRAAEDQRAARSGTAPTADPAQTAHERD
                     ERHVHQ"
     CDS             13202..14308
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /note="hypothetical protein"
                     /product="TsrE"
                     /protein_id="ACN52295.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.3e-27, bitscore:
                     87.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTSEQKDLTVSVPWSVQEDLLLDVAAPLLDESVELGETDSWFYL
                     RENHGGRPFLRLRFASRSPSVERRLKSRILAHVGPTIDAGDVFTYQPYNHEHDWLGGTA
                     GLGLAENFWTETTPLALDTLRATRGNRALRLAVAFDFLVCTGVMLAPHLPPSIAKFGYK
                     AGYLSYLATFEGYMLLIRDPEGTRAKHAQRYEKNRELLRPRLRTLVEQMSEPDGELTDV
                     PELAREWLVRLRDYVPALQKGFDEGRFYLYATPRKAETAKLTPSPDGLYRRPDVEWLSD
                     LPEPPVAGIHRAIADNTYYQGMIREDRRFLASRLAQAYTNWHLYRLGFLLADRYTLFYL
                     IARAFEEEYDLDAAALIRSVRPEAEVAG"
     CDS             14305..16074
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_kind="biosynthetic"
                     /note="McbC-like protein"
                     /product="TsrF"
                     /protein_id="ACN52296.1"
                     /sec_met_domain="PF00881 (E-value: 1.1e-08, bitscore: 25.7,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPGTAEATAPVEAAAPAEAAGTGPFDAAGVDGFVRRLRGDFDE
                     VHPDQWQIDWRSIPSPFRWYVDLPRRDLPALSRAAAAGGPAAAAAFAAAGPLGRLGMLL
                     QGAYGLTGVRWYPEGIAKSSPAEPTPVHRNPHYQLRRAVPSGGVTYPAECYVVTAGTAG
                     TEGTEEEDGLDAGVYHYDAVRHALAVLSAGRPPAELTPPEGGVRIVVTQPLWKNYFKYG
                     DFSYRLGAMDTGAVVGQFALAARSWELRCRVTFGVDERRIADLLGLDPEHEAVPAVLDV
                     SLGDPVGPAASAAETAPPVGRPRWLGESVPPGPATGTRRMHAACLAAGRPGRPVDLPPV
                     VLPDLAGQADVELPRPAGRPVSVADTWSRSALGEQFRGTPLPAEVLADWLTTVLAPLDC
                     DVTGEQAGRADTDTGERAGRPGTGTVTGEAAPTHARCLLIARSVPGVPPGAYLPHPDGR
                     RLTRLAAGDFGPEVQRSMFADYMNVGQAPLTAVMIGAADPHRGPAGPIGYRTQHLLAGV
                     LAQRLAACAARDGRSAHPVLGFVSGVLDDAFGLRARGLTSLLLVPVGGYRRGLYLENSL
                     SPLATRAGDGSGI"
     CDS             16071..17909
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Thiopeptide_F_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Heterocycloanthracin_C_RRE"
                     /gene_kind="biosynthetic"
                     /note="hypothetical protein"
                     /product="TsrG"
                     /protein_id="ACN52297.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 1.9e-29,
                     bitscore: 92.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     2e-10, bitscore: 30.9, seeds: 5, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPTDTTTGTSEAAGTSEAAGTSDATGTSDATGTSDATGTVLRL
                     RADAYYVPVPNGVWIRTTDGSFTLNGKAVATWVERLAPLLDEGVVPARLLGALRPEQAG
                     FVEQLLTLLEKRGVVRREAAADGFGPDLARLFPQQAAFLGHFASRPAEAFDRVRRHRVA
                     VAGPAGRADVLVTTLMEAGFGDFALLDAEPSTELRDLAADFERRGAPVRLSGPDGDPHD
                     RTLIGVFDPGTDGEADARRFLDRAGALGGGAWAGLVSGQAMLLKGQVPGSGRACVRCAW
                     RRLAHKAVALPHSDTLGHVPVSMAATVLAQELFQYVAGADDSVLGEGVVVDLTRLSVWR
                     TDVDPDPDCPACSAARPSGVPAPAHRRTSAYPDAVFGARCFGPLFSCTPEELPQFPLTA
                     LRVRVNPPGRTAPTGALDGPVVVARSMVDARAEAALTAVEATLPAADEAAVAGVGRDHA
                     EALARALLRWADRTPEDARAEGGREPVRTEGTGTAPALAELAALADTDVAVGVTHLPSG
                     LWRARADDGTGAVVRTGFDPDQAAERALTALLARRQLGPRPDGAPVVAAWPGPVPSRER
                     VGEVASALGLTWREAVLPPLVAADLTAIVLTGESTG"
     CDS             17906..19951
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_kind="biosynthetic"
                     /note="putative cyclodehydratase"
                     /product="TsrH"
                     /protein_id="ACN52298.1"
                     /sec_met_domain="TIGR03604 (E-value: 3.4e-80, bitscore:
                     260.0, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 2.9e-63, bitscore: 204.9,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPPTTAPHAPEGVDDTAAELRRLLDDVARVVDTPAAITAAAPL
                     HAGLPAEGDGRPVVLVNLGWDADLSGLPAAGTTVLPVYGLRGRVVVGPVTRPGLPGCPH
                     CLGLRVRATDRPEGVPRGEPAVPRRLSARPDAWLPPGTARLVAAVVRAELARLAAGEPP
                     LGTEAAYTVGPARLAGDWHPALPHTLCDTPHCRGARRPLPPPLPDLATPLPATGVGSAR
                     RFPAARFAERLEREYLDGWSGVTRSAAVGDRAVLPSTQVRVPTVWGFDEIAIGRAEDYA
                     GARPAAILEGLERYAGWHCGGRDPVRFASYAELASADAAEPSGGPGGPDRPAASDAVVD
                     PRSLLLHPEEAYGQPGFEYTPYAPEIPTGWAEAYSALTGRRTLVPFHVAYYGATRRPET
                     GPRFVYENSNGCALGSGTEEALLAALLEVSERDAFLCAWLSGTPLPEIDLGRLTGEAAR
                     AVRTVRHRTGRELRAFRALGAFDVPVALLVSTAEDPDLPATLVTAGSGLTVERALLGAV
                     HEMAASAPVNTVEFQRRRAELEAALDDPGLVRRMEDHALVGALPEARPWFSFLLDGTPP
                     GVPGPAAPDGLTPSGDVAADLAAMLAAARRDGQDVVVVDHTTSELDRLGLRCVKAIVPG
                     TVPMTFGHRHRRLPPPATLRAFRARHTDGPVEFSPEEVRHEPHPFP"
     CDS             19929..21353
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 150; E-value: 1.6e-45)"
                     /gene_kind="biosynthetic-additional"
                     /note="cytochrome P450"
                     /product="TsrI"
                     /protein_id="ACN52299.1"
                     /transl_table=11
                     /translation="MSHTRSPETTTPAPATPVTADDGLTALPHGMGWVVGSRALAVRLL
                     GDQRLGVLEPRPVMEHLATKVDPGLRPLIDEISSFAERVMLQTGHDRHQELRRAFGGFF
                     DADAVEARAPRLRQAAEEIVRPFAAAGGGEFMTAVAFPYAVRTGARLIGFTDAEYRLLH
                     KLSQQVALVAYAARVEDPAEAVRAGHAALVRVREILADARAVAPRDSVLGAWHAGEIGL
                     PDADVEANAVMLVQASLETVAGMLGNTAVRVLDTPGALADPVLLEERIDAALRAEPPLK
                     TLERVVREPFRLAGREFRAGQVVSVRVADANRLDDAPVAGRALFSFGWGAYRCLGARLA
                     RHQARELFQALHRAAPDATYADAGAAVERVRHIRFDMPRRLPVRCAPPVAEAAPPPSGV
                     LPDAHTEVPTEVPTDVLTDVLTEALEEDDVDRPLTSLEREVTYVVLTENGVTVPEDLRG
                     PTTIREWVTWAASARG"
     CDS             21329..22642
                     /NRPS_PKS="Domain: AMP-binding (111-352). E-value: 4.8e-21.
                     Score: 66.6. Matches aSDomain:
                     nrpspksdomains_ACN52300.1_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     108.9; E-value: 3.7e-33)"
                     /gene_kind="biosynthetic-additional"
                     /note="acyl-CoA ligase family protein"
                     /product="TsrJ"
                     /protein_id="ACN52300.1"
                     /sec_met_domain="AMP-binding (E-value: 2.4e-27, bitscore:
                     85.9, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGGLGAWLKQAEPVLRRSRAGVVTERGRHPWPSLLARAERLAAGL
                     PDAPYGWVVPADGGERSIVGLLALGLLGPAPRWVLGDPAAWAADGHKPLGDGELTAAGP
                     QAAPPPEVAGPTYATASSGTTGQPKLLFGRPHAIPSAVRLYADGMPEYAAAEVFATCSA
                     IDFAAAFYMVAAPAMTLGRDLVLFRPGSWATAVPELAGRPGVCLAPPALAALGARTAAG
                     RHDFRGTSFVPAGGGLTPERAGRIRAGFPGCDFLTMLGSTETGLVTVGRTVRADGHVGA
                     PLPGKPVWLEDVGPDGVGTLWTRGPDTRFAVTGGRLTTGPDGAVTTGDLAHRADGGGGF
                     VLDGRADDLVKVDGVSVYPREITAAVRALPGVRDASVSVDRSRTGDRLTVIVMGTDAVT
                     EDRVRDACARLPVPVTPHRVLCRPADETAYDARGKVLR"
     aSDomain        21662..22384
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACN52300.1_AMP-binding.1"
                     /evalue="4.80E-21"
                     /label="ACN52300.1_AMP-binding.1"
                     /locus_tag="ACN52300.1"
                     /protein_end="352"
                     /protein_start="111"
                     /score="66.6"
                     /tool="antismash"
                     /translation="VAGPTYATASSGTTGQPKLLFGRPHAIPSAVRLYADGMPEYAAAE
                     VFATCSAIDFAAAFYMVAAPAMTLGRDLVLFRPGSWATAVPELAGRPGVCLAPPALAAL
                     GARTAAGRHDFRGTSFVPAGGGLTPERAGRIRAGFPGCDFLTMLGSTETGLVTVGRTVR
                     ADGHVGAPLPGKPVWLEDVGPDGVGTLWTRGPDTRFAVTGGRLTTGPDGAVTTGDLAHR
                     ADGGGGFVLDGRADDLVKV"
     CDS_motif       22358..22414
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACN52300.1_0001"
                     /evalue="1.00E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="ACN52300.1"
                     /protein_end="362"
                     /protein_start="343"
                     /score="15.0"
                     /tool="antismash"
                     /translation="GRADDLVKVDGVSVYPREI"
     CDS             22752..23942
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 250.9; E-value: 3.5e-76)"
                     /gene_kind="biosynthetic-additional"
                     /note="cytochrome P450"
                     /product="TsrK"
                     /protein_id="ACN52301.1"
                     /sec_met_domain="p450 (E-value: 2.5e-08, bitscore: 23.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTGPSRAAVTEALLKCPAPLYERMRRQGPLVWSRPDRTWVVTG
                     YELARLVLRDPRFSLPGPPPGSQWSADGSHAGFFQSMLLACEGERHARLRRFLGRLFTP
                     RAIRARTVRIEAAMAALLDEAEQRSSLDGVAELAARLPVSVIGDLVGIPDADRDEVSEL
                     CRVISRGGGVASGKPAEDDVDRALTHVDALGRLVDRWTRTPELLVPDSVLALADEARDT
                     PDALTRTEVLANVFSLYIAGHDTSRNMLSGLLLRLATHPGLLAGLADGTVDAQAEVDLL
                     LLGESPLTFTVRVAREECELASRRIQPGDRIRVMLGAANHELLTSGDAKDGNTGVSFGE
                     GRHVCLGAHLARTEGRVMLDAVSRRWSGLRLADDPAWTPHFLHRGLDRLPLEIAWR"
     CDS             24005..26743
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     28.9; E-value: 3.9e-09)"
                     /gene_kind="biosynthetic"
                     /note="putative lantibiotic dehydratase"
                     /product="TsrL"
                     /protein_id="ACN52302.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.2e-10, bitscore:
                     30.4, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVRRRCRVPGSVLADLGSDRVWGAAAAWAYAEDAVQRTGTRLADQ
                     VGESVPTVRQEERRDLLRVRRAAFNSRPLPADSGAVLGGPAAALAEEYTRALTARDTNR
                     HELDLALADLARTSGATVDALLRDPHLARSVELSVPGLLAAGPVGALDPAAAKKTRRRA
                     LTLLRLMQRAASKPTPFAGFATTHVLFENTAPAASDLPSRSHVRIDRAVIEWVRQWIAA
                     GGHRSLRPERLWLTANPTAAVRQDASGTRVTWLLSRADGTERVLSAPCGAALAGTLARL
                     REPVRLDTVAPGGTLPDGLARLVARGLLEIGPRLPSHGRRTLHAAADATAPAPDLDLDL
                     DPDATEARQARQLHDALGVLRDAEDALAADPAHAGARRDAKDGIAAVATALGIGVRAGG
                     GDRSAVGEDVVGVMGVRADDDVPRADGTGPFGPEVLADLGRVQRVVPLLGFELPFQLAT
                     ALAFRRRFGTDPVPVLTAYAWFLDEGRRESDALLADCQAEELATVLALRHRLFDGLRAA
                     ADRNPGAPEAACDPGLLDAVAADLPDAVMDLSCAAWPVQLAGDRVVVNGVGTGYGRFAA
                     RVAAGLDPARLAVLRDWAATAATPHEHGVPVDIAASLGATVNERPLLLPAALGYPGRAL
                     ECAPETPGARVDLSSCAVRVAGGRLLLFGGEGDDAPGTGPGPGAGAGAGTGTGTGRFAG
                     RPLFPVPHNATLPTVAPGLYRWLSRLGPGSGATLALWDHVDALAAPRDPEAVRHYPRLT
                     LGRLVLSRRTWKVPAAALPAEALPGAAGAGGTAREALAWYRWCARTGVPRRSFLRGTTL
                     PDPWDVVRGLADRRPVDAARSTSGGAALRKPLYVDFSQPLCWPALAPAPGDTLTFTEPL
                     PDPAGGTTAAAPGSRVTEYVLETSQPPRARATEGCAAATRP"
     CDS             26760..28559
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: PF04055"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 156.3; E-value: 1.8e-47)"
                     /gene_kind="biosynthetic"
                     /note="putative radical-SAM domain containing protein"
                     /product="TsrM"
                     /protein_id="ACN52303.1"
                     /sec_met_domain="PF04055 (E-value: 1.1e-15, bitscore: 48.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRKGTVALINPNQIHPPIAPYALDVLTTALEASGFEAHVLDLTF
                     HLDDWRQTLRDYFRAERPLLVGVTCRNTDTVYALEQRPFVDGYKAVIDEVRRLTAAPVV
                     AGGVGFSTMPFALVDYFGIEYGVKGPGEKIICDLARALAEGRSADRIHIPGLLVNRGPG
                     NVTRVAPPALDPRAAPAPSSSPSPSPAPSSSSAPVPVPLSFAAVGHHESRAWQAETELP
                     YTRRSGEPYKVDNLRYYREGGLGSILTKNGCVYKCSFCVEPDAKGTQFARRGITAVVDE
                     MEALTAQGIHDLHTTDSEFNLSIAHSKNLLREIVRRRDHDATSPLRDLRLWVYCQPSPF
                     DEEFAELLAAAGCAGVNIGADHTRPEMLDGWKVTAKGTRYYDFADTERLVQLCHRNGML
                     TMVEALFGMPGETLETMRDCVDRMMELDATVTGFSLGLRLLPYMGLAKSLAEQCDGVRT
                     VRGLQSNNASGPIVLKQLHQCDGPIEYERQFMFDESGDFRLVCYFSPDLPEAPGTADSP
                     DGIWRASVDFLWDRIPKSEQYRVMLPTLSGSSENDNNYADNPFLTSLNRKGYTGAFWAH
                     WRDREAIMSGATLPLGELAEAVR"
     CDS             28556..29374
                     /NRPS_PKS="Domain: PKS_KR (11-188). E-value: 4.2e-11.
                     Score: 34.9. Matches aSDomain:
                     nrpspksdomains_ACN52304.1_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     168.2; E-value: 3.9e-51)"
                     /gene_kind="biosynthetic-additional"
                     /note="short chain dehydrogenase"
                     /product="TsrN"
                     /protein_id="ACN52304.1"
                     /transl_table=11
                     /translation="MTAPALPLAGQVALVTGAGRGIGRMVAVALAEAGMTVGLVGRNRR
                     LLDVTARACAAAREAASGDGSGDGSGGGPEAGVAVAVADVRAPAEIREAAEAVRAALGP
                     VDLLVNNAGLVDQGELPFWEADPERWWEVFETNVRGTVNTCRAVLPEMTRRGSGRVVNV
                     NSRLAVQGDPRYSAYCGSKATLLALDAVAAEPLRDRGVHLFDISPGMVRTDMTLSMAVC
                     AGRDDWTDPALFLAAILRVAHGDLDPLAGRFLHVGADDFDALLSERRLAV"
     aSDomain        28589..29119
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ACN52304.1_PKS_KR.1"
                     /evalue="4.20E-11"
                     /label="ACN52304.1_PKS_KR.1"
                     /locus_tag="ACN52304.1"
                     /protein_end="188"
                     /protein_start="11"
                     /score="34.9"
                     /tool="antismash"
                     /translation="VALVTGAGRGIGRMVAVALAEAGMTVGLVGRNRRLLDVTARACAA
                     AREAASGDGSGDGSGGGPEAGVAVAVADVRAPAEIREAAEAVRAALGPVDLLVNNAGLV
                     DQGELPFWEADPERWWEVFETNVRGTVNTCRAVLPEMTRRGSGRVVNVNSRLAVQGDPR
                     YSAYCGSKATLLAL"
     CDS_motif       28595..28681
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ACN52304.1_0001"
                     /evalue="8.40E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ACN52304.1"
                     /protein_end="42"
                     /protein_start="13"
                     /score="12.0"
                     /tool="antismash"
                     /translation="LVTGAGRGIGRMVAVALAEAGMTVGLVGR"
ORIGIN
        1 tctgcgtgtg cccgctcagt ctcccggcgc ctcccccggc tccgtcggcc cctccactga
       61 tgccgccggc cccaccggct cctcgcgctc cttggccaga cgggcggtca gccggaggac
      121 ggcgtcgttg gccgccgggt cgccgacggt gacgcggacg ccctcgcccg cgacggcgcg
      181 gacgaggatg ccctcgcggg ccgccgccgc gacgaaggcg gccgagcggg agcccagcgg
      241 cagccagcag aagttggcgg ccgacggcgc cacctcccag ccctgcccgc gcagttccgc
      301 ggtgagccgg tcccgttcgg cgacgacgcg gtccacgcgc gcgtacacct cggaccgccg
      361 ggcgagaacg gtccgcgcgg ccgcctcggc gacggtgccg acggcgaagg gcagcagccg
      421 ggtgcgcagg acgtccgcca cctcgcggcg ggcgagcgcg aagccgacgc gcaggccggc
      481 cagcccgtac gccttcgaga aggaccggag gaccaccacg ttcggcaggc cgcggtagac
      541 gtccggcccg tcgagggtgt ccttgtcccc ggcgaactcc cggtacgcct cgtccaggac
      601 gacgaccacg tgctccggga ccgcgcggag gaaggcgagc agggcgtcgg cgccgagcgc
      661 ggtgcccgtg gggttgtggg ggttgcacac gacgagcgcg cgggtgtcgg gggtgacggc
      721 cgccagcatg cgcggcagat cgtgccggtg gtcccgcagc gggatctcga cggcggtggc
      781 cccggcggcg gccacggcca gcgggtacgc gtcgaacgac ggccgggcgt agacgacctc
      841 gccccgccgc ggggccgccc actggatgac gtgctggagg atcacggcgg agccggggcc
      901 cgtgaccacg tcgtgctcgg gtacggagtg ggtggccgcg atcgccgccg tcagctcccg
      961 ggcgaacggg tcggggtagc ggtgcgcccc gcgcagcgcg tcccggagcg cctcgtccag
     1021 gccggtcacg gggacggccg gcatctcgtt cagcgaaagc cggtgctccg ggccggacgc
     1081 tcccggttcg gtgactcccg tcatgtcgtc gcacctcctc gcgggtcagg gacgcgtggg
     1141 aacggtgagg gcgtcgtcga ggaacgccgt gaggtccgcg gtcgcgcggt cgcgcccctc
     1201 gtcgtggaac aggccgtgca gcgctcccgg atagacgcgt tcggccaggt ggaagccgcg
     1261 gatcttctcc acgccggccc gggtctcgtc gatcagggcc agcggatcgg cgtcgccgtg
     1321 cagccagagc gtcggcagga aggccaggct ctcgcccccg ttgatccgtt cgaggcaggt
     1381 gacgacggac tccagggtgt cccggacgaa cgcgccgtgc cagatcagcg ggtccgcgtt
     1441 gtagcgggcc gcctcggcgg ggtcgcggga catcaccgag ccgacgtcca ccggcatctc
     1501 ggggatctcc gcgaaggcga ggagcgaggt cgccgtgtgc caggagccga gcacgggcgc
     1561 ggcgagcacg agcgcggcga ggtcctcggg gtggcgctgg gcgtaccgga cggccaccat
     1621 cccgccgacc gagtgcccga tcatcaccac ggggagcccc gggtggtccg cgcgggcccg
     1681 ctcgacgacc gtggcgaggt cggcgacctg ctcgtcgtgg tccgtcacga gcgcgcgtgc
     1741 gccgcccgag cggccgctgc cggcgtggtc cggcgcgtac acggcggcgc cgtgccgggt
     1801 cagcgcgtcg gccagccggc cgtagcggcc cgcgtggtcg gcgtacccgt gcacgaacac
     1861 cgcgagatag cggggcgccg tctccggcgg ccagacgtgc agatggatcg ggtgccggac
     1921 gccggcgaac cgccgtgccg tcgtctcctc ggtcatcgtt ccctcttccc ttcgtcgccg
     1981 gtccaccgag ccgcgcgcgc cgtcgcgccc ggcgtcactc cgccagctcc acccggtagt
     2041 cccgcatcca gtcgttgatc ttcagcaggg actcgaatcc cacccgcagg aaccgcagtt
     2101 cctccgggga cgccttccgc accgcggcgt acgcctcggc cgcgctcttc tcgtccatca
     2161 gcgcgcggac cggtgccccg gtgtcgtcca tgagtgcgcc gagccggccc ttgagcagct
     2221 ggtcgtaggc gggatcggcg atcgtcgggt acggctcctt cttccgggtc agtacggagt
     2281 ccgggagctc gggggccatg gccgcgcgca gcaggctctt ctcccggccg tcgaaggtct
     2341 tcatcgacca cggcacgttg aagacgtact ccaccagggc gtggtcgagg aacggcaccc
     2401 gcacctccag gcccacggcc atgctcatcc ggtccttgcg ttccaggagc atcggcagga
     2461 agcgggtgag gaagaggtgg ccgaccttcc gcatccgccg gtcctcctcg gcctccccgg
     2521 gcaggacggg gacggcggcg accgcctcgg cgtaccggtc ggcccggtac gcgtccaggg
     2581 agagccgctc gggcagggcc gggtcgagga acgccgggcc gccggcggcg gccacgcccg
     2641 ccatgtacat ccaggggaag gtctccgcgc ggacggcgtt ctcgtcgtgg aaccaggggt
     2701 agccgccgaa gagttcgtcg gcgccctcgc cggacagcgc gaccgtggaa cgctgccgga
     2761 tcgccttgaa cagcaggtag agggacgtgt ccatgtcggc gaggccctgg ggcaggtcgc
     2821 gggcccggag cacggccgcc cgcgccgccg ggtcggacag cagcttcgcg tcgagggtca
     2881 ggtcctcgtg gcgggcgccg atgtggcggg ccagttcggc ggcgtacgcg ctgtcgtcgc
     2941 caccgcgcgg gccggtgacg aagcccggac cggagccggc ggcggagaag ccgaccgaga
     3001 aacaggtgag cgggtcctcg ccgcggtccc gcagcgcccc gacggcgagc gccgccacgg
     3061 agctggagtc cagaccgccc gagagcagcg agcagagcgg cacgtccgcg acggtctggc
     3121 cggcgacgga cgaccccagc aggtcacgga cccggccgat cgtggtgtcg agatcgtcct
     3181 cgtgcgggcg cgcggggagt tcccagtacg cgcgctccgt gatcccgccg cgcgcgacgc
     3241 ggacgacgtg cccggggcgc acttggcgca tcccgtcgaa gatcgcgtgc ccgggggtgt
     3301 tcacccaggt catcagctcg cgcagaccgt ccgaggtcag ccgggcgcgg gcctcggggt
     3361 gggccaggat cgccttcggc tcggagccga agaggacacc gtccggggtc gggtagtagt
     3421 agagcggctt gacgcccaac cggtcccgga tcagcaggag ttcctggccg cgggcgtccc
     3481 agagcgcgaa cgcgaacatg ccggtgaggt gccgggtgac gtcctcgccc cactccaggc
     3541 aggcgcgcag gacgacctcg gtgtcgctcc gggtgcggaa ggtgtggccg gcggagacga
     3601 gccgggcgcg cagctcgtcg aagccgtaga tctccccgct gtaggagagg gcggccgtga
     3661 cctgcccgtt ctcctcggcg agcatgggct gcgcgccgcc ggcgatgtcg atgacggcga
     3721 gccgccggtg gcccagggcc accgggccgc cgtaccaggt gcccccggcg tcggggccgc
     3781 gacaggccat cgtccgtgtc atcgcctcca ccgcggaacg ctcggcgccc aggtcccgcc
     3841 cgaaggccac ccagcccgct atgccgcaca tccgtcctcc tccatttcct gccgctttcc
     3901 tgccgctttc ctgccgcttt cctgccgctg ccctgccgtt gccctgccgt tgccctgccg
     3961 ttgccctgcc gttccgacga ctcgcgaggt acgtgggcgc gcccgccggg tcagtccggc
     4021 agcgcgccga gctgccggtg cagcccgagc aggtccatct cgtcccagtg ctgggcgaac
     4081 agaccgtcct cgatgaggaa gatgtcgatg aggccgaccg agaagcgccg tccggaggcc
     4141 gggatgccga ggatcgggcc gacctgccgg ccgctgaagg tcatccgcgc gacggccttg
     4201 tccccctcca cgacgaggtc gtcgagggtg aggctgaggt cctccaccgt cgaggcccag
     4261 cggcggatcg cggcccgcat gccctcgatg ccgcgctcga cggccgggtt ggggtgccgg
     4321 tactcggggt gcagacagtg gtccaggtgg cgcgggtctc cttcgttgta cgccgccagg
     4381 aaatgctcca tgagctgctg tacggatgct cggtccacgg ggatcgcctt ccggtccggt
     4441 gggtgtgcgg ggcaggacgg gttacggggg ggggcggggg aggccggggg tgtcaggagg
     4501 cggcagggcg tacggccgtg tcgctggcct tggccccggc ctccacctcg gcctcggcct
     4561 cgggcgccgg ctcggcgagc cggtccagcc ggggcggatg cacgggagcc gtctcctcgc
     4621 cgagcgtcgt cgccgcgatg aggtcgcacg cgtcggcgtt gctgtacggg tgcatcgtcc
     4681 cggcccgtac gtcgcggtgg gcccgctcgt acaccgagcc gggccgcagg gccggggtgc
     4741 cgatgatccg gatcacccgg tcgacgatct ccacggcgtt gttggtgccc acgttcttgg
     4801 tcaacacggc acgggccatg ccctgttgga tggtgagcgc gttccacaag ccgttgccca
     4861 tcacctcgcc ggcggtccgc tcgatcaggg cgcgcgaggt ctcgatcagc tcctcgcagg
     4921 cggcgatctc cgcgcggatg tacggccggt cctcccagcc gcggctccgg acgtcccgta
     4981 cgcaggtctc gaacgcgccg acggccacgc cgagatagac cgcggcgaag gtgggcatcg
     5041 cccagcccca cacggtctgg agcagcgaac cgtccagact cccgacgggg taggaggtga
     5101 ggacgttctc ctccggcacc atgacgtcgc ggagttcgat gttctcgctg cgggtggccc
     5161 gcagtcccga ggtgttccag gtgccttcga ggacccggac gccgggactg tcggcgggga
     5221 tacggaagac caggacgtgc gggccgtcgg ggtgttcgcg gtactcggcc atcgaggtca
     5281 tgtgggtcat gacggccgag ccggtgccga aggtcttgtc gccggtgacc aggtaaccgc
     5341 cttccacctt gcgggccttg gcgccggtgg tgcgcacgag cgcgtgtccc ggctcggccg
     5401 tggcgcccat gaggatcacg cggccctcga cgatctccgt cagcgtcttc cgggcgcgct
     5461 cgtcgcccgt ggtgcgccag gcgcgggcca tctggccggc catggagagg tgcatgttga
     5521 cggcgagggc ggtggaggcg cagccggcgg ccagccgttc ctgggccacg gccatgtcgg
     5581 cgagggtgcc gcccagcccg ccgagttcgc gcggcacggt cagcgccaga tagccggcgg
     5641 cgcggagttc gtcgatgttg cggaacggga acgcggccgt ccggtcgtgc tcggcggccc
     5701 gctcgcggaa gaccgcggcc atgtcctccg ccagctcgac gtaccgctgc cgggccggcc
     5761 gggtgatcag gaggtgcatc aggactccag ctgtcggagg aggggtgtca cgaggagaag
     5821 ggccttcgcc gggcgccggt cacaccggtc gctccggagg cgccggtcac acggacgccg
     5881 gtcacaacga ggcgcaaacg gaggcgggtt cggaggccgc acgtcaggcg acggtgggtg
     5941 aagcggaggc ggattcggag acggaatcgg agacggaatc ggggacggaa tcggggacgg
     6001 aatcggggac ggaatcgatg acggccgggc cggtgaccag ctcggcggcg acgagccacg
     6061 tgcgggcggc cccgggcgtc ccgcgcggcg gggtccgcgg caccatccgc ccggccgcct
     6121 cgtccaggtc gcagggttcg cgcacctcgg cccgccagcc gcggccggcg agccacgcct
     6181 cgggctcggc caccccggaa cgccaggggc gccccgcgtc ccgcatctgc cgcagccagt
     6241 cccgcatcca aggggcccgg tacagatcgg tgttgacctg ctccaggcag agcacgctgc
     6301 cggcggcgga gagctcggtg acccggtcga cgaccgcgtc cacctgcgcc tcggtcaggt
     6361 aatagaggac tccttcgacc agccatacgg tcggcagacc ggggcggaag cccgcctcgg
     6421 cgagcgcggc gggccagtcg ccggtcaggt cggcggcgac cgggacgcgc cgacagcggt
     6481 cggcgaccag gccggagcgg gacaggaagg cgctcttctc ctccactccc tcgggcaggt
     6541 ccacctcgta gagggtgacg cccgggggcc aggggagccg gaaggcccgg ccgtccatgc
     6601 cggcggcgag cacgacgacc tgccgggccg ggccgccggt cacggcgcgg atcagacggt
     6661 cgtcgaagaa cgcggtccgc acggcgagta cgtcgaagcg ggaactcggt tcggtgcgga
     6721 ggcggtcgta gaggtccggg tcggtgcgcc ggacgaactc caccgcgagc gggtcctcga
     6781 acagccggcc gtcgggacgg agcgactcgg ctgcccgggc gcaggcgatc cagtgggcgg
     6841 tctcgatcaa actcgacatg ggctcttctc gcagagagcc gggcgccggc gcgcccgggt
     6901 gagggtcacc acggatccgc ggccgcgcgt cagcggcctt cggtcgcctc gccgacggcg
     6961 ggcgcggcag acgcgggagg tgcggcgggt gcggcaggcg cggcaggcgc ggtgggcgta
     7021 cccgtcgccg ccggctcgtc gtcgatcccg agcgcgcggg acatcccgcg gcggagcgac
     7081 cagtgcagga tgtccgtctg gttgtgccgg aactgggccc agtaggcgtc gcccgccttg
     7141 ttcctggtcc gcaggacgac accgatgtac gccttgccgt cggcgacgat gaaggacatc
     7201 cggtgttcga gcagcttgtc catgtcgccg aggagcactt ctcgctcgct cgcctcgaag
     7261 acctcgtacg gaccgaggcg ctccccgacc cggggcagcg gctgttcccg cttgctgcgc
     7321 atcgtgttgg gcttgacgcc gaaggggcgc atgacgacgc cctggacccg gatccacagg
     7381 tcgaccagcc agaacgcccg gtcgggcgtg aggctgggac ggtccatggt cagccgggcg
     7441 agctccctgg cgtcgatcct ccgatggtcc gggatcgcca cctccgccgc ctccgcgtgg
     7501 gtgtgctctc cactgtcacg gaaacgcgcg agagccgagt cgttcggaat tgaacagctg
     7561 gctatatgca tttcgagatt ccccatgggt tggcttcgcc acgctcaggg cctcgggacg
     7621 tcataggtgt ccagaattcg acggccgaag tggcgcatca ctgcaccgag cctatgcaga
     7681 gatcgattct cgactcagcc ggagagtaaa catttccgta tgtgatctac gtcacagcca
     7741 tttatccgga ggtgcccttg agcgcttcaa cttgacttgc ctatggtcga gatcagccgg
     7801 gcgacggagt ccggaagccg gctacagcag tttcccgtgg ccggcccacg tgcggcgcga
     7861 tcgacgcgac cgcagacttg ccgaaaggtt gtgaacggca tgagcaatgc cgccctggag
     7921 atcggtgtcg agggactcac gggtctggac gtcgacaccc tggagatcag cgactacatg
     7981 gacgagacgc tgctcgacgg tgaggacctg accgtcacga tgatcgcgtc cgcctcctgc
     8041 accacctgca tctgcacctg cagctgcagc tcctgaggta acacccggcg cggaggactg
     8101 ttcctccccg cccgccggac ctgaccgttg cagtcgacca ggtccgcgat ctaaccggga
     8161 gtgggacccg gacctgcccg ttgcagtcga gcaggtccgg ggcccgaccc ggagtacccc
     8221 ggacctgccc gttgcagtcg agcaggtccg gggcccgacc cggagtcatc tccggccgtg
     8281 ctcgctcgga ggctgtcggc ggacccgccg ccggcctccg gacgagcacc ctcactatgc
     8341 ccgatgacgg cgtggacaac tagttccggc ggtacgtctt cggcatgtcc tattgcaccg
     8401 cggacggctt tcgcacgtcc gttcaaacgg cctcccatgg ccgcggaaac ggccccatac
     8461 ggccgagaga acggagtgtc ggtcccgcat gcccggacgg gcttcccgtc gggtgcgccg
     8521 ggccccgaat gacgctccgc cgggtattga gcggccctta ttctgtttac ggcaacagaa
     8581 agctgatatc acgtgcgacc cgtaattctg gtgcacggtc tcctgggcac ggaagacgcg
     8641 cattacgcgg ggtgccggaa atggtggacc cgccctgtca cggaaatacg tcttccaggc
     8701 cacggaaccg gcggcgaaat cccaccccat cccgccgccg cggcgataga ccgcgtccgc
     8761 gaggccatcc gcgaacagcc ggaacctccc gtggtcgtgg ggctttccta tctgggtgcc
     8821 gccgtggcct tccgggccgc ggccggtttt cccgccaccg tggccggaat cgtcatgtcg
     8881 ggctactcgt tcctggtgtc gccggacacc ctgaaccgct ggctggcggg cttcaccaga
     8941 atggcctccc atcagcccgc ggcccagcgc catttcgccg aactgcacgg ccccacctgg
     9001 gagaatctgc tcaccgcgac cttcgccgag ctgtccgacg gctgcctgcg gctgcccggc
     9061 gtcgcggacc tggagcacct cccggtaccc gtccagctcg tcaacggctc actgctccag
     9121 aacgagcgga acgcgatcgg tccggcggcc gccgccggtg ccgacgtcgc ggtgatcgcc
     9181 ggggccggcc atgtcgtacc gatggacgcg ccgcgcgtct tcgccgccac cgtcgaggac
     9241 ttcgccgacc gggtcacggc cgggcgcacc gctttccacg agcggcggcg cgcggccgaa
     9301 agggccgcgg ccgaaccggc ggtaccgccc gaggccggca ccggaaccga gcccgtcgcc
     9361 cggaaagcgg ccacccatgg atagtccgga gatcacgtac gccggatacg gcgtcgtccg
     9421 cgtctgttcc caacccgccg acatcatcgc ccagttgtcc tcgcgcgagg ccgcccgcgt
     9481 ctgcgacgag ctcagggacg tacggcgtac ctggcaggac ctcgcccccc gggtcgccga
     9541 ggaactcacc gaggtggtcc ccctcctcac cgaccgggac gagcggcgga ccgttctcgc
     9601 gctgcgccgc cggctgcacc gcgccgcgga cgtcccggcc gccgacctcg acgtcctgaa
     9661 cctcgcgtac ggaacctcgg cggacgggcc cggggcggcc gggaccgcgg tggccgggcc
     9721 cctggcgccc ggggccgccg cgctgcgggc cctcgccgag cgccgcgacg acctcgcggc
     9781 ccgcctggag ggcgcgtacg aggaagggct gaacgcggaa cggaaggtgc tcgcctccgc
     9841 cgccctcgac cccgccctgc gtgccggagc ccagctgagc gcggacggtc tgctgcgcaa
     9901 catggaccgc tacgccgccg ccgtcgccga gggcaccgcc cccggcaagc gggagcggat
     9961 gaccgagtcc accgtcctcc atctgctgac ccgcagcacc ctcaagcctt cccccttcgg
    10021 gcagttggtg cacacccggc cggtcctcct gccgaagcgc gcgacggacg ccacgcccgt
    10081 catcgctccc gtcaccgctc ccggcacgga cgaggcggcc gagcggccgg tttccgtctg
    10141 ccggctcccc cgccagctcg tgagctgggt ggagcgttcc ctcgccggcc ggcccgcctt
    10201 ccggcatgtc gccgtcctgc gccgcgcacc ggtcgtcggc tcctcgaagg agggtgtcgt
    10261 cttcctgctg cggggccggg acggcaccca cgagccggcc gccaaggaac ggttcgtccg
    10321 cgtcccgccc ggcgtggtgg tcacggcggt cctggccctc gcggcggacg ccgccgtacc
    10381 cgagcgggag ctgcgggaac ggtgcgccgc cctgcccggc acggaccctg ccgccgccgg
    10441 tgccgccctc gacgcgctga tcggccaggg cgtcctcgcc cgcgacctgg gcgtcggcga
    10501 ccagcacccg caccccctcg cccgcctggc cgccctcctc cccccggact gcgacgccgg
    10561 cctgcgcgcg gccgtcagcg ggctggccgg cgccgagtcc gcgttcgaga ccgccggcct
    10621 cgaacggcgc gaggaactcg tctcccgtat caaggagcac gtggcccggg tcgccgaact
    10681 caccggcgtc gccaccccgc cgatcgacgt cgcccgcacc ctcgtctacg aggacgcggt
    10741 cgtggccgtc ccgcgcgccg aggcgcccgg ccggtggggg cggcatctgc ccgcgctggc
    10801 cccgtggcac cggctgctgc cgctcttcga cgacgccgcg cacgtccggg cgatcgtcgc
    10861 cgacgtggtc aggacccact tcgggcccgg gccgcaccgg ctccttcccc tgttcgcggc
    10921 gctgtcctcg gccaaggtgc aggccgtcct caccgagcgg ctcaccgacg tgtcggcgcc
    10981 gctgccgacc cggttgcgca cccttcagga cgcggtgttc gcgctcgccg atcccgacgg
    11041 cggcgcggac acggtgacgg tcgacccgga gcgggccgcg cggctcgccg acgacctgcc
    11101 gtcctggatc ccgcgctggt cccgcgcgag ctggcacgtc cagcaccacg ccgcccccga
    11161 cggcggtctg ctcgtcgtga acggcggatc gatcggcttc ggccgcgcga tctcccgctt
    11221 cctgcccgcc tacgccgccg ccggggacgc cggtttcggc gacctggtca cggccgagat
    11281 cgcccgggac gacgacccgt ccgcgcccct cacggacctc gcggccgtgc tcggcatcaa
    11341 cgccaacgtg cactccccgc tgctcggccg gcacctccgc tacccctgcg cgaccccgga
    11401 ggagtggggc gggaacaccg gcgtctccct ggaggactgc tgggtcgtgt acgacgcgga
    11461 cacgggccgg ctgctgccgc gcctgggcaa ggacggtccc gtcctgcggc tggtcatgct
    11521 gaacttcctg ctcaacgaac tcgccccgcg tttctaccag ttcctcaact tcttcagctc
    11581 gggcagcctc gccaacctcg cctggtggga ccgggtcgac cagcgccgcg aagccggtgc
    11641 cggtgccgac ggtggtgccg gtgccgacgg tggtgccggt gccggtggtg gtgccggctc
    11701 gggtacggac tccgtacgcc actacccgcg ggtccgctcc ggcagcctcg tcctggcccg
    11761 ccgcacctgg aaggtccccg acgcccggct ccccggcctc gccggcgcga ccggtgtcgc
    11821 ggccttcgcg gaggtacggc gctggcagga gtcgctgggc ctccccgacc aggtcttcta
    11881 ccgcggcttc accctccccg acccgctcgt cccgatgtcc cgggaggagc agcggacctg
    11941 ggcgaggacc ctcgcccggt tccccacctc cgccgaacgc aagcccacct tcctggactt
    12001 caccagcgtc accagcgtga ccgcctggca gcgggcgctg cgccggtgcc agggcggcct
    12061 gaccttccag gagtgcctgc ccgccgtggg cgaggacgaa ggggcggcgg gcggcctccg
    12121 ggagcggttc accgaggaat tcatcgtcga gaccaccgag accgaggagg aagggtgagc
    12181 accgccccgg cacacccctg gctgtcctgt catgtcttcc accacggcga caccgatccg
    12241 ctgatcgcgg agtgcctgct ccccctggtc gacgacctgc gccgggcggg acgcgtggaa
    12301 cgccacttct atctgcggca ctgggaacgc ggcccgcacg tccggctccg gatgcgggtg
    12361 ccggcggagc accacgacgc ggtacgcgcg gagaccgagc ggcgcgtcct cgactacctc
    12421 gggcggcgcc ccggccccgt cgacaccgat ccggcacggc tgcgggacgc gctgcgccgg
    12481 ctcagcgaac tggagcacgg cgacgcctcc gatgtcgccg tgcgcacccc ggagccgccc
    12541 aactcccttc gctggatcga ctatcagccc gagctggcca agtacggcgg gcccgaaggc
    12601 gtggcgatcg cggaggacgt cttccacgcc ggctcggtgc tgaccggcca ggtcctccgg
    12661 ctggtcgaca acgaccgcgc ccggatgggc atcgcgctcc agctgctgct gctcgcctcg
    12721 cgcgcgctgg gcttcggtcc cgacgaacgc gccgtcttcc tccgtaccta ccaggaacgc
    12781 tggtccggat acgtcacgga cccccgcgtc ctcgcctcct gggaccggca gtaccagctg
    12841 cagcgggagc agtacgcggc cctgctcgac ggcctcgacg ccggcgaccc cgtcgggaag
    12901 gggctcggcg cgtactggga acggaccctc gtccaggccc tggagcggct gcgcccgctc
    12961 gtcgggacgg gccgggtgtg gccggcggag accgaccccg cggcaccgcc ggtggtcgcg
    13021 ctcgcggccc tcgtcagcca gttcctgcac accaccaaca accggatgaa cgtccgcccg
    13081 caaggcgagt gcttcgtcgc ctacctggcc tcgcgcgcgg ccgaggacca gcgcgccgcc
    13141 cggtccggca ccgccccgac ggccgacccc gcccagacgg cacacgagag ggatgagcgt
    13201 catgtccacc agtgaacaga aggatctcac cgtcagcgtc ccgtggtcgg tgcaggagga
    13261 cctccttctc gacgtggccg cgcccctgct cgacgagtcg gtggaactcg gggagacgga
    13321 ctcgtggttc tacctccgcg agaaccacgg cgggcggccg ttcctgcggc tgcgcttcgc
    13381 gagccgcagc ccgtcggtcg aacgccgcct gaaatcacgg atcctggcgc acgtcgggcc
    13441 gacgatcgac gccggcgacg tcttcacgta ccagccgtac aaccacgaac acgactggct
    13501 gggcggcacc gccgggctcg ggctcgccga gaacttctgg accgagacca ccccgctggc
    13561 gctggacacc ctgcgcgcca cccgcggcaa ccgggccctg cggctcgccg tggccttcga
    13621 cttcctcgtg tgcaccggcg tcatgctcgc gccccatctg ccgccgtcca tcgccaagtt
    13681 cggctacaag gccggctatc tctcctacct ggccacgttc gagggctaca tgctgctgat
    13741 ccgggacccc gagggcaccc gggccaagca cgcccaacgg tacgagaaga accgggagtt
    13801 gctgcggcca cgccttcgca cgctcgtcga gcagatgagc gagccggacg gcgagctgac
    13861 cgacgtgccc gagctggccc gcgagtggct ggtccggctg cgcgactacg tccccgccct
    13921 ccagaagggc ttcgacgagg gccgcttcta cctctacgcc acgccgcgca aggccgagac
    13981 ggccaagctc acgccgtcgc ccgacggcct ctaccgcagg cccgacgtgg agtggctgtc
    14041 cgacctgccg gagcccccgg tggccggcat ccaccgggcg atcgccgaca acacgtacta
    14101 ccagggcatg atccgcgagg accgccgctt cctggcctcg cggctggcgc aggcgtacac
    14161 caactggcat ctgtaccggc tgggcttcct gctcgccgac cggtacacgc tcttctacct
    14221 gatcgcccgc gccttcgagg aggagtacga cctcgacgcg gcggcgctga tccggtcggt
    14281 acggccggaa gcagaggtcg ccggatgacg gccccgggga ccgccgaggc caccgctccg
    14341 gtcgaggccg ccgcccccgc cgaggccgcc ggaaccgggc ccttcgacgc cgccggagtg
    14401 gacggcttcg tccgccggct ccggggcgac ttcgacgaag tccacccgga ccagtggcag
    14461 atcgactggc gcagcatccc cagccccttc cgctggtacg tcgacctgcc ccggcgcgat
    14521 ctgcccgcgc tgtcgcgcgc ggccgcggcc ggcgggcccg ccgcggcggc cgcgttcgcc
    14581 gcggccgggc cgctcggccg gctcggcatg ctgctccagg gcgcctacgg actgaccggc
    14641 gtgcggtggt accccgaggg catcgccaag agcagccccg ccgagcccac ccccgtccac
    14701 cgcaacccgc actaccagct gcgccgcgca gtgccctcgg gaggcgtgac gtaccccgcc
    14761 gagtgctacg tcgtcacggc gggcacggcg ggcacggagg gcacggagga agaggacggt
    14821 ctcgacgccg gggtgtacca ctacgacgcg gtacgccacg cactggccgt gctgtccgcc
    14881 ggccggccgc ctgcggagct gacgccgccg gagggcggtg tccggatcgt cgtcacccag
    14941 ccgctgtgga agaactactt caagtacggc gacttctcct accggctcgg cgccatggac
    15001 accggtgccg tcgtcggcca gttcgcgctc gccgcccggt cctgggaact gcgctgccgg
    15061 gtgacgttcg gggtggacga gcggcggatc gcggacctgc tcgggctcga tccggaacac
    15121 gaggccgtcc cggccgtgct ggacgtctcc ctgggagacc cggtgggacc ggcggcatcc
    15181 gcggccgaga ccgcgccccc ggtcgggcgg ccccgctggc tgggcgagtc cgtcccgccc
    15241 ggccccgcca ccggcacccg ccggatgcac gccgcgtgcc tggccgccgg ccgccccggc
    15301 cggcccgtcg acctcccgcc ggtcgtcctg cccgacctgg ccgggcaggc ggacgtggag
    15361 ctgccccggc cggccgggcg gccggtgtcg gtcgcggaca cctggtcccg gtcggcgctc
    15421 ggcgagcagt tccggggcac gccgctgccc gccgaggtcc tggcggactg gctgaccacg
    15481 gtgctggccc cgctggactg cgacgtcacc ggagagcaag ccggccgcgc cgacaccgac
    15541 accggagagc gggccggccg ccccggcacc gggaccgtca ccggcgaggc cgccccgacg
    15601 cacgcccgct gcctgctgat cgcgcggtcc gtgcccggcg tgcctccggg cgcctatctg
    15661 ccacacccgg acgggcgccg gctcacccgg ctcgccgccg gggacttcgg gcccgaggtc
    15721 cagcgcagca tgttcgccga ctacatgaac gtcgggcagg cgccgctgac cgccgtcatg
    15781 atcggcgccg ccgatccgca tcgcggtccg gccggcccga tcggctaccg cacccagcat
    15841 ctcctcgcgg gcgtcctcgc ccagcgtctc gccgcgtgcg cggcgcgcga cggcagatcg
    15901 gcgcacccgg tgctcggctt cgtcagcggc gtcctcgacg acgcgttcgg gctgcgggcc
    15961 cggggcctga cgtccctgct cctcgtcccc gtgggcggtt accgccgggg cctctatctc
    16021 gagaacagtc tgagtccgct cgccacgcgg gcgggcgacg ggagtggaat atgacagcgc
    16081 cgaccgacac gacgaccggg acgagcgagg cggccgggac cagcgaggcg gccggaacga
    16141 gcgacgcgac cgggacgagc gacgcgaccg ggacgagcga cgcgaccggc accgttctgc
    16201 ggctgcgcgc cgacgcctac tacgtacccg tgccgaacgg ggtgtggatc cggacgacgg
    16261 acggctcgtt caccctcaac ggcaaggcgg tcgcgacctg ggtcgagcgg ctcgcgcccc
    16321 tcctggacga gggggtggta cccgcccggc tcctcggggc gctccggccc gagcaggccg
    16381 ggttcgtgga acagctcctg accctgctgg agaagcgggg agtggtacgc cgggaggccg
    16441 ccgccgacgg attcggcccg gacctggccc ggctcttccc ccaacaggcc gcgttcctcg
    16501 gccacttcgc ctcgcggccc gccgaggcgt tcgaccgcgt acggcggcac cgggtggcgg
    16561 tcgcgggacc cgcaggacgc gcggacgtcc tcgtcacgac gctcatggag gccgggttcg
    16621 gcgacttcgc cctcctggac gccgagccga gcaccgaact ccgggacctg gccgccgact
    16681 tcgagcggcg cggcgcaccc gtacgcctgt ccgggccgga cggtgatccc cacgaccgca
    16741 cgctcatcgg ggtgttcgac cccgggacgg acggcgaggc cgacgcccgg cggttcctcg
    16801 accgggccgg cgcgctcggc ggcggcgcct gggcgggcct ggtcagcggc caggcgatgc
    16861 tcctcaaggg acaggtgccg ggctccggcc gggcctgcgt acggtgtgcc tggcggcggc
    16921 tggcccacaa ggccgtcgcg ctgccgcact ccgacacgct gggccatgta ccggtgtcga
    16981 tggcggcgac cgtgctcgcc caggagctgt tccagtacgt cgccggggcc gacgactccg
    17041 tactcggcga gggcgtcgtg gtggacctga cccggctcag cgtctggcgt acggacgtcg
    17101 acccggaccc ggactgcccg gcctgctccg cggcccgccc gtccggcgta ccggcgccgg
    17161 cgcaccgccg gacgtccgcg taccccgacg ccgtcttcgg cgcccgctgc ttcggcccgc
    17221 tgttctcgtg cacccccgag gaactgcccc agttcccgct caccgcgctg cgggtgcggg
    17281 tcaacccgcc ggggcgcacc gcgccgacgg gggcgctcga cggcccggtc gtcgtggcgc
    17341 ggtccatggt cgacgcgcgc gccgaggcgg ccctgaccgc cgtcgaggcg acgctccccg
    17401 cggcggacga ggcagccgtc gcgggcgtgg gccgggacca cgccgaggcg ctggcgcgcg
    17461 ccctgctccg gtgggccgac cggacgccgg aggacgcccg cgcggaaggc ggcagggaac
    17521 ccgtccgcac cgaggggacg ggcacggcgc ccgccctcgc ggagctggcc gccctcgccg
    17581 acacggacgt cgccgtcggc gtcacgcacc tgccgagcgg cttgtggcgg gcccgggccg
    17641 acgacggcac gggtgccgtc gtccggaccg ggttcgaccc cgaccaggcg gcggagcgcg
    17701 cgctgaccgc cctgctggcc cgccggcagc tgggaccgcg gcccgatgga gcaccggtcg
    17761 tggcggcgtg gccgggcccg gtcccgtccc gggagcgggt cggcgaggtc gcgtccgcgc
    17821 tcggcctgac ctggcgcgag gccgtcctgc cgccgctggt cgccgccgat ctgaccgcga
    17881 tcgtcctgac cggggagtcc accggatgag cgcgccgccg acgacggcac cccacgcgcc
    17941 cgagggcgtc gacgacacgg cggccgagct gcgccgtctg ctcgacgacg tcgcccgggt
    18001 cgtcgacacc ccggccgcga tcaccgccgc cgcccctctc cacgccggcc tccccgccga
    18061 gggggacggc cgcccggtcg tcctggtgaa cctcggctgg gacgccgacc tgtccggcct
    18121 gcccgccgcg ggcaccaccg tgctgcccgt gtacgggctc cgcggccgcg tcgtcgtcgg
    18181 cccggtgacc cgacccggac tgcccggctg cccccactgt ctggggctgc gcgtgcgcgc
    18241 cacggaccgc cccgagggcg tcccccgggg cgagccggcc gtcccccgcc ggctgtccgc
    18301 gcggcccgac gcgtggctgc cgccggggac cgcgcgcctg gtggcggccg tcgtccgcgc
    18361 cgaactggcc cggctcgccg ccggtgagcc gccgctcggc accgaggccg cctacacggt
    18421 cgggcccgcc cggctggccg gcgactggca tccggcgctg ccgcacaccc tgtgcgacac
    18481 gccgcactgc cggggcgccc gccgcccgct gccgcccccg ctccccgacc tggccacgcc
    18541 gctgcccgcg accggtgtgg gctcggcccg ccgcttcccg gccgcccggt tcgccgaacg
    18601 gctggagcgg gagtacctcg acggctggtc gggcgtcacc cgctccgccg ccgtcggcga
    18661 ccgggccgtc ctgccgtcga cgcaggtgcg ggtgcccacg gtctgggggt tcgacgagat
    18721 cgcgatcggc cgcgccgagg actacgcggg cgcgcgcccg gcggcgatcc tggaggggct
    18781 ggaacggtac gccggctggc actgcggcgg ccgcgacccc gtccgcttcg cctcctacgc
    18841 cgaactcgcc tccgccgacg ccgctgagcc ctccggcgga cccggcgggc cggaccgacc
    18901 cgccgcctcc gacgccgtcg tcgatccccg ctccctgctc ctgcaccccg aagaggcgta
    18961 tggacaaccg gggttcgagt acacgccgta cgccccggag atcccgaccg gatgggcgga
    19021 ggcgtactcc gcgctcacgg gccggcggac cctcgtgccg ttccacgtcg cgtactacgg
    19081 cgcgacccgc cgccccgaga ccggcccgcg cttcgtctac gagaactcca acggctgcgc
    19141 cctcggctcc ggcaccgaag aggcgctcct ggccgccctg ttggaggtgt ccgagcgcga
    19201 cgccttcctg tgcgcgtggc tctccgggac gccgctgccg gagatcgacc tcggccggct
    19261 gaccggcgag gcggcgcggg cggtacgaac ggtgcgccac cgcaccggcc gcgagctgcg
    19321 ggccttccgg gcgctgggcg ccttcgacgt ccccgtggcc ctcctcgtgt cgacagcgga
    19381 ggatccggac ctgccggcga ccctggtcac cgccggctcg ggcctcacgg tggaacgggc
    19441 gctgctcggc gccgtccacg agatggccgc ctccgcaccc gtgaacacgg tcgaattcca
    19501 gcgccgccgg gccgagttgg aggcggcact ggacgatccc gggctggtcc gccggatgga
    19561 ggaccacgcg ctggtgggcg ccctgcccga ggcgcgcccg tggttctcct tcctcctcga
    19621 cggcaccccg ccgggcgtgc ccggcccggc cgccccggac ggcctcacgc cgtccggcga
    19681 cgtcgccgcc gatctcgccg cgatgctcgc ggccgcgcgg cgcgacgggc aggacgtcgt
    19741 cgtcgtggac cacaccacca gcgagctgga ccgcctgggc ctgcgctgtg tgaaggcgat
    19801 cgtgcccggc acggtgccga tgaccttcgg ccaccggcac cgccggctgc cgccgcccgc
    19861 gacgctccgc gcgttccggg cccggcacac cgacggcccc gtcgagttct cccccgagga
    19921 agtacggcat gagccacacc cgttcccctg agacgacgac tcccgctccc gcgacgcccg
    19981 tcaccgcgga cgacggcctg accgccctgc cccacggcat gggctgggtc gtcggcagcc
    20041 gcgccctggc ggtccggctg ctcggtgacc agcgcctcgg cgtgctggaa ccgcgcccgg
    20101 tcatggagca cctcgccacc aaggtcgatc cgggcctgcg cccgctgatc gacgagatct
    20161 cctcgttcgc cgaacgcgtc atgctccaga ccggccacga ccggcaccag gagctgcgca
    20221 gggcgttcgg cggattcttc gacgccgacg cggtcgaggc ccgcgctccg cggctgcggc
    20281 aggcggccga ggagatcgtg cggcccttcg ccgcggccgg gggcggcgag ttcatgacgg
    20341 cggtcgcctt cccgtacgcg gtgcgcaccg gcgcgcggct catcggcttc accgacgcgg
    20401 agtaccggct gctgcacaag ctgagccagc aggtcgcgct cgtcgcctac gccgcccggg
    20461 tcgaggaccc ggcggaggcg gtccgggcgg gccacgccgc gctggtccgg gtccgggaga
    20521 tcctcgcgga cgcccgggcg gtcgcgcccc gcgactcggt gctcggcgcc tggcacgccg
    20581 gggagatcgg cctgccggac gcggacgtcg aggccaacgc cgtcatgctg gtgcaggcgt
    20641 cgctggagac cgtcgccggc atgctcggga acaccgccgt acgggtcctg gacaccccgg
    20701 gggcgctcgc cgaccccgta ctcctggagg agcggatcga cgcggccctg cgcgcggagc
    20761 cgccgctcaa gacgctggag cgggtggtca gggagccgtt ccggctggcc gggcgggagt
    20821 tccgggccgg ccaggtcgtc tccgtccggg tcgcggacgc caaccggctg gacgacgcgc
    20881 cggtggccgg ccgcgcgctg ttctccttcg gctggggcgc gtaccgctgt ctcggcgcgc
    20941 ggctcgcccg ccaccaggcg cgggaactgt tccaggcgct gcaccgcgcc gcgccggacg
    21001 ccacgtacgc cgacgccggc gccgcggtcg agcgggtccg gcacatccgc ttcgacatgc
    21061 cgcgccgcct ccccgtgcgg tgcgccccgc ccgtcgccga ggccgccccg ccgccatccg
    21121 gtgtgctccc cgacgcgcac accgaggtac ccaccgaggt acccaccgac gtgctcaccg
    21181 acgtcctgac ggaagcactc gaagaggacg acgtggaccg gccgttgacc tcgctggagc
    21241 gcgaggtgac gtacgtcgtc ctgaccgaga acggggtgac cgtccccgag gacctgcgcg
    21301 gtcccacgac gatccgggag tgggtgacat gggcggcctc ggcgcgtggc tgaagcaggc
    21361 cgaaccggtg ctgcggcgtt cgcgcgccgg ggtggtgacc gagcgcggac gtcatccgtg
    21421 gccgtcgctc ctcgcccggg cggagcggct ggcggcgggg ctgcccgacg ccccgtacgg
    21481 ctgggtcgtc ccggcggacg gcggcgagcg gtcgatcgtg gggctgctcg cgctcgggct
    21541 gctcggcccc gccccccgct gggtgctcgg cgaccccgcg gcctgggccg cggacggcca
    21601 caagccgctg ggcgacgggg agttgacggc ggccgggccc caggcggcgc ctccgcccga
    21661 ggtcgccggc cccacgtacg ccaccgcctc ctcgggcacc accgggcagc cgaaactgct
    21721 cttcggccgg ccgcacgcga tcccctcggc ggtacggctg tacgccgacg gcatgccgga
    21781 gtacgcggcg gccgaggtgt tcgccacctg ctccgccatc gacttcgcgg cggccttcta
    21841 catggtggcc gccccggcga tgacgctcgg ccgcgacctc gtcctgttcc ggcccggctc
    21901 ctgggcgacg gccgtccccg agctggccgg ccgccccggc gtgtgcctgg cgccgcccgc
    21961 gctcgccgcg ctgggcgccc gtacggcggc cggacggcac gacttccgcg gcacctcctt
    22021 cgtccccgcc ggcggcggcc tcacccccga gcgggcgggc cggatccgcg cggggttccc
    22081 cggctgcgac ttcctgacca tgctcggctc caccgagacg ggactcgtca cggtcgggcg
    22141 tacggtgcgc gccgacggcc atgtcggcgc gcccctgcca ggcaaacccg tctggctgga
    22201 ggacgtcggg ccggacggcg tcggcaccct gtggaccagg gggcccgaca cccggttcgc
    22261 ggtgaccggg ggccggctca ccaccgggcc ggacggcgcc gtgaccaccg gcgatctcgc
    22321 ccaccgggcc gacggcggcg gggggttcgt gctggacggc cgcgcggacg acctggtcaa
    22381 ggtcgacggc gtcagcgtct acccgcgcga gatcacggcc gccgtccggg cgctgcccgg
    22441 tgtccgggac gcctcggtgt ccgtcgaccg ttcccggacc ggcgaccgcc tcaccgtgat
    22501 cgtcatgggg accgacgccg tgaccgagga ccgggtccgc gacgcctgcg cccgcctgcc
    22561 cgtcccggtc accccgcacc gggtcctgtg cagaccggcc gacgagaccg cctacgacgc
    22621 ccgcggcaag gtgctgcgct gagcgcgtcg agccgcccag gcgccgagac gccgagacgc
    22681 cgaggtcacc cagccgtcga agccgacgag ccgagcccgc cgagcccgtt gagaaagagc
    22741 gtgatgacga gatgacgacg accggaccct cccgcgcggc ggtcaccgag gcactgctca
    22801 agtgcccggc ccccctctac gagcggatgc gccgccaggg ccccctcgta tggagccgtc
    22861 ccgaccgcac ctgggtggtg accggctacg agctcgcccg gctggtgctg cgcgaccccc
    22921 gcttcagcct gcccggcccg ccgccgggat cgcagtggtc ggccgacggc agccacgccg
    22981 ggttcttcca gagcatgctg ctggcctgcg agggagagcg gcacgcgcgc ctgcgccggt
    23041 tcctcggacg gctgttcacc ccgcgggcga tccgcgcccg caccgtgcgg atcgaggccg
    23101 cgatggcggc gctcctggac gaggcggagc agcgctcctc cctggacggg gtcgcggagc
    23161 tcgccgcccg gctgcccgtg agcgtcatcg gcgacctcgt cggcatcccc gacgccgacc
    23221 gcgacgaggt cagcgaactg tgccgggtga tcagcagggg cggcggcgtg gcgtccggga
    23281 agcccgccga ggacgacgtc gaccgcgcgc tgacccacgt ggacgcgctg ggcaggctcg
    23341 tcgaccgctg gacgcggact ccggaactgc tcgtgcccga ctccgtgctg gcgctcgccg
    23401 acgaggcgcg cgacaccccg gacgcgctga cccgtaccga ggtcctcgcc aacgtcttca
    23461 gcctttacat cgccgggcac gatacctccc gcaacatgct cagcggccta ctgctgcgcc
    23521 tcgccaccca ccccggactc ctcgcgggcc tggccgacgg cacggtggac gcccaggcgg
    23581 aggtcgacct gctgctgctc ggcgagtccc cgctcacgtt caccgtccgc gtggcgcggg
    23641 aggagtgcga gctggcgtcg cggcgcatcc agcccggcga ccgcatccgg gtgatgctcg
    23701 gcgccgccaa ccacgagctg ctcaccagcg gcgacgccaa ggacggcaac accggcgtca
    23761 gtttcggcga gggccgccat gtgtgcctcg gcgcgcacct ggcgcgcacc gagggccggg
    23821 tgatgctcga cgccgtgagc cggcgatggt ccgggctgcg gctcgcggac gacccggcgt
    23881 ggacgccgca cttcctgcac cggggcctgg accgcctgcc gctggagatc gcatggcggt
    23941 gacgagcggg cccgtacacg agacggcccc cgtggctgcc gaccacgtcg tcccggggcc
    24001 ggtggtggta cgccgccggt gccgcgtccc gggctccgtc ctggcggacc tgggcagcga
    24061 ccgggtgtgg ggcgcggccg cggcctgggc gtacgcggag gacgccgtcc agcgcaccgg
    24121 cacccgactc gccgaccagg tcggggagtc ggtgccgacc gtacggcagg aggagcgccg
    24181 cgatctgctg cgggtacgcc gggccgcgtt caactcccgc ccgctgcccg ccgattccgg
    24241 cgccgtgctc gggggcccgg ccgccgccct cgcggaggag tacacgcgcg ccctgaccgc
    24301 gcgcgacacg aaccgtcacg aactagacct ggccctcgcg gacttggccc gtacgtccgg
    24361 cgcgaccgtc gacgccctgc tgcgcgaccc gcacctcgcc cggtccgtcg agctctccgt
    24421 acccggcctc ctggccgccg gccccgtcgg cgcactggac ccggccgccg cgaagaagac
    24481 ccggcgccgg gccctcaccc tgctccgcct catgcagcgc gccgcgtcga agccgacccc
    24541 gttcgccggc ttcgccacca cgcacgtgct cttcgagaac acggcaccgg ccgcttcgga
    24601 cctcccctcg cgcagccatg tgcggatcga ccgcgcggtg atcgagtggg tacggcagtg
    24661 gatcgccgcg ggcggccacc ggagcctgcg gccggagcgg ctgtggctca ccgccaaccc
    24721 caccgcggcc gtccgccagg acgcctccgg gacgcgcgtg acctggctcc tgagcagggc
    24781 ggacggcacc gaacgggtgc tgtccgcgcc atgcggcgcc gcgctcgccg gcaccctcgc
    24841 ccggctgcgg gaaccggtcc gcctggacac cgtcgcgccg ggcggcaccc tgcccgacgg
    24901 cctcgcgcgc ctcgtcgcgc gcgggctcct ggagatcggt ccacgtcttc cctcccatgg
    24961 ccggcggacg ctgcacgcgg cggccgacgc gacggcgccg gcaccggacc tggacctgga
    25021 cctggacccg gacgcgaccg aggcccggca ggcccgtcaa ctccacgacg cgctgggcgt
    25081 gttgcgtgac gccgaggacg ccctcgccgc cgatccggca cacgcgggcg cccggcgcga
    25141 cgcgaaggac ggcatcgccg ccgtcgccac cgcgctgggg atcggcgtcc gggcgggcgg
    25201 cggcgaccgt tcggcggtcg gcgaggacgt cgtgggcgtc atgggcgtcc gtgccgacga
    25261 cgacgttccg cgcgccgacg gcacgggccc cttcggcccc gaggtcctcg ccgacctcgg
    25321 ccgcgtccag cgcgtcgtgc cgctgctcgg cttcgagctg cccttccagc tggccacggc
    25381 cctcgcgttc cggcgccgct tcggcaccga tccggtgccc gtcctgaccg cctacgcgtg
    25441 gttcctcgac gagggccgcc gggaatccga cgcgttgctc gccgactgtc aggccgagga
    25501 actcgccacg gtcctcgccc tgcgccaccg gctcttcgac gggctccgcg cggcggcgga
    25561 ccggaacccg ggcgcgccgg aggccgcgtg cgatcccggc ctcctcgacg cggtggcggc
    25621 cgatctgccg gacgcggtca tggacctctc ctgcgcggcc tggccggtcc aactcgccgg
    25681 ggaccgcgtg gtggtgaacg gggtcggcac cggctacggc cgcttcgccg cccgcgtcgc
    25741 cgccggcctg gacccggccc ggctcgccgt gctgcgcgac tgggcggcga ccgccgccac
    25801 ccctcacgag cacggggtcc cggtcgacat cgccgcgtcg ctcggcgcca ccgtcaacga
    25861 gcggcccctg ctgctgcccg ccgcgctcgg ctatccgggc cgcgccctgg agtgcgcccc
    25921 cgagaccccc ggggcccggg tcgacctgtc ctcctgcgcg gtgcgcgtgg cgggcgggcg
    25981 gctgctgctc ttcggcggcg agggcgacga cgccccgggc accggccctg gccccggtgc
    26041 cggcgccggc gccggcaccg gcaccggcac cggccgcttc gcgggacgcc cgctgttccc
    26101 cgtaccgcac aacgcgaccc tgccgaccgt ggcccccggc ctgtaccggt ggctgagccg
    26161 cctcgggccg ggatccgggg cgacgctcgc cctgtgggat cacgtggacg ccctcgcggc
    26221 gccccgggac ccggaggccg tacggcacta tccgcggctg accctggggc ggctcgtgct
    26281 gagccggcgc acctggaagg tgcccgcggc ggcgctgccc gcggaagccc tcccgggcgc
    26341 ggcgggagcc ggcggaaccg cgcgggaggc cctggcctgg taccgctggt gcgcgcgtac
    26401 gggcgtgccc cgccgctcgt tcctgcgcgg cacgacgctc ccggacccct gggacgtcgt
    26461 ccgcggcctg gccgacagac gcccggtgga cgccgcccgc tccacctccg gcggcgcggc
    26521 cctccgcaag cccctctacg tcgacttctc ccagccgctg tgctggccgg ccctggcgcc
    26581 cgcgcccggg gacacgctga ccttcaccga accgctgccg gatcccgccg gcggcaccac
    26641 cgccgccgca cccggcagcc gcgtcaccga gtacgtcctg gagacctcgc agcctccgcg
    26701 cgcacgagcg accgagggct gcgccgccgc cacacggccg taagcaggaa gacgagatca
    26761 tgctccgtaa aggcaccgtc gctctgatca accccaacca gatccacccc ccgatcgcgc
    26821 cgtacgcgct ggacgtgctc accaccgcgc tggaggcctc cggcttcgag gcgcacgtcc
    26881 tggacctcac cttccacctg gacgactggc ggcagaccct ccgggactac ttccgggcgg
    26941 agcgcccgct gctcgtcggc gtgacctgcc gcaacaccga cacggtgtac gcgcttgagc
    27001 aacgcccctt cgtggacggg tacaaggcgg tcatcgacga ggtacggcgg ctcaccgccg
    27061 cgccggtcgt cgcgggcgga gtgggcttct ccaccatgcc cttcgccctg gtcgactact
    27121 tcggcatcga gtacggggtg aaggggccgg gcgagaagat catctgcgat ctggcgcggg
    27181 cgctcgcgga gggacggtcc gccgaccgca tccacatccc tggactgctg gtcaaccgcg
    27241 gccccgggaa cgtcaccaga gtggccccgc ccgcgctgga tccccgcgcg gcccccgcgc
    27301 cttcttcctc gccctcaccc tcgcccgcgc cctcttcctc gtccgccccg gtccccgtcc
    27361 cgctgtcgtt cgcggccgtc ggccaccacg agagccgggc ctggcaggcg gagaccgaac
    27421 tcccctacac ccggcggtcg ggcgagccgt acaaggtcga caacctgcgc tactaccgcg
    27481 agggcggcct gggcagcatc ctgaccaaga acggctgcgt ctacaaatgc agcttctgcg
    27541 tcgaaccgga cgccaaggga acgcagttcg cgcggcgcgg catcacggcg gtggtggacg
    27601 agatggaggc gctgaccgcc cagggcatcc atgatctgca caccacggac agcgagttca
    27661 acctctcgat cgcgcacagc aagaacctgc tgcgggagat cgtgcggcgc cgcgaccacg
    27721 acgcgaccag cccgctgcgc gacctccggc tctgggtcta ctgtcaacct tccccgttcg
    27781 acgaggagtt cgcggagctg ctggccgccg ccggctgcgc gggcgtgaac atcggcgccg
    27841 accacacccg tcccgagatg ctcgacgggt ggaaggtgac cgcgaagggc acccggtact
    27901 acgacttcgc cgacaccgag cggctggtgc agctgtgcca ccgcaacggc atgctgacga
    27961 tggtcgaggc gctcttcggc atgccggggg agaccctgga gaccatgcgc gactgcgtcg
    28021 accggatgat ggaactcgac gccacggtca ccgggttcag cctcggcctc cggctcctcc
    28081 cctacatggg cctggccaag tccctggccg agcagtgcga cggggtacgc acggtccgcg
    28141 ggctccagtc caacaacgcg tcggggccga tcgtcctgaa gcagctgcac cagtgcgacg
    28201 gacccatcga gtacgaacgg cagttcatgt tcgacgagtc cggcgacttc cggctcgtct
    28261 gttacttctc ccccgacctc cccgaggctc cggggacggc ggacagcccc gacgggatct
    28321 ggcgggcctc ggtcgacttc ctctgggacc gcatcccgaa gtccgagcag taccgggtga
    28381 tgctgccgac cctctccggc agcagcgaga acgacaacaa ctacgccgac aaccccttcc
    28441 tcaccagcct gaacaggaag ggatacacgg gcgctttctg ggcccattgg cgcgaccgcg
    28501 aggcgatcat gagcggcgcc acgctcccgc tcggggagct cgcggaggcc gtccggtgac
    28561 cgcccccgcg ctcccgctcg ccgggcaggt cgcgctggtc accggggccg gccgcggcat
    28621 cgggcggatg gtcgcggtcg ccctcgccga ggcgggcatg accgtcggac tggtcggccg
    28681 gaaccggcgg ctcctcgacg tcaccgcgcg cgcctgcgcc gccgcccgcg aagccgcctc
    28741 cggggacggc tccggggacg gctccggagg cggtccggaa gccggtgtcg ccgtggcggt
    28801 ggcggatgtc cgcgcgcccg ccgagatccg ggaggccgcc gaggcggtac gggccgcact
    28861 cggccccgtc gacctcctgg tgaacaacgc cggcctggtg gaccagggcg aactcccctt
    28921 ctgggaagcc gatccggagc ggtggtggga ggtcttcgag acgaacgtcc gcggcaccgt
    28981 caacacctgc cgggccgtcc tgccggagat gacccgccgc ggatcgggcc gcgtcgtcaa
    29041 cgtcaactcc cgcctcgccg tccagggaga cccccgctac tccgcctact gcggctccaa
    29101 ggcgacgctg ctcgccctgg acgcggtcgc ggcggaaccg ctccgggacc gcggggtcca
    29161 cctgttcgac atcagtccgg gcatggtgcg caccgacatg accctgtcga tggccgtctg
    29221 cgcgggccgc gacgactgga cggaccccgc cctgttcctc gcggcgatac tccgcgtggc
    29281 ccacggcgac ctcgaccccc tcgccggccg cttcctccac gtgggcgccg acgacttcga
    29341 cgcgttactg agcgaacggc ggctcgccgt ctgacggca
//
