LOCUS       BGC0000630              6227 bp    DNA     linear   BCT 22-MAR-2006
DEFINITION  Paracoccus haeundaensis astaxanthin biosynthesis gene cluster,
            complete sequence.
ACCESSION   BGC0000630
VERSION     BGC0000630
KEYWORDS    .
SOURCE      Paracoccus haeundaensis
  ORGANISM  Paracoccus haeundaensis
            Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
            Paracoccaceae; Paracoccus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 13:57:23
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6227
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..6227
                     /db_xref="taxon:225362"
                     /mol_type="genomic DNA"
                     /organism="Paracoccus haeundaensis"
     misc_feature    1..6227
                     /note="astaxanthin biosynthesis gene cluster"
     protocluster    1..6227
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[1599:5173]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1600..5173
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..6227
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..6227
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000630"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..6227
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            390..1118
                     /gene="crtW"
     CDS             390..1118
                     /codon_start=1
                     /gene="crtW"
                     /note="astaxanthin biosynthesis"
                     /product="beta-carotene ketolase"
                     /protein_id="AAY28417.1"
                     /transl_table=11
                     /translation="MSAHALPKADLTATSLIVSGGIIAAWLALHVHALWFLDAAAHPIL
                     AIANFLGLTWLSVGLFFIAHDAMHGSVVPGRPRGNAAMGQLVLWLYAGFSWRKMIVKHM
                     AHHRHTGTDDDPDFDHGGPVRWYARFIGTYFGWREGLLLPVIVTVYALILGDRWMYVVF
                     WPLPSILASIQLFVFGTWLPHRPGHDAFPDRHNARSSRISDPVSLLTCFHFGGYHHEHH
                     LHPTVPWWRLPSTRTKGDTA"
     gene            1115..1603
                     /gene="crtZ"
     CDS             1115..1603
                     /codon_start=1
                     /gene="crtZ"
                     /note="astaxanthin biosynthesis"
                     /product="beta-carotene hydroxylase"
                     /protein_id="AAY28418.1"
                     /transl_table=11
                     /translation="MTNFLIVVATVLVMELTAYSVHRWIMHGPLGWGWHKSHHEEHDHA
                     LEKNDLYGLVFAVIATVLFTVGWIWAPVLWWIALGMTVYGLIYFVLHDGLVHQRWPFRY
                     IPRKGYARRLYQAHRLHHAVEGRDHCVSFGFIYAPPVDKLKQDLKTSGVLRAEAQERT"
     gene            1600..2760
                     /gene="crtY"
     CDS             1600..2760
                     /codon_start=1
                     /gene="crtY"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /note="astaxanthin biosynthesis"
                     /product="lycopene cyclase"
                     /protein_id="AAY28419.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 2.4e-129,
                     bitscore: 420.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHDVLLAGAGLANGLIALALRAARPDLRVLLLDHAAGPSDGHTW
                     SCHDPDLSPHWLARLKPLRRANWPDQEVRFPRHARRLATGYGSLDGAALADAVARSGAE
                     IRWNSDIALLDEQGATLSCGTRIEAGAVLDGRGAQPSRHLTVGFQKFVGVEIETDCPHG
                     VPRPMIMDATVTQQDGYRFIYLLPFSPTRILIEDTRYSDGGNLDDDALAAASHDYARQQ
                     GWTGAEVRRERGILPIALAHDAAGFWADHAEGPVPVGLRAGFFHPVTGYSLPYAAQVAD
                     VVAGLSGPPGTDALRGAIRDYAIDRARRDRFLRLLNRMLFRGCAPDRRYTLLQRFYRMP
                     HGLIERFYAGRLSVADQLRIVTGKPPIPLGTAIRCLPERPLLKENA"
     gene            2757..4262
                     /gene="crtI"
     CDS             2757..4262
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 420.4; E-value: 2e-127)"
                     /gene_kind="biosynthetic-additional"
                     /note="astaxanthin biosynthesis"
                     /product="phytoene desaturase"
                     /protein_id="AAY28420.1"
                     /sec_met_domain="DAO (E-value: 1.4e-10, bitscore: 29.8,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAHSPAAKTAIVIGAGFGGLALAIRLQSAGIATTLVEARDKPGG
                     RAYVWHDQGHVFDAGPTVITDPDALKELWALTGQDMARDVTLMPVSPFYRLMWPGGKVF
                     DYVNEADQLERQIAQFNPDDLEGYRRFRDYAEEVYQEGYVKLGTVPFLKLGQMLKAAPA
                     LMKLEAYKSVHAKVATFIKDPYLRQAFSYHTLLVGGNPFSTSSIYALIHALERRGGVWF
                     AKGGTNQLVAGMVALFERLGGQMMLNAKVARIETEGARTTGVTLADGRSLRADMVASNG
                     DVMHNYRDLLGHTARGQSRAKSLDRKRWSMSLFVLHFGLREAPKDIAHHTILFGPRYRE
                     LVNEIFKGPKLAEDFSLYLHSPCTTDPDMAPPGMSTHYVLAPVPHLGRAEIDWAVEGPR
                     YADRILASLEERLIPNLRANLTTTRIFTPADFASELNAHHGSAFSVEPILTQSAWFRPH
                     NRDKTIRNFYLVGAGTHPGAGIPGVVGSAKATAQVMLSDLAGA"
     misc_feature    3570..3572
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4259..5173
                     /gene="crtB"
     CDS             4259..5173
                     /codon_start=1
                     /gene="crtB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /note="astaxanthin biosynthesis"
                     /product="phytoene synthase"
                     /protein_id="AAY28421.1"
                     /sec_met_domain="phytoene_synt (E-value: 2e-47, bitscore:
                     150.4, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDLVLTSTEAITQGSQSFATAAKLMPPGIRDDTVMLYAWCRHAD
                     DVIDGQALGSRPEAVNDPQARLDGLRVDTLAALQGDGPVTPPFAALRAVARRHDFPQAW
                     PMDLIEGFAMDVEARDYRTLDDVLEYSYHVAGIVGVMMARVMGVRDDPVLDRACDLGLA
                     FQLTNIARDVIDDARIGRCYLPGDWLDQAGARIDGPVPSPELYTVILRLLDEAEPYYAS
                     ARVGLADLPPRCAWSIAAALRIYRAIGLRIRKSGPQAYRQRISTSKAAKIGLLGVGGWD
                     VARSRLPGAGVSRQGLWTRPHHV"
     gene            complement(5170..6051)
                     /gene="crtE"
     CDS             complement(5170..6051)
                     /codon_start=1
                     /gene="crtE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 172.6; E-value:
                     1.6e-52)"
                     /gene_kind="biosynthetic-additional"
                     /note="astaxanthin biosynthesis"
                     /product="geranylgeranyl diphosphate synthase"
                     /protein_id="AAY28422.1"
                     /transl_table=11
                     /translation="MRRDVNPIHATLLQTRLEEIAQGFGAVSQPLGAAMSHGALSSGRR
                     FRGMLMLLAAEASGGVCDTIVDAACAVEMVHAASLIFDDLPCMDDAGLRRGRPATHVAH
                     GESRAVLGGIALITEAMALLAGARGASGTVRAQLVRILSRSLGPQGLCAGQDLDLHAAK
                     NGAGVEQEQDLKTGVLFIAGLEMLAVIKEFDAEEQTQMIDFGRQLGRVFQSYDDLLDVV
                     GDQAALGKDTGRDAAAPGPRRGLLAVSDLQNVSRHYEASRAQLDAMLRSKRLQAPEIAA
                     LLERVLPYAARA"
ORIGIN
        1 ggatccacga ctggggcatc cccacgaccg cgtcgctgcg cgccatcgcg ccgatgatgg
       61 ggccggaccg ggttctggtc gggtcgggcg gggtgcgtca cgggctggac gccgcgcggg
      121 ccatccgcct cggcgcggac ctcgtggggc aggcggcccg cgcgctgccc gccgcgcgcc
      181 acagcgccga ggccctgtcc gatcacctgt ccgacgtcgt gacccagctg cgcatcgcga
      241 tgttctgcac cggatcgggc gaccttgcag cgctgcgctg cgcgcctctg ctggtgccgg
      301 ggccgggtgg ccaatggtcg caagcaacgg ggatggaaac cggcgatgcg ggactgtagt
      361 ctgcgcggat cgccggtccg ggggacaaga tgagcgcaca tgccctgccc aaggcagatc
      421 tgaccgccac cagcctgatc gtctcgggcg gcatcatcgc cgcgtggctg gccctgcatg
      481 tgcatgcgct gtggtttctg gacgcggcgg cgcatcccat cctggcgatc gcgaatttcc
      541 tggggctgac ctggctgtcg gtcggtctgt tcttcatcgc gcatgacgcg atgcacgggt
      601 cggtcgtgcc ggggcgtccg cgcggcaatg cggcgatggg ccagctggtc ctgtggctgt
      661 atgccggatt ttcgtggcgc aagatgatcg tcaagcacat ggcccatcac cgccataccg
      721 gaaccgacga cgaccccgat ttcgaccatg gcggcccggt ccgctggtac gcgcgcttca
      781 tcggcaccta tttcggctgg cgcgaggggc tgctgctgcc cgtcatcgtg acggtctatg
      841 cgctgatcct gggggatcgc tggatgtacg tggtcttctg gccgctgccg tcgatcctgg
      901 cgtcgatcca gctgttcgtg ttcggcacct ggctgccgca ccgccccggc cacgacgcgt
      961 tcccggaccg ccataatgcg cggtcgtcgc ggatcagcga ccccgtgtcg ctgctgacct
     1021 gctttcactt tggtggttat catcacgaac accacctgca cccgacggtg ccttggtggc
     1081 gcctgcccag cacccgcacc aagggggaca ccgcatgacc aatttcctga tcgtcgtcgc
     1141 caccgtgctg gtgatggagt tgacggccta ttccgtccac cgttggatca tgcacggccc
     1201 cctgggctgg ggctggcaca agtcccacca cgaggaacac gaccacgcgc tggaaaagaa
     1261 cgacctgtac ggcctggtct ttgcggtgat cgccacggtg ctgttcacgg tgggctggat
     1321 ctgggcgccg gtcctgtggt ggatcgcttt gggcatgacc gtctatgggc tgatctattt
     1381 cgtcctgcat gacgggctgg ttcatcagcg ctggccgttc cgctatatcc cgcgcaaggg
     1441 ctatgcccgc cgcctgtatc aggcccaccg cctgcaccac gcggtcgagg gacgcgacca
     1501 ttgcgtcagc ttcggcttca tctatgcgcc gccggtcgac aagctgaagc aggacctgaa
     1561 gacgtcgggc gtgctgcggg ccgaggcgca ggagcgcacg tgacccatga cgtgctgctg
     1621 gcaggggcgg gccttgcgaa cgggctgatc gccctggcgc tgcgcgcggc gcggcccgac
     1681 ctgcgggtgc tgctgctgga tcatgcggcg ggaccgtcag acggccatac ctggtcctgc
     1741 cacgaccccg atctgtcgcc gcactggctg gcgcggctga agcccctgcg ccgcgccaac
     1801 tggcccgacc aggaggtgcg ctttccccgc catgcccggc ggctggccac cggttacggg
     1861 tcgctggacg gggcggcgct ggcggatgcg gtggcccggt cgggcgccga gatccgctgg
     1921 aacagcgaca tcgccctgct ggatgaacag ggggcgacgc tgtcctgcgg cacccggatc
     1981 gaggcgggcg cggtcctgga cgggcgcggc gcgcagccgt cgcggcatct gaccgtgggt
     2041 ttccagaaat tcgtgggcgt cgagatcgag accgactgcc cccacggcgt gccccgcccg
     2101 atgatcatgg acgcgaccgt cacccagcag gacgggtacc gattcatcta tctgctgccc
     2161 ttctctccga cgcgcatcct gatcgaggac actcgctatt ccgatggcgg caatctggac
     2221 gacgacgcgc tggcggcggc gtcccacgac tatgcccgcc agcagggctg gaccggggcc
     2281 gaggtccggc gcgaacgcgg catcctgccc attgcgctgg cccatgacgc ggcgggcttc
     2341 tgggccgatc acgcggaggg gcctgttccc gtgggactgc gcgcggggtt ctttcacccg
     2401 gtcaccggct attcgctgcc ctatgcggcg caggtggcgg acgtggtggc gggcctgtcc
     2461 gggccgcccg gcaccgacgc gctgcgcggc gccatccgcg attacgcgat cgaccgggca
     2521 cgccgtgacc gctttctgcg cctgctgaac cggatgctgt tccgcggctg cgcgcccgac
     2581 cggcgctata ccctgctgca gcggttctac cgcatgccgc atggactgat cgaacggttc
     2641 tatgccggcc ggctgagcgt ggcggatcag ctgcgcatcg tgaccggcaa gcctcccatt
     2701 ccccttggca cggccatccg ctgcctgccc gaacgtcccc tgctgaagga aaacgcatga
     2761 acgcccattc gcccgcggcc aagaccgcca tcgtgatcgg cgcaggcttt ggcgggctgg
     2821 ccctggccat ccgcctgcag tccgcgggca tcgccaccac cctggtcgag gcccgggaca
     2881 agcccggcgg gcgcgcctat gtctggcacg atcagggcca tgtcttcgac gcgggcccga
     2941 ccgtcatcac cgaccccgat gcgctcaagg agctgtgggc gctgaccggg caggacatgg
     3001 cgcgcgacgt gacgctgatg ccggtgtcgc ccttctatcg actgatgtgg ccgggcggga
     3061 aggtcttcga ttacgtgaac gaggccgatc agctggagcg ccagatcgcc cagttcaacc
     3121 cggacgacct ggaaggatac cgccgcttcc gtgattacgc ggaggaggtg tatcaggagg
     3181 gctacgtcaa gctgggcacc gtgcccttcc tcaagctggg ccagatgctc aaggccgcgc
     3241 ccgcgctgat gaagctggag gcctataagt ccgtccatgc caaggtcgcg accttcatca
     3301 aggaccccta tctgcggcag gcgttttcgt atcacacgct gctggtgggc gggaatccct
     3361 tctcgaccag ctcgatctat gcgctgatcc acgcgctgga gcggcgcggc ggggtctggt
     3421 tcgccaaggg cggcaccaac cagctggtcg cgggcatggt cgcgctgttc gaacggcttg
     3481 gcggccagat gatgctgaac gccaaggtcg cccggatcga gaccgagggc gcgcggacca
     3541 cgggcgtcac cctggcggac gggcggtctt taagggccga catggtcgcc agcaacggcg
     3601 acgtcatgca caactatcgc gacctgctgg gccacacggc ccgcgggcag agccgcgcga
     3661 aatcgctgga ccgcaagcgc tggtccatgt cgttgttcgt gctgcatttc ggtctgcgcg
     3721 aggcgcccaa ggacatcgcg catcacacca tcctgttcgg cccccgctac agggagctgg
     3781 tcaacgagat cttcaagggc ccgaagctgg ccgaggattt ctcgctgtac ctgcattcgc
     3841 cctgcacgac cgatccggac atggcgcctc cgggcatgtc cacgcattac gtgctggccc
     3901 ccgtgccgca tctgggccgc gccgagatcg attgggcggt cgaggggccg cgctatgccg
     3961 accgcatcct ggcgtccctg gaggagcggc tgatcccgaa cctgcgcgcc aacctgacca
     4021 cgacgcgcat cttcacgccc gccgatttcg ccagcgaact gaacgcccat cacggcagcg
     4081 ccttctcggt cgagccgatc ctgacgcaat ccgcgtggtt ccggccgcac aaccgcgaca
     4141 agacgatccg caacttctat ctggtcggcg cgggcaccca tccgggcgcg ggcattccgg
     4201 gcgtcgtggg ctcggccaag gccacggccc aggtgatgct gtccgacctg gcgggcgcat
     4261 gagcgatctg gtcctgacct cgaccgaggc gatcacccaa gggtcgcaaa gctttgccac
     4321 ggcggccaag ctgatgccgc cgggcatccg cgacgacacg gtgatgctct atgcctggtg
     4381 ccgccacgcg gatgacgtga tcgacggtca ggccctgggc agccgccccg aggcggtgaa
     4441 cgacccgcag gcgcggctgg acggcctgcg cgtcgacacg ctggcggccc tgcagggcga
     4501 cggtccggtg accccgccct ttgccgcgct gcgcgcggtg gcgcggcggc atgatttccc
     4561 gcaggcctgg cccatggacc tgatcgaagg cttcgcgatg gatgtcgagg cgcgcgacta
     4621 tcgcacgctg gatgacgtgc tggaatattc ctatcacgtc gcaggcatcg tcggcgtgat
     4681 gatggcccgc gtgatgggcg tgcgcgacga tcctgtcctg gaccgcgcct gcgacctggg
     4741 gctggcgttc cagctgacca acatcgcgcg cgacgtgatc gacgatgcgc gcatcgggcg
     4801 gtgctatctg ccgggggact ggctggacca ggcgggcgcg cggatcgacg ggccggtgcc
     4861 gtcgccggag ctgtacacag tgatcctccg gctgttggat gaggcggaac cctattacgc
     4921 gtcggcgcgg gtgggtctgg cggatctgcc accgcgctgc gcctggtcca tcgccgccgc
     4981 gctacggatc tatcgcgcca tcgggctgcg catccgcaag agcgggccgc aggcctatcg
     5041 ccagcggatc agcacgtcca aggctgccaa gatcggcctg ctgggcgtcg ggggctggga
     5101 tgtcgcgcga tcacgcctgc cgggggcggg cgtgtcgcgg cagggcctct ggacccggcc
     5161 gcatcacgtc taggcgcgcg cggcgtaggg cagaacccgt tccagcaggg ccgcgatttc
     5221 cggagcctga aggcgcttgc tgcgcagcat cgcgtccagt tgggcgcggc tggcctcgta
     5281 atgacgggac acgttctgca ggtctgacac ggccagaagg ccgcgccgcg ggccgggggc
     5341 cgcggcatcg cgaccggtat ccttgccaag cgccgcctgg tcgcccacga cgtccagcag
     5401 gtcgtcatag gactggaaca cgcggcccag ctgacggcca aagtcgatca tctgggtctg
     5461 ctcctcggcg tcgaactcct tgatcacggc cagcatctcc agcccggcga tgaacagcac
     5521 gccggtcttc aggtcctgtt cctgttcgac ccccgcgccg ttcttggccg cgtgcaggtc
     5581 caggtcctgg ccggcgcaca ggccctgcgg ccccagggac cgcgacagga tccgcaccag
     5641 ctgcgcccgc accgtgcccg acgcgccgcg cgcaccggcc agcagggcca ttgcctcggt
     5701 gatcagggcg atgccgccca gcacggcacg gctttcgcca tgcgccacat gggtcgcggg
     5761 ccggccgcgg cgcagcccgg catcgtccat gcagggcagg tcgtcgaaga tcagcgatgc
     5821 ggcatgcacc atctcgaccg cgcaggcggc gtcgacgatc gtgtcgcaga ccccgcccga
     5881 ggcctctgcc gcaagcagca tcagcatgcc gcggaaccgc ctgcccgacg acagcgcgcc
     5941 atggctcatg gccgcgccga gcggctgcga cacggcaccg aatccctggg cgatctcctc
     6001 aagtctggtc tgcagaaggg tggcgtggat cgggttgacg tctcgtctca tcagtgcctt
     6061 cgcgcttggg ttctgacctg gcgggaaggt caggccgggg cggcaccccg tgacccgtca
     6121 tccaccgtca acagtcccca tgttggaacg gttcacgccc gattgcgagc cttttcgacg
     6181 gcgacgcggg gtcgcgcggc aatttgtcca acaaggtcag tggatcc
//
