BGC0000631

BGC0000631: Botrydial biosynthetic gene cluster from Botrytis cinerea B05.10

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Location: 2,216,500 - 2,246,000 nt. (total: 29,501 nt).
This entry is originally from NCBI GenBank CP009816.1, but has been modified (see Modifications tab for details).

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KnownClusterBlast

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General information about the BGC

MIBiG accession	BGC0000631
Short description	Botrydial biosynthetic gene cluster from Botrytis cinerea B05.10
Status	Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: complete Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)	terpene (Sesquiterpene)
Loci	CP009816.1 2216500 - 2246000 via Knock-out studies
Compounds	Botrydial 8,9-epibotrydial 1-epibotrydial Dihydrobotrydial 10-Oxo-dihydrobotrydial 10-dehydroxy dihydrobotrydialone 10-epi-dihydrobotrydial Botryendial Botryenalol Botrydienal Norbotrydialone acetate 10-Oxodihydrobotry-1(9),4(5)-diendial 10-Oxodehydrodihydrobotrydial Dehydrobotrydienol 11-Hydroxydehydrobotrydienol 12-hydroxydehydrobotrydienol Secobotrytriendiol Secobotrytriene-10,12,15-triol Secobotrydiene-3,10,15-triol Secobotrydiene-3,4,10,15-tetraol 4β-Acetoxytetrahydrobotryslactone
Species	Botrytis cinerea B05.10 [taxonomy]
References	[1] Biologically active sesquiterpenoid metabolites from the fungus Botrytis cinerea. Collado, I et al., Phytochemistry (1996) DOI:10.1016/0031-9422(95)00643-5 [2] Studies on the biosynthesis of secobotryane skeleton. Durán-Patrón, R et al., Tetrahedron (2003) DOI:10.1016/s0040-4020(03)01025-1 [3] Structure-activity relationships of new phytotoxic metabolites with the botryane skeleton from Botrytis cinerea. Durán-Patrón, R et al., Tetrahedron (1999) DOI:10.1016/s0040-4020(99)00032-0 [4] Genetic and Molecular Basis of Botrydial Biosynthesis: Connecting Cytochrome P450-Encoding Genes to Biosynthetic Intermediates. Moraga, J et al., ACS Chemical Biology (2016) DOI:10.1021/acschembio.6b00581 [5] Sesquiterpene Synthase from the Botrydial Biosynthetic Gene Cluster of the Phytopathogen Botrytis cinerea. Pinedo, C et al., ACS Chemical Biology (2008) DOI:10.1021/cb800225v [6] Four New Lactones from Botrytis cinerea. Colmenares, A et al., Journal of Natural Products (2002) DOI:10.1021/np020107v [7] Secobotrytriendiol and Related Sesquiterpenoids: New Phytotoxic Metabolites from Botrytis cinerea. Durán-Patrón, R et al., Journal of Natural Products (1999) DOI:10.1021/np990252h [8] Functional Analysis of the Cytochrome P450 Monooxygenase Gene bcbot1 of Botrytis cinerea Indicates That Botrydial Is a Strain-Specific Virulence Factor. Siewers, V et al., Molecular Plant-Microbe Interactions® (2005) DOI:10.1094/mpmi-18-0602 [9] Functional analysis of the cytochrome P450 monooxygenase gene bcbot1 of Botrytis cinerea indicates that botrydial is a strain-specific virulence factor. Siewers V et al., Mol Plant Microbe Interact (2005) PMID:15986930 [10] Sesquiterpene synthase from the botrydial biosynthetic gene cluster of the phytopathogen Botrytis cinerea. Pinedo C et al., ACS Chem Biol (2008) PMID:19035644

Chemical products information

Botrydial Evidence: NMR [5], [8]

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C₁₇H₂₆O₅