LOCUS       BGC0000635             10074 bp    DNA     linear   BCT 16-JUN-2010
DEFINITION  Paracoccus sp. N81106 carotenoid biosynthesis gene cluster (idi,
            crtW, crtZ, crtY, crtI, crtB, crtE, crtX), complete cds.
ACCESSION   BGC0000635
VERSION     BGC0000635
KEYWORDS    .
SOURCE      Paracoccus sp. N81106
  ORGANISM  Paracoccus sp. N81106
            Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
            Paracoccaceae; Paracoccus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 13:57:54
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..10074
                     /db_xref="taxon:81397"
                     /mol_type="genomic DNA"
                     /note="Paracoccus sp. N81106 (old name: Agrobacterium
                     aurantiacum) is distributed as MBIC01143."
                     /organism="Paracoccus sp. N81106"
                     /strain="N81106"
     protocluster    1..10074
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[2953:6527]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2954..6527
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..10074
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..10074
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000635"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..10074
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            631..1713
                     /gene="idi"
     CDS             631..1713
                     /codon_start=1
                     /gene="idi"
                     /note="ipi"
                     /product="IPP isomerase"
                     /protein_id="BAE47464.1"
                     /transl_table=11
                     /translation="MTEISRRKSDHLRIVTEGRGAQDRLDSGFDQVRFLHQALPDLDMD
                     AVDTGTRFLGRSLGAPLLISAMTGGPEEAERINLHIAEACAHHRIALSVGSQRIAVEAG
                     GNGGLGASLRARAPQIPILGNIGAVQLNYGFGVAQAQRAVDMIQADALILHLNPLQEAI
                     QEGGDRNFAALLPRIEELATSLPVPLGVKEVGAGLSAPVARCLIDAGVTILDVAGAGGT
                     SWARVEAERGPDRLQALAAPFHDWGIPTTASLRAIAPMMGPDRILVGSGGVRHGLDAAR
                     AIRLGADLVGQAARALPAARHSAEALSDHLSDVVTQLRIAMFCTGSGDLAALRRAPLLV
                     PGPGGQWSQATGMETGDAGL"
     gene            1744..2472
                     /gene="crtW"
     CDS             1744..2472
                     /codon_start=1
                     /gene="crtW"
                     /note="4,4'-beta-oxygenase"
                     /product="beta-carotene ketolase"
                     /protein_id="BAE47465.1"
                     /transl_table=11
                     /translation="MSAHALPKADLTATSLIVSGGIIAAWLALHVHALWFLDAAAHPIL
                     AIANFLGLTWLSVGLFIIAHDAMHGSVVPGRPRANAAMGQLVLWLYAGFSWRKMIVKHM
                     AHHRHAGTDDDPDFDHGGPVRWYARFIGTYFGWREGLLLPVIVTVYALILGDRWMYVVF
                     WPLPSILASIQLFVFGTWLPHRPGHDAFPDRHNARSSRISDPVSLLTCFHFGGYHHEHH
                     LHPTVPWWRLPSTRTKGDTA"
     gene            2469..2957
                     /gene="crtZ"
     CDS             2469..2957
                     /codon_start=1
                     /gene="crtZ"
                     /note="3,3'-beta-hydroxylase"
                     /product="beta-carotene hydroxylase"
                     /protein_id="BAE47466.1"
                     /transl_table=11
                     /translation="MTNFLIVVATVLVMELTAYSVHRWIMHGPLGWGWHKSHHEEHDHA
                     LEKNDLYGLVFAVIATVLFTVGWIWAPVLWWIALGMTVYGLIYFVLHDGLVHQRWPFRY
                     IPRKGYARRLYQAHRLHHAVEGRDHCVSFGFIYAPPVDKLKQDLKMSGVLRAEAQERT"
     gene            2954..4114
                     /gene="crtY"
     CDS             2954..4114
                     /codon_start=1
                     /gene="crtY"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /note="lycopene beta-cyclase"
                     /product="lycopene cyclase"
                     /protein_id="BAE47467.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 1.1e-129,
                     bitscore: 421.9, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHDVLLAGAGLANGLIALALRAARPDLRVLLLDHAAGPSDGHTW
                     SCHDPDLSPDWLARLKPLRRANWPDQEVRFPRHARRLATGYGSLDGAALADAVVRSGAE
                     IRWDSDIALLDAQGATLSCGTRIEAGAVLDGRGAQPSRHLTVGFQKFVGVEIETDRPHG
                     VPRPMIMDATVTQQDGYRFIYLLPFSPTRILIEDTRYSDGGDLDDDALAAASHDYARQQ
                     GWTGAEVRRERGILPIALAHDAAGFWADHAAGPVPVGLRAGFFHPVTGYSLPYAAQVAD
                     VVAGLSGPPGTDALRGAIRDYAIDRARRDRFLRLLNRMLFRGCAPDRRYTLLQRFYRMP
                     HGLIERFYAGRLSVADQLRIVTGKPPIPLGTAIRCLPERPLLKENA"
     gene            4111..5616
                     /gene="crtI"
     CDS             4111..5616
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 418.7; E-value: 6.4e-127)"
                     /gene_kind="biosynthetic-additional"
                     /product="phytoene desaturase"
                     /protein_id="BAE47468.1"
                     /sec_met_domain="DAO (E-value: 1.3e-10, bitscore: 30.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAHSPAAKTAIVIGAGFGGLALAIRLQSAGIATTLVEARDKPGG
                     RAYVWHDQGHLFDAGPTVITDPDALKELWALTGQDMARDVTLMPVSPFYRLMWPGGKVF
                     DYVNEADQLERQIAQFNPDDLEGYRRFRDYAEEVYQEGYVKLGTVPFLKLGQMLKAAPA
                     LMKLEAYKSVHAKVATFIKDPYLRQAFSYHTLLVGGNPFSTSSIYALIHALERRGGVWF
                     AKGGTNQLVAGMVALFERLGGQMLLNAKVARIDTDGPRATGVTLADGRALTADMVASNG
                     DVMHNYRDLLGHTARGQSRAKSLNAKRWSMSLFVLHFGLREAPKDVAHHTILFGPRYKE
                     LVNEIFKGPKLAEDFSLYLHSPCTTDPEMAPPGMSTHYVLAPVPHLGRADIDWAVEGPR
                     YADRILASLEERLIPNLRANLTTTRIFTPSDFASELNAHHGSAFSVEPILTQSAWFRPH
                     NRDKTIRNFYLVGAGTHPGAGIPGVVGSAKATAQVMLSDLASA"
     gene            5613..6527
                     /gene="crtB"
     CDS             5613..6527
                     /codon_start=1
                     /gene="crtB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /product="phytoene synthase"
                     /protein_id="BAE47469.1"
                     /sec_met_domain="phytoene_synt (E-value: 2.8e-47, bitscore:
                     150.2, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDLVLTSTEAITQGSQSFATAAKLMPPGIRDDTVMLYAWCRHAD
                     DVIDGQALGSRPEAVNDPQARLDGLRADTLAALQGDGPVTPPFAALRAVARRHDFPQAW
                     PMDLIEGFAMDVEARDYRTLDDVLEYSYHVAGIVGVMMARVMGVRDDPVLDRACDLGLA
                     FQLTNIARDVIDDARIGRCYLPGDWLDQAGARVDGPVPSPELYTVILRLLDAAELYYAS
                     ARVGLADLPPRCAWSIAAALRIYRAIGLRIRKGGPEAYRQRISTSKAAKIGLLGIGGWD
                     VARSRLPGAGVSRQGLWTRPHHA"
     gene            complement(6524..7405)
                     /gene="crtE"
     CDS             complement(6524..7405)
                     /codon_start=1
                     /gene="crtE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 170.1; E-value:
                     9.5e-52)"
                     /gene_kind="biosynthetic-additional"
                     /note="geranylgeranyl diphosphate synthase"
                     /product="GGPP synthase"
                     /protein_id="BAE47470.1"
                     /transl_table=11
                     /translation="MRRDVNPIHATLLQTRLEEIAQGFGAVSQPLGAAMSHGALSSGKR
                     FRGMLMLLAAEASGGVCDTIVDAACAVEMVHAASLIFDDLPCMDDAGLRRGQSATHVAH
                     GESRAVLGGIALITEAMALLAGARGASGTVRAQLVRILSRSLGPQGLCAGQDLDLHAAK
                     NGAGVEQEQDLKTGVLFIAGLEMLAVIKEFDAEEQTQMIDFGRQLGRVFQSYDDLLDVV
                     GDQAALGKDTGRDAAAPGPRRGLLAVSDLQNVSRHYEASRAQLDAMLRSKRLQAPEIAA
                     LLERVLPYAARA"
     gene            complement(7571..8818)
                     /gene="crtX"
     CDS             complement(7571..8818)
                     /codon_start=1
                     /gene="crtX"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 88.1;
                     E-value: 1.2e-26)"
                     /gene_kind="biosynthetic-additional"
                     /note="zeaxanthin glucosyltransferase"
                     /product="carotenoid glucosyltransferase"
                     /protein_id="BAE47471.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.3e-14,
                     bitscore: 42.5, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVAASVAQRPRILFLHLSGPGQFEFLGRWLAGQGWDVTFMHGGI
                     DADPAHDGIRTRRFALRDTTIPTGDPRHILDHAAQNCRGATELMFRMRHSEGYVPDVVV
                     AHAGWGVGLGVKLVWPDCTYVAYHEWYYTDRNWDKRRAEKPADLAVMISDRMRNLPITG
                     EFDLADASWCPTLFQASRFPPVLRRQITVMPDGVDCDLHRPDPQARIDFDWLRLPADRP
                     VITYATRGMEPLRGFPQFLRGVARLQARRDDFDTVILANDSVSYGRPLARGDSWWLRMI
                     DQLDLDHRRIHVNAMRPRDEYVRTLQASHAHVYFTEPFVTSWSLSEAMATGCLVIGSNT
                     APVRELVRDMENGLIVDMDDADEVADAMAWVLDNPGDAADLRRAARRTILADHDAARVF
                     PAKDAWLRAAIGAPVH"
ORIGIN
        1 aagcttcatt aagcctgtcc atataacgga gaatgtcttg agccgttgcc aaggtagtta
       61 ttgtttttcg cagcctctta atatggccaa tatttttttc ataatatgct tgagcatcgt
      121 tttctgtaaa acccactgac cctcgccctg ttctccaaac gctttgactc gcgcagatca
      181 ctcctaccca tactaagggt aagattcttg tagtggggat ttgtgtaggc ttgaaagggt
      241 cttgagggaa ctgacctttg catggcgtgt gtgatgcaaa cgtgtgttgt cagcgtgtgt
      301 ggtcagtatc ccttaacaca cggaaatata acaataaagg tgtgatggcg gagacgaagg
      361 gattcgaacc ctcgagaccc tttcgggcct gcacccttag caggggtgtg ccttcgacca
      421 ctcggccacg tctccgccga cccgtatatg gatgtcgcca agggggggca aggggctttc
      481 tggccccttt ttgcagatct ccgcgcggcg ccgtccaagg ggttcgacgg cgccgggccg
      541 tggcgcgcga cagttcgtcc tcttggaact ggggctggaa cccggaaggc attgacgcga
      601 tagtcggatg acgcaaccgg atggcaggac atgaccgaaa tctctcgtcg caagtcggat
      661 cacctgcgca tcgtcaccga aggccgcggg gcgcaggacc ggctggacag cgggttcgac
      721 caggtccggt tcctgcatca ggcgctgcct gatctggaca tggatgccgt cgacacggga
      781 acgcggttcc tgggacgcag cctgggggcg ccactgctga tctcggccat gaccggcggt
      841 ccggaggagg cggaacgcat caacctgcat atcgccgagg cctgtgccca tcaccgcatc
      901 gccctgtccg tcggatcgca gcgcatcgcg gtcgaggcgg gcggcaatgg cggcctgggc
      961 gccagcctgc gggcacgggc gccccagatt ccgatcctgg gcaatatcgg cgcggtccag
     1021 ctgaactatg gttttggcgt ggcgcaggcg cagcgcgcgg tggacatgat ccaggccgac
     1081 gcgctgatcc tgcacctgaa cccgctgcag gaggcgatcc aggagggggg cgaccgcaat
     1141 tttgcggccc tgctgccgcg gatcgaggaa ctggccacca gcctgccggt ccccctgggc
     1201 gtcaaggagg tcggtgcggg gctgtcggcg cccgtggcgc gctgtctgat cgacgcgggc
     1261 gtgacgatcc tggacgtcgc cggcgccggc ggcaccagct gggcgcgtgt cgaggccgaa
     1321 cgcggtcccg accgcctgca ggcgctggcg gcgccgttcc acgactgggg catccccacg
     1381 accgcgtcgc tgcgcgccat cgcgccgatg atggggccgg accggattct ggtcgggtcg
     1441 ggcggggtgc gtcacggact ggacgccgcg cgggccatcc gccttggcgc ggacctcgtg
     1501 gggcaggcgg cccgcgctct gcccgccgcg cgccacagcg ccgaggccct gtccgatcac
     1561 ctgtccgacg tggtgaccca gctgcgcatc gcgatgttct gcacgggatc cggcgacctt
     1621 gcggcgctgc gccgcgcgcc tttgctggtg cctgggccgg gtggccaatg gtcgcaagca
     1681 acggggatgg aaaccggcga tgcgggactg tagtctgcgc ggatcgccgg tccgggggac
     1741 aagatgagcg cacatgccct gcccaaggca gatctgaccg ccaccagcct gatcgtctcg
     1801 ggcggcatca tcgccgcttg gctggccctg catgtgcatg cgctgtggtt tctggacgca
     1861 gcggcgcatc ccatcctggc gatcgcaaat ttcctggggc tgacctggct gtcggtcgga
     1921 ttgttcatca tcgcgcatga cgcgatgcac gggtcggtgg tgccggggcg tccgcgcgcc
     1981 aatgcggcga tgggccagct tgtcctgtgg ctgtatgccg gattttcgtg gcgcaagatg
     2041 atcgtcaagc acatggccca tcaccgccat gccggaaccg acgacgaccc cgatttcgac
     2101 catggcggcc cggtccgctg gtacgcccgc ttcatcggca cctatttcgg ctggcgcgag
     2161 gggctgctgc tgcccgtcat cgtgacggtc tatgcgctga tccttgggga tcgctggatg
     2221 tacgtggtct tctggccgct gccgtcgatc ctggcgtcga tccagctgtt cgtgttcggc
     2281 acctggctgc cgcaccgccc cggccacgac gcgttcccgg accgccacaa tgcgcggtcg
     2341 tcgcggatca gcgaccccgt gtcgctgctg acctgctttc actttggcgg ttatcatcac
     2401 gaacaccacc tgcacccgac ggtgccgtgg tggcgcctgc ccagcacccg caccaagggg
     2461 gacaccgcat gaccaatttc ctgatcgtcg tcgccaccgt gctggtgatg gagttgacgg
     2521 cctattccgt ccaccgctgg atcatgcacg gccccctggg ctggggctgg cacaagtccc
     2581 accacgagga acacgaccac gcgctggaaa agaacgacct gtacggcctg gtctttgcgg
     2641 tgatcgccac ggtgctgttc acggtgggct ggatctgggc gccggtcctg tggtggatcg
     2701 ccttgggcat gactgtctat gggctgatct atttcgtcct gcatgacggg ctggtgcatc
     2761 agcgctggcc gttccgttat atcccgcgca agggctatgc cagacgcctg tatcaggccc
     2821 accgcctgca ccatgcggtc gaggggcgcg accattgcgt cagcttcggc ttcatctatg
     2881 cgcccccggt cgacaagctg aagcaggacc tgaagatgtc gggcgtgctg cgggccgagg
     2941 cgcaggagcg cacgtgaccc atgacgtgct gctggcaggg gcgggccttg ccaacgggct
     3001 gatcgccctg gcgctgcgcg cggcgcggcc cgacctgcgc gtgctgctgc tggaccatgc
     3061 cgcaggaccg tcagacggcc acacctggtc ctgccacgac cccgacctgt cgccggactg
     3121 gctggcgcgg ctgaagcccc tgcgccgcgc caactggccc gaccaggagg tgcgctttcc
     3181 ccgccatgcc cggcggctgg ccaccggtta cgggtcgctg gacggggcgg cgctggcgga
     3241 tgcggtggtc cggtcgggcg ccgagatccg ctgggacagc gacatcgccc tgctggatgc
     3301 gcagggggcg acgctgtcct gcggcacccg gatcgaggcg ggcgcggtcc tggacgggcg
     3361 gggcgcgcag ccgtcgcggc atctgaccgt gggtttccag aaattcgtgg gtgtcgagat
     3421 cgagaccgac cgcccccacg gcgtgccccg cccgatgatc atggacgcga ccgtcaccca
     3481 gcaggacggg taccgcttca tctatctgct gcccttctct ccgacgcgca tcctgatcga
     3541 ggacacgcgc tattccgatg gcggcgatct ggacgacgac gcgctggcgg cggcgtccca
     3601 cgactatgcc cgccagcagg gctggaccgg ggccgaggtc cggcgcgaac gcggcatcct
     3661 tcccatcgcg ctggcccatg atgcggcggg cttctgggcc gatcacgcgg cggggcctgt
     3721 tcccgtggga ctgcgcgcgg ggttctttca tccggtcacc ggctattcgc tgccctatgc
     3781 ggcacaggtg gcggacgtgg tggcgggtct gtccgggccg cccggcaccg acgcgctgcg
     3841 cggcgccatc cgcgattacg cgatcgaccg ggcgcgccgc gaccgctttc tgcgcctttt
     3901 gaaccggatg ctgttccgcg gctgcgcgcc cgaccggcgc tataccctgc tgcagcggtt
     3961 ctaccgcatg ccgcatggac tgatcgaacg gttctatgcc ggccggctga gcgtggcgga
     4021 tcagctgcgc atcgtgaccg gcaagcctcc cattcccctt ggcacggcca tccgctgcct
     4081 gcccgaacgt cccctgctga aggaaaacgc atgaacgccc attcgcccgc ggccaagacc
     4141 gccatcgtga tcggcgcagg ctttggcggg ctggccctgg ccatccgcct gcagtccgcg
     4201 ggcatcgcca ccaccctggt cgaggcccgg gacaagcccg gcgggcgcgc ctatgtctgg
     4261 cacgatcagg gccatctctt cgacgcgggc ccgaccgtca tcaccgaccc cgatgcgctg
     4321 aaagagctgt gggccctgac cgggcaggac atggcgcgcg acgtgacgct gatgccggtc
     4381 tcgcccttct atcggctgat gtggccgggc gggaaggtct tcgattacgt gaacgaggcc
     4441 gatcagctgg aacgccagat cgcccagttc aacccggacg acctggaggg ataccgccgc
     4501 ttccgtgatt acgctgagga ggtgtaccag gagggctacg tcaagctggg caccgtgccc
     4561 ttcctcaagc tgggccagat gctcaaggcc gcgcccgcgc tgatgaagtt ggaggcctac
     4621 aagtcggtcc atgccaaggt cgcgaccttc atcaaggacc cctatctgcg gcaggcgttt
     4681 tcgtatcaca cgctgctggt gggcgggaat cccttctcga ccagctcgat ctatgcgctg
     4741 atccacgcgc tggagcggcg cggcggggtc tggttcgcca agggcggcac caaccagctg
     4801 gtcgcgggca tggtcgcgct gttcgaacgg cttggcgggc agatgctgct aaacgccaag
     4861 gtcgcgcgga tcgacacgga cgggccgcgc gcgaccggcg tgaccctggc cgacgggcgc
     4921 gccttgaccg ccgacatggt cgccagcaac ggcgacgtga tgcacaacta tcgcgacctg
     4981 ctgggccata ccgcccgcgg gcagagccgg gcgaaatcgc tgaacgcgaa gcgctggtcc
     5041 atgtcgctct tcgtgctgca tttcggcctg cgcgaggcgc ccaaggacgt ggcgcatcac
     5101 accatcctgt tcggcccccg ctacaaggag ctggtcaacg agatcttcaa gggcccgaag
     5161 ctggccgagg atttctcgct ctatctgcat tcgccctgca cgaccgaccc ggagatggcg
     5221 cctccgggca tgtccacgca ttacgtcctg gccccggtgc cgcatctggg ccgcgcggac
     5281 attgattggg cggtcgaggg gccgcgctat gccgaccgca tcctggccag cctggaggag
     5341 cggctgatcc cgaacctgcg cgccaacctg accacgacgc gcatcttcac cccgtccgat
     5401 ttcgccagcg aactgaacgc ccatcatggc agcgccttct cggtcgagcc gatcctgacg
     5461 caatccgcgt ggttccggcc gcacaaccgc gacaagacga tccgcaactt ctatctggtc
     5521 ggcgcgggca cccatccggg cgcggggatt ccgggcgtcg tgggctcggc caaggccacg
     5581 gcccaggtga tgctgtccga cctggcgagc gcatgagcga tctggtcctg acctcgaccg
     5641 aggcgatcac ccaagggtcg caaagctttg ccacggcggc caagctgatg ccgccgggca
     5701 tccgcgacga cacggtgatg ctctatgcct ggtgccgcca cgcggatgac gtgatcgacg
     5761 gtcaggccct gggcagccgc cccgaggcgg tgaacgaccc gcaggcgcgg ctggacggcc
     5821 tgcgcgccga cacgctggcc gcgttgcagg gcgacggtcc ggtgaccccg ccctttgccg
     5881 cgctgcgcgc ggtggcgcgg cggcatgatt ttccgcaggc ctggcccatg gacctgatcg
     5941 aaggctttgc gatggatgtc gaggcgcgcg actatcgcac gctggacgac gtgctggaat
     6001 attcctatca cgtcgcgggc atcgtcggcg tgatgatggc ccgtgtgatg ggcgtgcgcg
     6061 acgatcctgt cctggaccgt gcctgcgacc tggggctggc gttccagctg accaacatcg
     6121 cgcgcgacgt gatcgacgac gcgcgcatcg ggcggtgcta tctgccaggc gactggctgg
     6181 atcaggcggg cgcgcgggtc gacgggccgg tgccgtcgcc ggagctgtac accgtgatcc
     6241 tgcgcctgct ggatgcggct gaactctatt acgcgtcggc gcgggtgggt ctggcggatc
     6301 tgccgccgcg ctgcgcctgg tccatcgccg ccgcgttgcg gatctatcgc gccatcgggc
     6361 tgcgcatccg caagggcggg ccggaggcct atcgccagcg gatcagcacg tccaaggccg
     6421 ccaagatcgg gctgctgggc atcgggggct gggatgtcgc gcgatcacgc ctgccggggg
     6481 cgggcgtgtc gcgacagggc ctctggaccc ggccgcatca cgcctaggcg cgcgcggcgt
     6541 agggcagaac ccgttccagc agggccgcga tttccggagc ctgaaggcgc ttgctgcgca
     6601 gcatcgcgtc cagctgggcg cggctggcct catagtggcg ggacacgttc tgcaggtctg
     6661 acacggccag aaggccgcgc cgcgggccgg gggccgcggc atcgcgaccg gtatccttgc
     6721 caagcgccgc ctggtcgccc acgacgtcca gcaggtcgtc ataggactgg aacacccggc
     6781 ccagctgacg gccaaagtcg atcatctggg tctgctcctc ggcgtcgaac tccttgatca
     6841 cggccagcat ctccagcccg gcgatgaaca gcacgccggt cttcaggtcc tgttcctgtt
     6901 cgacccccgc gccgttcttg gccgcgtgca ggtccaggtc ctggccggcg cacaggccct
     6961 gcggccccag ggaccgcgac aggatccgca ccagctgcgc ccgcaccgtg cccgacgcgc
     7021 cgcgcgcacc ggccagcagg gccatcgcct cggtgatcag ggcgatgccg cccagcacgg
     7081 cgcggctttc gccatgcgcc acatgggtcg cggactggcc gcggcgcagc ccggcatcgt
     7141 ccatgcaggg caggtcgtcg aagatcagcg atgcggcatg caccatctcg accgcgcagg
     7201 cggcgtcgac gatcgtgtcg cagaccccgc ccgaggcctc tgccgcaagc agcatcagca
     7261 tgccgcggaa ccgcttgccc gacgacagcg cgccatggct catggccgcg ccgagcggct
     7321 gcgacacggc accgaatccc tgggcgatct cctcaagtct ggtctgcaga agggtggcgt
     7381 ggatcgggtt gacgtctcgt ctcatcagtg ccttcgcgct tgggttctga cctggcggga
     7441 aggtcaggcc ggggcggcac cccgtgaccc gtcatccacc gtcaacagtc cccatgttgg
     7501 aacggttcac gcccgattgc gagccttttc gacggcgacg cggggtcgcg cggcaatttg
     7561 tccaacaagg tcagtggacc ggcgcgccga tggccgcgcg cagccaggca tccttggccg
     7621 gaaacacccg cgccgcatca tgatcggcca ggatcgtccg gcgcgcggcg cggcgcaggt
     7681 cggccgcgtc acccggattg tcaagcaccc aggccatcgc atccgcgacc tcgtccgcgt
     7741 cgtccatgtc gacgatcagg ccgttctcca tgtcgcggac cagttcgcgc accggggcgg
     7801 tgttcgatcc gatcaccagg catccggtgg ccatcgcctc ggacagggac caggaggtga
     7861 cgaagggctc ggtgaaatag acatgcgcgt gcgaggcctg cagcgtgcgg acatattcat
     7921 cgcgcgggcg catggcgttc acgtggatgc ggcggtgatc caggtccagc tggtcgatca
     7981 tccgcagcca ccagctgtcg ccgcgcgcca gcggtcggcc ataggacacg ctgtcattgg
     8041 ccaggatcac cgtgtcgaag tcgtcacgcc gcgcctgcag gcgggcgacg ccgcgcagga
     8101 attgcggaaa gccgcgcaag ggctccatcc cgcgggtggc ataggtgatc acggggcggt
     8161 cggcgggcag gcgcagccag tcgaaatcga tgcgcgcctg cgggtcgggg cggtgcaggt
     8221 cgcaatcgac cccatccggc atcacggtga tctggcggcg caggaccgga ggaaagcggc
     8281 tggcctggaa cagcgtcggg caccagctgg catcggccag gtcgaattcg ccggtgatcg
     8341 gcaggttgcg catccggtcc gagatcatca ccgccaggtc ggcgggcttt tccgcccggc
     8401 gcttgtccca gttgcggtcg gtgtaatacc attcgtgata ggcgacatag gtgcagtccg
     8461 gccagaccag cttgaccccc agccccacgc cccagcccgc atgggccacc acgacgtccg
     8521 ggacatagcc ttcggaatgg cgcatgcgga acatcagctc ggtcgcgccc cggcagttct
     8581 gcgcggcgtg gtccaggatg tgacgcggat cgcccgtggg gatcgtggtg tcgcgcagcg
     8641 cgaatcggcg ggtgcggatg ccgtcatggg cagggtcggc gtcgatgccg ccatgcatga
     8701 aggtgacgtc ccagccctgg cccgccagcc agcggcccag gaactcgaac tgaccggggc
     8761 cggacaggtg cagaaacagg atacgcggcc gctgcgccac ggatgcggcg accgtcatga
     8821 ccggggaacc gtctgccagc ccgtgcagcc cgccgccagc agcggctgct gatcggtgcg
     8881 gttcacgatg gcctgcacgc gggcatgggc gacgcccagg tccagccgcg ccttggtcgc
     8941 gaccaggaac gtcgcatcgc cgtccatgac cgcgtggacc gcgggaaacg ccgcctgcag
     9001 caggtcgcgg atcgcgggca gggggcccgt tccatggatc agcaggacgc cgccgtcgcc
     9061 cgacaggcgc cgcccggcgt ggcggatgcg cgccagcgcg tccgcaccat gcagccagtc
     9121 ctcatccgcc ctggcgacga tcgcatccag ccgcggcgca tcgggtgccg catccgacag
     9181 ctgcgctggc cggaacgccg cgccaaggtc aagcgcctgg atcgctgcca ggggccagcc
     9241 cgccgcgggg tgatgcaccg tcaggccggg caccagggcc agcgccgcaa tggccagcgg
     9301 cagatgcgcc ggccctgtca ccatcacgtg ccgcagggcc gatgtcgcgc agagcagccc
     9361 aaggcagcga cgcgcccaac cctcgaccgg catggccggg ttcagcgcgt cgatcatgcc
     9421 caggggggtg ccgtcgtcgt ccagcacctg cacccggcgg tcatccagca tgcgcagcgc
     9481 cgcgccatcc aggcggtgca ggccgtgatt gatcgcccgc gcgcgggccc ggaccggggc
     9541 gtcggtcgcc cgcagccaag cgcggtggaa gggcgtgacc caggaaaacg catcgcggtt
     9601 gtccagcagc tcgaccgcct gctggacggc gatggccagc ggaccgtcca ggtccaaaga
     9661 caggggcagg ccgccgggct gcgtaccggc cagggtcacg cgccgcgcac gccaggcatg
     9721 gcgctggacg gggccggtct ggagccgcgt ctcggcacgg ttcaggtgca ggtcggacag
     9781 cgacgacagg cgggggttca gcacgtggat caggtccgcc ccgcgccgca gggccagcag
     9841 gcgcaccggc acgccaaggg cgggggcaca gacgcatccg tcgccgctgc ccgtcagcgc
     9901 atcgcccagc aggcgcattg cgacaccggt cagcggatcg tcggcccgcg cctctgccgg
     9961 gcgcaggcca agtctggggt cgtcatgggt cagctgggcg gtcatcgtgg ggcccgcgcg
    10021 gacattacag ccgactgaag aaggcgccgc ccagaggcgt ggcgccaccc gcgg
//
