LOCUS       BGC0000642              9127 bp    DNA     linear   BCT 06-DEC-2005
DEFINITION  Enterobacteriaceae bacterium DC413 carotenoid synthesis gene
            cluster, complete sequence.
ACCESSION   BGC0000642
VERSION     BGC0000642
KEYWORDS    .
SOURCE      Enterobacteriaceae bacterium DC413
  ORGANISM  Enterobacteriaceae bacterium DC413
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 13:58:29
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9127
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..9127
                     /db_xref="taxon:338907"
                     /mol_type="genomic DNA"
                     /organism="Enterobacteriaceae bacterium DC413"
                     /strain="DC413"
     protocluster    1..9127
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[5018:8582]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5019..8582
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..9127
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..9127
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000642"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..9127
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1772..2680
                     /gene="crtE"
     CDS             1772..2680
                     /codon_start=1
                     /function="converts farnesyl pyrophosphate (FPP) to
                     geranylgeranyl pyrophosphate (GGPP)"
                     /gene="crtE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 183.6; E-value:
                     7.2e-56)"
                     /gene_kind="biosynthetic-additional"
                     /note="GGPP synthase"
                     /product="geranylgeranyl pyrophosphate synthase"
                     /protein_id="AAZ73145.1"
                     /transl_table=11
                     /translation="MTIFAERDSTLIYSDPLMLLAIIEQRLDRLLPVESERDCVGLAMR
                     EGALAPGKRIRPVLLMLAAHDLGYRDELSGLLDFACAVEMVHAASLILDDIPCMDDAEL
                     RRGRPTIHRQFGEPVAILAAVALLSRAFGVIALADGISSQAKTQAVAELSHSVGIQGLV
                     QGQFLDLTEGGQPRSADAIQLTNHFKTSALFSAAMQMAAIIAGAPLASREKLHRFARDL
                     GQAFQLLDDLTDGQSDTGKDAHQDVGKSTLVNMLGSKAVEKRLRDHLRRADRHLASACD
                     SGYATRHFVQAWFDKKLAMVG"
     misc_feature    1772..9054
                     /note="carotenoid synthesis gene cluster"
     gene            2715..3749
                     /gene="idi"
     CDS             2715..3749
                     /codon_start=1
                     /function="catalyzes the isomerization reaction from
                     isopentenyl pyrophosphate isomerase (IPP) to dimethylallyl
                     diphosphate (DMAPP)"
                     /gene="idi"
                     /note="IPP isomerase"
                     /product="isopentenyl pyrophosphate isomerase"
                     /protein_id="AAZ73146.1"
                     /transl_table=11
                     /translation="MKDTDLTKRKNDHLDIVLRNTAPASGSFARWHFTHCALPELHLDQ
                     IDLRTRLFDRPMQAPFLISSMTGGAARALSINHHLAEAAQTLGLALGVGSQRVALESDN
                     DSGLTRDLRRIAPDIPLLANLGAAQILGEQGRRLARNAVSMIEADALIVHLNPLQEALQ
                     RGGDRDWRGVLQAIAQLVKSLEVPVVVKEVGAGISAEVAQRLAEAGVSMIDIAGAGGTS
                     WAAVEGERASTPQQRAVAMAFASWGIPTDEALRAVRDRLPAIPLIASGGIRDGIDAAKA
                     LRLGADIVGQAAAVLSSALHSTDAVVAHFNTLIEQLRVACFCTGSANLRQLRLAPLHRA
                     GETL"
     gene            3746..5035
                     /gene="crtX"
     CDS             3746..5035
                     /codon_start=1
                     /function="converts zeaxanthin to zeaxanthin glucosides"
                     /gene="crtX"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062:glycosyltransferase, MGT family (Score: 184.9;
                     E-value: 4.9e-56)"
                     /gene_kind="biosynthetic-additional"
                     /note="glucosylase"
                     /product="zeaxanthin glucosyl transferase"
                     /protein_id="AAZ73147.1"
                     /sec_met_domain="MGT (E-value: 3e-35, bitscore: 111.0,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHFAAIAPPFYSHVRALQALAQSLIARGHRVTFIQQAEVATLLS
                     DAAIGFHAIGLETHPVGTLDRTLALAAHPGGLGILRLIRDMASSTDMLCRELPEALRAL
                     AVDGVIVDQMAPAGGLVAEALRLPFVSVACALPVNREAHFPLPVMPFLWGTSSAARERF
                     ASSEKIYDWLMRSHDRVLARHADAFGLADRRQPHQCLSPLAQISQLPHALDFPRRELPA
                     HFHATGPLREPPAAAAAPLFSNRGQPRIFASLGTLQGGRYGLFKTLAKACRELEAELLI
                     AHCGGLSDFQARKLLRAGAAQVAAFVNQRAALAQADVAITHGGLNTVLDAVTYGTPLLA
                     IPLAFDQPGIAARLAHHGLGMRASRFSTSHQIARRLRRLLDDGAVKQRMTRLQPQLAAC
                     GGVERAAEITERALLTRQPVRAEKYYDIAV"
     gene            5019..6182
                     /gene="crtY"
     CDS             5019..6182
                     /codon_start=1
                     /function="catalyzes the terminal cyclization reaction from
                     lycopene to beta-carotene"
                     /gene="crtY"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /product="lycopene cyclase"
                     /protein_id="AAZ73148.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 3.5e-128,
                     bitscore: 416.7, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSQYDLLLLGAGLANGLLALRLKALQPQLRVLVLDAHAHAGGNH
                     TWCFHEEDLSAAQHQWIAPLVAHRWPHYEVRFPALTRQLNSGYFCVTSARFDEVLRATL
                     GDALRLNQTVASSGPDHVQLASGEVLRARAVIDGRGYQPDAALQIGFQSFVGQEWRLSQ
                     PHQLEGPILMDAAVDQQGGYRFVYTLPLSPTRLLIEDTHYINDASLATAQARQNICDYA
                     TRQGWQLETLLREERGALPITLAGDFDRFWHHRAPCVGLRAGLFHPTTGYSLPLAATLA
                     DALAAEADFSPEALAPRIHRFAQAAWRKQGFFRMLNRMLFLAAEGDRRWRVMQRFYGLP
                     EGLIARFYAGRLTLADRARILSGKPPVPVLAALQAILTHPSGRRASR"
     gene            6179..7660
                     /gene="crtI"
     CDS             6179..7660
                     /codon_start=1
                     /function="desaturates phytoene to lycopene"
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 418.5; E-value: 7.6e-127)"
                     /gene_kind="biosynthetic-additional"
                     /product="phytoene desaturase"
                     /protein_id="AAZ73149.1"
                     /transl_table=11
                     /translation="MKHTTVIGAGFGGLALAIRLQAAGVPTRLLEQRDKPGGRAYVYQD
                     QGFTFDAGPTVITDPSAIEELFALAGKSMRDYVELLPVTPFYRLCWETGEVFNYDNDQA
                     RLEAEIRKFNPADVAGYQRFLDYSRAVFAEGYLKLGTVPFLSFRDMLRAAPQLARLQAW
                     RSVYSKVASFIEDDKLRQAFSFHSLLVGGNPFATSSIYTLIHALEREWGVWFPRGGTGA
                     LVQGMLKLFQDLGGTLELNARVSHIEAKEAAISAVHLEDGRVFETRAVASNADVVHTYG
                     DLLGRHPAAAAQAKKLKGKRMSNSLFVLYFGLNHHHDQLAHHTVCFGPRYRELIDEIFN
                     RDGLAEDFSLYLHAPCVTDPSLAPPGCGSYYVLAPVPHLGTADLDWNVEGPRLRDRIFA
                     YLEEHYMPGLRSQLVTHRIFTPFDFRDQLNAYQGSAFSVEPILRQSAWFRPHNRDSHIR
                     NLYLVGAGTHPGAGIPGVIGSAKATASLMLEDLHA"
     gene            7653..8582
                     /gene="crtB"
     CDS             7653..8582
                     /codon_start=1
                     /function="converts two molecules of geranylgeranyl
                     pyrophosphate (GGPP) to phytoene"
                     /gene="crtB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /product="phytoene synthase"
                     /protein_id="AAZ73150.1"
                     /sec_met_domain="phytoene_synt (E-value: 7e-54, bitscore:
                     171.7, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHNPTLLHHAVETMEVGSKSFATASKLFDAKTRRSVLMLYAWCRH
                     CDDVIDDQQLGFPGEVPSAQTPQQRLANLERKTRQAYAGAQMHEPAFAAFQEVAIAHDI
                     SPAYAFDHLEGFAMDVRGARYETFQDTLRYCYHVAGVVGLMMAQIMGVRDEAVLDRACD
                     LGLAFQLTNIARDIVEDARVGRCYLPESWLEEAGLDRLHFADRAHRPALANLARRLVSE
                     AEPYYASASAGLAGLPLRSAWAIATAKEVYRRIGVKVYGAGETAWDRRQSTSKQEKLLL
                     LAAGAAQAIRSRAAASPPRPAELWQRPR"
     gene            complement(8521..9054)
                     /gene="crtZ"
     CDS             complement(8521..9054)
                     /codon_start=1
                     /function="catalyzes the hydroxylation reaction from
                     beta-carotene to zeaxanthin"
                     /gene="crtZ"
                     /product="beta-carotene hydroxylase"
                     /protein_id="AAZ73151.1"
                     /transl_table=11
                     /translation="MLWLWNAGIVLLTVVAMEITAALSHKYIMHGWGWGWHRSHHEPHS
                     GWFEVNDLYAVVFAGLAILLIYLGSRGVWPLQWIGAGMTLYGLLYFIVHDGLVHQRWPF
                     KYIPRRGYFKRLYMAHRLHHAVRGREDCVSFGFLYAPPLEKLQATLRQRHGRRPNADAA
                     RARQDAAEKQPPET"
ORIGIN
        1 cgcggctcgg tgcagcatac cgacccgcag ggcgagcgca cgccgctgtc ggctaaacgg
       61 gtgatggtgg taaatgcggg tgatggtctg cggcatgaag agtccgcgcc gctgattgaa
      121 gctgaactgt tgcaggcgtt tatccgcccg gcgcgcgccg gaggcgaagc gaaaaccctg
      181 aagctgctgc gcgcttgcgt ccgtcgccca taacgcctgg acatggctgg cggggccgga
      241 aggcagtgcc gcgccgctga cgctgcgtca ggcggtgcat atctacgacg tacggctgga
      301 gcgtggcaaa acgctggcgg tgcccgcgct gcccggcttc gcgccctggc tggcggtgct
      361 ggacggcgtg gtgaatctgg agggacagcg tctgcataaa ggggacgtgg ccggtgacgc
      421 cgacgcattg ccagaggtaa ccgccgagcg cgacgccacg ctgatctgtt ttctggtgga
      481 tgcggaagcg accggcgtga tgagcggaac cgttagcggc agttgataat aagggaaggt
      541 aaataccttc ccttttttat caggcgtggt gacgggcgcg ctgtagtcgg tgccggaact
      601 gacgtacctc ttcgcgcgac cagcagcgtt ctctgaacgc tacgttttgc agcggcgccg
      661 gcagtggtac cccatccagc gatccgcgat tgcagtaggc acgcaccagc ctcagcggag
      721 agacccccag gtagcgcgca acatcagaca gcgtcatcaa ttcacttttc atacccatct
      781 ccttttgcga gcgattcact gcatcttcga ttcctttcac cgcgcgttgt ttgatctggc
      841 gcattgaacc agtgattaaa ttttgagcaa ggcgtaaaaa ttcatcattt cttaactggc
      901 gaagcggcag attttcaccc aggcttgagg ctctttcctt ctgcgtgcga ggatgcgtga
      961 aactctaccc actgctgctt atcagcctgc tgtttcctct ccttgccgct gcacacagcg
     1021 ttgaaacggg aaaacctctt ccgccggtct ttatcgccaa cgagggcgag ctggtgatgc
     1081 agcatgagat gctgggctat cagcgctgga gcagccagtc gctgaccggc aaagtccgca
     1141 tggtgatcca cgtcgccggg cggctgtcgg ccaaagagca aaacgcgccg ctgatcgccg
     1201 ccgtccagca ggcaaacttt ccgcgcagcc gctttcagac caccactatc gtcaataccg
     1261 acgacgccat tccaggcagc gccatttttg tcgagcgcag cattaaatcg agcaagcgcg
     1321 acgcgccctg gcagcatttc gtgatcgaca gcagcggtgt ggcgcgcaac agctggcagc
     1381 tgacgccgca cggctccgcc gtgatgctgc tggacgcaca gggggtggtg cgcttcgcaa
     1441 gagatggcgc gctgacgccg caggaggtca ggcaggctat tgctttgctt aaccagctgc
     1501 tttccgctgc tgcggcgcca tccgacccgg cacttagttc gtgaataaaa ttattatttt
     1561 attatcactt atctccgttt tgcccgtcag caggcgaatt ctcgactacg ctttatttca
     1621 ccgtctcgcc aaaaccaaac aacaatgctg atctgcgacg acgctaaaaa taacaggttc
     1681 gacgttaatt attagatggc tctttctgcg ccactttgtt catttgcaat tacgacaggc
     1741 cgacgctcac ctgcaagtaa ggactgccat tatgaccatt tttgctgaaa gagactctac
     1801 tctcatctac agcgatcctc tgatgttact ggcgattatt gaacagcgtc ttgaccgact
     1861 gctgccggta gaaagcgaac gagactgcgt ggggctcgcc atgcgcgaag gcgcgctggc
     1921 accgggcaaa cgcatccggc cggtactgct gatgctggcc gctcacgacc ttggctatcg
     1981 cgacgaactc agcgggctgc tcgacttcgc ctgcgccgtc gagatggtgc atgccgcctc
     2041 gctgatactc gacgatattc cctgcatgga cgatgccgaa ctgcggcgcg gccggccgac
     2101 aatccatcgc cagttcggcg agccggtggc gattctcgcc gccgtcgccc tgctgagccg
     2161 cgccttcggc gtgattgcgc tggcggacgg catcagcagc caggcgaaga cccaggccgt
     2221 ggcggagctt tcccattcag tcggcattca ggggctggtg cagggacagt ttctcgatct
     2281 gaccgaaggc ggccagccgc gcagcgccga cgccattcag ctgaccaacc actttaaaac
     2341 cagcgcgctg ttcagcgcgg cgatgcagat ggccgccatc atcgccggcg cgccgctggc
     2401 gtcgcgtgaa aagctgcacc gcttcgcgcg ggatctcggc caggcctttc agctgctgga
     2461 cgacctgacc gacggccaga gcgacacggg aaaagatgcc catcaggacg tggggaaatc
     2521 gacgctggtg aacatgctgg gcagcaaagc ggtagaaaag cgcctgcgcg accatctgcg
     2581 acgcgccgat cgccacctcg cttcggcctg cgacagcggc tacgccaccc ggcacttcgt
     2641 gcaggcctgg ttcgataaaa aactcgctat ggtcggctga ccgcgcgttt cctgtctgag
     2701 tatatggagc agcaatgaag gacacggacc tgacgaagcg caaaaacgat catctggaca
     2761 ttgttctgcg taataccgcg ccggcgtcgg gcagcttcgc ccgctggcac tttacccact
     2821 gcgccctgcc ggagctgcac ctggatcaga tcgatctgcg cacgcggctg ttcgatcgcc
     2881 ccatgcaggc gccctttctt attagctcaa tgaccggcgg cgcggcgcgc gccctctcga
     2941 ttaatcatca tcttgccgaa gcggcgcaga cgctgggtct ggcgctgggg gtcggttcgc
     3001 agcgcgtggc gctggaaagc gacaacgatt ctggcctgac gcgcgattta cgccgtatcg
     3061 ccccggatat tccgctgctg gcgaacctcg gcgcggcgca gattctgggc gaacagggcc
     3121 gcaggctggc gcgaaatgcg gtaagcatga tcgaggcgga tgcgctgatc gtccatctta
     3181 atccgctgca ggaagcgctg cagcgcggcg gcgatcgcga ctggcgcggc gtactgcagg
     3241 cgattgcgca gctggtgaag tcgctggagg tgccggtggt ggtgaaagag gttggcgcgg
     3301 gcatctcggc cgaggttgcg cagcggctcg ccgaggcggg cgtcagcatg atcgatatcg
     3361 caggtgcggg cggcaccagc tgggcggcgg tagagggcga acgcgccagc accccgcagc
     3421 agcgcgcggt ggcgatggcc tttgccagct ggggtattcc cacagatgaa gccttacgcg
     3481 cggtgcgcga caggctgcct gccataccgc ttatcgcctc aggcggcatc cgcgacggca
     3541 tcgacgcggc gaaggcgctg cggctcggcg cggatatcgt tggccaggcg gcggcggtgc
     3601 tcagcagcgc cctgcactct acggatgcgg tggtcgcgca ctttaacacg ctgattgaac
     3661 agctgcgcgt cgcctgtttc tgcaccggca gcgctaatct gcgccagctg cgccttgcgc
     3721 cgctgcatcg cgccggagaa acgctatgag ccatttcgcc gcgatcgccc ctccctttta
     3781 cagccacgtg cgcgcgcttc aggcgctggc gcagagcctg atagcgcgcg gccatcgggt
     3841 gacctttatt cagcaggcgg aggttgccac cctgctcagc gacgccgcta tcggctttca
     3901 cgccatcggc ctggaaacgc atcctgtcgg cacgctcgac cgtacgctgg cgctggcggc
     3961 ccatcccggc ggcctgggca ttctgcgcct gatccgcgat atggccagca gcaccgatat
     4021 gctgtgccgc gagctgccgg aggcgctgcg ggcgctggcg gtagatggcg tgatcgtcga
     4081 tcagatggcg ccagcgggcg ggctggtggc ggaggcgctg cggctgccct tcgtttcggt
     4141 cgcctgcgcc ctgccggtca atcgtgaagc ccattttcca ttgccggtca tgcctttttt
     4201 gtggggtact agcagcgccg cgcgcgagcg gttcgcctcc agcgaaaaaa tttatgactg
     4261 gctgatgcgc agccacgatc gcgtgctggc gcgccatgcc gacgcctttg gccttgccga
     4321 ccgccgtcag ccgcaccagt gcctgtcgcc gctggcgcaa atcagccagc tgccgcacgc
     4381 cctcgacttt ccgcgccgcg agctgccggc ccatttccac gccaccggcc cgctgcgcga
     4441 accgcccgcc gctgccgcag cgccgctgtt cagtaaccgc ggccagccgc gcattttcgc
     4501 ctcgctcggc acgctgcagg gcggccgtta cgggctgttt aaaacgctgg caaaagcctg
     4561 ccgcgaactg gaggcggagc tgctgatcgc ccactgcggc ggcctgagcg attttcaggc
     4621 gcgtaaactg ctgcgcgccg gggcggcgca ggtagccgcc tttgtcaatc agcgcgccgc
     4681 gctggcgcag gcggacgtgg ccattaccca cggcggctta aatacggtgc tcgacgccgt
     4741 aacctatggc acgccgctgc tggcgattcc gctggcattc gatcagcccg gcattgccgc
     4801 gcggctggcg caccatggcc tggggatgcg cgcgtcgcgc ttctccacca gccatcagat
     4861 tgcgcgtcgc ctgcgtcgcc tgctggacga tggtgcggtt aagcagcgca tgacgcgcct
     4921 gcagccgcag ctggccgcct gcggcggcgt cgagcgcgcg gctgagatta ccgagcgcgc
     4981 gctgctgacg cgccagccgg tgcgcgcgga gaagtactat gacatcgcag tatgatctgc
     5041 tgttgctcgg cgccggtctg gcgaacgggc tgctggcgct gcggctgaaa gcgctccagc
     5101 cgcagctgcg cgtgctggtg cttgatgccc acgcccacgc cggtggcaat cacacctggt
     5161 gctttcacga agaggatctc agcgccgcgc agcatcagtg gattgcgccg ctggtggcgc
     5221 accgctggcc gcactacgag gtacgctttc ccgcgctgac gcgccagctt aacagcggct
     5281 atttttgcgt cacttccgcg cgctttgacg aggtgctgcg cgcgacgctc ggcgacgcgc
     5341 tgcggcttaa ccagaccgtc gccagcagcg gccccgatca cgtgcagctc gccagcggcg
     5401 aagtgctgcg cgcgcgcgcc gtcattgacg gccgcggcta tcagcccgac gccgccctgc
     5461 agattggctt tcagtctttt gtcggtcagg agtggcgcct gagccagccg catcagctgg
     5521 aggggccgat tctgatggac gcggccgtgg atcagcaggg gggctatcgc ttcgtctata
     5581 ccctgccgct ctcgccgacg cgtctgctga ttgaagatac ccactatatt aacgacgcct
     5641 cgctggcgac ggcgcaggcg cggcagaata tctgcgacta cgccacccgc cagggctggc
     5701 agctggagac gctgctgcgc gaagagcgcg gcgcgctgcc gattacgctg gcgggcgatt
     5761 tcgaccgctt ctggcatcat cgcgccccct gcgtcggcct gcgcgccggg ctttttcacc
     5821 ccacgaccgg ctactccctg ccgctggcgg cgacgctggc ggacgcgctc gccgcagagg
     5881 cggacttctc ccctgaggcg ctcgcgccgc gtattcaccg ctttgcgcag gcagcgtggc
     5941 gtaaacaggg ctttttccgc atgcttaacc gcatgctgtt cctggcggcc gagggcgatc
     6001 ggcgctggcg cgtaatgcag cgcttttacg gcctgcccga ggggctgatc gcccggtttt
     6061 acgccggacg gctgacgctg gccgaccgcg cgcgcattct tagcggcaag ccgccggtcc
     6121 cggtgctggc ggcgctgcag gctattctca cccacccttc tggacgaaga gcatcacgat
     6181 gaagcacacc acggtaattg gcgcaggatt tggcgggctg gcactggcaa ttcgcctcca
     6241 ggcagcaggc gttccaacgc ggctgctgga gcagcgcgac aagccgggcg gccgcgccta
     6301 tgtttatcag gatcagggct ttacctttga cgcgggcccg acggtgatca ccgatccgtc
     6361 cgctattgaa gagctgttcg ccctggcggg aaaatcgatg cgcgactatg tcgagctgct
     6421 gccggtgacc cctttttacc ggctctgctg ggagacgggc gaggtgttta actacgataa
     6481 cgatcaggcg cgactggaag cggagatccg caaatttaat ccagccgacg tggcgggcta
     6541 tcagcgcttc ctcgactatt cgcgcgccgt gttcgccgaa ggctacctga agctcggcac
     6601 cgtgcccttt ttgtcgttcc gcgatatgct gcgcgccgca ccgcagctgg cgcgcctgca
     6661 ggcgtggcgc agcgtttaca gcaaggtggc gagctttatc gaggatgata agctgcggca
     6721 ggccttttcg tttcactcgc tgctggtcgg cggcaacccc ttcgccacct cgtcgatcta
     6781 tacgctgatc cacgcgctgg agcgcgaatg gggcgtctgg tttccgcgcg gcggcaccgg
     6841 cgcgctggtg cagggcatgc tgaagctgtt ccaggattta ggcggcacgc tggagctgaa
     6901 cgcgcgcgtc agccatatcg aggcgaaaga ggccgcgatt tccgccgtgc atctggagga
     6961 tggtcgggta tttgaaaccc gcgcggtcgc ctctaacgcc gatgtggtgc atacctatgg
     7021 cgatctgctc ggcaggcacc ccgccgccgc cgcgcaggcc aaaaagctga aaggcaagcg
     7081 catgagcaac tcgctgtttg tgctctattt tggcctgaac catcatcacg atcagctggc
     7141 gcaccacacc gtctgcttcg ggccgcgcta ccgtgagctg attgacgaga tctttaaccg
     7201 cgacgggctg gcggaagatt tctcgctcta tctccatgcg ccctgcgtga ccgatccctc
     7261 gctggcgccg ccgggctgcg gcagctacta cgtgctggca ccggttcccc atcttggcac
     7321 cgccgatctc gactggaacg ttgaggggcc gcgcctgcgc gatcgcattt tcgcctatct
     7381 cgaagagcac tatatgcccg gcctgcgcag ccagctggtc actcaccgca tcttcacgcc
     7441 gttcgatttc cgcgaccagc ttaatgccta tcagggctct gcgttttccg ttgagccgat
     7501 tttgcgccag agcgcctggt tccggcccca taaccgcgac agccatatcc gcaatctcta
     7561 tctggtcggc gcgggtacgc acccaggcgc gggcattccc ggcgtgatcg gttccgccaa
     7621 agccaccgca agcctgatgc tggaggatct gcatgcataa tccgacgctg ctgcaccatg
     7681 ccgtagagac gatggaagtc ggttcgaaga gtttcgccac cgcctcaaag ctgttcgacg
     7741 cgaaaacgcg ccgcagcgtg ctgatgctct acgcctggtg ccgccactgt gatgatgtga
     7801 tcgatgacca gcagcttggc tttccaggcg aggttccttc ggcgcagacc ccgcagcagc
     7861 gtctggcaaa tctggagcgc aaaacccgcc aggcctacgc gggcgcgcaa atgcatgaac
     7921 ccgccttcgc cgcctttcag gaggtggcga tcgcccacga tatctctccc gcttacgctt
     7981 tcgaccatct ggaagggttt gcaatggacg tccgcggcgc gcgttatgaa acctttcagg
     8041 atacgctgcg ctactgctac cacgtggcgg gcgtggtggg attaatgatg gcgcagatta
     8101 tgggggtgcg cgacgaggcg gtgctggatc gcgcctgcga tctcggcctc gcctttcagc
     8161 tgaccaatat tgcacgcgat atcgttgagg atgcgcgagt cggccgctgc tatttgccgg
     8221 aaagctggct ggaggaggcc gggctggatc gtcttcactt tgccgatcgc gctcatcgcc
     8281 cggcgctggc gaatctggcg cggcggctgg tgagcgaggc ggagccctac tacgcctctg
     8341 cgtcggccgg gctggccggg ctgccgctgc gctctgcgtg ggcgatcgcc acggcgaaag
     8401 aggtttatcg ccgcattggg gttaaggtct acggcgcggg ggaaacggcc tgggatcgcc
     8461 gccagtccac cagcaagcag gagaagcttc tgctgctggc ggcgggggcg gcgcaggcga
     8521 tcaggtctcg ggcggctgct tctccgccgc gtcctgccga gctctggcag cgtccgcgtt
     8581 aggccgacgt ccgtgacgct gacgcagcgt cgcctgtaat ttctccagcg gcggcgcata
     8641 gaggaagccg aaggagacgc agtcttcccg gccgcgcacc gcatggtgca gccggtgcgc
     8701 catgtagagt cgtttaaagt agccgcgacg cggtatgtac ttaaaaggcc agcgctggtg
     8761 taccagcccg tcatgcacaa taaaatagag caggccgtaa agcgtcatgc ctgcgcctat
     8821 ccactgtagc ggccagacgc cgcggctgcc caggtagatc aacagaatcg ccagcccggc
     8881 gaacaccaca gcatagagat cgttcacttc aaaccagccg ctgtgcggtt catgatgcga
     8941 ccggtgccag ccccatcccc agccgtgcat aatatattta tgcgacagcg cggcggtaat
     9001 ctccatcgct acgacggtca gtaatacgat cccagcattc cacaaccaca gcatatcttc
     9061 tcccgtcagt gcatcctgcc agccagcgca ggctggccat catcagctgc ggcacgccgc
     9121 aggcgaa
//
