LOCUS       BGC0000643             10197 bp    DNA     linear   BCT 23-AUG-2006
DEFINITION  Brevundimonas vesicularis carotenoid synthesis gene cluster,
            complete sequence.
ACCESSION   BGC0000643
VERSION     BGC0000643
KEYWORDS    .
SOURCE      Brevundimonas vesicularis
  ORGANISM  Brevundimonas vesicularis
            Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
            Caulobacteraceae; Brevundimonas.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 20:07:18
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10197
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..10197
                     /db_xref="taxon:41276"
                     /mol_type="genomic DNA"
                     /organism="Brevundimonas vesicularis"
                     /strain="DC263"
     protocluster    1..10197
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[5663:9240]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5664..9240
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..10197
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..10197
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000643"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..10197
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(364..1113)
                     /gene="crtG"
     CDS             complement(364..1113)
                     /codon_start=1
                     /gene="crtG"
                     /product="2,2'-beta-ionone ring hydroxylase"
                     /protein_id="ABC50107.1"
                     /transl_table=11
                     /translation="MLKDLFVTTLALSLIIGVRYLLVGVVTHSLLWGGAGRGRQLNHRP
                     PAAKRIRAEVVASLIACPIYALPAAFVIEFWKRGGTAIYDDAHAWPLWWLPVSFIVYML
                     AHDAFYYWVHRALHHPRIFPWAHAEHHRSRDPSAFASFAFDPAEAIATAWFLPALTLFI
                     PIHWGVALALLTLMTATAVLNHAGREVWPASWLKRAPLRWMITATHHDAHHKRFNGNYG
                     LYFQMWDKWAGSEISQLDRPSPRNPLT"
     misc_feature    364..10046
                     /note="carotenoid synthesis gene cluster"
     gene            1188..1673
                     /gene="crtZ"
     CDS             1188..1673
                     /codon_start=1
                     /gene="crtZ"
                     /product="beta-carotene hydroxylase"
                     /protein_id="ABC50108.1"
                     /transl_table=11
                     /translation="MSWPTMILLFLATFLGMEVFAWAMHRYVMHGLLWTWHRSHHEPHD
                     DVLERNDLFAVVFAAPAIILVALGLHLWPWMLPIGLGVTAYGLVYFFFHDGLVHRRFPT
                     GIAGRSAFWTRRIQAHRLHHAVRTREGCVSFGFLWVRSARALKAELSQKRGSSSNGA"
     gene            complement(1640..2683)
                     /gene="idi"
     CDS             complement(1640..2683)
                     /codon_start=1
                     /gene="idi"
                     /product="isopentenyl pyrophosphate isomerase"
                     /protein_id="ABC50109.1"
                     /transl_table=11
                     /translation="MSTDADALIRRKDEHIDHVRAGRGVSQTTSGLDAVRFVHDALPDI
                     DHDAIDLATRFLGRRVALPFLISSMTGGPSRAEAINARLAEAAQALGVVLAVGSQRVAL
                     ETDGGLGLGLDLRRRAPDAMILANLGAVQFALGYGVDEARRAMEMIGADALILHLNPLQ
                     EGVQPEGDRDWRGVARGIERVAAAFPGRLIVKETGAGLSGAVARRLADMGVAALDVAGA
                     GGTNWGLIEGARATGGRAEALAAPFAAWGVPTARSLLNCAQAAPELDLIGSGGIRDGLD
                     AARAIRLGACLVGQAAGVLEAALTGTEAVVDHLDLMAAQLRLACFCTGSADLAALAQAP
                     LLDEPRF"
     misc_feature    complement(2198..2200)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2793..3689
                     /gene="crtE"
     CDS             2793..3689
                     /codon_start=1
                     /gene="crtE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 193; E-value:
                     1e-58)"
                     /gene_kind="biosynthetic-additional"
                     /product="geranylgeranyl pyrophosphate synthase"
                     /protein_id="ABC50110.1"
                     /transl_table=11
                     /translation="MAIVGIRRQTPLVGASCAPDDLRLQVQARLAEVAPAHDGLLSTAA
                     REALLGRGKRVRPVLAMLAAAHVGGDPEDALEYACALEMVHAASLVLDDLPCMDDASLR
                     RGQPTLHHRHGEDTAVLAAVALLNQATRLVLQTAAPAETRLAALDLLTQAIGFDGLSEG
                     QMRDLRDDARDRDESALRQINDLKTGALFVATVRGGGLLGGGDAQDLARLSIFGEAIGF
                     AFQLCDDLLDVCSTVDAAGKDVGQDDDTTTFVDLWGECRTRAAVRQSLGKAVEAVGHDS
                     PLAVYVLDLFQQAELGV"
     CDS             3745..4596
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 161; E-value:
                     6.2e-49)"
                     /gene_kind="transport"
                     /note="CDS3"
                     /product="unknown"
                     /protein_id="ABC50111.1"
                     /transl_table=11
                     /translation="MLRDFSLSIAAGEVYALLGANGAGKSTVARVACGLLPVRRGRVVL
                     GDGGGPRGRIGLAPQDSALFPALSPRENVDVTARLCGVPKRDRGAAVNRALNLTGCGPR
                     ADQPVRTLSGGWTRRANLSAALVGQPRLLIADEPTEGVDAATRGILSVALRETAKAGAG
                     CLLISHDAVFVADTADRIGVLAQGRLLAQGAPNALLHHAFGSARLLSIRLTRQASDPAA
                     QWFAQAGLTASEDGLEWRRLCDDALAIAQMLAAVVDGEDGEIAVRRPGLDDLVAQLSQA
                     PS"
     CDS             4596..5660
                     /codon_start=1
                     /note="CDS2"
                     /product="unknown"
                     /protein_id="ABC50112.1"
                     /transl_table=11
                     /translation="MAVXGAWARGFWRDRSGVILTLLLPPLXYLLFXAIFGAGARGDID
                     TTVVLHDASRTPATXAIREAVSKDMGARLRIVEDREAFDRAVIDGRADAGILIRPSTQG
                     PPKLVIVSAAGRDVAASALQARLEPMAAALSGQGARPAPRVQTLQIGPQGDVQATYYAG
                     AVSVMFVFFAAMHGAMGGLDERRSGLQSRLALARGGLAPILAGRAAWLTAVGMMQSAAV
                     FVAACVKLPALEPWQMAAAAVTALAVGFCAAGLALALTAACRSREQAQPLTTFVVLLLA
                     ALGGSMAPRFLMPEAFRELGWITPHAWAIEAYQAVIWRGEFTSTVIAAWAVMAGLGVSG
                     LGVALMLERRRAAR"
     gene            complement(5664..6596)
                     /gene="crtB"
     CDS             complement(5664..6596)
                     /codon_start=1
                     /gene="crtB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /product="phytoene synthase"
                     /protein_id="ABC50113.1"
                     /sec_met_domain="phytoene_synt (E-value: 2.9e-53, bitscore:
                     170.2, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDAVLDHSRQSMEQGSKSFAAAARLFPAAIRDDAWMLYSWCRHC
                     DDEIDGQVLGHGAVGIDPVLAGEKLDELRLRTAAALAGEPQTDPVFTAFQRVAMRHGIP
                     ADEAMDLLQGFEMDVVGRRYDTLEDTLDYAYHVAGVVGVMMARIMGVEDAPTLRRAQDL
                     GLAFQLTNIARDVVEDAKGGRVYLPGAWLDEAGVPRDQVDQPQHRAAVARTAQRLVAAA
                     EPFYASARWGLRDLNPRSAWAIATARGVYRSIGRHVSRAGVSAWDGRTSIDKAGKLMLL
                     GRGGLIALWCKTLDAWREPPPRPALWTHV"
     misc_feature    complement(5679..5681)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6593..8077)
                     /gene="crtI"
     CDS             complement(6593..8077)
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 434.2; E-value: 1.3e-131)"
                     /gene_kind="biosynthetic-additional"
                     /product="phytoene desaturase"
                     /protein_id="ABC50114.1"
                     /transl_table=11
                     /translation="MMRAAVIGSGFGGLSLAIRLQSAGIQTTVFEARDLEGGRAYVFKD
                     KGYTFDAGPTVITDPSALEELFEASGRKLSDYVELLPVAPFYRLCWEDGDVFDYVNDQD
                     ELDRQIVARNPADKEGYRKFLAYSQDLLKEGYLKLGAVPFLDFASMVKAAPELMRLQAW
                     RSVYDKVASYIQDEHLRQAFSFHSLLVGGNPFATSSIYALIHALERRWGVWFPRGGTGA
                     LIQAMVRLLKDLGGEVRLNSPVERITMANGRATGVVVNGEALAFDMVASNADVVHTYQR
                     LLGQEPRGQKEGAKLASRRHSMSLFVIYFGLKRVHPEVRHHTVLFGPRYRELIAEIFKG
                     PDLPDDFSLYLHAPTRTDPSLAPEGCDAFYVLAPVPHLASADIDWAVEGPRYRDRILAY
                     LEERYIPGLTADLDTCRIFTPVDFRDQLNAHQGSAFSLEPILTQSAWFRVHNRDDQIPN
                     LYFVGAGTHPGAGVPGVVGSAKATAALMIEDARQPA"
     gene            complement(8074..9240)
                     /gene="crtY"
     CDS             complement(8074..9240)
                     /codon_start=1
                     /gene="crtY"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /product="lycopene cyclase"
                     /protein_id="ABC50115.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 3.4e-118,
                     bitscore: 384.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQVDAFDTSAPDLLLVGGGLANGLLALRLSQVRPDLDVRIVEAAQ
                     TLGGVHTWSFFDSDLTQAQRDWIAPLVVHRWPGYSVRFPQFERALSTPYCSVTAERFAA
                     VVEAALPGRIMLGAPVASVSPTEAVLADGRRLSAKAVIDGRGPTATPDLALGFQKFVGL
                     EVRLAAPHGLTTPIVMDACVDQAGGYRFLYTLPFDDRTLLIEDTRYTDGDALDRAAFRQ
                     GVLDYAHAQGWEIETILREEDGVLPVALDGDIGAHLSRMGLTALSGLRAGLFHPTTGYS
                     LPDAVRLADRLAQDFEPATVAEDIRRYAHDVWAGRGFYRLLNRMLFRAARPDERYKVLE
                     RFYRLPQPLVERFYAAGSTLADKARILSGKPPVPIGAALTCLVERGRA"
     gene            9321..10046
                     /gene="crtW"
     CDS             9321..10046
                     /codon_start=1
                     /gene="crtW"
                     /product="beta-carotene ketolase"
                     /protein_id="ABC50116.1"
                     /transl_table=11
                     /translation="MSAVTPMSRVVPNQALIGLTLAGLIAAAWLTLHIYGVYFHRWTIW
                     SVLTVPLIVAGQTWLSVGLFIVAHDAMHGSLAPARPRLNTAIGSLALALYAGFRFTPLK
                     TAHHAHHAAPGTADDPDFHADAPRAFLPWFYGFFRTYFGWRELAVLTVLVAVAVLILGA
                     RMPNLLVFWAAPALLSALQLFTFGTWLPHRHTDDAFPDNHNARTSPFGPVLSLLTCFHF
                     GRHHEHHLTPWKPWWSLFS"
ORIGIN
        1 ctccagcttc agcctgacca accgctatac ctcctcggcc ctgacctcag acctggcctg
       61 gctgttcggc gccggcttcg cgcccctggc ggccctgtgg atctccagcc agttcggcct
      121 gatcgccgcc ggcgcctatc tgctgtcggg cgccatctgc accctcttgg ccctgtggct
      181 gaaccgcgaa ctggcccgca gctcctccga caaggaccgc gccaagacgg cctgatcctt
      241 cggatcattc acaaaaggac acggcccgca gtcgcccgcg ggccgtgttg cgttttgggc
      301 tatcgctggg tcaggtttgc gtcagatcgc cctgcggcga ggcagcgaag gtcgtcaccg
      361 tcttcaagta agagggtttc gcggcgatgg ccgatctagc tgtgaaatct cgctgcctgc
      421 ccatttgtcc cacatctgga agtagaggcc atagttgccg ttgaagcgct tgtggtgcgc
      481 gtcgtggtgg gtggcggtga tcatccagcg tagcggggca cgtttcaacc acgaggcggg
      541 ccagacctct cggccggcgt ggttcaacac ggccgtggcg gtcatcaggg tcagcagcgc
      601 cagcgccacg ccccaatgga tcggtatgaa cagcgtcagg gccggcagga accaggccgt
      661 ggcgatcgcc tcggccggat caaaggcgaa ggaggcgaag gcgctgggat cgcgcgaccg
      721 atgatgctcg gcatgggccc aggggaagat gcgcggatgg tgcagtgcgc ggtgaaccca
      781 atagtagaag gcgtcgtggg ccagcatgta gacgataaag ctgacgggca gccaccacag
      841 cggccatgcg tgggcgtcat cgtagatcgc cgtcccgccg cgcttccaga actcgatgac
      901 gaatgcggcc ggcaaggcgt agatcgggca ggcgatcagg gacgctacga cttcggcgcg
      961 gatgcgtttc gccgccggcg gcctgtggtt cagctgccgc ccccgtcccg ctccgcccca
     1021 cagcaagcta tgagtcacga caccgaccag cagatagcgc acaccgatga tcaggctgag
     1081 cgcgagggtg gtgacgaaca ggtccttcaa catgtgcgca cagacggcga aacgtcgcgc
     1141 cgggtcaagt cgtgacgcgc ggtcctcaaa gcgcctatga tgcggtcatg tcctggccga
     1201 cgatgatcct gctgttcctc gccaccttcc tggggatgga ggtcttcgcc tgggcgatgc
     1261 atcgctatgt catgcacggc ctgctgtgga cctggcaccg cagccatcat gagccgcacg
     1321 acgacgtgct ggaaaggaac gacctgttcg cggtggtgtt cgccgccccg gccatcatcc
     1381 tcgtcgcctt gggtctacat ctgtggcctt ggatgctgcc gatcggcctg ggcgttacgg
     1441 cctatggact ggtttatttc ttctttcacg acgggctggt gcatcgccgg ttcccgacag
     1501 ggatcgcagg gcgctcggcg ttctggacgc gacgcattca ggcccaccgg ctgcatcacg
     1561 cggtgcggac acgcgagggc tgcgtatcgt tcggcttcct ttgggtgcgg tcggcgcgcg
     1621 cgctgaaggc cgaactgtct cagaaacgcg gctcatccag caacggcgcc tgagccagag
     1681 cggccaggtc cgccgagccg gtgcagaaac aggccagtct cagctgagcc gccatcagat
     1741 ccagatgatc aaccacggcc tcagtcccgg tcagcgcggc ttcgagcacg cccgccgcct
     1801 ggccgaccag acaggcgccc agccggatcg cgcgcgctgc atccagcccg tcgcggatgc
     1861 cgcccgaccc gatcaaatcc agttccggcg cggcctgggc gcagtttagc aggctgcgcg
     1921 ccgtcggcac gccccaggca gcgaagggcg cggccagcgc ttccgcccga ccgcccgtgg
     1981 ctcgcgcgcc ttcgatcagg ccccagttgg tgccccccgc cccggccacg tccagcgcgg
     2041 cgacgcccat gtccgccaga cggcgcgcca ccgcgcccga cagcccggcg ccggtctcct
     2101 tgacgatcag acgacccggg aaagccgccg cgacccgttc gatgcctcgc gccacgccgc
     2161 gccaatcgcg atcgccctcg ggctgaacgc cttcctgtaa cgggttcaga tgcaggatca
     2221 gggcgtcggc gccgatcatc tccatggccc gccgcgcctc gtccacgcca tagcccaggg
     2281 cgaactgcac ggcgcccaga ttggccagga tcatcgcatc gggggcgcgg cgtcgcagat
     2341 ccagccccaa acccaaacca ccgtccgttt ccagcgccac gcgctgcgag ccgaccgcca
     2401 gaacgacgcc caaagcctgg gcggcctcgg ccagacgcgc attgatcgcc tcggcccgcg
     2461 acgggccgcc ggtcatcgaa ctgatcagga acggcaaggc gacccgtcgc cccagaaagc
     2521 gcgtcgccag atcgatcgcg tcgtgatcga tgtccggcag ggcgtcatga acaaaacgga
     2581 cggcgtccag acccgaggtc gtctggctga cgcctcgccc ggcccgcacg tggtcgatgt
     2641 gttcgtcctt gcgccggatc aaggcatcgg cgtcggtgga catcgcaaac ggctcctggc
     2701 gggttgcatc cgacgcggtc gtgatgccgt atggcatcat aagggttcgg cgcgtggtcg
     2761 caacgcgacg ccggcgacta tgggagatct gtatggcgat cgtcggcatc cggcgccaaa
     2821 cgcccctggt gggcgcatcc tgcgcccccg acgatctgcg cctgcaggtt caggcgcgcc
     2881 tggccgaggt ggcgccggcg cacgacggcc tgctgtccac agcggctcgc gaggccttgc
     2941 tgggacgggg aaaacgcgtc cggcccgtgc tggccatgct ggcggcggcg catgtcggcg
     3001 gcgatcccga agacgccttg gaatatgcct gcgcgctgga aatggtccat gccgcgtcgc
     3061 tggttctgga cgatctgccg tgcatggacg acgcctcgct gcgtcggggc cagccgaccc
     3121 tgcatcatcg ccacggcgag gatacggcgg ttctggcggc cgtggccctg ttgaaccagg
     3181 cgacgcgtct ggtgctgcag actgcggcgc cggcggaaac gcgtctggcg gccctggacc
     3241 ttttgacgca ggcgatcggc ttcgacggcc tgtccgaggg tcagatgcgc gacctgcgcg
     3301 acgacgcgcg ggatcgcgac gaaagcgccc tgcgtcagat caacgatctg aaaaccggcg
     3361 ccctgtttgt cgccaccgtg cgcggcggcg gtctgctcgg cggcggcgat gcgcaggatt
     3421 tggcgcggct gtcgatcttc ggcgaggcga tcggcttcgc cttccagctt tgcgacgatc
     3481 tgctggatgt ctgttcgacc gtggacgccg ctggcaagga cgtgggtcaa gacgacgaca
     3541 ccaccacctt cgttgatctg tggggcgaat gccggacccg cgcggcggtt cggcaatcgt
     3601 tgggcaaggc ggtcgaggcc gttggccatg acagccccct ggctgtctat gtcctggacc
     3661 ttttccagca ggccgaactt ggggtgtgac gtcgcgccgg ccttgtcgct gagcgggatc
     3721 gatgcgggct acgacggccg acccgtgctg cgtgacttca gtctcagcat cgcggcgggc
     3781 gaagtctatg ccctgctcgg ggcgaacggc gcgggaaagt ccacggtggc gcgtgtcgcc
     3841 tgtggtctgc tgcccgttcg gcgcggtcgt gtcgtcctgg gcgacggcgg cggaccacgc
     3901 gggcgcatcg ggctggcgcc gcaggacagc gccttgttcc cggccctgtc gccacgcgag
     3961 aacgtcgatg tgacggcgcg gctatgcggc gtgcccaagc gtgatcgcgg cgcggcggtc
     4021 aaccgcgcgc tcaacctgac cggctgcggc ccgcgcgcgg accagccggt gcgcacattg
     4081 tccggcggct ggacgcggcg cgccaacctc agcgccgccc tggtcgggca accgcgcctg
     4141 ctgatcgccg acgaaccgac ggaaggggtg gatgcggcga cccgcggcat cctgtcggtc
     4201 gccctgcgcg aaaccgcaaa agccggcgcc ggctgccttc tgatcagtca cgacgccgtc
     4261 ttcgtcgccg atacggccga ccggatcggc gtcctggcgc aggggcgtct gctggcccaa
     4321 ggcgcgccga acgccctgct tcatcacgcc ttcggctcag cccggctgct cagcattcgc
     4381 ctgacccgac aggcgtcaga ccctgccgcc caatggttcg cccaggcggg gctgaccgcg
     4441 tccgaggacg ggctggagtg gcgtcggctc tgcgacgacg ccctggccat cgctcagatg
     4501 ctggccgccg tcgtcgatgg ggaggatggc gagatcgccg tgcgccgccc aggcctggac
     4561 gacctggtcg cgcagctgtc gcaggccccg tcatgatggc ggtggngggc gcctgggcga
     4621 gagggttttg gcgcgaccgc tccggcgtga tcctgaccct gcttttgcca cccctggnct
     4681 atttgctgtt cgnggcgatc ttcggcgcgg gngcgcgcgg cgacatcgac acgaccgtgg
     4741 tgctgcacga cgcgtcgcgc acgcccgcga cgncggcgat ccgcgaggcg gtgtcaaagg
     4801 acatgggcgc gcgtcttcgc atcgtcgaag atcgcgaggc cttcgaccgc gccgtcatcg
     4861 acggtcgcgc cgacgcgggc atactgatcc gtccctcgac gcagggaccg ccaaaactgg
     4921 tgatcgtttc tgccgccggc cgggacgtgg cggcgtcggc gcttcaggcg cggctagagc
     4981 cgatggccgc cgccctgtcg ggtcaaggcg cacgacccgc accgcgcgtt caaaccctgc
     5041 agatcgggcc tcagggtgat gtgcaggcga cctattatgc gggcgcggtc agcgtcatgt
     5101 tcgtcttctt cgccgccatg cacggggcca tgggcgggct ggacgagcgg cgatccggcc
     5161 tccaatcacg cctggccctg gcgcgcggcg gcctcgcgcc catccttgcc ggacgcgccg
     5221 cctggctgac ggcggtgggc atgatgcagt cggcggcagt gttcgtcgcc gcctgcgtca
     5281 agctgcccgc cctggagcct tggcaaatgg cggcggcagc tgtcaccgca ttggcggtcg
     5341 gtttctgcgc cgctggtctc gccctggctc tgacagcagc gtgtcgatcg cgcgaacagg
     5401 cccagccgct gacgaccttc gtcgtcctgc ttctggccgc tctgggcgga tcgatggcgc
     5461 cgcgcttttt gatgccggag gctttccgtg agctcggctg gatcacgccc cacgcctggg
     5521 ccatcgaggc ctatcaggcc gtgatctggc gtggcgaatt cacgtcgacc gtcatcgccg
     5581 cctgggcggt catggccggc ctgggcgtaa gcggtcttgg cgtcgctctg atgttggagc
     5641 ggcggcgcgc ggctcgctga tcgtcagacg tgggtccata acgccgggcg cggcggcggc
     5701 tcgcgccagg cgtccagcgt cttgcaccac agggcgatca gaccaccccg ccccagcagc
     5761 atcagcttgc ccgccttgtc gatcgaggtc cgcccatccc aggcgctcac gccggcgcgc
     5821 gacacatggc ggccgatcga acgatagacg ccgcgcgccg tggcgatggc ccaggccgaa
     5881 cgcgggttca gatcgcgcaa accccagcgc gccgaggcgt agaagggctc ggccgccgcc
     5941 accagacgct gcgccgtccg ggcaacggcg gcgcggtgct ggggctgatc gacctgatcg
     6001 cgcggcacgc ccgcctcatc cagccaggcg ccgggcagat agacgcgtcc gcccttcgca
     6061 tcctcgacca cgtcgcgagc gatgttcgtc agctggaacg ccagccccag gtcctgggcg
     6121 cggcgcaggg tgggcgcgtc ctctaccccc atgatccgcg ccatcatcac cccgacgacg
     6181 ccggcgacgt gataggcgta gtccagcgtg tcctccagcg tatcgtaacg ccggccgacc
     6241 acgtccatct cgaacccctg caacaggtcc atcgcctcat cggctggaat gccatgacgc
     6301 atggccacgc gctggaaggc ggtgaagacc gggtccgtct gcggctcacc ggccaaggcg
     6361 gcggcggtgc gaaggcgcag ttcgtccagc ttctcgccgg ccagcacagg atcgatgccg
     6421 accgcgccgt ggcccagcac ctggccgtcg atctcgtcgt cgcagtgccg gcaccaggaa
     6481 tacagcatcc aggcgtcgtc ccggatcgcc gccggaaaca ggcgcgcggc ggcggcgaag
     6541 ctcttggacc cctgctccat cgactggcgg ctgtgatcca ggaccgcgtc ggtcatgccg
     6601 gctgcctcgc gtcctctatc atcagggcgg cggtggcctt ggccgatccg accacgcctg
     6661 gcacgcccgc gccgggatgg gtgccggcgc ccacaaaata aaggttcggg atctggtcgt
     6721 cgcggttatg cacccggaac caggcgctct gcgtcaggat cggctccagt gagaaggccg
     6781 agccctggtg cgcattcagc tggtcgcgga aatcgaccgg cgtgaagatg cggcaggtat
     6841 ccaggtccgc cgtcaggccg gggatgtaac gttcttcgag ataggccagg atccggtcgc
     6901 gatagcgcgg cccttcgacc gcccagtcga tgtccgccga ggccaggtgt ggcacgggcg
     6961 caagcacata gaaggcgtcg cagccttccg gcgccagtga cggatcggtc cgcgtcggcg
     7021 catgcagata cagcgagaag tcgtcgggca ggtccggccc cttgaagatt tcggcgatca
     7081 gttcgcgata ccgcggcccg aacagcaccg tgtggtggcg cacctccggg tggacccgct
     7141 tcagaccgaa atagatgacg aacagcgaca tggaatggcg gcgcgacgcc agcttggccc
     7201 cctccttctg accgcgcggt tcctgaccca acaggcgctg ataggtgtga accacgtcgg
     7261 cgttggaggc gaccatgtcg aaggccaggg cctcgccgtt caccaccacg ccggtcgcgc
     7321 gaccgttcgc catggtgatg cgctcgaccg ggctgttcag ccgaacttcc ccgcccagat
     7381 ccttgagcag acgcaccatg gcctggatca gggcgccagt gccgccacgc gggaaccaca
     7441 cgccccagcg ccgctccagc gcatggatca gcgcatagat cgacgaggtc gcgaacggat
     7501 tgccgccgac cagcagggag tggaagctga acgcctgacg caggtgctca tcctgaatat
     7561 agctggcgac cttgtcatag accgaccgcc aggcctgaag ccgcatcagc tccggcgccg
     7621 ccttgaccat gctggcgaag tccaggaacg gcacggcgcc cagcttcaga tagccttcct
     7681 tcaacaggtc ctgcgaatag gccaggaact tgcgataacc ttccttgtcg gccggattgc
     7741 gcgccacgat ctggcggtcc agctcgtcct gatcgttgac gtagtcgaag acgtcgccgt
     7801 cttcccagca cagccgatag aagggcgcga ccggcagcag ttcgacatag tccgacagct
     7861 tacgcccgct ggcctcgaac agttcctcca gcgctgacgg gtcggtgatg acggtgggac
     7921 cggcgtcgaa ggtatagccc ttgtccttga agacgtaagc ccggccgccc tccagatcgc
     7981 gggcctcgaa caccgtggtc tgaatgcccg ccgactgcag ccgtatggcc agcgacaagc
     8041 ctccgaagcc cgatccgatt acagcagccc gcatcacgca cgtcctcttt cgaccagaca
     8101 ggtcagtgcg gcgccgatcg gcaccggggg ttttccactc aggattcgcg ccttgtcggc
     8161 gagggtcgat ccggcggcgt agaagcgttc gaccaaaggc tggggcagac gatagaaccg
     8221 ctccagcacc ttgtatcgct catcgggccg cgccgcacgg aatagcatcc ggttcagcaa
     8281 ccgataaaag cctcgtccgg cccatacgtc atgcgcatac cggcggatgt cttcggcgac
     8341 cgtcgccggc tcgaaatcct gcgccaatcg gtcggccagg cgcaccgcgt caggcaggga
     8401 atagccggtg gtcgggtgaa acagcccggc gcgcaggccg ctgagcgccg tcagccccat
     8461 ccgcgacaaa tgcgcgccga tgtccccgtc aagcgccacg ggcaggacgc cgtcctcttc
     8521 gcgcaagatc gtctcgatct cccagccctg cgcgtgggcg taatccagca cgccttgccg
     8581 gaacgccgcg cgatccagcg catcgccgtc ggtgtagcgc gtatcctcga tcagcagcgt
     8641 gcgatcatcg aacggcaggg tgtagagaaa ccgatagccc ccggcctgat cgacgcaggc
     8701 gtccatgacg atgggcgtgg tcagaccgtg cggcgccgcc agccgcacct ctagcccgac
     8761 gaacttctgg aaacccagcg ccagatccgg cgtcgcggtt ggcccgcgcc catcgatcac
     8821 cgccttggcg ctcagacgcc gtccatcagc cagcaccgct tcggtcggcg acaccgaagc
     8881 gaccggcgca cccagcatga tccttccggg caaggccgcc tcgaccaccg ccgcaaaccg
     8941 ttcggccgtg acgctgcaat agggggtcga cagcgcccgt tcgaactggg gaaaacggac
     9001 gctgtatccc ggccagcgat gcaccaccaa gggcgcgatc cagtcgcgct gcgcctgcgt
     9061 caggtcgctg tcgaagaagg accaggtgtg gaccccgccc agggtctgcg ccgcctcgac
     9121 gattcgcacg tccagatcag ggcggacctg cgacagccgc aacgccagca aaccattggc
     9181 caggccgccg ccgaccagca aaaggtccgg cgcggaagtg tcaaaggcgt cgacctgcat
     9241 tccagacagg tggcacgcga cgacgcatgc ggcaagcgaa caggatgctt accgggccgc
     9301 gatgcgctaa gtgtcgcgcc atgtccgccg tcacgccaat gtcacgggtc gtcccgaacc
     9361 aggccctgat cggcctgacg ctggctggcc tgatcgccgc ggcctggctg accctgcaca
     9421 tctacggcgt ctattttcat cgctggacga tctggagcgt cctgaccgtt ccgctgatcg
     9481 tcgccggcca gacctggcta tccgtcggcc tgttcatcgt cgcccacgac gccatgcacg
     9541 gctcgctggc cccggcacgc ccacggctga acacggcgat cggcagcctg gcgctggccc
     9601 tctacgccgg atttcggttc acgcctttga agaccgcaca ccacgcccat cacgctgcgc
     9661 ccggtacggc ggacgatccc gactttcacg ccgacgcccc gcgcgctttc ctgccctggt
     9721 tctacggctt tttccgcacc tatttcggct ggcgagaact ggccgttctg acggtgctcg
     9781 tggccgttgc ggtgctgatc ctcggcgccc gtatgcccaa tcttctggtc ttttgggccg
     9841 cgcccgccct gctctcggcg ctacagcttt tcacattcgg cacctggctg cctcataggc
     9901 acaccgacga cgccttcccc gacaaccaca acgcccgcac cagccccttc ggcccggtcc
     9961 tgtcgttgct cacctgcttc cacttcggcc gccaccacga acaccacctg accccctgga
    10021 agccctggtg gagtttgttc agctaggcgt ccccggcggt cgttttcaat ggcaacataa
    10081 cgcacgaagc ctctgccccg ccgcaccgtg ggcgtctgct gatcggccta tattctgaga
    10141 ggaatggcgg agacggaggg attcgaaccc tcggtacccc ttacggggta cgacgat
//
