LOCUS       BGC0000645              7475 bp    DNA     linear   BCT 27-JAN-2009
DEFINITION  Halobacillus halophilus strain DSM 2266 carotenoid biosynthesis gene
            cluster, complete sequence.
ACCESSION   BGC0000645
VERSION     BGC0000645
KEYWORDS    .
SOURCE      Halobacillus halophilus DSM 2266
  ORGANISM  Halobacillus halophilus DSM 2266
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Halobacillus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 13:58:45
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..1485
                     /gene="crtNa"
     CDS             1..1485
                     /EC_number="1.14.99.-"
                     /codon_start=1
                     /gene="crtNa"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 410.9; E-value: 1.5e-124)"
                     /gene_kind="biosynthetic-additional"
                     /note="diapophytoene dehydrogenase"
                     /product="CrtNa"
                     /protein_id="ACM07424.1"
                     /sec_met_domain="DAO (E-value: 2.3e-13, bitscore: 39.0,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVAVIGAGPGGLASAMILASKGYDVHVFEKQPFVGGRNGHFSL
                     GDYTFDIGPTFLSMPHIVEELFEMSGRNAHDYMDLIELAPMYELQFDGKRVPMYRDRMK
                     MLNVISKHFPGNEKGYVRFMNDTRKKMDALLPLLQTRHNKLTDYVSLRALKALPKLSLG
                     KSVYQVLSEYFTDEKLKIAFTFQAKYLGMSPWECPGAFSILSYMEHEYGVFHPKGGVNQ
                     LSKSMAKVTEEHGGQIHLGNGVRKFKTEGKKVVGIELESGEEFEADEVIVNADFANAMS
                     HMVEGNELKKYSEKNLAKKKYSCSTFMIYVGLDKLYEQMPHHTILFAEDYKKNVDEMTK
                     DLVLSDEPSIYIHNASVTDDTLAPEGHSAVYILAPVPNNYSEIDWDEKQETFKNLILDE
                     LESKTGFHDIRDHIVTEKVLTPKQWQTDHFVHKGATFSLGHQLSQMMYFRPHNRFQELD
                     HCWLVGGGTHPGSGLPTILESARITTGWIREEAETS"
     source          1..7475
                     /db_xref="taxon:866895"
                     /mol_type="genomic DNA"
                     /organism="Halobacillus halophilus DSM 2266"
                     /strain="DSM 2266"
                     /type_material="type strain of Halobacillus halophilus"
     misc_feature    1..7475
                     /note="carotenoid biosynthesis gene cluster"
     protocluster    1..7475
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[2965:3802]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2966..3802
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..7475
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..7475
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000645"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..7475
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1482..2963
                     /gene="crtNc"
     CDS             1482..2963
                     /EC_number="1.14.99.-"
                     /codon_start=1
                     /gene="crtNc"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 320.2; E-value: 4.9e-97)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative diapophytoene dehydrogenase"
                     /product="CrtNc"
                     /protein_id="ACM07425.1"
                     /transl_table=11
                     /translation="MKQTQTAIVGGGIGGLVTALLLSKDKDRKITIFEKNDYLGGRLTY
                     ERNGPYKIDQGPTIVLLPEMLLTILEEGGFERKDIPLIACDPLYDIRFKDGSAFTKYSD
                     PDQQKQELKAKFPGSEKQFDRFLIDMKIRFLRGKSQFLEQSFVNKRRFFSGQNIKTLIQ
                     LKAYQNVKKMMRSYFADEQLVEAYTLQTLYIGGHPEQSPAMYSLVSYSEHEHGIWYMKG
                     GYAHLVDLIVERLKERGVEIHTGAEVKQLHTSHSKVKSITAGDKEVEVDELILNGDFPT
                     MDRLLPEERQHKRNYTPSSGCLLLYMGLDKIYPNHTIHQFFMSSNFDEHMKQVFDTKEL
                     PDDPSFYTFHPSIVDDSLAPAGKGVLYTLIPVPAGDDVDWSKKDQLIDHVLQQMEERGF
                     PELRKHMNWMKVRTPEEAKRDGLYGGGSFGIAPTLFQSGVFRPQLKPYSLSNLYAVGAS
                     IHPGGGIPIVMQGAKLLADHLQNGSEERHNYKRGV"
     gene            2966..3802
                     /gene="crtM"
     CDS             2966..3802
                     /codon_start=1
                     /gene="crtM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /note="diapophytoene synthase"
                     /product="CrtM"
                     /protein_id="ACM07426.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.3e-70, bitscore:
                     226.3, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMDLNNAYDHCKNIIEKHSKTFSKAFAMLPKHQKRAVWAIYAFCR
                     RADDIVDEGENPKEELEAFAVEFDLFMEGRLETEDPCWIALQDAFERFPLDPAPFYEMI
                     VGQRMDLYPKTIDTKDDLLHYCYHVASTVGLMLLPVLAPGKVSRVKTGAIELGYAMQIT
                     NILRDIGEDLDNHRIYIPKQMMIEYGYTRTDLHNKKVNEAFIQLWEDLAQDAEHYYRNA
                     LATLPEYPVYSRTPVGGAAKMYRAIIQTVRNNDYQVFGKRNYVSDQMKKQIIAEMQ"
     gene            complement(4231..5808)
                     /gene="crtNb"
     CDS             complement(4231..5808)
                     /codon_start=1
                     /gene="crtNb"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 369; E-value: 7.6e-112)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative diaponeurosporene oxidase"
                     /product="CrtNb"
                     /protein_id="ACM07427.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.7e-10, bitscore:
                     29.2, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 2.7e-12, bitscore: 35.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVLFHPRVYRFAYFNYDFLDDGTYQGKILSVERKVLRMKVAIVG
                     GGLGGLSAAVTLAKAGAEVNLFEKNDHFGGKMMPVNEAGYHFDFGPNTITMPEAFQDVL
                     RQGGLEKELSFTKLTHHTRNQFKDGTIFDLSSDRQYMKQQLYRLDQKGFQNYDAFLLEI
                     ERLFHLSKEYFLHRTFSGWKDYLSPSLAKGFAQVRPLESMDHFFRRYFSHPGIIQSLNR
                     YSTYVGSNPYVTPATFAMIAHLELNDGVYYVPGGNTKIAENMANAAENQGAQLYKNTRV
                     EKILTHNKQATGVMAGGHTYEADYVIVNGDLLQSVPELIDNEKRASLSDKKIRSFDPSI
                     SAFVIMAGLDTTMPDLHHHHVLFSRNYEKEFSSLKNGQYPEEPTIYIGTSAKSDSTLSS
                     EGDNCFILVNAPALGTSTEIDRERYKEKIYEDLAHSGLPIKNHVSFEKVIGPEEIESRF
                     GAYRGSLYGPSSNRRLQAFMRPFNQSQDFSNLYFCGGSTHPGGGSPMVVLSGQNVANQI
                     LGKIVHPE"
     CDS             complement(5691..6800)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf-GT"
                     /product="putative glycosyl transferase family 2 protein"
                     /protein_id="ACM07428.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 4.7e-25,
                     bitscore: 77.1, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFFTIVLMITVLLNLWTILNSFFLLPLTSAKNLKNEPRVSLLIP
                     LRNEEENVEGLMNSINNLSYPSLEVIFLDDHSEDKTYEKLLHETKNDPHLKVHQGKELP
                     DGWNGKVHACYQLSKLASGDYYLFLDADARVAPSIIEKTLATMEKHGASMLSGFPHYPN
                     DHFLSHMLVPLQHMVVQLHLPLAVANFTKQPMFTAACGIFIMVERNAYEAIGGHESVKG
                     SLVEDVHISREMKKHGYKMVLANITPSVLSYMYHHPKETWAGFQKNIYTGLGRSAALVV
                     ILSLLYTLLFLVPFGFIAVAFVEGSWLYVLPYLLTVSFKMYVDARTGHPLWLSFFIPVS
                     IVLLILIMISSMTVHIRGKSYQWKGRSYE"
     CDS             complement(6819..7475)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141:acyltransferase (Score: 77.7; E-value: 1.4e-23)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf-AT"
                     /product="putative phospholipid/glycerol acyltransferase"
                     /protein_id="ACM07429.1"
                     /transl_table=11
                     /translation="MLKAKKNSFIEWGFSKFNRFLLKSQFKHINVSYSTLPDGPALFLI
                     NHSTWWDPLMIYHLNKEIIRSDGYGMMHEDGIRRFPFFRRIGAFSINTNDRRHLLRSLN
                     YSKALLEQGSTVWIFPQGEEQHLEKRPLEFFTGVAYIAKKCPTVPVVPISIYYSFEHTK
                     KPNVYIKIGEPLDREVYASLNRKEMTRYFEERSTEQLDQLRETIIQEDHQSFRTM"
ORIGIN
        1 atgaagaaag tggcagtgat aggagcagga cctggaggat tagcttcggc tatgatcctc
       61 gcttcaaaag gttacgatgt tcatgtattt gagaaacaac cgttcgtcgg aggaagaaat
      121 ggtcattttt ctttaggtga ctatacattc gatataggtc cgaccttttt gagtatgcct
      181 catatcgttg aggaattatt tgaaatgtcc ggcagaaatg ctcatgacta tatggattta
      241 atcgaacttg caccgatgta tgagttgcaa ttcgatggga agcgggtgcc gatgtaccgt
      301 gatcgcatga aaatgctgaa cgtgatctcc aagcatttcc caggaaacga aaaaggctac
      361 gtccgcttta tgaacgatac gagaaagaaa atggatgccc tgcttccatt gcttcagacg
      421 cgccataaca agctgaccga ttatgtaagt cttcgggctt tgaaagcact tcctaagcta
      481 tcgctcggaa agtcggtcta tcaagtatta tccgaatact ttacagatga aaaattaaaa
      541 atcgctttta catttcaggc caagtatcta ggcatgtcac catgggaatg tccgggagcc
      601 ttttcgattc tttcttatat ggaacatgag tatggagtct ttcatccgaa aggcggagtc
      661 aaccagcttt ccaagtcgat ggcaaaagtg accgaggaac atggaggaca gattcacctg
      721 gggaacggcg tccgcaaatt taaaacagag ggtaaaaaag tcgttgggat tgaacttgaa
      781 tccggagaag aatttgaagc agacgaggtc atcgtaaatg ctgatttcgc gaatgccatg
      841 agtcatatgg tggaggggaa tgagctgaag aaatactctg agaaaaatct ggctaagaaa
      901 aaatattcct gctccacgtt tatgatctat gttggattgg ataaacttta tgaacagatg
      961 cctcaccaca cgattctctt cgcggaagat tataagaaaa atgtcgatga aatgacgaaa
     1021 gatcttgttc tatccgacga accgtcgatt tatattcata acgcaagtgt gacagacgat
     1081 acattagcgc cagagggtca ttcggctgtt tacatcttag cccctgtccc gaacaattac
     1141 tctgaaatcg actgggatga aaagcaggaa acgtttaaaa atcttatcct tgatgagctt
     1201 gaaagtaaaa ctgggttcca tgacattcgt gatcatattg tgacagaaaa agtgttaacg
     1261 cctaaacagt ggcagacgga tcactttgtt cacaaaggtg ctacgttcag cctgggccat
     1321 cagctttctc aaatgatgta tttccggccc cacaaccgct ttcaggaatt agaccactgc
     1381 tggcttgtcg gcgggggcac acatccgggg agcgggctgc ccaccatcct tgaatcagcc
     1441 agaataacaa cagggtggat cagagaggag gcggaaacct catgaagcaa acccaaacgg
     1501 ctattgtagg gggcggaatt ggcggcttag taacagcact gcttctttcc aaagataagg
     1561 ataggaaaat taccatcttt gaaaagaacg attatcttgg tgggcgtctg acctatgaaa
     1621 gaaatgggcc ttacaaaatt gaccaggggc cgaccatcgt tctgctgccg gaaatgcttc
     1681 tcactatatt ggaagaaggc ggttttgaac gaaaagatat tccgctcatt gcctgtgatc
     1741 cgctttatga tatccggttt aaagatggga gtgcatttac taaatattcg gatcctgatc
     1801 agcaaaagca ggaattgaaa gccaaattcc ctggaagtga gaagcaattt gaccggtttc
     1861 ttatagatat gaaaattcgt tttctgcgag ggaaatctca atttttagag cagtcctttg
     1921 taaacaaacg ccgtttcttc tccgggcaga atatcaaaac gttgattcag ctgaaagctt
     1981 atcaaaatgt taagaagatg atgagaagct attttgcaga cgagcagctg gtggaagctt
     2041 atacattgca gactctttat attggcggcc acccggagca gtctccggca atgtattcgc
     2101 tggtatcata cagcgaacat gaacacggga tctggtatat gaaaggcgga tatgctcacc
     2161 tggtcgattt gattgtcgag cgtctcaaag aacgaggggt agagattcac accggtgccg
     2221 aagtcaaaca gcttcacaca tcgcactcta aggtgaagtc tattacagct ggagataaag
     2281 aggtcgaggt agatgaactt atattgaatg gggattttcc taccatggat cgattactac
     2341 ctgaggaacg gcagcacaaa cggaattata caccttcatc cggctgcctg cttctataca
     2401 tgggactgga taagatctat ccgaatcaca cgatccatca atttttcatg tcttcaaact
     2461 ttgacgagca tatgaagcag gtatttgata cgaaagagct gcctgatgat ccttcttttt
     2521 acacatttca tccctcgatc gttgatgatt cattagcgcc tgctggtaaa ggggttcttt
     2581 ataccttaat acctgtgccc gcgggagacg acgtggactg gagtaaaaag gatcaattaa
     2641 ttgaccacgt gcttcagcag atggaggaaa gaggttttcc ggaattaagg aaacatatga
     2701 actggatgaa ggtgaggaca ccggaagaag ccaaaagaga cggtctttat ggaggtggaa
     2761 gcttcggtat tgccccaacc ctctttcagt caggcgtctt ccgccctcag ctaaagccgt
     2821 attctctttc gaatctatac gcggttggag cctcgattca ccctggagga ggcatcccca
     2881 tagtcatgca gggagctaag ctgctagcgg atcatttgca aaatggttct gaagaaaggc
     2941 ataattataa gcgaggtgtt tagagatgat ggacttgaat aatgcttatg accattgcaa
     3001 aaacataata gagaaacatt ccaagacttt ctcgaaagct ttcgccatgc tccctaaaca
     3061 tcagaagagg gctgtatggg ccatttatgc cttttgtcga agggccgatg acattgtgga
     3121 tgaaggggaa aatccgaaag aagagctgga agcatttgct gtagagtttg atctttttat
     3181 ggagggcagg cttgaaacgg aagacccatg ctggattgct ctccaggatg cttttgaacg
     3241 ttttcctctt gatccggcgc ctttttatga gatgattgtc ggtcagcgca tggacttata
     3301 tccgaaaacg attgatacaa aagacgatct ccttcattat tgctatcatg tcgcaagtac
     3361 ggttgggctt atgcttttac ctgtgcttgc ccccggtaaa gtctccagag ttaaaacagg
     3421 tgccattgaa cttgggtatg cgatgcagat caccaatatc ctgagggata tcggagaaga
     3481 tctggataat catcgcattt atatccctaa acagatgatg atcgaatatg gttatactcg
     3541 tacagacctt cataacaaga aggtaaatga agcatttata cagctctggg aagacttagc
     3601 ccaggatgct gagcactact atcgtaatgc attagctact ctgccggagt accccgttta
     3661 ttcaagaact cctgtaggag gagctgcgaa aatgtaccgg gccatcatcc aaacagtgag
     3721 aaataacgat tatcaggtct ttgggaagcg aaactacgta tctgatcaaa tgaaaaagca
     3781 gattattgcg gaaatgcaat aatttgcttt ttttctggct ctattaaact tccgtgagga
     3841 taattacgtt aagctcccgt ttgtgtaaga ctcagtttcg agatattggt tatgaggaag
     3901 atcctcctgg ggacgatttc gctttccggc cctgcacgat gcagggtcga tcgaccctac
     3961 gtcgtgtagg gccaaatgtg gaatcacccc gaaagacacg accagcataa gccgagcatc
     4021 aaaaggatgg tggtttttcc gtccgttgat gaacggctta tgtctcgagt gtctgggtga
     4081 tggaacaaga cgagttattt ccccaccagc cacctcctca tcttgtaacg gacccaattc
     4141 atcttgaaac tgactcttac agataacggc cctattgcgt aataagcctc ttatgaaaaa
     4201 tcaataataa tttttatcag aacctttttc ctattcggga tgaacaattt tgccaaggat
     4261 ctggttggct acgttttggc cgctgagaac gaccattgga gagccgcctc ccgggtgggt
     4321 actgcctcca cagaagtaca gattgctgaa atcctgagac tgattgaatg gtctcataaa
     4381 cgcctggagc cggcggttgg aagagggacc gtaaagggaa ccacgatatg caccgaagcg
     4441 gctttcaatt tcctcagggc cgatcacttt ttcgaaagat acgtggtttt taatcgggag
     4501 tccggagtgc gctaaatcct cataaatctt ctctttatac ctttcccgat ctatttcagt
     4561 tgaagtgcca agcgccgggg cgttaaccag gatgaaacaa ttgtctcctt cagaggaaag
     4621 agtcgagtcc gacttagcag acgttccgat atagatggta ggctcttcag gatattggcc
     4681 attttttaaa cttgaaaatt ccttttcata attcctggaa aaaagaacgt ggtggtgatg
     4741 taggtccggc atagtagtgt ccagcccagc cataataacg aaagcggata tagaaggatc
     4801 gaaggaacgg atctttttat cagataatga ggcgcgcttt tcgttatcga ttaattctgg
     4861 aacggattgt aataggtctc cattcacgat cacatagtct gcttcgtaag tatggcctcc
     4921 agccatcacg ccagtggcct gtttgttatg ggttaagatt ttttctactc gtgtgttctt
     4981 atatagctga gctccctggt tttctgcagc gttcgccatg ttttctgcga tcttcgtatt
     5041 tccgccaggg acgtagtaaa ctccgtcatt taattccagg tgagcaatca tggcaaatgt
     5101 agccggtgta acgtagggat tcgagcctac ataggtagaa taacggttaa gagattgaat
     5161 gatgccgggg tgagaaaaat atcttctgaa aaaatgatcc attgactcaa gcggcctcac
     5221 ctgggcaaac cctttcgcca gggaaggaga gaggtaatcc ttccacccgg aaaaggtccg
     5281 atgaagaaaa tattcttttg ataaatgaaa caggcgttca atttccagta aaaaggcgtc
     5341 atagttctga aagccttttt gatccagacg gtagagctgc tgcttcatat actgccggtc
     5401 tgaggacaga tcaaagattg tgccatcctt aaactggttt cttgtatgat gagtaagttt
     5461 agtaaaggag agttcttttt ctaaacctcc ctgccgaagg acatcttgaa atgcctctgg
     5521 catggtgatg gtattcggcc cgaaatcgaa atgatagcct gcttcattga caggcatcat
     5581 cttcccgcca aaatgatcgt tcttttcgaa aaggttaact tcagctccgg ctttggccag
     5641 ggtgacagcc gccgaaagcc cacctaagcc gccgccgact atagcaactt tcattcgtaa
     5701 gaccttcctt tccactgata ggattttccc ctgatatgta ccgtcatcga ggaaatcata
     5761 attaaaataa gcaaaacgat agacacgggg atgaaaaagg acagccataa tggatgacct
     5821 gtgcgagcat cgacatacat tttaaaggat acggttaata agtaggggag cacatacagc
     5881 cagctacctt ctacaaaagc cacagcgata aatccgaatg gtacaagaaa taagagagta
     5941 taaagcagcg ataagataac caccagcgct gctgatcgtc ctaatccggt atagatgttt
     6001 ttctggaaac cggcccacgt ttctttagga tgatggtaca tataggaaag gacggaaggt
     6061 gtaatattgg caagcaccat tttatagccg tgctttttca tctccctgct gatgtgcacg
     6121 tcctctacga gtgatccttt aacggactcg tgtccgccga tcgcttcata ggcgtttcgt
     6181 tccaccataa taaaaatccc acacgccgct gtgaacatcg gttgtttcgt gaaattagcc
     6241 acagcaagag gcagatgaag ctgcacgacc atgtgctgaa gcggtaccag catatgactt
     6301 aggaaatggt cgtttgggta atgagggaag ccacttagca ttgaagctcc gtgtttttcc
     6361 atcgtggcaa gggtcttttc gatgattgaa ggtgcaacgc gcgcgtcggc atccagaaat
     6421 aagtagtagt ccccgcttgc taacttggag agctgataac aggcatgaac ttttccattc
     6481 cagccatccg gcagttcttt cccttgatgc acctttaaat gtggatcatt tttcgtttca
     6541 tgtaagagct tctcgtacgt cttatcttcc gaatggtcat ccagaaaaat cacctcaagc
     6601 gaagggtagc tcaagttatt aatggagttc atcagcccct ccacgttttc ctcttcgttt
     6661 cttagaggaa tgagaaggga gacacggggc tcgtttttta aatttttagc tgaagttaaa
     6721 ggcagtaaga aaaagctgtt taggatcgtc cacagattga gaagaaccgt tatcatcagg
     6781 acaatggtaa aaaaggtcat ggtctctctt cctttctgct acatggttct aaacgattga
     6841 tggtcttcct gtataatcgt ttcacgcagc tgatccagtt gttcggtgga tcgttcttca
     6901 aaataacgcg tcatttcttt tctgtttaaa gaagcataca cttctcgatc cagtggctcc
     6961 ccaatcttaa tgtagacgtt tggtttttta gtatgttcaa acgaatagta aatggaaatc
     7021 ggaacgacag ggacggtggg acacttctta gctatgtagg cgacccctgt gaaaaactca
     7081 agcgggcgct tctccaaatg ctgctcctct ccttgaggga aaatccatac cgtgctgcct
     7141 tgctcaagca gcgctttact gtaattcaac gatcgaagca gatgtctccg atcgttggtg
     7201 ttaatggaaa aagcaccaat cctgcggaaa aaaggaaagc gcctgatccc gtcttcatgc
     7261 atcattccat aaccatcgga ccgaatgatc tctttattca aatgataaat catcaatggg
     7321 tcccaccatg tagaatgatt aattaaaaat agggcaggcc cgtcaggcag ggtagaatag
     7381 gatacattaa tgtgcttaaa ttgtgacttc aatagaaagc ggttaaactt ggaaaatccc
     7441 cattcaatga atgaattctt tttagctttc agcat
//
