LOCUS       BGC0000653             21694 bp    DNA     linear   BCT 25-JUL-2016
DEFINITION  Streptomyces arenae strain TU469 pentalenolactone biosynthetic gene
            cluster, complete sequence.
ACCESSION   BGC0000653
VERSION     BGC0000653
KEYWORDS    .
SOURCE      Streptomyces arenae
  ORGANISM  Streptomyces arenae
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 13:59:22
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 21694
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(<1..2707)
                     /codon_start=1
                     /note="Orf-1"
                     /product="putative WD-repeat containing protein"
                     /protein_id="ADO85568.1"
                     /transl_table=11
                     /translation="MSAEETEPLLAAAVVRVTGDRRDEDPSGGGGGGGAGFFVTPELIL
                     TCAHVVSDALDLPPEATVEPGARVTVRLLLANNGDGVAAAPMAPAEVVDWVPLGEDRTG
                     DVALLRVSRPLPGARPLPMADAKSVRNHRSWVVGFTQAHPHGLWHRGRLLGITGGGWIQ
                     LARMDGEDAHVEGGFSGSPVWDEDLDAVVGMMVAAEPVRAAQQAFALHTRVIVENLREL
                     EAVADPPSPFRGLAPFEEKDSEVFFGRAAEIGKAVDAVRGHPVVTVYGPSGCGKSSLVL
                     AGVVPKMRRDAYDVLVLGAGHAGSLRVALATELYEAARAGDDGPPRATDVDQVDRWLAE
                     LGLVDAYHRATGRPARRLLLVLDQAEALLNRPEQEIAETIALIFFPQRPPTGLRVLVTL
                     RADFMDAALRHPHLGPALQSGETLPLTPMTPDQLRDVITEPLRRIPAVGYDPGLDQRIV
                     DDAGGEPGVLPLLGFVLQELWDKRSGGRLRTQTYHDIGRVTGALSRHAESVWKECVTSG
                     TQDDAGRLLTGLVKVLPGGGAPLRRALTRQEAGEDRWRLAQALAERRLLVLYGGDGRPE
                     SAELAHEALITAWPTLADVTRADAAFLTARAELRHDLERARQENGPGPAVLPMGAQHLA
                     GREAELDAAEREFLTSVRRRVRARRRLRGTALVAAALALTLIASLLTYLMQQSQVSTER
                     QAEGRSRALAVRSDELTDSDPGTAALAAVAAYEVAPTQEARSALMRRYQEQRRTAWLLS
                     GAEGELNAAAMSADGRVTLVTSETGRATLFVRGADGRVRTRQLNLAENVLVPAVSRDGR
                     RIAYVRDGDGVVVWRDVTPGAKELVGRAHELEGAFSHISLAASSGMDDLKILDFSPDAR
                     RLVATPAGDSGLPAQVWDLATGQPHSLPRRI"
     source          1..21694
                     /culture_collection="DSM:40734"
                     /db_xref="taxon:29301"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces arenae"
                     /strain="Tu469"
     subregion       1..21694
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="terpene"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..21694
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(2888..3349)
                     /gene="pntR"
     CDS             complement(2888..3349)
                     /codon_start=1
                     /gene="pntR"
                     /gene_functions="regulatory (smcogs) SMCOG1135:MarR family
                     transcriptional regulator (Score: 98.6; E-value: 3.7e-30)"
                     /gene_kind="regulatory"
                     /note="MarR family transcriptional regulator"
                     /product="PntR"
                     /protein_id="ADO85569.1"
                     /transl_table=11
                     /translation="MTPTQRADQNTDLDVGDLTRAIENFNRYYIRLPAVQKLSFTTLSV
                     LDTLALSGPKRLTELARTEQISQPGLTQLVTRLERDDLVRRHPDPADGRAVLVHITDSG
                     RKIGQSRREDRGRHLIPLIAQLTPAERQAIAAALPALTRLAELGAEAAR"
     misc_feature    2888..15655
                     /note="pentalenolactone biosynthetic gene cluster"
     gene            3490..4494
                     /gene="gapR"
     CDS             3490..4494
                     /EC_number="1.2.1.12"
                     /codon_start=1
                     /gene="gapR"
                     /note="glyceraldehyde-3-phosphate dehydrogenase;
                     pentalenolactone resistance; identical to Streptomyces
                     arenae pentalenolactone-insensitive
                     glyceraldehyde-3-phosphate dehydrogenase (gapR) in INSD
                     Accession U44856"
                     /product="GapR"
                     /protein_id="ADO85570.1"
                     /transl_table=11
                     /translation="MTVRIGINGFGRIGRNVFRAAAARSSELEIVAVNDLGDVPTMAHL
                     LAYDSILGRFPEEVTAEPGAIRVGDRTIKVLAERDPGALPWGDLGVDIVIESTGIFTDA
                     AKARSHVDGGAKKVIIAAPASGEDFTVVLGVNDGDYDPERHTIISNASCTTNCLGVLAK
                     VLHDAVGIDSGMMTTVHAYTQDQNLQDAPHKDLRRARAAALNIVPTSSGAAKAIGLVLP
                     ELAGRLDAFALRVPVPTGSVTDLTVTTRRGTSVEEVKEAYAAAASGPYKGLLSYVDAPL
                     VSTDIVGDPASCVFDAGLTRVSGPQVKVVGWYDNEWGYSNRLIDLATLIGSSL"
     gene            4673..5869
                     /gene="pntM"
     CDS             4673..5869
                     /codon_start=1
                     /gene="pntM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 353.9; E-value:
                     1.8e-107)"
                     /gene_kind="biosynthetic-additional"
                     /note="cytochrome P450 monooxygenase"
                     /product="PntM"
                     /protein_id="ADO85571.1"
                     /sec_met_domain="p450 (E-value: 1.3e-17, bitscore: 53.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDLPRLPFDNPDIMGIAPQMLALQKEGPIARVGTAGEDAWLVTR
                     YDEVRTLLADRRLRLSNPNPQPSAKSAARAFMVALMAGDDHETEPARHAQMRSLLIPRF
                     STRRLRLMKTRIEHHVDELLDQLAASAPPVDLHRVLSFRLPTMVVCDLLGVPLADRERF
                     GQWARGTFDQSDNEHSANTFQQVVDYMLELVARKRVEPGDDILSELIAEKDGALSDADI
                     AHLGNAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAEDPGLAPAAVEEILRLGVGGKG
                     SNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDGGLFDLTRVRPRSHLAF
                     GHGARHCIGRTLARIELTAVFERLFRRLPDLRLAVPEESLRWQEHRITGGFDEIPVTF"
     gene            6009..6860
                     /gene="pntH"
     CDS             6009..6860
                     /codon_start=1
                     /gene="pntH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /note="1-deoxypentalenic acid-11-beta-hydroxylase"
                     /product="PntH"
                     /protein_id="ADO85572.1"
                     /sec_met_domain="PhyH (E-value: 2.5e-20, bitscore: 63.8,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTFSDYADCTPLLDDREALDRFYDEHGYVYLRGVLDRELVRTT
                     AEQMLQGLIALGHAAPGTTLDTLTIESYEAVDEVAMHDHVRYDDLWNHPSTLKVWEKVF
                     GEPVFVFKSTTIRYYPSAPDSAEPSFLTPLHQDGFYIGPNKDFRTAWIPLLPTTRGTGG
                     VAIADGSHKKGPREHVLTENFRRFGHAVRGIPPAEFGADEELLFSPMEPGDVLLFHAFM
                     CHKSLPNVSVDPAGMRMSMDTRIQPASSHRGFNALTPWPESAKDASKGIMSKITGTPTT
                     AE"
     gene            6918..8372
                     /gene="pntG"
     CDS             6918..8372
                     /codon_start=1
                     /gene="pntG"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 296.1; E-value:
                     5.7e-90)"
                     /gene_kind="transport"
                     /note="transmembrane efflux protein"
                     /product="PntG"
                     /protein_id="ADO85573.1"
                     /transl_table=11
                     /translation="MTKREGLPPLTGPSAAQQSRVGTAPAAAGLTGIALMVVLTGYALS
                     IVDASIVNVALSSISDDLNGGAAALELVVSGYGLTYAVGLVLGGRLGDAFGRRRLYAWG
                     LAAFTVTSALCGLAPTIEFLVAARLLQGAAAAMLVPQVLATIQAVTAGQARARAIGMYG
                     ATAALGMVVGQILGGLLVSLDVAGMGWRSVFAINVPIGVAALLLVRRVPATRADARPGF
                     DPVGTVLFGVTMVCLLAVIVAGPDLGWPLWLWSLLVVAAATALALVRAERALEARGGSP
                     LLSPSVLSHPGMRRGLAAMVPFSAGFGAFLFVYALVAQGHFGLDGLASGGVLVPFAAAF
                     FVVTLFTPRIAAALGGRIVTLGALVQCAGLLLLALVIGLGWPHPSLALVLAGIGCYGVG
                     AALTGPTLFRMILADVPAAQAGMGSGVLVTSQQMATALGATVGGTLYVSLSGWLSTVTA
                     AVLVVVLLACFAVTVLLISLKLPDPR"
     gene            8473..9321
                     /gene="pntF"
     CDS             8473..9321
                     /NRPS_PKS="Domain: PKS_KR (8-174). E-value: 4.8e-12. Score:
                     38.0. Matches aSDomain: nrpspksdomains_pntF_PKS_KR.1"
                     /codon_start=1
                     /gene="pntF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     176.3; E-value: 1.3e-53)"
                     /gene_kind="biosynthetic-additional"
                     /note="1-deoxy-11-beta-hydroxypentalenic acid
                     dehydrogenase"
                     /product="PntF"
                     /protein_id="ADO85574.1"
                     /sec_met_domain="adh_short (E-value: 5.6e-32, bitscore:
                     101.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHSQTRAAVVTGAASGIGLALSARFARAGAGVVMADVEGGALHRR
                     AAELIAEGARVTAVTADLTDPDAVERLAETAFDRLGDIDVVCNNAGVLGPVGQPLWEVP
                     LERMRQVFEVNHWAHVLVARAFVPRLLERGRPAHLIHTASMSAFVVGAGSAAYAASKHA
                     DLAVARSLRADPPGDLRGTAVRVSVLCPGRVDTPMVEGLTAPRGAGGDTSVSAEDVAGV
                     VWEALGSDRFYLFSNSDAPLRLRDQFDDVWRHVPLPPPSPEEELWPVPKTTTATTATTK
                     H"
     CDS_motif       8497..8637
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pntF_0001"
                     /evalue="5.50E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="pntF"
                     /protein_end="55"
                     /protein_start="8"
                     /score="12.6"
                     /tool="antismash"
                     /translation="VVTGAASGIGLALSARFARAGAGVVMADVEGGALHRRAAELIAEG
                     AR"
     aSDomain        8497..8994
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pntF_PKS_KR.1"
                     /evalue="4.80E-12"
                     /label="pntF_PKS_KR.1"
                     /locus_tag="pntF"
                     /protein_end="174"
                     /protein_start="8"
                     /score="38.0"
                     /tool="antismash"
                     /translation="VVTGAASGIGLALSARFARAGAGVVMADVEGGALHRRAAELIAEG
                     ARVTAVTADLTDPDAVERLAETAFDRLGDIDVVCNNAGVLGPVGQPLWEVPLERMRQVF
                     EVNHWAHVLVARAFVPRLLERGRPAHLIHTASMSAFVVGAGSAAYAASKHADLAVARSL
                     RAD"
     gene            9324..11093
                     /gene="pntE"
     CDS             9324..11093
                     /codon_start=1
                     /gene="pntE"
                     /gene_functions="other (smcogs) SMCOG1092:hypothetical
                     protein (Score: 399.4; E-value: 4.4e-121)"
                     /gene_kind="other"
                     /note="Baeyer-Villiger monooxygenase"
                     /product="PntE"
                     /protein_id="ADO85575.1"
                     /transl_table=11
                     /translation="MDLEAVREKYRQERDKRGVGRTYQFARGDFSRYARDPYTERRERE
                     PLTDEVDVAVVGAGIGGLLTGARLREETGLERIRLIDEAGDVGGTWYWNRFPGVRCDVE
                     SYVYMPLLEEIGTIPTEKYSTGPEIFAHLQRIAHRYGLYRDALFQTTVTELRWDEAAAR
                     WLVSTDRGDLFRARYVAMSIGLMHRPKLPGLPGLETFAGHSFHTSRWDFGYTGGDSTGG
                     LTGLKDKRVGVIGTGSTTVQLAPHLAEWAERLYIFQRTPAAVDVRGNRPTPPGWADGLD
                     AGWQQRRMENFHALTSGIPQDEDLVQDRWTQTTAELATAILPTGDTGGDPKERALAAER
                     ADFRKMEELRARIDSVVTDPATAAALKPYYRVYCKRPCFHDGYLQTFNRPNVTLVDTQG
                     QGVERLTASGVVANGREYPVDCLIFATGYEHEFAVPYTERAGYDIVGRGGVRLSEKWAQ
                     GAHTLHGLQVHGFPNCFILSKVQAGRHVNIAYMLGEQTRHLAHIVKCVEERGHRVVEAS
                     EAGEKEWVEEILRLASGDLDFLENCTPGLYNNEGDPGGLPLLNSSYGGGSVEFVNILRR
                     WREAGDLAGLELR"
     gene            11130..12029
                     /gene="pntD"
     CDS             11130..12029
                     /NRPS_PKS="Domain: TauD (21-281). E-value: 5.3e-52. Score:
                     169.0. Matches aSDomain: nrpspksdomains_pntD_TauD.1"
                     /codon_start=1
                     /gene="pntD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121:dioxygenase, TauD/TfdA (Score: 255.5; E-value:
                     8.8e-78)"
                     /gene_kind="biosynthetic-additional"
                     /note="non-heme iron/alpha-ketoglutarate-dependent
                     dioxygenase"
                     /product="PntD"
                     /protein_id="ADO85576.1"
                     /sec_met_domain="TauD (E-value: 1.6e-52, bitscore: 169.0,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVTPIPGAPLGAVVHGARVTGDMDKTHLEEIWSALDTYLVLVLR
                     GHETPSYEEFLAFGRRFGHIPKTGLTSGAHPEHNEILIVSNLVEDGRKIGVGDAEWMGW
                     HTDYSFRPRVSQVGFLEAVEVPYSGGGETLFTDMYALYESLSPEERRRLHSFRVRHALR
                     TGYEETIEEELQREVTLGEGADRIQPEDGTSTVHPLIARNPRTGRRSVYISTLNTERIV
                     DLAPDDSRELLDGLLAHAGKPQYTYAHTWQPGDLVVWDQLGTVHAKQAFDPAERRVMRQ
                     VVSIFDDPAGPWRAEAAA"
     aSDomain        11193..11972
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pntD_TauD.1"
                     /evalue="5.30E-52"
                     /label="pntD_TauD.1"
                     /locus_tag="pntD"
                     /protein_end="281"
                     /protein_start="21"
                     /score="169.0"
                     /tool="antismash"
                     /translation="GDMDKTHLEEIWSALDTYLVLVLRGHETPSYEEFLAFGRRFGHIP
                     KTGLTSGAHPEHNEILIVSNLVEDGRKIGVGDAEWMGWHTDYSFRPRVSQVGFLEAVEV
                     PYSGGGETLFTDMYALYESLSPEERRRLHSFRVRHALRTGYEETIEEELQREVTLGEGA
                     DRIQPEDGTSTVHPLIARNPRTGRRSVYISTLNTERIVDLAPDDSRELLDGLLAHAGKP
                     QYTYAHTWQPGDLVVWDQLGTVHAKQAFDPAERRVMRQ"
     gene            12026..13039
                     /gene="pntB"
     CDS             12026..13039
                     /codon_start=1
                     /gene="pntB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 290.1; E-value:
                     2.7e-88)"
                     /gene_kind="biosynthetic-additional"
                     /note="polyprenyl diphosphate synthase"
                     /product="PntB"
                     /protein_id="ADO85577.1"
                     /transl_table=11
                     /translation="MSAAPACLSHSRVTITPALRAAVARLDRRSRHQAAYHFGWITAGG
                     APTSADAGKAVRPALALLSAEAVGAAPEVALPGAVAVELVHNFSLVHDDLMDGDEERRH
                     RRTVWKLWGPSSAILTGDAMLALAQEVLLDTGLPTAASAARLLARTTRHLIRGQVQDLA
                     FEQRSHVTVEECVDMAAGKTGALLSASAAIGAVLAGAPEATVDALALYGDQVGVAFQLV
                     DDVLGIWGDPAVTGKPVHSDLRSRKKTLPVSHALNQEGPLGDELATWLTARGRPDEEEL
                     RRVARLVEDAGGRRWALAEAARRMALAEEALCGVELEAGARDELLALGRFVVDREV"
     gene            13164..14177
                     /gene="pntA"
     CDS             13164..14177
                     /codon_start=1
                     /gene="pntA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Terpene_synth_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Terpene synthase/cyclase metal-binding domain
                     protein (Score: 253.3; E-value: 6.2e-77)"
                     /gene_kind="biosynthetic"
                     /note="pentalenene synthease"
                     /product="PntA"
                     /protein_id="ADO85578.1"
                     /sec_met_domain="Terpene_synth_C (E-value: 1.3e-51,
                     bitscore: 165.7, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQDVDFHIPLPGRQSPDFARADAEQLAWPRSLGLINSEAAAERH
                     LRGGYADLASRFYPHATGADLDLGVDLMSWFFLFDDLFDGPRGENPQETKQLTDAVAAA
                     LDGPLPDTAPPIAHGFADIWRRTSEGMTPAWCARSARHWRSYFDGYVDEAESRFWDTPY
                     DSAAQYLAVRRQTIGVQPTVDLAERAGRFEVPHRVFDSAVLSAMLQIAVDVNLLLNDIA
                     SLEKEEARGEQNNMVMILRREHGWSKDRSVAHIQSEVRVRLEQYLVLESCLPQVGDIYR
                     LDDAEREALERYRDDAVRTVIRGSYDWHRSSGRYDAEFALAAGAQGYLEELGRITH"
     gene            14292..15665
                     /gene="pntI"
     CDS             14292..15665
                     /codon_start=1
                     /gene="pntI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 395.2; E-value: 7e-120)"
                     /gene_kind="biosynthetic-additional"
                     /note="cytochrome P450 monooxygenase"
                     /product="PntI"
                     /protein_id="ADO85579.1"
                     /sec_met_domain="p450 (E-value: 4.6e-81, bitscore: 262.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEQTTFSAGAAPGALPVVGHALQMMRHPVNFMTSLSAHGDLVEI
                     KIGPTRAYVPTHPELLRHVLTNDRLFDKGGVFYDRARDIAGNGLVTCPFADHRRQRRLM
                     QSAFTRGQLKRYAEAMRAEIEDTTSRWQDGMVVDAFQEMYGMALRTVGRTLYSTPVSPE
                     LAAQVERSFDVVLNGLFRQMFLPASIRRLPLPSQRRYRSNLHFLHETTQRFIDDYRSSD
                     TERDDLLAALLASRDDDGGRLGDKEIHDQVITVMAAGTETVAGTLTWVFYLLSQHPEIE
                     AALYDEIDTVLDGRAPQWDDLPNLSLADRIISETLRLHPPAWLFTRLTASPTELAGRRL
                     PAGSTVVFSPAAVAQYEDAFVRPAEFDPDRWLPDRVAPAARHAYVPFGTGARKCIGDLY
                     ARTEATLGLATVLGRWRVTCEPGMDVRPVPLATVYHPRRLRLRLDARTPRRIESRLTR"
     CDS             complement(15804..16871)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1158:ornithine cyclodeaminase (Score: 404.7; E-value:
                     3.5e-123)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf1; ArcB4"
                     /product="ornithine cyclodeaminase"
                     /protein_id="ADO85580.1"
                     /transl_table=11
                     /translation="MDRYQGSRHMLQPPSFVVISGAQVQAATSGREEEITRIVRAAYEL
                     HGAGLTVNPDSYFLRFPDRPSARIIALPASIGGETDVHGMKWISSFPENVASGLPRASA
                     VLILNDTRTGYPFACLEASIISASRTAASAALAAVELRARREESADAGRPVRVGFFGTG
                     LIARYVHTYLAGNGLVFGEVGVHDAVPEHAEGFRGYLARTEKAPVTVHDSPEDLVRGSD
                     LVVFATVAGEPHVTDPSWFTHNPLVLHLSLRDLAPEIILSSYNVVDDVEHSMKANTSLH
                     LTEQRVGNRDFVAGSLYDVLHGKTTPPGDRPVVFSPFGLGVLDLAVARYVHERLGATGD
                     LRTVPDFFHDLNRYG"
     CDS             complement(17047..18513)
                     /NRPS_PKS="Domain: Condensation_LCL (51-343). E-value:
                     5.3e-76. Score: 247.3. Matches aSDomain:
                     nrpspksdomains_ADO85581.1_Condensation_LCL.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     285.5; E-value: 1.5e-86)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf2"
                     /product="nonribosomal peptide synthetase"
                     /protein_id="ADO85581.1"
                     /sec_met_domain="Condensation (E-value: 3.8e-52, bitscore:
                     167.3, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPPPEEPAAPAIPPVAPGLAARAELEAGLLRRLRGTRATIPVVP
                     RPQGVARFPASPAQEWAWTRTRARPRPAPVVLAGMRLRGPLDTTALEQALNAALARHEI
                     LRTVLREAEDGRLTQVVSPALRLRIPVTDGTLADFDALTRAEVDQLPGLAHGPLVRARL
                     LRLDVEDHIVIVVLHHMVADARATEILLADLAAAYLAARAGRPAALPPPPLQYADYAVW
                     QRDRTSDAHRSRRTGYWTRRLAGALPPSLPSDRPHPDLPAELGDAVVLPLPGGLPAALR
                     ACVREHGTTVFVGALTAFQVLLARYTGSRDISVPAPVTFRDRRELEDMIGDFSHPMVCR
                     TDLSGSPTFASLLPQVRDAFAQDLQHADLPPHLLTPRLAGPDELSDLLDGLEFGAERAA
                     DAQELGGGLSATPMPPRWPYALRPLSVRLSHRPDGGDLVLTYRRRDFSPGRARDLGRDY
                     LSVLAACLDSPGAEVFGPRAPGLRVPPSSG"
     aSDomain        complement(17485..18360)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ADO85581.1_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="5.30E-76"
                     /label="ADO85581.1_Condensation_LCL.1"
                     /locus_tag="ADO85581.1"
                     /protein_end="343"
                     /protein_start="51"
                     /score="247.3"
                     /tool="antismash"
                     /translation="RFPASPAQEWAWTRTRARPRPAPVVLAGMRLRGPLDTTALEQALN
                     AALARHEILRTVLREAEDGRLTQVVSPALRLRIPVTDGTLADFDALTRAEVDQLPGLAH
                     GPLVRARLLRLDVEDHIVIVVLHHMVADARATEILLADLAAAYLAARAGRPAALPPPPL
                     QYADYAVWQRDRTSDAHRSRRTGYWTRRLAGALPPSLPSDRPHPDLPAELGDAVVLPLP
                     GGLPAALRACVREHGTTVFVGALTAFQVLLARYTGSRDISVPAPVTFRDRRELEDMIGD
                     FSHPMVCRTDL"
     CDS_motif       complement(17647..17679)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ADO85581.1_0004"
                     /evalue="8.10E-01"
                     /label="Cy2"
                     /locus_tag="ADO85581.1"
                     /protein_end="289"
                     /protein_start="278"
                     /score="2.7"
                     /tool="antismash"
                     /translation="ALRACVREHGT"
     CDS_motif       complement(17836..17871)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ADO85581.1_0003"
                     /evalue="5.20E-06"
                     /label="C4_LCL_164-176"
                     /locus_tag="ADO85581.1"
                     /protein_end="226"
                     /protein_start="214"
                     /score="18.9"
                     /tool="antismash"
                     /translation="QYADYAVWQRDR"
     CDS_motif       complement(17920..17985)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ADO85581.1_0002"
                     /evalue="1.70E-05"
                     /label="C3_LCL_132-143"
                     /locus_tag="ADO85581.1"
                     /protein_end="198"
                     /protein_start="176"
                     /score="17.5"
                     /tool="antismash"
                     /translation="LHHMVADARATEILLADLAAAY"
     CDS_motif       complement(18187..18282)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ADO85581.1_0001"
                     /evalue="6.00E-14"
                     /label="C2_LCL_024-062"
                     /locus_tag="ADO85581.1"
                     /protein_end="109"
                     /protein_start="77"
                     /score="44.4"
                     /tool="antismash"
                     /translation="AGMRLRGPLDTTALEQALNAALARHEILRTVL"
     CDS             complement(18517..19272)
                     /NRPS_PKS="Domain: Thioesterase (20-225). E-value: 1.9e-28.
                     Score: 92.2. Matches aSDomain:
                     nrpspksdomains_ADO85582.1_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004:thioesterase (Score: 173.6; E-value: 6.3e-53)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf3"
                     /product="thioesterase II"
                     /protein_id="ADO85582.1"
                     /transl_table=11
                     /translation="MTGNRRPRWFLEEPSPDAGARLFALPYSGCGASMYRKWPRFTGDV
                     ELCPVQFPGRENRLREDPFMSFGSLADMLCEALLPYLDRPFAFFGHCSSALIAYETALR
                     LERRGYPVPARLFVSSQVAPHKGVHGRFLDMSDDELREEVRTLITELGGVPRPDMVELS
                     LEVLLFDVAAHKRYGVADPDPLPCPATVLGWDEDVEVPHQLLHEWSDLGETTFTLLKGP
                     HYGFLEGPDELMRTFATGLGRAPGPSLAG"
     aSDomain        complement(18598..19212)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ADO85582.1_Thioesterase.1"
                     /evalue="1.90E-28"
                     /label="ADO85582.1_Thioesterase.1"
                     /locus_tag="ADO85582.1"
                     /protein_end="225"
                     /protein_start="20"
                     /score="92.2"
                     /tool="antismash"
                     /translation="RLFALPYSGCGASMYRKWPRFTGDVELCPVQFPGRENRLREDPFM
                     SFGSLADMLCEALLPYLDRPFAFFGHCSSALIAYETALRLERRGYPVPARLFVSSQVAP
                     HKGVHGRFLDMSDDELREEVRTLITELGGVPRPDMVELSLEVLLFDVAAHKRYGVADPD
                     PLPCPATVLGWDEDVEVPHQLLHEWSDLGETTFTLLKGPHYG"
     CDS_motif       complement(18958..19023)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ADO85582.1_0001"
                     /evalue="2.00E-04"
                     /label="NRPS-te1"
                     /locus_tag="ADO85582.1"
                     /protein_end="105"
                     /protein_start="83"
                     /score="14.0"
                     /tool="antismash"
                     /translation="RPFAFFGHCSSALIAYETALRL"
     CDS             complement(19269..20930)
                     /NRPS_PKS="Domain: Condensation_LCL (8-300). E-value:
                     2.6e-106. Score: 346.8. Matches aSDomain:
                     nrpspksdomains_ADO85583.1_Condensation_LCL.1"
                     /NRPS_PKS="Domain: PCP (464-532). E-value: 9.6e-20. Score:
                     62.5. Matches aSDomain: nrpspksdomains_ADO85583.1_PCP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     412.9; E-value: 3.1e-125)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf4"
                     /product="nonribosomal peptide synthetase"
                     /protein_id="ADO85583.1"
                     /sec_met_domain="Condensation (E-value: 2.2e-68, bitscore:
                     220.6, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 9.1e-17, bitscore:
                     51.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDDEVLVFPASFAQRSMWLENEINPGRPTYHVLAALRLRGRLDT
                     EALRRALNTVVDRHEALRTVFDLDEDGPVQIIGPAPELDVPVTDVARGDLEAAVTAEVT
                     KPFDLYRGPLVRMRLLRTAPEEHVAVLVMHHIVTDGVSSALFVAELTACYGAYLRGEEP
                     GLPPLEIQYADFTMWQHENLRGEKLSGLTRRWQRRLDGAPPLRLFTDRPYPAEPTFAGD
                     THTFTVPAPLVSRLDALARQERATAFMVFLAAFDVLLSRYSGQQDITVASPTAGRTRPE
                     LAGLIGFFVNPLLLRTDVSGEPTARELIGRVRNNCAEAFDDQEFPFESALELLRVQRRS
                     TAGTPQVQAMLVLQNMPVPELRTPDLVIEPLRPDSKAASYELALDLEPDDETGYRAFLE
                     YSSELFDAATVTEMAAEFVTILEGIAADPDAPVSTKPVDRQPMPWSEEPAQPAADVPYR
                     APQTPIELELHEMFCELLGLERIGVDDDFLDLGGDSLSLLQLRNRVRQEYGVEFPVREL
                     FGRVDIDGLARRVLERLLAQDENGRSPQSSPNEEHP"
     aSDomain        complement(19335..19538)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ADO85583.1_PCP.1"
                     /evalue="9.60E-20"
                     /label="ADO85583.1_PCP.1"
                     /locus_tag="ADO85583.1"
                     /protein_end="532"
                     /protein_start="464"
                     /score="62.5"
                     /tool="antismash"
                     /translation="ELELHEMFCELLGLERIGVDDDFLDLGGDSLSLLQLRNRVRQEYG
                     VEFPVRELFGRVDIDGLARRVLE"
     aSModule        complement(19335..20906)
                     /domains="nrpspksdomains_ADO85583.1_Condensation_LCL.1"
                     /domains="nrpspksdomains_ADO85583.1_PCP.1"
                     /incomplete
                     /locus_tags="ADO85583.1"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(19872..19994)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ADO85583.1_0005"
                     /evalue="2.90E-05"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="ADO85583.1"
                     /protein_end="353"
                     /protein_start="312"
                     /score="16.3"
                     /tool="antismash"
                     /translation="RNNCAEAFDDQEFPFESALELLRVQRRSTAGTPQVQAMLVL"
     aSDomain        complement(20031..20906)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ADO85583.1_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="2.60E-106"
                     /label="ADO85583.1_Condensation_LCL.1"
                     /locus_tag="ADO85583.1"
                     /protein_end="300"
                     /protein_start="8"
                     /score="346.8"
                     /tool="antismash"
                     /translation="FPASFAQRSMWLENEINPGRPTYHVLAALRLRGRLDTEALRRALN
                     TVVDRHEALRTVFDLDEDGPVQIIGPAPELDVPVTDVARGDLEAAVTAEVTKPFDLYRG
                     PLVRMRLLRTAPEEHVAVLVMHHIVTDGVSSALFVAELTACYGAYLRGEEPGLPPLEIQ
                     YADFTMWQHENLRGEKLSGLTRRWQRRLDGAPPLRLFTDRPYPAEPTFAGDTHTFTVPA
                     PLVSRLDALARQERATAFMVFLAAFDVLLSRYSGQQDITVASPTAGRTRPELAGLIGFF
                     VNPLLLRTDVS"
     CDS_motif       complement(20043..20132)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ADO85583.1_0004"
                     /evalue="4.40E-14"
                     /label="C5_LCL_267-296"
                     /locus_tag="ADO85583.1"
                     /protein_end="296"
                     /protein_start="266"
                     /score="44.8"
                     /tool="antismash"
                     /translation="DITVASPTAGRTRPELAGLIGFFVNPLLLR"
     CDS_motif       complement(20382..20420)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ADO85583.1_0003"
                     /evalue="6.80E-05"
                     /label="C4_LCL_164-176"
                     /locus_tag="ADO85583.1"
                     /protein_end="183"
                     /protein_start="170"
                     /score="15.4"
                     /tool="antismash"
                     /translation="QYADFTMWQHENL"
     CDS_motif       complement(20469..20534)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ADO85583.1_0002"
                     /evalue="6.80E-09"
                     /label="C3_LCL_132-143"
                     /locus_tag="ADO85583.1"
                     /protein_end="154"
                     /protein_start="132"
                     /score="28.2"
                     /tool="antismash"
                     /translation="MHHIVTDGVSSALFVAELTACY"
     CDS_motif       complement(20733..20846)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ADO85583.1_0001"
                     /evalue="1.90E-19"
                     /label="C2_LCL_024-062"
                     /locus_tag="ADO85583.1"
                     /protein_end="66"
                     /protein_start="28"
                     /score="62.1"
                     /tool="antismash"
                     /translation="PTYHVLAALRLRGRLDTEALRRALNTVVDRHEALRTVF"
     CDS             complement(20923..>21694)
                     /NRPS_PKS="Domain: PCP (147-215). E-value: 3.8e-24. Score:
                     76.6. Matches aSDomain: nrpspksdomains_ADO85584.1_PCP.1"
                     /codon_start=2
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf5"
                     /product="nonribosomal peptide synthetase"
                     /protein_id="ADO85584.1"
                     /sec_met_domain="PP-binding (E-value: 6.4e-19, bitscore:
                     58.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPADRDVDPVALLAVAHAAGYEAAAGPSGTRLDELTVALRAQSAE
                     PGSAVPLSRLLSGGYTRAEPAAAAPAPDPAFGAWARSMPALLRGYLRDRLPLHAVPATV
                     EPVTAWPLRTDGHLDVTAFPPPYETSEVRTKGREAVKNLTTTQQRVLKIWADVLGVDNP
                     GIHDDFFALGGHSLMGAAVIDRLRNEFELDLPLGQLFQTPTVAEVSAYIDEQAQAPEPE
                     ETPAIRPRDRSAFRRKRPSGSGRTPTTGEGAARD"
     aSDomain        complement(21049..21252)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ADO85584.1_PCP.1"
                     /evalue="3.80E-24"
                     /label="ADO85584.1_PCP.1"
                     /locus_tag="ADO85584.1"
                     /protein_end="215"
                     /protein_start="147"
                     /score="76.6"
                     /tool="antismash"
                     /translation="QRVLKIWADVLGVDNPGIHDDFFALGGHSLMGAAVIDRLRNEFEL
                     DLPLGQLFQTPTVAEVSAYIDEQ"
ORIGIN
        1 ggatccgccg gggcagggag tgcggctgtc cggtggcgag atcccacacc tgcgccggga
       61 gaccggagtc gccggccggt gtcgccacga ggcggcgggc gtccggggag aagtcgagga
      121 tcttcaggtc gtccatgccg gacgaggccg ccagcgagat gtgggagaag gcgccctcga
      181 gctcgtgggc ccgtcccacg agctccttcg caccaggcgt cacgtcacgc cacaccacca
      241 ccccgtcgcc gtcgcggaca taggcgatcc gccgcccgtc ccggctcacg gccggcacca
      301 gcacgttctc ggcgaggttc agctgccgcg tgcgcacccg gccgtcggct ccccgtacga
      361 agagggtggc ccggcccgtc tcggaggtca ccagggtgac ccgtccgtct gcgctcatcg
      421 ccgcggcatt gagctccccc tcggcgccgg acagcagcca cgccgtccgg cgctgctcct
      481 ggtagcgccg catcagcgca ctgcgggcct cctgcgtcgg cgcgacctcg tacgcggcca
      541 cggcggccag cgcggccgtc cccgggtcgc tgtcggtcag ttcgtccgag cggacggcca
      601 gcgcgcgtga acgtccctcg gcctgccgct cggtgctcac ctgcgactgt tgcatcaggt
      661 acgtgaggag actggcgatc agggtcaggg cgagggcggc cgcgacgagc gcggtgcccc
      721 gcaggcggcg gcgggcgcgc acgcggcggc gcaccgaggt gaggaactcc cgctccgcgg
      781 cgtccagttc cgcttcgcgt ccggccaggt gctgcgcacc catgggaagc acggccgggc
      841 cgggaccgtt ctcctgccgg gcgcgctcca ggtcgtgccg cagttctgcc cgcgccgtga
      901 ggaacgcggc gtcggcccgg gtgacgtcgg ccagcgtcgg ccaggccgtg atcagcgcct
      961 cgtgggccag ctcggcactc tccggccggc cgtcaccccc gtacaggacg agcaggcgcc
     1021 gctcggcgag ggcctgggcc aggcgccagc ggtcctcgcc ggcctcctgc cgggtcaggg
     1081 cccggcgcaa cggggccccg ccgccgggca ggaccttgac cagcccggtc agcagtcgcc
     1141 cggcgtcgtc ctgggtgccg gacgtcacgc attccttcca gaccgattcg gcatggcggc
     1201 tcagggcgcc ggtcacacgg ccgatgtcgt ggtacgtctg cgtgcgcagg cgtccccccg
     1261 accgcttgtc ccacagttcc tggagcacga atccgagcag cggcagaaca ccgggttcac
     1321 ctcccgcgtc gtccacgatg cgctggtcca ggcccgggtc gtaccccacc gccggaatcc
     1381 gccggagcgg ctcggtgatc acgtcccgca gctggtccgg cgtcatcggg gtcaggggga
     1441 gcgtctcgcc gctctggagc gcggggccga ggtgcgggtg gcgcagcgcg gcgtccatga
     1501 agtccgcgcg cagcgtgacc aggacccgca ggcccgtggg cggccgctgg gggaagaaga
     1561 tcagcgcgat cgtctcggcg atctcctgct cggggcggtt cagcagggcc tcggcctggt
     1621 ccagtacgag caggagccgg cgggcgggcc gtccggtggc gcggtggtag gcgtcgacga
     1681 ggcccagttc ggccagccag cggtccactt ggtcgacgtc cgtggcccgg ggcgggccgt
     1741 cgtcccccgc gcgggcggct tcgtagagct ccgtggccag cgcgacgcgc agtgatccgg
     1801 cgtgtccggc gccgaggacc aggacgtcgt acgcgtcccg gcgcatcttc ggcaccacac
     1861 cggccagcac cagcgaggac ttgccgcagc cggagggtcc gtagacggtg acgaccgggt
     1921 ggccgcgcac tgcgtctacg gctttgccga tctccgccgc ccgcccgaag aagacctcgg
     1981 agtccttctc ctcgaagggc gcgagtccgc ggaacggcga ggggggatcg gcgacggctt
     2041 ccagctcgcg gaggttctcg acgatgactc gggtgtgcag ggcgaacgcc tgctgagccg
     2101 cgcgcaccgg ctcggccgcc accatcatgc ccaccacggc gtccaggtcc tcgtcccata
     2161 cgggactgcc gctgaagccc ccttcgacgt gcgcgtcctc cccgtccatg cgcgccagct
     2221 ggatccagcc gccgccggtg atgccgagga gccgcccccg gtgccagagc ccatggggat
     2281 gggcctgggt gaaccccacg acccaactcc ggtgattacg cacgctcttg gcgtccgcca
     2341 tcggcaacgg cctggccccg ggcaggggtc ggctcacccg tagcagtgcc acgtccccgg
     2401 tccggtcctc gccgagcggc acccagtcca cgacctcggc gggcgccatg ggggcagcgg
     2461 cgacgccgtc accgttgttc gcgagcagca gccgcaccgt gacccgtgcg ccgggctcga
     2521 ccgtggcctc cggtggcagg tccagggcgt cggacaccac atgggcgcag gtcaggatca
     2581 gttcaggagt gacgaagaag ccggcaccgc ccccgccacc gcccccgctc gggtcttcgt
     2641 cccgccggtc acccgtgaca cggacgacgg cggcggccag gagcggctcc gtctcttctg
     2701 cgctcaaccg tcctgccccc tgaccggccc gagaaccaca tggatcgcac gcccgtgctt
     2761 tgcgtcaacg ccctttgtac agagggtagt ttccaattcc gagtggttcc cggaagccct
     2821 gttgtctttc tcgtccgtgc ccgagcacgt cgacttccga ctcatcggcc gggtcgcgcg
     2881 atcgcgccta ccgtgcggct tcggctccga gttcggccag gcgggtgagg gcgggcaggg
     2941 ccgcggcgat cgcctgtcgt tcggcgggcg tcagctgggc gatcaggggg atcaggtggc
     3001 ggccccggtc ctcgcgccgg gactggccga tcttccggcc gctgtccgtg atgtggacga
     3061 ggacggcgcg tccgtcggcc gggtcggggt ggcgccggac caggtcgtct cgctcgagcc
     3121 gggtgaccag ctgggtgagc cccggctggc tgatctgctc ggtcctggcg agttcggtga
     3181 gccgcttcgg accgctgagg gccagtgtgt ccagcacgga cagagtcgtg aacgacagct
     3241 tctgcaccgc gggaagccgg atgtagtagc ggttgaagtt ctcgatcgcc ctggtgaggt
     3301 cacccacgtc caagtcggtg ttctggtcgg cacgctgagt aggagtcacc ctggaaatgt
     3361 atcgcagact tatataagct cctgatcgat tgcgtgccgg acgccgcgtc caggcgtacg
     3421 gcccgcgttg cacctcggcg caacggcgcg tcaacggatt tgtagagcgc taggtgagga
     3481 acacaccaaa tgactgtgcg aatcggcatc aacggcttcg ggcgcatcgg ccgcaacgtc
     3541 ttccgggcgg cggccgcgcg gtcctcggag ctggagatcg tcgccgtcaa cgacctgggc
     3601 gacgtgccca cgatggccca cctgctcgcc tatgactcga tcctcggacg cttccccgag
     3661 gaggtcaccg ccgaaccggg cgcgatccgc gtgggcgacc ggacgatcaa ggtcctcgcc
     3721 gagcgcgacc ccggcgccct gccgtggggc gacctgggag tggacatcgt gatcgagtcc
     3781 accggcatct tcaccgacgc cgcgaaggcg cgctcgcacg tcgacggcgg agcgaagaag
     3841 gtcatcatcg ccgctccggc cagcggcgag gacttcacgg tggtgctggg cgtcaacgac
     3901 ggcgactacg atcccgagcg ccacaccatc atctccaacg cctcctgcac taccaactgc
     3961 ctcggcgtac tggccaaggt gctgcacgac gccgtcggca tcgacagcgg catgatgacc
     4021 acggtccacg cctacacgca ggaccagaac ctccaggacg ccccgcacaa ggacctgcgc
     4081 cgggcccggg ccgcggccct gaacatcgtg cccacctcca gcggcgccgc caaggccatc
     4141 ggcctcgtcc tgccggaact cgcaggccgg ctggacgcct tcgccctgcg ggtgcccgtc
     4201 cccaccggct cggtcaccga cctcaccgtc accacccgcc gcggcacctc ggtggaggag
     4261 gtgaaggagg cgtacgcggc cgcggcctcg ggaccgtaca agggcttgct gtcctacgtg
     4321 gacgcgcccc tggtgagcac cgacatcgtg ggcgacccgg cctcctgcgt cttcgacgcc
     4381 gggctcaccc gggtgtccgg cccgcaggtc aaggtcgtcg gctggtacga caacgagtgg
     4441 ggttactcca accgcctcat cgacctggcg acgctcatcg ggtcgtccct gtagctcctc
     4501 gccgacccgg cgtctgcacc acccgcacgt cagcaacggt cggccgcccc ggcggcggcc
     4561 gccgtttcgg cgcgcccgtg aaccggcgcg cagcgcaccc gacgcggcga acgccgtcgg
     4621 cgtgcccgga tgcccgacga ctcccacgca cgacgccacg aggacggacc acatgacgga
     4681 tctcccgagg ttaccgttcg acaacccgga catcatgggc atcgcccccc agatgctcgc
     4741 actgcagaag gaggggccga tcgcccgggt ggggaccgcc ggtgaggacg cctggctggt
     4801 cacccgctac gacgaggtac ggaccctgct cgccgaccgc cggctccgtc tcagcaatcc
     4861 caacccgcag ccgtccgcca agagcgccgc cagggccttc atggtcgcgt tgatggccgg
     4921 ggacgaccac gagaccgagc cggccaggca cgcgcagatg cgctcgctgc tcataccccg
     4981 gttctccacg cgccggctgc gcctgatgaa gacgcggatc gagcaccatg tcgacgagct
     5041 gctcgaccag ttggccgcca gtgccccgcc ggtcgacctg caccgcgtgc tgtcgttccg
     5101 gttgccgacc atggtggtct gcgacctgct cggcgtgccg ttggccgacc gggagcggtt
     5161 cgggcagtgg gcgaggggca cgttcgacca gagcgacaac gagcactccg cgaacacctt
     5221 ccagcaggtc gtcgactaca tgctggaact cgtggcacgc aagagggtcg agccgggcga
     5281 cgacatcctg tccgagctga tcgccgagaa ggacggcgcg ctgtccgacg cggacatcgc
     5341 ccatctgggc aacgccgtgc tcctgttcgg ctacgagacc accatcgtcc gcatcgacct
     5401 gggcaccctg ctgctgctgc gcaatccggt gcagcgtgcc cagttggccg aggatcccgg
     5461 actcgcgccg gccgcggtgg aggagatcct gcgcctgggc gtcggcggca aggggtccaa
     5521 cgcgctgatc ccccgctacg cgcacggcga catcaccgtc ggggagacgg tgatccggac
     5581 cggggacgcg gtgatgctcg ccatcggcgc ggccaactac gacgaccggg cgttccccga
     5641 cggcggcctg ttcgacctga cccgggtcag gcccaggtcg cacctggcgt tcgggcacgg
     5701 cgcccggcac tgcatcggcc gcacgctggc ccggatcgag ctcaccgcgg tgttcgagcg
     5761 gctgttccgc agactgcccg acctgcggct cgcggtgccc gaggagtcgc tgcgctggca
     5821 ggagcaccgc atcaccggcg ggttcgacga aattcccgtc accttctgag tgacgtcgcg
     5881 ccggcgaaag cagcgccgtc cacccttcat ggtcgtagac ggcgcccgcc gccggatcga
     5941 gaccgtccgc ccacccggat cttcgacgct ccctccccta cgcacagacg tcacgaggac
     6001 aaggaaccat gacggacact ttcagcgact acgccgactg cacgcctctg ctcgacgacc
     6061 gtgaggccct cgaccggttc tacgacgagc acggctacgt ctatctgcgc ggcgtcctgg
     6121 accgtgaact cgtgcggacc accgccgagc agatgctgca gggcctgatc gcgctcggcc
     6181 acgccgcccc cggcaccacg ctcgacaccc tcaccatcga gtcctacgag gcggtcgacg
     6241 aggtggcgat gcacgaccac gtcaggtacg acgacctgtg gaaccacccc tcgaccctca
     6301 aggtgtggga gaaggtcttc ggcgagcccg tcttcgtctt caagtcgacg acgatccgct
     6361 actacccctc ggcgccggac tccgcggagc cgagtttcct gacgccactg caccaggacg
     6421 gcttctacat aggcccgaac aaggacttcc gcaccgcctg gataccgctg ctcccgacga
     6481 cccggggcac gggcggcgtc gccatcgccg acggcagcca caagaagggc ccgcgcgagc
     6541 acgtcctcac cgagaacttc cgccgcttcg gccacgccgt gcgcggcata ccgcccgccg
     6601 agttcggcgc ggacgaggaa ctgctgttct cacccatgga accgggtgac gttctcctct
     6661 tccacgcctt catgtgccac aagtccctgc cgaacgtctc ggtggacccg gccggcatgc
     6721 ggatgtcgat ggacacccgt atccagcccg cctcctcgca ccggggtttc aacgccctga
     6781 ccccctggcc ggagtccgcg aaggacgcct ccaagggaat catgtcgaag atcaccggca
     6841 ctcccaccac cgccgagtga cgtcgggctt cccgaacccg cctcaaccgt cccccaccga
     6901 agcctggtag gcaacgcatg acgaaacgcg agggtctccc ccctttgacg gggcccagcg
     6961 cggcacagca gtcccgggtc ggcacggcac cggccgccgc ggggctcacc ggcatcgccc
     7021 tcatggtggt gctcaccgga tacgccctgt ccatcgtgga cgcctccatc gtcaacgtgg
     7081 cgctgtcctc gatcagcgac gacctgaacg gcggcgccgc cgcgctggag ctggtggtgt
     7141 cgggctacgg cctcacctat gccgtcggcc tggtactggg cggacgtctg ggcgacgcct
     7201 tcggcaggcg gcgcctgtac gcctgggggc tggccgcgtt caccgtcacc tccgcactgt
     7261 gcggactcgc cccgaccatc gagttcctcg tcgcggcccg gctgctgcag ggcgccgcgg
     7321 ccgccatgct ggtaccgcag gtgctggcga cgatccaggc ggtcacggcg gggcaggcac
     7381 gcgcccgcgc gatcggcatg tacggggcga ccgcggccct cggcatggtc gtggggcaga
     7441 tcctgggcgg gctgctggtc tcgctggacg tcgcggggat gggctggcgg tcggtcttcg
     7501 cgatcaacgt gccgatcggc gtggccgcgc tgctgctcgt ccggcgcgtc cccgcgacca
     7561 gggccgacgc cagaccgggg ttcgacccgg tgggcaccgt gctgttcggt gtcaccatgg
     7621 tctgcctcct ggccgtcatc gtggcgggcc cggacctggg ctggccgctg tggctgtggt
     7681 cgctgctcgt ggtcgccgcg gcgacggcgc tggcgctggt gcgggccgaa cgcgcgctgg
     7741 aggcgcgggg cggctcaccg ctgctgtccc catcggtgct gtcccatccg ggcatgcgca
     7801 gggggctcgc ggcgatggtg ccgttctcgg ccggcttcgg cgccttcctg ttcgtctacg
     7861 cgctggtcgc gcagggtcac ttcggcctgg acgggctcgc ctccggcggg gtgctggtgc
     7921 cgttcgccgc ggcgttcttc gtcgtgacgc tgttcacccc gaggatcgcg gccgctctcg
     7981 gcggccggat cgtcaccctg ggcgccctcg tccagtgcgc gggcctgctg ctgctggcgc
     8041 tggtgatcgg gctgggctgg ccgcacccct ccctggcgct cgtgctcgcc ggcatcggct
     8101 gctacggagt gggcgcggcg ctgaccggcc cgacgctgtt ccggatgatc ctcgccgacg
     8161 tacccgcggc gcaggcgggc atgggcagcg gggtgctggt gacgagccag cagatggcga
     8221 ccgcgctggg cgcgaccgtc ggcgggaccc tgtacgtctc cctgtccggt tggctgtcga
     8281 ccgtcacggc tgccgtgctc gtcgtcgtcc tgctggcgtg tttcgcggtg accgtcctgc
     8341 tgatcagcct gaagctcccc gacccccggt gacaccccgg cccccgaacg gcgcgatctg
     8401 atccagacct tctcgtcggc aagcggcgcg ccgtccttcg gcgttcccgc acgcggaagc
     8461 ggagacagcg aagtgcactc acagacaagg gcggccgtgg tgaccggcgc ggccagcggc
     8521 atcggcctcg cgctcagcgc ccgcttcgca cgggccggcg ccggcgtcgt catggccgac
     8581 gtcgagggcg gcgcgctgca ccgcagggcc gccgaactca tcgcggaggg cgcccgggtc
     8641 accgccgtga ccgccgacct gaccgacccg gacgccgtcg agcggctcgc ggagacggcg
     8701 ttcgaccggc tcggcgacat cgacgtggtg tgcaacaacg ccggagtcct cggccccgtg
     8761 gggcagccgc tgtgggaagt gccgctggag cggatgcggc aggtcttcga ggtgaaccac
     8821 tgggcgcacg tcctggtggc ccgcgccttc gtaccccggc tgctggagcg cggccggccc
     8881 gcccatctga tccacaccgc ctcgatgtcc gccttcgtcg tcggcgcggg cagcgccgcc
     8941 tacgccgcct ccaagcacgc cgacctcgcc gtcgcccgca gtctgcgcgc cgatcccccc
     9001 ggtgatctgc ggggcaccgc ggtccgggtg tcggtgctgt gtcccggacg ggtcgacacc
     9061 cccatggtcg agggcctgac ggctccgcgc ggcgcgggcg gcgacacctc ggtgagcgcc
     9121 gaggacgtcg ccggagtcgt gtgggaggcc ctcggctccg accgcttcta tctcttcagc
     9181 aactccgacg ccccgctgcg gctgcgcgat cagttcgacg acgtatggcg tcatgttccc
     9241 cttccgcccc cttcccccga ggaggagctg tggcccgtgc cgaaaacgac gaccgcgacg
     9301 accgcgacga cgaaacactg accgtggacc tggaagcggt gagggagaag taccggcagg
     9361 agcgcgacaa gcgcggcgtc ggccgcacct accagttcgc gcgcggtgac ttcagccgct
     9421 acgcgcggga cccctacacc gagcggcggg agcgcgaacc gctcaccgac gaggtggacg
     9481 tcgccgtcgt cggcgccggc atcggcggtc tgctgaccgg cgcccgctta cgcgaggaga
     9541 ccggcctgga gcgcatccgg ctgatcgacg aggccggcga cgtcggcggc acctggtact
     9601 ggaaccgctt ccccggcgtc cggtgcgacg tggagagcta cgtctacatg ccgctgctcg
     9661 aggagatcgg caccataccc accgagaagt actccaccgg gcccgagatc ttcgcccacc
     9721 tccagcggat cgcccaccgg tacggcctct atcgcgacgc cctgttccag accaccgtca
     9781 ccgagctgcg ctgggacgag gccgccgcga ggtggctggt gagcaccgac cggggggatc
     9841 tgttccgcgc ccggtacgtg gccatgtcga tcggtctgat gcaccgcccc aaactccccg
     9901 ggctgccggg cctggagacg ttcgccgggc actccttcca caccagccgc tgggacttcg
     9961 gctacaccgg cggcgacagc accggcggcc tgaccgggct caaggacaag agggtcggcg
    10021 tcatcggcac cggctcgacg accgtccagc tcgccccgca cctcgcggag tgggccgagc
    10081 ggctgtacat cttccagcgc accccggccg cggtcgacgt ccgcggtaac cgccccacgc
    10141 cgcccggctg ggcggacggc ctcgacgcgg gctggcagca gcgccggatg gagaacttcc
    10201 acgcgctgac ctccggcatc ccgcaggacg aggacctggt ccaggaccgc tggacccaga
    10261 ccacggccga gctggccacc gcgatcctgc ccaccggcga caccggaggc gatcccaagg
    10321 agcgggcgct ggccgccgaa cgggcggact tccgcaagat ggaggagctg cgcgcccgca
    10381 tcgacagcgt cgtcaccgac cccgcgaccg cggcggccct caagccgtac taccgcgtgt
    10441 actgcaagcg gccctgcttc cacgacggtt acctgcagac cttcaaccgg cccaatgtga
    10501 ccctggtcga cacccagggg cagggcgtcg aacggctcac cgcgtccggg gtggtcgcga
    10561 acggccgcga gtacccggtc gactgcctga tcttcgccac cggctacgag cacgagttcg
    10621 ccgtcccgta caccgagcgc gcgggctacg acatcgtcgg ccgcggcggc gtgcggctgt
    10681 cggagaagtg ggcgcagggg gcgcacaccc tgcacggact ccaggtgcac ggcttcccca
    10741 actgcttcat cctgtccaag gtccaggccg ggcggcacgt caacatcgcc tacatgctgg
    10801 gcgagcagac ccggcacctc gcgcacatcg tcaagtgcgt cgaggagcgc ggccaccggg
    10861 tcgtggaggc ctccgaggcc ggcgagaagg aatgggtcga ggagatcctc cggctcgcct
    10921 cgggcgacct cgacttcctc gagaactgca cgcccggcct ctacaacaac gagggcgacc
    10981 cgggcggact gcccctgctc aactccagct acggcggcgg ctcggtggag ttcgtgaaca
    11041 tcctcaggcg ctggcgcgag gccggcgacc tggcgggcct cgaactgcgc tgaccgtccc
    11101 ccaccgtctc tgcgaaagga ggcaacgcca tggaagtgac accgataccc ggcgcccctc
    11161 tcggcgccgt cgtgcacggc gcccgggtga ccggcgacat ggacaagacg cacctggagg
    11221 agatctggtc ggcgctcgac acgtatctcg tcctcgtctt acgcggccac gagaccccct
    11281 cctacgagga gttcctggcc ttcggccgcc gcttcgggca catcccgaag accggtctga
    11341 ccagcggcgc acaccccgag cacaacgaga tcctgatcgt ctccaacctg gtggaggacg
    11401 gccgcaagat cggcgtcggc gacgccgagt ggatgggctg gcacaccgac tactccttcc
    11461 gtccccgcgt ctcccaggtc ggcttcctcg aggccgtcga agtgccgtac tccggcggcg
    11521 gggagaccct cttcaccgac atgtacgccc tgtacgagtc gctgtcgccc gaggagcggc
    11581 ggcgcctgca ctccttccgg gtccgccacg ccctgcgcac cgggtacgag gagaccatcg
    11641 aggaggagct gcagcgcgag gtgaccctcg gcgagggcgc cgaccggatc cagcccgagg
    11701 acggcacctc caccgtccac cccctcatcg cccgcaaccc gcgcaccggc cgccggtcgg
    11761 tctacatcag caccctgaac acggagcgga tcgtggacct cgcccccgac gacagccgcg
    11821 agctgctcga cggactgctc gcgcacgcgg gcaagccgca gtacacctac gcgcacacct
    11881 ggcagcccgg ggacctcgtc gtgtgggacc aactgggcac cgtgcacgcc aagcaggcct
    11941 tcgacccggc cgaacggcgc gtcatgcgcc aggtcgtcag catcttcgac gacccggccg
    12001 gcccctggcg cgcggaggcc gccgcatgag cgccgctccc gcctgcctga gccacagccg
    12061 ggtcacgatc accccggcgc tgcgcgccgc cgtcgcccgg ctcgaccgcc gctcgcgtca
    12121 ccaggcggcc taccacttcg gctggatcac cgcgggcggc gcgcccacca gcgccgacgc
    12181 cggcaaggcc gtacggccgg cgctcgcgct gctgtcggca gaggcggtcg gcgccgcgcc
    12241 ggaggtcgcc ctgccgggag ccgtcgccgt ggagctcgtg cacaacttct ccctggtgca
    12301 cgacgacctg atggacggcg acgaggagcg ccgccaccgg cgcacggtgt ggaagctgtg
    12361 gggtccctcc agcgccatcc tgaccggtga cgcgatgctg gcgctcgccc aggaggtgct
    12421 gctggacacc gggctgccga cggcggcgtc cgccgcccgg ctgctggccc ggaccacccg
    12481 gcatctgatc cgcggccagg tgcaggacct ggccttcgag cagcgctcgc acgtcacggt
    12541 cgaggagtgc gtcgacatgg ccgcgggcaa gaccggcgcg ctgctgtcgg cgagcgccgc
    12601 gatcggcgcc gtcctcgccg gggcaccgga ggcgacggtg gacgcgctgg cgctctacgg
    12661 cgatcaggtc ggcgtcgcct tccagctcgt cgacgacgtg ctcggcatct ggggcgaccc
    12721 ggccgtcacc ggcaaaccgg tccactccga cctgcgctcc cggaagaaga cgctgccggt
    12781 gagccacgcg ctgaaccagg agggcccgct cggcgacgag ctggccacct ggctcaccgc
    12841 ccgtgggcgc cccgacgagg aggaactgcg gcgcgtggcc cgtctggtcg aggacgccgg
    12901 cggccgccgc tgggcgctcg cggaggccgc ccggcggatg gcgctggccg aggaagcgct
    12961 gtgcggcgtc gaactggagg ccggcgcgcg ggacgaactc ctcgcgctcg gacggttcgt
    13021 cgtcgaccgc gaggtctgac tccaggccgc ctccctcacc ccgtcgcccc gccgcaaccg
    13081 gtgactctcc gatcagcgca gcacccccac tcgggcgcca ccgtgcccgc tgcccgtccg
    13141 aacccactcc cgaggattcc cccatgcccc aggacgtcga cttccacata cccctgccgg
    13201 gccggcagag cccggatttc gcccgtgccg acgccgagca gctcgcctgg ccgcgctcgc
    13261 tcggactgat caactcagag gcggcggccg agcgccatct gcgcggcggc tacgccgacc
    13321 tggcctcccg tttctacccc cacgccaccg gcgccgatct cgacctgggc gtcgacctga
    13381 tgtcgtggtt cttcctcttc gacgaccttt tcgacgggcc gcgcggcgag aacccgcagg
    13441 agaccaaaca gctcaccgac gcggtcgcgg cggcgctgga cggccccctc cccgacaccg
    13501 cgccccccat cgcccacggc ttcgccgaca tctggcggcg caccagcgag ggcatgacgc
    13561 ccgcctggtg cgcgcgcagc gcccggcact ggcgcagcta cttcgacggc tatgtcgacg
    13621 aggcggagag ccgtttctgg gacacgccct acgactccgc ggcgcagtac ctggccgtgc
    13681 gccggcagac catcggggtg cagcccacgg tcgacctcgc cgagcgcgcg ggccgcttcg
    13741 aggtaccgca ccgggtcttc gacagcgccg tgctgtccgc gatgctccag atcgccgtcg
    13801 acgtcaatct gctgctcaac gacatcgcgt cgctggagaa ggaagaggcc cgcggtgagc
    13861 agaacaacat ggtgatgatt ctgcgccggg agcacggctg gtccaaggac cgcagcgtcg
    13921 cccacatcca gagcgaggtg cgcgtgcgcc ttgagcagta cctcgtgctg gagtcctgcc
    13981 tgccgcaggt cggtgacatc taccggctcg acgacgccga gcgcgaggcc ctggaacgct
    14041 accgcgacga cgccgtgcgc accgtgatcc gcggttccta cgactggcac cgctcctcgg
    14101 gccgctacga cgccgagttc gcgctcgccg ccggcgccca gggatacctg gaggagctgg
    14161 gccggatcac ccactagcgg cgccgcccgg cagcggcacg ccaccgtgtc gcggccgtcc
    14221 tggcggcgtc ggccccgggc ggagcggaac ggctgtcaac agaccagtga agacgggaag
    14281 tcgaggatcg aatgaccgag cagaccacct tctcggcggg agcggcgccc ggggcgctgc
    14341 ccgtcgtggg acacgccctg cagatgatgc gtcaccccgt gaacttcatg acctcgctgt
    14401 cggcccacgg cgacctggtc gagatcaaga tcggccccac cagggcctac gtccccaccc
    14461 accccgaact gctgcggcac gtcctgacca acgaccgcct cttcgacaag ggcggcgtct
    14521 tctacgaccg cgcccgtgac atcgccggca acgggctggt cacctgcccg ttcgccgacc
    14581 accgccgcca gcgccggctg atgcagtcgg cgttcacccg cggccagctc aaacggtacg
    14641 ccgaggccat gcgggccgag atcgaggaca cgacgtcgcg ctggcaggac ggcatggtcg
    14701 tcgacgcctt ccaggagatg tacggcatgg ccctgcgcac ggtcggccgc acgctgtact
    14761 ccaccccggt cagccccgag ctggcggccc aggtggaacg ttccttcgac gtcgtgctca
    14821 acggcctgtt ccggcagatg ttcctgccgg cctcgatccg ccggctgccg ctgccctccc
    14881 agcgccggta ccggagcaac ctgcacttcc tgcacgagac cacccagcgg ttcatcgacg
    14941 actaccgcag ctccgacacc gagcgcgacg acctgctcgc cgcactgctc gcctcccgcg
    15001 acgacgacgg cggcaggctc ggcgacaagg agatccacga ccaggtcatc accgtgatgg
    15061 cggccggcac cgagaccgtc gccggcaccc tcacctgggt cttctacctc ctctcccagc
    15121 acccggagat cgaggccgcg ctctacgacg agatcgacac cgtcctcgac ggccgcgccc
    15181 cgcagtggga cgacctgccg aacctctccc tggccgaccg gatcatctcc gagacgctgc
    15241 ggctgcaccc gccggcctgg ctgttcaccc gtctgaccgc ctccccgacc gaactggcgg
    15301 gccgccggtt gccggccggt tccaccgtcg tcttcagccc cgccgcggtc gcccagtacg
    15361 aggacgcctt cgtccgtccc gcggagttcg accccgaccg ctggctgccg gaccgggtcg
    15421 cgccggcggc ccgccacgcc tacgtgccgt tcggcaccgg cgcccgcaag tgcatcggcg
    15481 acctctacgc acgcaccgag gccaccctcg ggctcgccac cgtcctcggc cgctggcggg
    15541 tcacctgcga gcccggcatg gacgtccgcc cggtcccgct ggccaccgtc taccacccgc
    15601 gccggctgcg tctgcggctg gacgcccgca ccccgcgccg aatcgagtcc cgcctcaccc
    15661 ggtgagcgcc caggaggagc gcgacacgct cactcccccg accgcgccgt acgaccacgc
    15721 cctgcgcctg ctgcgggact ccccggcgga gtcccgcgcc ggcgcggctg ctccccgctg
    15781 acgacgtggc ccgtcgccgc ctctcagccg tagcggttca ggtcgtggaa gaagtcgggg
    15841 accgtccgga gatcgcccgt ggcgccgagc cgctcgtgta cgtagcgggc gacggcgagg
    15901 tcgaggacgc cgagaccgaa cggggagaag acgaccggcc ggtcgccggg gggcgtggtc
    15961 ttcccgtgca gcacgtcgta gagcgagccg gccacgaaat cgcggttgcc gacgcgctgt
    16021 tcggtcaggt gcagcgaggt gttggccttc atcgagtgtt cgacgtcgtc gacgacgttg
    16081 tacgacgaca ggatgatctc gggggcgagg tcacgcagcg agaggtgcag gaccagcggg
    16141 ttgtgggtga accagctcgg gtcggtgacg tgcggctcgc ccgcgaccgt ggcgaagacg
    16201 acgaggtccg agccgcggac gaggtcttcg ggcgagtcgt gcacggtgac gggcgccttc
    16261 tcggtgcgcg cgaggtaacc gcggaagccc tcggcgtgct cggggaccgc gtcgtggacg
    16321 cccacttcgc cgaagacgag cccgttgccc gccagatagg tgtggacgta ccgcgcgatc
    16381 agcccggtgc cgaagaagcc gacgcggacc gggcgccccg cgtccgcgga ctcctcgcgc
    16441 cgcgcgcgga gttcgaccgc ggcgagggcc gcggacgctg cggtgcgcga ggcgctgatg
    16501 atggacgcct ccaggcaggc gaacggatac ccggtcctgg tgtcgttcag gatgagcacg
    16561 gcggaggcgc gcggaagccc ggaggctacg ttctcgggga agctggagat ccacttcatg
    16621 ccgtgcacgt cggtctcgcc tccgatcgag gcgggcagcg cgatgatccg tgcggaggga
    16681 cggtccggga agcgcaggaa gtaggagtcc gggttcacgg tcagaccggc gccgtgcagt
    16741 tcgtacgccg ctcgcacgat gcgggtgatc tcctcttccc tgccactggt cgccgcctgc
    16801 acctgggctc cggagatcac cacgaacgag ggcggttgca gcatgtgacg gctcccttgg
    16861 tatcggtcca tctcgcgcgg gccggccgga acgccgcccc gcgggcgtgg cggcactcgt
    16921 catcggtgcc ggccgggttc tcctccgcgc ctcgccatgg atagcaaggc ggggcggagc
    16981 gatcaaagac cgtgtttctc cctacagggc cacggcggtg accgacggcc gtggggattc
    17041 cacggctcag ccggacgagg ggggcacccg cagaccgggt gcccgcggcc cgaacacctc
    17101 ggctcccggg ctgtcgaggc acgcggccag cacgctgagg tagtcccggc ccaggtcccg
    17161 cgcgcggccc ggggagaagt cacgtctgcg gtaggtgaga accaggtcgc cgccgtccgg
    17221 gcggtggctg aggcgcacac tcagcggccg cagtgcgtag ggccagcggg gcggcatcgg
    17281 tgtcgcggac agccccccgc ccagctcctg ggcgtccgcc gcacgctcag cgccgaactc
    17341 cagcccgtcc agcaggtcac tgagctcgtc ggggcccgcg aggcgggggg tgagcagatg
    17401 cggcggcagg tccgcgtgct ggaggtcctg ggcgaaggcg tcccgcacct gtggcagcag
    17461 cgaggcgaag gtcgggctcc cggagaggtc ggtacggcac accatggggt gcgagaagtc
    17521 gccgatcatg tcctcgagtt cacggcggtc ccggaacgtc accggcgccg ggaccgagat
    17581 gtcccgggac cccgtgtacc gggcgaggag gacctggaac gcggtgaggg ccccgacgaa
    17641 cacggtggtg ccgtgctcgc gtacgcacgc gcgcagcgcc gccggcagcc cgccgggcag
    17701 cgggagcacc acggcgtccc cgagttccgc cggcaggtcc gggtgcggcc ggtcggacgg
    17761 gagcgagggg ggcagcgcgc cggcgagccg ccgtgtccag tagccggtcc gccgggaccg
    17821 gtgggcgtcg ctggtccggt cccgctgcca cacggcgtag tcggcgtact ggaggggcgg
    17881 cggcggaagc gccgccggtc gcccggcgcg ggcggcgagg taggcggcag cgaggtccgc
    17941 gaggaggatc tcggtggccc gggcgtccgc gaccatgtgg tggaggacca cgatcacgat
    18001 gtggtcctcg acgtcgaggc gcaacagccg ggcccggacc agcggaccgt gtgccaggcc
    18061 ggggagctgg tcgacctcgg cccgggtcaa cgcgtcgaag tccgcgagcg tcccgtccgt
    18121 gacggggatc cgcagccgca gggcgggcga gacgacttgg gtgagccggc cgtcctccgc
    18181 ctcccgcagc accgtgcgca ggatctcgtg ccgtgccagc gcggcgttca gtgcctgctc
    18241 cagcgccgtc gtgtccagcg gcccgcgcag ccgcattccg gccagcacca cgggggccgg
    18301 ccgggggcgg gcccgtgtcc tcgtccatgc ccactcctgg gccggcgacg cggggaaccg
    18361 cgcgaccccc tgggggcgcg gcaccaccgg gatggtggca cgggtgccgc gcagccgccg
    18421 gagaagtccg gcttcgagtt cggcccgggc cgcgaggccg ggagccaccg gcgggatcgc
    18481 tggggcggcg ggttcctcgg ggggcggtgc cacggctcac cctgccaggg aggggcccgg
    18541 ggcccgcccc agtccggtgg cgaaggtgcg catcagctcg tcggggcctt ccaggaaccc
    18601 gtagtgcggg cccttgagga gggtgaaggt cgtctcgccg aggtcggacc actcgtgcag
    18661 gagctggtgc gggacctcca cgtcctcgtc ccagccgagc acggtggcgg gacacggcag
    18721 cgggtcgggg tccgcgacgc cgtagcgctt gtgcgccgcc acgtcgaaga gcagtacctc
    18781 caggctgagt tccaccatgt ccgggcgggg tacgccgccg agttccgtga tgagggtgcg
    18841 gacctcctcg cggagctcgt cgtcgctcat gtcgaggaac cggccgtgca cgcccttgtg
    18901 cggggccacc tgggaggaga cgaacaggcg tgccggcacg gggtagccgc gtcgctcaag
    18961 gcggagcgcc gtctcgtagg cgatcagcgc ggaactgcag tggccgaaga aggcgaacgg
    19021 gcggtccaga taaggaagaa gcgcctcgca gagcatgtcg gcgagtgagc cgaacgacat
    19081 gaaggggtct tccctgagcc ggttctcacg gccggggaac tgcaccgggc agagctcgac
    19141 gtccccggtg aacctgggcc acttccggta catgctggcg ccgcatccgg agtacggcag
    19201 ggcgaacagg cgcgccccgg cgtccggtga cggctcctcg aggaaccagc gtgggcgacg
    19261 gtttccggtc acgggtgctc ctcgttcggg ctggactgcg gtgagcggcc gttctcgtcc
    19321 tgcgcgagga gccgttcgag tacccgacgg gccaggccgt cgatgtcgac gcgtccgaac
    19381 agctcccgca cggggaactc cacgccgtac tcctggcgta cgcggttgcg cagctggagc
    19441 agcgacagcg agtccccgcc gaggtcgagg aagtcgtcgt cgaccccgat gcgctccagt
    19501 ccgagcaact cacagaacat ctcgtgcagt tcgagctcga tgggcgtctg cggggcgcgg
    19561 taggggacgt ccgccgcggg ttgtgccggc tcttcgctcc acggcatggg ctgccggtcc
    19621 acgggcttgg tggagaccgg tgcgtcggga tcggccgcga tgccttcgag gatcgtgacg
    19681 aactcggcgg ccatctccgt gacggtcgcc gcgtcgaaca gctcgctgct gtactcgagg
    19741 aacgcccggt agccggtctc gtcgtcgggt tcgaggtcga gcgcgagttc gtagctcgcg
    19801 gccttcgagt ccgggcgcag cggctcgatc accaggtcgg gggtacgcag ttcgggcacc
    19861 ggcatgttct gcagcacgag catggcctgg acctgcggag tgcccgccgt ggaccggcgc
    19921 tggacccgca gcagctccag ggcggactcg aaggggaact cctgatcgtc gaaggcctcc
    19981 gcgcaattgt tcctgacgcg cccgatcagc tcacgggccg tcggctcccc cgagacgtcg
    20041 gtgcgcagca gcagcgggtt gacgaagaag ccgatcagtc cggcgagttc gggccgggtc
    20101 cggccggccg tgggggacgc gacggtgatg tcctgctgtc ccgagtagcg cgagagcagc
    20161 acgtcgaacg cggccaggaa gaccatgaac gccgtggccc gctcctgcct ggccagcgcg
    20221 tccagccggg acaccagggg ggccggcacc gtgaacgtgt gggtgtcgcc cgcgaaggtg
    20281 ggttcggccg ggtacgggcg gtcggtgaac agccgcagtg gaggagcgcc gtccaggcgg
    20341 cgctgccagc gccgggtcag cccgctgagc ttctccccgc gcaggttctc gtgctgccac
    20401 atcgtgaagt ccgcgtactg gatctccagc ggcggcagcc cgggttcctc gccgcgcagg
    20461 tacgcgccgt agcaggccgt cagctcggcg acgaagaggg cggacgacac accgtcggtg
    20521 acgatgtggt gcatgaccag taccgcgacg tgctcctcgg gagccgtgcg cagcagccgc
    20581 atccgcacca gggggccccg gtacaggtcg aacggcttcg tcacctcggc ggtgacggct
    20641 gcctccaggt cgccgcgagc gacgtcggtc accgggacgt cgagctccgg ggcggggccg
    20701 atgatctgca ccggaccgtc ctcgtcgagg tcgaacacgg tgcgcagcgc ctcgtgccgg
    20761 tccacgacgg tgttgagggc gcgtcgcagt gcctcggtgt ccagccggcc gcgcagccgc
    20821 agtgccgcca gcacgtggta ggtcggacgg ccggggttga tctcgttctc cagccacatg
    20881 ctgcgctggg cgaaggaggc ggggaagacc agcacctcgt cgtcagtcac gggcggcacc
    20941 ctctccggtc gtcggggtgc gcccggagcc gctcggacgc ttcctgcgga acgccgacct
    21001 gtccctgggg cggatcgccg gtgtctcctc gggctccggg gcctgcgcct gctcgtcgat
    21061 gtaggcggag acctccgcga ccgtgggggt ctggaagagc tggccgaggg gaaggtcaag
    21121 ctcgaactcg ttccgcagtc tgtcgatgac cgcggctccc atcagcgagt ggccgcccag
    21181 ggcgaagaag tcgtcgtgga tgccggggtt gtcgacgccc aggacgtccg cccagatctt
    21241 caggacccgc tgctgggtgg tggtcaggtt cttcaccgcc tcgcggccct tggtccggac
    21301 ctcggacgtc tcgtacggcg gcgggaaggc cgtgacgtcc aggtggccgt cggtacgcag
    21361 cggccaggcg gtcacgggct cgacggtcgc cgggacggcg tgcagcggca gccggtcccg
    21421 caggtagccc cgcagcaggg ccggcatgga gcgcgcccac gcgccgaacg ccgggtcggg
    21481 ggctggcgcg gcggcggccg gctcggcacg ggtgtagccg cccgacagca gccgggacag
    21541 cggcacggcc gaaccgggct cggcgctctg cgcgcgcagg gcgaccgtca gctcgtcgag
    21601 gcgtgttccg ctcgggccgg cggccgcctc gtaaccggcg gcgtgcgcga cggccagcag
    21661 ggccacgggg tcgacgtccc gatcggcggg tacc
//
